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    <name>A0A1B9HS94_9TREE</name>
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        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
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    <gene>
        <name evidence="10" type="ORF">I206_07921</name>
        <name evidence="11" type="ORF">I206_106533</name>
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    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV700120">
        <property type="protein sequence ID" value="OCF46136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007355.1">
        <property type="nucleotide sequence ID" value="XM_019159605.1"/>
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    <dbReference type="STRING" id="1296096.A0A1B9HS94"/>
    <dbReference type="GeneID" id="30176290"/>
    <dbReference type="KEGG" id="kpin:30176290"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="297"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
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            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
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            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="334"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
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            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
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            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
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            <end position="168"/>
        </location>
    </feature>
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    </feature>
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            <end position="416"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022723"/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
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            <dbReference type="EMBL" id="OCF46136.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC72571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HS99</accession>
    <name>A0A1B9HS99_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-reducing end alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="4">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_07830</name>
        <name evidence="11" type="ORF">I206_100015</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Alpha-L-arabinofuranosidase involved in the degradation of arabinoxylan, a major component of plant hemicellulose. Acts only on small linear 1,5-alpha-linked L-arabinofuranosyl oligosaccharides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="4"/>
    <dbReference type="EMBL" id="KV700119">
        <property type="protein sequence ID" value="OCF46160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007379.1">
        <property type="nucleotide sequence ID" value="XM_019159515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HS99"/>
    <dbReference type="STRING" id="1296096.A0A1B9HS99"/>
    <dbReference type="GeneID" id="30176199"/>
    <dbReference type="KEGG" id="kpin:30176199"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="GH"/>
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        <property type="entry name" value="Glyco_hydro_b"/>
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    <dbReference type="PANTHER" id="PTHR43576:SF3">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43576">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE C-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ASD1_dom"/>
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    </dbReference>
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        <location>
            <begin position="354"/>
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        <source>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF46160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC66115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="569" mass="64446" checksum="1E8B67BE9CC3414A" modified="2016-11-02" version="1">MSVYSQHTTVLQAVLQQQSQVQFQSTPNHPSELRSTPLNLDIDRLVHPAEPPITDKLYSGFLEHLGRCIYGGIVDSPKTPSPAKLLVKQDKSGPLYKGRLGWRKDVMSCLSKDGELEIPMMRWPGGNFVSNYHWQDGIGPVSQRPKRIELAWLSDESNIFGTDEFIDYCRAIGSEPYICLNMGTGTLEEALSWLEYCNGTGDTHWAELRRKHTGRKEPHNVKYWGLGNEMWGPWQVGNLLPSEYARKARQWAHALKLVDPSICLVSCGETGASEWDREVIQALLPWADMHSIHFYTMLGHDKMSSVPGLDYEKNVFGAVAAEKHIEVCKSLIDMANIGRTIERMPARDMKICFDEWNVWDDVKAAGSNGLEQVYDYTDMLGFCAWLNVLVRKHKDIGIACLAQSVNVISPLMTRPDGILRQTLYYPLELFSKYMKHGHLLQLPSFPDVYTGPTYPVYIQQAGYNPSYIDSVAVSVKTPEGFSIRVSVLNRHPTADWVTNIAFSGFDLKSVRIHEIYHDDLIAKNTFEDPYNVKPVSTSLSKEGWETEYANGFTVKKHSWAFLIFDGTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HSP9</accession>
    <name>A0A1B9HSP9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_07776</name>
        <name evidence="5" type="ORF">I206_103823</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="KV700118">
        <property type="protein sequence ID" value="OCF46295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC69880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007514.1">
        <property type="nucleotide sequence ID" value="XM_019159462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HSP9"/>
    <dbReference type="GeneID" id="30176145"/>
    <dbReference type="KEGG" id="kpin:30176145"/>
    <dbReference type="OrthoDB" id="201213at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042237">
        <property type="entry name" value="PTRHD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46194">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE PTRHD1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46194:SF1">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE PTRHD1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF46295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC69880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="143" mass="16195" checksum="916929B76BE64769" modified="2016-11-02" version="1">MSSSISLTPTEVAPPKSTGLVMQIIIRRDLLTVHKWPIGPLLAQSAHASTAVLHKYKDHPDVQKYLEGEDGRGWEGMRKVVLEVQDENALRSVISKIDEMSNTIPYHLWIEQPENIPTALALIPNKRPKQLKKILDEHCKLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HT59</accession>
    <name>A0A1B9HT59_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chaperone regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_07690</name>
        <name evidence="4" type="ORF">I206_102320</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894017">
        <property type="protein sequence ID" value="OCF46455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007674.1">
        <property type="nucleotide sequence ID" value="XM_019159380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HT59"/>
    <dbReference type="STRING" id="1296096.A0A1B9HT59"/>
    <dbReference type="GeneID" id="30176059"/>
    <dbReference type="KEGG" id="kpin:30176059"/>
    <dbReference type="OrthoDB" id="342454at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46620">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN SPF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46620:SF1">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN SPF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="32"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF46455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC68394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="214" mass="24594" checksum="AA0EB2459C4693CE" modified="2016-11-02" version="1">MASNLDSVLKKNANDLAKELEVDRILKAFKLNPYDILDLPITATEAEIKKQYRKKSLLIHPDKFKHEKGLEAFDYLKKAEDHLSDPVKRKDIDMIMTHARTQVLKSILGSGYSTNVSDDDARLSNLTPPLEQQVRAKGREILVEDELARRRKTKLAYANEGAEKAKQEADVAARKRKVEDQAKWEERREERISDWRSFSNKKAKKGKKSNHVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HTH1</accession>
    <name>A0A1B9HTH1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Monosaccharide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_07412</name>
        <name evidence="13" type="ORF">I206_106699</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894016">
        <property type="protein sequence ID" value="OCF46559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007778.1">
        <property type="nucleotide sequence ID" value="XM_019159106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HTH1"/>
    <dbReference type="GeneID" id="30175781"/>
    <dbReference type="KEGG" id="kpin:30175781"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000061">
        <property type="entry name" value="MFS sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF55">
        <property type="entry name" value="SUGAR TRANSPORTER STL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="462"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="34"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="534"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="563"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCF46559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC72735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="581" mass="62857" checksum="E11988BD982CE60A" modified="2016-11-02" version="1">MSTPPMEKPNAVLGGTQPLVKYGGLNGNALLYAVVGIATCGFSLFGYDQGLMSGIIASRQFNTEFPATKQHDVNDVHAGTVQGSVTSCYEVGCFFGALIAFFIGDKMGRRKMMFGGAVVMIIGTIISVTSFGPGDTSGRGNVGGFVQFIVGRVITGFGNGANTATIPSWVAETSKAHNRGFLICMEASTVAVGTVIAYWIDFGLSFVDSSVSWRFPIAMQILFAMILIGGVAVLPESPRWLIAHGRPDEGLRVIAALDARSIDDPVSVADHKKIVDALQAQMAAKSNKTRDLLKMGKQQHFRRALVGASTQLFQQIGGCNAVIYYSTVLFENQIGLETQLSLILGGVLSIVYMIFALTSFFLVEKVGRRKLFLWGTVGQAVSMFITFGCLLPGRATSAKGAAFGLYFFIAWFGATWLPLPWLYPAELNSMAVRTQANAVSTMVNWIFNFTVVQVLPTMTASIGAYTFLFFGCINLVFLPFIYFFYPETTGRSLEELDVIFAHAHLTQRRPTLVAAELPKLSDHQIQEMTDRYDIHGGDQAEDPEAYGAAVNQGAPDTTLPPVHPHDHANDGDATRVPTPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HTI8</accession>
    <name>A0A1B9HTI8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_07438</name>
        <name evidence="3" type="ORF">I206_106672</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
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    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the ATG13 family. Fungi subfamily.</text>
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            <dbReference type="Pfam" id="PF10033"/>
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    </evidence>
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            <dbReference type="EMBL" id="WWC72473.1"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000094020"/>
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    <sequence length="1150" mass="121173" checksum="CB5107AFFEC323C4" modified="2016-11-02" version="1">MSYSPSPLKPYLQHTVSSSSRTPNPNTLVAQQSGERNLASSSASSSQIGTGQVSRADQVLYRFYLKTVGVLVDGRLTHYAGKQAGEKKYDKWFNLILPELDVHKADLGIYRSISSYQPYTEAGSTLSPESCTIPPLLIAFILDTKDIPNGQALLWHKDGAKIPIDIGLAGKGKGKEKENRSGIILERWTFTAQLPSPDAPSTSQLAPHTAYRLGIIHFRALFSLIRLLPAYRLFRRLRRSNNGLRMGLKLWGAEGYPNSVEGLEEAWEVMERGLVGLDTGLDQLSAKDTARPEEIERYEFPKLDLFGNEYTLTTDFRPEVDFSVEDMEAVLSEKFVDMDEDWFTPTVSRRNTQDNSPTIKPETSRKSSMPTPIQSNASPIPQRQAALPAGSYSSSNRPAASRVVSSQEKRPATSQWGALAEGLPFAGSSSTSQRDMTGHEPPSPSMATPAAIVAARRLSGHSIQPFASASPSTSLLRSTPPQAYVGSPVPTSSSARPVMGGSRPSSIGRTSSFLSQSGRSFTHAQLANMYAGSASPPVTGAMSGVSVQIPTSSPPPGQSPISPSSLSFTKQPVPRSISGRPYYMTPSASSPFIPESLERESSLSSHTGPPGIIKRYSSSLSQRSGRAISGSGGATGTAVGSQGSSVGEGTSPGQGLLRRTSTRESGLRHSLEGPSASVIASARLPPPDEDDIQAFLKTLDALPQPPSLAAQAIQASRSYLPSTSSSLSAPSIPLTPSPLLTSSGSPGNSGGAAYGGRVPMTKQHIDEELRRMAGSFSLNTPPTFTGGATSGSAIDSGVSSPARASSGSHPSSIGLLSASRPSSATRRPIPSNLSEYDASGNSRPMYRRQTSGEKSPLGPGSASASSNGLAYKAISPATAKPMTSLKSADEITKHAHPTSSSAVTGAARSLPGRGVSRDVVVHDEEPMPIRSVGGVLSPQTTGETSTITSRNTDSARSRRGPVLLRGGFGDPSCRPSTSRSSPSHSPVRDVTLGKGVGLGIKESSSPSGRMIDEVEQQIGNNYRSPYATRRLSAVSNFTSNSIGTTGGSANLSSTNGQGISGYPGLSTTNSNSNRAIRAQRTAPSSLGRNNDEIIHASVGQVGGAIGGRRHRVGSESGITRLSEEDIRSATDEQLDELEEKLTGMGLSRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HUC9</accession>
    <name>A0A1B9HUC9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein MON2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_07262</name>
        <name evidence="9" type="ORF">I206_106458</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MON2 family.</text>
    </comment>
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        <property type="protein sequence ID" value="OCF46875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="WWC72496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_019158956.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032629">
        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032817">
        <property type="entry name" value="Mon2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF333">
        <property type="entry name" value="PROTEIN MON2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16206">
        <property type="entry name" value="Mon2_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Mon2/Sec7/BIG1-like dimerisation and cyclophilin-binding" evidence="7">
        <location>
            <begin position="5"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2/Sec7/BIG1-like HUS" evidence="5">
        <location>
            <begin position="194"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2 C-terminal" evidence="6">
        <location>
            <begin position="968"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2 C-terminal" evidence="6">
        <location>
            <begin position="1024"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2 C-terminal" evidence="6">
        <location>
            <begin position="1505"/>
            <end position="1555"/>
        </location>
    </feature>
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        <location>
            <begin position="650"/>
            <end position="680"/>
        </location>
    </feature>
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        </location>
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        <location>
            <begin position="1633"/>
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    </feature>
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        <location>
            <begin position="921"/>
            <end position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF46875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC72496.1"/>
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    </evidence>
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            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
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                <person name="Hansen M."/>
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                <person name="Imamovic A."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
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                <person name="Birren B."/>
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    <reference evidence="2" key="4">
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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    </evidence>
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        <source>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="2" key="3">
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="Zeng Q."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
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            <begin position="1257"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1273"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1296"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1343"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1386"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1408"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1454"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1474"/>
            <end position="1487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF46922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC72542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1487" mass="152665" checksum="9E49D4DC7BFE212A" modified="2016-11-02" version="1">MSGQNPRSSLQGAARQNAHPRLHALSKPYSRPSSFSGLSSSATMTDLANVSSSLGSPSKSPTKSSTTRPGLSGDSRSSSFSSLPRSGSDSSLFSGIKSIFSRPLQWLATPTRDQITTANKRDSFSSFGHDLEDPDSPSETRNQKRIRRSSPSPEKQKSKSNGVSKGHYEPEPEFQVQGRAVSGFMLPPLSPNVTLKPKSHLPQHMTTQNPTNFSRPLGSSSGLSSSKSMSYLDPPSDVLGSSSPRKGGMLTRSKRVELSSLVDDDDRSMDGLEKGKGKEEEKTWSPWKSRYSTAGGAASSAANVRPTTPSRKTPNRLDSRDFALPSLSPFKPPPSPLHRQSPHPPNLGGSTSGLTRSATTANIRRAASVASDVSMSGGLTRSGSVKGLRQSGSMLFGSVNGDREGGRDDDRMSVDGEQRQREGSVLDWFMKDRWDGRATSPASVAASRRLGSAGPSSSHPPIRKGQLVWHEEEKAFVRESDLRLSQAPPAVHKSEAERILHTLESMRKTPLTDARKGDVPPLIGQSSRTMRKTINVPLATAAAGDSAKQRRDKDRLGGDDRVSVMISPYGRRKVADQQVRDDRRSKMAEDRDYRPSPTPTASDARSRSHSRTSDVEMDRPSSSQKSLSPAPAPTPRRSSRLKKPSAAEEIPTPKANRRTKRGASKQPETMYEEEHTQRTPKGRKSRKQTVDRGTSPDPAPPVPTITATAPSPGGPANADSSTQTVSNSNYQPLADGERSRGGSSLRARSDVSKRTHVGAASYSRSVTPSSGRFSAREEDLPDMDELEQAKIPLPSFSGISFAGLNANPPASNGDAAQNASQSSAPAAAQPSSSLGVPSQRKPAGPLARVGLSSTRPRASSPLAGGSIVAQPESPPTAAPPARSTEPAQPPANGFFTLNGSTPTVPSSTTGSTTALSKPAASSFFSGPSTNGDTNKEKTFSFGLGQPPANPAAAEPEKSSSGGIPDFFGKKSVPPSGTTTPTSIPAFDFGLPKKSTDEPKAPPAELPSSTFSFGKPAEAPKATASGTSSTGGFSFGAPASKQPEKTAAAVPSFSFGSFKPAEPAKSTFNFGASSASSSKPAESARPTFSFGTPSSTAAAEKPAEATKPAFSFGTSSIAPAKTAEPAKPAFSFGNTSASAPAAKVAEPAKPAFSFGTPTSNATTSAPASSGFSFGKPAEKKDTAASNPFGPGASSAATSTPSFNFGASSGTKTFAPFGSSQPNGDVSKSNPFGASPITTPAAASASSGFNFGASAPSAQPNGASSGFGSTAPAAQASNPFGSANTSPALGSAPNPFGQTQPSSPALASAAAPSFSFGQSSSTPTTGFGSSAPAATTGVSNPFGQTSSTTPAATPASAGFNFSFGAGSTSNPAPAPNASGFGGFGQQANTTPSTPNTNSSFAFGAAPQPSTPTTSQSFAFGASTTPSIAPSSGFSFGAPTNNAQQQAPRFGSPAPADGGGFSLGANDGGAPGSPGGRKVKGLPRRGAVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HUK9</accession>
    <name>A0A1B9HUK9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptide hydrolase</fullName>
            <ecNumber evidence="9">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_06729</name>
        <name evidence="12" type="ORF">I206_102177</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M28 family. M28E subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="9"/>
    <dbReference type="EMBL" id="KV700117">
        <property type="protein sequence ID" value="OCF46955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC68254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008174.1">
        <property type="nucleotide sequence ID" value="XM_019158428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HUK9"/>
    <dbReference type="STRING" id="1296096.A0A1B9HUK9"/>
    <dbReference type="GeneID" id="30175098"/>
    <dbReference type="KEGG" id="kpin:30175098"/>
    <dbReference type="OrthoDB" id="2214at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF56">
        <property type="entry name" value="AMINOPEPTIDASE YDR415C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008448403" description="Peptide hydrolase" evidence="9">
        <location>
            <begin position="31"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="10">
        <location>
            <begin position="212"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCF46955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC68254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="451" mass="49761" checksum="677E5C6C6FAF5999" modified="2016-11-02" version="1">MVKINAIGALLALPALSLVISSPLIESVNSDQLPLNNLLSTSASAQHEVHPSILSALDKYDDPVEALLALKPELEGMMAERRLIRVFGEDANEGIWMTEGDKLRLRRAGKRFMDLTESQDLSESNLMAGKANTPDIVHQRYIKPIFADLKTSHMHDVLVKATSFFNRYYYAETGVQSARWLHDHIASIIAQSPTGEFISLEYHTHRFPQPSIVARFEPPTRNASLPLTIIGAHQDSANYLFPLLPAPGADDDMSGSTSILEAFRALALRGYIPARGPVEFHWYAAEEAGLLGSQEIVAYKRGLNANVGAMIEFDMTAFVARNTTPHVFLLENDADDNLTKWVVKLAREYVDIPVNTSSLEAGAGSDYMSWTRGGYPAAFAAEGDPLAGGFPGQFDGYIHTDKDRMDVDDETGFFSLEHMLEFSKLAVAFAVEQAGWSDKHTRSGDNKKSVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HUM0</accession>
    <name>A0A1B9HUM0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Charged multivesicular body protein 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_06740</name>
        <name evidence="3" type="ORF">I206_102165</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700117">
        <property type="protein sequence ID" value="OCF46966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC68242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008185.1">
        <property type="nucleotide sequence ID" value="XM_019158439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HUM0"/>
    <dbReference type="STRING" id="1296096.A0A1B9HUM0"/>
    <dbReference type="GeneID" id="30175109"/>
    <dbReference type="KEGG" id="kpin:30175109"/>
    <dbReference type="OrthoDB" id="10250120at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF96">
        <property type="entry name" value="BCDNA.GH08385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF46966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC68242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="541" mass="61007" checksum="974E09019CFB2804" modified="2016-11-02" version="1">MSSSDLPPFLRTIPPPTAPPSIARLQALYASTSSQRTTNPTGYKANYQWWSSVIEETLRTGWLNGEEGDRLILKVDDSMLSKLEDNLGRRPKGIGGVIDGMINTTPPTLYLLSTYLSSLTPLHAPPSLTSRFIGKPLWWAVSQLNPFGSSSETIEKEDVLWSRYGKGKEYVHIPLLEQSASAFIAHLSKNPILSYTDALFDMDTFSEGYGEICLPSSSSSKKLPAGIHKLSNKDIEVLIKWLNRDCGLIVSDGKIIKILEADQIPTDHPITEADKGVISVINAQRKVEKQIIGIEEQINQSQEKAKKQLAKGQKTTALSYLRSKKQLEDLLAKRISSSEQLGTVIRSIDQAKGDVEIMSAYETSTITLKSILSNPSLSIEKIENTTNLLAEVIADQEEIDQAIKIGGELSMNEKRIEIDEEELVSELAELVKEEKVLQDKVKEQEKAEPDKRKKEKQDLIEQIKRKEEKEREKQETEEMKNQAKVNNLSSLTSQNTGELNKFNDDEEWERRYQDAQIRKEAEIQRSLDERLRKEEKRIAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HUZ7</accession>
    <name>A0A1B9HUZ7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BolA protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_06867</name>
        <name evidence="3" type="ORF">I206_102040</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BolA/IbaG family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700117">
        <property type="protein sequence ID" value="OCF47091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC68119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008310.1">
        <property type="nucleotide sequence ID" value="XM_019158564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HUZ7"/>
    <dbReference type="STRING" id="1296096.A0A1B9HUZ7"/>
    <dbReference type="GeneID" id="30175236"/>
    <dbReference type="KEGG" id="kpin:30175236"/>
    <dbReference type="OrthoDB" id="411584at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044572">
        <property type="term" value="P:[4Fe-4S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.90">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46230:SF7">
        <property type="entry name" value="BOLA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003113">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF47091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC68119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="13161" checksum="5E96AEED1DCCB35C" modified="2016-11-02" version="1">MSSNSEIGRQATRIPGPVETSIQQKIIESFQPILLRIYNDSSKHSHHSAMRASGGGNGETHFAIHLVSPEFKGKTSIARHRMINALLKDEFDNKGLHALSLRLKTPEEWEKEGGGEMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HV06</accession>
    <name>A0A1B9HV06_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PAN2-PAN3 deadenylation complex subunit PAN3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">PAB1P-dependent poly(A)-specific ribonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Poly(A)-nuclease deadenylation complex subunit 3</fullName>
            <shortName evidence="7">PAN deadenylation complex subunit 3</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PAN3</name>
        <name evidence="12" type="ORF">I206_06869</name>
        <name evidence="13" type="ORF">I206_102038</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer. Forms a heterotrimer with a catalytic subunit PAN2 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts (via PAM-2 motif) with poly(A)-binding protein PAB1 (via PABC domain), conferring substrate specificity of the enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The N-terminal zinc finger binds to poly(A) RNA.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for PAN2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. PAN3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KV700117">
        <property type="protein sequence ID" value="OCF47093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC68117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008312.1">
        <property type="nucleotide sequence ID" value="XM_019158566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HV06"/>
    <dbReference type="STRING" id="1296096.A0A1B9HV06"/>
    <dbReference type="GeneID" id="30175238"/>
    <dbReference type="KEGG" id="kpin:30175238"/>
    <dbReference type="OrthoDB" id="204958at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3700:FF:000001">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex subunit PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.5160:FF:000002">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex subunit PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03181">
        <property type="entry name" value="PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030844">
        <property type="entry name" value="PAN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041332">
        <property type="entry name" value="Pan3_CK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272">
        <property type="entry name" value="DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272:SF11">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18101">
        <property type="entry name" value="Pan3_CK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25586">
        <property type="entry name" value="zf-CCCH_PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="35"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="274"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="8">
        <location>
            <begin position="35"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Knob domain" evidence="7">
        <location>
            <begin position="564"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="525"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="359"/>
            <end position="366"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="426"/>
            <end position="427"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCF47093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC68117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="663" mass="73227" checksum="30BB6B29BC9F6120" modified="2016-11-02" version="1">MAGQGVKSAAIQIRAPTSNESKGRDSPIPTEKKRETPQRICRNVMIYGYCKFQDSGCVYYHPPPGADLNAASTPLTGSPIATIPTLLPKDTSTKPSFGLGAEHLSAPVFVPKTPIGETSSPRATTPSLIPANVTHSPLTPTATAPSTAGMTPSWPALGNQGGLLSRQDNSMSFDDSLISMDPSQSSAMDGSMFMHQAIRQPLDQHLYVSPLPHLSNPPVNHHPLHSFFIPDDLRRTLQARNEAIYQGTQSGSSNGLPNELGIYHSLKLIQSLNQPHPQNQSQNAPSKVYVHPAPVYKAVSSVDGNVYCLRRIEGYKLVNESAFGAIDTWRRMRHPNIVGLREAFTTKAFNDNSLILVYDYHPLSTTIWDEHLIPNPAVAQNNNSPGRGRTGLPIQERVLWSYITQIANALKAVHSSGLAARNLDPSKILVTGKNRIRLNGCGVWDVLAYDPSTHVGHYQQEDLVSFGKLIISLCCDFFQPGQHPALPLEHIQRNYSPDVKSLVMFLISKPSPMKSVDEAIKIMGPRILNELDAMQNYADTLESDLGAEMENGRIIRLLTKLGFINERAEFELDPRWSDTGDRYILKLFRDYVFHSVGVDGKPILDLSHVLTCLNKLDAGLDERIMLVSRDDQSCLVVSYREIKHCIEAAFNELRNAGNPMRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HVE0</accession>
    <name>A0A1B9HVE0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">KH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_07007</name>
        <name evidence="6" type="ORF">I206_101903</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700117">
        <property type="protein sequence ID" value="OCF47229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008448.1">
        <property type="nucleotide sequence ID" value="XM_019158702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HVE0"/>
    <dbReference type="GeneID" id="30175376"/>
    <dbReference type="KEGG" id="kpin:30175376"/>
    <dbReference type="OrthoDB" id="397265at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22385">
        <property type="entry name" value="KH-I_KHDC4_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22386">
        <property type="entry name" value="KH-I_KHDC4_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000037">
        <property type="entry name" value="KH domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047890">
        <property type="entry name" value="KHDC4_KH-I_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047889">
        <property type="entry name" value="KHDC4_KH-I_second"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056149">
        <property type="entry name" value="PRP5/DDX46/KHDC4_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031121">
        <property type="entry name" value="RIK/BLOM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15744">
        <property type="entry name" value="BLOM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15744:SF0">
        <property type="entry name" value="KH HOMOLOGY DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23469">
        <property type="entry name" value="KH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="ATP-dependent RNA helicase PRP5/DDX46/KHDC4 KH" evidence="4">
        <location>
            <begin position="63"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="KHDC4/BBP-like KH-domain type I" evidence="3">
        <location>
            <begin position="186"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF47229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC67984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="389" mass="41558" checksum="FD7A11A037508E2C" modified="2016-11-02" version="1">MSEDRKSRWDDPSSSTPPNAAADASDAAARAAAIAAKIAASLRPGAQGNELVKQEKKDEGDFVKDIEVNDLRNRYVLTKGSTQKQIEEETGASVVTKGVWVPDRTKMPVGESPLYLHIVATSQSILDAAVSKVQELIDQELGPLLDQRTIVARNRALGLPPPENAPTGGRQKWPEEKLYISLESLRNFNVRAKTVGPGGMFVKYIQAETGARVQIKGQGSGFMENDTGRESDDPMHINIAAPTQDQIDRAKVLCNDLLEVLRQEWSKARDAMAAQQQQHHGQGGVYQQGYGSYAAPQGQQGGQDAYAAYYAQQNGQNGTPTSAPSATPAAGGAAGGATPAEGTDAWAQYAAYWAAYGYDVNDPQFQAWQASQYGQQGQAPQAGAATPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HVR9</accession>
    <name>A0A1B9HVR9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">allantoinase</fullName>
            <ecNumber evidence="5">3.5.2.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_06255</name>
        <name evidence="12" type="ORF">I206_101773</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nitrogen metabolism; (S)-allantoin degradation; allantoate from (S)-allantoin: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.5" evidence="5"/>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008578.1">
        <property type="nucleotide sequence ID" value="XM_019157965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HVR9"/>
    <dbReference type="STRING" id="1296096.A0A1B9HVR9"/>
    <dbReference type="GeneID" id="30174624"/>
    <dbReference type="KEGG" id="kpin:30174624"/>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="UniPathway" id="UPA00395">
        <property type="reaction ID" value="UER00653"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004038">
        <property type="term" value="F:allantoinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017593">
        <property type="entry name" value="Allantoinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050138">
        <property type="entry name" value="DHOase/Allantoinase_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03178">
        <property type="entry name" value="allantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668:SF2">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01137">
        <property type="entry name" value="TATD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="10">
        <location>
            <begin position="60"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCF47359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC67856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="483" mass="53664" checksum="8B337053E73AEDAE" modified="2016-11-02" version="1">MVKRQIILAPQALLPSKDDPQAATIEIDLSLGTIISIKEGIIPPLQEEDVEIIKIEDDKIVLPGLIDTHVHLNQPGRTEWEGFQTGTLAAISGGVTTLIDMPLNSIPPTTTLKGLEIKRKEALKIGINSDLGFWGGIIPGNQGELVNMLNNGVKGFKCFLIDSGVEEFPHVEEEDLIKACEALKGTNALILFHAELDDSNPCIPTSTKNENSHSHSHNHSSSSSSQSSYSKFLESRPEEFELKALKLIIKFTKLYPELNFHIVHLSSSNAIPLIKKAKFSENIKNLTIETCFHYLCLSSELILNDDFKTEFKCCPPIRSELNRKRLIENLLEDSSKNEKNENIINYIVSDHSPCIPELKKGNFLESWGGISSLGLGLSLLFNEIGNKIKLGKLINFLSINQAKQVNLKNKGELKIGNQADFIIFNPNVKWTVTTESLLFKNKISPYIGKTLKGRVEKTYLAGQLVWDYEKGIDGAVLSQGRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HVU1</accession>
    <name>A0A1B9HVU1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="7 11">3.13.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I206_06293</name>
        <name evidence="15" type="ORF">I206_101738</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
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        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.</text>
    </comment>
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        <reaction evidence="8 11">
            <text>S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine</text>
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            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
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        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="10 11">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10 11" id="KW-0520">NAD</keyword>
    <keyword evidence="4 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S-adenosyl-L-homocysteine hydrolase NAD binding" evidence="13">
        <location>
            <begin position="190"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="156"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
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    <feature type="binding site" evidence="10">
        <location>
            <begin position="221"/>
            <end position="226"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
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    <feature type="binding site" evidence="10">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
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    <feature type="binding site" evidence="10">
        <location>
            <begin position="298"/>
            <end position="300"/>
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        <ligand>
            <name>NAD(+)</name>
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            <position position="345"/>
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            <position position="352"/>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HVY4</accession>
    <name>A0A1B9HVY4_9TREE</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">I206_06321</name>
        <name evidence="3" type="ORF">I206_101712</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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        <property type="component" value="Chromosome 2"/>
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        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
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        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF4">
        <property type="entry name" value="ACID DEHALOGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF47421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC67799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="245" mass="27191" checksum="FA6A89DD59102935" modified="2016-11-02" version="1">MPSVVFDVVGTCFSYDNGAEAVQHRLGHKLAKYGIPSKLLFYAWVCGTERDYSYLSQIKQYKPFFDILSGTLKRVLFQAGVPAEDLEDFFTTEDVEYIREEYKKLKPRPGLSEMMQTLRDGGFEVWCCSDANVDRVKGYFDKAGVPMPLDHILSADMVKAGKPEPAVYKFAREKAGSDQPGEVSIFAASHAWDIAAAKSAGFSTAYTTTYELDECVDIFGKADLVTPDLVTLGKGIVDKWGKKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HW30</accession>
    <name>A0A1B9HW30_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">REJ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_06374</name>
        <name evidence="8" type="ORF">I206_101656</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008692.1">
        <property type="nucleotide sequence ID" value="XM_019158079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HW30"/>
    <dbReference type="STRING" id="1296096.A0A1B9HW30"/>
    <dbReference type="GeneID" id="30174743"/>
    <dbReference type="KEGG" id="kpin:30174743"/>
    <dbReference type="OrthoDB" id="3250803at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF26">
        <property type="entry name" value="AXIAL BUDDING PATTERN PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="366"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="38"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="374"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCF47473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC67744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="457" mass="47018" checksum="B493E3FD236752B3" modified="2016-11-02" version="1">MSSQLTDPITDVTSQSPTTVQTSLPITESSAAASVVDTTPSAQPSAEPSASASPTQSPSLSPSAEPSAQSSQAESSASPSPSAVQSSAAQSQSASPSASATPSASASPSTSEEQSASASPSVTQSQSQSASPSASASDSQVEQSSTVAPSTTTSVVQPSLVSQSSSSSEIPITDSEGHTTAKDLTTTIATSTDGSGKVYTITKVVAKPTGSLSSSGSSSGNSGFFSNSGAVAGTFVAVGLLVTAGIIAFAIFMLRRRRRQRLDRDVAAAAAAAAVAAHHSSRSAFDDDEEQPSMTQYGGYYASTTPGIDIHGQPQTDVGGYHDYEDPSGGYDPYAINMTNLNSGDRMSTATVPGMAGFGATSAQNVYDQHHQQQEQYSNDQYHNQQQPDYTQSLPQSQDNTTNGYYFDPKQAYEYQEEEDAYGGYDQQHSGVRPLRPGSAGSVNPNDSRGGLRVANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HWA7</accession>
    <name>A0A1B9HWA7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">[histone H3]-trimethyl-L-lysine(4) demethylase</fullName>
            <ecNumber evidence="4">1.14.11.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">I206_06429</name>
        <name evidence="20" type="ORF">I206_101601</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="20" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 2-oxoglutarate + 3 O2 = L-lysyl(4)-[histone H3] + 3 formaldehyde + 3 succinate + 3 CO2</text>
            <dbReference type="Rhea" id="RHEA:60208"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="1.14.11.67"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the JARID1 histone demethylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.67" evidence="4"/>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008747.1">
        <property type="nucleotide sequence ID" value="XM_019158134.1"/>
    </dbReference>
    <dbReference type="STRING" id="1296096.A0A1B9HWA7"/>
    <dbReference type="GeneID" id="30174798"/>
    <dbReference type="KEGG" id="kpin:30174798"/>
    <dbReference type="OrthoDB" id="1678912at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0034647">
        <property type="term" value="F:histone H3K4me/H3K4me2/H3K4me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="CDD" id="cd16100">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Cupin"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
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    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
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    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
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        <property type="entry name" value="KDM5_C-hel"/>
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        <property type="entry name" value="Lys_sp_deMease-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
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    <dbReference type="InterPro" id="IPR004198">
        <property type="entry name" value="Znf_C5HC2"/>
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    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
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    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
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    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF33">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE 5"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF01388">
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    <dbReference type="Pfam" id="PF08429">
        <property type="entry name" value="PLU-1"/>
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    <dbReference type="Pfam" id="PF02928">
        <property type="entry name" value="zf-C5HC2"/>
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    </dbReference>
    <dbReference type="SMART" id="SM01014">
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    <dbReference type="SMART" id="SM00501">
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    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
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    <dbReference type="SMART" id="SM00545">
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        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="ZF_PHD_1"/>
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        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjN" evidence="17">
        <location>
            <begin position="179"/>
            <end position="220"/>
        </location>
    </feature>
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            <begin position="244"/>
            <end position="333"/>
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            <begin position="481"/>
            <end position="532"/>
        </location>
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            <begin position="653"/>
            <end position="819"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="14">
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    <feature type="region of interest" description="Disordered" evidence="14">
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            <begin position="1628"/>
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            <begin position="1808"/>
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    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1950"/>
            <end position="1979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
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            <begin position="7"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
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            <begin position="46"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
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            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
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    <evidence type="ECO:0000259" key="17">
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            <dbReference type="PROSITE" id="PS51183"/>
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    <evidence type="ECO:0000259" key="18">
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            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OCF47528.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="WWC67689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1979" mass="220716" checksum="1BD1044FCEC5E81B" modified="2016-11-02" version="1">MALQQEGAVSTPTSGASSYPSRTRMGSLSGKSKTPRGTPTKNEGTSRPSIKPSPSDSSRRRPTFTTSLNYPEVLPAPTYFANEGELQRGQRRSKVEALTKLDRAGTPIQINNGPTGTSFLPSSAQSSTPQPVAGPSASRNPLHRPVIVNPPFNPASVRQSAPRYPPARTTPRLFGIDECPTYYPNEEQFKDCMGYIESIADDARPYGICKIVPPEGWKMPFTLDAETFRFRTRLQRLNQLEAASRAKINFLDQLSMFHNQSSENEITIPKIDRQPLDLWKLRKEVNKSGGYLELDRTKSWPKLTETLGHKASWSGQVRSAYIDIILPFDNYSVRAKSASVSPLTPLNNSSINGNGTVKPPAFASDAPSSPSQTKSAGRMGAIKHSPRTRFSSRMSGAGFGGSGGETQSLPTLTASLPTINGLEAAAEIERPSSATPSLTTLKIKVPGFSTRDGSESELSDADSSSDGSPKGKVGTPEYKKGDICEICRFGHAAEKILLCDGCDRGFHTYCLDPPLASVPANEEWFCTSCLLSQGDDFGFGEGEDHSVASFQARDASFSWHWWNRHRPNPAASSSQSPPRKHDQNGFAQMPSQPLNQLERKFGKVTVTEDDIEREFWRLTESLTDTVDVEYGADVHSTTHGSAGPTMETHPLEPYATDGWNLNNMPILPDSLLRYIRSDISGMTVPWIYLGMMFSTFCWHNEDHYTYSVNYMYWGETKTWYGVPGSDAEKFEQAMKSEAPELFEQQPGLLFQLVTMMNPGRVKEAGVKVVACDQRPNEFVITFPKAYHCGFNHGINMNEAVNFALPDWLPDGREAVMRYQQHAKPPVFSHNELLITITLYSETIRTALWLKDNLTVMVEAESRRREKLRIANPALTEILFEEDGAEDQYHCTKLVACLDHADQLCACAKSKKALRKRYTEAQLEEILAIVVARAAQPDAWRARLYALLEVPRPALKSLRALVADGEKIAYPIPEVFTLRALVDRANSWVERVSSLVTRKAAGRRRKGKKEEDEDEDMVIDRSPETLSTLLSEAEKLAFDAPEILQLRQLLMNIQGFQSEASLILSTPESELELEKCKTALILGESLNLDLPEVTAIMNIVNRLKWFRKVEDEVDDRTLEYDDTVNLLEQAEEYEIPEDHPTISELKMRRQRGAEWLNAVDTLLSSPRIKIEEISDLIEGKDFVPVSTDKMRQLESIRKTVLNWQASAKNLLSTSGSALAASRLCKNVSSATPPISRVEIPEMVELQAELNHHAQWQSQICRILEIPVAKIGSTMNYLKREFESHLNPEDDEPNEEFVCFCRGSPGNVMIKCQNCQGEYHPKCVGVSPKYIDQLYQCEMCQRLLPGLSPSLNDFGVIVVSQRWRFKITPPEFKVAQEIVEMALRYSSTVLKIIDPKDTAEPCMDISKIQHSIRKIYNLPLLLDATNVETKERVVFISWLFRRLQNAIKVHNGISTATANGGEKPKSKGTRGRKAKLIIAQSYPKEFRCICQFPDISALNRTPYRPDPEDNDESRRLTVECARCSQKYHNECVRAGPELSRPLLPSADSAEGLPERRSFWRCPCCAVKEAKYYMKGVEVRVQMRDQIGTDQYIDYRSTINDYAEKPIIITLQPSTDAIILECTNFIPPILPEDYTREGSGNEEDGQSIKKRRKLRPSEINSTSDMKLNGNGGGQSSPVSTNAIPPQHHYQNLQNGHTPHTAITAPVNSKVPSVHPIYPSTATAISRGPINGYTGPQTAYPSPITHHIHQPQTARLSDPVPVNYRTAADDLMLNGQAHSSSYPHHPISRSPEMSIPVMNSVVELPARTLESLPSLDRPKSPNKLVSPTQPPPQILSSNDEVTSAYDRKSGSPHALPTDVPPKESQNSPSHRAEENGSGPPIPVFEVQHPVEEQEPELENHLKTSERLQPIISQEIPPVLPIESMEEIPRMDINKSPSPSKRKLSDLGEKIDLSENVPIVNMERQRSSSTQGSSVHDAIVIDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HWN5</accession>
    <name>A0A1B9HWN5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">5'-deoxynucleotidase</fullName>
            <ecNumber evidence="7">3.1.3.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_06592</name>
        <name evidence="13" type="ORF">I206_101437</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.1.3.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the HDDC2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.89" evidence="7"/>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008905.1">
        <property type="nucleotide sequence ID" value="XM_019158292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HWN5"/>
    <dbReference type="STRING" id="1296096.A0A1B9HWN5"/>
    <dbReference type="GeneID" id="30174961"/>
    <dbReference type="KEGG" id="kpin:30174961"/>
    <dbReference type="OrthoDB" id="10254258at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002953">
        <property type="term" value="F:5'-deoxynucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3210.10:FF:000043">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.2, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039356">
        <property type="entry name" value="YfbR/HDDC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845:SF13">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13023">
        <property type="entry name" value="HD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="11">
        <location>
            <begin position="81"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="244"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCF47686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC67529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="269" mass="30056" checksum="E08C96E3BED45DA0" modified="2016-11-02" version="1">MPIAIPAVSSHQVNKMNVLPVDQVHGQVEETSKVLGAGGKELPAPYKSSGNEALDTLAFLHLLEQLKVQKRSGWIREGVKEAESISDHMCRMALMAMMIPQDPAKPLDIPRCVMMALVHDLAEAHVGDITPVEGVPPHVKHQLEEQAMDSFLNEMLGGAGNKDARERFRSLWDEYEARETPESKLVKDLDRVELALQAVEYERSQDIQSLSPFFIGSIPHLENPTIQKWAETLMEERRQLWASRGREKEEQDGLQGVTVGSKVKKPNGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HWT6</accession>
    <name>A0A1B9HWT6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Adenosine kinase</fullName>
            <shortName evidence="11">AK</shortName>
            <ecNumber evidence="4 11">2.7.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Adenosine 5'-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I206_06625</name>
        <name evidence="14" type="ORF">I206_101405</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine + ATP = AMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20824"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.20" evidence="4 11"/>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008938.1">
        <property type="nucleotide sequence ID" value="XM_019158325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HWT6"/>
    <dbReference type="STRING" id="1296096.A0A1B9HWT6"/>
    <dbReference type="GeneID" id="30174994"/>
    <dbReference type="KEGG" id="kpin:30174994"/>
    <dbReference type="OrthoDB" id="432447at2759"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004001">
        <property type="term" value="F:adenosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01168">
        <property type="entry name" value="adenosine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001805">
        <property type="entry name" value="Adenokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769:SF3">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00989">
        <property type="entry name" value="ADENOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 11" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="12">
        <location>
            <begin position="25"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCF47719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WWC67497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="355" mass="37172" checksum="CC3A3D75F4AD2F0D" modified="2016-11-02" version="1">MAPIVVSLGNPLLDIQVAPNEGPAYLEKYGLKSNDAILAEEKHMPIYDDIVANAKVQYVAGGAAQNAARAAAYVLPQGSVAYIGSVGEDDLKQTLLSANEAEGVQSAYQTQAAPARTGACAVILSNHDRSLCTTLRAAEMFTPSHLSTPEISQLLDGAKYFYIEGFFLTHGLESALEVAKQASSKGKTVVLNLSAPFIPQFFKVQLEELLPHVDILIGNESEAEAYREAAGMGSATLAQVATSLAASSKSNASRPRLVVITQGADSTLVASSNASGIAANLSPEDENPKTFPVPKLAADKIVDTNGAGDMFAGGFLGSLAQGKSLNESIEIGHKLGQMCCGQIGPKLVWPKENVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HXJ1</accession>
    <name>A0A1B9HXJ1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_05852</name>
        <name evidence="12" type="ORF">I206_107524</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI894014">
        <property type="protein sequence ID" value="OCF47986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009205.1">
        <property type="nucleotide sequence ID" value="XM_019157565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HXJ1"/>
    <dbReference type="STRING" id="1296096.A0A1B9HXJ1"/>
    <dbReference type="GeneID" id="30174221"/>
    <dbReference type="KEGG" id="kpin:30174221"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000013">
        <property type="entry name" value="Related to multidrug resistance proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF102">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="554"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="94"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="584"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="605"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="643"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCF47986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC73552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="654" mass="69454" checksum="5E8CFC1891F9E0C4" modified="2016-11-02" version="1">MSVNVGSTKPPISINETSNIPIRAESAGPSASPIWSASVESPRPPFADEDRRRKGSDVTLGSNGESPKEKKKGKGLTEGDEDVPDLPKNNLKLVMPAIGLVLFLSALDQTIVATALPTIAEDLGASPSQYSWVGTSYLLASTLQTPINGRVSDIIGRKPMLYAAIIVFTIFSALCGAAKSASWLIIARAFQGLGGGSIIGLTILVADIVPLHKRGTYQGFLGSSWGIAAVLGPILGGLLTEKASWRWCFYINLPTCGVAFVLLVFTLKLNPSRKLTFAELSRTFDFIGLALLMAASALLIVGFSRAADFGFGEPATYGVIIAGAVVFLAAIANFLTTKRNAIIPARMFKNRTTAFFLLASTLHAATFLAFNYLLPELLQGLRGDSPIDSGVHLLPFACCVAWMTVVAGQLNSRLRIVRPVVWAGYALAALAWGLFYGLFKSTVKLGTLEGVLVIGGIGTGLSLQVPMLIIQAAMPLKEMAAATSAWSLTRNMGGSIGLAVYTAILNTNLRSKFATIEGYGTSFIVPESAAGYKALHELPEGQMKDQVLEAFADSFRVCWIVGCAFFAAALFITIPTRSYSLNRARGGQAPTIQPPTDDVEAQNGQDEKAQAEEDEREVRDLDPPTGSSASSDKTALDIGDDGTIDRKGKSTESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HXP2</accession>
    <name>A0A1B9HXP2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_05904</name>
        <name evidence="5" type="ORF">I206_107571</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894014">
        <property type="protein sequence ID" value="OCF48037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009256.1">
        <property type="nucleotide sequence ID" value="XM_019157616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HXP2"/>
    <dbReference type="STRING" id="1296096.A0A1B9HXP2"/>
    <dbReference type="GeneID" id="30174273"/>
    <dbReference type="KEGG" id="kpin:30174273"/>
    <dbReference type="OrthoDB" id="60955at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061700">
        <property type="term" value="C:GATOR2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016239">
        <property type="term" value="P:positive regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037590">
        <property type="entry name" value="WDR24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46200">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46200:SF1">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="99"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="686"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="734"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="773"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="809"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="878"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="734"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="813"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="834"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="878"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="913"/>
            <end position="924"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF48037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC73599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1167" mass="128161" checksum="9553E4A070DF60CB" modified="2016-11-02" version="1">MNRLTNAFSSAIPSSGSDASSIHLRERDSPRVSSPLDPSFNVQAHPQQQRSSQSHSQDRRHVQNLIYDDPRTIYYPASSSKSGDRGFLTTLGLLNAGLSRPGRPGFLRHMTDEGSGKSTPRVRSESRSRERDRGVRVNLMNTAGLGGKRGWGMNSASSNTRLNAMAQGPEGRYAIGGGQYLRVMKIHDPNSGSTTPIFASDETKDRSTLAKGIGGVTISEVVNLWKPNWAVGKGVNDIDWGVGAFESKIVTATPSGNLMLFDVDKGKLDKDISSGTFRPMNCIRLCPSPSHGHLALTGGTEGGVRFWDLRERDPSNRKALKHSSPVTSLTFCPTDAYQFVTGLEDGSIRRYDFRSPSRSIGKAFGAHGSKTVLDLKWKEGDEDGDGTRGGGWLASAGADKVVQIWDMNQQWDKPPSPVHSLHTSHPVRKISWRPDHPTELVVVPLIQPLTTADSSLSPKPDSVTQSDYFSHEHQDEDAHLEIWHVRRHYIAKYAIPSQDGIAVDVTWSNGDNNLVACFQNGGFAQMEVKGKFGVGSLPLPLDQVPRQVISWSPKGEMVYAVDKFRMGEIPFDDVKPEYVNHWDKLGRPAPAMSIANPPYEPLQTLGFFPMPDTDGDEFAYLANWYKIEGDIPESLCRWNGDVALSLGRDDDARLWNFVRDLIVEFNPSENLSGEAGFKEDIFSGTMNSTARLPTPPNLSPRHGTPDLSSKFDVPYPSPAPVPLTRVDSSFFHSEDGISSSSSASSSVNSYSDSDSEEEEPKIKSRFLAFVPPDTLSSDLNSRKDSGGTVILPTGSISNTIRNMKFATNTTTGASTPISRSSSAESPPAPEEKGTMSNSTSKKSSLSKMTSSRIMAMSDWPDPYGIQADYSNTPTTIANTPALNNLSRDSPTPLDSSRILRNSPLPFSSLRKGSTPEEGSRKTSKDLTNQSANMVKIPTAIKADEEEFNRQEWATYRKRRLEALKKWWEGCIDDGDMQLATTIAIVGIAVGEFPAKQVERLAHSYVDMLERHRLPLPASYMRLYSNIPSLQIVPINEGITHKLHCGRCGKSTGELDDIGVEGKKFWWCKRCKLGAKVCAVCRKVVKGLWLGCRKCGHGGHGTCMRVYHNQAPLRPLVQSASNPNEILARTYVGTQTTMTEYSEENPIIENIGGWSVCPSGCGCKCRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HZ00</accession>
    <name>A0A1B9HZ00_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ACB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_05253</name>
        <name evidence="7" type="ORF">I206_107202</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC73236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009693.1">
        <property type="nucleotide sequence ID" value="XM_019156975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HZ00"/>
    <dbReference type="STRING" id="1296096.A0A1B9HZ00"/>
    <dbReference type="GeneID" id="30173622"/>
    <dbReference type="KEGG" id="kpin:30173622"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24124">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24124:SF14">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_25, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ACB" evidence="5">
        <location>
            <begin position="8"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="190"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="108"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCF48474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC73236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="246" mass="27240" checksum="03C1891CE45C1C6A" modified="2016-11-02" version="1">MSDKADQTQKEFVAASTWLSSAPSAASLSTDLKLELYGLFKFLNTHAGPEGNRPSIFSPAPRAKYDAWALQFAKYSPNQKAGQEMARQRYLEIARQVGWAGIVEEEEEDDIDLENLDDEPSNAGNRDKSQGRADNPIGGVKVSIMSGQEETEDDIESASPLHDAVSDDNRQIVQALIKRDPRTINLKDPFGYTPLHLAADRGHVEMVKLLLRHGADREAIDEDNQTPQLLAEISGRDEIVEILKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HZ73</accession>
    <name>A0A1B9HZ73_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF866-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_05333</name>
        <name evidence="5" type="ORF">I206_107123</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0587 family.</text>
    </comment>
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        <property type="protein sequence ID" value="OCF48554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC73157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="AlphaFoldDB" id="A0A1B9HZ73"/>
    <dbReference type="STRING" id="1296096.A0A1B9HZ73"/>
    <dbReference type="GeneID" id="30173702"/>
    <dbReference type="KEGG" id="kpin:30173702"/>
    <dbReference type="OrthoDB" id="10248838at2759"/>
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        <property type="component" value="Chromosome 10"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008584">
        <property type="entry name" value="CXXC_Zn-binding_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857:SF0">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05907">
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        <property type="entry name" value="MAL13P1.257-like"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF48554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC73157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="19299" checksum="5660909FAD1D6192" modified="2016-11-02" version="1">MELEGVKEVRPEDDYEFFFTVQCSSCREVHPKTVSFNQREEHEISGSKGTANFVWRCGNCKKEHSASFAPSNPSPKSKSKSIIPISYSSSESFQPLISLDCRGLEFIEFHINHGKWFAKSENDSSLKEFEINWDELKQQNEDRWDDYDDNSQQAISISECKSKIERA</sequence>
</entry>
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    <name>A0A1B9HZG3_9TREE</name>
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    </protein>
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        <name evidence="3" type="ORF">I206_107011</name>
    </gene>
    <organism evidence="2">
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
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            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC73046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009885.1">
        <property type="nucleotide sequence ID" value="XM_019157167.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A1B9HZG3"/>
    <dbReference type="GeneID" id="30173815"/>
    <dbReference type="KEGG" id="kpin:30173815"/>
    <dbReference type="OrthoDB" id="3215314at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
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        <location>
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            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        <location>
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        <source>
            <dbReference type="EMBL" id="WWC73046.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1B9HZH4_9TREE</name>
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            <fullName evidence="4">UAS domain-containing protein</fullName>
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        <name evidence="6" type="ORF">I206_106994</name>
    </gene>
    <organism evidence="5">
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        <lineage>
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            <taxon>Dikarya</taxon>
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    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
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                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="David-Palma M."/>
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                <person name="Bowers K."/>
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                <person name="Mohammad A.W."/>
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                <person name="Yurkov A.M."/>
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                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="Yurkov A.M."/>
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                <person name="Litvintseva A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
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                <person name="Zeng Q."/>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
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        <name evidence="5" type="ORF">I206_106885</name>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">CBS 10737</strain>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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            <authorList>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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            <strain evidence="5">CBS 10737</strain>
        </source>
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    <dbReference type="SUPFAM" id="SSF103657">
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
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    </evidence>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC72891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010037.1">
        <property type="nucleotide sequence ID" value="XM_019157319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I008"/>
    <dbReference type="GeneID" id="30173968"/>
    <dbReference type="KEGG" id="kpin:30173968"/>
    <dbReference type="OrthoDB" id="2534759at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38702">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38702:SF1">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF48818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC72891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="641" mass="70718" checksum="420D4D14A39A9ED7" modified="2016-11-02" version="1">MDNTNNSPTSSSSSSSFTQPSLQPLRNPKYRHISKSAAKRESVQMLGSIKDLQMHFASGGKVEHRPGAGIGIKGKSSLGILGEDLEGEENRPPSSLSDRRRPHPHKNIDLPRIDIEDARREAKSIIDDVRGIWGLSLPLSPSSAVNSNSSGLPSSKSLYFPINFDGDDEAHGENRTSEDIQSALVKTAQSIRRIRFLALSISHNSSNPTSSRSGILQSRLGGAGKIRSSLSTPSRPTGVPLRTVSNPNSAIMTERKTRGFKGDLLSELRKAALEVLTQLRELEESLRVSDRSKSPTEDRPFSPGTDEISGSGSGNGSGSGIFIEPDNYDSEEDELYNPNNLATNSEDTSHLTNWEDRILSEQREYKDLDDNSWEKEARGTREGMGKWVGVVEQLFVFTHEDGKKELEDWAKDSWEGSQLEQLHSFLLSNLPLDLTLPLPSTTSDNFDFTLLSRLSDGYILIHAYNSSLLKSTKPWGFIPDEDVHDTLSSSISISSDHTTPTKGGSREEGKQEKEWTFRKVGNLTCFAAALKHRYQLPIQLPITNLPVPSIPSKLTSARPRPSIDTSLSVSTGSIATTSVTKIEDKIEFDPMIIAKQSPGWETMLKLLIGKWMSAVIRELREVYDAPIMYMTRSTVDRGGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I018</accession>
    <name>A0A1B9I018_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thioredoxin reductase</fullName>
            <ecNumber evidence="8">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_05609</name>
        <name evidence="13" type="ORF">I206_106845</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="9">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="8"/>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC72881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010047.1">
        <property type="nucleotide sequence ID" value="XM_019157329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I018"/>
    <dbReference type="STRING" id="1296096.A0A1B9I018"/>
    <dbReference type="GeneID" id="30173978"/>
    <dbReference type="KEGG" id="kpin:30173978"/>
    <dbReference type="OrthoDB" id="371245at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000064">
        <property type="entry name" value="Thioredoxin reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050097">
        <property type="entry name" value="Ferredoxin-NADP_redctase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48105">
        <property type="entry name" value="THIOREDOXIN REDUCTASE 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0274">FAD</keyword>
    <keyword evidence="2 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 9" id="KW-0521">NADP</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="11">
        <location>
            <begin position="29"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="342"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCF48828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC72881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="368" mass="39720" checksum="570373B7AF726AA1" modified="2016-11-02" version="1">MAPIINGDHLNNVNEPKSKGEKSKKQHSQVVIIGSGPAGHTAAIYLARANLEPVLYEGMLANGFAPGGQLTTTTEVENFPGFPDGVTGTEMMDKFRAQSERFGTKIITETIARVDLTQRPFKYWTEGEEEEADFMTADTLIIATGASAKRLFLPGEDTYWQSGISACAVCDGAVPIFRNKPLAVIGGGDSAAEEATYLTKYGSHVYVLVRRDELRASKIMAKRLVSHPKVTVLWNTVATECKGDGDLLQSLALKNVKTGEESELKVNGLFYAIGHEPATSLVKSQLETDSDGYIKTIPGTSQTSIKGVFAAGDVQDKKYRQAITSAGSGCMAALEAERLISEEEAEDDEIKTEDVHVPSEGYMGADKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I1P9</accession>
    <name>A0A1B9I1P9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I206_05081</name>
        <name evidence="16" type="ORF">I206_106255</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC72293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010607.1">
        <property type="nucleotide sequence ID" value="XM_019156805.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A1B9I1P9"/>
    <dbReference type="STRING" id="1296096.A0A1B9I1P9"/>
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        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03273">
        <property type="entry name" value="ABC_SMC2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="RecF/RecN/SMC_N"/>
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    <dbReference type="InterPro" id="IPR036277">
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    <dbReference type="PANTHER" id="PTHR43977">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="14">
        <location>
            <begin position="524"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1177"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="220"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="686"/>
            <end position="921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
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            <dbReference type="ARBA" id="ARBA00022776"/>
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            <dbReference type="ARBA" id="ARBA00022840"/>
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    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1219" mass="135947" checksum="55B0EF169D198B5D" modified="2016-11-02" version="1">MRIEELILDGFKSYPVRTTISGFDESFNAITGLNGSGKSNILDAICFVLGITNMQSVRANNLMDLIYKRGQAGVTKASVTIVFNNQDRTKSPLGFENTPQITVTRQIAVGNVSKYLLNGHKSTLQALQNLFQSVQLNINNPNFLIMQGKITKVLNMKPAEILGMVEEAAGTRMFEERKDKAVKTMAKKDKKVEEIESLLREEIEPKLEKLRAEKRSYLEYQKATSELERLTRLVKAYEWTLSVEKAQKAAENLKSKKRDIQGAKEDVERGGRACEGMEKDLDEIRKKREKEMAKGGKVSALTDAVNNLDRELVKVKTQIEILEGTLKDDVNRLEGAKKTVQETEKTLEDRRAQTSEDASAFAELKAAYDGGQTELNKLEELLQSLITGLSSNKEDDENAGGYMGQLAEAKAKLAAAGTEAEQAKVKMGLAEKEIKEKEPRAKKAEKEGEGLIKELAAKKALAEKLRKQVENADWDEGKERELLELQAEHQSKITELVERRDTLKSRLAAIDFGYSDPEPNFDRSKVKGLVATLIDLNESNFKSSTALEICAGGKLYNVVVQDEKVGSQLLQNGKLRKRVTIIPLNKINAFKMSAEKLAAAKQVAPGKANLALDLVGYSDDVSAAMAYVFGDTFICSDKQSAQAVTFNKNIGVKSVTLEGDVYDPSGTLSGGSAPSSQGILIKVQELRSIEREINEHKKALDEVSRQLNGAKKVIDQYKKDKRELDLKEHEVRLLEEQVNGSNATKIISEVEHAKKVVAELKEVVTQAKEKQKQASADVKRLEKEMDDFKNNKDSKLKEIKADIANKKKELGKRTTQVKTRQKEVQTAELELQQLESDLETAKAEIDEALSAQEKTKSEHAELKATYKAQQADYKAAEAKLKAERAVLVAFDNELSDLEHDLKAKKQEIVDAELRLKKLDHDIGLVAKEQNTAEGHKENLERQFTWITEEHQFFGKSGTPYDFHGVNLNQARDQCRELETAQKGLGRKINTKVMNMIEGVEKKEQALKKMMATVLKDKSMIEDTIIELDRYKRDALTKTWEKVNGDFGLIFAELLPGNFAKLQPPEGQDLTEGLEVKVRLGSVWKASLTELSGGQRSLIALSLIMSLLQFKPAPMYILDEIDAALDLQHTQHIGQLFRNRFKGSQFIVVSLKEGLFTNANVLFRARFRDGTSIVERTERRSSNSLYSSSEDKENSQEITTAGGKGKRAGGASGRSALAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I1Q7</accession>
    <name>A0A1B9I1Q7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_05084</name>
        <name evidence="10" type="ORF">I206_106258</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010610.1">
        <property type="nucleotide sequence ID" value="XM_019156808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I1Q7"/>
    <dbReference type="STRING" id="1296096.A0A1B9I1Q7"/>
    <dbReference type="GeneID" id="30173453"/>
    <dbReference type="KEGG" id="kpin:30173453"/>
    <dbReference type="OrthoDB" id="295656at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000658">
        <property type="entry name" value="COP9 signalosome complex subunit 4, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF2">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="8">
        <location>
            <begin position="231"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCF49391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC72296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="465" mass="51905" checksum="32867D3FA87F06F3" modified="2016-11-02" version="1">MDSEIEQQLASISSTPNQKERTSSYFTLLSTLLSSSPLSPNELVTFGRHFVTSTSMAMVVGRRVLGTYVLALSAGTSMIKSGTSSLTFDDEGSGDNDKFEQLGIQAFKSEKGEEARRDIVEGVLAGGNLSGWCEEQTTVLRHLYSHLLQLEEDWLEAAKALMQIPLEGTSRLISDEEKLAVYIKIVRLLLECGEWGQAQTYFSRASLLIHVTKDKETNLSYKLSQARLFDFSARFNEAAQRYHEVSFDGAIAEEDRLQMLKAAVTTSILAPAGPQRSRILATLNRDDRVHTSLLPSLSTMLKKMLLEYIVRQEEVKEFESGLEDHQRATVEGGGTVLERAVREHNVGACGKVYDNISFEALGNILNLDAENAENTARRMIEQGRLRAWIDQPLQLLYFESRSAHDTDAEAQGTAGGLGIENKEKDIEPRLWSERWDDRIRETSIKVETLAEQIQQKGLIPPITTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I1T2</accession>
    <name>A0A1B9I1T2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA replication licensing factor MCM3</fullName>
            <ecNumber evidence="11">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I206_03976</name>
        <name evidence="15" type="ORF">I206_104443</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="11"/>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010674.1">
        <property type="nucleotide sequence ID" value="XM_019155716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I1T2"/>
    <dbReference type="STRING" id="1296096.A0A1B9I1T2"/>
    <dbReference type="GeneID" id="30172345"/>
    <dbReference type="KEGG" id="kpin:30172345"/>
    <dbReference type="OrthoDB" id="1882346at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000018">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008046">
        <property type="entry name" value="Mcm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056575">
        <property type="entry name" value="WH_MCM3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF46">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23191">
        <property type="entry name" value="WHD_MCM3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01659">
        <property type="entry name" value="MCMPROTEIN3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="310"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="686"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="696"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="717"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCF49455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WWC70492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="862" mass="95203" checksum="CD7850357DCA935B" modified="2016-11-02" version="1">MADNLPSTQDIMPVLADDLMRDRARQFVEFLDDDTQANYNYRESIKRMLDLEQVRLIVNLDDLRDYERSYADGLLLQPTSYLPALDAALTQLVQSLHDPVKHKIAGNEYYVGLRGSFGQQHCNPRTLRSHQIGRMISLEGIVTRCSLVRPKMLKSIHYCQPTGKFHSRSYHDATIIAPSSTLTGSTTVIPQDDGEGHPLLMEYGLSTFRDHQTISIQEMPERAPAGQLPRGVEVVLADDLVDCCKPGDRIQLVGVYKSSGGGAGARGFQTSIIANNIILLSSKQGGGIAQTPLTDTDIRNINKLSKRKNIFELLSQSLAPSIYGSDYIKSAILLLLLGGEEKNLKNGAHIRGDINILMVGDPSTAKSQMLRFVLNTAPLAIATTGRGSSGVGLTAAVTTDKDSGERRLEAGAMVLADRGVVCIDEFDKMSEVDRVAIHEVMEQQTVTIAKAGIHTSLNARCSVVAAANPIYGQYDVHKDPHRNIALPDSLLSRFDLLFVVTDDTDEQRDRLISEHVLRMHRYLQPGVEEGAPAIENLTQNLDVGGDEAESRITETPVFEKFNPLLHGGVTTSSGRGANKKKEVLSIAFVKKYIQYSKSRIHPTLTKGAADWIVSVYSALRNDDLAGNQKRTSPLTARTLETLIRLSTAHAKARLSSSVDERDAMAAEEILRFALFKEVLKPERRKRRKLNAGVSVDSDEEEEEEDEEEVTTGGVTDSQRERAREKNRRMEGGPTLRGSTPRSAPTPARDQRAVEDEDDIDMEASLALAEAEAETAVPAGSGIEETDVEISNERLDLFRNRLSNLFENELDADGMIDLQDLVPKINEGLETNELFGNREARTAVQRMNDRNEIMFAEGTVYKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I1V6</accession>
    <name>A0A1B9I1V6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable methionine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="2">6.1.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I206_04057</name>
        <name evidence="14" type="ORF">I206_104364</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="2"/>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010755.1">
        <property type="nucleotide sequence ID" value="XM_019155797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I1V6"/>
    <dbReference type="STRING" id="1296096.A0A1B9I1V6"/>
    <dbReference type="GeneID" id="30172426"/>
    <dbReference type="KEGG" id="kpin:30172426"/>
    <dbReference type="OrthoDB" id="24670at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.220.10:FF:000001">
        <property type="entry name" value="methionine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023457">
        <property type="entry name" value="Met-tRNA_synth_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326">
        <property type="entry name" value="METHIONYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="12">
        <location>
            <begin position="60"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="12">
        <location>
            <begin position="209"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="561"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCF49536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WWC70413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="581" mass="65549" checksum="274C6648C112EFC2" modified="2016-11-02" version="1">MRRHIPRIFAPCRPRVITAARPPLIFSLQPYSTASSEASSSRIPSLFTPVDDLSISKPFYITTPIFYVNAAPHIGHLHSLLLADVLARFSRLRHPERKVIFATGTDEHGMKIQQAAKARGIDEQAFCDDVSERFRDLAKLANSSNTDFIRTTEGRHQLAVEHFWGKLVERGDIYKGTHSGWYSISDESFYAASQVVKRESDGVMIALESGNEVIWEEETNWKFKLSSYKDFLREWLSKPESVHPPSVRQHLLSQISNLEDLSVSRPKSRVKWGIPVPNDPEQSIYVWVDALINYLTVTGYPKETSGWPADVHVVGKDITKFHAIHWPALLTSASLSPPQRVIAHAHWTMGKSKMSKSKGNVVDPIQSMRDWSVDGVRWYLMRIGGSLTDDADYAPDQVEVHYRILADQFGNLLSRISGNKMLKKANRELDFSSPNSEDRDTDLDSLLSNLKGEFENKMENYNISGACASVMEVIAAANKLFTNLAPWSAEDGTKAIIYAYHTLRISSILLQPIIPTKSNEALDRLGIPPDQRTWKDANWSSRNVLLSTKEIVDRLRSGSKEWKGKGHLFPLPERGKSNLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I2Q5</accession>
    <name>A0A1B9I2Q5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Acetoin reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_04272</name>
        <name evidence="5" type="ORF">I206_104153</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
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        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
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            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
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    </evidence>
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        <source>
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    <name>A0A1B9I302_9TREE</name>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 10737</strain>
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    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="OCF49917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
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    <accession>A0A1B9I376</accession>
    <name>A0A1B9I376_9TREE</name>
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    <organism evidence="2">
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    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
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    <sequence length="1431" mass="157775" checksum="D2EC24A025E9D858" modified="2016-11-02" version="1">MTISQRSSNKVFHQWSSSHERSSPSNAEPLMPITPRHHNVSHTSHKNRFGDVKGYYHPESNLKSDNRAIKVPGLNDLHPTNTPGSPSQIDPFGSQVNLPSPIPPHHSLKPSRPPSTVLSSDGSPLPESNNQAVTPRITVASPSTSTIHYLFPSSDTRTGIHLTNNSTTTASTAIVVEATSNGGTSDVKLKRGYSLTRGNSLKIKTRTHSPTESNLNHRDIPGLTNKRSLPTPNLKQQEVLTGSNKTAQMNRGGLKRSDISNPYPSLSDEARDYSKGYYDVGPEQDTMGTLRRQPGMEDLSGKSRLGITERSELKENLGGIRRRESIILKEIENRRDKRGWEIGHNKAIEQKEMSSMYSKPKTSVSKDQDRKQREKPNIPPITIIQQRRRSQSLSSPRPAPCPPIDPARSPLIPAPDLGDPLSLSVVMPSPSYSHLDYSPAGSSACSTNSLSRSISKRGIAWGKRASVIFPVPSSIRMSRGDTRKDLGDYDSAKLKVKQDYENRTAAHGVSNGKLGRIASIKRTVSLRKKDQQDSQPIRRARPRSQSLTENRILKSLDEAPPLPSPSMMKRGYVPYGQEYASSAYTGELSLDFGDRYYQDNKSTTTLEMELTSPRSVNTSYFPGSTPTSSDFNHIKGRNAIRIVGKPLHPALNNRSDDSLSISAPSTVGLGFSPVGTPVSLPGSLLEEMIDLTDTGLGDRRVSSPMIESVITPPTPQNQGTLPAPGLLLTHIGFDDSSEDIAASTPGSQSQRIPRRSVLLAQNRFYIPPPANSSKLSKPKQEPDLGERPFLRSSKSMGQGLMKRAYTSGNLKVDANKQSSCQSTEEGKPHGSSGLLKSASIRSSTQSFSKLSDDQHKNGKERQYGTERISSTHSMKFKSRPLTTFSICSPPDAIDPLPYTSPYCAEGRNTPSTSQRRKSLRSNKSSPFLSASNSLRVIFGKEGFVARCLSQAFEKDQSNDRNQSPQHTNPNKRERSFSPEMTKEELKMKISSPLEASTVSSRRNESPVYHQESSKRALSPQYEQAREIGRNADKKWRESVLQEALTLSISNSSLNRLANESELENIDMPRMVSSGSKNRLAIPGQLLSAPTITINNNNERDTDPIHHDTSDGYAGIGQSMLQSQNSLESSLNLRAIMEVENWDLIPPTRTLGVVGKEESLVSAPSMYSNNASTLYEKPSSSSKRLVGKGFPTSFSIADLTKRNTSKSKNIYPTKQQDGDLENTLNANNISQPIPILTPMNYNSSLTKTFDLQPSYMIKTDQTDTHEETRNAGSIWNNKSSFLKNRSSSRSNTPDPANISRSVSPIQSQSTQTQTPDGSSAWKLSLKSSIKQKRSGISSNDLLQDKTQPIHPKQTENGVLNELLTRDQIHPQSNNNEVVDGNIRETNKLNKVLAWRNEVDENENLAQLDQKIRGFVSDERERVRGIGRKSIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I3M6</accession>
    <name>A0A1B9I3M6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_03415</name>
        <name evidence="3" type="ORF">I206_105683</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019155163.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="kpin:30171784"/>
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        <property type="component" value="Chromosome 7"/>
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            <end position="87"/>
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            <end position="288"/>
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        </location>
    </feature>
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        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF50098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC71725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="365" mass="39784" checksum="83E550BAF25C4C80" modified="2016-11-02" version="1">MIMTSSPILTPSCRSIAHTPSPSSSPQLRPVASTMIKPTSNTSSSSSAPSQNPFSTSNGTTITASSLPTRSFVRGPQARPYLATKTPKTVEGDTRKFADLVSKMVNQFDQQKRKEELIEMIENVNLSSSPKPILGGSLNVPKRNKSIGGGSLAGSWEVERAELIVDIPVWSPGCFQDLSTLHALRDTTLSHTHALLSHLLNVHNTPATYRLLARSCVQPNHHDHTSHHHGWGCIRLAPSISSPISAPLELKPRERRASLVHTRSSPNTRLELGGAGAGRGNSKSPTRYGQMINDKVIVESEDEEEFEIKLREGYSRSNISTDSESEDDEEESADFIVGREIEKRGGKEGMAFLMTLFGQPALILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I4F7</accession>
    <name>A0A1B9I4F7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_03722</name>
        <name evidence="11" type="ORF">I206_105369</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC71413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011620.1">
        <property type="nucleotide sequence ID" value="XM_019155466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I4F7"/>
    <dbReference type="STRING" id="1296096.A0A1B9I4F7"/>
    <dbReference type="GeneID" id="30172091"/>
    <dbReference type="KEGG" id="kpin:30172091"/>
    <dbReference type="OrthoDB" id="436852at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Spp1/CFP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
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    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
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    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174:SF1">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
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    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="9">
        <location>
            <begin position="597"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="280"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="418"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="782"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="734"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
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            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="345"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="375"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="443"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="482"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="542"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="563"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="573"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF50401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC71413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="919" mass="100905" checksum="9E840C20291F4E8F" modified="2016-11-02" version="1">MPRNLEVNEDEGRESSVDPLDLIPRRPSRSTSLIPEVVIPQSRSRSTPKSRSSISNSTSRSVSPVKDSNKGPRGRGRGRGRGRGGNRSSQSKSKSKSPEKRSKIVLPLVNESDAGSHGDQQESELIDDRENVKRRRLNSQEPVLSPENKYVIVANQQSAEESVNSDAIDTEANPGMHEVKTENQTYTEDTQPPIPTQADLPQVSPTLEDTQEDDIPNHDIPMEVAQNLPTVPVAPMQATEVLNDQTSISESLIDSSGETTKEPKDLVAADVQDSLKIENEELVEQPILEQNNTTADEDDVEAANTEKQSAVSLVDRLPQDEDMEGSRVHPDTALEGFTEQPLEDDEKKESVDTKNAGEKLAIGSLNEDQATQAVSKEERPLKEEDVGPVAEDSIVESAVAAEGADLGNRQFEQEELALEAETSAQTENMDIDEVNTTTGMVVDQEDENEEVAQSEGEMELEDFPQEDNDVEEIQAEDDAPSSRRTPTATPAPSSPAKSISTSQASTSKSVKKTASTAAKKKAEGVTGKGKKVSIPSSTNKGTGKKGTGKGKGKTKVEELKATSKASSAIFNETSQPTTPTRPTSSYNSPNPSPDKNAVYCVCRKPYNEEDDDVLMVGCESCDNWFHPDCVGLTEDLVDALDVYICKSCERSTHQYTIYKQLCKREGCSKSVAGRSSKFCSLSCAFQHSQSLIAAISNKNTLKQLAKTFISYPEPKLGVNVLNHAQAEKPAKKSQESSVDRLSDLEKQLKKVEEARRLVVKRQKILEFAVERAENLPTINNFPEEQEEEIEEPRKKGKKKKLNGASVGGVKDDRPCGWSKRLILGDEELLSSDQNGVELDTGNGQEVDGDVCMRGKRRCDRHQGWQKTIAVQLEVELSSLERIQKRLNNYVDGIKSTNEVESFSNEIRNGFMERKGLHKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I5D8</accession>
    <name>A0A1B9I5D8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_02800</name>
        <name evidence="12" type="ORF">I206_102450</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF50744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011963.1">
        <property type="nucleotide sequence ID" value="XM_019154560.1"/>
    </dbReference>
    <dbReference type="STRING" id="1296096.A0A1B9I5D8"/>
    <dbReference type="GeneID" id="30171169"/>
    <dbReference type="KEGG" id="kpin:30171169"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050973">
        <property type="entry name" value="H3K9_Histone-Lys_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007728">
        <property type="entry name" value="Pre-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223:SF3">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SET-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SUV39H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05033">
        <property type="entry name" value="Pre-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00468">
        <property type="entry name" value="PreSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50867">
        <property type="entry name" value="PRE_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Pre-SET" evidence="10">
        <location>
            <begin position="1205"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="9">
        <location>
            <begin position="1279"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="39"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="190"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="384"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="461"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="688"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="957"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1450"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="235"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="399"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="967"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1002"/>
            <end position="1018"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCF50744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC68521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1505" mass="163273" checksum="B54FD4FB3377AEFD" modified="2016-11-02" version="1">MEDTGNSREYEKAIDVNRSYIMSIPNRAVGNAVDPISLDWSDEEIPSSSQAGPSRRASRPSAATPSNRRTSILVDLTLEDSGSDTPRPPPSSRTPSHQPNSSKTSRGIPPNKHRNAEDTSGPSVGPSRKVKEEALGKPGSWTNPTVLDPSALPSTSSDGKEAMRSPTDANMAPQGSWLNPAVYVPHIPVAPSAPEVTNKGKGKGRQTGNEPEVGNWLNPRVLDMSGSPTKEDFNLPSNWTRNEPNASTQRGRESQGTSVTQVRSSDDMDNPINPILRGLSASPISRDDNNGLESTTDVFVDLLPQTEFDQQPPTTSTYPPPSPPHSLLPKLSVGAILPGDALSSDSQPPAGSWLNPTILEATGPATSASLEGEHEVGSWLKPAVLEAPASHKRSASPTELEKEETSRKGKARRIEVTALEDLNIAKSPEPPALTVKKGPTWVTSEQPVKKAQSIEATAISAVAQEIPTPRDVSESQENTPKDINTIDNTEIADDSMFVDPIHSIVKTPESQLLPISAVRQEDLPITEAEILVPHTTSTDQPSSSDVPIGVYTSPGQPAAPVDQPLTSLDQEMPHVDVEHTTLGQISAISEGLTGHAVKSNQEEGNAVTAQMEQDKENLFVSAPEDLEAMDVDHAGQDEIKVAQLEVDNSIIQDDSSKDSSVPSMTMTTSANTLEFDPGTLHAVQHKAVGPPTQDKSEGADQEQSSPKAIYIPQTPEISIPRTPLTNDSQEVEASLALSIISPIAEFTAKSSVLVESRPEPIALPPPIVGHNDVPVTAAHLDASRAQTTSAYLVETERTIPPEDVPETGITYPVSSPTIQPLPVLSYNPSPAPESNVAVIFQRDIANEVDVKPILELVPLINTTGHGSSSLNPITLDLDDDDLDFLNSDKEDGSQDTMDAVLEQKAEDARAGDSEFEIVPLPVNFPVVDIDDRTRRSSSVPSIEEIKGDDFIHRIGTQSARKSTRTKQQAGTSASAQAALTDHSSKGIFSGSRLLPNRMTIPSAAASQSGSSPVKKSSVTPPPRFEIVIPTRSRQQWRHIVENDGDSEVEDILDDHSNDSSSSGLSKAVDLVEYNGFTVHNTYRIPASEDAMDISTESTNLHTIAASTMPDPLPPSDRIGIANRTLNTKLIDEWNKRKPHLTSNPPLHRAVFEAYMAQSTSIDEPYADEIRVVNDVDSEGAPPDFEFQYSNDMLYNPDVPDPELGIGCDCDGPCDPNNEKCSCVKRQEAYFYDLGMKGFAYDKHGRIKETSVSVWECGKHCGCPPDCQNRVIQRGRGKDTKIELFKTRWKGWGVRARAPIEAGTFLGIYAGELITEEESEERGKLYAQIGRTYLFDCDGWQISHPPEGLEQVDHRLAQLAELAAERARLVATEADDPSWVYSAYSVDAFHYGFTRYFNHSCDPNLAITQAYVKDFHPERPILVIFARRAINRNEELCISYKGLPDEDEIPIPAPQPKLTTRNAKQKKSKTSASAHITGGTKGKVAAKDRCMCKTPRCDGRMFSYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I5I5</accession>
    <name>A0A1B9I5I5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pali-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_02834</name>
        <name evidence="3" type="ORF">I206_102483</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF50778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011997.1">
        <property type="nucleotide sequence ID" value="XM_019154594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I5I5"/>
    <dbReference type="STRING" id="1296096.A0A1B9I5I5"/>
    <dbReference type="GeneID" id="30171203"/>
    <dbReference type="KEGG" id="kpin:30171203"/>
    <dbReference type="OrthoDB" id="3881at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051380">
        <property type="entry name" value="pH-response_reg_palI/RIM9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013:SF4">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF50778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC68554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="26145" checksum="2B93838B708BFCDE" modified="2016-11-02" version="1">MLARAAFPAFFLSLGGFILLLLVTLSVPIIKTIYLLQVRIKQGNSIGSTSLGANAGVFGLCYQGGQASILGFEYSSNAGCTDPHVGYTFDENLLGLSNSGLSKAVIKGVAGALILNAIAAGLAGLSLIWSFFAWLCSSRGWEIFTFVSLFFAVISAWLAWALDLALALVARHRIEDASNDVLDARIGNGVWIALGGAVALTLALCFAGCGMFGRFGNERNPTHKPVSYRRRHFWQRDQTGRGTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I5Y5</accession>
    <name>A0A1B9I5Y5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">IMD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_02962</name>
        <name evidence="4" type="ORF">I206_102608</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF50901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012120.1">
        <property type="nucleotide sequence ID" value="XM_019154717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I5Y5"/>
    <dbReference type="STRING" id="1296096.A0A1B9I5Y5"/>
    <dbReference type="GeneID" id="30171331"/>
    <dbReference type="KEGG" id="kpin:30171331"/>
    <dbReference type="OrthoDB" id="5594612at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000075">
        <property type="entry name" value="Related to IVY1-phospholipid-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037470">
        <property type="entry name" value="IVY1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38407">
        <property type="entry name" value="PROTEIN IVY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38407:SF1">
        <property type="entry name" value="PROTEIN IVY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="278"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="146"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="278"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="290"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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                <person name="Heitman J."/>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="Sun S."/>
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                <person name="Mohammad A.W."/>
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                <person name="Yurkov A.M."/>
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                <person name="Litvintseva A."/>
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                <person name="Gargeya S."/>
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                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="David-Palma M."/>
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                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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                <person name="Litvintseva A."/>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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        <text evidence="9">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the EAF6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00010916"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018504"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF51783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC71007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="120" mass="12935" checksum="BF99F13BDD2D482E" modified="2016-11-02" version="1">MSQSGPPADAKQAQAAAMAELEAAQRKKRAIDSTLANLENSIYAFEGSYLDETAASGGNIIKGFDNYLKPPTTNLNKKKIEVTEGDRLFSTSSGTYQQSLVAKRQYDIEAAALNNKNSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I8R4</accession>
    <name>A0A1B9I8R4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ASTRA-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_02579</name>
        <name evidence="8" type="ORF">I206_105039</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat ASA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <location>
            <begin position="11"/>
            <end position="52"/>
        </location>
    </feature>
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        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="OCF51863.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC71086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I8T9</accession>
    <name>A0A1B9I8T9_9TREE</name>
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        <recommendedName>
            <fullName evidence="8">NodB homology domain-containing protein</fullName>
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    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_02599</name>
        <name evidence="10" type="ORF">I206_105059</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
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        <lineage>
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            <taxon>Tremellomycetes</taxon>
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            <taxon>Cryptococcaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC71106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013102.1">
        <property type="nucleotide sequence ID" value="XM_019154362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I8T9"/>
    <dbReference type="GeneID" id="30170968"/>
    <dbReference type="KEGG" id="kpin:30170968"/>
    <dbReference type="OrthoDB" id="3162524at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10938">
        <property type="entry name" value="CE4_HpPgdA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037950">
        <property type="entry name" value="PgdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561:SF1">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="8">
        <location>
            <begin position="32"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCF51883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC71106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="302" mass="34124" checksum="5526411E9DBDDCCE" modified="2016-11-02" version="1">MTLGGRKLISFGIDVDAVAGWLGSYGGEDSPGDISRGMFAGEVGCPRLLKLFAKYNLKTTWFIPGHSLDTFPEEMKAVRDAGHEIGLHGYSHENPTAMSAEQQRDILEHTFKQLTEFCGKPPVGSVAPWWEVSKEGTEMLLDKGILYDHSFQHHDCLPYYLRTGDSWKPINYKEQAASWMEPLKKGETTGMVQIPANWDLDDLPPMMFVKGSSNGFVDARTIENKWKDHFTYCLREYPDGFCMPITIHPDVSGRPHVLMMLERFIEWVNTHDGVEWVPMKDIAEQFRKSNAPPEGAVMPKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I9A4</accession>
    <name>A0A1B9I9A4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquilin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_01404</name>
        <name evidence="5" type="ORF">I206_103593</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013338.1">
        <property type="nucleotide sequence ID" value="XM_019153177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I9A4"/>
    <dbReference type="STRING" id="1296096.A0A1B9I9A4"/>
    <dbReference type="GeneID" id="30169773"/>
    <dbReference type="KEGG" id="kpin:30169773"/>
    <dbReference type="OrthoDB" id="267397at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16106">
        <property type="entry name" value="Ubl_Dsk2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015496">
        <property type="entry name" value="Ubiquilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677:SF3">
        <property type="entry name" value="FI07626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677">
        <property type="entry name" value="UBIQUILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23195">
        <property type="entry name" value="UBQLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="11"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="350"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF52119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC69650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="403" mass="41057" checksum="7B479B74E5DEF597" modified="2016-11-02" version="1">MSDSAASSSDITITVKGPSELKLSITISPDKTVTDLKEAIAAKSDVEKERQRLIYSGKVLKDEDAISTYKIQNGHTIHMVKGAAKTNNPTPTSSAGSGSSPAAVPRLPQMGTGLNVGSNPIDNVENIHHGLAGFNPFAGQPGLDNMFDPNAMTGMMNNPDFMRSMADMMARPEVLDQIIASNPQLQAMGPQVRQMMQSPFFRQMMSNPEALRAMMQMNASMGSGQGGFGGAGGFNPFGGGFGGAGVGTGGQATGGEGQQAASDPFPNLFAPQAPAATTNTNNPSTPSGTAQQPPNPQANPLAALFGGAGAGAGLGAGGQGGNPFGFDPSLLFGGGAGGAGGFGGFGSPAPRDERPPEEIYATQLGQLNAMGLWDAQKNIRALRSTGGNVEAAIELIFSGQLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I9C1</accession>
    <name>A0A1B9I9C1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7 8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_01494</name>
        <name evidence="12" type="ORF">I206_103502</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the PPP phosphatase family. PP-Z subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7 8"/>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013427.1">
        <property type="nucleotide sequence ID" value="XM_019153266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I9C1"/>
    <dbReference type="STRING" id="1296096.A0A1B9I9C1"/>
    <dbReference type="GeneID" id="30169863"/>
    <dbReference type="KEGG" id="kpin:30169863"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000006">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011159">
        <property type="entry name" value="PPPtase_PPZ/Ppq1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF484">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE PP-Z1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000909">
        <property type="entry name" value="PPPtase_PPZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="326"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="514"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="522"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCF52208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC69560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="536" mass="57495" checksum="E0475102971FA0C3" modified="2016-11-02" version="1">MGQGQSSSKKLGRTSSKQLSTSDLADSLANTTISSGKVIDGPSSPGSSPSMEISNNGQFSTPTRVSGRRNGSGKEKTGSISSFSSASAGTNRPSLNTQNSFDGSSSVNTSTNASTSSPTSISTPSSNIPTTQNILAAPKTRSSLLGHSPPPPSALSVSPGQPGSPPLNSPSQSLGHMQRDSTSSLSPGAALTATISRSSIGGTSAGGVQVLDVDNMIHRLLEAGYSGKVTKSPPLKNAEIASVCAAAREVFLSQPTLIELSPPVKIVGDVHGQYADLIRMFEMCGFPPSANYLFLGDYVDRGKQSLETILLLLCYKIKYPENFFLLRGNHECANVTRVYGFYDECKRRTNIKTWKTFIDVFNALPIASIVASKIFCVHGGLSPSLKSMDDIRRIQRPTDVPDYGLLNDLVWSDPSDTALDWEDNERGVSFCYGKSVINAFLATHDMDLICRAHMVVEDGYEFYNDRTLVTVFSAPNYCGEFDNFGAVMSVSEDLLCSFELLKPLDGAALKKEMTKSKRKSLQNHQSPPNNPMAQSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I9L7</accession>
    <name>A0A1B9I9L7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_01535</name>
        <name evidence="13" type="ORF">I206_103462</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Intramembrane glycolipid transporter that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. RFT1 could mediate the translocation of the cytosolically oriented intermediate DolPP-GlcNAc2Man5, produced by ALG11, into the ER lumen where dolichol-linked oligosaccharides assembly continues. However, the intramembrane lipid transporter activity could not be confirmed in vitro.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the RFT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:glycolipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="RFT1"/>
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        <property type="entry name" value="ENDOPLASMIC RETICULUM MULTISPAN TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PROTEIN RFT1 HOMOLOG"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF04506">
        <property type="entry name" value="Rft-1"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="120"/>
            <end position="141"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="388"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="505"/>
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            <begin position="1"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
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            <begin position="8"/>
            <end position="22"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="EMBL" id="OCF52249.1"/>
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            <dbReference type="EMBL" id="WWC69520.1"/>
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            <dbReference type="Proteomes" id="UP000094020"/>
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    <sequence length="550" mass="61032" checksum="BD1A3BF6197EEF6A" modified="2016-11-02" version="1">MTSSTIPDHVKDVQPEERKLEQDASPTASSNPLRTAKSLVLLQLLSRLLTFSLNQALLRLASPSVFGTAAIQFDLICSSILFLSREGIRNALLRTKSTDQIQSKSDSSEKEDVAEKQIQALSIIPIRLGLFISLILGSIYIYSSDRNTTTQAYFHTSLGLYILASLMELLVEPLYIQIHRSNPPLLNIRVQAEGGMAITRSVITVASLVLLGENRALLGFALGQVGGATWLVVRYLREFDWNVRTLLWSKSVTVDGENRYNPQTLSLAIANTGQSLIKHLLTEADRIAVARICPLDGQGGYAVAMNYGSLIARIIFQPLEESLLLHYSTSISSSRMSGKSSVLRLYSLTIRSSLYLTCIILTFVPTLYSAISPILLPRQYQNTTAPAILYLYLIMYIPLMSLNGLTESFVTSSATPQQIRKQVRWMIASSGIFALTLLSLTKDTKLVSYNNRPNWSTWINPTREEALIFSSCSAMLVRIVFSLSHAKDFFGSEMRIINLIPNMRVTIWGSLVTFVLNTLAQTGRWKNGWKGWVELIGSGGMLGLLTLGFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IAR4</accession>
    <name>A0A1B9IAR4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I206_01811</name>
        <name evidence="14" type="ORF">I206_103185</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat ELP2 family.</text>
    </comment>
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        <property type="component" value="Chromosome 4"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Elongator acetyltransferase complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="Elp2"/>
    </dbReference>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
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        <property type="entry name" value="WD40_repeat_CS"/>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="51"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="105"/>
            <end position="146"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <end position="546"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF52520.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC69248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="827" mass="92474" checksum="7F20FD4DB8016032" modified="2016-11-02" version="1">MRVDPKYISIGSNRSSSCSVCTSKGILAFGAGKFIALWNTENNSKGVYKTLNGHNAQVTTIKFINNNENLISGDRQGEIRIWSKDNEKNKKEEEEEEWKCKFNWIAHSNSSISSIGISPDGKFILTGGSDSTIKIWNISNQDKIEEIQKIDLKSKLPLDLELAYLPESKTPVLAVGCTDKLIRIYTLSPNNEFIHTLSLEGHEDWVRCLSFTTYPSPSDASKEDLILASGSQDNYIRLWRVSSIPNQPEQDKPIEQDNKKEGLDLLDEFERRLNGEGSGQISTKAHVMVVQDGGKSLRYNITLEALLVGHESGLTNVHWSPPSSTSSSPLLLSTASDNSLIIWVPSSASTESDGIWVPEHRFGAIGGRGLSFYGAIWGKNGQSVIASGWNGGLERWVKITDENNEEIWEVRNGVNGHYGDVQSLTWDPRGEYLISVSSDQTSRIHAKSSTSSNTRWAEIARPQIHGYDMTDIAFISPLRFVSSADEKVARVFDAPEGFVESLRTLGVSSRNRDEEGARPKGATVPPLGLSNRALQKAPAESEKVEKQGQNEAIISISHTLTSLPTEEELATSTLWPEIEKIYGHGYELVCVASSYDGKLIATSSKSTNLEHSGIRIYNTKNFESFGNILQGHNLTVTRIQFSLNNKFILSCSRDRSWRIFKYNPEKEKENEKEKEGYEIFVEMEKAHSRMILDCCWADSFDCDNLFATSSRDKTVKIWIPSIKDKSNWKVSEIIKFNEATTSVSIISPNINERKYLLAVGTEIGSISIYTLDIIEEEVKSKELIIFDESISHVGPVNRLAWRRKDDGKLQLASCSDDRSVRVFDVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IAT6</accession>
    <name>A0A1B9IAT6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_01886</name>
        <name evidence="8" type="ORF">I206_103110</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013812.1">
        <property type="nucleotide sequence ID" value="XM_019153651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IAT6"/>
    <dbReference type="STRING" id="1296096.A0A1B9IAT6"/>
    <dbReference type="GeneID" id="30170255"/>
    <dbReference type="KEGG" id="kpin:30170255"/>
    <dbReference type="OrthoDB" id="2564889at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF32">
        <property type="entry name" value="ARGININE METABOLISM REGULATION PROTEIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="645"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="256"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="560"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="778"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="836"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="8"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="357"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="560"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="573"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="847"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCF52593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC69174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="879" mass="95885" checksum="EA8D13D96DB52265" modified="2016-11-02" version="1">MSYQYHYQQQQQQQQQQQQQQQQQSQSQSHDNPSSLPFDTSNIPLTSTSTNNPPEYPETYLQRLIREKQGGPSNPSSWSCNQYYIHNDYCSYEYNANIDSRDIYYPSQGSEMSAIAALPPQNHIMSNPQHTVQKNSMNYPSQVSIQQAIYPSAPANTQSTIQSKASARSSRFQQLLNTKVAAEQRMRELTPQNDVSQDTVMGDEQLKFAQAQMSQQATNTVFHKEFIGAQYAHEGFQQLSQYQAPVKNTALFPQQSPISYTNDQNPYSSYSSTSPSIPMTHQQAQISRRPVSQTQQPQNHPYTDRAYQGQNLIPDVHSSFDSSQLSSSPMQTKSQLPGQSRSGPYNQNPTYPHAQVNGDSNVGADQSNLTSSPAAPHRQHLLPSQQWMQNAGINGWVTTVAPSRTPSISSNPPQPSPHVQAQVQSQPVPSFAWNVSDTGSAEDIPSFNTRTSFDRTPGLTPSAPFLTANDSTSSLPVTPTSSALYMRAQASNSTPYITVKTEPDTQHLGVPCAHNSHIPSPVATSPSRAYNTSPLLDYGARMFTNMNGSLQLPGPSMYMSSTNGGDPTNLNGLAGGIGGGFGETGGGSGEDWSNGGEGSGSGSGQDGSGSGAGGGHDGNGNGSDQGGNGDDGSGGMRKGKKLTLACHFCRRRKLKCNGAQPKCDNCTKRNETCTWDNNVRRRGPGKATKERREKAAREAISAGLTNSDSLRASLTEDESIHLTSANDIHHHQHNHDSIGELPIVDALSSVLQDGGVGREGQDFEAQLVELERYNRQQQEQFDQPLHHQQHHQEQGNSYDIGKQDELVRLTEIDPDMPIDPALAALSAVIPSTLAELEQPNSSSNLIEQREKRRSVEVGDSSNGNGVHKKLKLEETTFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IB05</accession>
    <name>A0A1B9IB05_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Succinate dehydrogenase assembly factor 2, mitochondrial</fullName>
            <shortName evidence="3">SDH assembly factor 2</shortName>
            <shortName evidence="3">SDHAF2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_00131</name>
        <name evidence="6" type="ORF">I206_101192</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with the flavoprotein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDHAF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF52835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC67284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014054.1">
        <property type="nucleotide sequence ID" value="XM_019151916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IB05"/>
    <dbReference type="STRING" id="1296096.A0A1B9IB05"/>
    <dbReference type="GeneID" id="30168500"/>
    <dbReference type="KEGG" id="kpin:30168500"/>
    <dbReference type="OrthoDB" id="284292at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.250:FF:000004">
        <property type="entry name" value="Succinate dehydrogenase assembly factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.250">
        <property type="entry name" value="Flavinator of succinate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03057">
        <property type="entry name" value="SDHAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005631">
        <property type="entry name" value="SDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036714">
        <property type="entry name" value="SDH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028882">
        <property type="entry name" value="SDHAF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12469">
        <property type="entry name" value="PROTEIN EMI5 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12469:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03937">
        <property type="entry name" value="Sdh5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109910">
        <property type="entry name" value="YgfY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF52835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC67284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="175" mass="20556" checksum="1B0C995F11AE1C73" modified="2016-11-02" version="1">MSSIRILTRSFRSTNIPSTSYRSFSINYKLLKDSIDPFPLPFSNPELASNSSSRLPDDSEEWPIPSPLDRTGENLQTLRSRLIYQTRKRGTLETDLILSTFAKEFLPTMSYDEMKEFDKLLDEPDWDIFYWAVQKREPPPKWKDTSLLKKLIQHAKNEGKVVRRMPELMQKEPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IB45</accession>
    <name>A0A1B9IB45_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_00062</name>
        <name evidence="2" type="ORF">I206_101260</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF52766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013985.1">
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    </dbReference>
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    <dbReference type="KEGG" id="kpin:30168431"/>
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    <dbReference type="Pfam" id="PF12586">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCF52766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC67352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="474" mass="53832" checksum="222B1A1A279D744D" modified="2016-11-02" version="1">MATLPTSSMYALLMMKKYGDLPLIDSRDTPRTLSGGGAPRSAADCCFSEQAVNPASLPDHPHLHLTRQIRFAFASRPAMLQVQNDASDGSHSILSSPTHNITSLDRLLPLQDHIFHYLQTDHPCSVLRLNRSFYTDYLPIVYRKVEVTGDGLCKLLGSLIRLEIDPIRKGRSPVYGERVIKALKYVEQLDILDMGNGEKVDETLRLWTLYKMDLIFPRLTHMSIGKRVITPILNPSLDPASLTGFLGLDVLIHLIAFSSTKTLCLDWPITEITSNDYGERDGSKLDCFIPELLKNLDQSITQLELVKVHVKYDNLGKMIFNILEHRSPWATQHPRPKIILELTNESNQSTVAILGELCGTVLCTMDELFENELHFDSTMIGNDITFILPDYKDRQAAIDEIMEEEVLDDYEGMWYTVLSNIVWKHNDNPKEWDCPCGKFPVRNIPDDTLIEDGLDSEQEDPTQTKIDQYFKHLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IB56</accession>
    <name>A0A1B9IB56_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Btz domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I206_00075</name>
        <name evidence="16" type="ORF">I206_101247</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CASC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF52779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC67339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013998.1">
        <property type="nucleotide sequence ID" value="XM_019151860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IB56"/>
    <dbReference type="STRING" id="1296096.A0A1B9IB56"/>
    <dbReference type="GeneID" id="30168444"/>
    <dbReference type="KEGG" id="kpin:30168444"/>
    <dbReference type="OrthoDB" id="2565173at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
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    <name>A0A1B9IB62_9TREE</name>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 10737</strain>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
        </source>
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    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">CBS 10737</strain>
        </source>
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    </evidence>
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</entry>
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    <accession>A0A1B9IBU7</accession>
    <name>A0A1B9IBU7_9TREE</name>
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    </gene>
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        </lineage>
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    <reference evidence="3" key="1">
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            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
        </source>
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    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">CBS 10737</strain>
        </source>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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    </evidence>
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</entry>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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            <strain evidence="2">CBS 10737</strain>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="OCF53206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="WWC66913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019152287.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A1B9ICF9"/>
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    <dbReference type="KEGG" id="kpin:30168876"/>
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            <begin position="1"/>
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        <location>
            <begin position="405"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF53206.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="537" mass="57022" checksum="FFA26377A97EB996" modified="2016-11-02" version="1">MSITMTAPSAHSETMERSISRPSLTHSSSSTIEDSQNSQLHLNQVASSNEDTETLITPIEPPLLHVSIKNGSSPIKIEATIDEEIEHNSPVKQAKKGRLNLSKSMQTLRKKGEKGRERASSVGEKTTPPVPAIPAITEKKTISQPKTNVFAPSRPPMPTKQSSGFASFLRKLTGRSSTTPAPSSTPYEKPAIKDDKSATLAKRKTMAVAGNSKPSLPRIDTSKVEGVPASATSKAGQPSSAKQFVQSPVPVTPSIPLVRESDPLKIPLPPSPMLEQPPTLPPGAAPAADFSTSTASQIGSSQQSTVTRKKAEAMLSLEGFEFEEEEESKSIPELAPVISATPVSPEKDHIESTDVVKPLAPIRIPSRTTTNGPASASSVRSSVFSSSAETRIATPLSATSVVAPQLKTASTSPQNQNQGLSPEKIYEGMKLAGSSPPRKAPVGTGLGDLGRKESKWRKSVMGLSDKAKPVAKRQSAMPPPTSYDAYQAQQARIARNRQSCAPTLHSSASIAAAARGQMNNMNLSKDEQDMAETFFMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9ID44</accession>
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        <recommendedName>
            <fullName evidence="3">Protein CPL1-like domain-containing protein</fullName>
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    <gene>
        <name evidence="4" type="ORF">I206_00874</name>
        <name evidence="5" type="ORF">I206_100455</name>
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    <organism evidence="4">
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        <lineage>
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    </organism>
    <reference evidence="4" key="1">
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            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014788.1">
        <property type="nucleotide sequence ID" value="XM_019152650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9ID44"/>
    <dbReference type="STRING" id="1296096.A0A1B9ID44"/>
    <dbReference type="GeneID" id="30169243"/>
    <dbReference type="KEGG" id="kpin:30169243"/>
    <dbReference type="OrthoDB" id="439917at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048661">
        <property type="entry name" value="CPL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038955">
        <property type="entry name" value="PriA/CPL1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192:SF2">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21671">
        <property type="entry name" value="CPL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628524" description="Protein CPL1-like domain-containing protein" evidence="2">
        <location>
            <begin position="32"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Protein CPL1-like" evidence="3">
        <location>
            <begin position="107"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF53569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC66552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IDK9</accession>
    <name>A0A1B9IDK9_9TREE</name>
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        <recommendedName>
            <fullName evidence="13">Non-structural maintenance of chromosomes element 1 homolog</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I206_00809</name>
        <name evidence="16" type="ORF">I206_100518</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the Smc5-Smc6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the NSE1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="13"/>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014723.1">
        <property type="nucleotide sequence ID" value="XM_019152585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IDK9"/>
    <dbReference type="STRING" id="1296096.A0A1B9IDK9"/>
    <dbReference type="GeneID" id="30169178"/>
    <dbReference type="KEGG" id="kpin:30169178"/>
    <dbReference type="OrthoDB" id="185455at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000270">
        <property type="entry name" value="Non-structural maintenance of chromosomes element 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011513">
        <property type="entry name" value="Nse1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973">
        <property type="entry name" value="NON-SMC ELEMENT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07574">
        <property type="entry name" value="SMC_Nse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 13" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 13" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="265"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="290"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="335"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCF53504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="WWC66615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="358" mass="40763" checksum="F9646E20F3069B68" modified="2016-11-02" version="1">MTQPRHANSTNLHRLFIQSMLSRRALKEDIALELYKRAVGACQAYDDTFRPLHETTLRGFRTFLSDVSDIMHDLGMEVITGQEQTGKGKSWVILRNIDPSEVALQATDYTPLEIDYCRRVVKEIIESYPANSVSHGQALTIISELDGQMTKHAGEALLNSFCSRGWLSKSKRGRYTLGVRAAVELEPYLKQQFEDYIQNCKQCKRLMLDGVCCSTDGCESHFHSYCYNSIQKLPRPTCPECKNRFSEKEPTPIGEKSVSKADDDFINLKKRKRPSTKGKSRSQTLRNADETDEEDEDELEDEEGVEGSGFIEKAGPSGWKVDSTSRRRSVVPETQFDEDEEQEEEDDAPVNRRKSGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IE25</accession>
    <name>A0A1B9IE25_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_01196</name>
        <name evidence="5" type="ORF">I206_100131</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019015108.1">
        <property type="nucleotide sequence ID" value="XM_019152970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IE25"/>
    <dbReference type="GeneID" id="30169565"/>
    <dbReference type="KEGG" id="kpin:30169565"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN DAL81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="209"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="295"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="407"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="308"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF53889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC66230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1014" mass="114706" checksum="CA6BED3F2ADCA8E2" modified="2016-11-02" version="1">MSITPIKSQSASTNGSIDIPRNSLFTHSPSMNTLHSSPVTYAILPNPAHHTPHQSHLALPQQPVPARSDSFPQWHANPPPRYHYKQTSDQRPMTRATNTLPDSAYAYTKGSTDIRHDMITSERQTHQPSGTSGSQTSQKKRPREISTHHILPVDHDARDNFWDHKPLSPDQTGSFDHRTHSNSHSHSPKPTTITISVPAVLTRDKKQKACANCRKAKLKCILEHGSTECIRCKSRKEKCTFFPRSHDEEVQQRLIKDMYEATTHLAQLSKAVQHILQHLTQKNLIPPFVSDDHPDGLDTYIPPNQHMVSKDDNEHSGKLYNEADKADNKPDRKPKARKIDTSDNDEKDEFKEHRLLMNNGSPGEISRESRSFDSQSSYQPRPSLDDPVQTYSDVMIRPPPTTIYSSPLPFAAMLPSPHPQPTSIPPNRPSRSPPPLLASPDKQVHPSIGQVLNSANIGWNIGRPPIAEVSSRPLSRSRMSSPPMMSSTPDIIHQGQHRFNQTVDSTKHYMSHESTQTLPDEREQETIGSQDPRKDIVKKGLVSPQDAMTLVNYFHESLSPLMYGYTLSFHQFPYISGPAYISPLLLSVLCLISSERMSSEFENRYHSILAQEVTNLLQTSPAESWQRFEGIYTPDFGDPDGDDPLDAEFGLGPEEIVASCILATYMVQREQASVIARSAFRWARGWIRLLQSSSVPRFTIAESVGLVPPERKATNADMARIWLLCYIVDSTERLQLLLDAPPARDAISWCSVLIPPTNMDQQLPYSKDIPYHKPDILLTFHARLITILNDWRTQFKVLISASQPSDQLVEEIKDLSSNINERLGWWKSEFENLIYSPLIDHTAAISIYGPSSIIGYGQSNQHIMITFHFIRSSVNATLTKYLPLNRTQNGYRPESNSPFIEKQQADYRLRIESKKSIIESSIEFFKICHSWFSTPNMSPTYLYFVTFMGSEMVDAIEEVRKNGKLSETVMIHTIIPLLHSVGETLLRGDLNENHVSKITGKALFSYCEKLQKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IEB2</accession>
    <name>A0A1B9IEB2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_01071</name>
        <name evidence="3" type="ORF">I206_100254</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014983.1">
        <property type="nucleotide sequence ID" value="XM_019152845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IEB2"/>
    <dbReference type="GeneID" id="30169440"/>
    <dbReference type="KEGG" id="kpin:30169440"/>
    <dbReference type="OrthoDB" id="2564766at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="762"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="553"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="762"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF53764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC66353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="863" mass="93422" checksum="CCD003C6DB9F0D41" modified="2016-11-02" version="1">MYIANHHPYQNQHFNFNPSQESLGNSLFSEEAQQLPSLQVTHPTPTKAMKFRRKSTDALSVSTVSSLDPSPIGQMQLLPSPGSGTLDVMLEAISVPGMPRSRPRSPEIDLDDDDSEAERVRMEERQARIREKGRERQRRKRERDKKAKEAKSSAQTSEHLPVPSSSQSKNIAQSLSISVPSSYVVGPPSSTSVASSLPQSASYFPTSSSNFVFGFPTGSTSVSGSSTPMTLFSPSASTPGLGYSPDTSMSASLFSLGLEGTMPSATLELPADRAGKKNNRSKCRAGSSSGTSRKVSPTPLLTDLPQPPRETQHPVTKSAKRRKSAPQTDALISMSALSTTDGHVGFQESAPQSAPPQQAKPIEGSRPQPRRTASDGIVMRSSWDKERDWGARSPTPPPVPTLPTEFRQVQRPQTSLSVDAATDATLASSAQAEVFASRLVHLLNKDDAESGWLSNQIGLDGKDLDSLESALRLTYEKWILEKGMKEMSIDPSDRFFNSRSSSDSIASSTTCMTRTTVPNSPVINTSTPMSPAGFFTPLPSRTSSRRGEKRSTVVSPIPESPSASESVTHTRQRSLSSASMKARGLHITSVMPSQQWSHPTTPNLSQEAITHLPTDHQKSDDTASPVNSSLQTPSTGQGSFPVSAQMTNYHGHWRSATEPTGQRIYTTFQQPPETPVRPTTGETSSMWQVPNTCPPQHVHHVLESPLSMTVNKITGQMEMPPPPLSSHTANGMTSIGIFENQNVTSSLGASEDQRHFSTPISVRSQLQSGRNTTAVPFTPDTPVPVRGQNHSTFENGLINSMPMWYNSSFMAQHPNGGHQHVQVLQSPIAERGHRAAHHEAMIHNADLGYNGSGQPGFGAHQQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IEC2</accession>
    <name>A0A1B9IEC2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_01209</name>
        <name evidence="3" type="ORF">I206_100118</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019015121.1">
        <property type="nucleotide sequence ID" value="XM_019152983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IEC2"/>
    <dbReference type="GeneID" id="30169578"/>
    <dbReference type="KEGG" id="kpin:30169578"/>
    <dbReference type="OrthoDB" id="2574480at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="644"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="751"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF53902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC66217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="774" mass="84375" checksum="B0B454673B6E7686" modified="2016-11-02" version="1">MSDSPRRPSPLPSSSDLPPPDYAPSQPQILITPLPDSASFFWGKTVQGEIYVKGLGEGRGNRVDIVKSLSVQLTLTNHLPQHPIIPLHTFQLQTLYPPASTSNSSSSTRSDIVVPFSTCHRFSISLPASLPNQTEHPLPGTLNLTSYEKGEIRYALEVKLILPNDQVVVEDMKIEGTPQQIYQTLSQESGSPRQTDSEVEERLEKNGVLARLLMDKDRPRLGELLRLGLEIRPVERKKGTAVFDLAKQSDPTETLRPLRRVRVELFRKVTIHPFSSGNASSSSSSTAISSTEHLTLLHATGKSLRYPGTGKKYPPLRVLFTIPTAQLGVVAEQTWGEISCTTPYHTISFFIKVTIGFGDISASRDWTLSREITIKPKKWKEPREVVIERGLQPDLGSPTSLPLEPDAGRSGSSEDLELPRNDRQDSWSEDDYRKEAYRQKGEDVVGNTGTYRLADNDSPPPFLETEGQAGPSRSGGSGGQQSELPSFLESEEQARTGEIPTLKETVRTERLVPVNFNVDQVLIPSDNDTLGETREAEEAEDRSNWVGRRGSLGGELGTWVEYDGYETFSVAPPSMAASYGANGPMDPPQEGDENNANLVGGIVARLGLDGDGVDGVRMQGLELMEHLGLGEGTRVVDLQDDLPPGIDEPSLPALPDFQSHHHQHVQDELIPSSPPPPAHAPYISPSNHSHNLPPVHDPPSFDASQAANAVGGVATSHIRSLNSTNVNSISMGSVRRPSRNVIDDEVVEQVVTSQGDAPPGYERAGEQGLPPSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8KWR3</accession>
    <name>A0AAJ8KWR3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zinc finger CHCC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_100135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019015104.2">
        <property type="nucleotide sequence ID" value="XM_019152966.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8KWR3"/>
    <dbReference type="GeneID" id="30169561"/>
    <dbReference type="KEGG" id="kpin:30169561"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.40:FF:000003">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.40">
        <property type="entry name" value="q5lls5 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019401">
        <property type="entry name" value="Znf_CHCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-A SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10276">
        <property type="entry name" value="zf-CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc finger CHCC-type" evidence="2">
        <location>
            <begin position="97"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC66234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="140" mass="15280" checksum="351ECE289946FB0C" modified="2024-07-24" version="1">MSVLRSVRILPRNVSAIRTYASIPQPSDPVPSKQPSSSSPPTLQQSPNIPTTWSTGQNPKPHAYDNQRFEQTALQFQPNPQSAMGMVNKDPVRLVNGRRAVCDGGMGALGHPKVYINLDKPGPKVCGYCGIKFEQAHHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8KZY4</accession>
    <name>A0AAJ8KZY4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I206_100880</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058389.1">
        <property type="nucleotide sequence ID" value="XM_070202288.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30168815"/>
    <dbReference type="KEGG" id="kpin:30168815"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016242">
        <property type="term" value="P:negative regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009076">
        <property type="entry name" value="FRB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF9">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08771">
        <property type="entry name" value="FRB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01345">
        <property type="entry name" value="Rapamycin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="11">
        <location>
            <begin position="394"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="10">
        <location>
            <begin position="1038"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="12">
        <location>
            <begin position="1444"/>
            <end position="1477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="129"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1150"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1344"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1150"/>
            <end position="1167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
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            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC66973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1477" mass="167404" checksum="6D2AA6BB75FD2F7A" modified="2024-07-24" version="1">MSGNSQYRITHRMVPLICQALIAAPDDETVWLEGLRMLANPKLKQALTLTSSIWLSLLLRGLEITKPVAVINSALNLLTHVSEILEPMKSCLLKPLRALGREKQFENMVEFINVVEKLDLTVWNSEKKPIGRPQSARTAPNSQATTPLPSGSDQAPAQKEQHPLLAEILIHNLPPKSRTVQQAWSQTLFSSAHDNPKIWLHNLYQATLEASNVPELVIASKLGHLIHEELFQTAFMHCYVQLEADASFKNVVDNTLMLLLNDPSISQDITIVILELIAFFNKDKREFLPGVHKAAKNCALNHFDGALNSPLPGIVLWYVEQNAESFPIQENIANLVETNIRVGSAGYDAAWSTLLWLERDWKVEAEPIWITQLSHWQQALDAQNKLDHNQEGTTFSSFNTKMICYHALGCYQQGYELAQNLFEGLDDLERRNTAHWATAAAWHMGDFETMADYLAFHPKGTSKSLYKAIIDVHNGQYASAFHHISKAQSLSYDEVQVQLNVGPQLAHRSLAKTELLVELQEVIQYKSQPELRENLISTWKTRFKKSHADPNTWLKRLELWTLACPPTTTGLQSCFIDCAKLCESAGMHQAAENILRKITPSITPLGCKVEYTRFRFEWKSAYQHHDQHKMCQVLDRLIKHTQAYMKDIGVDQAELERQGLGLQPLTVLSGCDPTHHHTLSRRYFRIAEWTAALQGDDWITDETSQVLNYTSLASKIDNNWYAACFSLAERSLAIFETNEFSRSDNMAVSSYIVPALRGLFQSARTKENPEFVIKALLRLVTLWFRFGENIAVLVEVENQLSLTSVAPWLSTIPQLIARLGTPNKELQHTLINLLKSISSQYPHAVIWPLLTATQTSKSEHQEAARAITNFICTMPDGIRLVDQAELVGRELIRVSASLMEKWRSIIEKIIPRTDLMDCPWHEVPSIWEHDMLYLKAPETPDDEQFVQVFGDQLFQVDKALRRYKNNRQISIVNFAYQELYKLYGDLEAQINQWKQPGSKLHLADTAPRLLSIRDCVLTVPGQYDPNMKLDDQAFIDSFSPIVDILSSKMLPRKLVIRSYTTDYTFLLKGNEDLRGDERIMQLFNLINTMLSHNSDAFSRNLHLLPYEVIPLSPSAGLVSWVSNTQQLQSMIMFNRAKNYQQDLNDKETASLLGHDPKTWNPKRENPRFDPPAEMDRYDKLPIPTKVERLKACLAHSKQSDLKDVLWQKSPSSDIWIRRRTNFARTVGVSSFVGYIIGLGDRHGSNILIDQLTWGALHIDFGDLFNVAQERSFLPEKVPFRLTRMMTNAFELASRGGLDVPGTRGTFKQASLIVMNVLRDSRSTVLAMLEAFLYDPLLSWTIGPNDPSNAEHGGSAQTSSESKPKKGKKPPVQTHIVPQSLAPQGIQGGSDLYDRIENSLITTYLENDSYMAKVSSGTEMTNSKALQVLSQIEKKLVGYHKDTARPLTINRQVQALIEEATDLENLSQGYVLGWIPQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L0I7</accession>
    <name>A0AAJ8L0I7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_100862</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058386.1">
        <property type="nucleotide sequence ID" value="XM_070202285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L0I7"/>
    <dbReference type="GeneID" id="30168833"/>
    <dbReference type="KEGG" id="kpin:30168833"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055236">
        <property type="entry name" value="EVH1_PP4R3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006887">
        <property type="entry name" value="P4R3-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051137">
        <property type="entry name" value="PP4R3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318">
        <property type="entry name" value="ATP SYNTHASE GAMMA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22972">
        <property type="entry name" value="EVH1_PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04802">
        <property type="entry name" value="PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PP4R3 EVH1-like" evidence="5">
        <location>
            <begin position="128"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central" evidence="4">
        <location>
            <begin position="298"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="23"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="802"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="830"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="845"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="862"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="882"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="930"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="989"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1001"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1013"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="1049"/>
            <end position="1063"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC66955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1063" mass="118733" checksum="9EA54CC8EDEA9AF8" modified="2024-07-24" version="1">MTALHPTESSINLLSSDERTLVEAESSKSATRQPKAIFVKGNTDMVEAEIDSKDPSTSLSSTSPQVNEDGNDEIDVIGMERDDVDMVENRQQDGGIEDEGGGGEGIGDDGNGDIDDLGNEMDPNSDGKRVKVYELQDTSWHDRGTGFCKGIYDDTQDIALIIVEREDFSSEGGKAEAPGGFLKEELLLSARVEKEDIYGKQQDTLIVWTEPATGLDMALSFQDPEGCEDIWQFICEVQRHLLNVPSSEVETTQIPSSSSPAHNSPVIGPGALAMQVSDSRVPWQTPTLANIRDQEMFIRMQAKSPIGREKAVEHILNEEYIKHLITVLDQAEDLESLDDLHALCSLMQTIILFNDNGVFEYILQDDVFMGVMGMLEYDPEFPGLKASYRQYFQDTARFRQVVEIKDDNIRNKIHQTYRLLYLKDVVLARVLDDPTFNILNGFVFFNQVDIINYIQQNDMFLSHLFNGFHEPPPDPEVSKSEPLDERKRDVVMFLHQLMTMGKGVQLAGRLTLYRNLVERGLLFVCEWSFRRTEAQLLHAGAEIMTLAVEHDANVVRLHVFKEDEAKRRTLIMEIISLLQSTKNLGLMSQMSDTLRTLLETPPDNEAFVPRTKEGPLSESFSTYFYENCANLLYKPLLDAPDVKAELNKNPKFKLTREHITLLQHLVELLSFCVINHAHKASYFVLSNPISKKIVNLLYIKDKPLRHAALRYIRACLKTSNHFMHRYYVKNDLFLPLIELLEEESVRDNMMSSACMDVLELIRRENLKTIINHLFDSYRERIDKLSSRAFLRKYIAGLRNRWEINNEPPPSIPQSSAVEAEPSKANADRNAEEEDYFNGSDDEETASSGDITKAQQNVEIPSKRKRMYTHGGGPKKRPAGARSPNMSTSSNSPSSNLETSTSTSGSGSGTGGALGLDYDDGSDSDSSSTGQRSPRNSSSDKIPNSNLGNLNLTKEELEDDLGDVAMRMRAKRQREEEEEEGFAGLLVGAKTTTTPTTTITTTKEENKEEDKSINDNNIISKSRINSNNTGNSTPVKDMGKKIRLNLGFGKKLGGGGGGGGGGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L0P9</accession>
    <name>A0AAJ8L0P9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">DNA polymerase</fullName>
            <ecNumber evidence="20">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">I206_100767</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 20">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="20"/>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014478.2">
        <property type="nucleotide sequence ID" value="XM_019152340.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L0P9"/>
    <dbReference type="GeneID" id="30168929"/>
    <dbReference type="KEGG" id="kpin:30168929"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05777">
        <property type="entry name" value="DNA_polB_delta_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05533">
        <property type="entry name" value="POLBc_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000004">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050240">
        <property type="entry name" value="DNA_pol_type-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025687">
        <property type="entry name" value="Znf-C4pol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322">
        <property type="entry name" value="DNA POLYMERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322:SF23">
        <property type="entry name" value="DNA POLYMERASE DELTA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14260">
        <property type="entry name" value="zf-C4pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 20" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 20" id="KW-0235">DNA replication</keyword>
    <keyword evidence="17 20" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14 20" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15 20" id="KW-0408">Iron</keyword>
    <keyword evidence="16 20" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6 20" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 20" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 20" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="22">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="21">
        <location>
            <begin position="288"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="domain" description="C4-type zinc-finger of DNA polymerase delta" evidence="23">
        <location>
            <begin position="756"/>
            <end position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF14260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="WWC66860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="851" mass="96021" checksum="EC345D54F571BB99" modified="2024-07-24" version="1">MIDTKVVGMNWVEIPGGKYELLEGKDKKSRCQIEVSLDYKDLISHAPDGDWLKIAPLRVLSFDIECAGRKGIFPEAQIDPVIQIAAMVTRQGETKPFIRNVFTLNTCAHIVGSQVLEFKDERQLLLEWRGFMETVDPDMLIGYNIVNFDLPYLLDRAKALKVPDFAYLGRLLGVRSEIKETHFSSKAYGQRDSKAVNIDGRLQLDILQVMQRDYKLRSYTLNAVCAQFLGEQKEDVHHSIITELQNGTADSRRRLAVYCLKDAYLPQRLMDKLMCFVNYTEMARVTGVPFNYLLSRGQQIKVISQLYRNAGEAGYIIPALKSEGSDEQYEGATVIEPTKGYYDVPIATLDFASLYPSIMMAHNLCYTTLLDKNTIERLKLVEGQDYVHTPNNDYFATTNKRKGLLPTILQNLLGARKKAKQDLKVEKDPFKRAVLDGRQLALKISANSVYGFTGATVGKLPCLAISSSTTAYGRQMIEATKQEVESQYCITNGYEHDAKVIYGDTDSVMVKFGCPDLATAMRLGAEAADLVSSKFIKPIKLEFEKVYFPYLLISKKRYAGLYWTKPEKYDKMDTKGIETVRRDNCRLVSTVIETCLFKMLIDRDVKGAEEYVKQTISDLLQNKVDMSQLVITKALAKADYAAKQAHVELAERMRKRDAGSAPSLGDRVAYVIIKGVKGAAAYEKSEDPLYVLEHNVPIDTRYYLENQLSKPLMRIFEPILGEKANSLLAGDHTRTIQIATPTIGGLMKFAVKTVTCLGCKTPLRSNKDGAVCVNCRPKLPELYQKQVVQTSALQIDFARLWTQCQRCQGSLHQDVICTSADCPIFYRRTARQKEVAAAVTQLDRFEKEAFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L2R9</accession>
    <name>A0AAJ8L2R9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_102184</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC68261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058622.1">
        <property type="nucleotide sequence ID" value="XM_070202521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L2R9"/>
    <dbReference type="GeneID" id="30175092"/>
    <dbReference type="KEGG" id="kpin:30175092"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="75"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="221"/>
            <end position="224"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC68261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="541" mass="59898" checksum="1B4C31C9E330E84C" modified="2024-07-24" version="1">MTWQDTAAQYRAERDKLFPKEWLLEVPPSDDVLDVREIPTLPGILSELELEITETLTVTELLEAIKNGEYTSLQVAQAFCHRATIAHQLTNCLTEVFFDKAFARAKELDGYYAKTGKTVVPISLKDQIEVEDTNTTMSYVGWIGRKAKHTAVIAELLASQGAVFYCRTNMSQGLWFGEGYNNVFGRTTNPFNRDVTCGGSSGGEGALIGLRGSLLGVGSDIGGSVRIPAAYQALYGVRGSYARIPYCKASNSCEGQEMVRSVLGPLTVSIDGLKTFYKALLDAKPWEFDPWTPRMPWSETAYNLVDHGEGNKLCFAIMWDDGVVKPCPPYVRAMKELKEALLAAGHEVVDWTPYKTAESVALLSRFFTADGGYDLKKQLDLSGEPQLGGILDRTATELSAHELFDLCYRRSAFVKDSLDHWNATVNQTSTGRPVDAIIAPAGGTPPQPHDGYMYIGYTGFCNLTDYTASILPVAFVNPEIDSKPARDDYLSEADQKIYEQYDPQFMKGAPCSLQIIGKKYEEEAIIRMTEIADAALKKYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L2S7</accession>
    <name>A0AAJ8L2S7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Signal recognition particle subunit SRP72</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_103476</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SRP72 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013453.2">
        <property type="nucleotide sequence ID" value="XM_019153292.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L2S7"/>
    <dbReference type="GeneID" id="30169889"/>
    <dbReference type="KEGG" id="kpin:30169889"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013699">
        <property type="entry name" value="Signal_recog_part_SRP72_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026270">
        <property type="entry name" value="SRP72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031545">
        <property type="entry name" value="SRP72_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094:SF9">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08492">
        <property type="entry name" value="SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17004">
        <property type="entry name" value="SRP_TPR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="Signal recognition particle SRP72 subunit RNA-binding" evidence="10">
        <location>
            <begin position="211"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="216"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC69534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="306" mass="33450" checksum="46DCEAFEDE1F1276" modified="2024-07-24" version="1">MSSTKTATTGSKRTFTPRPPRSIEERLPKLYRALTDQVDDGYYANAIRTCKKILSLDPASQAAYQTLLFLHLQTDDYNSALSLLDTPPKDAETLEFERAYCLYRLHREKEALGLISGKDGRKVNHLEAQIRYRLGEYQKAQEIYDDLLADVGSSSSEHSDILTNLNATSSHHTFATSTYRSHLPSTSNDLESNVPSLPTGWSSGGLAKVVEKKTAAAKPSIEKKVAGEKKRKHKLPKGAVEGKNVNQDPERWLPLRQRASYIAAQHKKKGGKESMGTGFTQGSTAQASGNSGGGGGGNKGKKGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L472</accession>
    <name>A0AAJ8L472_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_103044</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="WWC69108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058773.1">
        <property type="nucleotide sequence ID" value="XM_070202672.1"/>
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    <dbReference type="GeneID" id="30170321"/>
    <dbReference type="KEGG" id="kpin:30170321"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TF_fung"/>
    </dbReference>
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        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF20">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Zn_clus"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
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        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="647" mass="72037" checksum="91493DCA554334C5" modified="2024-07-24" version="1">MPKIPTEKLSPDSRRESINAPLSVTCVRCRAKKVKCDSNKPTCLNCAKDPSECFYPPKLKPGLRPGTGLEMIKRVELLEERIETYEARLAEQESRLAQIRQAGPSAGPSFSYDTQTPLNDHFLPNAQTNTFNPLIQTSIAPSQTQLNSLPSNLSNPSVQSLPFVADPSPTSGFDPSSLAISTSPGVNMASPASFLDPHILPSDDIVRDLLSLFFTHIHPWAPILSPNMPEFKPPWTIVHHAIVVVTLRLSTDPRLNSTKDLIKKRAKQHVLAHAVESTSISSVQALALLALDLIGSEQGPSSWGILALLTRSAVHLGLSKEEEAPSWASIAPIPALSRTVIIPPATTWHEDESRRRLFWLIFCLDRYACVATGWDFALPDSDIKRRLPCSDAVWARSDWHQSPPFRSIFQRETLYFDLDDVSPMAYLVEALDLLGRAHTLQSQMLEPGDSRAMNNRKDKTLALTASTKRWFANAPLERIEPPGMRLMIQAAYYAARALGWMTTSSPVFIWGCWVAARVIFVHSFLNHQTQPDENFNTILAALKEQSVYWSLANQYVKLLERAKRKWQNSLAGGTTTSSLPDAIHVLLDFHRTAYSAVHQNQLQETPHVTPPEHDLAHLPVWAVQPGLGDLYSWFDLPAGLFQADTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L4G0</accession>
    <name>A0AAJ8L4G0_9TREE</name>
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        <recommendedName>
            <fullName evidence="2">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_103314</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="WWC69375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_070202721.1"/>
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    <dbReference type="KEGG" id="kpin:30170049"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
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        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="Papain-like_cys_pep_sf"/>
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        <property type="entry name" value="Peptidase_C19_UCH"/>
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    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
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    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
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        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF39">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="54"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="532"/>
        </location>
    </feature>
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        <location>
            <begin position="631"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="945"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="403"/>
        </location>
    </feature>
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        <location>
            <begin position="421"/>
            <end position="439"/>
        </location>
    </feature>
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        <location>
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            <end position="456"/>
        </location>
    </feature>
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        <location>
            <begin position="498"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="667"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="699"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="737"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="765"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="802"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="945"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="965"/>
            <end position="986"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC69375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1029" mass="113051" checksum="036F915C9E6256E8" modified="2024-07-24" version="1">MTVSTQQSQTTDLGMDNSTDHDNSAASSSKTASSPRIEQKYSITAGPGMELKPIGIHNESNTCFLNSTFQALSATAPLTTLLASSPQSPLVINPESSLPFAIVPPKLIPSLQPDILEPPLYDLLPVTRAFTNSLHRAWRMKEAGGGTYGQGETSSKRSMSLNSLLREIARKYDQYDDYSQQDAHELLRHLLDSMEMEEKDVIKKLQPNLTPLNQNGIYKRRRKSKQNETIRSGTTTPGATNYNGTTLTQQHLMDLKHISPLPSPLPSPAQTRPPSPGHKDVDPMTSDVPLNLNGQMTGHAFKEDQIFSPSETPTDVGSEVIQTIPQEKRMIPFVDVLFGGSLASVVVCERCKAVSHTYEGFLDISLSLKGDDPKPRKRDRLRAMARKFRPRKSSSTQNAQSPDVQHGGSSVVSDSELSESEIPREKDRRKSMDSDDRIMIDSNHTNSSSGLGRSGSTRAFSGLKAKPSFSFGRKKDKKAASPVIAPSSIMEGEEDRTPPTSTPVSPSLHSQDLHHKKSHHHKAIHGPGPTPAQAAYISRILAPPPGTVDLDDPIARLRAAQSGQSIETTNNSSSEYGLVDALKAFTSVEVLEGENAFACKKCWKIKHGYYAKHEATVKEEDEEQLAAALTEDGFGLPHTSTRGSVSSNVTTSSTGTSPMMISNPQISVMGSGSPSSEKSNNSSYYDASSLPDNRHGRSQRYTSTNSKQAIARAPSPLRRNIKPDEETDDLNERLASTKLSSTYGSESALTTDSGLTSNTSVSNDDLIEEDDAQDAEHDNEEESDGLSDSETSVDEHNDAHKPKSKNSKKSKNTSHVVMGRAFKRYLIAKKPEIMVFHFKRFKQTAKSYSFSSFYDLKKIDDFVSFPENLDLAPFLAPNRQDYKVHQTSNGPKATYMEWANPEQGPELEPVMYRLYALVVHLGTMIGGHYIAYCLVDPEKMFGLNKDNEENKTPTIEPRDSKSPGIGNSNASLKSQQSGLSGMSGIENNKNIKEDKRVWCFCSDTSIRLASIEEVLSQKAYLCFYEKVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L4R4</accession>
    <name>A0AAJ8L4R4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Leucine carboxyl methyltransferase 1</fullName>
            <ecNumber evidence="3 8">2.1.1.233</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_103081</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine = [phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:48544"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="2.1.1.233"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the methyltransferase superfamily. LCMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.233" evidence="3 8"/>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058776.1">
        <property type="nucleotide sequence ID" value="XM_070202675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L4R4"/>
    <dbReference type="GeneID" id="30170284"/>
    <dbReference type="KEGG" id="kpin:30170284"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018423">
        <property type="term" value="F:protein C-terminal leucine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016651">
        <property type="entry name" value="LCMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600:SF21">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016305">
        <property type="entry name" value="LCM_mtfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="201"/>
            <end position="202"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR016305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR016305-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC69145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="382" mass="42910" checksum="77FF27FE1C673DE4" modified="2024-07-24" version="1">MLPPRIPPNNPIQVQKNGMIHPDDAIRQTDDDASSSRASAISLGYLEDPFSKLLYKSNLSIPNSGISNNRKPPLINIGTHHRTIGLDKIINEFLNSGNKNEKKQIVSLGAGSDTRFWRLMSQSNSTKISKYVEIDFPHLTSPKAQRISRFKSLQFALSSNSSYIEYENENENSSNSINKIFEISKGGTKLNSELYTLLPIDLRTSSSSSSSSTSTKTTTIKEILSEELLPILNFNLPTLFLAECLFPYLNPKESENIISWFGENFNKCLGLIYEMIGINDSFGKVMKRNLSSRNLSLPGSEPFPTPKSQADRFLNSNLGKGVFTSSQVKTLWQIREEIIDQEELQRISKLEILDEIEELKLVLEHYVIAWGVKGECLQNVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L4V6</accession>
    <name>A0AAJ8L4V6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_104580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012619.2">
        <property type="nucleotide sequence ID" value="XM_019153879.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L4V6"/>
    <dbReference type="GeneID" id="30170483"/>
    <dbReference type="KEGG" id="kpin:30170483"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WWC70629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="160" mass="18215" checksum="81B695CBB1ADD898" modified="2024-07-24" version="1">MSSNDQAQENAAKQEQVFWILPQNIQPIQVIPDRYTKSNEVSSENMKGKESDPSRMGVFVCLLDNKPHLHPSLQALHKHRLIIHKIPLPADPINDLPVSQSNISNITNPFIGQIEQDIIMSSTSDLPQESVASIPNKTEWFMWKFSEEEANRRKSYLPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L521</accession>
    <name>A0AAJ8L521_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_103676</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013258.2">
        <property type="nucleotide sequence ID" value="XM_019153097.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L521"/>
    <dbReference type="GeneID" id="30169692"/>
    <dbReference type="KEGG" id="kpin:30169692"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WWC69733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="193" mass="22780" checksum="6B697BFD0F3DAEC0" modified="2024-07-24" version="1">MSMSPAARFAGNAVIIDNLYDHLDQTNTLVMMKVKKTFYEIGLSHLYEEITIKIGKPDPFANIELDSNVRNSFEDEKIQKPNINMIKRINFFYHTKSQCPFNIYRNIPILPNLKIINLLRGEIPNSIEYEKELCEYSKCQFLKESCINIKKIIIYQLNFKVLKNFNKLEEIIIKIRPCQAPNIKRFMNKKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L534</accession>
    <name>A0AAJ8L534_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_104284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010836.2">
        <property type="nucleotide sequence ID" value="XM_019155878.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L534"/>
    <dbReference type="GeneID" id="30172508"/>
    <dbReference type="KEGG" id="kpin:30172508"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WWC70334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="454" mass="52136" checksum="C71DFC56C0D733A8" modified="2024-07-24" version="1">MEHNGNKMEDRMNINNPFHNLSSGIPQGRPKWAYVFKIKHDFNLPNEIIDIIASFSNNATLSTLMRVSKSIYDIASKRLYQHLTITKKNAEGIFLGLPRSAYHSPHRSSNTQSRSTSKSTAALQLYWPDVPLDSENDEECGDDVDYVDASRKDHQDQPSVYLASKDSVRRKINLFRFVTTLKIDCRLPTRLMQDLFGWIGQQPSGHRTIFPNAKKLIITGEAIKQWADKRDRSHPFCRNRCPTSIEPDVLFLNLLKIIAFPDSICISFPKYEEKDFRRYMNSRSRSVQKALGRGTTLGAETGLTSSYDKMAKFAQNFVVDLFIPTLRKSCKITLHNHTRIRLPCEIRVRELRVFISRSARHSNVRALNHAGDIDKETCTKQLQRLADEILWAYDTSYTLVIICPSEPPTPAQWNKILHTAKKELYFKPDQRRVPLNRGEEYVMIVSSSSGIVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L667</accession>
    <name>A0AAJ8L667_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylinositol glycan, class U</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_104075</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGU family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058981.1">
        <property type="nucleotide sequence ID" value="XM_070202880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L667"/>
    <dbReference type="GeneID" id="30172718"/>
    <dbReference type="KEGG" id="kpin:30172718"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009600">
        <property type="entry name" value="PIG-U"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN ANCHOR BIOSYNTHESIS CLASS U PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06728">
        <property type="entry name" value="PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC70128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="53116" checksum="8032F14BBA8C89B1" modified="2024-07-24" version="1">MLSSSRHDYFPVPVLYLAFFQSPTKPHPRDEILPVMDLATIRTSLKSPQGVLCAGAAIRLALFLGIPSLCHALERRPELSTPLTSFRSLKEGVFIHDQGSNPYDGGVFFHSPLYLLFFTYIVPVSSYLLTLLLWTSVDIGSAIALVRIWKSQNSKRNERKVSLILALFLFNPYTLLSCLAKSTTSIDNAILLSAIAFAATGQITGATFLLALASHASLYPLLLLPPLAMLLKQKSGTHLASPVLLTAVSFVLFCAGLTGIIYLTASQSWIEQSWGVMFSINVNDLTPNVGMWWYFFTEMFDHFRTFFLGVFQLHNLIYVAPICLRLSDDPLFAILIQVGIISTWKSYPALGDMAVWAGLLGCFPDVVSNLRHPLFTLTVHLYTSILLPLLHSLWLLTGTGNANFFYAATMVYGLNASLAVVDALGAGLRLQVKKQATDALLREESEDRKSDGYEKDPEMMDEIWEQKGWSVVQFASSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L6I8</accession>
    <name>A0AAJ8L6I8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_103966</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011149.2">
        <property type="nucleotide sequence ID" value="XM_019156191.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L6I8"/>
    <dbReference type="GeneID" id="30172830"/>
    <dbReference type="KEGG" id="kpin:30172830"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd23814">
        <property type="entry name" value="UEV_AKTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="3">
        <location>
            <begin position="22"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC70022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="234" mass="26570" checksum="13EF0211E46F2B36" modified="2024-07-24" version="1">MFSSPIRSPRPIQPVVSDISPLLATELAIEFNSLRSPKGCPEGIYITPCKDSMLRWNGVFFVHHGPYAGSILRFTLLFPPTYPQNGPTLRFDSDVFHPLVDPKTKIWQAKGRLSIWRPRVDHVSHLLHALKKSFKTKAMDSIAEDEASNKQVWSLYHHSHQTFLSLTTQRSLHSASRSTLFPENYPAPPSPSRTRKISGQSMTEEMGKQAIRFMELDKDEESSLWEDLKASLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L721</accession>
    <name>A0AAJ8L721_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">catechol O-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_104462</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.6" evidence="1"/>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059056.1">
        <property type="nucleotide sequence ID" value="XM_070202955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L721"/>
    <dbReference type="GeneID" id="30172326"/>
    <dbReference type="KEGG" id="kpin:30172326"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016206">
        <property type="term" value="F:catechol O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006584">
        <property type="term" value="P:catecholamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836:SF2">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13578">
        <property type="entry name" value="Methyltransf_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0128">Catecholamine metabolism</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC70511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="333" mass="36734" checksum="3CCC3E43CA1B7630" modified="2024-07-24" version="1">MVTTSRSKPQAQAPQKYHEPVQGTVFHGDGREEALLKHLQSLPSLSAEETSSLSLQDRSQRVLDAIHEFGKGENRYLMSVGDTKGKQVEELVREKKPKLVLELGTYVGYSGISFGRHLLELHPGSVYPGDWTSNTEEDRAGYISLEKSEVYATTARGGFKLAGLEKVIRVITGSSTTSLKSLRETLNMPQPLKFDMVFLDHLKPLYTIDIKVLEEEGLVGPGTVLVADNVVKPGNPAYLSWVRATPEQKRKSLQAPRLTTQPPVTPNPPTEDWETAFHGGPIDETRWAPEEAEGITAEGDPGLIYTSEMLDGWDPYTGEKDACEVSVCTGRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L839</accession>
    <name>A0AAJ8L839_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_105896</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC71937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010248.2">
        <property type="nucleotide sequence ID" value="XM_019156446.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L839"/>
    <dbReference type="GeneID" id="30173085"/>
    <dbReference type="KEGG" id="kpin:30173085"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF3">
        <property type="entry name" value="CHAIN DEHYDROGENASE (ATSC), PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WWC71937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="25525" checksum="453A5EB77E7BECFD" modified="2024-07-24" version="1">MTVVLISGVNRGIGLGLFKQYAAREGYTVIGTILPLAEKIPEIPIGKGSKAIIVNMDVTDVQSPKRAIEELETKYGINQIDIAISNAGILTLKAMSRIENIDPQEFEDHWRVNVKGYLLFFQASLELLKSGSKFIFISSSAAILDRIPDKQNVCYGITKIGATYLARYAHFEHPDLIIFPICPGWVATGMGNLTAQHRGWDKAPVTVEQSASGLIKVIDEATRETHSGKPWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L9D1</accession>
    <name>A0AAJ8L9D1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA-(apurinic or apyrimidinic site) endonuclease</fullName>
            <ecNumber evidence="12">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I206_105929</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9 12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="9 12">Probably binds two magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="12"/>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC71970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010284.2">
        <property type="nucleotide sequence ID" value="XM_019156482.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L9D1"/>
    <dbReference type="GeneID" id="30173121"/>
    <dbReference type="KEGG" id="kpin:30173121"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09088">
        <property type="entry name" value="Ape2-like_AP-endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
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        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="AP ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748:SF4">
        <property type="entry name" value="DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GRF-type" evidence="14">
        <location>
            <begin position="642"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="371"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="450"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="408"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="456"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="469"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="514"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="527"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="564"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="10">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA substrate" evidence="10">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WWC71970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="715" mass="79877" checksum="6AB19DB1AB11B906" modified="2024-07-24" version="1">MRILTWNVNVLRTCLDYHPFSQMKKKNVEGLLDELGAQIYCFQEHKTPRAKLEKSMAVPGPYDGFWTFPRSKTGYSGVCTYVDSRYCVPIRAEEGITGLLLDDNKGSTMKPPWSEAERIGHYPETEEMAWMDEVDGKDFDVKRLDMEGRAVVCDFGLFVLFNLYSPNETNETRRPYKMNFLQCLQQRVKLLQQAGREVIIVGDINIMRAPIDSGEGGIRTSAEQHYEHPARRILDDWCAPKGPMVDVVRESWPDRDDMFTCWNQKLDARSANYGSRIDLILCTPGLRPWIKGGDILNKVYGSDHCPVYIDLYETITDPEKGEIHLRDMLNPSDRPISTAPIYPNTVPRTMPEPPRFATKFFDEFSGRQTTLRSFFGGGGDGSAQRNRKEPSASPTPSRVTATPAPADSTPNGFISSQVEQSHSKPIPDANEAVTTPFSLARAAFDAMDEAHQAGPSITSVPSASSSMSQHKRMPLSPRRHSSRDQAIDMTSDDEGADSHSGIGTESAKIISLAKPKSSKTNSKPSPAGQTKLSLFFSQPHPPPKAKRNLSSSPAVEPSVKQARRSFSNSTVPQSLSRSPSISKNTNEAVETPIEECKTGWTEAEDELVNQAIQQAEQDRKMKNDMAKPVWGDLFAKKLPPLCTVHHQPCKDFLVNKPGPNKGKRFWLCSLPVGAGYDTGRSKRPREDVNHKFRCDFFLWDSANSRKEKVGDLKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L9H8</accession>
    <name>A0AAJ8L9H8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein-tyrosine phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_106666</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059479.1">
        <property type="nucleotide sequence ID" value="XM_070203378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L9H8"/>
    <dbReference type="GeneID" id="30175813"/>
    <dbReference type="KEGG" id="kpin:30175813"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF449">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="51"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="178"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC72702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="30392" checksum="B393F57A060474D4" modified="2024-07-24" version="1">MARISPHTLERVYNILAEREYIRSRAGQLSQPSSEQAFYSVRNSVKHVLDNRYRNIYAYDRTAVIVDGKYLNANVITDGKGGLWIAAQAPTPRTFDTFFQALYSGAASGNKSKHVILLTKRDHVMEFLPIKPIKQERYEDMSTDMKELLLGQTDPTTLLHYHFDSWPDHGVPEGKAVQALSKLIDEVEQRRQSLNCEVWVHCSAGVGRTGTFIALSSLRRPGKALNNSPLPPLPGDLAQDPVAATVDTIRECRAILVQTPEQLELIYKMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LAM5</accession>
    <name>A0AAJ8LAM5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_107781</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059696.1">
        <property type="nucleotide sequence ID" value="XM_070203595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LAM5"/>
    <dbReference type="GeneID" id="30174483"/>
    <dbReference type="KEGG" id="kpin:30174483"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="176"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC73809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="360" mass="39847" checksum="87FE0D81A4B06188" modified="2024-07-24" version="1">MSSIEETAREQVTGNLGSHLSPLLLGMGVDALLLGISINSFCRWWTHSKKEATHVRFLIYLASIGGIIGTIFTWATTLHMFSYSYGSYSQFLKCDWIAWYGIIDPLTKISIQAFYAERAWRINKRNYLILISIGICLCLSVTGSVGYAFTVHTRTMNDFETKANLFFYLWPGACISADLIITSSIMYGLYHSRSGLEHTDRLVKKLMRVSLEAQIPPTIVALLFFLQFAANSMSSIVQFIAIIHPKVYLVGCLAILNSRQDIRRDRQRSYVYASGGTGSFGSSSLSSRTAEKMQSNGGIKVETETYICSDGPVTPPVDTANRSFSDIKVIPPSEDGDSEAIGLAECGALSTPLEFEVKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LBI7</accession>
    <name>A0AAJ8LBI7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribokinase</fullName>
            <shortName evidence="9">RK</shortName>
            <ecNumber evidence="9">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_107756</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-ribose + ATP = D-ribose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="9"/>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059691.1">
        <property type="nucleotide sequence ID" value="XM_070203590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LBI7"/>
    <dbReference type="GeneID" id="30174458"/>
    <dbReference type="KEGG" id="kpin:30174458"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="Ribokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584:SF166">
        <property type="entry name" value="RIBOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 9" id="KW-0630">Potassium</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="10">
        <location>
            <begin position="8"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="16"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="44"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="245"/>
            <end position="250"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="282"/>
            <end position="283"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC73784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="334" mass="35945" checksum="3FA73D4D3A93B939" modified="2024-07-24" version="1">MPSSSSPKCLVRGSINIDEFFALPHIVRPGETISSTSLTKRAGGKGANQAYAVAKAGGNVDLDGCIGQDGEWVRELLKSGGVGDGRLETLKNELTGRAIIQSASDGENSIVLHAGANHHLSSSSSSPNLQNYTHILLQNEIPLSSTLSYLEESGKKGLISIFNPSPMLSSEELRQFPWKDLSWLIVNEGELNDLLNAFNSNSSENEKQKNIDDLDLEELIKIASKGILELHENSFFSKKINIICTLGSKGILYFNPINGNKDIGHLKAGKLLNKLKDTTGAGDCFAGYFVAGLMRNEPLEKVLKTCLTACAICVENEGAMGSVPNIEATLARLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LBP0</accession>
    <name>A0AAJ8LBP0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Receptor-activated Ca2+-permeable cation channel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_106860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC72896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059519.1">
        <property type="nucleotide sequence ID" value="XM_070203418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LBP0"/>
    <dbReference type="GeneID" id="30173963"/>
    <dbReference type="KEGG" id="kpin:30173963"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056337">
        <property type="entry name" value="LHD_YVC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056336">
        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF1">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23190">
        <property type="entry name" value="LHD_TRPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="486"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="YVC1 N-terminal linker helical" evidence="3">
        <location>
            <begin position="32"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="4">
        <location>
            <begin position="245"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="754"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="697"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="788"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="826"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="870"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="906"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="954"/>
            <end position="969"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC72896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1031" mass="113547" checksum="91F669D1C879874E" modified="2024-07-24" version="1">MAYTPGEATPLLGPNSAGCPSSKILSETQVYPLIHLIRVDIMAHIDAPLTYEQLLAPESTYTIVRPLTEKYLELQNQATVFCLLLNKVQFTSDSNQLSISTLSTARANLCEILSIRVLRGWSERSLPLATVLLTPWALFQGASQEVLERAKEEGDDELITQGGNALEMAIISGSKRFIRSPSCQKVIEGIWTGKIIYSALNAHALIADNYKKKPIQMYNPHKAPLLDHYRLKVPRVRSMLEYINFLILFTLYIVAIEGLQEDKLNGRELAFIIYALAFSLDKLAAIREHGLKVFSSSLVNGFDLVFMVIYAVYLGARTYGFHYHDKSALDLGSDWLAIGAVLIFPRLAFVTLANNLMVLSIRSMLTEFFFLMSVGFFCFLGFLYALFTLGQGKFALSQIGWWLLEVYFGLDASGFEHAHVFHPFLGPVLMISYALLSNTLLLTVLVAILGNTFATINADAAAESMFRKAVSTLEGVKADAVFSYQLPFNLVAVVVMWPMSYILGPRWFHKVNVTMIRVTSVPVLLTIALYERQSYREQTLMEQFGDFAERYVGNLPRRIKAAAGFDTFGSRHDIETVFEIEREVGDFYSGWDDDVFEESDFALPPPIDSTPTSSDDEGQTLRLGKKESSTPLSGATPTNLMFPDTGMTSSPSALEHNIESGKPPSEGVPSPRPPARRRTSSMPSQPKSPNIEIRPRYQSTAQQAQGQVTRPRRNSSMQIHGPSPLAQLFMMASPENDRLYHHGRKNSMALSTSHPALSSMLGPHRRKSSLQPSQNAKSPPKAPLPSERIAESPLKGDDLGQKVASRLNKSNLALGRPAISPIIESRQASFSGVTSKSLVDSTASEGSITPTPTVSKGKAMPNLFAPPTPSMSKGSSSTSTFDQKEDQAHSDVSLPLPDLDLRKDSPSPSTTPRPSSTTRSVRFPRSPSSSSLNPPSASTGSTTPPTRSGSPSSQLRLPSASGSFINTGPKSPRPNILKASQVEAMQLNRPEEDRQLEIGMDKRLEGIEKRQKRIEEMLERLCRASDGSRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LBV0</accession>
    <name>A0AAJ8LBV0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">serine C-palmitoyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_106357</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="5"/>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007991.2">
        <property type="nucleotide sequence ID" value="XM_019158853.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LBV0"/>
    <dbReference type="GeneID" id="30175528"/>
    <dbReference type="KEGG" id="kpin:30175528"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF2">
        <property type="entry name" value="SERINE PALMITOYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="11">
        <location>
            <begin position="151"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC72395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="552" mass="60293" checksum="7511985FD53A282B" modified="2024-07-24" version="1">MSAVQFHSPTMIATARSASTEIPAPLIPLLSSLTALIYTIENLFNRLPGSPIILRYIKSSYQDDPWRSVLELFLLAFALRTLFKGRTRGEGEGKSFIKLTEKEIDELVEDFNPLPLADEPTPADSMTLETVPTIYGPNGIKVKTSPNGKTLLNLATPNWCGFVENDKMKEVAIETLKRYGVGTCGPSGFYGTIDIHQKAEADIASFLGTEASIIYSQAFALVSSAIPAFAKRGDIIVADRGVNFGIHKGLQISRSNIKWYAHGDMKDLERVLQNVERERKRKGGKLTKTFIVAEGIFENDGMILDLPKVIELKKKYKYRLILDECQSFGMMGAHGRGITEHFGVPASEVDMILGSMANGLATGGGFCAGSQVVCQHQRINSSASVFSASLPAMLATCASAAIDILKSQPQLMNSLQVNIQVFRQQLSKLEPFIPTTSASGENGLMPPPNGIPNKDALISIPSHANSGLIHIFLLNPPDNLEDEEIILQQIVDEVQQSSNVLITRSRRLRSQEIFEPEPSLKISISGFMSKKDVEAAGKGLRHAIVKVCGSEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LCN4</accession>
    <name>A0AAJ8LCN4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_106779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059500.1">
        <property type="nucleotide sequence ID" value="XM_070203399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LCN4"/>
    <dbReference type="GeneID" id="30175702"/>
    <dbReference type="KEGG" id="kpin:30175702"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042535628" evidence="1">
        <location>
            <begin position="20"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC72815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="87" mass="9724" checksum="49406441DCAEE1A8" modified="2024-07-24" version="1">MKFTIAVITFITLGLQVKADKYANFFTDEDCNEDGSIGFNLDNPGCFNQANMKSVYIPNNPLDWNQHYALVISSYRFIGGGCDVNNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LDT1</accession>
    <name>A0AAJ8LDT1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GTP-binding protein ypt3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_107744</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059688.1">
        <property type="nucleotide sequence ID" value="XM_070203587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LDT1"/>
    <dbReference type="GeneID" id="30174447"/>
    <dbReference type="KEGG" id="kpin:30174447"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01868">
        <property type="entry name" value="Rab11_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000067">
        <property type="entry name" value="ras-related protein RABA1f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC73772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="22761" checksum="9562BAF4F9103F51" modified="2024-07-24" version="1">MSDGSNYDYLFKVVLIGDSGVVLSRFTRNEFNLESKSTIGVEFATRSINVDGKTVKAQIWDTAGQERYRAITSAYYRGAVGALLVYDIAKHSTYENVTRWLKELRDHADANIVIMLVGNKSDLKHLRAVSTDEAKQFATENGLSFIETSALDASNVESAFQNILTEIYRIVSSKSLESSGDVIKPSGGETILVTPTDGDGGAKQGGKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MMB4</accession>
    <name>A0AAJ8MMB4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_101324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058469.1">
        <property type="nucleotide sequence ID" value="XM_070202368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MMB4"/>
    <dbReference type="GeneID" id="96955700"/>
    <dbReference type="KEGG" id="kpin:96955700"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22744">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF11">
        <property type="entry name" value="OTU DOMAIN-CONTAINING PROTEIN DDB_G0284757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="1">
        <location>
            <begin position="67"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC67416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="208" mass="23545" checksum="D494A6368A17D751" modified="2024-07-24" version="1">MLRWFSKLIISGTVDKAAVGLKSLGLARAEANRPKTYKIHNITHKVHPFKPPAYTTLERLNSKPVTYRTRWTDPDGNCLFKALAKAMGSPQVTHQDLRLKAVNYMRDHQEDYERFVEIGKDDPPGEDLAARFNRYLDNMAKDGTWGDHLTIKALCSVLNIAIAVLGKMSDGTFSWMRTGSDPKGYIALSLVSEHYENLFSMQEVFPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MMR9</accession>
    <name>A0AAJ8MMR9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein PNS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_100739</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Probably involved in transport through the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058369.1">
        <property type="nucleotide sequence ID" value="XM_070202268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MMR9"/>
    <dbReference type="GeneID" id="30168957"/>
    <dbReference type="KEGG" id="kpin:30168957"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF88">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE PROTEIN CTL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="474"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="615"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="642"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="679"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="715"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="29"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC66832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="775" mass="83533" checksum="5DFF2E06C1D5B145" modified="2024-07-24" version="1">MSNGVQNSQAGPSAFKAYASRFLSGQMNKDVEGSQIFRAPSPPSPSRDPFAPSPSITSSHPHLAGGSRSPSISGNQTPPFPGPGIEGIPDIDESGLGSGIGVGLLFAEPQDGQSENAPPPSVRGNKGKGGQVKSNIPNPYAASSSESEEEADLDEVANVRRSLLTRPSQQSQKKPPQSERARKGWLAHQSVFPPSSSSSSDEDSDDSDKQTESASEEDEPRMMGNRRKSRSRSRGQEDVGESQGYMLSPSELYNVSTGLQDAYDGPSNLEEPLLGPDELAGGRRGRVPIKLQVYHGRFGHWEREGLRKYKDSGFLALWLSSLIGIIIGLGFVWGSTDPPPTAPDTSPKSAPSIVPLLPLLLILLIPTLVLPPAFLLLLRKTVRPVLLATAISIPFSLFICGWWALGESFDTSGLSGVEQGERWWGTTGLRLGAVLLWLLAAWFGRLVWIRRKRLDRTASVVELSTNLLLTHPPLLLLTPLLLGVFALTSIPFLTLLIRLGTIGYWRHPRENTWVFHIRPYAGWLIFLVTLVWVWTWGVIRGVGRVAVAGVVGEWFFHRDDQSHPPPLEITTAAVHRATGTSLGSICLGAGIIAVVRTVGRGAAEMKRITNPKSRILPTPLHFLTNLTPLFAIVAGILDQLNGYALVYVGITGEAFWPSARRAVGLAGRRKGGRLLDYTLIKLLLTLSSTAMGLFTGTAGYLYMTHSLSNPGYAPLAGLLCGGLPFLAIRAGAAVLGDAADALFICYQIDRELGGDHCEEAKEAFAGELPRNESAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MMT0</accession>
    <name>A0AAJ8MMT0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_101010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_070202316.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30168685"/>
    <dbReference type="KEGG" id="kpin:30168685"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051425">
        <property type="entry name" value="Formin_Homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725:SF1">
        <property type="entry name" value="DISHEVELLED ASSOCIATED ACTIVATOR OF MORPHOGENESIS, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725">
        <property type="entry name" value="FORMIN HOMOLOGY 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="3">
        <location>
            <begin position="396"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="4">
        <location>
            <begin position="1156"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="246"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="385"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1005"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="796"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="957"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="267"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="351"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="399"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1010"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1026"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1042"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1057"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1067"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1083"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1099"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1127"/>
            <end position="1149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC67103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1691" mass="187626" checksum="5C50416B20A882BF" modified="2024-07-24" version="1">MSDITITVYIPILGGVVVVLPTGSTAQDAIDLAFLEAEETFGEDKLVEALNEKTADPENIWKGEDTGDEWTLKEKRNLENGKWWNEEDIVSYHDSILDLNDIIISQKLFTLIRPHTPLLQVSILLPTTSSSIPLRTTSIFHEMSIFSDIISELQIELGLPKTSDDLIGPVSMRKMTSRSRSSSLDNVTGANIEKSDIVKWKIRIGEREVHLEEKVKEVMRSHECDVVDISLDEDWIFERKETDNVSRTPILTSQPADAESEEEESQKSTLKPSTSQPLNSGLKGLSSSTSFQSPNLSNELIDGLPNDNNTHSPILSVSPPAQAISPPRPTTFISLSTGTSAGISRLLPQFTGGTSNAGTGSTPATPNRGKEGGWKRFSLAGLGVWSGDTPGKGEGLTPPREESGGERMLRRESSAAEKALGEVGDIKPIEKQSTGGLWAWWTGSNKVEGESPSEYIDALRLSRKNHQPLLKHLLSLRGTMSTARTTWISEFILLDGLSALSSVLNRLSKEQRQKADIGEQVIGEIAKCLRILMNTDVGFSAVLAYHDLLTNTVLSLRVPSYRIRNQILDLLTAVITLSPELGSKIVLNALSEMRILNNDKYRFSWLLESLKPAEPLLEEQGIWEWRSGILNLFSALCNASEEVEERLEIRGELRRRGFQDTMQVLERLEPPTSFLSKCASYMDDQEDDLMEFRELFLGEVQNADLAVAVGRLLSAIGGDEVNGLVEVIEELTEITSSFHTRDTTTSILACFARHLSGLDDLSADWSSLLRSFLVDLDDILLTAQAGRKGTNEGALIESYVHEVHALQATSRELEERNNMFERQNEQHSAELVVLREIIGAKYDGDGFVHYLVVKEKEIQKLQTELLALEGQIGPQRNVGANNELRDRERLRFDALLEEIGQLRNQISERDREMAERHKEVKYLERALQTIRSKFNVRIPTREHRLEQTIHLDADLIATEAVKNWAKQEKTIEKLQKEVETLHQAKERLREAQRDQTRSGLPILQCCAPALTPPPPPPPPPPPPLLTSASIPLSDPTVSKATPAPPAPPPIPSLPLMSCQSGIQNATAPPPPPPPPRPLPSYPSTTLAHPISASSSDLAGPPPPPPPPPPPPPPPMLGPSIKPTAIPLAPPLPPAPPSGIPMPPPPPPVAGPSRRRIAGPSQAQSKLKPFFWSKMPQYAVKDTIWTSMSSSDDLDLHFHDLVEVFSLNSGVEKVEKVKGKSKEVITVLDITRSNNIGIMLNRLRLSPSKIRRAVVEVDDDLLDIDDLATLSRMLPTTEEVERIKAFLGDTTKLSKPDLYFREISAIPHLKIRLETMVFRRKFEMMLGEIMPDMMILRNVTKELRDSKRLKEVLKVVLALGNRLNGGTFRGNAAGFQLEALSKLKETRTAKGPGCPTMLHYLAKILIRRDRALISWGEEIPSLEPAARIVLSELSSSIFEMTTSIGTPRTLLPLLTSDDSLYPSLEEFLKEASPKIDQLKDTFDEIKIDLINLSRYFGVKTDNEGEVEKIFGILSSFSRNLEIASNEMTITLLKEQNTGISISTTFSNSTTITESSNNPTIDTNNDQIVISPLTPSSYNKEEVEHKRQPSIQTLLKRHENLSNLTIRKGQVDETIRTIHSGSIRRPSRKEREPSLWNTLNRNYGNSRITNPGFGANRNSLDKKEDKFRLSKMFLDGGTGGSVRGTIGDKSISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MQZ2</accession>
    <name>A0AAJ8MQZ2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">I206_106640</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059467.1">
        <property type="nucleotide sequence ID" value="XM_070203366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MQZ2"/>
    <dbReference type="GeneID" id="30175838"/>
    <dbReference type="KEGG" id="kpin:30175838"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141164">
        <property type="term" value="P:mitochondrial protein quality control"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000002">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000175">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FTSH 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076:SF97">
        <property type="entry name" value="ATP-DEPENDENT ZINC METALLOPROTEASE YME1L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076">
        <property type="entry name" value="METALLOPROTEASE M41 FTSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="359"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="210"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="758"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="210"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="767"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="WWC72676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="787" mass="84609" checksum="61C18930EEFD5121" modified="2024-07-24" version="1">MTAPFRQIHTLEQVLGYNRVRTSRLLQVKSSLKLSTPAYLNRSVSTCVPRRAIFGTTSNSAKQLSPPPPAIDSDTPLTPFQSQIAALESAAQANPEDLNAQVQLLGELAKGGEFKGLVAYYEAMALTSSTDKSTGVGSTALLKDENAWTLFLNGLANTGRLGEASQLVRRRDELMKSTNTALRAPINDPSSASSVPPASASVLTNLASTSSHADSSTSSTSASTPISSASQSPLSSFISPTNNGLSSPTPASQGGSGSALNPLYVQMAPPTPQANAWKALRWLGGFLLWGFIILTVMSMIMENTGLLKAGPGPAEFEPEEGKVVKFSDVHGVEEAKSELEEIVEFLKNPEKFSNLGGKLPKGVLLTGPPGTGKTMLARAVAGEAEVPFLFASGSSFDEMFVGVGAKRVRELFAAARKKAPAIVFIDELDAIGSKRSAKDQHYMKQTLNQLLVELDGFEQSEGVIIIAATNFPESLDKALTRPGRFDRHVVVGLPDVRGRVEILKHHMGEVAFDVDVDASIIARGCPGMSGADLQNLVNQAAVKASREGAKTVGLKHFEWAKDRILMGAERRSHFVTEESKRATAYHEGGHALVALHTPGAMPLHKVTIMPRGQALGITFQLPEQDKDSYTRKEYNAMIDVALGGRAAEEMVFGHDDVTSGCSSDLQRATDVAARMIRSYGFSDKVGLVAHGDEESVYLSGKKKDEIESEIRSFLDGSMDRTKQLLRTREHELHTLAKALVEYETLSLDEVRQVLAGQSLNRPTTEGETLKSEEEIRNQPGGKVVEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MTB8</accession>
    <name>A0AAJ8MTB8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_107125</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC73159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059554.1">
        <property type="nucleotide sequence ID" value="XM_070203453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MTB8"/>
    <dbReference type="GeneID" id="30173700"/>
    <dbReference type="KEGG" id="kpin:30173700"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23792">
        <property type="entry name" value="UBCc_UBE2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000010">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2-16 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="8">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC73159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="144" mass="16144" checksum="2ABDD42EF9F428CD" modified="2024-07-24" version="1">MALKRINKELIDLGRDPPSSCSAGPINDNLFQWQATIMGPADSPYAGGVFFLSLTFPTDYPFKPPKVQFTTKIYHPNINANGSICLDILRDQWSPALTISKVLLSICSMLTDPNPDDPLVPEIANTYKTDRPRYEATAREWTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HSB2</accession>
    <name>A0A1B9HSB2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Spermine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_07832</name>
        <name evidence="8" type="ORF">I206_100017</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV700119">
        <property type="protein sequence ID" value="OCF46162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007381.1">
        <property type="nucleotide sequence ID" value="XM_019159517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HSB2"/>
    <dbReference type="STRING" id="1296096.A0A1B9HSB2"/>
    <dbReference type="GeneID" id="30176201"/>
    <dbReference type="KEGG" id="kpin:30176201"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF48">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G02700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="95"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCF46162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC66117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="532" mass="58413" checksum="DB29D0E0F67BB3B1" modified="2016-11-02" version="1">MLEPIEAEFARPPIYTAEQEEALRDEEVESPGVLSQAGLERHRTQLSRVASTHLTRVGTHTPDSAEVEKGDGEILVEFQEGEGPRNWPKGKKWLATMSTSALCLTVALGSAMPTGDLSGTAEGLHVSDEAIYLSITLFVVGFGVGPLVFAPLSEIIGRKPIYCISMFFYFIFTLPSCLAKNIATMLAGRMLAGIASSAPMTNVGGTISDIWAVEDRGIPMAVFSSAIFMGPCLGPLFGGWISYKTGQWRWIYWVLFILVGVVFAATLIMPETLGIVILKKRAAKLNKANKTNRYVTAHQKLHQASGVTFGQTLKTAMIRPFILMFLEPIVLFMSFYLSFVYALLYATFFAFPIAFEEIRGWNPGMTGVAFLSIVIGIFFALFLMPIQEKLYARKPGCPESRLYPMMLGAIFLPISLFIIAFTGAYARVHWMGMMVGGALFGFCMVSVYISANSYIVDSYADVAASAVAAKTLMRSLIGASVPLWITQLFHNLGFQYAGLFLALVSCCIGFIPYIFFFKGESVRKASKRAMKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HSC6</accession>
    <name>A0A1B9HSC6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxymethylenebutenolidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_07922</name>
        <name evidence="3" type="ORF">I206_106534</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
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                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
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                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Nusbaum C."/>
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            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
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                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
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                <person name="Mohammad A.W."/>
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                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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    <reference evidence="15" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="Dromer F."/>
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                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
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                <person name="Mohammad A.W."/>
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                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
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                <person name="Cuomo C.A."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCF46644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WWC72648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="139" mass="15268" checksum="E317C038046BBBB2" modified="2016-11-02" version="1">MAPSKSSTTTKVSAHRIGSLLFCPACGTLLDLPRDEQDEIACHQCGRKEPASSYENLPTKTYSSPHAFPSTLRQKRALVQNKVQDGEAAKDRDPVAQEKCQKCGHIGLSYKEMQLRSADEGSTIFYKCLNCGDQTSTNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HUC3</accession>
    <name>A0A1B9HUC3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH:ubiquinone reductase (non-electrogenic)</fullName>
            <ecNumber evidence="2">1.6.5.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I206_07256</name>
        <name evidence="15" type="ORF">I206_106452</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a quinone + NADH + H(+) = a quinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:46160"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.6.5.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a ubiquinone + NADH + H(+) = a ubiquinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:23152"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.9" evidence="2"/>
    <dbReference type="EMBL" id="KI894015">
        <property type="protein sequence ID" value="OCF46869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008088.1">
        <property type="nucleotide sequence ID" value="XM_019158950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HUC3"/>
    <dbReference type="STRING" id="1296096.A0A1B9HUC3"/>
    <dbReference type="GeneID" id="30175625"/>
    <dbReference type="KEGG" id="kpin:30175625"/>
    <dbReference type="OrthoDB" id="3244603at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) (non-electrogenic) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054585">
        <property type="entry name" value="NDH2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF47">
        <property type="entry name" value="EXTERNAL NADH-UBIQUINONE OXIDOREDUCTASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22366">
        <property type="entry name" value="NDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="12">
        <location>
            <begin position="116"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="External alternative NADH-ubiquinone oxidoreductase-like C-terminal" evidence="13">
        <location>
            <begin position="498"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="36"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCF46869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WWC72490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="561" mass="61888" checksum="E8B91A1DEBD3C14B" modified="2016-11-02" version="1">MALRQLVRARPLLARPAIAPRSAFLAPRLSASFTSTPKRLDVPPQAYQIPPSEGPIPPKNQKPKPSFSARASKFAKTFGRVTLVVLLTATGAFIYVTQSQNSPPDQLPVDTKKPTLVVLGSGWGATSFLKSLDTEEFNVVVISPRNYFLFTPLLPSVTVGTLEPRSIIQPTRYITRHKKRKVDVYEAEAQEVDPVKKTVTFQDLSDVRGAAGSVTIPYDYLVYAVGCENQTFGIKGVNEHACFLKELSDADKIRTKLLDCIETAAFRDQPQDEVDRLMHMVVVGGGPTGVEYAGELHDFLIDDLKKWYPEVAERLRITLIEALPNVLPAFSKQLIQYTESTFAENKIDVLTRTMVKDVKESAVVVQDANKQIREIPYGLLVWATGNTSREITRDLMSKLSSVQTQRRGLLVDDYLNLLGAEGVYAVGDCTATSYAPTAQVASQQGIYLAGIFQKLGQKAKFERQLSELRATAAAPEEIEATVKKLNRAAKLTPFHYSHQGSLAYIGSEKAIADLPLFNGNVASGGGAAMLFWRSAYVSTLYSVRNRTLVLADWLKVKIFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HUV0</accession>
    <name>A0A1B9HUV0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_06821</name>
        <name evidence="5" type="ORF">I206_102086</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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                <person name="Litvintseva A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
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                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
                <person name="Chen Y."/>
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                <person name="David-Palma M."/>
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                <person name="Mohammad A.W."/>
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                <person name="Yurkov A.M."/>
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                <person name="Litvintseva A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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    <sequence length="2437" mass="278300" checksum="DCEA60278D7EBDBC" modified="2016-11-02" version="1">MANPDTAAREAITIVGVIGTFLLFSIFTWAFKRNKKSKGKGNGKGDEVKKDGKSSKGDDDGQNGKNRNDEDSKDRKKDRDDDKKSKDKDGNEDDKSNKEKDKKQIPDTPESTNFDPNKPSDDDSDDDGIPMIPSTIKDPVTSMLNSTFQLAPDFKLGIQNNDETPFKVNFHDTPTTAETPNTSNTQPNGGGWYGGRGGGGGGNSPSGGGGIGGIQTIPQTASIPIEYYNNRQSAGYIPPFIPYDIHTPITPNYNIPTSGIPFLNKTKQPITPIPIKRYSSFVPSLINSESSLSEDEIISPLTPSPIQIRNNELISDLIDPYFFTSAKPTKTSFDSNDLHYDDINLSKNKTNSIDLKTRRLSDLIGIPGLGESLYPSQGDKYNPTMFGDLKNRKGNKIPISPIKVPTNMSPIDLNPVHLTEKDDQEEEKVQTLSPLQPGLSPTKTGEKAKRREKERTKNGRTWDEIKGRYLSPRAVDLPTPLAEETKEARKRRKEIEQDDHERAKGRTSKEREKIPISPERARNKVKKMKKQQVKVVDKKTRRVKTEEILVTDVSDAERERLPERAKGRTKISIRDDVSEGEELYTKDGKKKNREKLRKKIRVDSEDEYISVDEDGRRLKKRNKKKLELSDEEEDERIRRKRKDKLRSGGYYSEEDIENRRKLKPNREKLRHERNRGAISDEEEEELYERYTDKRGQPKLRKLALDDPYVDTYRKRQRVRAGSDQVGGIEEDYEMDKFAQGGQGRLKRRQQVGYQDDIPVQSLPNQQQTYQQQPQLVQADPILAQRKVVEDEILRENPGMSRSEREELAQLPLKKMDNEENNFARKGRKLGANIQPDENDLEENVIEKRKKNRKPAETEVDNDGEVVAFKPTRIRAQRRQSKLKVEDDFLAEEQSQRTRRDVSGGVNDEIMLNAEGEEQVKLKHSVRAEKPAERATRKRDTMVCGKVTDPDFPQGPEEHLQQLHTRRIRKGSSDPLVAADTRSATQEVFIEQSATRHDTENGIDGSSPTLGVKEETATERKAHVLRDDGHVDHEDHDELRHQSRADMPEREGIDIASPKRETKVRRKHKAIEAPISLNNQRRDSLEPIPSPTKLEQGSKERQIGKAEVLDRARGEPEYQRWNRVIEREIASYKIRRNDQVILQEKSMRRWVKRKDSLMQGRNSSEEEDVLRDVVRGIVMKYENKIREDEIELEQLQDASHENSQSQVRQEGKTKPRRERINSDKYAKHMPEQQARDDSYRKARPESVDANREIVDVSELNDEEIAVFEKTGKLPSKHINRDDEPVREKPIRRKQRLALDDKPHRDHEEDDHDRSNQLISIRGDPVPDGDVDFGAPDATMRSKVGKTVPLVLSDGPSIDEDIDERRPLTPTSGKAHIGKFDDDEELYGVKTSSKPKQPVNLTNDSEALPKPRREVVINEKSATRQRRRDSGYESEGGELIVGDKNRPTQSHESLDPKSSQKVSTKQKIGHSQRKDSTDKDLFEHTDGVVPARYRDDRSNDERRVQRRSEGNTSHSGTRADSEQSTSINGTTKDDLDEYDEILSPKYSEDHNRLNPKSPLQHDVNSINYRKNHTIRSEKPSQIRLEREFDVNPKDEITKTREWPLRGENPIRELQRDLQVHTAFVPETRGDNRMIKEIVDDDSEESPKHTKPLVIPSGRKRSVPPKEIRREEGTPLEIGDELEGSDLRTMGHVRRDEKDKRRDQKGKPDVSDEKEDALDIQKDKGISRRKRNKKPASPISPLSPKAHRDILQNLEKNEAIRLKRVQEGKRAFDVSDESEVEEPVVKSSKSRNLKNGNILGSRTKDKDKQIGFEHSSRGKKESEGTDGTGTRSARNGNKKIIDKSSEDEDEDVPAAKRDRKKQDASLQRQARLEDTKDSDHERGLRDDKPRKGQDERKLRHAKTEVENGSQVKSKGGRQGAQRRNLEELKGENPQEDELSSDEDSQEERDGLMRHEARKARQTEKAEKTGRTSDGEGSRQGPRSPTQTLRRTRRDDQGVQDDIITDEEDEDFTEGRNGRHEEQKSRDHTEETDKTEKKSDQEKTGQSSEETFKATNSRKNNSRKVITENDSEYGDNEFREYHVDRISWKPKIHLKASWKILKNSPIWSTFSIIGFFLYVEITRQLFSLLAISSDSLVQSTSSELAKRDATVDDLGFDIKLTNTLFSNIIGTDDFESTSFFVFISLWNIICIPILGYLIYITLESASNPRDKKHSKSWLLWKLRRICQSSIKVILLDKRINGPRKLIKRCTLNTLSRISIFIFQLIGSILVFRQTMSLVYMAGTGSETTFSILPDVAATQKSLLEFAKSLTNGQIFAIVNFISIILLLNLACGWYVLLNSQAKTPLGNARSIFKWLLMSITTASFIICLFYFQDIANYLIKTHSGNTQDGGTIVLLGANIVFLTLVPAMGFVVYHLSKIWDRKFPGGIMKSIEGLMARFRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HWE2</accession>
    <name>A0A1B9HWE2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">I206_06483</name>
        <name evidence="23" type="ORF">I206_101544</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="23" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008799.1">
        <property type="nucleotide sequence ID" value="XM_019158186.1"/>
    </dbReference>
    <dbReference type="STRING" id="1296096.A0A1B9HWE2"/>
    <dbReference type="GeneID" id="30174852"/>
    <dbReference type="KEGG" id="kpin:30174852"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14879">
        <property type="entry name" value="MYSc_Myo17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036037">
        <property type="entry name" value="MYSc_Myo17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF45">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 16" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 16" id="KW-0505">Motor protein</keyword>
    <keyword evidence="10 16" id="KW-0518">Myosin</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="930"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="969"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1235"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1633"/>
            <end position="1654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1660"/>
            <end position="1681"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1688"/>
            <end position="1711"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="20">
        <location>
            <begin position="17"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="19">
        <location>
            <begin position="993"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="domain" description="DEK-C" evidence="21">
        <location>
            <begin position="1987"/>
            <end position="2044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="610"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="16">
        <location>
            <begin position="664"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="789"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="83"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="629"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="789"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="133"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="OCF47580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="WWC67634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="2046" mass="230729" checksum="D579FAC953BC3F19" modified="2016-11-02" version="1">MSAAGPSQSRGGYRFEGVTDLCTLGATLAEDTVLATLRERFLISQPYTTLSPSSLISVNPHAYLPLNGDASLQDYVAEYYRSQVDDETSRERDPESSTKSKNSGLGPHVFQLALDALYNMRRTRQDQIVVLSGSVGSGKTEIRRLAIKAISEVSVAAPGKKGSKVGSQVANAQFILESFGNAHTLTNDNASRFGNYTELQFNDRGRLEGLKTIEYYFERSRVSQTPSSGERNFHVFYYLVSGVHGEEKSFLKLENINSYRYLQSRVRRTGTDDRSRFEQLKQAFKTVGLSNRLVAQVCQLLATILHIGNLQFETGGNQHEGAIVTNFETLSTVAEFLGVSQEALAELFSFKTVLMKKEVYTTFLDPEQAESVRDELARTLYSLLFSWLNEHINQKLCKDSFGSFIALLDLPGMQNNHGPVAMSNSLDQFCFNFANEKVQNWVLHRVHENTLEEASKEKLTATRTPYFDNSECVKMLSDSKGGLVNIMDDQARKKKNESQFLEIMAKRFTGHASFSLSTQSRSGNSTFTINHYDGPVTYTTENFLARNANETSADILRLLRGTTTGAPVVSEHQGSNNPFIKSLFSSKSIATQAHPRNDDEIVAVQQPVRPMRAPSTRRRKGRPLKAVTEIEEEEGEDDEVGGGNDGGNAGKSLNCVAGQHWSALDTLLQTFDQAQPWLIFCLRPNDSQLPSQVEIRSMKSQIRSLGLTEMAHRLQNSYEVRMTHFEACDRYAEEFDIRGILKGPSDVDRLQDLKRVLGLSDSQMVIGANRVFLSHSIFHRFEDRLRAEERDEQRHRREDMEYLDDKDRKVDPFSPYNNNRDISPAASPALGYSDPYLQNESNVELPLVDHAQPLRQDSPDDFDEIRGFAPSQITSQFGDSNSNIGTETYAPSRNMFRDFDHKDEKDVLDLEPQDGEITEEYKESIARRRWVWLCTLLTFWIPGFLLSKIGGMKRQDIRQAWREKLAINIIIWFICGCTVFVIAFLGPLICPTQHVYTLSELSSHSYKNDPNNAFTAIRGEVFDLSQFAPTHLTAVSVVPTKSLMQYGGLDSTSLFPVEVSALCDGYGTNTISPYVTLDSTNTSDVFMQYHDFRAYTNDSRPDWYAEMMIMMRHRFRVGFMGYTKKDVKKMASSGRAVAIYDNLVYEMTTYIQQNGGGLKAPNGVSLTTEDQASRQFMAPQVVELFTYNAGKDITALLDGLSGTAGQDLVNKQKVCLRNLFIIGKVDSRDSPQCQFSTYILLALSIVMVAIIGFKFLAALHFGSSRAPENHDKFVICQVPCYTEGEESLRRTIDSLVRLKYDDKRKLLMIICDGNIKGYGNDKPTPAIVLDILGVDQNSDPEPLSFQSLGEGSKQHNMGKVYAGLYECAGHVVPYLVVVKVGKPTERPKPGNRGKRDSQMIVMHFLNKVHFNAPMNPLELEMYHQIKNVIGVNPSFYEYLFMVDADTTVDEMSLNRLVSAMMHDKKIIGVCGETSIANSKQSIVTMMQVYEYFISHHLAKAFESLFGSITCLPGCFSMYRLRSPDTHKPLFISNGIIQDYSENRVDTLHLKNLLHLGEDRYLTTLVLKHFNDYKTKFVRDAYAQTVAPDQGSVLLSQRRRWINSTIHNLAELVFLDQLCGFCCFSMRFVVFIDLLSTIIAPVTVAYIVYLVYLIVKEGKSIPTLSIIMLAAIYGLQALIFIFRLRWDMVAWMIFYIAAIPYFSFFLPLYSFWKMDDFSWGSTRLVVGEKGKKIVIHDEGKFDPRSIPLKSWNDYENELWDQESVHSGSYMPPVKGEYDSRPGSAYGYDNYDSKSRVLSPSGSYGDLRAQSRGGSMYNEVGMGVPQLPYQNRDIMGSPMNSNNHLPLGGGDTRSMYGDNRSLYGQPLNVDQRSMYGGSFYAGQPNFDNQRNSSYSLHSNMGIPTQMIMGNNIIGLNQRNSSYSTYNPPTVQQPQNQQQRINSIYDENQNKPITNFLGDTGINSSINQNDNENDNGFDNSSIGLTLGPQGITENQLEISIRKIIELNNNNLDNLTKKMVRKNLENEFKCNLNSRKESINRIIEVILAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HWE6</accession>
    <name>A0A1B9HWE6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_06494</name>
        <name evidence="10" type="ORF">I206_101534</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7"/>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008810.1">
        <property type="nucleotide sequence ID" value="XM_019158197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HWE6"/>
    <dbReference type="STRING" id="1296096.A0A1B9HWE6"/>
    <dbReference type="GeneID" id="30174863"/>
    <dbReference type="KEGG" id="kpin:30174863"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000005">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="8">
        <location>
            <begin position="112"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCF47591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC67624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="312" mass="35336" checksum="F8CA52F57A97006A" modified="2016-11-02" version="1">MSGLSSDPDQWIAHIRQCKHLPERQMKLLCSRVRDLLLEESNVHLVQSPVTICGDIHGQFWDVLEIFRQGGEPPETSYIFMGDFVDRGYYSLETLSLLLAYKARYPDKITLLRGNHESRQITQVYGFYDECLGKYGNPSVWKACCTLFDHLNLAAIIDSSILCVHGGLSPDIKTLDQIRIIPRAQEVPHEGAFCDLMWSDPDEVDSWSVSPRGAGWLFGGKVTSEFNHINSLSLIARAHQLVQEGYKHMFDNSLVTVWSAPNYCYRCGNSASIMQINENGKTDFKVYGAARENDTDLKNPAMRRMGTPSYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HWF4</accession>
    <name>A0A1B9HWF4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_06509</name>
        <name evidence="3" type="ORF">I206_101519</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008825.1">
        <property type="nucleotide sequence ID" value="XM_019158212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HWF4"/>
    <dbReference type="STRING" id="1296096.A0A1B9HWF4"/>
    <dbReference type="GeneID" id="30174878"/>
    <dbReference type="KEGG" id="kpin:30174878"/>
    <dbReference type="OrthoDB" id="4218123at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39470:SF1">
        <property type="entry name" value="CHORISMATE SYNTHASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39470">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF47606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC67609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="340" mass="38838" checksum="3452FCC239451F78" modified="2016-11-02" version="1">MSIFTPLVAYQAPLTLLLIIFGPSLLPRLINFFRRKPPSSIPNKTQTPRPLSLKLILGIHTIWMLKQLILPPFNLFSNVPISISNSQLRYNIIGPEQPNLTLHPMIELLLTRLKIMENRILYLKFGHNPLIECVWCQFPSDYLIYSLPQILSWYILEAFFIGSLGMSWISGISASNRAERWRSIFGWMLVGGAILEGGVKWIWDLRAVEGDALHLASTIHTIRSISLLLFPLIYTFLPIPLDPISPNILIPIISNTTSTLRLTSLARSAIQRSGKLREIWSDIGKRDAERNELAMRDEDIRDLVKELQLDQNSMKLSASQWIRDGWNGMIRIDSNPRHGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HX67</accession>
    <name>A0A1B9HX67_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Double-strand break repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">I206_05722</name>
        <name evidence="22" type="ORF">I206_107396</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="22" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 10737</strain>
        </source>
    </reference>
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        <text evidence="16">Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage. Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR. It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation, which is required for single-strand invasion and recombination.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16 18">Belongs to the MRE11/RAD32 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="WWC73429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_019157441.1"/>
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    <dbReference type="KEGG" id="kpin:30174091"/>
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        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:double-strand break repair via homologous recombination"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097552">
        <property type="term" value="P:mitochondrial double-strand break repair via homologous recombination"/>
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        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Double-strand break repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mre11, capping domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003701">
        <property type="entry name" value="Mre11"/>
    </dbReference>
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        <property type="entry name" value="Mre11_capping_dom"/>
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        <property type="entry name" value="Mre11_DNA-bd"/>
    </dbReference>
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        <property type="entry name" value="Mre11_N"/>
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    <dbReference type="NCBIfam" id="TIGR00583">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139:SF1">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 16 18" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 16 18" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 16 18" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11 16 18" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10 16 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 16 18" id="KW-0464">Manganese</keyword>
    <keyword evidence="15 16 18" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 16 18" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14 16 18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mre11 DNA-binding" evidence="20">
        <location>
            <begin position="329"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
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        </location>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HX88</accession>
    <name>A0A1B9HX88_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">coproporphyrinogen oxidase</fullName>
            <ecNumber evidence="4">1.3.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_05743</name>
        <name evidence="10" type="ORF">I206_107417</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aerobic coproporphyrinogen-III oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.3" evidence="4"/>
    <dbReference type="EMBL" id="KI894014">
        <property type="protein sequence ID" value="OCF47880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009099.1">
        <property type="nucleotide sequence ID" value="XM_019157459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HX88"/>
    <dbReference type="STRING" id="1296096.A0A1B9HX88"/>
    <dbReference type="GeneID" id="30174112"/>
    <dbReference type="KEGG" id="kpin:30174112"/>
    <dbReference type="OrthoDB" id="15318at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1500.10:FF:000002">
        <property type="entry name" value="oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1500.10">
        <property type="entry name" value="Coproporphyrinogen III oxidase, aerobic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001260">
        <property type="entry name" value="Coprogen_oxidase_aer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036406">
        <property type="entry name" value="Coprogen_oxidase_aer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018375">
        <property type="entry name" value="Coprogen_oxidase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003727">
        <property type="entry name" value="PRK05330.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755">
        <property type="entry name" value="COPROPORPHYRINOGEN III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755:SF0">
        <property type="entry name" value="OXYGEN-DEPENDENT COPROPORPHYRINOGEN-III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01218">
        <property type="entry name" value="Coprogen_oxidas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00073">
        <property type="entry name" value="COPRGNOXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102886">
        <property type="entry name" value="Coproporphyrinogen III oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01021">
        <property type="entry name" value="COPROGEN_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="19"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="431"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCF47880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC73447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="443" mass="50665" checksum="71DD9AC8A64D9536" modified="2016-11-02" version="1">MSLRTAALRAARSTSSSRSKISLSQLSKRGYSTPSSRPTSSSWRQQIATSFAVGLVGTVAYRYLSDNKSQVQCDGAPLVEAIETHGYPWVPVDALEKDDPQNPMRIRMATWVKSLQDHIVKTMEEIESSVEPNSFSPFKENPKFLKDTWIRKEGGEGSSCVLSNGRVFEKAGINVSIVHGLLPPKAQKAMLPDHPSLPEPKETKPFFATGLSIVIHPRNPHIPTVHLNYRYFEIENKNDENQQPITWWFGGGSDLTPSYLDEKDCIHFHNELKKSCDKNDLNYYKEFKKQCDKYFFINHRNESRGIGGIFFDDLTISSPINQINQNENGKPKTQEDLFNFIKDASSSFLPAYIPIVYKHLNRTWTEEEKRWQQLRRGRYVEFNLVYDRGTKFGLHTPGARIESILMSLPETARWEYMTPVGAEGSNSPEEELQKVLKNPREWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HXC0</accession>
    <name>A0A1B9HXC0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PITH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_05787</name>
        <name evidence="5" type="ORF">I206_107458</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PITHD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894014">
        <property type="protein sequence ID" value="OCF47923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009142.1">
        <property type="nucleotide sequence ID" value="XM_019157502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HXC0"/>
    <dbReference type="GeneID" id="30174156"/>
    <dbReference type="KEGG" id="kpin:30174156"/>
    <dbReference type="OrthoDB" id="2635at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045099">
        <property type="entry name" value="PITH1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175">
        <property type="entry name" value="AD039 HT014 THIOREDOXIN FAMILY TRP26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175:SF1">
        <property type="entry name" value="PITH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PITH" evidence="3">
        <location>
            <begin position="19"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF47923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC73488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="215" mass="23577" checksum="97E28E60C60A7484" modified="2016-11-02" version="1">MSCSHDAHDHDHDHNHSHDVPLDVSPLDSLYGQIDLPNVTALNAEGGGESGQKVIKSWDMRDDETSWCESEVDDEMIIKIPFTASISLRSITLKAGPSGKVPTSMKLFRDNSGLDFSDASSSTPTQEFDVVDIKDGVEYQVKAAKFNGLTSLTLYFPGNNSDGDEETTRIYYIGLRGTYQALPNRPGVIIYESSARPTDHKTEGVSSGQTFRPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HXF2</accession>
    <name>A0A1B9HXF2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_05811</name>
        <name evidence="3" type="ORF">I206_107482</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="Zeng Q."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
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                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
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                <person name="Imamovic A."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
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                <person name="Hansen M."/>
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                <person name="Imamovic A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
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                <person name="Zeng Q."/>
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                <person name="David-Palma M."/>
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                <person name="Mohammad A.W."/>
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                <person name="Yurkov A.M."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Alvarado L."/>
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                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
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                <person name="Imamovic A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="David-Palma M."/>
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                <person name="Bowers K."/>
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                <person name="Mohammad A.W."/>
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                <person name="Yurkov A.M."/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF48071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC73633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="160" mass="17900" checksum="90836C258BF2F411" modified="2016-11-02" version="1">MASNLHNLLSSLRSPIFQTISNPTSSRMGTKYLRRRLRGPSIASYYPQLTNPFPSISALNKTHPSNPFAGWQGSKLPEQLTTPTSGKVIMENVVWKNEGNMLRNSELVDEGFEEVSRKRGLGWLADGAEVRRAERVRARKTAGKGPPKKGHGRRSQMKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HXU6</accession>
    <name>A0A1B9HXU6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_05966</name>
        <name evidence="4" type="ORF">I206_107632</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894014">
        <property type="protein sequence ID" value="OCF48099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009318.1">
        <property type="nucleotide sequence ID" value="XM_019157678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HXU6"/>
    <dbReference type="GeneID" id="30174335"/>
    <dbReference type="KEGG" id="kpin:30174335"/>
    <dbReference type="OrthoDB" id="2524554at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF48099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC73660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="616" mass="66767" checksum="1D51343DEB08EF1E" modified="2016-11-02" version="1">MIRGTSRLLQPIVRRSIVLSPRSFSLSPPVPFSSTPKLTPIRLYSQITRRGPSSPPGHPSDTEYSDSTVYAFSYISRVIRYLLYGIVALGGVSLATFEGLHLYVENVCLAAPSRDGQDDPYGWIGENPGWTGGLKGGTDPRLGQKARHALRGAWICQEWGAGGSASSALSKSTGNGTSFHPDYVAVRGMIGNSQDGNLGIRQSIDRGYELAEEFINLSINEARKKGLVFPPNLSSSNTSIEPPVEKFENTHGIPQGDPAVLDLLLLKAGILERINTTDSLLHAKDLYQQVFTSMNHAPDEQHLYNQARVMRLAGKLGDLNARTGNADVALKWWSWGLDKAGIQMENNHISSVSQVVREVKKESKGWFGFGGSNKGSPTQPPAPTLTPESVNLDSSPSPAILRASISLLISASAHLATASSLTSAYSLQSQALSLIPSTTSLSVPTSSNADASLHATWLQHRSALLKLHQASVSHAQKFNSDEPLNLINEASKLSEGVISSIQNLPSAYTTPKSSSLNSPSRLLRRDALLTGAEINYTKAVFLERSLPLLKEEQIGQLEQAAECFERAMALNVLESGVEKKDGDEIGQGEEWGKYWRGFVRVRGKLNNLVNPPEKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HYD4</accession>
    <name>A0A1B9HYD4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="3 10">4.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_06153</name>
        <name evidence="13" type="ORF">I206_107820</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>orotidine 5'-phosphate + H(+) = UMP + CO2</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the OMP decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="3 10"/>
    <dbReference type="EMBL" id="KI894014">
        <property type="protein sequence ID" value="OCF48285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009504.1">
        <property type="nucleotide sequence ID" value="XM_019157864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HYD4"/>
    <dbReference type="STRING" id="1296096.A0A1B9HYD4"/>
    <dbReference type="GeneID" id="30174522"/>
    <dbReference type="KEGG" id="kpin:30174522"/>
    <dbReference type="OrthoDB" id="10263753at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04725">
        <property type="entry name" value="OMP_decarboxylase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000114">
        <property type="entry name" value="Decarboxylase,orotidine phosphate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014732">
        <property type="entry name" value="OMPdecase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01740">
        <property type="entry name" value="pyrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278:SF9">
        <property type="entry name" value="URIDINE 5'-MONOPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orotidine 5'-phosphate decarboxylase" evidence="11">
        <location>
            <begin position="36"/>
            <end position="258"/>
        </location>
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        <location>
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        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="8">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="8">
        <location>
            <position position="100"/>
        </location>
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            <position position="42"/>
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        <ligand>
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            <position position="64"/>
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        <ligand>
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            <position position="155"/>
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        <ligand>
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        <ligand>
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            <position position="243"/>
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        <ligand>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    <evidence type="ECO:0000256" key="9">
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000512"/>
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    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00934"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF48285.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC73848.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
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    </evidence>
    <sequence length="277" mass="30927" checksum="242B62A4EFA10769" modified="2016-11-02" version="1">MSPHPTTLIPYGERIKLHTNPTAIKILEIMNRKKTNLAVSVDVTTASEALKVIKRVGASVCMVKTHVDIFEDFTHEFTEELVKLSKELDFVIFEDRKFADIGNTVSLQYSSGIHKISSWSDLTNAHSVPGPGIISGLSKIGKPLGRGLLLLAEMSSKGSLAINEYTEKTFKMVKETDLNREFVIGFIAQNRIDKIELIKKGEDYLILSPGVGLSLKGDSLGQQYRTPYECIFESGSDIIIVGRGIYGIEGDEKAIKDEAERYRQAGWKAYEERLNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HZ67</accession>
    <name>A0A1B9HZ67_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_05366</name>
        <name evidence="6" type="ORF">I206_107090</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
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    </reference>
    <reference evidence="5" key="3">
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMP-30/CGR1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="OCF48587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1296096.A0A1B9HZ67"/>
    <dbReference type="GeneID" id="30173735"/>
    <dbReference type="KEGG" id="kpin:30173735"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0004341">
        <property type="term" value="F:gluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:L-ascorbic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907:SF47">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="4">
        <location>
            <begin position="21"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
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        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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        <location>
            <position position="138"/>
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        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="186"/>
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        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
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        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF48587.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC73124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HZP0</accession>
    <name>A0A1B9HZP0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_05538</name>
        <name evidence="4" type="ORF">I206_106917</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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                <person name="Litvintseva A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="Mohammad A.W."/>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="Heitman J."/>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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    <reference evidence="3" key="2">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
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                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
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                <person name="Cuomo C.A."/>
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            <strain evidence="3">CBS 10737</strain>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010378.1">
        <property type="nucleotide sequence ID" value="XM_019156576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I0U9"/>
    <dbReference type="GeneID" id="30173216"/>
    <dbReference type="KEGG" id="kpin:30173216"/>
    <dbReference type="OrthoDB" id="10620389at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628251" description="CBM1 domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF49159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC72064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="24532" checksum="F23A45E4BA918A3D" modified="2016-11-02" version="1">MPHKYFSKIIIGFISYLLIPVSAQRSSVIPTVGAIEYEYGHGPPNCTDYCNLNPEEQYKCDHPELPTTSTDTTTLIPGNYGTVNPATVQPLEHTSYSTTQTSAISTVSTSSGPQKADPTVYPGQNSVYDSKTATQHTSSCDPTCSYTDTRSFCTSTSSATTRTVGLYPTQPATTVKSDSVQSTANTWGKVLEDGFTYTSTSSKGAGFNADDSTSTVTSSDPSSSSTAEPTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I2F0</accession>
    <name>A0A1B9I2F0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">8-amino-7-oxononanoate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_04231</name>
        <name evidence="8" type="ORF">I206_104194</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010926.1">
        <property type="nucleotide sequence ID" value="XM_019155968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I2F0"/>
    <dbReference type="STRING" id="1296096.A0A1B9I2F0"/>
    <dbReference type="GeneID" id="30172600"/>
    <dbReference type="KEGG" id="kpin:30172600"/>
    <dbReference type="OrthoDB" id="2382073at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF77">
        <property type="entry name" value="8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="35"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCF49707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC70244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="443" mass="48939" checksum="C62FAD08602787B9" modified="2016-11-02" version="1">MTELDHRLDRLLEGRKEKNRFRSLKEYDITSNSGLVDFSSNDYLSLTSSSSLRRNYLGKLASTPSIFGSTGSRLLSGCTPSHSSLEKRFEKFFNSPSALLFNSGWDANVSFFATVPQPNDWVIYDELVHASVHSGLRASRTAVERRLAFNHNDPKHLEKLLKRMQNTASSSNDSSTIFVALESLYSMDGDFSPLPALLDVLEKYVPRKRLCVILDEAHSTGVYGDKGRGITHALGEEGGFDEGDTRRRGKGRVDVRLMTFGKAVGCSGAVLLCSPTVRSFLINFARPLIFSTALPHSTITALECVWDTLQSEEGDQRRQSLMSVARYVHTLLDDLLSRTPPGILHLPPDPMIPFLTSPNLAPKPGSPILGLLTPNPHALSAFLLDKGFIVRPVVPPTVPPGAERVRICLRAGMDKRVIEELVAALAEWVDIKLAEDRSVRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I2R0</accession>
    <name>A0A1B9I2R0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_04367</name>
        <name evidence="3" type="ORF">I206_104057</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
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                <person name="Litvintseva A."/>
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                <person name="Litvintseva A."/>
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                <person name="Mohammad A.W."/>
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                <person name="Litvintseva A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
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                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011098.1">
        <property type="nucleotide sequence ID" value="XM_019156140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I2W6"/>
    <dbReference type="STRING" id="1296096.A0A1B9I2W6"/>
    <dbReference type="GeneID" id="30172776"/>
    <dbReference type="KEGG" id="kpin:30172776"/>
    <dbReference type="OrthoDB" id="2121319at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38120">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38120:SF1">
        <property type="entry name" value="M PROTEIN, SEROTYPE 2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="702"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="753"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="567"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="647"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="702"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF49879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC70072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="774" mass="86676" checksum="237F997567B40AA3" modified="2016-11-02" version="1">MSLSVSPSSSSPLTIHSRPLPPNRKRNSYTPSPRATPRITPESSFADQGDVSILASPNVKQHDGTLGGLRERSEEELARADREELEEALKREWQHRDYLLQRIEQAESERKNLVNKQEELIKGMNALQARGDEAYNEQSRMEADLEERDELLERLRKRLADSERQARESQKRYIEQEQTFEIERQALQAQENHLQQRLKSLSSSSSSIRRSVTPTPPSDTENVSSLKDELASLNLSHSTLLAKLNTITKELHELKILNQELVEENEGWEFLVRERTMNGKLRQEGGLLSNEDEEEIYSEPRQNARLDPELEEEMSELASDLDNQSPIFDDDHQFFATNLDREEKWKSGQHLAPPSKSRKGKKDRAVSGSTPVEPNGSGLDLASELGKADEKPDENASVVSDSGKHIEIAALRSEVKQLKESNKALTLYCSKIIDRIIAQEGFEHVLSVDYKTRRATTRAASGSSTRPALKDVLNIPRGMTTSPISEESPAIVTTEPSIEPVKPKKARPLSMMVRAMTGPTEKSVPPAATQPPVTEESKADKRARRGFSLDFRSMGFGASSYTAPNESSKSSLRPLTLSSKSTSTSGRSSSARKLDIHEEDEEDRKERHRMEATMKLMGINRTPSPSIPEDPNEGNPSYLHQGKANWISSIRTSASSSRKSSETPLERLSSTIGMTEDNSISFEDVNDPKTAIQALKAFDEREAQKRKEIQKGKRNSIYTSPPKIGLGRRISIEHKEDEDLRNRTISKSESINTLWSIGGGDSRPNSGEIVLDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I351</accession>
    <name>A0A1B9I351_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glycosyltransferase 61 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_04388</name>
        <name evidence="12" type="ORF">I206_104037</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011080.1">
        <property type="nucleotide sequence ID" value="XM_019156122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I351"/>
    <dbReference type="GeneID" id="30172757"/>
    <dbReference type="KEGG" id="kpin:30172757"/>
    <dbReference type="OrthoDB" id="529273at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049625">
        <property type="entry name" value="Glyco_transf_61_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007657">
        <property type="entry name" value="Glycosyltransferase_61"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961:SF38">
        <property type="entry name" value="PROTEIN O-LINKED-MANNOSE BETA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04577">
        <property type="entry name" value="Glyco_transf_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 61 catalytic" evidence="10">
        <location>
            <begin position="285"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="30"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCF49861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC70090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="584" mass="65429" checksum="6DC765C48CA010F4" modified="2016-11-02" version="1">MSHSSNTHNLEYTNNLNPSITHTRKIIHTNSDENTLQPQSHSRENSNKSRRTSTSFNLGLPFASSSSSSNNNNNNRPLSNPELNTPTDIGRNFTLVKNSIRMSTKRGNRYVLGAIITLGVFAFWHISGTGSGNGSGSDSTNSRSSFGLWPTSGNVVSSLSVNNGENSGNIDPNEFIRFDEAHIPETEFIKGVAGFSYFKNLYLCNGTFIALTSNPSSIPDVTHIMSAHPTDDNKYPPAGLDRWKVMTLGQDDLSGFGGVAIRKDGISMFFNDEKGLKSVSFLKHYFHFIGEVFLGAWRVLTTAGETDLPRRLMYRTTPDDWRDRAGLTSWFQQSVMPNTAIEDASLWEDRAKSGMTFLFDKITITDRWAAHAKGIDPWRFNKMTADLLYLESPIGWMEPLRRSMKQLVQTKGCSVYRKKKDVPVVLYINRQLTGRRLIAENAKDLENEMIALEKEGVIEWVDAQMETLSRVDQFCLALKADIIMGVHGNGLSHALWMKPGSAVLEFMYPNGFARDYATIAELMRHDYYAIHGDHVFTKDKWLKDDGWGVGAIQGFHSTNIPADGKFISGLIRKIAQEKKSKIEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I361</accession>
    <name>A0A1B9I361_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_04517</name>
        <name evidence="4" type="ORF">I206_103910</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Sykes S."/>
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            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
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    <accession>A0A1B9I382</accession>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
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                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Shea T."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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    <reference evidence="8" key="3">
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <text evidence="2">Belongs to the RER1 family.</text>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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</entry>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CMC family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011468.1">
        <property type="nucleotide sequence ID" value="XM_019155314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I3Z7"/>
    <dbReference type="STRING" id="1296096.A0A1B9I3Z7"/>
    <dbReference type="GeneID" id="30171937"/>
    <dbReference type="KEGG" id="kpin:30171937"/>
    <dbReference type="OrthoDB" id="532630at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013892">
        <property type="entry name" value="Cyt_c_biogenesis_Cmc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08583">
        <property type="entry name" value="Cmc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF50249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC71572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="88" mass="9898" checksum="E705BCBF3E7134CB" modified="2016-11-02" version="1">MHAPLGNPGRQIACAELIEALEVCHAKGMIARLTGECNSQKSALSVCLRKERKDREAKNHESAKLRTIKKKQVWEELEKEKSQEVESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I409</accession>
    <name>A0A1B9I409_9TREE</name>
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        <recommendedName>
            <fullName evidence="4">alpha-amylase</fullName>
            <ecNumber evidence="4">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">I206_03569</name>
        <name evidence="21" type="ORF">I206_105529</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="21" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011469.1">
        <property type="nucleotide sequence ID" value="XM_019155315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I409"/>
    <dbReference type="STRING" id="1296096.A0A1B9I409"/>
    <dbReference type="GeneID" id="30171938"/>
    <dbReference type="KEGG" id="kpin:30171938"/>
    <dbReference type="OrthoDB" id="204980at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11319">
        <property type="entry name" value="AmyAc_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000120">
        <property type="entry name" value="Alpha-amylase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013777">
        <property type="entry name" value="A-amylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015340">
        <property type="entry name" value="A_amylase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF215">
        <property type="entry name" value="ALPHA-AMYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09260">
        <property type="entry name" value="A_amylase_dom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001024">
        <property type="entry name" value="Alph-amyl_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628361" description="alpha-amylase" evidence="18">
        <location>
            <begin position="22"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="19">
        <location>
            <begin position="34"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="13">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="14">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="50"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OCF50250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="WWC71571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="536" mass="57232" checksum="A4F52A203C0C62B4" modified="2016-11-02" version="1">MFTSSLFTLLPLLASIQSTFALDDTSARSASVYQIVTDRFARPSSVSSTCNTSDRKYCGGTYASITEKLDYIAGMGFDTIWISPIVENIGGTTGEGEAYHGYWTLDPDGFNSNFGSADDLKSLSSALHAKGMHLMIDVVINHVAATSSSTFQPDSAYGPFSDSSDYHPFCWISDYSNQTNVEDCWLGDDSVALPDLNTESSTVSDYWNNWVKTLVSNYTLDAVRIDTVKHVPKTFWPNFVSSAGVFTQGEVLNGDATYVGPYQNDAKVNPFNYPAYYPLLRGFNQTSGDLSELVAMTQTIQSNFNDPTLLGSFLNNHDNPRFESTVTDTSLIKNAHAYPFVSDGIPYGYYGSEAGFTGGADPANREPLWTSNYDTSSEMYKFFASLNAARKAAGNASDTFYSTQMNITSPSSSSILIAKQPLISILSNSGSSASDSSVTVQSSASGWTANTQVIDAISCETLTTDSSGNLAVTIKTGLPRVLIADSKKGSVCSSSSSSNSSSGTSSGKSAAIKLDVQAGWMISALGAVVGGLMMAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I4V4</accession>
    <name>A0A1B9I4V4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA repair protein RAD14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I206_03861</name>
        <name evidence="14" type="ORF">I206_105230</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPA family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011755.1">
        <property type="nucleotide sequence ID" value="XM_019155601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I4V4"/>
    <dbReference type="STRING" id="1296096.A0A1B9I4V4"/>
    <dbReference type="GeneID" id="30172230"/>
    <dbReference type="KEGG" id="kpin:30172230"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000715">
        <property type="term" value="P:nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21077">
        <property type="entry name" value="DBD_Rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.530.10:FF:000003">
        <property type="entry name" value="Dna repair rad14 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.530.10">
        <property type="entry name" value="XPA C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000465">
        <property type="entry name" value="XPA/RAD14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022656">
        <property type="entry name" value="XPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022658">
        <property type="entry name" value="XPA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037129">
        <property type="entry name" value="XPA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00598">
        <property type="entry name" value="rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05181">
        <property type="entry name" value="XPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00753">
        <property type="entry name" value="XPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="XPA C-terminal" evidence="12">
        <location>
            <begin position="184"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="25"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCF50536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WWC71277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="326" mass="37794" checksum="598FEBBF9320E45A" modified="2016-11-02" version="1">MSAPAPSLTPSQARLAALNRLKAKNKIIQSNNVESSSSSSRNPNPNGNGGANGHPYVHKANNVPSTSRNMVQAQQQSKEETQAPLRRDPGLGKYFEYDLSKLHNSRGGFLTEEDKEGDRIKSVIELAREKAREKQMMREGEEPAIRIDKSPRCEECNTLEINNQFLKVFDVKVCKTCEKKFPEKYSLLTKTECKEDYLLTDPELKDEDLLPHLLRPNPHASTYSNMMLFLRIQVEKVAWDKWGGEEGLDKEWERREVFKKRKREEKFEQGLRDLRKRTRNNIYQRKQEAEHIHQFEDIDEMIDDQGDKRVLQRCFGCGSEKEIEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I5A6</accession>
    <name>A0A1B9I5A6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_02751</name>
        <name evidence="5" type="ORF">I206_102404</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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                <person name="Heitman J."/>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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                <person name="David-Palma M."/>
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                <person name="Bowers K."/>
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                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
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                <person name="Cuomo C.A."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Gargeya S."/>
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                <person name="Dewar J."/>
                <person name="Goldberg J."/>
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                <person name="Imamovic A."/>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
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                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 17">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone deacetylase family. HD type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="3"/>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF50851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012070.1">
        <property type="nucleotide sequence ID" value="XM_019154667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I5T6"/>
    <dbReference type="STRING" id="1296096.A0A1B9I5T6"/>
    <dbReference type="GeneID" id="30171277"/>
    <dbReference type="KEGG" id="kpin:30171277"/>
    <dbReference type="OrthoDB" id="424012at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11600">
        <property type="entry name" value="HDAC_Clr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000005">
        <property type="entry name" value="histone deacetylase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019154">
        <property type="entry name" value="Arb2-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF5">
        <property type="entry name" value="HISTONE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09757">
        <property type="entry name" value="Arb2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="12">
        <location>
            <begin position="197"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Arb2-like" evidence="13">
        <location>
            <begin position="557"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="813"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="830"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="846"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCF50851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WWC68627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="856" mass="94511" checksum="5D36EC15B6D533E0" modified="2016-11-02" version="1">MSDPSYMEVDTSPTSRQADEDISFTKNISSIPEPIPEVEVEQSREEEQPMEIDPTTENQDQTVEGNSDQIGIIVEKTTTTTIETTSISIEESNLPQTISPAILTNGNHEIQIPEAEAEAEAEISNTNNFTPLPMTGNPSTLFGNSAYEITPSPAENRIIDRPKIYRTGYVYDPMMMLHCQEGYIPTSENVIDNGPGHPEEPMRIKRIFARLAEQGLIKRMLKLEFGQVVMEQVMLIHGEDLWNKVQGTENLTDEYIQQSKQYYEQLSLYVCRETAHCARLSCGGVIQACVSVCKQEVRNAFAIVRPPGHHAEPDEHMGFCFFNNVAVAAREVQRKGLAKKVLILDWDVHHGNGTQRAFWDDPDVLYISLHRHDGGKFYPTSDFGALDMVGSGAGEGKSVNIPWPGPGFGDADYIYAFQRIVMPIAYEFAPDLVIISAGFDAADGDRLGECHVTPAAYGHMTHMLSALAGGKLVVALEGGYNLKAISDSALAVAQVLLGETPAELEAHQASEVATEVIYQCAKVQSKYWKSIDVKSCEPPEITALEDGSSPVISIPDLLKLHRSWHMYEKHQLFQIPLASPELETAFGGQVMCSDGVYEVASKGVLVVFVHDFGNLRVETDGVASTNVHLANSYLINTSDDIVNWVKGEGYDLIDINVLKQLPTNFASDGPKMVSKSGPAMESQLIRYVWDNYIELSEAENVILIGHGTGCQTIMDLVNHREVEKKVKAVIQVAGLHSLVRPDPNNDSRRIWFRKANRIYVPSTHPVLEEERIQKRLGGQIFTSEKAKVVDLLNDVLPQIKQFVISKLPQMVQTNGNGNGNGNEHNHLDENLTLNGNENGNGISFGGENSNTPSIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I6C3</accession>
    <name>A0A1B9I6C3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_03151</name>
        <name evidence="7" type="ORF">I206_102797</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF51085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012304.1">
        <property type="nucleotide sequence ID" value="XM_019154901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I6C3"/>
    <dbReference type="STRING" id="1296096.A0A1B9I6C3"/>
    <dbReference type="GeneID" id="30171520"/>
    <dbReference type="KEGG" id="kpin:30171520"/>
    <dbReference type="OrthoDB" id="2576135at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033768">
        <property type="term" value="C:SUMO-targeted ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032183">
        <property type="term" value="F:SUMO binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140082">
        <property type="term" value="F:SUMO-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16449">
        <property type="entry name" value="RING-HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049627">
        <property type="entry name" value="SLX8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47094">
        <property type="entry name" value="ELFLESS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47094:SF1">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="322"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="110"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="211"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="356"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="43"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCF51085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC68861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="530" mass="58514" checksum="0FBAFA153D34217D" modified="2016-11-02" version="1">MRPPLRSTRNRSTNSPDSPESDLRPRPTLADVQIAPRRRLRDGSTSSRSSRGRRGTSVSSTASSLRSTSSISRNRNVNTSTTTMDFANNDNNNMSRSNILRRESLGSTSIFSESDGGSYIPSHSASIANSRESSLTPPPSEPIQHPILTTIRNHSPSLSAISPPHTSIPTRAQQSILDVMDAYEASQNPQRVVPHNRHLTDHSQHLINRNLRIGSPSSSGSSNPEEDKPLSEKRYTAAEKGKGRALVTPIEVESSEESEGNTIESANHEREDSIQVINLSREKRRRNSDDEEIIKHIVKENASDEVEDDIDEDHTLAGGYTCPVCFCPPNQAVMTPCGHILCAQCLHSSLLAAIGRNPNPYPDQQPHRGGRHGSRGSATANRGRSTRARGNNAAINEGVAQNTEFRRSAHLVSLHGTGPPKWTKDLLQQFYQNHLNRQCERQLSEQNVESSEWEAFKELQVPKLDDIKVEEKLKGLWRVEDTWVVEGECPVCRNNLPGGYGPPGTGIGGIIPLQARLSKNINSHKRKKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I6J4</accession>
    <name>A0A1B9I6J4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 10">Imidazoleglycerol-phosphate dehydratase</fullName>
            <ecNumber evidence="5 10">4.2.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_03204</name>
        <name evidence="12" type="ORF">I206_102852</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.19" evidence="5 10"/>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF51138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012357.1">
        <property type="nucleotide sequence ID" value="XM_019154954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I6J4"/>
    <dbReference type="STRING" id="1296096.A0A1B9I6J4"/>
    <dbReference type="GeneID" id="30171573"/>
    <dbReference type="KEGG" id="kpin:30171573"/>
    <dbReference type="OrthoDB" id="447729at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07914">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.40:FF:000004">
        <property type="entry name" value="Imidazoleglycerol-phosphate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.40:FF:000001">
        <property type="entry name" value="Imidazoleglycerol-phosphate dehydratase HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="entry name" value="Imidazole glycerol phosphate dehydratase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002111">
        <property type="entry name" value="PRK00951.2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002114">
        <property type="entry name" value="PRK00951.2-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133:SF2">
        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE HIS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00954">
        <property type="entry name" value="IGP_DEHYDRATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00955">
        <property type="entry name" value="IGP_DEHYDRATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCF51138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC68916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="202" mass="21893" checksum="7C6A07C7901B36AC" modified="2016-11-02" version="1">MSARTASVERKTSETEITCSIDLDHVPGVTTQTIDVSTGLGFLDHMFTALAKHGGMSLTLKCKGDLHIDDHHTAEDCALALGAAFKKALGERKGIKRYGFAYAPLDEALSRAVIDISSRPYFVCHLPFTREKIGDLSTEMVSHLLQSFAFEAGVTLHIDWIRGENNHHIAESAFKALALAIRMAITRTGGDDVPSTKGVLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I774</accession>
    <name>A0A1B9I774_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_02063</name>
        <name evidence="7" type="ORF">I206_104531</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012568.1">
        <property type="nucleotide sequence ID" value="XM_019153828.1"/>
    </dbReference>
    <dbReference type="STRING" id="1296096.A0A1B9I774"/>
    <dbReference type="GeneID" id="30170432"/>
    <dbReference type="KEGG" id="kpin:30170432"/>
    <dbReference type="OrthoDB" id="1562405at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019441">
        <property type="entry name" value="FMP27/BLTP2/Hobbit_GFWDK_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019415">
        <property type="entry name" value="FMP27_SW_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019449">
        <property type="entry name" value="FMP27_WPPW_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045167">
        <property type="entry name" value="Hobbit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678">
        <property type="entry name" value="ANTIGEN MLAA-22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678:SF6">
        <property type="entry name" value="BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10344">
        <property type="entry name" value="Hobbit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01214">
        <property type="entry name" value="Fmp27_GFWDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01215">
        <property type="entry name" value="Fmp27_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01216">
        <property type="entry name" value="Fmp27_WPPW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27 SW motif-containing RBG unit" evidence="4">
        <location>
            <begin position="1426"/>
            <end position="1525"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27/BLTP2/Hobbit GFWDK motif-containing RBG unit" evidence="3">
        <location>
            <begin position="1543"/>
            <end position="1696"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27 WPPW motif-containing RBG unit" evidence="5">
        <location>
            <begin position="1983"/>
            <end position="2427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1391"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1747"/>
            <end position="1775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2752"/>
            <end position="2833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2946"/>
            <end position="3123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1397"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1747"/>
            <end position="1764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2757"/>
            <end position="2769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2777"/>
            <end position="2789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2790"/>
            <end position="2807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2815"/>
            <end position="2825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2962"/>
            <end position="2972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2988"/>
            <end position="3004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="3014"/>
            <end position="3033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="3067"/>
            <end position="3076"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCF51349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC70580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="3123" mass="352313" checksum="533B4D228A425D86" modified="2016-11-02" version="1">MSQIDQKHIYIISTLVICTVLYNLDLSFTYKIPLYLGATILGACWTITRFCTKWFFYLILPFLFCQYYFLLPWVIRRYVPQARAARLSIVGAFRGFEWHSSKITARAENGAWRWGGRKDESAGYFIYRVEDVSLRMRNGSEKEFESNRPSQKYNSLPSSCRLPLLRFKQKLSAFIRSQKRIDGFLIRNCIWGIQVAIHYIPGFARLISLEFKNCRIILEDFENIELVFDEFSFGAMINFQGVVEGELGNQQCLVSPSPSPQPAYQEVMRQNPLCFSPISERGRPTFSPPTSPPWSPIISPTVSPPMSPNFGSLAVPDPLASAPSTPNRQERSTSRLADARRRASVLSSSTSATAGYVWNRVTGRLYGSVTGTASIVNIRLVQPKSSDQPNIPQTPSHASSFRSIQALLRHNHSTQAPITDNGPYETLVGISGRTKAALGLGFGPKKGLWGEDTLDGQFETGEVKGNVAALQNLLDLMKQKRGAELEKPAIPRGKTPHWSARDWKRTILRAIKSVNVDLQKLSLVHYLNSPSSLDNTEDCYNVSVDLTQLGIKVSAADASNNDRARNAFGTNSAPESKIRGVGFELNWESISLDCLAPNEKTDEKSQLFVIQNGVLDGFSSWRPAGWRREELLFSSDPNLALIVVRSEVGSVNTAVDLQLLHELGAAWQATHPHKEKAQKAVKQVQHQSQPDLPPRIRMAFDVGHISAHLADRLSENTTAIMVDSDGMHFGCFTTFSDLIGRRRDKASSRQACQDEETIRENREKYKDFNIALPPSELPPNTRRSTHRPQAVLYDDYSIALKGDAQINIEPLRIKIKISDDNFTELATIGRLHGTVQGDVYGRQTPADKIGRYETATFDWASLSSSIDLGIDEGIHIDLWKMEVIDTLIAMGKAHQQGSPVKSQPAAQAEKSILDRLPSGISARFSLGMINMFVGHEDINPHLRTQDGPPIRGTWIQTSAVFEYALYQHYAQALPWRHQLTAPMRAKLQLPEDITVQALAFASRYRADGGDAALTSLVVEDFVIQPIYNGEKFDMKGGTRQKLIMKSIPQQQAVNDQCHWGTQRIWARLKAVRDEELRESHDHNGSQENVPLRPLEQYIPKLGYSVPPIEVSGTDQAQRPCLRIRNSRLHLTIQRTRLNAPTESKITSRLDNVEIIGNYSHVYCILHTALALKKLLNGWKRPKNVSDTASTETRKPLNISIGVLVPNFTAHIAFPLKEQLFFYSSNISFTKPPTKGILINADQALMYVPSPTTIGEWEELGRIKKLSFTLSDPGKALEISPSLESIRVRVPHRYQMNGLILDINVTIKALKLLLRNFFKSSCNEFSTRHVSIPEEPKRLPTINLLVGYISLEAKDDPADTNLNLIWRAGFLEQAKRNNLEDAFAKKITLMNSSNSSSEDSLNGFPNSNGTGRAEPKLTKKATVDVEDARYRLDVYLASNWIRRMKAAKREQRRREALTLKPMHGCGPNIKLPINIVPSSQTAPLLRATMENVNLTVSNPGMSREEIIEYMGQVSSPFEPGAKFSLMVPLKINWTMSEAKFTLRDYPLPLLKIPPTDKETSIPSYSMKCDLIIAEEYANEDSTFYVPVEVLPDGCGGENYGGLTLDIAKTIMPVKMYGEPRFKINSTRTTEFTWGMSYQFAIQDFVKVIETFSHPPRDPSPKLGSFDKMRLICHLKPIVEFEGPVHLHLKGTFDPYLISGLGAGFALSWKGNTKFLINQPNEDREALQVVADSLLIAIPDLTALNDSAATGSSIHSDDSASPQTPMANGVDTDEPESSLIDRRYTKPCAKFVGGTKVGFGFGRERTCRPWNCEQGCGDTDDPLHRKCRIFDFLPHQKIILKSPEVVRREEKRLGRTVDSYEGFRSDYTHFSVSVIAPTKASVENDPQNEDPAHVNSLHCTPKAMHHFIRWYNLFHHITWLPTREGPTEGGDPGSLFIGSRKKSKKESKPLATIKYRFDLRPLYVSHIYPQVTRELWAQGKSESLGIKVRAGRILFDAHSRIQERTIWHEELKVLRNTPHKPLYAADVVADDLTIKGIRAHFVERVRLDAQKFEKLPRSTELPKESKVWFDLTDYIDADRKPLDEDPQVEIIDFGDCPHVYFCRRTNSKDLNLNPNSAPKNRKGIESSKFGFEKTHHCYLDEAESRTEVDKRVTEKRIMELQNRLDSYPTTNNAEYENDLMITQNAINLLKRYLINVERDNPDQYDESGRRTSPERLFQDTIEIQSPRLFYNDASRPLLWSYAYSVSDRRKEEYHVSHKSLREYRDNFRRRKQRYLQAMEDHEERSDSNVPEDMVGELARSVTEKPLDSVFKILNVDNDREPIDAAKLGLPDDVMLKPKLQISIFKPQIALRSDASENAIVLLAVQEATIKRFAVEDPESVDSVTTDVLTRSFATLKDVQAFYPTTEALNRERSSDSASRALDFVPLEIFLDARSQATDYDRILLRTDIAGSYDQFNRIRIPRQLKWPKAYNAAGDPIEHLRIHQDLMTIITPQIKLFATSKHYDALYTVITDLLSYSDPDHQHRAQAVKDFSRQFDSADRDANRLIIDIHTLQQTMRHLMELQRGYETNLERLEEAGKDELFKIRADLAEGYESLYTINALIANTLAKDDARAFLKNALRLDVRLREVSWRMLKDDCISSLAQVSIKNTLCSYSNNKNGSTDCALVLGDVSVNSLAPDAKYDGMIVSQDDSSSKKKVKPPFAKVYWSSYPPIGGIPVFPEVDVALASVRFGIEEKVGHQFVDYIFSDRIRRRREKAKKQSTISSNGNATKGSKSDKAETSSIRSTSTRGITQNSSTSTEDLSIPTTGNRNELYPLSRSRSQVSINSHNDPDTLSGFNNNDDARLMRERASVNRYFGRISFHRMNLTLSYTSDDSRKHGTFTMPDCVNFHFKAPDLVYTGKYWVPEEIFEHVKRDTKSAAFNQWSDILPQLWKNTSIFKSKKTLRSLTERTSKAVGVSLPSPLKTITTHTSTTTTNDKEEDNTGKMKSSKSENIISPTNSSTSHTSPLIIKRDTLDSNYSHSSSPSNGNGNRSLRSIKSISPGMKSDESTDEDDNSISGSNGKHKEKGFKGLLGKLNIGNKHHHHNNNSSDELARSKSRGGSIERIVQQSTPSLISRIRSKDNPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I784</accession>
    <name>A0A1B9I784_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_02106</name>
        <name evidence="3" type="ORF">I206_104571</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012611.1">
        <property type="nucleotide sequence ID" value="XM_019153871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I784"/>
    <dbReference type="GeneID" id="30170475"/>
    <dbReference type="KEGG" id="kpin:30170475"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF51392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC70620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="96" mass="10565" checksum="C154D1732B2F75B8" modified="2016-11-02" version="1">MTNANFSERTAESADSITMSERPDNTNNLESVRSAGSGIERAVRVTQRFLRRTGTETRDDACMFASWWERQREATTAPESGQASSSNANPSGGTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I900</accession>
    <name>A0A1B9I900_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Protein transporter SEC24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I206_01342</name>
        <name evidence="15" type="ORF">I206_103655</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="OCF52058.1"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="5"/>
            <end position="39"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="29"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
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            <begin position="29"/>
            <end position="38"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="12">
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I908</accession>
    <name>A0A1B9I908_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_01294</name>
        <name evidence="3" type="ORF">I206_103705</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="David-Palma M."/>
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                <person name="Bowers K."/>
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                <person name="Mohammad A.W."/>
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                <person name="Yurkov A.M."/>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="EMBL" id="OCF52276.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC69493.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="439" mass="48340" checksum="1FF0A851199BB9F6" modified="2016-11-02" version="1">MDGPNGPSPGNAFSTSHKVAFDRDSSITISSTDSLSNSSSNTPATSTSASDETMTSLLNSADRERQNGGLTLYTTLTIIEDILKSQNELAENNNARWQKHVEYTNDKLKELTQLIDKAREETNATSNNFKAYIDETVEKAFQNIMNGEPSIHTTNRDTPAQSGSSSKRRRSQSRGISREIQGLNYPFFSAKLTKEKEKEKEKATVLSALPSNACSANKCSASQGEKTDDGPSKSSSVTRKATDIIDMTIDEEDDLRLRSASPVEILNCDNSPTPRASMKKVKPLERVSMGHKNTECRSATLINNISSTSRSSGSGDSKKRTFTALSRSDRFMMDKNAGRAGISSYKKTEASSIIGKKQVGTSLNGLKRVRYLVKRSDHTVSEATWELAKNIPDFGEKVIDLDQNCLEANIDIREKFVLLPEAKMFWDEKGNRRVGFNAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I9T5</accession>
    <name>A0A1B9I9T5_9TREE</name>
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        <submittedName>
            <fullName evidence="8">Nucleolar protein 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_01594</name>
        <name evidence="9" type="ORF">I206_103402</name>
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    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
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        <text evidence="6">Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.</text>
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            <location evidence="1">Nucleolus</location>
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        <text evidence="2">Belongs to the NOP14 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="30169963"/>
    <dbReference type="KEGG" id="kpin:30169963"/>
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        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Nop14"/>
    </dbReference>
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        <property type="entry name" value="NOP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23183:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04147">
        <property type="entry name" value="Nop14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
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        </location>
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        </location>
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        </location>
    </feature>
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        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00024695"/>
        </source>
    </evidence>
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    </evidence>
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            <dbReference type="EMBL" id="OCF52306.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC69462.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="938" mass="105088" checksum="DDF46CC255A8D238" modified="2016-11-02" version="1">MAPSQLSQLKAALSTAGLNNKSYSKKDKKAYKKGGAREIDRAKKNDRLEEIRRSLNKFDERETKVKHDVGGRNLKGVTGRPSSSKQAGLEQRKKSLLPEHQLRDHTGTFRDRRFGENDPSLSLEDRMLERYTRERQRGQGKKGLFNIEDEDNGLDGFDEGFALGGLTHGGRSVMDLPGDDFDAQGFGENDDDDDNDKGRVDRRTVNKVHFGGFDGEEDEEELHERKKSKAEVMNEIIAKSKAHKYERQQEKEADDELRDALDDDLDDLRALLEESAPAGPAASNFASTSRQSASAAKAAIPEEDVDYDQVVRSLAFDSRAKPKNRTKTEEELALEEKEILEKAEAKRLRRMRGESVSDDEDGEGSRKKRKTDGKKPDADDLGDDYVEDDLLGPGVTLEDIEKLSVPSDQEADDDVEEDDSEEEHEEDEDGEDEDDDEMEDDEDSEMGSDIEDLDDEDIPELVEAGDDELEEVIVKKSKGKKAARGEKTKEIPFTFPCPTSIEEFEDIMEDLEDSALPIVVQRIRALHHPSLAAGNKEKLQEFLGVLMDYILILASRPVPPFELISALTPHVVALVKLNAITAASHFVDKLKLMQKNLTRGLAKGPSQKTSKTFPGCPELVLLRLIGSIWSTSDFSHPVVAPAVLLMGQYLGQSRIRSTSDLASGLFLCSILSQYESLSNRILPEAVNFVASSILSLLPRRKGFEVNTTYPDSKANDVNLYVDSSATAVPKQPVNLPEAINSAHADLSSEQVEQTKVDLLVVAFKLSQTFATLYSSLEAFIEIIEPLTKVIEGSRVAKLSQELKTIHASTYNSLIRSLKHSKASRRPLTLQSHKPIPIASYAPKFEENFAPDKRYDPDVERNATSKLKALYKKERKGAIRELRKDNRFLAGEKAREQAEKDKEYNNRMKKVEGSLNVERAEEKEMEREKQRERKRAGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IA68</accession>
    <name>A0A1B9IA68_9TREE</name>
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        <recommendedName>
            <fullName evidence="5">DNA binding protein Ncp1</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">I206_01633</name>
        <name evidence="3" type="ORF">I206_103361</name>
    </gene>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013563.1">
        <property type="nucleotide sequence ID" value="XM_019153402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IA68"/>
    <dbReference type="GeneID" id="30170002"/>
    <dbReference type="KEGG" id="kpin:30170002"/>
    <dbReference type="OrthoDB" id="3267800at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF52344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC69422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="514" mass="56439" checksum="E87C10C9F0D4C365" modified="2016-11-02" version="1">MAALEPQVDNTHHFGTNGNNSVEDHDYGLSEKAQNLDLNDRPASRATHRTSQTTQSNFANGGPAVVPGKFVEDYNDNPSNTREGGNEIGLGSALSSDPTDLKPEVDQDEENPQRPGFNSRASRSYVKPIPIVTTYEPELPEAASVKQRKTVAGSTKAPSTKRASSKAGSIRSNKAASVNGDHVRSPSVNGDHVRSPSVASVRRLPAQNEEHNGFHPGQIATHERQHELQGGNRVSLHDSGPISRDRSTTFEEPDLPQQRATSPTRPHSSFGYRPQPNLMSISEADRSESRNEQSRDLRAGVLNRSGTVLSRSGTYGRNGNLSRGANGGTIGSRKGAFGRGAGASVGTQPEEVLGRDDIHQRAELSERILDDATLRRLSTMEKKDAKRLAKVIKAEGKSEAKSVAGAIKELERLTKLQREAASAERKSQLRLSKWTRREHKARLRFLKEKEKYEKIEGELRNSENDYEERRDHASGLTAQVAEKTQSVDDLRAMRAADDREREVKLLALKNPAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IA92</accession>
    <name>A0A1B9IA92_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_01749</name>
        <name evidence="10" type="ORF">I206_103245</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013678.1">
        <property type="nucleotide sequence ID" value="XM_019153517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IA92"/>
    <dbReference type="STRING" id="1296096.A0A1B9IA92"/>
    <dbReference type="GeneID" id="30170118"/>
    <dbReference type="KEGG" id="kpin:30170118"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000044">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="8">
        <location>
            <begin position="23"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="596"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="611"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="631"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="671"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCF52459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC69307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="682" mass="76056" checksum="445C71270EB27FF3" modified="2016-11-02" version="1">MADAKLFTRGKAQELRDELRGANDKRDKGFLRKKTALKKIVANMTMGNDMSPLFPDVVQCMQIQVLEIKKMVYLYLVNYGRLRPEEVTSAIGGFLSDCADRNPLIRGLAIRTMSSIPLPPIVKALIDPLRHALQDQDPYVRKTAAIAVAKLYASEPGRKVVEREGFVGMLRDLLADHNPTVVANCVAALVEISERGDDIVLKLNGNVAGKLVAALGECSEWGQIYILDSLLSFVPQTHLEAEQLAERISVRLQHANSAVVLTTIKVVLYLMNYMEDEVLMRVLERKMGPPLVTLLSSGSEVQYVGLRNILLIIQRRPAILQNEVKVFFCKYNDPIYVKLAKLEIMYRLTREENVSEVLAELKEYASEVDVDFVRKAVRSIGRLAIKISSSSDQCIQTLLNLMSTKISYVVQEAIVVIKDIFRRYPNQYESIIATLCENLNVLDEPEAKSAMIWILGQYSDRIENSDELLEDFAFTFKEEPAEVQLALLTAVVKLFIRRPTAAQELLPKVLKLATEEAENPDLRDRGFMYWRLLTSNPTAARDIVLSDKPVISTETDRMDKGMLDQLLLQTGTLGSIYHKNPNTFIRTAKARYLPDSPALNSSSKRHLITPSGVSSTSIRSPPSLPARPISSIPTDTESPISPNGGSSDPYGQLSDLEFVNGGGAGYQTDIPRPRGADEDLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IAG3</accession>
    <name>A0A1B9IAG3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">GPN-loop GTPase 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_01848</name>
        <name evidence="10" type="ORF">I206_103148</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
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        <text evidence="6 8">Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimers with GPN1 or GPN2. Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the GPN-loop GTPase family.</text>
    </comment>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="Gpn"/>
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        <property type="entry name" value="Gpn3"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="GPN-LOOP GTPASE 3"/>
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    </dbReference>
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        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00014587"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00054449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061952"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF52556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC69211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="270" mass="30454" checksum="61404F3996A7FCBC" modified="2016-11-02" version="1">MRYAVLVTGPAGAGKSTFCSSLITHAQTIGRQVHLVNLDPAADKFEYEPTIDIRDLINLEDVMEELEFGPNGGLIYCFEYLLNNLDWIEDELGSYEDDYLIIDCPGQIELYTHIPLLPKLVQYLQTSLNFRISSTYLIDSQFMQDKNKFFAGVMSAMSCMLSLGTSMICLMSKMDLVKDEKGRTKREVGRYLDPDPTLLFDSPDSESNPKFNALNRAVVGLIEDQNIVSFLPLDVTSEDSVNTILSHIDNMMQYGEDEEPKVPKDMDEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IAW0</accession>
    <name>A0A1B9IAW0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein CPL1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_00002</name>
        <name evidence="4" type="ORF">I206_101322</name>
    </gene>
    <organism evidence="3">
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        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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            <taxon>Cryptococcaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF52706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC67414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <location>
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            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628470" description="Protein CPL1-like domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Protein CPL1-like" evidence="2">
        <location>
            <begin position="219"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF52706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC67414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="298" mass="32097" checksum="EEFEA44B44262C0E" modified="2016-11-02" version="1">MWGLYYTALLLVGFNCLRFARADNAFAGCFLVTPSGTTQVSGTFSSATACDAACPNNKHSFYQLSSQSCYCTDKYPAEGNFETGTADACSNSSYYDARITHTSFTWRPTCYSTAPSGLSFSSITGPDTCLKNCGTSLGATFYVSSVDGNYQCACGQPTSFGSTATCGPGTYFYYYHTAAQASQGLSRRRKIEEERKRGVHTYCPKGFTPCQIGETSGAYECIDTSAELESCGGCLHGSLNSPNATTGQDCTNIPATLGGVTCESGRCVAYKCRPGYDLTDQQCHLREEIRTKTKKRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IB81</accession>
    <name>A0A1B9IB81_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_00216</name>
        <name evidence="4" type="ORF">I206_101110</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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            <taxon>Cryptococcaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
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                <person name="Heitman J."/>
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                <person name="Gargeya S."/>
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                <person name="Dewar J."/>
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                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="Dromer F."/>
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                <person name="Gargeya S."/>
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                <person name="Dewar J."/>
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                <person name="Imamovic A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
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                <person name="Birren B."/>
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            <strain evidence="3">CBS 10737</strain>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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                <person name="Young S.K."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Dromer F."/>
                <person name="Young S.K."/>
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                <person name="Gargeya S."/>
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                <person name="Berlin A.M."/>
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                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
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                <person name="Hansen M."/>
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                <person name="Imamovic A."/>
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                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1B9IBD2_9TREE</name>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
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            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
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    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    <sequence length="364" mass="40275" checksum="CB9D357A69A8D088" modified="2016-11-02" version="1">MRFTKSAITALFVAVLATAAPAPVPAGGVGVRPNDTAPEYHTMTDFDFQSLNLALNQEWIELDLFNYGVRTFSVEDFAAAGINEEDISLIQFMANQEVGHATLLTNILSAYGRTPAKQCTYAYDFYTVRDFVNFCQRLTRWGESGVYGFLPHLDSRPSAQLLLQSISTEARQQMAFRQLAGAFPMPVYFETGISQAMSWSLLQKYLISCPAENPHIEWPIFPALNVTNDANLLVDGYNAAISHNRTSLTEPGRKVELTWEAPMGNVSYNGLYNTTIGGNVTDPTAPKYVAWISQLNATYTEFNQTGNYTGYTFQPGGVVYNNTDDGIVNGTMFIALTDSNPYVTPYNLSLLNDVIIAWGLYQAD</sequence>
</entry>
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    <name>A0A1B9IBQ3_9TREE</name>
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        <dbReference type="NCBI Taxonomy" id="1296096"/>
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    <reference evidence="16" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Roberts A."/>
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                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 13">
            <text>L-glutamate + NH4(+) + ATP = L-glutamine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homooctamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="4 13"/>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF52851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014070.1">
        <property type="nucleotide sequence ID" value="XM_019151932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IBQ3"/>
    <dbReference type="STRING" id="1296096.A0A1B9IBQ3"/>
    <dbReference type="GeneID" id="30168518"/>
    <dbReference type="KEGG" id="kpin:30168518"/>
    <dbReference type="OrthoDB" id="1936100at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.70:FF:000004">
        <property type="entry name" value="Glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000004">
        <property type="entry name" value="Glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050292">
        <property type="entry name" value="Glutamine_Synthetase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852">
        <property type="entry name" value="GLUTAMINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852:SF57">
        <property type="entry name" value="GLUTAMINE SYNTHETASE 2 CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51986">
        <property type="entry name" value="GS_BETA_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS beta-grasp" evidence="14">
        <location>
            <begin position="25"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="GS catalytic" evidence="15">
        <location>
            <begin position="111"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCF52851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="WWC67268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="358" mass="39581" checksum="A1DC4CDEB448EA24" modified="2016-11-02" version="1">MSDLIATKRVDLLAPYLALDQGSKIQAEYIWIDGEGGMRCKTMTLDKAPASVSDLKEWNFDGSSTGQAPGDNSDVFLRPVAFFKDPFRGGANILVLCECYDNDGTPNHSNYRASCKKVMDSAKEHEPWFGLEQEYTLFDADGQVFGWPKNGFPGPQGPYYCGVGAGKVFARDFIEAHYRACLYAGINISGINAEVMPAQWEFQVGPCEGIEMGDHLWMARFLLLRIGEEWGIKPSLHPKPLKGDWNGAGCHSNYSTKEMRTPGKGMAAIEDAIKKLEKKHLEHIAVYGEDNDQRLTGKHETASMTSFSAGIANRGASIRIPRHVGAQGYGYLEDRRPASNVDPYRVTSILVETTLLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IC25</accession>
    <name>A0A1B9IC25_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_00473</name>
        <name evidence="10" type="ORF">I206_100853</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014391.1">
        <property type="nucleotide sequence ID" value="XM_019152253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IC25"/>
    <dbReference type="STRING" id="1296096.A0A1B9IC25"/>
    <dbReference type="GeneID" id="30168842"/>
    <dbReference type="KEGG" id="kpin:30168842"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000058">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="8"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="786" mass="86379" checksum="89D3D756BA712C93" modified="2016-11-02" version="1">MAMAPPRKGENYELRQQLNSEYRDKRADAIKRVIANHTIGKDCSGLFPDVVKNMQTDDLEQKKLVYLYLMNYAKTQPELVILAVNTFVKDTADPNPLVRALAIRTMSILRAEKILDYLASPLSRCLKDENPYVRKTAALCVAKVFDLKPELCVEYGFVETLRDLIGDGNPMVVANAVAALADIYEASQNLPPTPPGSPGRSTSPPPSSKPNSELFIIDPPTLTKLLVALNECSEWGRIAILNTLSRYKAVDEKESEHICERVMPQFQHVNAAVVLGAVKVIMIHVKGVTREDLVKSLTRKMAPPLVTLISSPPEVQWVALRNINLLLQKRPDILANEMRVFFCKYNDPPYVKVEKLDIMVRLASEKNVDTLLGELKEYASEVDVEFVRKAVRAVGQVAIKIDEAAERCVSVLMELIETRVSYVVQEAVIVIKDIFRKYPHSYEGIIPVLCSNLEELDEPEAKASLIWIIGEYAEKIENADELLGTFLETFREESYPVQLQTLTAIVKLFLKKPDESQAIVQRVLQAATKDCDSADVRDRAYIYWRLLSSDPAAAKSVVLAIRPPISLPQTTVPPATLEELLSEVSSLASVYHKPAATFIGKGRLGAEEMQRRAMEPEEDNAREKALQTVVAGQQAENLLDFDSDDIEPTSANSTQNQSLSMFGNSSSNTGISSTTISNVAKSNNPLDELMDLFSTASMTTPQNAPQPIAPQSAFSGIQGLENSTSSSSATNNNNASYDAFAGLSGLSSPPPTIGNGSGSTSPNPPQQQQKPLQQTGGAQDDLLGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IDE1</accession>
    <name>A0A1B9IDE1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_01014</name>
        <name evidence="10" type="ORF">I206_100311</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
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    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC66409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014927.1">
        <property type="nucleotide sequence ID" value="XM_019152789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IDE1"/>
    <dbReference type="STRING" id="1296096.A0A1B9IDE1"/>
    <dbReference type="GeneID" id="30169383"/>
    <dbReference type="KEGG" id="kpin:30169383"/>
    <dbReference type="OrthoDB" id="2154091at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="274"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="58"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="623"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="739"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
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            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
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            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF53708.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC66409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IDV5</accession>
    <name>A0A1B9IDV5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_01195</name>
        <name evidence="9" type="ORF">I206_100132</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019015107.1">
        <property type="nucleotide sequence ID" value="XM_019152969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IDV5"/>
    <dbReference type="STRING" id="1296096.A0A1B9IDV5"/>
    <dbReference type="GeneID" id="30169564"/>
    <dbReference type="KEGG" id="kpin:30169564"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF29">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="24"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="70"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF53888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC66231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="907" mass="100644" checksum="C20895CFB977C9E6" modified="2016-11-02" version="1">MNPTPPYDDILEDETLAPLKRNHACLQCKKRKVKCDATKPTCAPCLRSHAHAVRSAHRNGTAQPVLTCTYAEGDSPEPEAGDESKARKKGLSANAGVKRQHVGQGKRDSPDEEKEILKARIAELEARLAMLTPPSSHSGIEPSLPLSSDAYDINGNMPFSQTFTTSTTGPAHVKPILEEIGNSNYTLPDVATIDSIPLPESLGDFSGLDDFFLVPKDWPKGLPLPFLLEHLVETFFNYVPQTSRMLHRSTLLARIKLPPTSPDFPFPGLLHAICASASGYTAWVNNLAPHLLEEAVQRHLALGLDLTTIDDFGLAQAHLAAKAVELTASICIMGSGPLIFQLVQSCILLSDAFFTKGFPMKGWIMGGHPARLLSVLELCNRQPRTIQHKQPFLKAPETDMEREERLITTWMAFVADAGYTLNSNWAPSMMISEVRCNLPTSYEDWCKIEGMKKNPQNAGSHDLYYSHPIEDSFIFVIKGCILMANVAQWLRNWQQREKEPDDELAGCKTEEFRTLNHRIETFSTSLPAALKNIFRYLDSKSMGFDANLLSIHLIPNIATCLLHEPFMQWQPYDPSTITVQRAYDNIMAVLHLIPSNLDITLILTPALAMSLCTIGHFISDFIKHADALKQTQTAMKYRADMRVLINLLDRYGQRHPLGNAFVHFLEQYTRSAEDIVPTDSSEMCKFNVKRVEYVSSAEESILENIEASYINKINNHAETSAQYGKSMINGNISAGPSRSGSISLSSSGISPNTMLSNLSNQPTPESITSTCYSSVGAEGCILDFDSTSSINLVNNNNNGNLSHNQNIQIQQDQINLPISQWDVQSTNKSVADRPAFDNWDKSFHTGFHIGRQPGEQLPMMTFLGNLGTEDSVQPVPIPVPVQNVSTEFENPQWKHNPFNIPGTNVHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IDZ6</accession>
    <name>A0A1B9IDZ6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="11">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I206_00950</name>
        <name evidence="16" type="ORF">I206_100375</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="11"/>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014863.1">
        <property type="nucleotide sequence ID" value="XM_019152725.1"/>
    </dbReference>
    <dbReference type="STRING" id="1296096.A0A1B9IDZ6"/>
    <dbReference type="GeneID" id="30169319"/>
    <dbReference type="KEGG" id="kpin:30169319"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001389">
        <property type="entry name" value="ATP-dependent DNA helicase RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000340">
        <property type="entry name" value="Bloom syndrome, RecQ helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018982">
        <property type="entry name" value="RQC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF153">
        <property type="entry name" value="RECQ-LIKE DNA HELICASE BLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09382">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00956">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="454"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="655"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="97"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="196"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="317"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="963"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1247"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="218"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="969"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1020"/>
            <end position="1040"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCF53644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="WWC66473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1281" mass="141437" checksum="97A57B44E2D956D5" modified="2016-11-02" version="1">MSTPRNNLHEIMARKQGGKTSPSSLNAIASSSKGDGAIRTPSIFKLAKPLISTNDHLSNMPGVKQSQIIPLSGPKSTLTPSSASNLELDISKRPVKTGNQLMTPSSTVGSPFFTDGKGKGKEMPSVRSSGDAKASKFASWTAEKLSAEYMRLMEERDELKDRKLAILSGEADDDGHEFIDDDIELLTRKINALKDERDVRRRNPQHSTFQPFHPLPPQSSGSTAVSDPQTKYPTPETNLSNRSRSTVEEWQGQRPKGLSSDDLEYPPLVHDRPGNFLSRSEQPQAGPSRIRRNPSAPRPPSHDDYDMAMAEAGFEEDAYPDPGEMLIPPSSPPPRAVTPPRSKRNSQSQPRPLSSKAKAKAMAEIEDLAIEEIFSSPIQSTSNLPPPRVEASQARAVFGGPGPSSSQAKSRAVQVPVQRSVQVEKTYAWTKEVETKLRHVFKLPKFRKHQKEAINETMAGKDVFVLMPTGGGKSLTYQLPAICSQGKTRGVTFVVSPLISLINDQSRHLCNLNIPAIAYTGDMTQKDKNLAHEELSRPEPYTRVVYVTPEMLTMGGHIKSILRNLLQKKRLARFVIDEAHCVSQWGHDFRSDYLKLGNLRTDYPGVPIMALTATAQNKVEEDIIRSLGIQGCSILRQSFNRPNLHYEVRPKTKKIISEIVGFVRTQGEKASGIIYCNSRDGCENLAKEMRDKHNLEAHHYHAGMSKGDRRKIQEGWQEHHFEIIVATVAFGMGIDKPDVRYVIHHSLPRSLEGYYQETGRAGRDGNPSTCILYYTFGDGKKVLNQIDQDQNLTRDQKERQKASMNEVLRYCANKADCRRAQVLSFFNETFDPQECNHGCDVCLGRDVNVFTSEDVTADAVNVIKMLQHFRHEDRITIVNAAECFKGVRGSSGKGLDANPLYAIGKDWSRAEAERLIQTLVIEGALEEFCVASAAGWTNAYLTLGKQAGKYLNGSKTLMMDFRQASPRKQAPKKVARKTGSKTQLGIDNYAQKVPNPISRKRSHQQILAEEAEFDNSPWGDTDEDEHYDPDDPIEIDDDDDGGHTEREDDVLPLEVKKRKTTARKEIGNSIVPKGATSISTVSSASRVKGVIEVDRSSSGSPVEVCLQALEKMRASVLSKNKNAPKLDDEMLQYIAATMPANEAALKDCEGMTSAHMKTWSTKIMGICVKHRPAYHAFEPGVAPLATVSARSASSESIPSKRSNAITQIQKYAFDPKSSTSKSTSAARTLTPMKSAVTLASSLTNNGKALNGQLPLHSGKASTNGIRPVLVPQKTNARKDKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IE94</accession>
    <name>A0A1B9IE94_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Las1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_01051</name>
        <name evidence="2" type="ORF">I206_100274</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014963.1">
        <property type="nucleotide sequence ID" value="XM_019152825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IE94"/>
    <dbReference type="STRING" id="1296096.A0A1B9IE94"/>
    <dbReference type="GeneID" id="30169420"/>
    <dbReference type="KEGG" id="kpin:30169420"/>
    <dbReference type="OrthoDB" id="10263222at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090730">
        <property type="term" value="C:Las1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007174">
        <property type="entry name" value="Las1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002:SF0">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04031">
        <property type="entry name" value="Las1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCF53744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC66373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="480" mass="54894" checksum="6E000D416801AF12" modified="2016-11-02" version="1">MKAPKRTPWASRSELEELYEMLFAPNADDTSRRRGLARMSIYISSPSCPTFIHLLHSLISVELLPYPPKSIEENQRSRMMIGMAIVRFINGLVDPLQNGPYARPISHLAATLSIPPSLISLRHRATHEDLPPLPLLHQSLLSCISYLHYYSFLPLISSSSSSNNIPSGIAEKLESDKRKIEGLTKKWKKITKSRLREKEVREEDQSAIELRKIKKLLQGFESGLIVDVLLSKGGIVPLAIEKRANFTSISPTIPSLKIWLPLLEHLQESSHPDFINQITSKILDILLNPESHVTDLNADAHDNEKVKEDIRTFRWELAVWLLHFWNTENNSTMTLQNDQKVDFIKRILRALLELHDDIVVRQLFKALQTFESSLKELGNLLPDINNQKEIEEVGLKGLEVDMEENLIDLRKMEVRLKQFDQILASRNSKIKTNQDNDRILHNTSSVHQLPQSDDNSPPGWRKLSDDIWKPCYIGCNGIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IEF3</accession>
    <name>A0A1B9IEF3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglycerate mutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_00966</name>
        <name evidence="2" type="ORF">I206_100359</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_019152741.1"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC66457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="31748" checksum="E0E8EA3A05E6BA9C" modified="2016-11-02" version="1">MVKYTYTHLDEFFVLSQWIEDVKGPFGLRPPPGDWASFKARIQALNDACPPGESVKVIYAARHGQAEHNALADKYGEGAQIKYPTLDPDLTTLGRSQAFETRLALQREIKRGMPVPSKWFVSPFKRAGETCGIEWGFMFSDEYEIDGGNYNGGKGHGVNATVIENIREHLHVHVCDKRCSISQLKSQFTSFNYSKDMIDEDLIWQPIEIRDRETEEELVARRGEGIREILEKSQGDTYISITAHSGTLRGIYKSLNVIPRKLVVGEMNILVIRVKELQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ8KXY5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_100409</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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            <taxon>Cryptococcaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
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                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_070202193.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="kpin:30169285"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MCP_dom_sf"/>
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        <property type="entry name" value="MCP_transmembrane"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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            <end position="100"/>
        </location>
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        <location>
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        </location>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="6">
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            <end position="111"/>
        </location>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC66507.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8KZ89</accession>
    <name>A0AAJ8KZ89_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
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    </gene>
    <organism evidence="7 8">
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        <lineage>
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            <taxon>Basidiomycota</taxon>
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        </lineage>
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    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Abouelleil A."/>
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                <person name="Berlin A.M."/>
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                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
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    <reference evidence="7" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="7">CBS 10737</strain>
        </source>
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    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
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        <property type="protein sequence ID" value="WWC66506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="kpin:96955688"/>
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        <property type="component" value="Chromosome 1"/>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <location>
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            <end position="150"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC66506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="150" mass="16561" checksum="82F11314E502D5F5" modified="2024-07-24" version="1">MLYLTPGLLATTFIHSLCVTLVARTMRVFFLGASAPEDISDSISPWRWAVFIIWQALATAWLTPLEVVSTRLSVQPNTPGAIATDEEESGPPEGVSFCGTDEDVIGLRPTTDPYLGLLDCGRKVIEEEGWQSLYRGFWWTMLSNVFGAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8KZK9</accession>
    <name>A0AAJ8KZK9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_101723</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058548.1">
        <property type="nucleotide sequence ID" value="XM_070202447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8KZK9"/>
    <dbReference type="GeneID" id="30174679"/>
    <dbReference type="KEGG" id="kpin:30174679"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283:SF3">
        <property type="entry name" value="BETA-LACTAMASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G07500)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="1">
        <location>
            <begin position="14"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC67809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="415" mass="46341" checksum="87F32ECE0D510257" modified="2024-07-24" version="1">MPVQLSENAREQLDQVLEAYPQPGKPGTVLGLVNKEGQLIYLKSVGSKNAVTGEKMEDDTIFWIASCTKMITGIAAMQLVERGLIDLDEPVSKFIPELADIHVITDSSETSVETRRASTSITLRMLLTHTSGWGYSWYNQHIFNWVKQNGNEVNGHGSWSELNNKTNEPLVNEPGTKWEYGINMDWAGIAVERVSGKKLGDYFIDNIFKPLEIDDSYFDFKDRPDLLERLSPMHKWDAEKDEYSIRDFPHLLVDTLNHRGGGGLHTTAGSYLKVASVLLNNGKGPNGAEILKPETIKLMFKDHCENIHDRGGLGTNAVVKSTDPSRASTDLEMLPGTKKGWGLSFLLNTEDIPNGRKAFSAEWGGVANLFWMADPKSEIAMCIFNDVLPYGFPEFFKVEEQLQQIVYAQGGLVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L0V3</accession>
    <name>A0AAJ8L0V3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sugar phosphate phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_101361</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>beta-D-fructose 1-phosphate + H2O = D-fructose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:35603"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:138881"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>beta-D-fructose 6-phosphate = dihydroxyacetone + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:28002"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="domain">
        <text evidence="7">Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="7"/>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008982.2">
        <property type="nucleotide sequence ID" value="XM_019158369.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L0V3"/>
    <dbReference type="GeneID" id="30175039"/>
    <dbReference type="KEGG" id="kpin:30175039"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.60:FF:000002">
        <property type="entry name" value="Protein-glutamate O-methyltransferase C1393.13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10880">
        <property type="entry name" value="Uncharacterised protein PF01937, DUF89, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036075">
        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039763">
        <property type="entry name" value="ARMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260:SF6">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01937">
        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="AF1104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Damage-control phosphatase ARMT1-like metal-binding" evidence="9">
        <location>
            <begin position="28"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="159"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC67453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="480" mass="55242" checksum="D620AC974BFF8569" modified="2024-07-24" version="1">MPFPDVFKLPYDRCSPKEKQGFAYVSLVKRWPVVLTNIVSAVSNVNHQLHMNPDEYSEAKINEGKKIISQISQMKYDLGHNAILTPIENDGDINRECYNDELKTYPDEDRRWGTMNWLYAECYMYRRLRSYFASTIYWKEYDPFFEQKSETYKSSSNAILHLTKSINQAIKDKEKLNENFEEKGSKLEIAFLEMIQADLWGNATDLSLLVDLNYKDLQKLQAVGSDSQKEQFKFILKNDLIKVWNYLKKLNTKQNGGRIDFILDNSGFELFTDLILADFLISCTPFINKVVFHPKAIPWFVSDVLPYDFTWAIDSLLDPSFFTSHSSTPISSEDLNSLSDLANRWKDHLKTGKFQLSVPEDTKLGKATPLGRIWTTQYAFQDLPEVAPGTLDELKKSDLVIFKGDLNYRKLVGDAWWPTTTPFEEALGPLAGKITLLSLRTNKADTIVGLEEGVAERLDKEDPDWRISGKYAVVSFSEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L1Z5</accession>
    <name>A0AAJ8L1Z5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Choline/carnitine acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_101413</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058484.1">
        <property type="nucleotide sequence ID" value="XM_070202383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L1Z5"/>
    <dbReference type="GeneID" id="30174986"/>
    <dbReference type="KEGG" id="kpin:30174986"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004092">
        <property type="term" value="F:carnitine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000019">
        <property type="entry name" value="Carnitine acetyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000025">
        <property type="entry name" value="Carnitine acetyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.70:FF:000003">
        <property type="entry name" value="Carnitine acetyl transferase FacC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.20">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042572">
        <property type="entry name" value="Carn_acyl_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF29">
        <property type="entry name" value="MITOCHONDRIAL CARNITINE O-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00439">
        <property type="entry name" value="ACYLTRANSF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="10">
        <location>
            <begin position="42"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="575"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="575"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="603"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC67505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="798" mass="88825" checksum="C72C79569A2DFB5D" modified="2024-07-24" version="1">MSSSTINDLLPSEITLTKLSNIPHEPKRSKSSALLTPNLPKLPIPPLKETLNKYLISLKELQTNEEHLKTKEIIKEFLKPNGEGEKWQKKLKEYSKDKDSYIEEFWYESYLSHSDSVVLSLNPFFVLSSDVTPRSDPQLSRAASLILSSLSFIHDLRNGYLQADTVRGIPLDMSQYGRLFGACRVPTDRGCRMEVHEESKHIVVLRRGQFYWFDCLDSKNRPIFTDREILSNLEAIVKDADRTPVHSVAANSVGILSTESRKIWSHLRSELIKSNKLNASCLSVVESALFVVCLDDAGPEDLAELCGNFLCGGYKLEGGVQTGTCTNRWYDKLQIIVCSNGEAGINFEHTGVDGHTVLRYAADVYTELVLLFAKTINPSTPSLFKSKQSPFCKSAKSPPKEEDGEEEFEFQPKKLEWKLTPDLLAGIRYAETRISDLICQNDSQALEFKGYGGDFIKRHGFSPDAFVQMAIQAAYYGLYGRVESTYEPAMTKAFLHGRTEAIRTVQPESVAFVKAFCSDHASVHDKIEALRKACKRHTQLTKECSQGLGQDRHLYAMYSLIQRDIQAYHASRARGSSATNGVSGKYNNGTEDSNGHSDDTGRISPNSQSAIAFSPQTQTSVLSGEGSAIDDVPIPDQKPRVPALFKDPAYNLLGTSVLSTSNCGNPALRLFGFGPVTPEGYGIGYIIKDEGISICMSSKHLQTRRLLQTLQAYLNEVQKMLIGLWKEANERPEAFMDHTGVMRDARTGKKVEMDGDEDKEEDGMLGGFGFFDVGVQAALPQARRRRPAVGKQLVIAEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L3U0</accession>
    <name>A0AAJ8L3U0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_102834</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012340.2">
        <property type="nucleotide sequence ID" value="XM_019154937.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L3U0"/>
    <dbReference type="GeneID" id="30171556"/>
    <dbReference type="KEGG" id="kpin:30171556"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03753">
        <property type="entry name" value="proteasome_alpha_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000015">
        <property type="entry name" value="Proteasome subunit alpha type-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033812">
        <property type="entry name" value="Proteasome_alpha_type_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC68898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="245" mass="26616" checksum="9BAAC69103BE6128" modified="2024-07-24" version="1">MFLTRSEYDRGVNTFSPEGRLFQVEYAMEAIKLGSTTVGITTPEGVVLAVEKRVPSPLLESSSIEKIMEIDSHIGTAMSGLTADARTMVEHARVTSQMHAFTYDEKIGVESCTQAVCDLALRFGESVEDDDALMSRPFGVALLIAGIDEKGPQLYHTDPSGTFVRYDAKAIGSGSDAAQQSLQDAFHKQMTLLEAHSLALKVLKQVMEEKLDENNVQLAQVTKAQGFEILGENDLKAVIDTLGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L438</accession>
    <name>A0AAJ8L438_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription factor IIIC 90kDa subunit N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_104189</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010931.2">
        <property type="nucleotide sequence ID" value="XM_019155973.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L438"/>
    <dbReference type="GeneID" id="30172605"/>
    <dbReference type="KEGG" id="kpin:30172605"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044230">
        <property type="entry name" value="GTF3C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024761">
        <property type="entry name" value="TFIIIC_delta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024764">
        <property type="entry name" value="TFIIIC_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15496:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15496">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 4 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12657">
        <property type="entry name" value="TFIIIC_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12660">
        <property type="entry name" value="zf-TFIIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor IIIC 90kDa subunit N-terminal" evidence="2">
        <location>
            <begin position="35"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor IIIC putative zinc-finger" evidence="3">
        <location>
            <begin position="730"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC70239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="841" mass="92563" checksum="4A44F0D9167BD103" modified="2024-07-24" version="1">MTVAPSSEDAVSPTILTSRTFPGIIPSTSHHNVSWNDDGQCLFLTKKGVNIVTPYLTTTLAPPPTLVDPSLSLENPSSVINESRRKAALAIGEDGSDDDGLDTFEEVPSGPEKQSKGKGKRRRPKAGEIKFWATGIEVDKDGKRNEYYGWNDIGDEISTVLTEREITTRQAIWSPSGLSDLGGSLLVVLSSSMQVSVYAPRNDPYTKQWDEIADLTSIIRGSLPSTSTHGGLSVEGNLEMRTMCLQWSSHLPLPSLIGVDGSILALGNRAGTVSFWNYGPEKHFRQLHYIQICEAGGWVSDMAWSEWNILDNMTCEAHLALSMTDGSIRITSIRRQVEADSLGKKRWNLEVQEPVLIDRGDKRFITSLRWVDDVLIWTKSGTVHIFAAEGNATVQWHGIVALRLKRVGNWASANALGPCVGIHRINRDTIIVVLSSLTSHIITDFAAAPRLAHPHESLRAALALRDMFEDHLLADPLIKMRYRSVELQTEGWTANTTGWTSLGWGGVGSWVTEPISFHTLDSATEGKRSMNFVLGNMGKAIPAADSTVFQALQAVLSDPPNLLLTSSGRVLLPYLLHINSLKQPESISEQLLTLLDSVPNNQAEARRDEQKELVQRFWSDRKLNGFRLAFVLASWCTTAFSSLTDNYQQLTNVISSSISACLLQSLLGWFTSDSSNTFLGNLDRQFIDQIIKAAHQLPGIVAGDQLSEMIADATRKLDQAEMGRKSDEGSEERCPACRTEVGSTGVCAKGHVWSRCSITQLLITHPHYRVCSTCPAISLLPKRHLASPVAVDEQGRDYDYQRFIQIDQSHPHSHGGDDLIQIALEAAIGCIKCGGRWQRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L4D3</accession>
    <name>A0AAJ8L4D3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_103052</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058774.1">
        <property type="nucleotide sequence ID" value="XM_070202673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L4D3"/>
    <dbReference type="GeneID" id="30170313"/>
    <dbReference type="KEGG" id="kpin:30170313"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="61"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC69116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="740" mass="83233" checksum="9ECF2EFD58EA351B" modified="2024-07-24" version="1">MSSVTPSDEVASGDISGRRNKRKVTHIAKACDRCRKRKIRCSGDDPCEECCEKEVDCVYENEDKRRTKNEMQDLKERLARLESLLEMQSYSAAVVDQELAETGPSVRSTIGRRVDTLKPAENIIDLVFDNPMADYTAPEISANQTMTSDIRHPPEARRPTRYSDIALSASQLDRLKATSGNGPSVQYGATSIWTHDNYEERTDIAETQLSARGSELLPGEFINWSQNLPPTLVAVINKNIHDRAIDQFVAYYASWCMILDSERFKADLLTCNISSINPQPAGSPSTRKWTSHYSPFLHNVVLWLGLHHNREIWPEAFQIFTECLVDHCTRLMRAEFEKATLSALRAVNLFGTCLAQPPNGSHDFGYTYYGMTVAMIQVLGLNINCEAYVLQGRMTRSELDSRNAAYWAAYMYDLLRSISAGRNPMISTPHPEISLPSISSEIDNAPWYLSPTAIAQETKLGHTLNGVKSMKSTCFHWTARLGCLLSKVVHSLYSTKIESDTTKGPIVEEISLNLDKWYNEQPFQDPKKLPLPHIVLSHMLYHLTRIFLFRPFYRSTFNDNTARMDPSPAEQCDKASKSILELLKLYDKYHGVRYGIGTFVNATFTSATIFLLRAVEDQSDPTVSANTNKQSRKNIEEITYYMSQLAITYVEAGRGLNILRSLCSEWLPTLNETSSTSATDANVDDQLQFNTNVITQNESDNSAVGGNVTGMTSMGYENFLNEFPSDEEFYNALLSFVGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L4E9</accession>
    <name>A0AAJ8L4E9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_103312</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058821.1">
        <property type="nucleotide sequence ID" value="XM_070202720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L4E9"/>
    <dbReference type="GeneID" id="30170051"/>
    <dbReference type="KEGG" id="kpin:30170051"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22927">
        <property type="entry name" value="HFD_SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037782">
        <property type="entry name" value="Spt7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47343">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47343:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="55"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="154"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="723"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="228"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="766"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="787"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="802"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC69373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="811" mass="88999" checksum="32E11A2ED8A5DBF7" modified="2024-07-24" version="1">MKYLLNFLEGIPDAPNLSDPEFQQLLADVQAGKSSHRSSADAFYDSLEKLVNELKSSPESLAFQKPVSKRDAPDYYEVIKKPMDLTTIIRNIKARKYKNKADFQSDLALIWENCYEYNSQETHPLRAAARFLKQKAEHHLVYLVDKNEKPANPLQGLLSQGISINGSPAPGSSGPSRGVGTRGESLLTVGGDEDAAGESDDGQNEEADFRDGGGPLDRGTQGGQAQRSRRDTSVASTSRRENGASRRSPPAFRPQLNTSLEAAPALVRTPYTMTHFSPVSLNQPGPSFSDKGKAKEILYGNAPPAWFPMPSSSTSGPGFEDEDLKLEGYWWGAMSASNEDSLIGGLPSIPQMVDLGSPPLRKRRIKRSSRTGTLSDGNGSLVISPGKKKKKINLKKIIDQTVNKLHDARNTIHRIQEFQRIEMEGGLLPSRELESEKEKLIKREERLERSLLRKEESGRSKQRKKEGGEIGQEEATLELKKASAGLLAHSGFEGANEMALDLFTRAAVDHISNMGRTLRLLIDGFSNKMSAEEIVLHALHENGQIETQDLEAHSKDDIERESIKVTEMQRKIRQAFKEVTTAPVIEDDMMFANNGEMLMDGNFADELGEDFLGLRDMGIDKEFGLSSLTVPSSLFYGRRRRLAAAHGEKEDLPDYPPPPPFIPLNPTTIPTHLPALLHAFYAARIESGLSILEDDVFDPSQGQIGSLGQIIVKTQSSQTAIPVGTAGLKKKRDREDGNAEDGEEAKKKAVKKLPVPGIGKGNWVRPSKEEKAKKLAEKAEKEGLSLPNGNNKPNGTANGGGIEEDAEGEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L574</accession>
    <name>A0AAJ8L574_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">OPT family small oligopeptide transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_103031</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058771.1">
        <property type="nucleotide sequence ID" value="XM_070202670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L574"/>
    <dbReference type="GeneID" id="30170333"/>
    <dbReference type="KEGG" id="kpin:30170333"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="473"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="557"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="601"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="627"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="669"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="709"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC69095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="759" mass="83266" checksum="204CE63065F9A4A4" modified="2024-07-24" version="1">MDQLAILNTTGQGPVPSLEGRQPIIDKGTLQPEDDKDLFVDPPDNANQQHLKDDISEDGHIIRTGRDAADHLLSIRDDGDPAITFRSLVLGTIMACFQASMNQIYLFKPTQVSISGSFIVVGKTMAGVGALPFWIKVIKIVNPSPWGLKEHAIAAITASAASGGAGAISVFTVQDLFYGIPLTATTVILSTLSIGLFGYGLTGLLRPITVWHVEAVYWTNIPTVKSLQILHWDTVKDSKPLRYFWYSFAGMTVYEFFPAYIFPWLNSVSIPCLASMKATGSKAAILTNLFGGALSNEGLGIFNISFDWQYITSGATSMPLKLQGNYLIGIIVCYIAFLAVYYGDAWGGRSLPFLSTSLRTASGGKYVSTKVFIDGVLDKEKLAEYGLPKITSTYVWAMIIGNAAIGGVIVHCTVFYGPDIWKALKNGRKGIYDDRHHDAMKRYKEAPWYWYVAILIFAFVLGLVVVIKEHITLSVGSYITALVLGSVIAPFSTILYSRYGNGIATNQLMKMVAGLTSPGRPIANLYFSSWSHSVISQSLNLACDLKMGEYLKIPPRAMWVTQVYGTVLGAFINYVVMISIVNSHRDLLTDSNSGSSVWSPAYFQSLNTSATTWALANYLYSRAGEYFIVPLGLAIGAGAVLLHRIFVIFVPRIGKISTSDFNLPQFFAYAGYLGFNQTQSCVIFSILFAGFFTQYYLRNYKPNFFKNYSYVITAAFDGGSLFVLFILSFTVFGAGGPEKPFPIWWGNSDGNPDHCPISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L5I8</accession>
    <name>A0AAJ8L5I8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_103492</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058878.1">
        <property type="nucleotide sequence ID" value="XM_070202777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L5I8"/>
    <dbReference type="GeneID" id="30169873"/>
    <dbReference type="KEGG" id="kpin:30169873"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09251">
        <property type="entry name" value="AP-2_Mu2_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14836">
        <property type="entry name" value="AP2_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000002">
        <property type="entry name" value="AP-2 complex subunit mu, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043532">
        <property type="entry name" value="AP2_Mu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043512">
        <property type="entry name" value="Mu2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="10">
        <location>
            <begin position="169"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC69550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="427" mass="48486" checksum="84833767893C6EBE" modified="2024-07-24" version="1">MISAFFIFNQKGEVLISRLFRQDLKRSISDVFRIQVISNPDVRSPIITLGSTSFFHVRINNVYVVGVTKCNASAALVFEFLYRFITISRSYFSKLDEESVKNNFVLIYELLDEIIDFGFPQNSEIDTLKMYITTESIKSEMAVREDSSKITIQATGATSWRRSDVKYRKNEAFVDVIETVNLLMSKEGAVLRADVDGQILMRAYLSGTPECKFGLNDKLVLQKRGNEGTKSDDAVELDDCQFHQCVRLGKFDSDRSISFIPPDGEFELMRYRSTSNINLPFRLQTHVTEPSKSRVEYTIHLKANFDSKLNANNVVLRIPTPLNTTGVQAKVGVGKAKYVPGENMIVWKIPRLQGAQECTLTAEADLAATTHRQAWSRPPIQVDFSVVMFTASGLLVRFLKVFEKSGYQSVKWVRYLSKANGSYQIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L5K8</accession>
    <name>A0AAJ8L5K8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_104463</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059057.1">
        <property type="nucleotide sequence ID" value="XM_070202956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L5K8"/>
    <dbReference type="GeneID" id="30172325"/>
    <dbReference type="KEGG" id="kpin:30172325"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="594"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC70512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1086" mass="119107" checksum="091D3C8A4CC393C9" modified="2024-07-24" version="1">MTLSYLVSTAGHAQYQNEQYPHDVENILQLINDGAKEFEQEKVVGFTSRTENAGWTCDCYSFPELLDLSSRLVGGLVSEGVNESKDNAGIVSLLCPTGLDFLLGWIALMRMGYGVVLIAPQCSPSAVAHLYKASASTKLIYHPKYTELAHSARQLDATVTSIPIPLGFNDLPPTDLTCAVHNNDSVSHIFHTSGTSGTPKPIPNTHSLSVSVLPRRALPSYSPSSSSTTKNALPSESAAFTTTPLFHGGISDLLRAWMARSMIYFYPTSDVPITTGNVVQAVAACLESPCPLLNRTLSKHQQEERANRFRVTSFLSVPYILSTLVQDPEGPGIQLLKNMDYVSTGGAPLDTTIGNMMVEKGIKLVSRLGSSECGFLLSSHRDYSTEKDWEWLRNDSPYADALVFEQLEGESTPGETRYEMVVTDRWLSKTKSNRGDGSYATGDLYRPHPTKKDVWKYAGRGDDVIVLSNGEKASPGPIESVLRSSSFFSDVLVVGSEQSQLGVLLFPREIPASSSLLGDIAPLIADANASSPSFAQITKDMCYVVNSTTKTLPKSSKGTIQRGVAYDVFREEIDQLYQERGGQVETAPKRSLVGITIAVERIVKDAVASRLKVDTLGVENDLFSWGVDSLMATRIRTSLQKQLNTGGTVLPNNVVFEKPTINSLSQFIFDLQEHKVVNGIDIEETYRLMESLVEKYGFFGMGQDTKHLDRKQDRGKVNGKTVLLTGGTGSLGSFLLNQFSQPSPNVIDNVICLVRAEDDDAAYKRTFEGLSKRGFGLDPTFKVKFLAADLVKPDLGLSPAVYKGLVDKLDIVIHAAWPVHFTSSLVSFENSIEGTRNLLDLVAKTEGGKLYFCSSLASVLGKTSPRYLEEPSHDPSTASPIGYSQSKWVTERICGLASESGVLKDRVHIVRVGQLCGDTQHGYWNEKEGWPLLIRTAEITGSLPLLQEKPSWLPVDLASRAIIDITTSDHPSSPLIYHVVHPNNLEWQTVLNGLHAAGLSFKRVKPQEWLNYVDASVNDLELNPSKQMLHMWTEAYGDASKSPPEIMVDISNSSIASSTIRNLPPVDEDQVKRMVCTWRSTGFLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L944</accession>
    <name>A0AAJ8L944_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cleavage and polyadenylation specificity factor subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_105312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer (via N- and C-terminus); binds RNA as homodimer. Component of the cleavage factor Im (CFIm) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Nudix hydrolase family. CPSF5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059198.1">
        <property type="nucleotide sequence ID" value="XM_070203097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L944"/>
    <dbReference type="GeneID" id="30172147"/>
    <dbReference type="KEGG" id="kpin:30172147"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18871">
        <property type="entry name" value="NUDIX_Cfim25_Nudt21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016706">
        <property type="entry name" value="Cleav_polyA_spec_factor_su5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13047">
        <property type="entry name" value="PRE-MRNA CLEAVAGE FACTOR IM, 25KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13869">
        <property type="entry name" value="NUDIX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017888">
        <property type="entry name" value="CPSF-25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR017888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC71357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="259" mass="29044" checksum="0A6362D98A6C8ACE" modified="2024-07-24" version="1">MSLESLTIYPLDGYSFIERESQPDEDNSVTARLKRLEDQNDESGTRRSVEAIMLVTSHGFPHVLVLQVANAFYKLPGGYLDPLETDSAGLIARLNEQLGVPFSPSGKSSNGKGQAISIEGVVDVQVDDISENLTRAVWVSPPGGDWKVGDLLTTWWRPNYDTFYYPYIPVHISQPKECKKLYLVELPKNKTFAVPVNMKLHAIPVYEFYDNAARYGPQFSGIPYVLSKYDIYNKESNGVEIDIKSEAKNDAKNGDQDQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L9K2</accession>
    <name>A0AAJ8L9K2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_105540</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011457.2">
        <property type="nucleotide sequence ID" value="XM_019155303.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L9K2"/>
    <dbReference type="GeneID" id="30171926"/>
    <dbReference type="KEGG" id="kpin:30171926"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="487"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="515"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="546"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="89"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC71582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="574" mass="63232" checksum="618A12B2B4C05839" modified="2024-07-24" version="1">MAEREPLTSGTGGEAQYGGVVTGQGRTRRQMNRMSTQEIRIKIRKMADLVSSEDLGDREFTDLTLYEKKSLLINRELDEMGMGKYQWCVFTLCGLGYFLDLGWAQAFGLVGGAIQQELGVPDSQIGALSTAFNFGLCIGAFGWGLLVDIVGRRWCFNFTCLFSTVFGLCFAAPSNYSLTCLLACLIGLGVGGNIPVDATITMEFLPTKDRYLLAALSTFQPIGTVAVSLLAFALIPKYSCDTSLKSCNISEAPCCSKSNNMGWRYTVLVLGFFTLVIFFLRFAVFRFRESPKYLLSKGHDAHALDILHSISKFNGSKPPTLTIEDLRALDAAEERQIDRPNRPQQNLLRRQTSTAQLAKQAAVGGFMKTFGHLGGMFKQRIYLWLFISLAIAYMSLFWSFALAGYFLPLILKAKGIDAEGSIEDTYRSYIWIYTPGITATLVAAWITGFSKFGRRWIMVISSALMGASLALYQLVNSRVANIGFNAMEYWFQSIYAALLYAYTPEAFPATFRGTTGGMLSTLGRIASIIAPIIGSTVYHGSNSPGVLWMAAAGAWISTLAIAFLPYDSNRKQNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LAJ8</accession>
    <name>A0AAJ8LAJ8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Anthranilate synthase component I</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_107210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC73244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059578.1">
        <property type="nucleotide sequence ID" value="XM_070203477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LAJ8"/>
    <dbReference type="GeneID" id="30173615"/>
    <dbReference type="KEGG" id="kpin:30173615"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="entry name" value="Anthranilate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="AMINOBENZOATE/ANTHRANILATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236:SF9">
        <property type="entry name" value="ANTHRANILATE SYNTHASE COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="ADC synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anthranilate synthase component I N-terminal" evidence="2">
        <location>
            <begin position="67"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="1">
        <location>
            <begin position="259"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC73244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="48515" checksum="D1DB59984DD0EACA" modified="2024-07-24" version="1">MVPTSPPAVPSLDELINLFATSSSSPATLAPPSASIFSTPLETSKPKHAVENLKPNLIPVFVEIPADLLTPVAAYLKIAKDSKYSFLLESVIGGENLARYSFVGADPIKTIRTGEGFDVEGDPLTALEKELAPYRYVKIPQIGTFTGGAVGFITYDSIVHFEPVTKPKNPLHNPFPGMPEAFFMLTSTNLIFDHIYQTVKIVSHVHLQDGTPPSQIPALYEEAVGRIETLRRKLMTPDVPLPPQGPVHLGYETTSNVGEEGYKAFVTKLKEHIVAGDIIQAVPSQRFTRKTDVHPFNVYRNLRRTNPSPYMYYLDCGETQLVGASPETLCHIKDRKLRNHAIAGTRKRGKDEEEDQALEADLLSDEKERSENLMLSDLARNDVHRVCKPESVKIDHLFRVERFSHVMHLTSQVSGILRDDQSRFQALRSILPAGTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LBD7</accession>
    <name>A0AAJ8LBD7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Choline kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_106115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059350.1">
        <property type="nucleotide sequence ID" value="XM_070203249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LBD7"/>
    <dbReference type="GeneID" id="30173308"/>
    <dbReference type="KEGG" id="kpin:30173308"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004103">
        <property type="term" value="F:choline kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05157">
        <property type="entry name" value="ETNK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF93">
        <property type="entry name" value="RE24176P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC72155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="513" mass="58098" checksum="688A999447677347" modified="2024-07-24" version="1">MISSQADKAKSSIALNPHTNFESPGQISPTASSSTTSLPHTATSTDSYFPNSSTGPIAPRLRKTSTSSFSKLSDFSLDPPLLDEEDRYAPAAEPELRMNSFKGIRHVALSVDASEWRHPVFKQKVLSILRRLVSGALTNAVFFVTYNPSPDPTSPSESPLLTPTMPASDPAHPPPLTPDQYPPTILFRVYGPSSDALISREEELRILYVLNTEYHFGPKMYGTFQNGRVEQFFPSRALTAAELRQPHIYRSVARRMRELHSVELKLIGYEHGRETEPMIWRCIEQWAASAESVLDTLASAGGKWEIWVEKFGLHRLRKEVEMYRRWIETEPGKGKGVVFAHNDTQYGNLLVLDGDLPPNQPEHHKYIVIDFEYSAPNPRGFDIANHFQEWQADYHHPTLSHCLLAHGPYPTLAERQDFYRAYLSIEMDGREEVVRRRKDVLSEKVDALEREVRIWSPASSALWCLWGIIQAEEQVEAIVAQKEGYVPEYDCLGYAEGRLDMFRDEAKQLGVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LBQ2</accession>
    <name>A0AAJ8LBQ2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP-dependent RNA helicase DBP2-A</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I206_106875</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC72911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059520.1">
        <property type="nucleotide sequence ID" value="XM_070203419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LBQ2"/>
    <dbReference type="GeneID" id="30173948"/>
    <dbReference type="KEGG" id="kpin:30173948"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17966">
        <property type="entry name" value="DEADc_DDX5_DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="121"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="152"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="355"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="504"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="10">
        <location>
            <begin position="121"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="WWC72911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="552" mass="58723" checksum="DA0D069D0DEF2CBE" modified="2024-07-24" version="1">MSYGGGSYGGGYGGGGGGGYGGGGGGGYGGGGGGGYGGGSYGNYSGGAGYGSYGGGGGDRMGNLGGGLQTIDWNHTNLTKFEKNFYVQDPRVTARTDAEINAFRAEKTMKIQGQNVPRPITTFEEAGFPDYILSEIRTMGFTAPSSIQCQAWPMALSGRDLVAVAETGSGKTISFALPAMVHINAQPLLAPGDGPIVLILAPTRELAVQIQAECSRFGKSSRIRNTAIYGGAPKGPQIRDLQRGVEICVATPGRLIDMLETGKTNLKRVTYLVMDEADRMLDMGFEPQIRKIVSQIRPDRQTLLFSATWPKEVQRLAMDFLHDFIQVNIGSMELTANHNVQQHVEICTDYDKRQKLLGHLEQISKENAKVIIFIATKRVADDLTKFLRMDGWPALAIHGDKQQAERDWVLAEFKAGRSPIMLATDVASRGLDVKDIGYVINYDFPNNCEDYIHRIGRTGRAGRKGVSYTYFTPDNSKQARELVQILRESKSEVTPELEQMAMYGGGGGGRGRGGGGRGRGGGRFGGGGGGGYGGGSGANSVGGGGGGYSSRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LCH6</accession>
    <name>A0AAJ8LCH6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_107650</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eS27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059659.1">
        <property type="nucleotide sequence ID" value="XM_070203558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LCH6"/>
    <dbReference type="GeneID" id="30174354"/>
    <dbReference type="KEGG" id="kpin:30174354"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.100:FF:000001">
        <property type="entry name" value="40S ribosomal protein S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.100">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00371">
        <property type="entry name" value="Ribosomal_eS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000592">
        <property type="entry name" value="Ribosomal_eS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023407">
        <property type="entry name" value="Ribosomal_eS27_Zn-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11594">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01667">
        <property type="entry name" value="Ribosomal_S27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01168">
        <property type="entry name" value="RIBOSOMAL_S27E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC73678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="83" mass="8984" checksum="F27816539FF97622" modified="2024-07-24" version="1">MVLAIDLLNRPADVQARTHKLKKVVPEPNSFFMDVKCPGCFAITTVFSHASTVVQCQGCATALCQPTGGKAKLTEGCSFRRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LDA2</accession>
    <name>A0AAJ8LDA2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding nuclear protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_107663</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the small GTPase superfamily. Ran family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059668.1">
        <property type="nucleotide sequence ID" value="XM_070203567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LDA2"/>
    <dbReference type="GeneID" id="30174368"/>
    <dbReference type="KEGG" id="kpin:30174368"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00877">
        <property type="entry name" value="Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000131">
        <property type="entry name" value="GTP-binding nuclear protein Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002041">
        <property type="entry name" value="Ran_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071:SF0">
        <property type="entry name" value="GTP-BINDING NUCLEAR PROTEIN RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071">
        <property type="entry name" value="RAN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00627">
        <property type="entry name" value="GTPRANTC4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51418">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC73691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="211" mass="23906" checksum="D591BB53D8F9761D" modified="2024-07-24" version="1">MENQATFKLVLCGDGGTTTFVKRHLTGEFEKKYIATLGVEVHPLTFHTNFGTICFNVWDTAGQEKFGGLRDGYYIQGQCGIIMFDVTSRITYKNVPNWHRDLERVCENIPIVLCGNKVDVKERKVKTGNVTFHRKKNLQYFEISAKSNYNFEKPFLWLARKLVGNQSLEFVAAPALAPPEVQVDQALIAKYEEELKQAANAPLPDEDDADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MLB4</accession>
    <name>A0AAJ8MLB4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Obg-like ATPase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_100252</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014985.2">
        <property type="nucleotide sequence ID" value="XM_019152847.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MLB4"/>
    <dbReference type="GeneID" id="30169442"/>
    <dbReference type="KEGG" id="kpin:30169442"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.300:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="entry name" value="TGS-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00944">
        <property type="entry name" value="YchF_OLA1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00092">
        <property type="entry name" value="redox-regulated ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF11">
        <property type="entry name" value="OBG-LIKE ATPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="23"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="5">
        <location>
            <begin position="312"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="32"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC66351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="397" mass="43714" checksum="658383EB284CE47C" modified="2024-07-24" version="1">MPPKGKKVEETKRVILGRPSNNLQIGIVGVPNVGKSSFFNTLSQTDLGKAANFPYATIDPEEARIPVPDERFDWLCSLYKPKSEVPAFLTCVDIAGLTAGASTGAGLGNAFLSHVRSVDGIFQVVRAFDDAEVIHVEGDVDPCRDMQIISTELRLKDIEWVEKGLEMAKKNARSAGGVSLADKAKKEEVAIVEKILKHLTEDNKDVRKGNWSNKEVDVINGLNLLTAKPITYLVNLSERDFVRKKNKWLPKIKAWIDENNPGDNLIPFSVALEERLVRMSDEEKVAEAETLGLGKNASALGKITTSGYTSLELIRYFTCGPDEVRAWTVRKGIKAPQAAGVIHSDFENKFICGEIMSYADLKEYGSEAAVKAAGKLRQQGKPYEIVDGDICYWKAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MLH8</accession>
    <name>A0AAJ8MLH8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_101778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058554.1">
        <property type="nucleotide sequence ID" value="XM_070202453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MLH8"/>
    <dbReference type="GeneID" id="30174619"/>
    <dbReference type="KEGG" id="kpin:30174619"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC67861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="154" mass="17206" checksum="CCFDC907E939FBE6" modified="2024-07-24" version="1">MPSEDEMSVKQLEEVLTGEIGKLNPAQKQSIFGGLPPEQFYGDSSQDAEEQLFNVKNLLRKIRIELAKGASTCISEYSHDHFTDGKAATSKPPSKKAPLKKSTPSWAVDGVSDRRHALKPATLTSLLCLSSWHKNGLINYESWREFMRARNSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MLK5</accession>
    <name>A0AAJ8MLK5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Synaptobrevin homolog YKT6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I206_100539</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058326.1">
        <property type="nucleotide sequence ID" value="XM_070202225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MLK5"/>
    <dbReference type="GeneID" id="30169156"/>
    <dbReference type="KEGG" id="kpin:30169156"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15867">
        <property type="entry name" value="R-SNARE_YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000020">
        <property type="entry name" value="synaptobrevin homolog YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045848">
        <property type="entry name" value="R-SNARE_YKT6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806:SF1">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Longin" evidence="11">
        <location>
            <begin position="8"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="173"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC66636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="233" mass="25206" checksum="47D1F53D209722B4" modified="2024-07-24" version="1">MKVYSLSLLSVTPTTPAQATLLGTSQDLSSFSFYQRSSVGEFMTFFTKTVAERTPANQPSSVEENNYKAHVFRTSGRQAGSPGMAAVMITDLEYPYRPAFSLLTKLLDEHTTLLNNLPSASAAPSFGSASANAFGGNPSQAAAGGLPPAQKGKLEGTLTGYLSKYQDPKQADTIMKVQKELDETKIVLHKTIESVLERGEKLDNLVERSNALSAQSKMFYKTAKKQNSCCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MMG3</accession>
    <name>A0AAJ8MMG3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I206_100946</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058399.1">
        <property type="nucleotide sequence ID" value="XM_070202298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MMG3"/>
    <dbReference type="GeneID" id="30168749"/>
    <dbReference type="KEGG" id="kpin:30168749"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14077">
        <property type="entry name" value="STKc_Kin1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000958">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02149">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="165"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="KA1" evidence="13">
        <location>
            <begin position="993"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="45"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="109"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="502"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="611"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="905"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="508"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="703"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="759"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="779"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="905"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="916"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="929"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="952"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WWC67039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1042" mass="114218" checksum="53AECB4FE87CAA63" modified="2024-07-24" version="1">MTSFNPLPAHVQAAQDTFSSDGIPTPTYMGMVDTGAQWDYIIGKDGRRSRTPSRSPHRSATEPSVHRPSSLSHSQTLDPPVPLGSSFPSTSAHPQEPTINEEAAAVVSRSMNAQHYQQQLSNGESLAPNGHGGSTANGNGFNAAAGGSASASRSGRSKTRIVGDWQLGKTLGAGSMGKVKLAVNVVTKEKCAVKIIPRYTEATRREEPKTPEEAEKQRQRDESKEIRTIREAHISLLLHHPYICGMREFISHQNHHYMVFEFIDGGQMLDYIISHGRLRERAARKFARQIGSALDYCHRNSIVHRDLKIENILISKNGNIKIIDFGLSNLYAPSKHLSTFCGSLYFAAPELLNAKAYTGPEVDVWSFGIVLYVLVCGKVPFDDQSMPALHAKIKRGACEYPAWLSADCKHLLSRMLVTNPLERANLTEVLSHPFLTKGYDGPPDSCLIHREPLRAEEIDWEIVNMMQGFTFGSSEQIYDDLHSVLTSDSYLSCVAQYEARKDRRKGPTMSSSSMDVTNVTESPKKKRFSGFDFAKKKLFKEEKKVEEPVVKEKEPLDPTRGFDPLISIYFLAREKVERERVYGKGHFASSNMSIDGNDNTGYGRQVAQLQAPPSSHAMGGAYETPRDSGYLPQPRQRTEEVPNPVMQHPRADQEQSNIADLPHAHQRQPSLSQPPLPSQSLQPSPIPDQESLTKKFSLLGRGPRPSSSIPPSRSSSTATPPSQGMTPSPSMPLTAGGDHRRATTVSDKSNKHERRVSVGSISNISSTVGRATGLGRRSSQRERKATPTEHEPSWLNTPKEADEYHPAQSSVHAEDTNLEPDLQSEVGANAIHETHQNGDVKSVYLKGLFSVSTTSTKPAAQLIKDVSTVLNRLGIKHRPIRGGFECVHIPSIDLNSVVNGDEANTSLHSVNQSSGTKRKPSLRRKSSKANVNGSNSRNASPAPQKVLGTGSSGTFSMGDTPSTPGKRSTPGQGGAPPAEEDELDAWALAQSGGAGSSLIVRFEIFVVKVSWMPLHGIQFRRVGGDGWQYQMLAKTILREMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MNR9</accession>
    <name>A0AAJ8MNR9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_102076</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC68153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058601.1">
        <property type="nucleotide sequence ID" value="XM_070202500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MNR9"/>
    <dbReference type="GeneID" id="30175200"/>
    <dbReference type="KEGG" id="kpin:30175200"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051176">
        <property type="entry name" value="Cent_Immune-Sig_Mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 170 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715:SF37">
        <property type="entry name" value="LD47843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="775"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="4">
        <location>
            <begin position="56"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="179"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="351"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="563"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="389"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="563"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="573"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="613"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="656"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="704"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="728"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC68153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="801" mass="88314" checksum="646A82C8CEDF5B9F" modified="2024-07-24" version="1">MLQHPSQSYLNQGSGGQGGQSNGNVPWGGPFPSLHLWPLQDTFVMKMIHLPDGQRIKIGRQTNTKTVPGERNAYFDSKVLSRLHAEIWEQGGKIFIKDVRSSNGTFINGERLSPESVESEPFELKNEDQVEFGIDIVSEDNRTIVHHKVAAKVYCVFGPEDAALSARELVNYQNQDTRGVRRMPPQQNGHANNQLSQMGPSIMSSGGKSSGLSFDHVLTKLQNELRASKETGAELQTLATTFTDIQDTLGGGLPPSQNGSATQYIPPQFRSASAEAQAALAGPHGQQAAAFIALQNQLTETQASLGSQLEKIRLLEGQLKEHESIQSEISTMKEQIEESKREVSLLLASGGSILGGSHRGRQLTRRNEDDDDDDDDARSVMTMMDNEEAEQRVRDRRRIERDSPESRRDRDRTNGVDRPRTPEPTNVNGDRDSDEDQLSASSSSSSSYPNGINTISSTRETEIIEQNAELVGKIATLSAEIQEAVTLSQTLQSQHSEAMSAVRLLTERVGVLENGIASKVAEEVEKAESKWESWKVKFEEGWRKERESWDSERERLRGVVREWEEASRRAHEEEEERELNESLSEDESEEEEDGNEDESNQILSLDGWKGGNDATSSNSSKLPGLNGNNPGSRKSRRRKSSQKAILAVQALKDLSDPISSSSSNDKDNNNGSSTPKSSTTHILPSVNGNSSSSGLNNGGGSIRIKNRKRGQSKRSHNLARSGLSRTIQLDEKEKEHSNSSESGRESVSTLKDSDETDVAKTSNGKTKSKEIEGQVIRPVPVFTVLVVLVAAGVYWHKFHKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MP60</accession>
    <name>A0AAJ8MP60_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_102210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058628.1">
        <property type="nucleotide sequence ID" value="XM_070202527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MP60"/>
    <dbReference type="GeneID" id="30175947"/>
    <dbReference type="KEGG" id="kpin:30175947"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042483079" evidence="1">
        <location>
            <begin position="19"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC68287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="235" mass="24097" checksum="5C7648C1F4857CB2" modified="2024-07-24" version="1">MVVQSLITLALVASMGMALPQWGNWRAPATSSSSTSLVSSLPTAASLSTSVSQAGPASAVLPASTASSASVLPAEGSNSAEGAESHMITINNNCGGGTPMIAYAANRAGQAVQGSVTVNGMVDSGIAWMSGTKDNCGFDGTGCGFMEFTLANSIMNSGDYSLLTADLGNHDFKYAMDFHFTGQCSDGPGKSGAQIDLSLENSSRWAELRAKQRAGQIADGNVEEEGFNDQAFMDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MP78</accession>
    <name>A0AAJ8MP78_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_104753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059097.1">
        <property type="nucleotide sequence ID" value="XM_070202996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MP78"/>
    <dbReference type="GeneID" id="30170660"/>
    <dbReference type="KEGG" id="kpin:30170660"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC70801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="481" mass="53371" checksum="C8277B20755E57EB" modified="2024-07-24" version="1">MPDPIPAPQVDLYEPPDATPYLMPERQYSSTELRERHPPHRVDHMQNLSSSTHLLAPPVQGHAGRASPSSASDLRVLNQQGLPSSHTGRGSSPTSSQQRLNNHSNPPHISREIPTSIADCQDGLEPRDRSNASSNHATAIEQGSRQRSATSNTPVDSSQLTQPSSRTTINLSNNTVTRAAHPSRVRATNSSSNFHVNNPDQATTQASRHSNNNQARVPSSNTNASSGNMLTPPPGSPPPSYSQVGRDIIAQSSDHHHQNTVGIEQTLFSAPDREASDDEDFITNYDLTCSQCNYIYKCVGSSWDSVGNCPTHRWTRAIPHGCTSIQGAKPQGETDYRYACESCGRISNRLQNNTFYKMRCKECRNRVKSLILNPKHSATKKARLYCCSKPKCRAQTQGPIQHYCKKLNEWRKKYESYCRVDAKMVLIIPVEFKRDPIYVCAHCKVGFGAQRIGKLCPSCIAELTEQEARRLNCKIVQSTFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MPC3</accession>
    <name>A0AAJ8MPC3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">P/Homo B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">I206_102426</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S8 family. Furin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058660.1">
        <property type="nucleotide sequence ID" value="XM_070202559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MPC3"/>
    <dbReference type="GeneID" id="30171143"/>
    <dbReference type="KEGG" id="kpin:30171143"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007323">
        <property type="term" value="P:peptide pheromone maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04059">
        <property type="entry name" value="Peptidases_S8_Protein_convertases_Kexins_Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000026">
        <property type="entry name" value="proprotein convertase subtilisin/kexin type 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000005">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034182">
        <property type="entry name" value="Kexin/furin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF14">
        <property type="entry name" value="NEUROENDOCRINE CONVERTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 14 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 14 15" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 18" id="KW-0732">Signal</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042492432" description="P/Homo B domain-containing protein" evidence="18">
        <location>
            <begin position="23"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="769"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="P/Homo B" evidence="19">
        <location>
            <begin position="525"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="498"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="675"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="831"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="500"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="683"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="724"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="735"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="833"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="882"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="WWC68497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="940" mass="102613" checksum="D794DCE5F3FC2930" modified="2024-07-24" version="1">MLVISPLWSLLFSLLLINPSQAELRPRTPQPRSYDTHTYYALELDPSATKSAASSISNELGVELIEQIGELDGHWLVRKEGSTSNHFKRDISKDPILKRWDDLSSSRISSGRRSLTPLNVKQRSKRLHLPFRNSHLTSRDDTAELLYAQNELQLQDPMLDQQWHLINTEMKEVELNVTGLWGRGITGEGVHVVIVDDGLDLNSDDLKDNFFPEGSYDFNDHTELPLPRLSDDQHGTRCAGEIAAVPNDVCGVGVSYRAKIAGVRILSAPISDADEAAALNYGYQLNDIYSCSWGPPDDGKSMEAPEGVILKALVNGIHKGRDGKGSIFVFAAGNGGGADDQCNFDGYTNSIFSVTVGAVDRKGLHPYYSEMCSAIMFVAPSSGSGDHIHTTDVGQNKCAHSHGGTSAAAPLASGVFALALSVRPDLTWRDLQHISVRTSVHFNKDDPDWEKTASGRLFSYKYGYGRLDAGLFVEAAEQWKLVKPQAWFDSPAIYLPTTDGPATTPANPSRRQDDSVVASPDEGSTLPDQEDNMNGTKPNPPPVVIPTGSFITEDGITSTYEITKDMLKDANLEKLEHITVRVWIDHQRRGDVEAEIVSPNGVTSVLARPRRFDDANTGFAGWKFMSLKHWEENPVGTWTIKVKDANNPEKTGRFIAWSLQLWGETIDASKAKLWQPAEEGQPDQEQTGSDPSATTTQKPKPTDLLPGNHGDVTGEATKPGLVSTTQQAPQPTTTDDAEEDITEPTGITDEDADEGFFSGITTLSKNSTWIAGAGMIILLTGVGIGAFFYYRSRKRRQNLFGLSNNGEGARGAYAPVSEDVPMGLLERSRKKFGGGVKTTGGTGTGSKELYDAFGDGPSDSESEEDERTGLRYHDDFLEDEDHPPRISESDSKLKIEYKDEPEIESPGSGSEEKGKSKEITNTSASGSSSSWQDAAEDVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MPQ2</accession>
    <name>A0AAJ8MPQ2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_103272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
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        </source>
    </evidence>
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    </evidence>
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        </source>
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    <sequence length="355" mass="38394" checksum="F9C21AB3A63D08AF" modified="2024-07-24" version="1">MDIAITSSPISIHTHVNAVRPGPSYVNYARPPASAGVGRGRGRGRGRGAAAAAARNASQYQQRQVTPPFVYLQRPNGPNGNIANGTSPTSSDSSILPPNHIHIVQSQPTSQMNRTNSTFSLASVPPLSNGPSSTEGSFGELESYHTSPYQIYQPSTLIKEVEPDVEIIESHIESGYAIQAINHFADTLRGMQRATFDEWVTFVDSHFESSARFQLNISGAGLKSLDVSTLSLPRFFLTLAEEDTGNLHNLILSDLSEPLIGIVESGSVEWTCGDQHLKGSLTAELGLGEEYKLIRIELNLEAVEGTISGIPDNALRLLEIAQQMECMTEVLDIVDSENLDPNDALKQLEEQNGSV</sequence>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
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                <person name="Dewar J."/>
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                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="5">CBS 10737</strain>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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            <strain evidence="5">CBS 10737</strain>
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</entry>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
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                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
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        <source>
            <dbReference type="EMBL" id="WWC69424.1"/>
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    </evidence>
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</entry>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
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                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="McCowan C."/>
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                <person name="Pearson M."/>
                <person name="Priest M."/>
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                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
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                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
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        <text evidence="1">Belongs to the rtf2 family.</text>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Rtf2_RING-finger"/>
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    <dbReference type="PANTHER" id="PTHR12775">
        <property type="entry name" value="PROTEIN C20ORF43 HOMOLOG"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR12775:SF0">
        <property type="entry name" value="REPLICATION TERMINATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04641">
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        <property type="match status" value="1"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="20"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <end position="329"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
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            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="35563" checksum="FC68787EC16F51E5" modified="2024-07-24" version="1">MGADGGSIPDRRDLVRTKAQAGTTDKSLLRELYVLCALSKKPLNRPVVTDPLGKLYNKDAILEYFIDKSKYGDGEQICGHLKGIKDLINLNLTPNPEYAPPTATAVSQYTKTPFICPLSMREMSGVIPFIAIKSCGCVFSDAAIRGIIPNLTKGITAKTIENELTPEQPKSVISEGDNKEIACPNCGKSFDPRPTSAILPINPPKETQDLLLENLLIARASAKSSKKRKNAEKIDGDSIGKPVTKASKISAEDGKSPIPRVNSPSISANSNGGSGMPRSVQEKLAEQERKRLKAQEGMSEAVKAMFKPKNEGKKSGADEFFGRTFTRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MRJ1</accession>
    <name>A0AAJ8MRJ1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I206_105207</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011778.2">
        <property type="nucleotide sequence ID" value="XM_019155624.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MRJ1"/>
    <dbReference type="GeneID" id="30172253"/>
    <dbReference type="KEGG" id="kpin:30172253"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22948">
        <property type="entry name" value="Coatomer_WDAD_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000002">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000010">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047312">
        <property type="entry name" value="Coatomer_alpha_WD-assoc_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016391">
        <property type="entry name" value="Coatomer_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010714">
        <property type="entry name" value="Coatomer_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF1">
        <property type="entry name" value="COATOMER SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06957">
        <property type="entry name" value="COPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003354">
        <property type="entry name" value="Coatomer_alpha_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <keyword evidence="4 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="7"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="49"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="91"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="133"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="208"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="252"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="13">
        <location>
            <begin position="347"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="15">
        <location>
            <begin position="621"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer alpha subunit C-terminal" evidence="14">
        <location>
            <begin position="855"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="794"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="895"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="895"/>
            <end position="909"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR003354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF06957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="WWC71254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1225" mass="136734" checksum="04A54AB5353D986B" modified="2024-07-24" version="1">MQMLTKFESKSPRVKGIAFHPKTPLLAASLHNGTIQLWNYQMGTLVDRYDEHDGPVRGICFHPTQPIFCSGGDDYKIKVWNYKQRKCLFTLTGHLDYVRTVFFHREYPWIISASDDQTIRIWNWQSRTCIAILTGHNHYIMCAQFHPWDDLVVSASMDLTVRVWDISGLRKKNQASQAPMSFEEQVSRANQNQADLFGNTDAVVKYVLEGHDRGVNWASFHPTLPLIVSCGDDRQVKLWRMSETKAWEVDSCRGHFNNVSMSMFHPRHELLLSASEDKTIRVWDMTKRTAVQTFRREQDRFWVLTAHPELNLFAAGHDNGLIVFKLERERPAFSLSGNQLFYVKDKIIRMADLAAGTNQGICSVRKLGSQWIQPRTLSYNPAERAVVVTSPSENGTYELITLPKSSAPSASDGKDVPSDGKKGNGACAIFVARNRLAVLDKATQNIEIKDLSNSITKTVKCPVQTNEIFYGGTASLLLATPTSVVLFDIQQQKVLAEISTPPVKYVVWSTDGNMAALLSKHTITIANKALTQSALIHETIRIKSAAWDDSGILIYTTLNHIKYALPQGDNGIIKTLEQPVYLTRVKGQIVHCLDRTAKPRTITIDPTEYRFKLALVRKNYDEVLQIIRSSNLVGQSIIGYLQKKGYPEIALHFVQDQQTRFDLAIECGNLQVALEMARAVDREDVWNRLGAAALQQGNHSIVETAYQKTKNFDKLSFLYLITGNTQKLSMMQVIAQKRGDNMSRFQNSLYLGDIQARVEVLRETGQYPLAYYTAKTNGLDDTALEILEEAGMTEDDLPAPPQSSGHSSLAPPPISFPQSDSNWPIKNLGESFFDRALANGGVDESLGEPSGVESGEQLDAWAADVAIDGGADEGAEEGDEDEGWDLDAEVIAPPEEEITPEEEAGEADLSEGVTPGIPEDELWIRNSPLAADHAAAGNFESAMQLLNRQIGAVNFGPLKPFFLQSYQSAHVYVPANPSLPPIKYNVRRNPESTELREFLPVITYNFDDLKANELAEANKFFARGKFLEALGAFRAVLQKLIMVVVDDENEANEIKELVILCREYIIGLTMEVERRRLVAEEPESVVRNLELAAYFTHCKLATQHVQLALRSAMKVFSDAGNHATAAVFARRLIDTKPSGAQVITQARAVLAQGDRNPRDNNEIEYDQFTSFEICPSSLTPIYKGSPSILSPYTSSKYLPEFKGTICKIDEITQVGLTASGLRNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MST8</accession>
    <name>A0AAJ8MST8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Elongator complex protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I206_107112</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ELP1/IKA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC73146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059551.1">
        <property type="nucleotide sequence ID" value="XM_070203450.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30173713"/>
    <dbReference type="KEGG" id="kpin:30173713"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056167">
        <property type="entry name" value="A-sol_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056164">
        <property type="entry name" value="Beta-prop_ELP1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056165">
        <property type="entry name" value="Beta-prop_ELP1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006849">
        <property type="entry name" value="Elp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056169">
        <property type="entry name" value="HB_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056166">
        <property type="entry name" value="TPR_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23925">
        <property type="entry name" value="A-sol_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04762">
        <property type="entry name" value="Beta-prop_ELP1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23797">
        <property type="entry name" value="Beta-prop_ELP1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23936">
        <property type="entry name" value="HB_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23878">
        <property type="entry name" value="TPR_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017233">
        <property type="entry name" value="IKAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="ELP1 first N-terminal beta-propeller" evidence="8">
        <location>
            <begin position="18"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 N-terminal second beta-propeller" evidence="9">
        <location>
            <begin position="427"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 alpha-solenoid" evidence="11">
        <location>
            <begin position="721"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 TPR" evidence="10">
        <location>
            <begin position="926"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 three-helical bundle" evidence="12">
        <location>
            <begin position="1097"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1111"/>
            <end position="1138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC73146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1324" mass="147535" checksum="2AC184089D3EC58F" modified="2024-07-24" version="1">MRSLTPLGIQISSLDQFSSKVGNIAINPEDGTIFITLERAGEDGGVEIDILQITSDNTEPEIIASFSSPVLAPFPKPEHQGETLDIHYLPDDRTLIVLLAGGDIATLALEGSDGQISPVEIVGSVDSGIKAAAWAPDDEQIILVTGEDNLVCMTRHFDVIHEEPLRSDEFGEDGFINVGWGSKQTQFHGSLGKSAAKQPINTSKSISHPTDSGLPYITFRGDASYFAISSLDPYGGESSESRRQIRIFSRDPNTGFIPKLSSTSESLPGLEGNLSWRPVGNLLSTLIRYGYEGGGEGREGKWDIAMLERNGLRHGGFELRESKETWKDGKVKGLSWNSDSEVLAIWIERKDRDVVQLWSMKNYHYYLKQELFSHDPSSSRFSGFRWHPEDPLTIYLFGESFVQARTFVWDTYTARLPMPNDTASVAVVDGQKLLITPFRTQNTPPPMSSYHLDLPSVPVHVSLSDSTDSLSILFADGLVQVWDLNTRLPDPKLGSRLRGGGKVAEPKLKHSTTVSSAEKNLVKQIAIGPNGKVAILSWSEKDGSAKTLISIVEEKEETETEELEDDIERLLWAGEELLALTAQGQLKSVVSDQSIDITLGPHPTALTYSASSELIFALSPNSKLHLSSISPSSISTSIASNVTSYTLTPDFLIYTTSSQSSHYAPLPTLGRLANGDDLSTQEMTWDERRVERGSLIVAACESSMSLVLQMPRGNLETVYPRALVLAVVKQDVLSGNYRNAFLQCRKHRLDLNVLYDLDPLQFMKNLKNFVEQVPEVDYLNLFVSSLSSADSAKVLYGDRSNHPSSSSLSHATDKVNTICDALRSILEERGVEQYIETILTTHVCKQPADYESGLQVLLTLQSDHPEIVEDAIKYIIFLSDVNRLYDVALGMYNFQLVLMIAQYSQKDPKEYLPFLRELRALDKWDQRFRIDDHLFRRESALRNLKQSGPERFEEASSYLSRYELYDEAFKLYADEPEHLEVVHDLYGDYLYDRRDFADAAISYILGKKESKALKAFEKAHAWRELFTLAKKLEVSEDDTLQICVRVTDHLASRGRHLEASQVFIEHAQDVDSAVDVLCRGADFSEAYRLTSLHDRSDLVESMIHPGLEEAHEALMETFEEMEGQLDKEMNRLKDLRKIRENDPEQFYIVDTEPAIEGVDVATNATTAVTGFTRYTVAPTTVFSQATKLTGMTGHTAKSSKKARKRATGRKGTVDEYEYLIGSIGRLLIRVDEKSAEATTLLRHLILATSDHVELANSLQKTIKSFRTKLESSIELAWEGREDILKEAIESGGTGLEEGLDKSLALIKPQVSVWKGIGMLAISLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MU05</accession>
    <name>A0AAJ8MU05_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_107615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009300.2">
        <property type="nucleotide sequence ID" value="XM_019157660.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MU05"/>
    <dbReference type="GeneID" id="30174317"/>
    <dbReference type="KEGG" id="kpin:30174317"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC73643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="233" mass="25977" checksum="A7032AB9AA98E6D6" modified="2024-07-24" version="1">MSSSPWLMDAEAMVRDFTEKRTDGSRELQPSDDDLRWFAEWAKKDDERKIIMDILKSRLELSWPANYKALVVLSAMPEAELVGLEEKLGKLAESVPPIEGAKYIKEAAKPLHEKAKAAMAEKEAEEMAKKQAAIQAMWGGLWANDAYHAPALQYGGYMGWPYPYAMPPGVARAPAAEWPGKPPEGWTPVPITALPQIYPFSRTGYYAIQPEPPKDIPKPPDPWSVYVGVGPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MU84</accession>
    <name>A0AAJ8MU84_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_107855</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059714.1">
        <property type="nucleotide sequence ID" value="XM_070203613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MU84"/>
    <dbReference type="GeneID" id="30174555"/>
    <dbReference type="KEGG" id="kpin:30174555"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000386">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF39">
        <property type="entry name" value="TRANSPORTER LIZ1_SEO1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC73883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="57264" checksum="9449C801689D741D" modified="2024-07-24" version="1">MTKGKEKISNGYQDTIVLDGEGVAVPQQYQAPPKASWKGRIWDTFDAPPDEQKLLFKLDAVLLVFGCLGWFVKNLDQENLATAFVSGIKEDLEMLQNQYTTATTMWTVGYCIGQIPSNLILLHVSPRYWIPALEIVWRLCTLLTYRYPALHWILGSYYKPNELAKRASLLGTSAGLGTLFSSILQAAAYTNLDGHHKLAGWRWLFIIDAVITLPVAVLGLIFLPAVPGHSGSKPSFWLSQADLDLAKSRMESVGRAPQKPLTWKRVIRYSKSWHFYLLPLMYMVWNNSIKFTGIMAFWLKDKQNPVQRGVSERNHLVMPITALGIIGGWLGGWLSDGVFRGKRWPPILIANIFCLVTALALVNLPLWKNLDGHFALYYLSGFGTNFAGLYFAWINEICGADAEKRALILAMSNDASFVLQSIIPNFVWKQVDYPKATKGLWYTSALCILLLFIIGVVRYLHNRDRSLAIRAANEHADGSLPEAQAEDYNDEEKRRTPQKRVYTMNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HSF1</accession>
    <name>A0A1B9HSF1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Clustered mitochondria protein homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Protein TIF31 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CLU1</name>
        <name evidence="2" type="synonym">TIF31</name>
        <name evidence="5" type="ORF">I206_07837</name>
        <name evidence="6" type="ORF">I206_100022</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">May associate with the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLU family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700119">
        <property type="protein sequence ID" value="OCF46167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007386.1">
        <property type="nucleotide sequence ID" value="XM_019159522.1"/>
    </dbReference>
    <dbReference type="STRING" id="1296096.A0A1B9HSF1"/>
    <dbReference type="GeneID" id="30176206"/>
    <dbReference type="KEGG" id="kpin:30176206"/>
    <dbReference type="OrthoDB" id="771227at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd15466">
        <property type="entry name" value="CLU-central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2280.10">
        <property type="entry name" value="Hypothetical protein (hspc210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03013">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033646">
        <property type="entry name" value="CLU-central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025697">
        <property type="entry name" value="CLU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027523">
        <property type="entry name" value="CLU_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023231">
        <property type="entry name" value="GSKIP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601:SF6">
        <property type="entry name" value="CLUSTERED MITOCHONDRIA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT EIF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13236">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12807">
        <property type="entry name" value="eIF3_p135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103107">
        <property type="entry name" value="Hypothetical protein c14orf129, hspc210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51823">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Clu" evidence="4">
        <location>
            <begin position="407"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="572"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="750"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1069"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1445"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1354"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="591"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="619"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="750"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="801"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1493"/>
            <end position="1509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF46167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC66122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1509" mass="166198" checksum="5E0EFBA586316BAB" modified="2016-11-02" version="1">MSEQPEQLQPQQPNGEVAPVQDVTPVDGEEKVEEQQEVATLPPVTIRFPTPTCPRTIPKSKDSSETRDRLTIFPQPSETVQDIKLLINDWVGAYWLGPYSLRLPFVKGEDGRGIVFTKKEDLSEIRAGEKLNEWLEVQDAFAHLDEDSQRTLEVVREPYGEFTARQSVLRLLELIAPAGSTANTTSTSLALQPGSTIFESVRDGVLSSNGETQYEEVEVSLPSGRKGKGGKKELVKVKRAISNDKSHAFSDWKGDSWTSTNFGDLPFSQPPLEVTPCLRSIQISPFNPPPPHLRQLGHQLYLQVALLEGETLTIICTTRGWYVSKSNVNQFDPSPRSDNNGSISSPIHSLIDLLHSLSPLFSERISRLSPLSTEPPSLDPISTVTIPQAEPAYPWLANVPKPATSAEILRTQLAFLHTGAYGADSVDAARDWNEEIQGIRELPRTNMQERVFREKMLQKVWAEFDQAAVRAVQTVSRGDIPSINPSEDPKAHMYLQSNIFITQGDSDALNAYGHLGGDAAMRISHGKDAAGVKLLNKLDVDGLYMLGHTIVDWQGKRWICQSILPGIFSNRRKEDEEDEGTAQVVATEETDGQKKEDWVKVGESPKSSTEEEADKSAEIEAEAGLEGESENPMMIYGLDSEKPTSIHWDKSTHKLMSQIGQAQRLAAHKIKDGKGEEFEFYASSEVKGLKGTDGRRYLLDAQRLSPVDIEWLEKDYSTEKGTYPHRLAMLRPELLETFWESELKRWARGVADKAQTKKNEEASKEAGPSTTEKSDEKPEEGIAAEVEALKEEQSPAAEAAAAHRAEEEKPLDASVVGDIKQFELRFNPDAFVDQIPSKEVESDKPFLPSTVNDESDPSIKAVRDASVFLRSIAIPAVVLDVLTGNTSGLMDGASLTKHLHGRGINMRYLGHLAATIKQFSAGPDGAEKKESGHLATLKTLVIQEMIFRASKHILRSLIANLQPETSTFAISHFLNCLLGTSYNSSPSATFNPIGVSDREESPEYTKLTPESLRKSIVEEVQSRFRFSLEESVFEESLKKKQLLRELAVRFGFQLAQRDYLFDKDQDVVNGNEEERDGKKDKKAKKTKTPTVKRAHSFEAEDILTLVPVVKSTAPSVTVAEEILEAGRNTINRGSIDLGLEFMLEGLQLYENIHSVIHPEVASVYNQYSQAIHQLARLKIQQVAAAAQQEGSNTDPDQPLGLDISTALRLQRQAITIAERTLGVYHHETAGYYFNLAMLENLEGNAQQALRYFRHVLKLWDVIHGPDHAEINTVLSNAGVVLQAINETTLALALQKQAYESTLSLFGDAHIQTGQSLHQLTQSHFLSGDMASALTTSEKALTIFNARLGEDHSQTKEVKKNVDLLRAVIDNVEKQKERNEQLKKESQERLKAAKERLSLGSNVAGKRRLGSTLTGVNGTNGVRIVDPATLAAAAAAAGHPIDINGQVPAGGSTATEGGAPVADGSDVGARGTESVEELVRFIQGQQVPSASAAKRGKNALRGKRRTGAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HST9</accession>
    <name>A0A1B9HST9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_07571</name>
        <name evidence="4" type="ORF">I206_102203</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894017">
        <property type="protein sequence ID" value="OCF46338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007557.1">
        <property type="nucleotide sequence ID" value="XM_019159263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HST9"/>
    <dbReference type="GeneID" id="30175940"/>
    <dbReference type="KEGG" id="kpin:30175940"/>
    <dbReference type="OrthoDB" id="2563848at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="157"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF46338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC68280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="208" mass="21909" checksum="AE1C97F725C3CA19" modified="2016-11-02" version="1">MNTSNFASGSTPTSNTVSLPSDSTTYNTASLTTSTHATSRSYPNTHPNFPSHLGLPHFSQRNSSVSSLMDAVMGPNNTQSPQQPSPSHYIPTPTALKPSNNPLTGRNPISGLGHGSMSGPGSNRVGGEGLGDWDILGDVTGRINEGLSGKPQDEEAVKALQEKVDKRKSQLPHLENELAALEAQLAQIQATEERLKRAAGSVLTTGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HT22</accession>
    <name>A0A1B9HT22_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Bud site selection protein 20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_07651</name>
        <name evidence="12" type="ORF">I206_102281</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein family.</text>
    </comment>
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        <property type="protein sequence ID" value="OCF46417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC68356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019159342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HT22"/>
    <dbReference type="STRING" id="1296096.A0A1B9HT22"/>
    <dbReference type="GeneID" id="30176020"/>
    <dbReference type="KEGG" id="kpin:30176020"/>
    <dbReference type="OrthoDB" id="24683at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000299">
        <property type="entry name" value="Zinc finger protein 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051879">
        <property type="entry name" value="C2H2-ZF_Maturation_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCF46417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC68356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="137" mass="16045" checksum="E0890FF70B449424" modified="2016-11-02" version="1">MGRLRRSRTHHARRDVHRLARTRVRVKDLDQIEIDLRPGNRAKLERQEIDEDKPGLGQHYCVECAKYYETDLALRNHTKSKVHKRRLKELKEPAYTLKEAEGAAGLTTDNKQRGVEDVVKKFEGMSNDEQQKKEITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HT80</accession>
    <name>A0A1B9HT80_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_07323</name>
        <name evidence="12" type="ORF">I206_106790</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
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        <property type="protein sequence ID" value="OCF46470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="kpin:30175692"/>
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        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
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    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
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            <end position="322"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="470"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="509"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF46470.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC72826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HT94</accession>
    <name>A0A1B9HT94_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1279 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_07346</name>
        <name evidence="4" type="ORF">I206_106766</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
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    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
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    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="FAM210A/B-like"/>
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        <property type="entry name" value="FAM210A/B-like_dom"/>
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        <property type="entry name" value="PROTEIN FAM210B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377:SF0">
        <property type="entry name" value="PROTEIN FAM210B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="238"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF46493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC72802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1B9HUA7_9TREE</name>
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        <submittedName>
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    <gene>
        <name evidence="11" type="ORF">I206_07244</name>
        <name evidence="12" type="ORF">I206_106440</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894015">
        <property type="protein sequence ID" value="OCF46857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008076.1">
        <property type="nucleotide sequence ID" value="XM_019158938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HUA7"/>
    <dbReference type="STRING" id="1296096.A0A1B9HUA7"/>
    <dbReference type="GeneID" id="30175613"/>
    <dbReference type="KEGG" id="kpin:30175613"/>
    <dbReference type="OrthoDB" id="16284at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004489">
        <property type="term" value="F:methylenetetrahydrofolate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.220:FF:000002">
        <property type="entry name" value="Methylenetetrahydrofolate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004621">
        <property type="entry name" value="Fadh2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053806">
        <property type="entry name" value="MTHFR_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00677">
        <property type="entry name" value="fadh2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754:SF1">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21895">
        <property type="entry name" value="MTHFR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MTHFR SAM-binding regulatory" evidence="10">
        <location>
            <begin position="391"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="365"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCF46857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC72478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="644" mass="71898" checksum="3CE5B7F6E09D8D65" modified="2016-11-02" version="1">MPQLTSLLRDRITPFHTFEFFPPRTEAGLVNLLDRIQRLASAPLPSPLAVSVTWGAGGSTADKSLELAEQVVKLGLEVILHLTCTNMPKEKVDQALERCKSLGVRNILALRGDAPRSEEYSTEPNPQPDYFQHADDLVRYIRNNYNDYFCIGVAGYPTPHPDSESSDKDLEYLKIKCDAGADFIITQLFYDVEGFLDWVRICREKGITQPIIPGIMPIQNFASFRRLVNLTKCPVPEAISSDLIPISSDDSAVKRYGAELATKMVKQVLESKLVPGIHFCTLNLEKSVRTILENLKWTSTSAPSIEKSPLVRHNRLIEDDQPQTNGTIAINGRTTVNGSGLGHQISELSVSPSEASQLAQWGLQHNSLPPVPKKGGIQGGATSNSGQGAEDSWDEYPNGRFTDVRSPAYGEIDGWGSGLKITAAQALKEWGTPTTVQELSAFFTSYLRSSPSTPTTPFCDLPLSPESLTILPHLLELNSEKMQCWTVGSQPCVDAVKSEDPIHGWGPRGGYVFQKAFVEFFVKEEEVEKLKEKVELKSQGKISFYAGNKKGKFKTNTEEDTVNAVTWGVFPGQEIVQSTIIETESFLAWKEEAFDIWTEWSLLYPRNSISRKLLEKISSEWWLVSLIHHDYKDKEALWKFLIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HUE7</accession>
    <name>A0A1B9HUE7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S acidic ribosomal protein P1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_07284</name>
        <name evidence="6" type="ORF">I206_106479</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894015">
        <property type="protein sequence ID" value="OCF46897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008116.1">
        <property type="nucleotide sequence ID" value="XM_019158978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HUE7"/>
    <dbReference type="STRING" id="1296096.A0A1B9HUE7"/>
    <dbReference type="GeneID" id="30175653"/>
    <dbReference type="KEGG" id="kpin:30175653"/>
    <dbReference type="OrthoDB" id="2194681at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05831">
        <property type="entry name" value="Ribosomal_P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696:SF10">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="66"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF46897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC72517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="109" mass="10789" checksum="801986F6C6D0C218" modified="2016-11-02" version="1">MSSELAATYAALILADEGIEITGDKIVSLASAAKVEVEPIWATLLAKALDGKDVKDLLTNVGGGGAPAAAAPGAGAAAGGAAAEEAPAEEKKEEAKEESDDDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HUH4</accession>
    <name>A0A1B9HUH4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein CPL1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_07300</name>
        <name evidence="4" type="ORF">I206_106495</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894015">
        <property type="protein sequence ID" value="OCF46913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008132.1">
        <property type="nucleotide sequence ID" value="XM_019158994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HUH4"/>
    <dbReference type="STRING" id="1296096.A0A1B9HUH4"/>
    <dbReference type="GeneID" id="30175669"/>
    <dbReference type="KEGG" id="kpin:30175669"/>
    <dbReference type="OrthoDB" id="2564135at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048661">
        <property type="entry name" value="CPL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038955">
        <property type="entry name" value="PriA/CPL1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192:SF2">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21671">
        <property type="entry name" value="CPL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628118" description="Protein CPL1-like domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Protein CPL1-like" evidence="2">
        <location>
            <begin position="221"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF46913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC72533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="293" mass="30587" checksum="1A2CBC2B44241700" modified="2016-11-02" version="1">MIVTTLIAAIMLARSIQAATYVGCLPSASIPSASTSESGVSLDECFTFCDSSTYAFYEAGSSQCTCGSSAGSSTNYVTSQDSSGACAADEVSTWLLHTAFSFSGCYTSTGSETTMRTTFPNSPEACFTACASYGGAAFSPMGGMYICQCAIDITGTDPRTCPSGAGEAGFYLYSQAIEPEPTAGNARRALRDRRKRAQMMKHQYCPAGLTACVVGSDQESFECVDVQSDLESCGGCMNGLYGSRTSNSSSTGTECSALPNVAMGGVTCTRGQCEISACKYGYTLVDNQCVRMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HUY5</accession>
    <name>A0A1B9HUY5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">NAD-dependent histone deacetylase SIR2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I206_06855</name>
        <name evidence="14" type="ORF">I206_102052</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KV700117">
        <property type="protein sequence ID" value="OCF47080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC68130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008299.1">
        <property type="nucleotide sequence ID" value="XM_019158553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HUY5"/>
    <dbReference type="STRING" id="1296096.A0A1B9HUY5"/>
    <dbReference type="GeneID" id="30175224"/>
    <dbReference type="KEGG" id="kpin:30175224"/>
    <dbReference type="OrthoDB" id="420264at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046970">
        <property type="term" value="F:histone H4K16 deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF9">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC68130.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HV41</accession>
    <name>A0A1B9HV41_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_06918</name>
        <name evidence="3" type="ORF">I206_101990</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
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            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700117">
        <property type="protein sequence ID" value="OCF47140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC68071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008359.1">
        <property type="nucleotide sequence ID" value="XM_019158613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HV41"/>
    <dbReference type="GeneID" id="30175287"/>
    <dbReference type="KEGG" id="kpin:30175287"/>
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    <dbReference type="Proteomes" id="UP000094020">
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            <end position="24"/>
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            <end position="21"/>
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        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF47140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC68071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="409" mass="45015" checksum="9EF01833B3692044" modified="2016-11-02" version="1">MSRPRRAVATQPSVQEVSDSNVDPEFLALSAKKRNRIDKVFERGIAIYEGRSNKRRKIERTSRGKDKESKQNDNRTYSENQGGLSGDDEGDLEEGGFLNNDSGAEGGFMLDDEEGGGFLQEDDGVGGGFLTDDAEVGGGFLPSDEDESSRQPSRAVSIVSSSSKRLPLRLLPSLLTSLGLPSDEDVLAVFRASASGWEDEEQPASRKKRGQEEEDIGGVELKDFRAVCAALMGDDGPNDDEEEEDDDLEDTFELPSEEESESSSLSGSEYGQEPSASMTRKGKNRTSDVKSKDFAETDSSTPAPSRRRGKKNLDIDSSGKVRLNSRQKELAKDTWEMLKPPSSGSQSSKRGDWVGILGRDEVKKWVRELGEMWNEDEIKEMVTLFSTQHEQRGLSFEDFGGIMLRAGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HVA9</accession>
    <name>A0A1B9HVA9_9TREE</name>
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        <recommendedName>
            <fullName evidence="3">stearoyl-CoA 9-desaturase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">I206_06979</name>
        <name evidence="21" type="ORF">I206_101930</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="21" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.1" evidence="3"/>
    <dbReference type="EMBL" id="KV700117">
        <property type="protein sequence ID" value="OCF47201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC68011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008420.1">
        <property type="nucleotide sequence ID" value="XM_019158674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HVA9"/>
    <dbReference type="STRING" id="1296096.A0A1B9HVA9"/>
    <dbReference type="GeneID" id="30175348"/>
    <dbReference type="KEGG" id="kpin:30175348"/>
    <dbReference type="OrthoDB" id="10260134at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000004">
        <property type="entry name" value="Acyl-CoA desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="16" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="19">
        <location>
            <begin position="358"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="473"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="473"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OCF47201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="WWC68011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="586" mass="65643" checksum="D656C3ADA9BC7EA2" modified="2016-11-02" version="1">MSTAAPQTPPAQLRERRPSPVDKLDPAFEPTTPEKEESTLNKLAGVHNIQPTFEPSDRHIPDNYVSYTISKQKYLPPVTWKTLLSNIQWISFLALTITPAVAVYGIFTTSWNTKTAIWSVIYYFITGLGITAGYHRLWAHRAYNASVPLQFALSLAGAGAVEGSIKWWSRGHRAHHRYTDTKLDPYSAHEGFWHAHVGWMLIKPRGKIGVADVSDLSRNKVVRWQHKNYVPLIFLMGFIVPTAVAGLGWGDWWGGFFFAGAARLVFVHHSTFCVNSLAHWLGEQPFDNKHTPRDHFITALCTVGEGYHNFHHQFPMDFRNAIKWYQYDPTKWFIWTMSQFKLASHLKRFPDNEIKKGQYTMKLQELQEQAAHLEWPKSSNDLPVISWDDFKAESKERALVAVHGFIHDCSSFIEDHPGGAHLIKRAIGTDATTAFFGGVYDHSNAAHNMLAMMRVGILDGGMEVEHLKKRPASVASSVSSSPISSAASSASASSVDIQSLADQDEDDRLHQTQLNSQGPAPKAPFGQPQAMIADRWTLSVPPSEKWRIVQAVPEIRPGLLGRTHSLEKITKADSRGETAELIGEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HVK0</accession>
    <name>A0A1B9HVK0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_07067</name>
        <name evidence="4" type="ORF">I206_101843</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700117">
        <property type="protein sequence ID" value="OCF47289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008508.1">
        <property type="nucleotide sequence ID" value="XM_019158762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HVK0"/>
    <dbReference type="STRING" id="1296096.A0A1B9HVK0"/>
    <dbReference type="GeneID" id="30175436"/>
    <dbReference type="KEGG" id="kpin:30175436"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19079">
        <property type="entry name" value="AKR_EcYajO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000004">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="22"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF47289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC67924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="338" mass="38539" checksum="0B1D1EBF64474905" modified="2016-11-02" version="1">MSETKTQMQYVNLGKSGLKVSRLILGCMQYGSGQDWMIPDHDEGIKQLKYAYDKGINTFDTANVYSGGESEVILGEFLKQHEIPRESVVILTKVSGTDGKLEEKGPAGWTNQKGLSRKRIFASVQSSLKRLQLDYVDLLQVHRWDPETPFEETMEALHDVVKNGWVRYIGMSSCWAWQFQLMQQYAIHNRLTPFISMQNQHSAMYREEEREMMPMLKHFGIGVIPWGPLAAGLLCRPFEEMNSTIRGANKPPDGRGEQPSDKLIIEKIENLSKKYNCTMAEIAINWSCNSKWVTAPIVGVRSTERLDELIKGMNMELEENELKEISDLYQSVAIRGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HVU7</accession>
    <name>A0A1B9HVU7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TECPR1-like DysF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_06288</name>
        <name evidence="9" type="ORF">I206_101742</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A1B9HVU7"/>
    <dbReference type="STRING" id="1296096.A0A1B9HVU7"/>
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</entry>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">CBS 10737</strain>
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    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the LCL2 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
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            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Heitman J."/>
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                <person name="David-Palma M."/>
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                <person name="Mohammad A.W."/>
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            <begin position="133"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF48116.1"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HXX9</accession>
    <name>A0A1B9HXX9_9TREE</name>
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        <recommendedName>
            <fullName evidence="2">Rho termination factor-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_05995</name>
        <name evidence="4" type="ORF">I206_107660</name>
    </gene>
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        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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            <taxon>Agaricomycotina</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
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    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894014">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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            <end position="48"/>
        </location>
    </feature>
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        </source>
    </evidence>
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            <dbReference type="SMART" id="SM00959"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF48127.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC73688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
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</entry>
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    <accession>A0A1B9HY09</accession>
    <name>A0A1B9HY09_9TREE</name>
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    </gene>
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        <dbReference type="NCBI Taxonomy" id="1296096"/>
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            <taxon>Dikarya</taxon>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SWIB/MDM2 domain"/>
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    </dbReference>
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        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13844">
        <property type="entry name" value="SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00151">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWIB" evidence="2">
        <location>
            <begin position="269"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF48165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC73727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="507" mass="57108" checksum="882A05ADB47AF334" modified="2016-11-02" version="1">MSVAQAGPSHTPTLTQTPSYSQQPQGDNKRRAEVDADSVRRLKHPRPPLPPPHVLQALVPDSPAFTELLKLEQKLDWTLLRKKAEINDTLGKPTRVKRTLRIFISNTAHDQPWQKPQSQSSSEQTPSTNAPAETAEDATASIEEKKETDGDVTMNESAQPPVKEETKVETLDEGVDVNTGKGIAGWVMKIEGRLLDVGNTRLDRTKRKFSTFLKSVIVEFDNREAPTFPEGNIVEWHAQNVTPPLDGFEILRRGDQNVNARIIIHLNHSPDRFKVLQPLADLISIKEGTRSEIINGVWKLIKVCGAQDKDDGTIIKAIGGLEKIFPQGTETIAFHQIPEMATRYLTHPDPIVIPYTIQVDKDFNFHPKCFDIPFEVEDPLKSKMSSLVQSFEGKEGKEIVQLEDKVGELAYFARDIKQKRDFLESFAANPQSFIQNWLAVQARDLDQMLGYQIGTPGLNGGNIREEDLRRSDLFSLPWVDEAVTVHESARMEQERRLKASQSQTNHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HY77</accession>
    <name>A0A1B9HY77_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_06056</name>
        <name evidence="9" type="ORF">I206_107722</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="KI894014">
        <property type="protein sequence ID" value="OCF48188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009407.1">
        <property type="nucleotide sequence ID" value="XM_019157767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HY77"/>
    <dbReference type="STRING" id="1296096.A0A1B9HY77"/>
    <dbReference type="GeneID" id="30174425"/>
    <dbReference type="KEGG" id="kpin:30174425"/>
    <dbReference type="OrthoDB" id="2564321at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02663">
        <property type="entry name" value="Peptidase_C19G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF733">
        <property type="entry name" value="RE52890P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="7">
        <location>
            <begin position="87"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="155"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="264"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="621"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="680"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="155"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="623"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="646"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="700"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="765"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="791"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="802"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="812"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="854"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="908"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="942"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="953"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="966"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="991"/>
            <end position="1001"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF48188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC73750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1001" mass="107187" checksum="3CD5FA008985C04C" modified="2016-11-02" version="1">MSRLLRGFGTPKQSNDNKVGGSNSNNVTPNGSRPSPTTRRDSVLGEPLESPDLSQSQNNNNSIITASNNKAIPKTPKELVVEKEMLFGLENFGNTCYCNSVIQALYSCEAFKQFVESYPDSKPPLMALGPTPSQKDYNKSMSPILSTFSNGFNGGSQLSPQISKSNPFESPSLNTIASSPNVNNSSSGEKKSRSWTSLGRRPTNSGHGISSANLPTLGGLKEESTNQSPILDEKYSNWKAIEPDPNQSPPSVFQTIQTLFYHLTHSPPHQPLPKKENKDSNSQAQTASLLPGAPPTPIEPTTDGSNKSPTTPGGGINSNVPQGPPLLASLPPPSAARGGGPWQAGKLGRGVVTPEDLLRTVKRENEMFRGMMQQDAHEFLGWLLNQIAEEIELLDKHLKEVNQTINKGSGKTFIQSLFEGVLTNETRCLSCETTSERDELFLDLSIDIEQHTSVTHCLRQFSASEMLCQKNKFYCDSCCGLQEAEKRMKIKKLPNILALHLKRFKYQETTGRYAKLFYRVPFPTQLRLPNTTDDMENPDRLYELFSVVVHIGNGPHHGHYVTLVRSKGRWIMCDDENVEPIDDDDLFRYFGDYPSGAGYVLFYQAVDMDLASLGLKVPEPKTKTTQPVEAQVTQSRTVQALSQPRTELKEVKEHQLVDFSEEPTSIVPTAAVQPSVPAPALAPIESPKQVKKPPPPPPSRKSSTSISGGTITPTGSDSRKNSIPTPRRESVSTPPVQHIVNGNGFIQPQRETQPIPDRQLGFDASPSTVSPTPTRRISGATPPPPPISRGISKSISNGSVLANQTQAQNQTPTKSTTASSRPSTAGSTTFSGLGVNVPNSSAGSNAESVQGIPNGSSTAMSSSIISTSTSSSSGIPTGNSSNVLAKPIPPSQIQSSSIGTGTGNLQPSSMSSSISSNNFSVLGRKPSTTNGGSIGGRDRTISTSSQISNSSGNGNGKEYSGGGSLGRKLSGMSGKLGRSGSMAFGKLGIGKNKDKGDRIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HYY1</accession>
    <name>A0A1B9HYY1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit ASK1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">I206_05233</name>
        <name evidence="18" type="ORF">I206_107223</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
                <person name="Sun S."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
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                <person name="Fitzgerald M."/>
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                <person name="Alvarado L."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="Zeng Q."/>
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                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
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                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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    </evidence>
    <sequence length="283" mass="32112" checksum="594122ECA2C38B29" modified="2016-11-02" version="1">MNLSSNDSIIITQRPSTSLISFKVQCTNPSSHYYQASTNEKPGQVAAAGNNDPPGTSVTDTKSEPSDIPLILFYPCQTSPIVLKDVSDDNDDQSVYSLDPGEGNYIFRPIYSPNTTTAEQRPGRYWQEALSFHEKLGEIFQQRTDEAVKQEDRAFLETFGERINSGDDIPASIRKYYKARSQHFDEALITRFKKIRTEKNMEDMVGWKFVHDTDSYQNYEPRKSLPPGFRPMTPDEVEAEISRYKGWTLGDITLPVRPSKVKGGLYFPVIKPECSKNTDERDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HZ71</accession>
    <name>A0A1B9HZ71_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_05354</name>
        <name evidence="4" type="ORF">I206_107102</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC73136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009794.1">
        <property type="nucleotide sequence ID" value="XM_019157076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HZ71"/>
    <dbReference type="GeneID" id="30173723"/>
    <dbReference type="KEGG" id="kpin:30173723"/>
    <dbReference type="OrthoDB" id="2563899at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628214" evidence="2">
        <location>
            <begin position="19"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF48575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC73136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="213" mass="21438" checksum="916FEBBF5CD262EE" modified="2016-11-02" version="1">MRFAAILCALPLIGSVFAVPTPIKENSIATRDVDVLAIVTQLEADVKAAGSLTNLSVEAEVTACLQVVIGAFNKCGEALGIDIGLDIEADVDIAAIAKRQDVVQEVAQVLANIVVDVNVLVGSISSEVASISVVAALLSQIDSALCLILKGVESILAGVLVLVAGILVDLQCVLSPLLGNVLGLLDALVGGLLSGLLGTVGGLVGGIVGQNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HZJ0</accession>
    <name>A0A1B9HZJ0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Nicotinate (Nicotinamide) nucleotide adenylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">I206_05465</name>
        <name evidence="18" type="ORF">I206_106992</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>beta-nicotinamide D-ribonucleotide + ATP + H(+) = diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21360"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="EC" id="2.7.7.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>nicotinate beta-D-ribonucleotide + ATP + H(+) = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eukaryotic NMN adenylyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC73027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009904.1">
        <property type="nucleotide sequence ID" value="XM_019157186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HZJ0"/>
    <dbReference type="STRING" id="1296096.A0A1B9HZJ0"/>
    <dbReference type="GeneID" id="30173834"/>
    <dbReference type="KEGG" id="kpin:30173834"/>
    <dbReference type="OrthoDB" id="422187at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09286">
        <property type="entry name" value="NMNAT_Eukarya"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000074">
        <property type="entry name" value="Nicotinamide-nucleotide adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051182">
        <property type="entry name" value="Euk_NMN_adenylyltrnsfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045094">
        <property type="entry name" value="NMNAT_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00482">
        <property type="entry name" value="nicotinate (nicotinamide) nucleotide adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039:SF0">
        <property type="entry name" value="NICOTINAMIDE-NUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="16">
        <location>
            <begin position="344"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="257"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
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                <person name="Imamovic A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
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    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
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                <person name="Heitman J."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Murphy C."/>
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                <person name="Roberts A."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
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                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Saif S."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
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                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
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                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_uS11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007176">
        <property type="entry name" value="PRK09607.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCF48716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC72997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="151" mass="15818" checksum="CB8EDE07B0AC43E5" modified="2016-11-02" version="1">MAPKKVRAPQEQAAVNLGPNAAEGENVFGVAHIFASFNDTFVHVTDLSGKETISRVTGGMKVKADRDESSPYAAMLAAQDVAAKCKEVGITALHVKLRATGGTGTKQPGPGGQAALRALARAGMKIGRIEDVTPIPSDSTRRKGGRRGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HZP8</accession>
    <name>A0A1B9HZP8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutamate--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I206_05516</name>
        <name evidence="16" type="ORF">I206_106941</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Glu) + L-glutamate + ATP = L-glutamyl-tRNA(Glu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC72977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009954.1">
        <property type="nucleotide sequence ID" value="XM_019157236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HZP8"/>
    <dbReference type="STRING" id="1296096.A0A1B9HZP8"/>
    <dbReference type="GeneID" id="30173885"/>
    <dbReference type="KEGG" id="kpin:30173885"/>
    <dbReference type="OrthoDB" id="10250478at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000037">
        <property type="entry name" value="Glutamine--tRNA ligase cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000004">
        <property type="entry name" value="Glutamyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02076">
        <property type="entry name" value="Glu_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004526">
        <property type="entry name" value="Glu-tRNA-synth_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00463">
        <property type="entry name" value="gltX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF5">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST C-terminal" evidence="14">
        <location>
            <begin position="36"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="704"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCF48735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="WWC72977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="757" mass="84925" checksum="586B197835E231D8" modified="2016-11-02" version="1">MPSVVIPLVQTPPFTLIALALIQGIPVSWDTESGETGQASYGEIKGAEEVRQELEKGVAGKEIPLPPLPTLLAANSTFQEVSSVLDALDDYLAYRTYFAGSKFGFGDATIWGTIRGNNSAIGSIKKPGRPHLTRWFNHVETLSVPQNALKTFQQARSEMDKGKKTKRLETVDVVLPNAVKGKVVVRFAPEPSGFLHIGHLKAAILNRFLADQYQGKFILRFDDTNPLKEEGEFEDAIKEDLDMIEIGFDKVVHTSDHFEKIQEITEKLIRRGDAFMDDTDGETVKEQRRAEIPSKNRDASIEDNVARFKEMLKGSEEGKKWSLRAKIDYQHKNGSMRDPVIYRYVEGSHHITGTKFKAYPMYDLACPIIDHLDGVTHALRANEYYARHEQYQWFLEKLGFPKIEIFDFSRVDFVYTVLSKRKLKFLVEKGVVNGWDDPRFPTVRGIRSRGMTVQGLKNYILGQGASQAQLQLEWDGIWTVNKKVIDPAAPRYWAIAEDKAVPVTIAGYTEGEVAVEKPLHKKNPEIGNKKLILSDKLLVEQEDAVSFGDNEEITAMDWGNVFVSNKKTNSNGEVESLEFKLHLEGDFKKTSKKIHWLSAPSTKNALVPVTLIEYDYLITKKKLEENDNLEDIINPKTEYRVKALASAEVVNLKKWEIIQFERKGYYICQGTKDAEGRMEFGFIPDGRLQTITLKATPAAEKPKVAGASKGSWGKPVSTKPTITADSANSDGTKILLSNGTSGFKIPVKSGMFEADKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I0D2</accession>
    <name>A0A1B9I0D2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Allantoin permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_04598</name>
        <name evidence="8" type="ORF">I206_105778</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF48911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC71819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010130.1">
        <property type="nucleotide sequence ID" value="XM_019156328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I0D2"/>
    <dbReference type="GeneID" id="30172967"/>
    <dbReference type="KEGG" id="kpin:30172967"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF0">
        <property type="entry name" value="PURINE-URACIL PERMEASE NCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="490"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCF48911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC71819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="572" mass="63408" checksum="5341407B3FF421CA" modified="2016-11-02" version="1">MAPPSDYTFMEKVKFTFSSPKNFHQAITLDSAKSKFINEDLIPSPPERRTWTAWSYLAYWWSEAWNITTWSLGSSLIALGLSVGNALLVILFANILSALVIIANGFAASRYHIGYPVLARATFGMYGHYFFVLIRAILGIIWGGVQLYFEGQFISLMLRCIFPSWERLTNTIPESQGITLQVLIGFVLAFIVTIPFMLIHTTKIKHLFSVKSFVMPLAGLGVVIWATKANGGVSAGVLSTPVDKSNVAIYAWNIIAQFNSVMGSNSALIVTVPDLARYSKRPRDQVFGQLLGLPMGIVCAAFGVITTAAVQNMWGEAFWNPYDLFNGILDHTYTSKSRAGVFFVSLVFCFATLGTSIACNIVPFAADITCMLPKYVNIVRGQFLCLIIAFAITPWHILTSAPTFLNFLGGYSIFQGSVVSIMLVDYFLVRKGNLDIGALYDGSTKSKYFFTMGINWRSIVAFIIGFIIPLPGFIGSFGTVTVSISASRMFYLGWELSFLSGGLAYWILCLIFKVPGQEDCQRSFGDMIHDEWILPDGETNLESPTTTRNQAQNNGEYEDYEKNVEGVRVNVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I0V9</accession>
    <name>A0A1B9I0V9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_04857</name>
        <name evidence="2" type="ORF">I206_106034</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010388.1">
        <property type="nucleotide sequence ID" value="XM_019156586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I0V9"/>
    <dbReference type="GeneID" id="30173226"/>
    <dbReference type="KEGG" id="kpin:30173226"/>
    <dbReference type="OrthoDB" id="10623651at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCF49169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC72074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="485" mass="56733" checksum="F97A788562CDF445" modified="2016-11-02" version="1">MTSESSITRTSLLDLDDNLLLLIVSFILGDSDIPLPSFRPHISEPIDLGNPGVKTHYLSLKSTCRRLYHLVPYRLLHVPLCSWPDLKWWDEECPENVLRGIRRVMIDIEDFESESESEILSCQTAKLASSTKINIIIYNYVVSFLNKLTNLEELFIGSLPFTVNFDHMEDDDWRKPSCYPLFPALKSIAFEPRLSDYLPKVFKSFIAAASHLRHLKVPGIFTVCNDSIVWHTRPRGLRQDDFAELPYLETLHLRVHQRDRIRVLSNITKGYPKVSSLNITPCKWMGFSAEPSIRLGARQTDAYSDEWIFKEIRERDINLGGTMSISAADMEDWRADDDWTAFLDPLSQFRYLEDFDCIIELVVAYVSDYQRETDWYSFGRYHTNNKWKEKNPRLRTGCKDSKIQLFSAMRAAARIISEKCSSLRRGYFWQWSHEDTEEMSERTVERWCWTKEESGEIKIVPWSEEIPYEMTLKCGRDLLRTWKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I1J0</accession>
    <name>A0A1B9I1J0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ENTH domain-containing protein c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_05090</name>
        <name evidence="4" type="ORF">I206_106264</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </source>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
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                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
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                <person name="Griggs A."/>
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                <person name="Imamovic A."/>
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                <person name="Birren B."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
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                <person name="Imamovic A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
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    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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            <strain evidence="10">CBS 10737</strain>
        </source>
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        <location>
            <begin position="17"/>
            <end position="372"/>
        </location>
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        <source>
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        </source>
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    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="EMBL" id="OCF49433.1"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
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    </evidence>
    <sequence length="380" mass="40906" checksum="BCF442E09FECD88C" modified="2016-11-02" version="1">MSSIEIKSDNPSFVLHGIEDVKYDVREVPEIKNDECLIAVTKTGICGSDVHYLCHGRIGDFVLDKPMCLGHESSGVVVKLGPGVKSDGRITTGSRVAMEPGVSCRTCTECKSGMYELCPHMAFAATPPTIYGTLCRYYVLPADMLHPLPDTVSFEDGAMMEPLSVGVHSVSTLGQLRSDQVVIVFGAGPVGLLCMAVAKALGARRVIAVDIQQERLDFARSYAASDIFLPGAKDPNEAMDVYCARVADEIRATLNIPARDHGAVDLAIEASGAPTCIQMGINILKPAGTYVQVGMGRNMNVPLPLFHVINKQLKVLGSFRYGPGDYPLAISLVERGLIDLKPLVTHRFEFESAKEAFEVTKLGRDESGKGVIKAIIDGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I1M6</accession>
    <name>A0A1B9I1M6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">D-aspartate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_03967</name>
        <name evidence="9" type="ORF">I206_104452</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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    </reference>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
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        <property type="protein sequence ID" value="OCF49446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC70501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019155707.1"/>
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    <dbReference type="STRING" id="1296096.A0A1B9I1M6"/>
    <dbReference type="GeneID" id="30172336"/>
    <dbReference type="KEGG" id="kpin:30172336"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006181">
        <property type="entry name" value="D-amino_acid_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF11">
        <property type="entry name" value="D-ASPARTATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628298" evidence="6">
        <location>
            <begin position="21"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="7"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF49446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC70501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="369" mass="40597" checksum="6131B0DB4D7D9C5D" modified="2016-11-02" version="1">MTSSRPIVIIGAGIIGLTTAVRLVESEGFDSSEHPVHILADHLPNDPLDAYYASTIAGAHHLSFAADEDVNQRKWDSRTFQVMHDEWKNGGEKTGLMLLKQTEFYVGTDNHLKIYEEHPEFTVLDQSTLSNSIDHSISFTSLTMTPAVYLNRLLRRLEGKVQIHRYHLSSLTNLNHSSCTALIGISSPLAVFVCAGIGALTLGGVEDQDVFPTRGQVVKLKAPWIRSGWTRQVGSLDGGEGGERTYIIPRPDGDVIVGGTREQGDWYPYPRPETTTDILRRAREIFPEIIPPYSVHSDTLSPLDEIVEGVLVGFRPSRVGGIRLEVGEDLYLGNEKVTVIHNYGHGGAGWQSCWGTAEDAVDTLLKALS</sequence>
</entry>
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    <name>A0A1B9I1R0_9TREE</name>
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        <recommendedName>
            <fullName evidence="4">transketolase</fullName>
            <ecNumber evidence="4">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
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        <name evidence="16" type="ORF">I206_104434</name>
    </gene>
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        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="11">Binds 1 thiamine pyrophosphate per subunit. During the reaction, the substrate forms a covalent intermediate with the cofactor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010683.1">
        <property type="nucleotide sequence ID" value="XM_019155725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I1R0"/>
    <dbReference type="STRING" id="1296096.A0A1B9I1R0"/>
    <dbReference type="GeneID" id="30172354"/>
    <dbReference type="KEGG" id="kpin:30172354"/>
    <dbReference type="OrthoDB" id="10267175at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07033">
        <property type="entry name" value="TPP_PYR_DXS_TK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000004">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000012">
        <property type="entry name" value="Transketolase, variant 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055152">
        <property type="entry name" value="Transketolase-like_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005478">
        <property type="entry name" value="Transketolase_bac-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049557">
        <property type="entry name" value="Transketolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00232">
        <property type="entry name" value="tktlase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="TRANSKETOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522:SF6">
        <property type="entry name" value="TRANSKETOLASE-LIKE PYRIMIDINE-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22613">
        <property type="entry name" value="Transketolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="14">
        <location>
            <begin position="386"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="448"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="145"/>
            <end position="147"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="500"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="508"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="512"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="561"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="13">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="13">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCF49464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="WWC70483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="724" mass="79806" checksum="82A45BAE3043CEDD" modified="2016-11-02" version="1">MTTVAVGQPVNGHSHLVKDAATTSKITSPGEEQLVLNTIRCLAADLCQQYKGGHPGTVMGAAAIGIALWRYEMKYNPANPEWFNRDRFILSAGHACLFQYLFLHFSGYEAWTLDQVKNYHSPKTYGSMAAGHPEIEYPGIEVTTGPLGQGISNAVGMAIASKNLAAIYNKDDIKPIDNKIWCFTGDGCIQEGVGQESISLAGHLGLDNLILVYDNNSVTVDGRIDNCFTEDTSAKLLAQGWHVIDVYDGSNDLAAVLEGFDKAKRLKGKPIFLNIRTVIGYSSRKANTGPAHGQALGDDEVAYVKTQLGFKPEDRFVIPPKVYEYFSGIKDKGAKVEQQWNETFSQYRRKYPAEHEELSRRISGEWTTEDWQHSLPSKADLPQAAQPTRKSSGIVVQALAPKYKTFVAGSADLLESTFVNFKGQVEFQKPGSGLGDYSGRQIRYGIREFGMVGIGNGIAAYQKGAFIPIMSTFFMFWIYAAPAARMAALQQLRFIGIATHDSIGIGEDGPTHQPVALASFYRALPNINLIRPADAEECMGMWTLALDEQSKNTPSIFTLSRQPVPLLPGSDRNKVQSGAYIVHGADIEEPELTIIATGAEVYRAIDTAEKLKSLKKIRVVSMPSQRHFDLQSIEYRESVLRPSSNLVVAIEAWASYGWAKYAHASLSMHTFGHSAPQQQLYDHFGFEPSNMASKIDAWANKWISKGRLPGLGEFEELLLGYVQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I2L6</accession>
    <name>A0A1B9I2L6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_04232</name>
        <name evidence="12" type="ORF">I206_104193</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010927.1">
        <property type="nucleotide sequence ID" value="XM_019155969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I2L6"/>
    <dbReference type="STRING" id="1296096.A0A1B9I2L6"/>
    <dbReference type="GeneID" id="30172601"/>
    <dbReference type="KEGG" id="kpin:30172601"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000003">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF1">
        <property type="entry name" value="AMMONIUM TRANSPORTER AMTB-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="399"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="10">
        <location>
            <begin position="43"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="489"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="536"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="574"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCF49708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC70243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="597" mass="64384" checksum="4E584D6AB9B159C2" modified="2016-11-02" version="1">MVNLTYGALTTLSDGTLSFEPLGTDILATLQGTTSAFDPGDIAWVLTSAALIVFMLPGLGYLYSGLARRKNALSMLFLSLVSLGIVSFQWFFIGYSLVFSESGGSFFGDGRNVGFRNVLERPVPESNGKLPEIVFATYQLMFACLVPAVLLGAAAERSRILPAMIFIFCWTTLVYDMLAHWIWSSNGWANKWGILDYAGGVPVEIASGMGGLAYSYFIGKRRGYGTERVAFKPSNVGHVVLGTVFLWVGWLGFNGGSCFAASLKAAMAVFVTNLAGSVGGITWLIMDFRLERKWSMVGFCTGAIAGLVAITPAAGFVGAPAGALIGLVSAAVSNLSTRLKVTMRVDDPMDIFAVHALAGVVGVLMTGLFAQSSVAANDGFSEIAGGWMDHNWVQFAKQIVWALVGLSWTFVVTYAIMFVINLIPGCHFRSTEEAEIVGMDEVELGEFVADYAFHHRDLEGLFDPNELSRFNSATQFHLTSMAPRSYLRPGQAHMTHHNGSSNGNGNYPPTMPRGGAAAMDAQYSEQNQGLNEKPRSRSRGRTRSRSRQRASTPSGMDKVEEVNSSDEVELRKLGNTTSSTLEGSSLNTGSSDFSQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I306</accession>
    <name>A0A1B9I306_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methionine aminopeptidase</fullName>
            <ecNumber evidence="6">3.4.11.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_04457</name>
        <name evidence="9" type="ORF">I206_103969</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="6"/>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011145.1">
        <property type="nucleotide sequence ID" value="XM_019156187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I306"/>
    <dbReference type="STRING" id="1296096.A0A1B9I306"/>
    <dbReference type="GeneID" id="30172826"/>
    <dbReference type="KEGG" id="kpin:30172826"/>
    <dbReference type="OrthoDB" id="3209743at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF8">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1D, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="7">
        <location>
            <begin position="87"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF49926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC70025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="321" mass="35887" checksum="089E98813AE443A1" modified="2016-11-02" version="1">MFKPTFRNFNQYKYLAGPSKFGIYPVLPSSFALTSYPYPRDVPSSIPRPEYVPNNFFIADWGEHDEVEIKESKARRIELGGEEEIGLREVAKMVRDLLKDVGKLVKPGITTNDIDRFVNDRITSQGGYPSPLGYSSYPRSCTTSVNNVIAHGIPDDRPLHPEDIINVDLTIFYNGYHGDTSATFVLPEVDKAGRDLIEATKEALEIGIRACKPGMKYKDIGTEIEDFARQHGFSVNGQFSGHGIGNVFHKPPWIFHCRNSEPGEILPGDCFTIEPCLVQGSNARGELWDDGWTMVTETGARSAQFEHQVLITEDGVDVLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I334</accession>
    <name>A0A1B9I334_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protoheme IX farnesyltransferase, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">I206_04478</name>
        <name evidence="20" type="ORF">I206_103949</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="20" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011166.1">
        <property type="nucleotide sequence ID" value="XM_019156208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I334"/>
    <dbReference type="STRING" id="1296096.A0A1B9I334"/>
    <dbReference type="GeneID" id="30172847"/>
    <dbReference type="KEGG" id="kpin:30172847"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18573">
        <property type="entry name" value="ABC_6TM_ABCB10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000604">
        <property type="entry name" value="ABC transporter B family member 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000004">
        <property type="entry name" value="Protoheme IX farnesyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="893"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="936"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="964"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="987"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1045"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1090"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1149"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="18">
        <location>
            <begin position="168"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="490"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="76"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="732"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1182"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="753"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="795"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1189"/>
            <end position="1201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OCF49947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="WWC70005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1201" mass="129782" checksum="31E044C9DC3EFECF" modified="2016-11-02" version="1">MAVREGLGIARSLVLTTQRIRPTLQPFPSPHLPISRLLSTNVGCNRVRAHLPYPTSHSPSQIPCNNASSTISRIRFNSSSAPSSTKSSPNQQTQRQSTSEESKEDETSEKAPSPIPIHPLAPIPPPSATAEITPTASGSGSTKDPKPDAASILKLLSLAKPQWPLLTIGVTCLSISTAVNLSIPWVIGRIIDFFTPGSQATLLLGLPLEQATGALAIVLLIGAAANSGRSITLRLAGQRTVASIRNQTYGKYLALPPSHIETAGVGDALSRLGQDTSIVGQSLSENLGEGLKAILGAGAGIAAMYLISPTLTYVMLCIIPPIAVGTFFYGRFIRKLSLKTQEAMGGMSKLAEERLSAHRTVTASNTQGSERALYASKVDGVYKLQKRETFANGIFQGANEVAGDIGMIGLLIYGGVLVQRGEITVGDMTSLFIYVNWIEWSLNTLAGFFTGLMKGVGASQRIIGLHALPPPIPLGEGTPIAKSRSGSIELRGVDFAYPSRPDAKVLNGLNLRIDKGERIALVGGSGSGKSSIQLLLLRFYDPTSGSVMFDGQNIKSFVPESWRSRIGIVPQDPILFGGTIVQNIAYGHPNANREEVKLAARVAHCDFIENLPQGYDTIINKNSLSGGQRQRIAIARALVGNPSVLLMDEATSALDSESERAVNAALNDLFANSDITVILIAHRLSSIASADRVVLLDGGAVAEDGSYHDLITRRHGKFRKMVEGQLAKIEIGEPTATDPAPPTEHEALPPPESAVVHASSASESRSVERQGTNASSKERAAIKAPSSHSQRRQNHTSALQRPFFTSQPAPYSPLIKTVYGAANAPTPPLPDLPIPHITAPAAPLSAYRPLTPLNIKRLLTVYSQLSKRNLTILMTLTATTGLALSPLPLSIPLLLNLTIGTLLTSAAANTFNQILEIPIDAQTPRTRVRPLCMRKITPFHAFMFGLTCTILGGTILWYGCNPTTAALGIGNLILYAGIYTPMKRFSVFNTWIGAIVGAITPLMGWTATGGTLWPTSEQPLIFNLPFSGNDKLLSSSNNLNLPNPLTPLCLFLILFSWQFPHFNALSHMIRPFYSLSGYPMLSVLSPKLNSLISLRHTIFLTIPFTIILTPLSGCVDWSFTLTSFLPNFLFLKDSLFFYKKTNELNAKKLFFTSLWYLPVILGLMLIHKNLISWFYSFSSKQEEEEDEKEKEKEKIKQKIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I3E9</accession>
    <name>A0A1B9I3E9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">carboxypeptidase C</fullName>
            <ecNumber evidence="2">3.4.16.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_03351</name>
        <name evidence="9" type="ORF">I206_105745</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.5" evidence="2"/>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011254.1">
        <property type="nucleotide sequence ID" value="XM_019155100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I3E9"/>
    <dbReference type="STRING" id="1296096.A0A1B9I3E9"/>
    <dbReference type="GeneID" id="30171720"/>
    <dbReference type="KEGG" id="kpin:30171720"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF113">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628312" description="carboxypeptidase C" evidence="7">
        <location>
            <begin position="23"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF50035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC71786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="491" mass="54007" checksum="92B5721CFA2A51A6" modified="2016-11-02" version="1">MLAGCFDLFAIVIALASIHTAARSTPSPGQSSFHLTGSSRSAHIVTPHLCNDNTTQYSGYLPNSPIFFWFFPSRSDPSIDPIGLWSNGGPGSSALTGMQFSGPCAVVDDGKGGFGMERNEWSFNDRGSILMIDNPIGAGFSYAPFPTVDNIFDSARLVYDFLQTFITVFPEYAKNPWAVNSLSYGGHYAPAYGSYIQHRNLLLQDLPSPWSDIWETTELAHRSPKFINLTSISVGNGWINGRVQYRAMIEFACGHAQDEGVPMLGDKEECAWAMGLVEQGEKLLNRCYDRFSCAAAGLYTAGIAGLPYAQTGLNPYDYRLSAPYNETAIISFYNTPSVQASLGVNASDTTAERGKVWNAHSESIWSAFVYSGDWETKTDGLMGKLLDTGVGVLVYEGMVDWICNYIGLRRIMSNIPNYQRQAAFNQLAMRDWIIEIEDKPTPAGKYKCLKAGKGKGRLCYLEIDGAGHVLSLDKPREGSLMISKWMNELSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I3F4</accession>
    <name>A0A1B9I3F4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Kinesin family member 20/23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_03383</name>
        <name evidence="9" type="ORF">I206_105714</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011286.1">
        <property type="nucleotide sequence ID" value="XM_019155132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I3F4"/>
    <dbReference type="STRING" id="1296096.A0A1B9I3F4"/>
    <dbReference type="GeneID" id="30171752"/>
    <dbReference type="KEGG" id="kpin:30171752"/>
    <dbReference type="OrthoDB" id="123929at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Zeng Q."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
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                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
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                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
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                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Heitman J."/>
                <person name="Chen Y."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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        <location>
            <begin position="136"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF50205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC71615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="480" mass="50112" checksum="92F1B34A09169089" modified="2016-11-02" version="1">MEFLAQPQLNLERPKNLYPCLAHIHIIPSSDPKATRRLSTGSYGSDDGNALTRVISGGTRRKSSFGTSDNTSNPPSVGGRRLSFGGNKDNTPGGALGGFAREDDKDLQGKWYWRVQVGVTETQLILLPLTQPPNPVLTSPPAPLSHAMPSHSTAPSSGIRSEGSQIEEDGGLVGKMKNLFRKSSTAKDTSETINTNVSATNASTGTATVDTTSSGSAGFGQSGQAERVIDQTPRGEMLPSAKANEMGATNLNANAETGYPGIINGNKLNGIVIPLQAIDKSKVVNGGGKKGEGSWVTVPVLSHFSHFAQSALSEHGGVGSNKPEAFPKSGYIKFEFDKDWIGAKGESELLHHHLTHAINVLPENKDRQPHLAQFHLGGHKQHTSTLPQTREYGPNDESAFEEDDEGPTGQPKDRYTGTGAGMGTHGSGMGLGNATETGMNDMAAGVTGDQGIALGHPVHAGQGGSLSGSSVSGKVGGESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I4M3</accession>
    <name>A0A1B9I4M3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I206_03782</name>
        <name evidence="17" type="ORF">I206_105308</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011679.1">
        <property type="nucleotide sequence ID" value="XM_019155525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I4M3"/>
    <dbReference type="STRING" id="1296096.A0A1B9I4M3"/>
    <dbReference type="GeneID" id="30172151"/>
    <dbReference type="KEGG" id="kpin:30172151"/>
    <dbReference type="OrthoDB" id="17725at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="266"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="365"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="15">
        <location>
            <begin position="402"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCF50460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="WWC71353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="762" mass="83845" checksum="75AFE8E83B8B11EB" modified="2016-11-02" version="1">MPLIGDPLLASLLYGASVTFDLKAATQTVAAIASVATATTVNTTQIVQEQKDDQMGMDSTMPRNLYLAFSGLLLLCMIISHPRFLARLFASLPTSSSQPKKKDQVIIYPYSKQSIESLRPKREVSGGDLSQGWFLRKGRNSRIEISSPISTPDTSSKKDPFNSAFAYDEKSLSSATLDSSSYSNPKYYPPPHIIPLLNHLPFSSTFQFVTPFSILPSHLKSHLTLPQLYLIVGYLILIAFALVWKSDLSPASKDKGYGSDWMRSGLVATAQIPLTIALGVRGNIIGLCVGKGYERLKVYHKIVGRVVFLASTIHGAAYMYKWTVAGKFSAYAAKPFAMWGLLAYFALVLIVVTSLPWVRKAWHGVFEVCHFVGIVGLLVGLALHVAVAIPFCVAAMIIYLISIFFSLTKTRIAHAELQALPGAGTTVITIPGLKTGWRAGQHVRIRVPALGLLKAFESHPFTIASAPDGEGLVLMCKRAGDWTNQLYELAQRSSDFEDRAEGGRNQATIIIEGPYGGLGNTLITSFSSVVLIAGGSGITQSLSLAEDLISKSPTGVVRANTIDLIWMVKNEDNVKPFLTNLLKLINQAKQLEIECLESLKKGENLIKFNNSISLRIKIFITRCPASSPLNLLSNYFDEEFKIEEEEEIFIKHKSIDELKKNNYLSKSDSTKNLKQKNFLPLSSISIKPIKPNFDILINSIIDENSIGLRKRKINSSSSSGILITCCGPFNLIENVRNTIKNVNHQKKLDCGGIEFEDEHFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I4N5</accession>
    <name>A0A1B9I4N5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">I206_03809</name>
        <name evidence="18" type="ORF">I206_105282</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
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        <reaction evidence="13">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I4U5</accession>
    <name>A0A1B9I4U5_9TREE</name>
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        <recommendedName>
            <fullName evidence="4 10">T-complex protein 1 subunit delta</fullName>
        </recommendedName>
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    <gene>
        <name evidence="12" type="ORF">I206_03825</name>
        <name evidence="13" type="ORF">I206_105266</name>
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        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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            <taxon>Cryptococcaceae</taxon>
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    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011720.1">
        <property type="nucleotide sequence ID" value="XM_019155566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I4U5"/>
    <dbReference type="STRING" id="1296096.A0A1B9I4U5"/>
    <dbReference type="GeneID" id="30172194"/>
    <dbReference type="KEGG" id="kpin:30172194"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03338">
        <property type="entry name" value="TCP1_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000010">
        <property type="entry name" value="T-complex protein 1 subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012717">
        <property type="entry name" value="Chap_CCT_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02342">
        <property type="entry name" value="chap_CCT_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCF50501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC71312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="532" mass="57078" checksum="C690BD016F5171CC" modified="2016-11-02" version="1">MAAATASAPTTMSDGSFTDKGKPTEVRLSNMNAAKAVADAVRTSLGPKGMDKMIQTSTGEVVITNDGATILKHMAVLHPAARMLVELSQAQDIEAGDGTTSVVVLAGSLLNAAEKLLNQGIHPTTVAQSFQKAATKAVEYLDDMSIPIDLNDRESLLKAARTSLNSKIVSQYSSILAPIAVSAVTRLVSSSSSNVDLRDIRIVKKVGGTIEDTELVEGLALNQIAMSNAGGPTRMEKAKIGLIQFQLSSPKPDMDNQIVVNDYRQMDKILKEERQYLLNLCKRIKKTGCNVLLIQKSILRDAVTDLSLHFLAKLKIMVIKDIERDEIEFISKSTGAKPVADIDAFTEDKLGSAELVEEHSQSGAKVVKVTGVKNPGKTVSVVCTGANELVLEESERSLHDALCVVRCLVKKRALIAGGGAPEINVSRLLTEYANTLKGKEAYCFQSFAEALEVIPTTLAENAGLNPIAIVTELRNKHALGDKNAGINVKKGIISNILEENVVQPLLVSTSALELATETVALILRIDDIQFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I519</accession>
    <name>A0A1B9I519_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mediator of RNA polymerase II transcription subunit 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_02688</name>
        <name evidence="3" type="ORF">I206_102341</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF50634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011853.1">
        <property type="nucleotide sequence ID" value="XM_019154450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I519"/>
    <dbReference type="STRING" id="1296096.A0A1B9I519"/>
    <dbReference type="GeneID" id="30171057"/>
    <dbReference type="KEGG" id="kpin:30171057"/>
    <dbReference type="OrthoDB" id="2564926at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="321"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF50634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC68414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="39808" checksum="6D1F2E218BD37A3D" modified="2016-11-02" version="1">MDLVQNGGSSKSPRAQAQSQSRNQVESDVIMDNADLQRTSNFILPQWDIPPPRHLHSSQDLISLLHLDTLYNTYVRPYAEQNPDDNADVQGGDKKNINGPNRQFRRKKMEKGYWHLIEDCIDPTPTGTKIENQSLLPISQDFMNPTGIPPNLFADQIQMLPTEAFQVATLEVGLKEDGYSGGIKVGVREAEERRKKKRAAKLSIGPISSNTELKNQGSHVIPSPSLPSPSFPYQIPGQSNSTPGTPLLPVLPPQKFPNQNTFSRKTSFPSNINQGQTQGIKPFPIKGQNQYQSGQGKPYNPNKRPGSIDFGNSNSQKRVKSGSVGPVGSGSRSASPMPSNSQGQGSIQGSNKIKIGMRSKTEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I550</accession>
    <name>A0A1B9I550_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL14m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_02708</name>
        <name evidence="8" type="ORF">I206_102361</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF50654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011873.1">
        <property type="nucleotide sequence ID" value="XM_019154470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I550"/>
    <dbReference type="STRING" id="1296096.A0A1B9I550"/>
    <dbReference type="GeneID" id="30171077"/>
    <dbReference type="KEGG" id="kpin:30171077"/>
    <dbReference type="OrthoDB" id="274765at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.150.20:FF:000005">
        <property type="entry name" value="50S ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005745">
        <property type="entry name" value="Ribosomal_uL14_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_uL14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01067">
        <property type="entry name" value="rplN_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCF50654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC68434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="150" mass="15863" checksum="5D53FBDF9D975F3F" modified="2016-11-02" version="1">MIGLKGLLNVIDNTGALKVECINVLKVKTRLKSTGTATVGDEIVCVVNKARPIPANEVIKNPSSSSNIQKIRKGDVRRAVVVRVKKTVQRVDGSVVRFDDNAAVLLNNKGEMLGTRIVGPVAAELRKSKGGAAGAGGRWGKILMLAPKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I579</accession>
    <name>A0A1B9I579_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alcohol dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="9">1.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I206_02732</name>
        <name evidence="14" type="ORF">I206_102385</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a primary alcohol + NADP(+) = an aldehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15937"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:15938"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:15939"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.2" evidence="9"/>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF50677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011896.1">
        <property type="nucleotide sequence ID" value="XM_019154493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I579"/>
    <dbReference type="STRING" id="1296096.A0A1B9I579"/>
    <dbReference type="GeneID" id="30171101"/>
    <dbReference type="KEGG" id="kpin:30171101"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008106">
        <property type="term" value="F:alcohol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000158">
        <property type="entry name" value="Zinc-binding alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
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    </evidence>
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    <sequence length="352" mass="38140" checksum="742C0E57FDFF5919" modified="2016-11-02" version="1">MTITHATGYAIKDPKDYFNFELTKYELEPLEDNRVTVAVECCGVCGSDHHTISGGWGPWETKFVVTGHEVIGKVVEIGSKVTEFKIGQRVGVGAQVGSCGECKSCKGPNEQYCRQPVHGYNTLWYDNHEHQGGYSTHVRAQERFVFPIPDALESTDAASMLCGGLTVFSPLVRNGAGPGKKVGVVGLGGLGHYAVLFGNALGAEVTVFSRSDAKKEDALKMGAKRFIATSKGFEKDLQFEFDLIIVTASSSKLPLDELLSTLDVEKKLVFVGMPEEGLSNITSQTLSGNAAALASSHLGNKQEVEKMLKLAVEKNVKPWVNILPMKEAAKAIKAVEDNTVRYRSVLLQDINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I5A9</accession>
    <name>A0A1B9I5A9_9TREE</name>
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        <submittedName>
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        </submittedName>
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        <name evidence="4" type="ORF">I206_102418</name>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 10737</strain>
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    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Murphy C."/>
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                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">CBS 10737</strain>
        </source>
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    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF50709.1"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="OCF50709.1"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="WWC68489.1"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000094020"/>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Tremellomycetes</taxon>
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    <reference evidence="15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-aspartate + L-glutamine + ATP + H2O = L-asparagine + L-glutamate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12228"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-asparagine biosynthesis; L-asparagine from L-aspartate (L-Gln route): step 1/1.</text>
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    <dbReference type="EC" id="6.3.5.4" evidence="2"/>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF50734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="WWC68512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011953.1">
        <property type="nucleotide sequence ID" value="XM_019154550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I5D5"/>
    <dbReference type="STRING" id="1296096.A0A1B9I5D5"/>
    <dbReference type="GeneID" id="30171159"/>
    <dbReference type="KEGG" id="kpin:30171159"/>
    <dbReference type="OrthoDB" id="409189at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000031">
        <property type="entry name" value="Asparagine synthase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000050">
        <property type="entry name" value="Asparagine synthetase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
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    <dbReference type="InterPro" id="IPR050795">
        <property type="entry name" value="Asn_Synthetase"/>
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    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
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    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
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        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006949">
        <property type="entry name" value="PRK09431.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772">
        <property type="entry name" value="ASPARAGINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772:SF2">
        <property type="entry name" value="ASPARAGINE SYNTHETASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="6 10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 10 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="14">
        <location>
            <begin position="2"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="11">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="375"/>
            <end position="376"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="13">
        <location>
            <position position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR001589"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF50734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="WWC68512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="591" mass="66675" checksum="8F5E28A7F979B358" modified="2016-11-02" version="1">MCGIFCCFNRQGDLASYRPRAIACSKKQRHRGPDWSGCYMTKDTIMVHERLAIVGVDTGAQPLVSEDDQLVLAVNGEIYNHLALRKGLKNQDATFKTHSDCEVIMHLYREHGTGLCAMLDGMFSFVLLDKSVEPPRLIAARDPIGITTLYMGYHSSAPDTIYFSSELKAIHEECDNLIAFPPGHFYDSNTKQLERYFKPTWWDGDKKELDIPHNEVDYKLLRETLEASVRKRLMSEVPYGVLLSGGLDSSLIASIAARETDKLADEHEKYRRERKQAIAEGKWVGEEKPLASWPQLHSFAVGLPGAPDLIAAKKAADFLGTVHHEYTFTLEEGLDAIAEVIYHLETFDVTTVRASTPMYLLSRKIKAMGVKMVLSGEGSDEIFGGYLYFHAAPNAKDFHEELVKRVKNLHTADCLRANKSTMAWGLEARVPFLDKQFLEVAMNVDAKYKMFSKGSQQEIDSDGRPKMEKYIIRKAFDCSPDGKAYLPDSILWRQKEQFSDGVGYSWIDGMKDHAASVVSDEKFNAREERFPDSTPDTKEAYWIREIFEHHFPSKAAASTAVRWIPKQEWGVSSDPSGRAVSIHTAAYDNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I5K4</accession>
    <name>A0A1B9I5K4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoglycerate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_02862</name>
        <name evidence="3" type="ORF">I206_102511</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF50805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012024.1">
        <property type="nucleotide sequence ID" value="XM_019154621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I5K4"/>
    <dbReference type="GeneID" id="30171231"/>
    <dbReference type="KEGG" id="kpin:30171231"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF1">
        <property type="entry name" value="HISTIDINE PHOSPHATASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF50805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC68581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="329" mass="37831" checksum="BEC61BA3973C9A0A" modified="2016-11-02" version="1">MPDHNQYHDEPPVAAMQDGGPLISPDLVEKPHSYRYDVVQGFFLQNGPKPKHMEFEDMLERNFGLIDSTPERWNNLRRDVNKLQDEAPEGTLYKVMFLGRHGQGWHNFGANKYGVDPWEDHWTFLNGDGEITWGPDPELTPLGISQARAIQQCWKEQLPCNPPISKEEIRWYVSPLTRTGQTMLESWGELLTGVPEVWEDWREIYGSHTCDKRSSRSYIAERFPSFQIEEGFAEEDELWKADDRETDAHMQMRAQRAMDRLFGENGAKETFISVTSHSAILRNLLAVLHHQPYPLATGEMIPVVVKATRLAPGELGETSTYPVQRVRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I5X6</accession>
    <name>A0A1B9I5X6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamate-rich WD repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_02985</name>
        <name evidence="11" type="ORF">I206_102632</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="OCF50923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1296096.A0A1B9I5X6"/>
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        <property type="component" value="Chromosome 3"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:ribosome biogenesis"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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        <property type="entry name" value="Beta-prop_EIPR1-like"/>
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        <property type="entry name" value="Glutamate-rich_WD_repeat"/>
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        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
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        <property type="entry name" value="WD40_PAC1"/>
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        <property type="entry name" value="WD40_rpt"/>
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        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="8">
        <location>
            <begin position="89"/>
            <end position="162"/>
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    </feature>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF23609"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC68698.1"/>
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    </evidence>
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        <source>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I6B6</accession>
    <name>A0A1B9I6B6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_03141</name>
        <name evidence="4" type="ORF">I206_102786</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="OCF51075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC68850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_019154891.1"/>
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        <property type="entry name" value="AGP_Transferase"/>
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    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="155"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF51075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC68850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="507" mass="58836" checksum="22E470643C03D161" modified="2016-11-02" version="1">MVPQTPKEKTISRESLKYDYAKCDLDYCDNYALLSHRVCFVCGGNYCYDHVEDIDHHICYTNPPKERIYKGCALDPYVSEVIAIRDNLDYDAVKEEVESIRCGHKCTDIEKPKNYLELRRVTGSFNTHIVIHFDDDVKWVMRIRRKESRCMPEEAIKECHYSELATLKTLEDQGVKIARSFQRPADSKISEDLFYFYQEFVEGVPASKVFPWSFGNKDLTPAGIRFIHDYAAWTIDLEKIISPQNVGCLRFDEEGSTSVGPHIEKGRNLSLNFPYTKGPFVTAKQRWLYSIECRMKWIIDKRACSPRGELHNYLILLEMKDLVTDCEEMEQGPWYLKHYDLHQGNFRVDEETGELRGVIDWEWASFTCKAEAFAPPAWFGAFQFCSTELGKAGHQLIKAYDDLGRPDFAQVVRNSAKYQWLEDTVMGANTQLPFLNATLRSFLYLPDETQGEPKTLEHWTNCRLDRYSADIGLQTLLWRRPTQPLPQLERPPPISKHQKGRVPGEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I6V3</accession>
    <name>A0A1B9I6V3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="16">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">I206_03340</name>
        <name evidence="20" type="ORF">I206_102987</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="20" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Protein phosphatase that specifically binds to and dephosphorylates the molecular chaperone Hsp90. Dephosphorylation positively regulates the Hsp90 chaperone machinery.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:20630"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:47005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="16"/>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF51273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC69051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012492.1">
        <property type="nucleotide sequence ID" value="XM_019155089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I6V3"/>
    <dbReference type="STRING" id="1296096.A0A1B9I6V3"/>
    <dbReference type="GeneID" id="30171709"/>
    <dbReference type="KEGG" id="kpin:30171709"/>
    <dbReference type="OrthoDB" id="445564at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000595">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000039">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013235">
        <property type="entry name" value="PPP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051134">
        <property type="entry name" value="PPP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08321">
        <property type="entry name" value="PPP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033096">
        <property type="entry name" value="PPPtase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 15" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="15">
        <location>
            <begin position="149"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="18">
        <location>
            <begin position="365"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR033096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OCF51273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="WWC69051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="586" mass="64400" checksum="1FB140C2DED701F3" modified="2016-11-02" version="1">MSQNHTELHSSLSEIINGLEPNGGSSSSTASSSSLNDDITPFPSPVLSATSLAGLSLSSDGELEPEVDDDKIVTEEDRAKALELKAEANKAFGAKDFNKSIDLYTEAIALNPKDSTFWNNRAMSKAKMEEHGAAIADATKAIDINPNYSKAYFRRGQSYLAILRPTEAVPDFKKAISTDPNNKAARDQLQLTVKLIRKIEFEKAISVGDTETASSKCLSLLASGACALDTSSSPDFPLPIIPQDPNDRYKPTKEFVQSMIESFKNGGKVPKRVAWEIILGCKRVIEKEKTLVEITIPQGVTCDIIGDTHGQFFDVHNLLNMTTHPSESHYMIFNGDLVDRGSWSVEVALTVFAYKWLYPEYVFINRGNHETNDMNKVYGFEGECKAKLGEMTFKLFADVFTSLPLAVLISASELPVSPKSEGSKPAILSEGKRRFFVCHGGPPVSKDGVTLDEVRKIDRFGRQPGQEGIMCEMLWTDPQEPNGRGPSKRGVGLGFGPDVTRRWCELNQITAVIRSHEVRADGYAIEHDGLCITVFSCPNYCDSTSNKAAYVRMQSNGTLSYHQFDAVPHPDIKPMAYSSGFNFGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I7X4</accession>
    <name>A0A1B9I7X4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_02309</name>
        <name evidence="3" type="ORF">I206_104771</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
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                <person name="Zeng Q."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="Gargeya S."/>
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                <person name="Berlin A.M."/>
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                <person name="Dewar J."/>
                <person name="Goldberg J."/>
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                <person name="Imamovic A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
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                <person name="David-Palma M."/>
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                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
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                <person name="Litvintseva A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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    <dbReference type="RefSeq" id="XP_019013147.1">
        <property type="nucleotide sequence ID" value="XM_019154407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I8M2"/>
    <dbReference type="GeneID" id="30171013"/>
    <dbReference type="KEGG" id="kpin:30171013"/>
    <dbReference type="OrthoDB" id="10343724at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF51928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC71150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="103" mass="11329" checksum="D297F8BC45233EB2" modified="2016-11-02" version="1">MDSSNKHSPTDPFAPRLTPTFSATLAPPTPTSTHTPRSVSITMEDYITDGKDEQDLDLNMIHDFGAAEGVGVDMRDFTNHNDDHDEQDDAKDGILGKFRSLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I8S9</accession>
    <name>A0A1B9I8S9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="5">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Endo-1,3-beta-glucanase btgC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Laminarinase btgC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">I206_02589</name>
        <name evidence="23" type="ORF">I206_105049</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="23" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation. Active on laminarin and lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="5"/>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC71096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013092.1">
        <property type="nucleotide sequence ID" value="XM_019154352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I8S9"/>
    <dbReference type="STRING" id="1296096.A0A1B9I8S9"/>
    <dbReference type="GeneID" id="30170958"/>
    <dbReference type="KEGG" id="kpin:30170958"/>
    <dbReference type="OrthoDB" id="68336at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF17">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BTGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0134">Cell wall</keyword>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00037649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00043078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="OCF51873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="WWC71096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="514" mass="55705" checksum="A8FC02181BF622AA" modified="2016-11-02" version="1">MSQQQRYSAVPGFGPNGTYTDNIMENGVTGNGNLAGNRRNSDFAQVSLLMSTKPKFGQSQSHISSYKDIPSPPHRSHSSFTSNTVGGATAVGAVNMPLMDQSTSRPFASDYARQNIPSEEYFPNTNGNNEKYTGFTNSSTRPNAGRKNKKWLIIGCILFGIAALIGIIVGVVVSQVKKNNDNSSSTDKSNSNNTSVLNDSNDPSDFQKNSNLHQSFWGFAYTPQDALLPWCGATQTNVTRDIQLLSQVTTRLRLYGANCNQSALVLQAIQDTKVNMTVWLGIYVDSNETAYDNQVTAVTDVLKTYGTDHVSGITVGNEYILNTAGTDSTTSSIYLSATKTITDKIQEVNTTIQGLGLSKTLPIGTSDAGSIMSKTLGEGIDYFMANVHPWFGSVSIDDAAEWTNTFFQEFDVTPAALASNNPAVYIAETGWPTQSMNASEANDGAASPGGDASIANLQTFLDTFVCQANNNGTGYFYFEAFDEPWKRQYGGVEPYWGLWDSDRNLKNITIPTCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I9D4</accession>
    <name>A0A1B9I9D4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">(2E,6E)-farnesyl diphosphate synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Dimethylallyltranstransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Farnesyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Farnesyltranstransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Geranylgeranyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Geranyltranstransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_01275</name>
        <name evidence="13" type="ORF">I206_103724</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF51991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013210.1">
        <property type="nucleotide sequence ID" value="XM_019153049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I9D4"/>
    <dbReference type="STRING" id="1296096.A0A1B9I9D4"/>
    <dbReference type="GeneID" id="30169644"/>
    <dbReference type="KEGG" id="kpin:30169644"/>
    <dbReference type="OrthoDB" id="6921389at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF44">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCF51991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC69781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="326" mass="37263" checksum="615F6A3CC74B8433" modified="2016-11-02" version="1">MDYANLRKTLHTPAWTSTQERTLLEPYTYISANPGKEFRGKLIDAFNIWLKVPEESLKVVTRIVRMFHNASLLMDDVEDNSELRRGLPVAHTIYGIPQTINTANYVYFLAMQDLLTLRKTDLSLDNQEKGKEKEVDVVGLVTDELLHLHRGQGLDLFWRDTLTCPTEKEYVDMVLGKAGGLLRLAVKLMMAKSDSDVDYVPLVNLISVWFQIRDDYMNLQSSEYEANKGYCEDLTEGKFSFPVVHGVRADSTNRQILNVLQKKTNSVSLKKHVVDYLRDETKSFEYTKKVIIQLQDQIQEEIKELGGNGPLEKALNSLALKEDDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I9F2</accession>
    <name>A0A1B9I9F2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nickel/cobalt efflux system</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_01461</name>
        <name evidence="11" type="ORF">I206_103535</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NiCoT transporter (TC 2.A.52) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013395.1">
        <property type="nucleotide sequence ID" value="XM_019153234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I9F2"/>
    <dbReference type="STRING" id="1296096.A0A1B9I9F2"/>
    <dbReference type="GeneID" id="30169830"/>
    <dbReference type="KEGG" id="kpin:30169830"/>
    <dbReference type="OrthoDB" id="5197598at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015099">
        <property type="term" value="F:nickel cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004688">
        <property type="entry name" value="Ni/Co_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011541">
        <property type="entry name" value="Ni/Co_transpt_high_affinity"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31611">
        <property type="entry name" value="HIGH-AFFINITY NICKEL TRANSPORT PROTEIN NIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31611:SF0">
        <property type="entry name" value="HIGH-AFFINITY NICKEL TRANSPORT PROTEIN NIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03824">
        <property type="entry name" value="NicO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0533">Nickel</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="480"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF52176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC69592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="499" mass="54957" checksum="35D2E531BFDBDA2D" modified="2016-11-02" version="1">MKIEKFIPKWAKHPDGSPKKLTLLGRATLLILGELLANAICWIAAGICFRDADGLLGLALLAWTIGLRHGLDADHISAIDNATRQLVSLGQLPITCGLFFSLGHSTIVIVVNVAIAISVDIYDKLDKVGSVGGIIGASVSSSFLFLIACINIYFLIITIRQRRAIKKRQELGLPDEENEENKIYGGGCMVRIIRPVLKAVNKSWKMYPVGILFGFGFDTASSIALLAISAIAQRGPSGKEINHGKIVILPFTAGMSLVDSLDSILMLYAYATPSTDSPEGKLTLLQNIPNSKDNLVNIEENVIPDLPSQEVSISRNNSEVIMESEITILEREEEQQELIRIKSPIQEITTINQQQQNDDLNIPSSQIQIIDNLKKERIIRVKTATMSNLSIILTLISIIVALSISFITMMGLIGENCKKCLESAQDPNGGGLQGNWWRFWFKVNDQSGYIGAAIVGCFAFILSSYYGIKFGMSKYKRKTKQHNPLDPTNEQVRDEENVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1B9I9P9_9TREE</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="3" type="ORF">I206_103455</name>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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    </feature>
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        <location>
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            <end position="81"/>
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    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF52256.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC69513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="262" mass="29406" checksum="C5E193574BFB3936" modified="2016-11-02" version="1">MAELIALGGDQDLEDLSWMDDTFQEHIADIRDLFAANNYNQPEAVKLHCDGQPSADRINLFQMLSKSKGQENHQVSRESEAKATISEGEPNQEEDRSHRLGNSLLALQRLSEAIPGVPSSTISNFKQKSQTQLRESETEIKNVIPDTSATGPHDASHCTPSIAVKVLQSTSRENQNSSPTKHCTNPVSLQVEMSIILEFAKLQSNHEFRTLAFNFVAQQMAAARRGLTYQRYLTLKIAEKRAQQNVFLRRSQNEKRSDKADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I9U5</accession>
    <name>A0A1B9I9U5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
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    <gene>
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        <name evidence="9" type="ORF">I206_103350</name>
    </gene>
    <organism evidence="8">
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        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC69411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000094020">
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        <property type="term" value="C:nucleus"/>
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        <property type="entry name" value="Classic Zinc Finger"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
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    <feature type="region of interest" description="Disordered" evidence="6">
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    <feature type="region of interest" description="Disordered" evidence="6">
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        <name evidence="8" type="ORF">I206_01690</name>
        <name evidence="9" type="ORF">I206_103304</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
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    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013620.1">
        <property type="nucleotide sequence ID" value="XM_019153459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IAF2"/>
    <dbReference type="STRING" id="1296096.A0A1B9IAF2"/>
    <dbReference type="GeneID" id="30170059"/>
    <dbReference type="KEGG" id="kpin:30170059"/>
    <dbReference type="OrthoDB" id="273181at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MAP kinase phosphatase, putative"/>
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        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF530">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE DDB_G0271350-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="623"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
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            <begin position="708"/>
            <end position="752"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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        </location>
    </feature>
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    </feature>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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    </feature>
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            <begin position="26"/>
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            <begin position="88"/>
            <end position="107"/>
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    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
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            <begin position="416"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
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    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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    <evidence type="ECO:0000256" key="3">
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
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            <dbReference type="Proteomes" id="UP000094020"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IAH2</accession>
    <name>A0A1B9IAH2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">At2g23090-like zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_01763</name>
        <name evidence="4" type="ORF">I206_103231</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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                <person name="Litvintseva A."/>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="Yurkov A.M."/>
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    </evidence>
    <sequence length="436" mass="48287" checksum="2834317680653E50" modified="2016-11-02" version="1">MSSPIHSYLFSPPPSPPRRAIDKDPNHGLTSIKSLLLPTDFIPRSPNVDGGLKVRSPRTPQQSRFTLDNVYPSGFPSKQKVTDPEATPIASYSTPTTPRRRPSEKTVASPQYVPSNVPSTHIPIPSSLPKPLIRLFFLISLLLSSILLLVFVPSARLPSLRAAGMSRRLALDPNGKAFIDIQGVTSWSDARDKDYRPPQIKAPHMMKRTFEKKTAPAPHPRASRPALTPRPLPSSHELLALQSYLLSSAYNVIPSHVDPTEPIDANAVLGVGVHKLGPLGGDLEQAWLDELKGEREDEVIVWYGGDGRPNHPHEVLDFLASVHGSSRKPTLVPCHSRPDRTTLLSILDRLNLPLRDHPIIMIGNEPIVGDMQSLEELRLSGELENMLSEIGWKKEARSDWKPKYAKVQKKTLTEVEQALQAQALAKFEAELEDEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IBB7</accession>
    <name>A0A1B9IBB7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nipsnap family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_00259</name>
        <name evidence="5" type="ORF">I206_101067</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NipSnap family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF52958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014177.1">
        <property type="nucleotide sequence ID" value="XM_019152039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IBB7"/>
    <dbReference type="STRING" id="1296096.A0A1B9IBB7"/>
    <dbReference type="GeneID" id="30168628"/>
    <dbReference type="KEGG" id="kpin:30168628"/>
    <dbReference type="OrthoDB" id="10262843at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000004">
        <property type="entry name" value="NIPSNAP family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012577">
        <property type="entry name" value="NIPSNAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051557">
        <property type="entry name" value="NipSnap_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017">
        <property type="entry name" value="NIPSNAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017:SF17">
        <property type="entry name" value="PROTEIN NIPSNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07978">
        <property type="entry name" value="NIPSNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIPSNAP" evidence="3">
        <location>
            <begin position="208"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF52958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC67160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="307" mass="34521" checksum="898F0CCCA817CD77" modified="2016-11-02" version="1">MSFLSLRTATRAPRVIAPLAASLHTSPLVNNKKVTPGEPEPETDPKKGGEGFFGSLLYGSKEAKAAGLVDPSGGQHGQHSKLVGRGKYVHEKITHQIVPSKRDEYLAAAEKYFRELIDHNGEFGRVKLTGSWESVVGTVGEFTHILEYEGYKGYDETSRALKGSKEMQSLQSAILPLLQSRQHQIVSEFSFWPSSPPHDSGYPDGGIFEMRTYQLQPGKLLDWEYAWRRGLEARKRFVQPVGAFFSQVGQLHEVHHIWQYPDMETRKHTREQAWSVGSWSDTVQETVKLAQSMKSTIMVPCPWSPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IBK8</accession>
    <name>A0A1B9IBK8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">26S proteasome regulatory subunit N10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_00109</name>
        <name evidence="6" type="ORF">I206_101214</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S5A family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF52813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014032.1">
        <property type="nucleotide sequence ID" value="XM_019151894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IBK8"/>
    <dbReference type="STRING" id="1296096.A0A1B9IBK8"/>
    <dbReference type="GeneID" id="30168478"/>
    <dbReference type="KEGG" id="kpin:30168478"/>
    <dbReference type="OrthoDB" id="1731724at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000005">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="5"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="233"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="237"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="253"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="332"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF52813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC67306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="368" mass="39173" checksum="5EBD220C9BA55BD6" modified="2016-11-02" version="1">MPLESCMLVLDNSEYMRNGDYAPTRFQAQAEAVSTVFTAKTDSNPESAVGLMTMAGKSPSLLVTPTNDLGKLLSSLSKVQISGTSSLSTSISIAQLSLKHRENKNQRQRIVVFIGSPIEESKENLNKLGKKLRKNNVLIDLITFGEEGRENDDKLSGLIEGVGGEESHLVSIPPGPQFLSDVILSSPILFDGEGIIPGASGSGGEGGFSGVEDGIDPNMDPELAMAIRMSLQEAQEAAARSNPPATTASSSTEQPLINTESSNDTSGSATLLPSAITQPLSNANDSDIPMVSGDKPGDENVVDDVLVDQEEEDEDEDEQLRKAMALSRGDDVDMNEGEDDDDDEAAIARAIAMSLEETKEEENKEPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IBW3</accession>
    <name>A0A1B9IBW3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="10">1.3.1.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">I206_00212</name>
        <name evidence="20" type="ORF">I206_101114</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="20" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>5,6-dihydrouridine(16) in tRNA + NAD(+) = uridine(16) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53380"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:53382"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5,6-dihydrouridine(16) in tRNA + NADP(+) = uridine(16) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53376"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:53378"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5,6-dihydrouridine(17) in tRNA + NAD(+) = uridine(17) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53372"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:53374"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>5,6-dihydrouridine(17) in tRNA + NADP(+) = uridine(17) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53368"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:53370"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Dus family. Dus1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.88" evidence="10"/>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF52911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014130.1">
        <property type="nucleotide sequence ID" value="XM_019151992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IBW3"/>
    <dbReference type="STRING" id="1296096.A0A1B9IBW3"/>
    <dbReference type="GeneID" id="30168581"/>
    <dbReference type="KEGG" id="kpin:30168581"/>
    <dbReference type="OrthoDB" id="272303at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF5">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(16_17) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="18">
        <location>
            <begin position="47"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="534"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="534"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="569"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OCF52911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="WWC67207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="580" mass="64946" checksum="BB8493E6F6D57CC6" modified="2016-11-02" version="1">MTIEASKIATEEVLPKYTKNEHNTPKHDKLEGYEFYRSIGSPKYVVAPMVDQSELAWRLLSKSPLPPSMAGPSETIITPTGKKITRHAGGTHVSYTPMIHAKVFMEAKGAETGKRGDGQFNLTYDEEGGEGIVAGIEGGDRPVFAQFCANDPEILLAAAQKLEHRVDAVDINFGCPQGIAKRGHYGSFLQDEWDLVYKLINTLHVNLKVPVTAKFRIFPSLTKTLAYAKMMEEAGAQILTCHGRTREMKGQFTGLADWEMIKKVKEHVNVPVFANGNILYYEDVERCLEQTGCDGVMTAEGNLSNPAIFLPPSHPHFHPPITVLANRYIDIVSSLKSHTAGSAIKAHMFRMLKPILDTNEELRIKIAQCPYSEEMTEFKELIKGIEQRLEPIVKEAGPSFKPPPIDPKTGYRSLPIFCAQPQIRAKPISTEIGGTEEFVNNDENLKPSTQSGTCLFDRSLRHEKINNKNKVEKCINEECGGVAAIRCPTKACIIHCRINKAIESGLTEEEAKIEFEKNGLIGLGCESHEEKEKLRKERLDRKRKNKAEFRAKNKHRKKNENQIIKARSRSLSLSENENEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IC20</accession>
    <name>A0A1B9IC20_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aldose 1-epimerase</fullName>
            <ecNumber evidence="5">5.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_00304</name>
        <name evidence="10" type="ORF">I206_101022</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>alpha-D-glucose = beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:10264"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="5.1.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the aldose epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.3" evidence="5"/>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014222.1">
        <property type="nucleotide sequence ID" value="XM_019152084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IC20"/>
    <dbReference type="STRING" id="1296096.A0A1B9IC20"/>
    <dbReference type="GeneID" id="30168673"/>
    <dbReference type="KEGG" id="kpin:30168673"/>
    <dbReference type="OrthoDB" id="274691at2759"/>
    <dbReference type="UniPathway" id="UPA00242"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09019">
        <property type="entry name" value="galactose_mutarotase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015443">
        <property type="entry name" value="Aldose_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047215">
        <property type="entry name" value="Galactose_mutarotase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008277">
        <property type="entry name" value="PRK11055.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF0">
        <property type="entry name" value="GALACTOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005096">
        <property type="entry name" value="GALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="78"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>beta-D-galactose</name>
            <dbReference type="ChEBI" id="CHEBI:27667"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>beta-D-galactose</name>
            <dbReference type="ChEBI" id="CHEBI:27667"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCF53003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC67115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="347" mass="37803" checksum="5CE263B3FCD03F38" modified="2016-11-02" version="1">MAVRTFGNHDGVDVLAIDIKSPDGSTTATIITFGAAIHDLSVPTSIEPRSVILGFDALSGYVANKQWHHGAVAGRVANRIAHGRFELDSVKYNIEANEPTGHTCHGGNSGLGHRVWTLENHDQNSVTLGYNSPDGDQGFPGNLKSTITYSIPSTGVFKLEYTARTDNKTPVSLTNHSFFNLDGARGSSVHDNLQQKLTIDADQYTAVDQDLIPTGELADVAGTPFDFTKSRPVEFPDSKTGKPFHYDLNYVLRKPSVSSGLHRGAELISSNGDLTMECWTDQPGIQFFDGAPMDLKNPGLGGAVNGYRAGLCLETQLWPDWIHHPNFQQSVLSPGDTYTHTTEYRFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IC22</accession>
    <name>A0A1B9IC22_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_00367</name>
        <name evidence="4" type="ORF">I206_100959</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014285.1">
        <property type="nucleotide sequence ID" value="XM_019152147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IC22"/>
    <dbReference type="STRING" id="1296096.A0A1B9IC22"/>
    <dbReference type="GeneID" id="30168736"/>
    <dbReference type="KEGG" id="kpin:30168736"/>
    <dbReference type="OrthoDB" id="20109at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000171">
        <property type="term" value="F:ribonuclease MRP activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034965">
        <property type="term" value="P:intronic box C/D snoRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013241">
        <property type="entry name" value="RNase_P_Pop3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28272">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28272:SF1">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="233"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="433"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF53066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC67052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="464" mass="51292" checksum="164EE363BECCB4C8" modified="2016-11-02" version="1">MSLATAKNATAGPSKPKSQAVKTVAVDSGKTIRAQSKKDKAKSNVNNAGQEQVDRAGMSKEVVKAVLASPLTVSWPNIPRHLQNATLHALKELIPSNIADYHVSRARCHQREKRSRRRILRKSDNAEKSNIVDSTENLEASEGDKDTEEHSEVGKKRTSGPSPPEPATKRSRLEVDTAREIDRPLKPEILSHMVLGINEVLKTLESQISSLRMRLMIMGDALNGKITSTLIKSNQKSHLLPTAPRSPSSSPEPEEVKKSETNSQNDIKILEYIIVPLLSINPQSLVSPIPQYCATYNALVYQHQHLSKICRTRLKSSEVEDVIGEAMEEVRVVPLGAVEKEITELVGLRRVACLGIRGSHPSVSLIRNLLPKSVLHPPRHSITLPIPTSSLNIHNSNSNNIATTQKSKPLIPGVHYADLHIKGIKTKIPVDNAARKAKRLEEVRKKRVEAKLKKKEANEKAKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IC28</accession>
    <name>A0A1B9IC28_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_00278</name>
        <name evidence="6" type="ORF">I206_101048</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat cdt2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF52977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014196.1">
        <property type="nucleotide sequence ID" value="XM_019152058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IC28"/>
    <dbReference type="STRING" id="1296096.A0A1B9IC28"/>
    <dbReference type="GeneID" id="30168647"/>
    <dbReference type="KEGG" id="kpin:30168647"/>
    <dbReference type="OrthoDB" id="2096344at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051865">
        <property type="entry name" value="WD-repeat_CDT2_adapter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22852:SF0">
        <property type="entry name" value="DENTICLELESS PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22852">
        <property type="entry name" value="LETHAL 2 DENTICLELESS PROTEIN RETINOIC ACID-REGULATED NUCLEAR MATRIX-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="496"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF52977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC67141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="696" mass="75640" checksum="416637B412183CD1" modified="2016-11-02" version="1">MTNSRDLGDGREPLSSIPLNTPQRVNAVAGPSKHTSSTSKITPSSSTKKLAPIFLTKRRTPTTSTTQYVNNENAPPLSGDGSPISRKRTRIDPPAPNSQSTSISLEYTPSSSSSSSTSTCTSHGHAYSVSGLDVEMDGGKNHVRMHSIHDWFLPSTNLNYERIKDGKKPEIDTSVRVEDLPNNGIWKRQRKRLGLKGIGSTIVDKRRLITAQTPYLTTLVHSLSPYEPLVPPSVLLLPSIHPPTGRPREFAPPLSISFNHVAKSHDAYASKELGLRRLIAIAGEEGGVRILDVDEGLGTHREEKGFWWRAHGNAIFDLKWSKDDSKVLTASGDQSTRLHALTTPTPTLLATLTGHTSSVKTTTFFDPSRSHSDLSTSSSVIASGGRDGNILIYDVRSRGRRNADLDQAHIPRGERERYSDGVPGFVAQPPSRGMELNPVMTIRNAHGDGRRNGTGRTATRSVTSLVALQSMPGILASGGSYDGIVKLWDLRFPAPTTRSPEPRPTCTAMGSLPDPTIYSTSPSRRARSVNALCESPTTGDLYALCGDSKIHSLRPSHILNTSNQDGPEAGELDLRESIGIKTFTDPNLLVSSFYIRLSISPDGRYLSSGSCKGGVMTWDTLNRNTDKATRMTLGEGGVQWPVGKEREVGAVDWGKDMLAASSDDLATRIWRSNRDAAKWLKDDPIKASEEWGGCIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9ICX7</accession>
    <name>A0A1B9ICX7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytoplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_00619</name>
        <name evidence="3" type="ORF">I206_100708</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014536.1">
        <property type="nucleotide sequence ID" value="XM_019152398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9ICX7"/>
    <dbReference type="STRING" id="1296096.A0A1B9ICX7"/>
    <dbReference type="GeneID" id="30168988"/>
    <dbReference type="KEGG" id="kpin:30168988"/>
    <dbReference type="OrthoDB" id="17560at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9ICZ9</accession>
    <name>A0A1B9ICZ9_9TREE</name>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <person name="Heitman J."/>
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            <strain evidence="2">CBS 10737</strain>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
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    </reference>
    <reference evidence="2" key="3">
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 10737</strain>
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    </reference>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
        </source>
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            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF53497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC66622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="99" mass="11590" checksum="BAC6777D72826651" modified="2016-11-02" version="1">MLDFKRFNQQYKGVRSNLTGRLERQDDTYRVERDISIDSISSLHSSYYSSASSREVSPIDSERDERNNQAGWEKIRPLAPQKSVKLIQGMHLQHIRIHS</sequence>
</entry>
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        <name evidence="1" type="ORF">I206_01063</name>
        <name evidence="2" type="ORF">I206_100262</name>
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    <organism evidence="1">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC66361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019152837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IDX8"/>
    <dbReference type="STRING" id="1296096.A0A1B9IDX8"/>
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    <dbReference type="KEGG" id="kpin:30169432"/>
    <dbReference type="OrthoDB" id="198652at2759"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="PGP_Pase"/>
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        <property type="entry name" value="PGP_phosphatase"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCF53756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC66361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="47976" checksum="CE1C242CACD01DA7" modified="2016-11-02" version="1">MTPIQLPNILIYLTGIIRPKLLRPNLKVTSIAQINFKSLKNQGYNAIVIDKDNCLTLPNKDEIYPPYQIAWNNLLNTFNPERVLIVSNSAGTKKDPGGIAAESVSLSLKAPILIHGQNKPGCSKDIISYFKGNLGKPITIRKKLIKENEKVIKEEKEDEEMLRLRWEDEIYKKPLLGYNHPSDSKLNERKGNIVTIEKQLKNSTISNKSNEIENNNNNNNNKEEEEELKLIVIGDRLFTDILLSHRLSLYLNKSKNIKTKNSLPSVLSIYTTSLPKYNDVRLLRWIEEKLSKSKIKGNFNFNQFKLKDKNEESINLNFIENKKQNKFIEFFKWFKISKWKEFYNSLPPLNLKNPKSWKPLPILFGLIKNLNYLISLIFKFIIVKSLNFGYNKFQFFFNKKFQNKSKIKFQE</sequence>
</entry>
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    <accession>A0A1B9IE47</accession>
    <name>A0A1B9IE47_9TREE</name>
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            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="5" type="ORF">I206_100241</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014996.1">
        <property type="nucleotide sequence ID" value="XM_019152858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IE47"/>
    <dbReference type="GeneID" id="30169453"/>
    <dbReference type="KEGG" id="kpin:30169453"/>
    <dbReference type="OrthoDB" id="10659908at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
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    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
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        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="231"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF53777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC66340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="466" mass="51594" checksum="1DCD7AAB59E1AD91" modified="2016-11-02" version="1">MTRSPRNKRRTKTKGSKRIPESSPHSCSAISNRSDLDQIVRGDNDIIDLTETDTEELPTIERKENFPARCTRSKSKFVNASSQTSVEIMDQNISRSSTSTISPKQKKKKRKIPVILIPTSLPTSSPSSRLIDSSAINSLTRTTTTDSEKPSLERNRPIISETNKNKLQTIKQNSRSYASLVISGSATSPGRLATQLDSPNIITHNLASTHIDIANNNEQSIKTTIEMEAECVICSEELSVILSKAEDLGKGGLGGGLSLWSCELVGCGALYCIECVMTYPEQAQSKRKSKSHTGNPACPACTREWDRKGIQDQARAYDPIKYGHTSSLFTTPSTSGISDQPRRIEGFNRTTEIVNPPVITIASPSTVDRIPLYIAPYQGSPRQIEGINRTTEMVNHSVITISRPFTSDNIPLYIPPYRGSPSMNMREGIQPTFVPQTPLTPRPTANHTNIHRRDIHDAEFVRVHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IE82</accession>
    <name>A0A1B9IE82_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Septin</fullName>
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    <gene>
        <name evidence="6" type="ORF">I206_01114</name>
        <name evidence="7" type="ORF">I206_100211</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
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        <property type="protein sequence ID" value="OCF53807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC66310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019152888.1"/>
    </dbReference>
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    <dbReference type="STRING" id="1296096.A0A1B9IE82"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cell division control 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
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        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="21"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="343"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCF53807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC66310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="380" mass="43904" checksum="C5B7341235FC0D69" modified="2016-11-02" version="1">MSDGIGIANLPNQRHKITSQHGAHFTIMVVGESGLGKTTLINTLFATEICAPRNYRQRFAKQLDKTTEIEILKADLEERGFNIKLTVVDTPGFGDYVNNRDSWTPIIDFIDDQHESYMRQEQQPHRKEKQDLRIHACLYFVKPTGTTLKPLDVEIMKRLGTRVNLIPVIAKADTMVPEDLLNFKTIIREVVAAQGIKVYAPPIDPEDETVSEHARIMQSVMPFSIIGSTQDVTTPDGRVVKGREYLWGVAEVENEDHCDFKKLRSLLIRSYMLDLITSTEENHYEAYRLAQMETRKFGEPKVRKLDNPKYREEEEMLRKRFTEQVKLEESRFRQWEQHLIAERDRLNKDLEQAHTAIKALEAELDQVAAYHRQGGTVGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IEA4</accession>
    <name>A0A1B9IEA4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Capsular associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_01061</name>
        <name evidence="3" type="ORF">I206_100264</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC66363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="AlphaFoldDB" id="A0A1B9IEA4"/>
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    <dbReference type="KEGG" id="kpin:30169430"/>
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    </dbReference>
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        <property type="entry name" value="SGNH_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34407:SF1">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF53754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC66363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="526" mass="57162" checksum="9C5A721B6F000DE3" modified="2016-11-02" version="1">MLREVKVGLDDSKGRPGTLYGLSNRIWLLLVGVIGLFTFSRFLFPTPDVVSSPYSSSGGLLTPRDYLNASAADPAPFDFCPVFGPGDHIAEKRGQWGLLKSRLHMGSGARIQRVVQKAMAGLPVSISVLGGSVSACHGAGDDPVSPRCYPAKFFDWWNSVFPHPASELTNGAARRTDSAYFAYCSMHHLPDQTDLVILEFDATDPNDAEWLTHFELLVRSILTRPDQPAVIILGHFSPQIQAQNGFAGPELLHTVVAQFYDVPHISAKGLLYQDYLSDPEQARSAYFTDPVLANPAGHELIADLIISYMQSQICAGWAATMGHAFDVPYMGAPDQSVLGLEGSSNIDGGSKEEIEAEGGGLAAKLRAIRVPQAMLSDRPSDILKFREVNPFCVSANDLINPLPPSHFFGSGWFAYHPTKGAAQEEKHYWYAELAGSKFRVPITLSAGEVAIYYLQNPEDRPLGRAACWVDDNYANAVELSGIADVHDTTTTLTIIDSNVAAGNHYVECNLLGTEGQKTAPFKMLGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L040</accession>
    <name>A0AAJ8L040_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thc1 RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_100970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058406.1">
        <property type="nucleotide sequence ID" value="XM_070202305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L040"/>
    <dbReference type="GeneID" id="30168725"/>
    <dbReference type="KEGG" id="kpin:30168725"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053800">
        <property type="entry name" value="Thc1_RRM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22877">
        <property type="entry name" value="RRM_Thc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thc1 RRM" evidence="2">
        <location>
            <begin position="47"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC67063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="312" mass="32482" checksum="B9AE508C4C4D4056" modified="2024-07-24" version="1">MSISLPNGTLLAAPSSSSTVQLSAAVTRILHLANFSSDLKTRDLQNLFKEWESEKGGYRIKWLDDVNALVVFADASVAKRAYLSLLLHRPPQFSGLIKPYDRPDAAQIIQSLAARSLGHRSAGSTMNGSISFPFPTNTDPAAPQVHSRAMSVTNPLNKSGSISINQGQSISNSLNGGGGGGGGIGHVRGLTAPQRIGGGTIGGSIVGGHHRTGSASSSWNNRLSGSFGGGVLNFASNSANKLPTHNETSISASRSTSESDGEPNIVILDPSATQGLKTRSRITNGNGRRESISAEKAMREVEKALASVEAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L058</accession>
    <name>A0AAJ8L058_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_101000</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058415.1">
        <property type="nucleotide sequence ID" value="XM_070202314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L058"/>
    <dbReference type="GeneID" id="30168695"/>
    <dbReference type="KEGG" id="kpin:30168695"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061459">
        <property type="term" value="F:L-arginine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005290">
        <property type="term" value="F:L-histidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015189">
        <property type="term" value="F:L-lysine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015194">
        <property type="term" value="F:L-serine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF678">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="11">
        <location>
            <begin position="31"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="351"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC67093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="479" mass="52023" checksum="05B2EB983B2319C9" modified="2024-07-24" version="1">MTTERDYGAASPPASPSSSSRPRKAIHEGHASITSSVVNLTNTAVGAGALAFPSAFASMGLIPGILSCAGSAGTAIFGLYCLSRCAAVVGTRPGDEGRKASFNELARLTFGKGWATKLFDLAIAIKCFGVSVSYLIICKTLLPQVCFTLSKVFHHPLPDDSILLASHFWLIVWMIVVIPLSFLKTLDALRFTSQIALLTVVYLVLVVVGWFALKGISPTHGEIVLGRFGSNTLSSFPVQVFAYTCSQNLFPIYNELKNKNQKKMNTVIVASMGSAAVVYEVIGIIGYLTFGSKVGSNIIAMYPPTSLIIAVGRFGIVLLVGLSYPLQVLPCRQSLHHLTHGLFKKAKLLKRPTANQEENSESDEEDESESNPLVPKVDDHGHNVQKSEMSKIEFIVITTAILIAGFLIAYNVHELEIVLGFVGSTGSTIITFILPGFFYFRLFREEAGMTKWWALALGVYGFFVMAFCLTFNILNLVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L067</accession>
    <name>A0AAJ8L067_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_101032</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058420.1">
        <property type="nucleotide sequence ID" value="XM_070202319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L067"/>
    <dbReference type="GeneID" id="30168663"/>
    <dbReference type="KEGG" id="kpin:30168663"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042592616" description="GH16 domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="4">
        <location>
            <begin position="15"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="413"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC67125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="455" mass="50412" checksum="BC5EE33DC5291DBA" modified="2024-07-24" version="1">MYKELLLFLLFTTKIQAKNVTLPYNPERKLLSLEQHGQNSDLGTQILGSRNYESKLDRRMYSQEDITSWTKSEKDKRQLKWDKQIEYSGKTFFEGWEFFAQPDPTYGLVTYVDHATAFARGLAFWTGDGKPGIQVDHFSNVPVGSPRDSVRITTKAMFAGGLFIIDMALMPWGCGVWPAFWTLGYKVEWPTAGEIDIVEGIQAMTNNHTLPGCEINQTSGMYTGQLGNTYCDSTTGGSGCTIGSDSATSFGMPFNEAGGGVFAMLWNGNGVRMWDWNRAQIPADITAETPEPGNWGTPRAAWDASMCDPWKFFQAQVLILNIDLCGVWAGDLYNTFPYCPGTCAEYISDPKNLNNTVMLLNYIKVFQQSGMQSVPEQAHDNSNLTGAGGDAPLNASEVNASVRQTNSAQIPGSSDTANSSSSASDLKIPLMSLSMLWIFMLMWNMILNYGDLYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L1Z6</accession>
    <name>A0AAJ8L1Z6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="9">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_101842</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="9"/>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008509.2">
        <property type="nucleotide sequence ID" value="XM_019158763.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L1Z6"/>
    <dbReference type="GeneID" id="30175437"/>
    <dbReference type="KEGG" id="kpin:30175437"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000050">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF35">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="10">
        <location>
            <begin position="45"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC67923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="502" mass="55000" checksum="891050314772EA56" modified="2024-07-24" version="1">MPSLSSTRSIFSTLRSARPVISRNIRMSSSVPIPKDFNSCLYQPLAEADPEVHKLIEQETWRQFSGLELIASENLTSLAVMEANGSMFTNKYSEGLPGARYYGGNEYTDILENITRERALKAFNLDPKVWGVNVQPYSGSTANFAAFTALINPQDRIMGLGLPDGGHLTHGYYTAKKKITASSVYFQSFPYRVDPKTGIIDYPQLETNANLFKPRLLVCGGSAYPRDWDYQRLRKIADGQGAYLLSDMAHISGLVAAAEQNSPFEYCDVVTTTTHKTLRGPRAGLIFFRKDKEADLEARVNAAVFPACQGGPHNNTIAGIAVALKQAAEPEFKQYAKQVRANAAAMAAVLFKHGYRLQTDGTENHLILWDLRPIGLTGSKVEKICDAAHITLNKNAVAGDTSALVPGGVRIGTSALTSRSMTEKDVEQVAEFLHRVVQIALKTQEEAGSKLLKDFVKAYEGQGEASKLISELKKDVMKFATSFPLPGVPDTSKILRPEGVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L2H3</accession>
    <name>A0AAJ8L2H3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_102767</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058722.1">
        <property type="nucleotide sequence ID" value="XM_070202621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L2H3"/>
    <dbReference type="GeneID" id="30171491"/>
    <dbReference type="KEGG" id="kpin:30171491"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045877">
        <property type="entry name" value="ZFP36-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="CCCH ZINC FINGER/TIS11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547:SF18">
        <property type="entry name" value="PROTEIN TIS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="471"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="823"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="884"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="920"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="471"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="823"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="884"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="920"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="96"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="505"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="596"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="851"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="969"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="165"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="505"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="596"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="851"/>
            <end position="868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC68832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1025" mass="110510" checksum="DBD2F2A5A4304458" modified="2024-07-24" version="1">MINTDMSSPITTPSTPSPKSPNFKLTLPTPPSFSAHRGSRSIDSSTNTSSANLMDLASQDNGCVQDNIAINHGKRLSISSINDPIVYNDGKSNRRVSFSTEHHTISRPTLTQNQNQSNTSSSGGDLKSPIYKIPQRQNSSNNDEEELLDLPDISTTPAGNGTKRPPTSFQNSSPSTTSPSRFSIMAAAKGISIDQSLSSSRTGSFSRSIWSAGMIPSSTSGWISPKPKTPISISSTLKSPISNKLISPPVSAGVEGTASEIAKARGLSIAIIKENGKGVVVPVTPGLSTSGMTGLKSPVSMKSPEIKIIKNNNLYLDDGLASAKSTVVPDTACNLGKKEIILCKFYHTPGLTCTSRPCRFVHNLSSIQQPISGLSSAMPNTSNLSEFRMLSPTAPDPTSGTFANAQITPSTAESEPPSKSITVKKDGQIDLGDVMPGEKVLVADEDGEEVMGQVFFMSGGGKGAMGKSREKWKTVSCKDFAEGHCPYGDYCSFIHEAKLPDESLGRKDNAEIDNKKEETKTREPRLTHRKSASLSSSLAAWTRALPKAILVSSVKIDPQVLHKNETGLSAFAPPFLKDPIAVGETGDLISAQNESTAIRNQSRHITTTPPARASEPLAIPMQPTITAPPRNTAWSKGPPPNLREMTNVKPEHTLESPSTGLGTGIGQHLLPPVSAYSLFGTESDPASPFDPVSHRRKLQELEESLRALPRSNLSNQFRFAQYDSEIPTQTFLSSPINDDKSSGTANHKSGAILNSTTYPWGMPMAPLPGHNDPSVPVIPGGLGVIWTPAGWAVQDAAMKNALRTAEVKARYGGEVKRRTAKNYFRTKPCRFFAEGFCPHGDECTYMHILSPSSPEQTSSSSSDSESLSIGQAFSPPHPKHQTLPCKFYNSSLGCNNGNNCSFLHTRVVPESVMMVERPRPWRTKPCRHFQLGRCTLGDACHFAHVLDPVWMNSGNNPIVDGYGQKTLTEEMLEKTMEEMRQNVNISNDNGEEEEEDDDDVEIVTSVARDLTFSSTSYSPPSSVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L2W8</accession>
    <name>A0AAJ8L2W8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I206_102093</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DHHC palmitoyltransferase family. PFA5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="11"/>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC68170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058604.1">
        <property type="nucleotide sequence ID" value="XM_070202503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L2W8"/>
    <dbReference type="GeneID" id="30175183"/>
    <dbReference type="KEGG" id="kpin:30175183"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF23">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="13">
        <location>
            <begin position="226"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WWC68170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="414" mass="46713" checksum="E75BE2B9DC048789" modified="2024-07-24" version="1">MQDNCPHRVDEINGDHAPVDSFDGPSASNDRAYVKQSEPSAGKERQAKQQRRKRSTPSKPDFWVSRKWAILIVAALACWSFYVVVGKMCTPMIRQQSTSGLGLSVGVGALVGFVIVWLLMIWTYLKMVITGPGMAPQHVPKSTPPGPSDYRLDNLSPPPIPSVPTTFAAEERDPSEFAPIGNLIHETLTTHRVSSDSGTEAPLKGSKVKDWRTIDRPLPPLPPPVRWCQYCEITKPPRTHHCRHCGVCILQFDHHCLWIGQCVGFANHKVGPAIVVAIIILSALFGLFTFAMCLSHVHLIVTGRTTVESFASRDQHEAESRILQQEYGYFFHNNERRKVQKKWKEEWGNTPVDARWVFGTKLEMWEQEMGKSRLGWILPIGKPLGDGIHYENNPRFGPNGEWLKKKDWPKDLQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L3J6</accession>
    <name>A0AAJ8L3J6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_102208</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058627.1">
        <property type="nucleotide sequence ID" value="XM_070202526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L3J6"/>
    <dbReference type="GeneID" id="30175945"/>
    <dbReference type="KEGG" id="kpin:30175945"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000013">
        <property type="entry name" value="Related to multidrug resistance proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF78">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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</entry>
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                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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        <property type="term" value="F:ribonuclease III activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="2">
        <location>
            <begin position="31"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC70889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="436" mass="48954" checksum="B95CBC8099F88121" modified="2024-07-24" version="1">MTRSTQKYDHCLQVVFLPPLPKLDLPPLPKITDSKLEEIVFTHPSVHSMPRSYSTSLFLTEGQAGLDYEKLEHVGDALLEAVAVTLAHELFPNFRQGSAAIMRDKLVSNSTLAQIARQYGMHDRIRCAQDARHALKKNEKVAASVFEAYIAGVYYSYLQSTEESAPRSPTDSTNTFESSSRTSVDFIGGDKMNNPCDEGEAISSDEEYCDAEIYSPTNTDSDDRADFDEDDDFATSLNLLFGDSSSDDEVEKPENVLDRKARSSVSCETSNQADRGISNSFLPTDPSFRTTRTHPRRTRAQAYDYLYEWLEKVLTSIAHFALAHLKVEDMRIKKEHGKSDEEPFIIPLHWKEEDIKAQGGKAILNTHFFELESPVYTESSSNEGRPPTQLWTIHCRVKDKEGTVWTAEGTRTTKQAASNLAAWKICVAMGLIKETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L6P9</accession>
    <name>A0AAJ8L6P9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_104059</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019156099.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L6P9"/>
    <dbReference type="GeneID" id="30172734"/>
    <dbReference type="KEGG" id="kpin:30172734"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF43">
        <property type="entry name" value="STEROID 5-ALPHA-REDUCTASE DET2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="7">
        <location>
            <begin position="109"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="7">
        <location>
            <begin position="260"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC70112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="302" mass="34069" checksum="A44F178AB15FEF5B" modified="2024-07-24" version="1">MIPPASFFPTLLTFHLFPFHAPITLYVLDAPFGRFSSKTSNLNVNGNIAWAAAELVSPMTFATTLLVNAHAPLNYPARILAGLYFAHYAHRAIISPLILSPRRSSLHIVVALAMGLFNLFNGYLVAAGLAFYPPQAEVSWKFWLGVGGWALGFFANVYHDEMLNDLRRQPGERLINHHLPEDDDPKAGRYKIPRGGLFKFVSFPNYLSEWIEWSFYALAATSNPLIPLPPISQLRLQAGLRGSLVKVIAKTWWPSYLLHPAWMFVLAEIASMLPRALRGHRWYKEKFSNYPKERKAVIPGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L6Z2</accession>
    <name>A0AAJ8L6Z2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_104417</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059049.1">
        <property type="nucleotide sequence ID" value="XM_070202948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L6Z2"/>
    <dbReference type="GeneID" id="30172371"/>
    <dbReference type="KEGG" id="kpin:30172371"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16514">
        <property type="entry name" value="RING-HC_LONFs_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327:SF42">
        <property type="entry name" value="LON PEPTIDASE N-TERMINAL DOMAIN AND RING FINGER PROTEIN C14F5.10C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327">
        <property type="entry name" value="RING FINGER PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="590"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="Lon N-terminal" evidence="7">
        <location>
            <begin position="673"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="491"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="537"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="794"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="60"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="192"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="537"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="553"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="799"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="827"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC70466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="968" mass="103949" checksum="6FF1E95D3496D74D" modified="2024-07-24" version="1">MPAPPTSSSSSRTNNMSRSTPPPPYRPLSPSTAQQAALSPGLMSTSSSLAGDRMSGNGNGSLSPSSVPSGSSIASSSTTPNFSSSSSFTTPNLSTAPTSPAQSNLAARSWRPTANVPSHIHRRHRRVGSDEAQANRWLSEDEGVGSSSSGVRRRRSIGSRTRRGDDRDDHDHGDRGGDVGPSSLSGRRPSAKITNTEEAIDAINQSKRSSSSSARPIPQRLTSFDSHSSRINPSSSATVTSQPAVGTDPPRIDQLASEAGHIPLVSSGPLPDFASGNPGDGIATSVPPTSGDLDQDHGSAPTPLEKRQNMVEKLIRILGCALCPPVDGKAPSLHHPITLPCGHTLSAKHIFIPAPPSLQFTNEAAHEIHAAQQRQHQQRLSIWTNLMCPIPTCKRFSPTASASSVLAKVEVPGVESMSEGDENRSSPQRAGLLASGVHYYPPAPPPVPMPVPPPAYSSEDPSAASASPLLDVCVDRILTLVHIERKRLEGHMLGRGGQEETDVDSSSSGSEPEEERSVSPPLHASQASLSQDFALLRSSSTPSGTSTLMSRTGSKRRRGDHKSSRRLPKTSLQQGNSDEFEKELLSTLECDVCAMLLHEPVTTPCQHSFCAKCLSRSLDHSSRCPVCRQDLPSFAFFQDHAVNKVLLTIIKTAFPEEYIERQQAIERDERDSRLDTPIFVCTLAFPGMPTILHVFEPRYRLMIRRCIESTSPRFGMVLPARGTGAPELQGLMEYGTMLEIQSVQMLPDGRSMVETVGTHRFKLLEKGNLDGYTVGRIERIDDVSPEEEIAMEREAVSRATMSRQTVGPSTSASATNVSGPGLLPTGPLTSATPASAPQVQSSLPIFGAPPGLGLGLGGGQVDFAALASQAITAPASGVDDTPETTEELMAVCQAFIEQLRSGSAPWLLQRLNNTYGSMPTDPSEFSYWMALVMPIDEYEKARLLPIRSPRLRLKLIVHWVESLRSSWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LA58</accession>
    <name>A0AAJ8LA58_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I206_106175</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010528.2">
        <property type="nucleotide sequence ID" value="XM_019156726.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LA58"/>
    <dbReference type="GeneID" id="30173369"/>
    <dbReference type="KEGG" id="kpin:30173369"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17963">
        <property type="entry name" value="DEADc_DDX19_DDX25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000849">
        <property type="entry name" value="ATP-dependent RNA helicase DBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="13">
        <location>
            <begin position="232"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="265"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="445"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="8">
        <location>
            <begin position="232"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="153"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WWC72213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="631" mass="68618" checksum="6D1C30C1C668C426" modified="2024-07-24" version="1">MSESTDIPTTNSWADLDDEEDGKVEFKGLNPSASSFNPSSSSSITNTQQQITSLSVMSKADQTPSSLFKEDDAPVASLLSRISGLTTNPDPAESSSTPSTPSDPASSSTSASRPKPNTSNPLFGRALAGVKTDRPPPAQAPAQASTSASGSHQGKELIDNKQEKKEESKMSGFDNGWDEPVQNGNSNSFEDNNEKKTDTSMSEGGLISNEFQVEVKLADLQADPNSALYSAKTFEELNLHESLMKGIYSVGFKKPSKIQEVALPLLLSNPPKNLIGQSQSGTGKTAAFTLNMLSRVDPALLTPQAICLAPSRELARQIQEVVDKIGQFTDIQTHLAVPGSWSRGQKITKHILIGTPGTLVDMLSRKGTIFDPRQIRVFVLDEADEMIALQGLGDQTVRIKKMLPPGVQNVLFSATFPEEVQRFAESFAPEANKLFLKKEDVTVKAIQQLYLECDGEASKFDALSALYDCMTIGQSIVFCRTKATADNIAQRLTEEGHSVASLHGDKDSTSRDDILDGFRNGKTKVLITTNVVARGIDIQQVNMVVNYDVPDLGRDGGFRPDIETYIHRIGRTGRFGRKGCSVIFVHDDRSRDDVNYIMSELGKPMKQINAKNQDDLDELEKALKIALKGPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LA69</accession>
    <name>A0AAJ8LA69_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vacuolar proton pump subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_106106</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059345.1">
        <property type="nucleotide sequence ID" value="XM_070203244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LA69"/>
    <dbReference type="GeneID" id="30173298"/>
    <dbReference type="KEGG" id="kpin:30173298"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:ATP metabolic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:vacuolar acidification"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18112">
        <property type="entry name" value="ATP-synt_V_A-type_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18118">
        <property type="entry name" value="ATP-synt_V_A-type_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01135">
        <property type="entry name" value="V_A-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="ATP-synt_VA_C"/>
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        <property type="entry name" value="ATPase_a/bsu_AS"/>
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        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
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        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
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            <end position="84"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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            <dbReference type="EMBL" id="WWC72146.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="409" mass="45148" checksum="8304A4E078283702" modified="2024-07-24" version="1">MVNADPRVTDSQLAQINAGIWGRSANGLQDCFSSQWFPSYNEIVQLTLPDGTIRGGQVLEVSGKKAIVQVFEGTSGVDTSATRIAFSGSSMKLAVSEDMLGRVFNGSGNPIDKGPKVWAEDYLDINAGLVKRPGATKSVHDGHEDNFSIVFAAMGVNMETARFFKQDFEESGSISNSTLFVNLASDPTYADALREVSAAREEVPGRRGYPGYLYTDLSTLYERAGRVEGRNGSITQVPILTMPNDDITHPIPDLTGYITEGQIFVDRQLHNRQIYPPINVLPSLSRLMKSAIGEKLTRKDHGDVSNQLYAKYAVGKDAASMKAVVGEEALSADDKLALEFLDRFEKEFVGQGSYEARTIFKSLDIAWDLLRIFPKESLNRINPKILAEFYSRKTARQPEEKKEENLIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LBX8</accession>
    <name>A0AAJ8LBX8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_106806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC72842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_070203405.1"/>
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    <dbReference type="KEGG" id="kpin:30174015"/>
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        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC72842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="471" mass="54700" checksum="C9BADC154EA3758C" modified="2024-07-24" version="1">MPTTPYIPWNLWRKIRDIALVILAAIIALDVVGWDVREKVGLSAHSNPYLQPGYLAYSQWNPHDNRWRPFTGSSPPALLASLLRTSWSIRPPSFPSDILDPKGWWEKDVGPDGKEWEDVSWARGTTVLLIGDSVGRYQVKYFCEMAGEPLREMNWTHPFSPHQIVGEEAKAEEDRVPESLEEIEKYQQGSSRDVPRQPPTQKTSETGSSQEDMKAFDVHSTLGKRDEDARHEGDASGYHSHYCHIPGIDLMIVQIFNYGLDEKNFWAFREDYIPPYTIESRISLLALPYIRAMGRASTAPELTYVGSALWDTTRWMREDAADGKDIGDALAQERLNWYRTRTRQAIMHTRHVFPETKIKWSSHHYPLRAMFGWFFEEGNEKQRPNRPQQKLNRLSPLHEASMSAIEDLDDATSEERSVLKQVDMNMWGRRMMGMEDHQKDDLHQKLLPGGYLWADMMLWDLREAVTKRWWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LD64</accession>
    <name>A0AAJ8LD64_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_107850</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009532.2">
        <property type="nucleotide sequence ID" value="XM_019157892.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LD64"/>
    <dbReference type="GeneID" id="30174550"/>
    <dbReference type="KEGG" id="kpin:30174550"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000188">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF9">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="62"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC73878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="507" mass="56780" checksum="166007A587BFABFB" modified="2024-07-24" version="1">MQASNTEDYQEKDEEGRVRAHEVPLDYAGEGGDYNFTADEVERYQLDPKMNNQVLRAYDWRILPISMLMYLFSALDRGNVSNAKSDHMDKDLGFTGNQWNIMLTVFFIPYCLMAYPGTYMSKKFGPERMLPIYMGGWGAMAMINAGVKNFAECLVVRLLLGIFEGCFAASLIMYLACFYTRGELGKRMACWYSTVAVSGAFSGLLSYGLFQVKTTKLHGWQLLFVVEGALTLIAAVASWFILPKYPTQASFLTPEQKVAGVMRLLKDSTTHVNQIMTLKAYIEPAKRWQTWIWGFYAIIYGVANSTASVFLTQIIGRWKYSTVKTNLLTVPPYSVAVVVMWIFVISSDRQRERTMHVFGANALVMVGCIVLAVIPITKISAGYFCTFLIASGSFIPTVLFQSFVQNNTTTENHRAFRAAVCTFGANAGGIVSANIFLSQFAPEYVTPLIVSAAIAALGMVVLACLRIYMVLDNRRRNREQGVNWTSKDVPTAALRNGPDSPSWRHFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MM87</accession>
    <name>A0AAJ8MM87_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ARID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_100721</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058363.1">
        <property type="nucleotide sequence ID" value="XM_070202262.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30168975"/>
    <dbReference type="KEGG" id="kpin:30168975"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ARID" evidence="2">
        <location>
            <begin position="828"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="697"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="765"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="940"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1201"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1241"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1452"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="356"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="412"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="514"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="560"/>
        </location>
    </feature>
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        <location>
            <begin position="561"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="700"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="733"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="767"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="940"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1261"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1302"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1452"/>
            <end position="1469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC66814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1604" mass="176910" checksum="47C648D46F656C10" modified="2024-07-24" version="1">MSNPYQQNGYNPAQLNPALFASLTNQQQLQHQQQQQQQQQQQQMSNPNSIQIQQPQQGNMTMNAAQLQKNPNTNTLDGALQNIMLPMFNRLQGQNVARIEQQRLGLNPQQQQQQQIQQVQQQQNQQFQGLAQQMNMAGLPGMNMMNPNSQQSQSQPPQQQQTYSQQSIQQQQQQQPPTQQQPQQQQLQPQPGQPGYGSLHSQQQGLTMQQLGQQQQNQNQAPQQQQQQQQQQQQQMQNMQGVNVGLVGDSEQGRRLMLQNMLSQATSATQPIQQQQQVPMAQQQQQQQQQPQPQQQPAQSQQAMQPQQIAKLGPPPQSISELLKQRPEILQLLLSKHNGDYQAAMTDMQRSWAQMQANPQQRVNQAQAQMQGQAQNQQIPPSQQQIPNQPIGVGLNGQLGVGMGFPSQLPNQPQQQQQRQQPQQQPQIPQPQQQQQQQQQQRIVSDGSQYNLPQGQQGNQYANTLSQLEALQQMKERQQRSGLKTPQMPQPNLPISSPQQPTPNVNVGQNALGVNMNPNFQMMQQNVPQQSQQQRVTPQMNQPQLAPTQPRPQTQSQAVSNTNQTPQLQNQTPNMASGSMAPPSTTNTGGSSKFQYFDQIPTWNNEKLISATTTIAKRLIDGMQNGSSTTVNEQMSKFHLLLLIAEVKKRNIIIPQDAINVAAAFMNVPNPVQALMSMEAPMLLTIAQSNITRLLSGHNQAQAQAAQSQQAQPPQPQQQQIQQPQHARQRSYQGQPNQQGSQNNPIELITPTMNQMNLPQQFSTPVQQNIAPQQQQQQFAPSNQQQQQQWAQQQQLQQQQQSQAQQGSQLQQNQQNQPSAPQPPTMGLESLNLPEESFWHSLRQIHSTQNVQNPVVEGKQVNLYKLFQIVLKNNGSAKIDNPRWTFVAGQLGFASEPGQPGQPPSSSPSVANQIRSCYAQMLQPLENLFMARIQQRRQNVGQQQQQQTQQQQQQQPQVVNPSPSLQQSQLTQSQSQSQSQVPQLSEQQRRFLEAAKNAGSSAAGPGTGTLEGLAQQVTGQHTPQQSQQTPQNQPQQDQQQQQGSVNGIKGNPLKIYEFIKSQEAQVRAKLDRNPSIPSVDKEAYRTELASLMPIIKEAENRVPMFLMMMQEMGAPEMSAGPQIVSMYTSALYANSAAESDRFILNVSDLHRIKIGLAQLMARAQSMYRAMLDKPGGQALLRTIASALNSAKISLGGSGSVFTSQAPPQAPLTGSGNQPSALAQQANSPANLAEAIAARHKSLRVEDLKPPPAKRSKGSKGSPATPSGSGTVQTPEAKTPTESPGSAKRPNISQSGGKRKRQSSTVTSTAATALQNATGGKTPRQLMAEVKESMLKSKIPLGQLSGNNLNLPGNINALGIDLSPNELVGQVELDQNKNFFDNQHNLSLAAGILPYNSQLSVQSQTNEQDLLSGLSLDTWQIFSQAYEAFRASQVDANSGQDQAQPNLRGTIGISTNTSSNGNNMINDNSTKTSGTDDIFEQYLDVTQLAEEFPTPELYRSNSILSLSKETPESDNSPESIKTVASTSVPIIPNDTTTKQSTSQSLDKMNEITSDAAGVLNGQLSDINPEGDLGDLNGINQWNSFSSEGLMYGSEESRFYNGAISW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MMF1</accession>
    <name>A0AAJ8MMF1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_101429</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008913.2">
        <property type="nucleotide sequence ID" value="XM_019158300.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MMF1"/>
    <dbReference type="GeneID" id="30174969"/>
    <dbReference type="KEGG" id="kpin:30174969"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000106">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF65">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="473"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="503"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="103"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC67521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="562" mass="63943" checksum="682B463B445005BD" modified="2024-07-24" version="1">MAIPAPPVSVNPQLTETITPALPHHPAPSSPESYDSAKKESEYISQDGEITYGYGTANSSQDELYAKWYEPPDSYESKHRWDPKANWTKEEENKLRRRLDLKVAFVACLCFAALQLDRGNISNALSDNLLTDVGMTTKDYNNGMTIFYLCFLSAELPSQMISKKLGSDIWIPIQMMLWSVVAIAQVGINGRSSFYATRALLGLLEGGFIADTILYLSYYYTAAELTIRLSFFWISYTATNVIGALLAAGLLKLRGHKGLPGWKWLFLIEGIVTFVIGAWAFFYLPASPTQTKKWWRPKGWFTEREEIIIVNKVLRDDPTKSSMHNREGLSLIDLWRSLTDFDMWPLYLIGLVAFITPSTVQAYFTLTLKHLKYTTLQTNLLTIPSWILFAIGNFSCAYGAKKLNSRLFFILVQPIWHLIFMIILIVLPDNTNRWSKYIILTLVQGYPYCHPILVSMNSMNAGSVRTRTVASSLYNMFVQSASLIASNVYQPSDSPYYHKGNKVLAGLSATSILLVLFAKVWYIYRNKQKSKIWDNFTTAEKEDYLANTTDKGNKRLDFRFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MP93</accession>
    <name>A0AAJ8MP93_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal protein L37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_102318</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic ribosomal protein eL37 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058642.1">
        <property type="nucleotide sequence ID" value="XM_070202541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MP93"/>
    <dbReference type="GeneID" id="30176057"/>
    <dbReference type="KEGG" id="kpin:30176057"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.30:FF:000001">
        <property type="entry name" value="Ribosomal protein L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00547">
        <property type="entry name" value="Ribosomal_eL37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001569">
        <property type="entry name" value="Ribosomal_eL37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018267">
        <property type="entry name" value="Ribosomal_eL37_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01907">
        <property type="entry name" value="Ribosomal_L37e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01077">
        <property type="entry name" value="RIBOSOMAL_L37E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 9 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 9" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC68392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="93" mass="10481" checksum="E074ADD5DDC5D396" modified="2024-07-24" version="1">MSKGTPSFGKRHSKSHTLCRRCGQRSFHKQKHTCAQCGYPAAKLRSFNWGLKAKRRKTTGTGRHAHLKDVNRRFKNGFREGGAAPKKVKATSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MQ88</accession>
    <name>A0AAJ8MQ88_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_103366</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058837.1">
        <property type="nucleotide sequence ID" value="XM_070202736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MQ88"/>
    <dbReference type="GeneID" id="30169998"/>
    <dbReference type="KEGG" id="kpin:30169998"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_uS14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836:SF19">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US14M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC69427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="97" mass="10661" checksum="C0442FB4C006C5C3" modified="2024-07-24" version="1">MGAKAQVLRDIRKRLSAEQFEVQRRAYLFVARNTTLPATVRHKAQLGLNALNGGEGRLGAVKSRCWETGKGRGVMSKFGLARVTLNGELPGVHKSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MQD3</accession>
    <name>A0AAJ8MQD3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_103968</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011146.2">
        <property type="nucleotide sequence ID" value="XM_019156188.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MQD3"/>
    <dbReference type="GeneID" id="30172827"/>
    <dbReference type="KEGG" id="kpin:30172827"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="19"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC70024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="383" mass="41806" checksum="71FD001E20D89930" modified="2024-07-24" version="1">MTKSYTQLGDEILVWKLMGIEKLQQESRNGPTPPGPYEAIIAPQWNGLCGSDMHIYLTALLGEEKMKEPFVLGHEASGIVVEIGNQVRRLTIGDKVAIEPGEGCGRCGDCKKGAYNHCDYMKFAAADGRDGTLQGLYKLPADLCYKLPDNLSLEEGALMEPLAVAVNAITNIANLPHSANVVVFGAGPVGLLTMAVAKALGARRIIAIDVQKERLDFAKTYLAADIHVASPMKENETKESYSQWHADLIKDSLGMTDRGIESIDLVIDCSAAEVCMQTGLWLLKRKGTYVQVGCGPLYVKLPMRIIADRELIVKGCFRYGPGVYPMAIDLVSRGLIDLKPLITHKFKWEEAVKAFETTKVGKGDDGKMAIKVMIGPPPRIRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MQY6</accession>
    <name>A0AAJ8MQY6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_104110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059002.1">
        <property type="nucleotide sequence ID" value="XM_070202901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MQY6"/>
    <dbReference type="GeneID" id="30172683"/>
    <dbReference type="KEGG" id="kpin:30172683"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC70162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="150" mass="17584" checksum="1B79F3460940DF43" modified="2024-07-24" version="1">MMKKLLKKRGQGSQYGYHQTLPPQTPERQEYARAIAADVGNMDEQWDIYYHAFLLHRCKHSQCYWYRNTWWFPETGRNVDTLSMFSASRYPPQENIKYYNMHLPNGKMLENGSRYIGPNTAEEGWLGDYVGYNLNLVTFDMKPIPSGGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MRW2</accession>
    <name>A0AAJ8MRW2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Spliceosomal protein DIB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_106131</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Essential role in pre-mRNA splicing. Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DIM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010486.2">
        <property type="nucleotide sequence ID" value="XM_019156684.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MRW2"/>
    <dbReference type="GeneID" id="30173325"/>
    <dbReference type="KEGG" id="kpin:30173325"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02954">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000004">
        <property type="entry name" value="Spliceosomal protein DIB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004123">
        <property type="entry name" value="Dim1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052:SF5">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEN 4A, 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02966">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017199">
        <property type="entry name" value="mRNA_splic_U5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01410">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC72171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="143" mass="16614" checksum="53F54D925847A1BB" modified="2024-07-24" version="1">MSYFMTHLHSGWHVDQAILVEEDRVVCIRFGHDHDPECMAIDETLYGVSEKVQNFAVIYLVDITEVPDFNKMYELYDNSSLMFFYRNKHIMIDLGTGDNNKINWAITDKQELIDIIETVYRGASKGRGLVVSPRDYSTRQKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HS90</accession>
    <name>A0A1B9HS90_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_07927</name>
        <name evidence="5" type="ORF">I206_106539</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="OCF46142.1"/>
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        <property type="protein sequence ID" value="WWC72577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_019159611.1"/>
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    <dbReference type="KEGG" id="kpin:30176296"/>
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        <property type="component" value="Chromosome 9"/>
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        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
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        <property type="entry name" value="Sec7_C_sf"/>
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    <dbReference type="PANTHER" id="PTHR10663:SF405">
        <property type="entry name" value="ARF GUANINE NUCLEOTIDE EXCHANGE FACTOR SYT1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00233">
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HS95</accession>
    <name>A0A1B9HS95_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar protein sorting-associated protein 28</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ESCRT-I complex subunit VPS28</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_07903</name>
        <name evidence="10" type="ORF">I206_106516</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the VPS28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700120">
        <property type="protein sequence ID" value="OCF46118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007337.1">
        <property type="nucleotide sequence ID" value="XM_019159587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HS95"/>
    <dbReference type="STRING" id="1296096.A0A1B9HS95"/>
    <dbReference type="GeneID" id="30176272"/>
    <dbReference type="KEGG" id="kpin:30176272"/>
    <dbReference type="OrthoDB" id="2671at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.200:FF:000004">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1130:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 28 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007143">
        <property type="entry name" value="Vps28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017899">
        <property type="entry name" value="VPS28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037206">
        <property type="entry name" value="VPS28_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017898">
        <property type="entry name" value="VPS28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038358">
        <property type="entry name" value="VPS28_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 28, ISOFORM 2 VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03997">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017535">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140427">
        <property type="entry name" value="VPS28 C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51310">
        <property type="entry name" value="VPS28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51313">
        <property type="entry name" value="VPS28_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0967">Endosome</keyword>
    <keyword evidence="4 5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS28 N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="VPS28 C-terminal" evidence="7">
        <location>
            <begin position="113"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCF46118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC72554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="213" mass="24087" checksum="40FFBB22A33850E2" modified="2016-11-02" version="1">MMNLDEEVRLWTTNAEREKTENLATLYSIIVSLEYLERAYVRDSVNGKEYAPACIKLLAQYKSLMKLVGNDIGGVEAFMTRFKMDHPAALHRLTIGVPATVEHSSEATDGGAEAGKWVAETTQSFITFMDALKLNLKAKDQLHPFLTDLMSGYSRFKGSGEWEGRGKILHWLITLNAMKASDEITEEQSRQMLFDIENAYNEFFRSLSSNKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HSG8</accession>
    <name>A0A1B9HSG8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">leucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I206_07894</name>
        <name evidence="15" type="ORF">I206_100079</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="2"/>
    <dbReference type="EMBL" id="KV700119">
        <property type="protein sequence ID" value="OCF46223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007442.1">
        <property type="nucleotide sequence ID" value="XM_019159578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HSG8"/>
    <dbReference type="STRING" id="1296096.A0A1B9HSG8"/>
    <dbReference type="GeneID" id="30176263"/>
    <dbReference type="KEGG" id="kpin:30176263"/>
    <dbReference type="OrthoDB" id="10249672at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07959">
        <property type="entry name" value="Anticodon_Ia_Leu_AEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000001">
        <property type="entry name" value="Leucine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004493">
        <property type="entry name" value="Leu-tRNA-synth_Ia_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055416">
        <property type="entry name" value="RBD_LARS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00395">
        <property type="entry name" value="leuS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794:SF1">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24810">
        <property type="entry name" value="RBD_LARS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="67"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="227"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="12">
        <location>
            <begin position="832"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine--tRNA ligase RagD-binding" evidence="13">
        <location>
            <begin position="986"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="150"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF24810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCF46223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WWC66178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1126" mass="127762" checksum="3AA4A677D9E2AB54" modified="2016-11-02" version="1">MAAAVNHDAKAGSVVVMEKTDKRDYLIALESSAQKSWSTSQSFEANPPPLPEGIKSYADFFASGQSMEELQKKYPKWFGTFPYAYMNGSLHLGHAFTISKIEFAAGFERMRGKKVLFPVGYHATGMPIKAASDKLIREMELFGEDFSGYKEDTEEDSSTSAPPVPTTTALPAKSLESTDPSKGKKGKLNAKSTGLTYQFQILELIGVPREELKKFADPYYWLTYFPPIAKEDLTGLGARVDWRRQFLTTEANPYYDSFVRWQMNKLYQQGKVKFGKRYTIYSPKDGQPCMDHDRQSGEAVNPQEYTAVKMEVLEWGPEVTSEVKQAVGGKKVWMVAATLRPETMYGQTNCFVGPTLKYGLFESAHNELYLITERAARNMAFQGIFEGESGRVEKVADVIGSELLGTKVAPPFGIAKEVYVLPMEGVLATKGTGVVTSVPSDSPDDYRTLMDLRKKAEMYKIKPEWAAVDPIPVLKTPKYGDMAAEFLCNELKIQSQRDKDKLAEAKDLTYKEGFYNGVMVIGDFKGETVQDAKPKVRQQMIDAGLATAYAEPESEVISRSADVCVVALVDQWYLDYGEDSWKASAFKLLEQMNTYQTETRNAFEAVLNWLNKWACARSYGLGSKLPWDPVWLVESLSDSTIYMSYYTIANLLHEDMFGKNPGPLGIKPEQMTDEVWEYVLGSGELPENSPVEAEKAAQLKYHFSYFYPVDVRSSGKDLIPNHLTFWIYVHAALFPEKQWPRAVRTNGHLMLNGKKMSKSTGNFLTMREATKKYGADAARFTLADAGDDITDANFEETVANAAILRLHTACLWAEEMKSIESTLRTGEFNEFDKGFQAEMDALIESTYKYFDQMEFKSALKSGLYDFENARNWYRLISDPSNGGQGMHKEMVFKWIRNNTLLITPFTPHYSEHIWKNVLGEKTDIQQAKFPKISKPIEKSILEQNEYMKQVVDKLRSAESNLNKKKGKGKSTTTYDSNKPKQTRIYVAENYPEWQEKVIDLIKKSYNLNGIKEINEIKLRELLSESGLIKDKKVMPFVQQIKKKLQIEGEDAFERSLSFNELNTLKILIPYIKSSAKFTNVEVISINEIKENLKNNNKEELSNKENYDLIKIENSQPGLPEVQFWNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HSK8</accession>
    <name>A0A1B9HSK8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_07733</name>
        <name evidence="9" type="ORF">I206_103784</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700118">
        <property type="protein sequence ID" value="OCF46256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC69841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007475.1">
        <property type="nucleotide sequence ID" value="XM_019159423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HSK8"/>
    <dbReference type="STRING" id="1296096.A0A1B9HSK8"/>
    <dbReference type="GeneID" id="30176102"/>
    <dbReference type="KEGG" id="kpin:30176102"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF172">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="7">
        <location>
            <begin position="39"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="6">
        <location>
            <begin position="219"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF46256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC69841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="44837" checksum="EF19FCA43441B5A4" modified="2016-11-02" version="1">MSHIPSTFQPPSTEGKPSVPVWQPPPATKENHDFAKLTTIDLALLDSPDSSIVSNLVATTKQAIKEDGFLYLVNYGVSIEQLHRQFAIAQYLHRNISEEDKERLLWDPATGLFAGYKPGFGWKREKGAIDGIEHFNFYHEQFSDINNIPTCIHPFMDEIVAFCEFLTQSVNRRLLRLLSKVLELDEDFLWDRVQSQKGPVGEGYLRHALFHPLQEDTKKLGGGLRMNGHQDYGTTTLLFSVPISCLQIWGNDDKWRYVGYNPGSLVVNLGETLEIISGGHFKATRHRVYQPPADQAHEQRLSLVLFNAAEGSLRVSPAMESPLLQREGCVNEQGVYNGFKTLMDNGMPVPTMKEWREIQIATLPEPNLKNEMKFVEVNGKTMYQRDLFGIPVVIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HT95</accession>
    <name>A0A1B9HT95_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_07340</name>
        <name evidence="7" type="ORF">I206_106772</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894016">
        <property type="protein sequence ID" value="OCF46487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007706.1">
        <property type="nucleotide sequence ID" value="XM_019159034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HT95"/>
    <dbReference type="STRING" id="1296096.A0A1B9HT95"/>
    <dbReference type="GeneID" id="30175709"/>
    <dbReference type="KEGG" id="kpin:30175709"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="27"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="4">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCF46487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC72808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="312" mass="34958" checksum="B09CD199BBCFD01A" modified="2016-11-02" version="1">MTITKPPTYFKLPSGDKFPSVGLGCWQSEPGALSKAVAYAIKVGYRHIDGATIYGNEKALGEGLRRSGVDRKDIWVTTKLWNDDHRPEDVMKACKRSLELLGLDYIDLWLMHYPAATDTNPKDPMDIRVLDISYLDTWKAMEECLDAGLVRNIGISNYSKIEVGNLLNNCRIKPAVHQIERHPYLPQNAFMKYHEEIGLHVTAYSPLGNTNPSFSERDSLPPIQKNPAVQALASKYNISTANVLISLQLSEGCSVLPKSVTPSRIEENLRVVQLTAEDIDTIKSTTQGQRARYCDFSDIIGYKYYVGLDDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HTD4</accession>
    <name>A0A1B9HTD4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Allantoin permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_07386</name>
        <name evidence="9" type="ORF">I206_106725</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894016">
        <property type="protein sequence ID" value="OCF46533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007752.1">
        <property type="nucleotide sequence ID" value="XM_019159080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HTD4"/>
    <dbReference type="GeneID" id="30175755"/>
    <dbReference type="KEGG" id="kpin:30175755"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000001">
        <property type="entry name" value="Uracil permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF0">
        <property type="entry name" value="PURINE-URACIL PERMEASE NCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="522"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="538"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF46533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC72761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="556" mass="61627" checksum="2FCB4307457FADD6" modified="2016-11-02" version="1">MLDFVKNIEPKRWLTRDYWYLDTPPASYATRDGWSNADVDVVPVEQRNWRAVNYLFLWLSDGANVGTMQQAGSIVAMGLSWREASGAIAIGNIIIAFAVALNGTIGSRHHIPFSIASRASLGFYFSYFAVFSRLVLGLIYFGINTFIGASCTLICLEAIWPSLKTYPNSIPVSQGVTSSKMIAYFVFWTIQFPLVLIHPRKMRWLFFVKSIVAVIAAFATLGWAVHRAGGSGPVFAKHTTLTGATRSWAWVAGINVAISGKTTLAINIPDLTRYAHRTSDSYWQLLFIPIVYFIFSFIGIVIASAGQAIYGQLYWDPTMIIAQWTSRAGAFFVAFAFALATLGTNISTNSIAASNDFAFLAPKWLNIRRGAFITAILGGWVTCPWKIQASAKALTTFLSGYIIVLAPIVAIMIVDYWIVRKTRFHVPMLYQNEGIYKYHYGTNWRALVTLLIAVPVNLPGLINAINSKVDIGKYSFFYKASWLTSTAMGASIYLLLSTLFPPTSTLVDHTVESMDEDYALSDPQAWETDQDKEKRTSAGGSQETGEPSSFPVFNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HTJ5</accession>
    <name>A0A1B9HTJ5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_07433</name>
        <name evidence="3" type="ORF">I206_106677</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Pearson M."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
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                <person name="Young S.K."/>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="Young S.K."/>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
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                <person name="Zeng Q."/>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
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    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="11">CBS 10737</strain>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YAE1 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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        <property type="entry name" value="Yae1-like"/>
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    <dbReference type="PANTHER" id="PTHR18829">
        <property type="entry name" value="PROTEIN YAE1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18829:SF0">
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        <property type="entry name" value="Yae1_N"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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            <dbReference type="Pfam" id="PF09811"/>
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    </evidence>
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    </evidence>
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    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">First step of mRNA capping. Converts the 5'-triphosphate end of a nascent mRNA chain into a diphosphate end.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67004"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
            <dbReference type="EC" id="3.6.1.74"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:67005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the fungal TPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.74" evidence="8"/>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008932.1">
        <property type="nucleotide sequence ID" value="XM_019158319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HWR0"/>
    <dbReference type="STRING" id="1296096.A0A1B9HWR0"/>
    <dbReference type="GeneID" id="30174988"/>
    <dbReference type="KEGG" id="kpin:30174988"/>
    <dbReference type="OrthoDB" id="272147at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031533">
        <property type="term" value="C:mRNA capping enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140818">
        <property type="term" value="F:mRNA 5'-triphosphate monophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004651">
        <property type="term" value="F:polynucleotide 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07470">
        <property type="entry name" value="CYTH-like_mRNA_RTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.10">
        <property type="entry name" value="mRNA triphosphatase Cet1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040343">
        <property type="entry name" value="Cet1/Ctl1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004206">
        <property type="entry name" value="mRNA_triPase_Cet1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037009">
        <property type="entry name" value="mRNA_triPase_Cet1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118:SF1">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE CTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02940">
        <property type="entry name" value="mRNA_triPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="4 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="mRNA triphosphatase Cet1-like" evidence="10">
        <location>
            <begin position="119"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCF47713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC67503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="368" mass="41099" checksum="9529032A7DF6DEF0" modified="2016-11-02" version="1">MAPYVPLHDRSPYFSNLPTPPYSRDPPTPRYASPDYDPSLPLHPGSQLDMSSTSTPDYHNEYNTNNGSSTYAPRSTEGEAGPSRKRARPEEYTDHHIQQYHNAGPVRLTGSIFNIAPRNPFTAVVGDFIMANAAGLDNVEIEIKLGILMSPDHQGNPQRRIRMPTQSEMIVPPDYPLGPFHATMHPYQHKVLNNLLNQAAQQSVSLPPEQGRVNFSRSKLTDSFHGQGGRGGKIRVSRSRETGEVVEVVKKRRIADMNVFCPGAAFDWRISVNVEEPYDMPDSPPTMTRDKDRASYRHQVCQVDLTHVMSKENAQAKAVSSFELEIELLDVPTLLAEGQAQSDRFDEILQNALDTARMLVKNCDPAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HXB3</accession>
    <name>A0A1B9HXB3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_05770</name>
        <name evidence="3" type="ORF">I206_107442</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894014">
        <property type="protein sequence ID" value="OCF47906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009125.1">
        <property type="nucleotide sequence ID" value="XM_019157485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HXB3"/>
    <dbReference type="STRING" id="1296096.A0A1B9HXB3"/>
    <dbReference type="GeneID" id="30174139"/>
    <dbReference type="KEGG" id="kpin:30174139"/>
    <dbReference type="OrthoDB" id="2554293at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="863"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="869"/>
            <end position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF47906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC73472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="914" mass="103189" checksum="88552C7D86CF242E" modified="2016-11-02" version="1">MLRRIRAKLLSNPVRPPLTLPSFRLSSSAALARCQESEEDQLVPYGLDYGAGPSRIPYQPPHVHIPPTSLESTSSRLTVRNLREILRNVKPGAYAQPKIFMKTIFNHSQSWSQPKNIHYSQDIASISRIELHTIVHHLIRRKKGNTAAALIRDVLALSSREKRRRLLSIKTVSTLFRDRSAYNMFKAQSLGGIANAAPDLSPNFESQIALPPSRALATLLNILDLLQDVRYNRPLELYSLIIKQCVDEQLYDLAAKVYVGLVEEWVTEGRVAHGANPDDFHPGGGPPRAQGDQPLSKLLGHWWTGVRTWRLPGEILSPHDRLDLWHPKQLSLGEKMKNFPLPIATSPPSLVPQPKTVLLNTIISSLTLDPEACSPREFASSMRALAILANTVLSRTLPIVSLGRLLQAFKTAPNKPDVYPENVSEIPSENQWAYTSFTQIHVTLMSLLFSPPISSHSMQLIAENQDLQHEEGLTSPNHDQAMNQYMMPPLSWKSCTILLRYAFESLRKPFLLKRLLRYMKDVFSMGAENPQAFNTLLKGASALQLNAIAAQSDQAIFGEQKYDRPSHAPPPKPESRFFSSTQRIARKRTKHNKEEEDLGGFIQTEFELGTSPLPDQNSLLALIKHLTVTSQFIRLESLVYILEPYLEFSKNMSPAEVQSRLQKRRLEPGISGRPKSQGIPYDVYVALLKGLEKAGSTGLAQRVFNLAMYAEKENINDFFETNPEGILPSSLKFPLEGFKVMLDVWGNESRFTNRSSNGIGDQVPIGWELPQGYKRLPRGVAAGYMTMVTHHLAKKSYSPENFNEEYYNSLLKACKWRWKLSEDEQLFRGFRNEMKNICQDIEDSNLQIPEVLLAKLTGQTSNSSQKWNRQVKRNRSKKSKQTAEEELLNKLLAGEPLSVVNEDYAKSSNEVRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HXE4</accession>
    <name>A0A1B9HXE4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">rRNA-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_05801</name>
        <name evidence="11" type="ORF">I206_107472</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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                <person name="Heitman J."/>
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                <person name="Gargeya S."/>
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                <person name="Imamovic A."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
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                <person name="Birren B."/>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
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                <person name="Young S.K."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="14" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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    <reference evidence="13" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894014">
        <property type="protein sequence ID" value="OCF48184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009403.1">
        <property type="nucleotide sequence ID" value="XM_019157763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HY45"/>
    <dbReference type="STRING" id="1296096.A0A1B9HY45"/>
    <dbReference type="GeneID" id="30174421"/>
    <dbReference type="KEGG" id="kpin:30174421"/>
    <dbReference type="OrthoDB" id="204711at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005469">
        <property type="term" value="F:succinate:fumarate antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000021">
        <property type="entry name" value="SFC1p Mitochondrial succinate-fumarate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF2">
        <property type="entry name" value="SUCCINATE_FUMARATE MITOCHONDRIAL TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="28"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="129"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="234"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCF48184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WWC73746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="338" mass="36751" checksum="2B0B0344592E8277" modified="2016-11-02" version="1">MSSSTSKPRGGGASGDRISNPANIKEKIPLSTHLIAGGIAGLAEATVCHPLDTIKVRMQLSKSRKLKGLKPLGFFATGRQIAARETPLGLYKGLGAVISGIVPKMAIRFASFETYKGWLSNSDGKISPSSTFLAGLGAGATEAIAVVTPMEVIKIRLQAQQHSLADPLDIPRYRNAAHAAFTIIKEEGFQTLYRGVSLTALRQATNQGVNFTAYQQFKKFAFDFQPKYKELNNLPSWQTMILGLISGAMGPFSNAPIDTIKTRIQKASHVPGETSMSRFLKVSSEMFKNEGAKAFYKGITPRVLRVAPGQAIVFTVYERVKKWIDYTKGSNIGAEYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HY59</accession>
    <name>A0A1B9HY59_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Phosphoribosylaminoimidazole carboxylase</fullName>
            <ecNumber evidence="4 11">4.1.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I206_06087</name>
        <name evidence="15" type="ORF">I206_107754</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2</text>
            <dbReference type="Rhea" id="RHEA:10792"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="EC" id="4.1.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.21" evidence="4 11"/>
    <dbReference type="EMBL" id="KI894014">
        <property type="protein sequence ID" value="OCF48219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009438.1">
        <property type="nucleotide sequence ID" value="XM_019157798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HY59"/>
    <dbReference type="STRING" id="1296096.A0A1B9HY59"/>
    <dbReference type="GeneID" id="30174456"/>
    <dbReference type="KEGG" id="kpin:30174456"/>
    <dbReference type="OrthoDB" id="15425at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000013">
        <property type="entry name" value="Phosphoribosylaminoimidazole carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000037">
        <property type="entry name" value="Phosphoribosylaminoimidazole carboxylase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01928">
        <property type="entry name" value="PurK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016301">
        <property type="entry name" value="Ade2_fungi/plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005875">
        <property type="entry name" value="PurK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054350">
        <property type="entry name" value="PurT/PurK_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004679">
        <property type="entry name" value="PRK06019.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01161">
        <property type="entry name" value="purK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11609:SF5">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11609">
        <property type="entry name" value="PURINE BIOSYNTHESIS PROTEIN 6/7, PUR6/7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22660">
        <property type="entry name" value="RS_preATP-grasp-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001340">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52255">
        <property type="entry name" value="N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
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    <proteinExistence type="inferred from homology"/>
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        <source>
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    <sequence length="584" mass="63585" checksum="20AB7408CB956AD9" modified="2016-11-02" version="1">MAPQKTVGILGGGQLGRMLTHPAALLGIPLLILDSGSYTPAKQTLLPPENQQGHLDGPFTSEPHIRELAKKCDILTVEIEHVNADVLEAVEKEGLCEVQPSPSTIRLIQDKFQQKKYLSERGIPVSPFDELPSNPTENDFKNLTDKLGLPVMLKAKTLAYDGRGNSPLKSTSSEDIKKSLDFLGDRPLYAEGWCSFVKEVAVMVVRNKEGQVKSYDAVETIHRDSILRVCLAPLRGDQSLNARARQLAESAVGHLTGAGIFGVEMFLMEDGSLLLNEIAPRPHNSGHHTIEACNTSQFENHLRAILSLPLGSTDLIVPSAAMVNILGSSSEMGPIEAMRDNALSVKGATIHLYGKKESRKARKMGHITLTAENDAELTENLRKILFSQPDSNSEWIDKIAPPNPLENHSHKKPLIGIIMGSDSDLPIMLPATKILNQFKIPYELTITSAHRTPEKMIKYSKSASNRGLRVIIAGAGGAAHLPGMVASETVLPVIGVPVKASVLDGVDSLYSIVQMPRGIPCATVGINNSTNAALLAIKILGTAIPKYQIALEEYSKKLEEEVLQKCEKLEVDGWEKYVKETLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HY60</accession>
    <name>A0A1B9HY60_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_06072</name>
        <name evidence="5" type="ORF">I206_107738</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="OCF48204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC73766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_019157783.1"/>
    </dbReference>
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    <dbReference type="STRING" id="1296096.A0A1B9HY60"/>
    <dbReference type="GeneID" id="30174441"/>
    <dbReference type="KEGG" id="kpin:30174441"/>
    <dbReference type="OrthoDB" id="21470at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
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    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="FHA_dom"/>
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    </dbReference>
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        <property type="entry name" value="SMAD_FHA_dom_sf"/>
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    <dbReference type="PANTHER" id="PTHR23106">
        <property type="entry name" value="ANGIOGENIC FACTOR WITH G PATCH AND FHA DOMAINS 1"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="3">
        <location>
            <begin position="433"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
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        </location>
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        </location>
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        </location>
    </feature>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF48204.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC73766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="56596" checksum="EEBD581E492D7A5B" modified="2016-11-02" version="1">MANTSPSEDTWIYDHLHKSYFHPLSNTYAIPDPNTAQWNYIPADQVHNASTSATNSGYNNSTIVGSEKEEGEIEDDMGWGGLMEPEKLAQIEKDEKIKPMKSTKQPLHPTVPPEKEKHPAYVVPYDDPALYAYPSQPEGDEADQEKPTKERPNDTLRLVVMGSGCLEVGQVAILDTREGGIQLGRDRCEKGGQARVRLKEMEVSKTHAVIYWGTGGDDESSQVEELQDWWIVDLGSTHGTFLSQPMTEDATRTPKLTRLSEPKHSSRPHRVTHLSRLRIGTSEFSLHIHPSWPCDQCQVNGTNEIPLDDGQPKLIPAHNEEVASENDTPPIYAMDSSQKKQNRELKRKREMASLRESLLRKDRGIHVNGRSEGDQEDSRKREYLDRSAMRRKLHPPSPPPHSTKGNTKMASEANTPERSSPPVSIQTPDASKGTFIATSIMEKQGWTPGMGLGKSSQGISEAIQTEMRNEKKGLGAKGSKAIVNTGPGDWKMRAKQRRWEEMQGSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HZ51</accession>
    <name>A0A1B9HZ51_9TREE</name>
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        <recommendedName>
            <fullName evidence="6">TMEM205-like domain-containing protein</fullName>
        </recommendedName>
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    <gene>
        <name evidence="7" type="ORF">I206_05290</name>
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    </gene>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
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            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
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                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        </source>
    </reference>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Abouelleil A."/>
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                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
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                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
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    <reference evidence="3" key="2">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="Sun S."/>
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                <person name="Litvintseva A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
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                <person name="Zeng Q."/>
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                <person name="David-Palma M."/>
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                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
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                <person name="Yurkov A.M."/>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Sun S."/>
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                <person name="Young S.K."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
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                <person name="Shea T."/>
                <person name="Bowers K."/>
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                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF48958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC71866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="281" mass="32017" checksum="3696C3495762C617" modified="2016-11-02" version="1">MTGITMPKMMYGTAWKKERTTELVIQAIKSGFRGIDTACQPKRECREDLVGQALKTLFAEGVVSREDLFIQTKFTSIDGQDKNQPLPYDPKLTIPEQVEQSFQTSLKNLGVDYIDSVILHSPLKTKEQTLSAYQTLESFVDEGKIHNLGVSNIYDSNLLSWLIEKSRIKVGVVQNRWYEGNGWDWAVWEICQKNNIRYQSFWTLTGSPSLLQHPHLINMASKYGLTPEQTIYKLCQLWNITPLCGSKTLSHINEVLAVESAIGMKEDTLEVQQLWNAMHAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I0L4</accession>
    <name>A0A1B9I0L4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_04742</name>
        <name evidence="9" type="ORF">I206_105919</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC71960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010274.1">
        <property type="nucleotide sequence ID" value="XM_019156472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I0L4"/>
    <dbReference type="STRING" id="1296096.A0A1B9I0L4"/>
    <dbReference type="GeneID" id="30173111"/>
    <dbReference type="KEGG" id="kpin:30173111"/>
    <dbReference type="OrthoDB" id="18915at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22749">
        <property type="entry name" value="Otubain_C65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.60">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.20">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019400">
        <property type="entry name" value="Peptidase_C65_otubain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042468">
        <property type="entry name" value="Peptidase_C65_otubain_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042467">
        <property type="entry name" value="Peptidase_C65_otubain_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931:SF15">
        <property type="entry name" value="UBIQUITIN THIOESTERASE OTUBAIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931">
        <property type="entry name" value="UBIQUITIN THIOLESTERASE PROTEIN OTUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10275">
        <property type="entry name" value="Peptidase_C65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="OTU" evidence="7">
        <location>
            <begin position="86"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF49055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC71960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="302" mass="34157" checksum="13F8EAF0194721DC" modified="2016-11-02" version="1">MSTQTETRPSPGTDVQPRVIDENTDLSTLTDQEIMRLMEGMDHQQEQLDKPLISTPVPLSVIRQEYEKGSSMILKKLDWLAQNGWDQVWRARGDGDCFYRSFTLAYLVRILHSSDPQLEANIAYEAIQRALPAMEEVNFQKDLYEEFLDPLLVLIRSFAEGGDDSTSTEYGIVQALQDPERSNCIVVALRLITSSYIRTHSELFSPFLLSPTTFLPLSTDEFCKSEVEPCGKEADHAQIMALAESLNIGIRIAYLDKSDLSTSDAINWVEFGKDTTEQGRPLTLLYRPGHYDVVTKDVLPQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I1L4</accession>
    <name>A0A1B9I1L4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_05107</name>
        <name evidence="4" type="ORF">I206_106281</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010633.1">
        <property type="nucleotide sequence ID" value="XM_019156831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I1L4"/>
    <dbReference type="STRING" id="1296096.A0A1B9I1L4"/>
    <dbReference type="GeneID" id="30173476"/>
    <dbReference type="KEGG" id="kpin:30173476"/>
    <dbReference type="OrthoDB" id="5570013at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF49414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC72319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="709" mass="77589" checksum="D0CD123C0179ACF4" modified="2016-11-02" version="1">MIIPPDPEKDPRLFNPSASTSSLVHPPSEYEDTTSRWDGESLPPYERRRDSRGSLLSQEEHDVFSDQHASSSSRSLPGLIIHNLPTHPEPIHSSSPISSSDSLTPTASRPSLLLPHFTDQASSTLQASGSTSKLWESSTTAIPVKRKSTRICGCIPINNAGFQRWWKKWRRWVQGIVVLIFIGIGLVVGLLVGMSRNEHRGAAGPPWQKPWMDQDTDGKRVAAWSGYGSFNLTYVDSRDGPSPSEGNLTECNNFAPLNTTSSPFVNLFTPYPKSNISLASFSFPLSSAGIPPSDLFVNARGFGSSGHLDFIGSDGPESVISSGEEGKILIDVVVRYSGPQDLTTMMRVCQMTRGDTGVGVGIYSPKETDGKLTNPFKLDPSLIPTNLIIVRLPPSWYSPQSPYSTLPSFSLDADQMVVRLGNLNNVAAFTALNLDTCRGGVQVNYAKAKKASVVAFEGSVRGTWNISESLVVNVTDGSITSDIILSDPKMQMDNTTTLPPISDYTTVVRRIPDGDTPPDNTDVDFENEVHSLFNATSYNPTESNDTRATIVTNLFTTSGYVNLRYLHQPPTIDLYAIIGTQQGNMDISLNPTYIGPLISRTHWGQINLEQPSPVPNYDPSGKARVRQLQVGPIEIKQNTTFGVLGYTQEKLQNSADTLSGYVYWADKNYNGQIVTKTMDELQNDESQQSDNQIIALGNWGDVDISFDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I1S2</accession>
    <name>A0A1B9I1S2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">L-arabinitol 4-dehydrogenase</fullName>
            <ecNumber evidence="8">1.1.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I206_04014</name>
        <name evidence="15" type="ORF">I206_104403</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-arabinitol + NAD(+) = L-xylulose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16381"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17399"/>
            <dbReference type="ChEBI" id="CHEBI:18403"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.12" evidence="8"/>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010712.1">
        <property type="nucleotide sequence ID" value="XM_019155754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I1S2"/>
    <dbReference type="STRING" id="1296096.A0A1B9I1S2"/>
    <dbReference type="GeneID" id="30172383"/>
    <dbReference type="KEGG" id="kpin:30172383"/>
    <dbReference type="OrthoDB" id="2148442at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050019">
        <property type="term" value="F:L-arabinitol 4-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF12">
        <property type="entry name" value="L-ARABINITOL 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="13">
        <location>
            <begin position="85"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="12">
        <location>
            <begin position="239"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCF49493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WWC70452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="411" mass="44985" checksum="EB6F6CE8F467801C" modified="2016-11-02" version="1">MCQSCTPKVNGTIHTATSVESAPQPPLKSQYEIKYDPEIILNDSEFKVLQENDEELKNDKFNIACAYDEKHNIKMIKKPIPKAREGEVIIRVRATGICGSDVHFWKHGQIGPTMIVESTCGAGHESAGEIIELGENVTSLKIGDRVAIEAGIPCGQADCEMCRTGRYNACPRVVFFSTPPYHGTLTRFHAHPAAWVHKLPDNLSYEEGSLCEPLAVALAGLERANVKLGDPVVICGAGPIGLVTLLAARASGCHPIVITDLQESRLEFAKTLIPTVRTCKIERNWSPQETASEIKKKSGTNIKFALECTGFESSITAAIYSVVFGGKVFVIGVGPSEQKYPFGYCSANEIDLQYQYRYSNQYPKAIRLVEGGLIDLKPLVTHRFPLNKAIDAFHVAADPTQGAIKVQIQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I205</accession>
    <name>A0A1B9I205_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycerol-3-phosphate dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="9">1.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_04091</name>
        <name evidence="13" type="ORF">I206_104331</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 9">
            <text>sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="kpin:30172460"/>
    <dbReference type="OrthoDB" id="10263760at2759"/>
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        <property type="component" value="Chromosome 5"/>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:protein homodimerization activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:carbohydrate metabolic process"/>
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        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
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        <property type="entry name" value="6PGD_dom2"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728">
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    <dbReference type="PANTHER" id="PTHR11728:SF8">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(+)]-RELATED"/>
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    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="2 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal" evidence="10">
        <location>
            <begin position="5"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal" evidence="11">
        <location>
            <begin position="195"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="271"/>
            <end position="272"/>
        </location>
        <ligand>
            <name>substrate</name>
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    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
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        <location>
            <position position="298"/>
        </location>
        <ligand>
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            <dbReference type="RuleBase" id="RU361243"/>
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    </evidence>
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            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCF49569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC70381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="344" mass="37942" checksum="6C24B3857325907D" modified="2016-11-02" version="1">MGKEKVAIIGSGNWGSAIAKLAGNNVKKHSDIFDDSKVPIWVFEEDFEGKKLTEIINTEHENKKYLPDVKLSENVVAVPDLVEAVKGATALVFVMPHQFLDKCLDQLEGKVEKNAKAITLIKGVGVEGPDIHVFADVIQERLGVSCSALSGANIANEVAIDRFSETTVGYRTEEEGQLWQKLFQTPNFKVQLIDDVAGVSLCGALKNIVAVAAGFIDGLEYGNNSKAAIMRIGLLEMKYFCQEFFKDVKEESFLQESAGVADVITSCLGGRNRKCAEAFVKQKKPFDELEKDMLNGQKLQGIHTAKDVHIFLKARDRLGAYPLFDKVYQISWEGLPVEKLTEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I247</accession>
    <name>A0A1B9I247_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_04145</name>
        <name evidence="3" type="ORF">I206_104279</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49623.1"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
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            <begin position="10"/>
            <end position="30"/>
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            <begin position="32"/>
            <end position="42"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF49623.1"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="469" mass="53510" checksum="19C9FB4640E46E4A" modified="2016-11-02" version="1">MTNPLPPLSNTPHSESINNADAEGQSSKITESLDDSMFDNDQDVPPISASDDSDSTHAPPPQQLRVPVEILQKIAQYADQPTLAVFMRVSNITYTIASRHLYRQLILTKNNVQKVFIGFPTPMGYRQHQVPGGFQEVRSIYFPGSVYTPVRSYGPFDSDDEEDSFYQETDPHLPSQTYYPTRQTMQRKYLLLNLTRAITIGTKLPTNFCQNIDGWVSHLSPPTGVLLPRLERLIISSQAIKEWADWRDRNLVMSAVAETQDPHFGFLVMLAAPQYMCIRLPTYTIDDWFAFYRSRTQYYSYLPPKELTQHLFMLFRYLAYSEALLIAKDVCEARPSGRPCTSLHNVTNGRVDIEAPPLNIFFSYLLTHPYIAFNYPNFAGNPVVQNFYTRERKYQIRSYLQLLAEGSYLGNRHINMIVPDAEEETVLEEMREFAKELKLNSDATGKGVDCLIWADAAPCSCCSTREGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I2C6</accession>
    <name>A0A1B9I2C6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_04123</name>
        <name evidence="5" type="ORF">I206_104300</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010820.1">
        <property type="nucleotide sequence ID" value="XM_019155862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I2C6"/>
    <dbReference type="STRING" id="1296096.A0A1B9I2C6"/>
    <dbReference type="GeneID" id="30172492"/>
    <dbReference type="KEGG" id="kpin:30172492"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="3">
        <location>
            <begin position="317"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="60"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="337"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="233"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF49601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC70350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="385" mass="42618" checksum="6902D2AEFC2D2137" modified="2016-11-02" version="1">MQTPSMRPRPSSRRHQASSDAKSTDENWDQPLIINAPSRPREFTFVSETPELYTRSRLSNTAVSGVSSPKHLVGAPHNDMRGKKSLATPVTTSREHKLARDTDERLSGDSMQEVLSLPQMQLSIPSFSGTPINSPSTILPDHLKTSPMSTPALRSIPLKCDDPMTSPVRNGSSPLRSRYSEDAPELQTGDSSFSRSGSKPASESDDHSDHRMQFESYHGSDEQEGKTFDQERTLSSSIRARSHSHPAQNSGSYSVKSEQSSSDSSTSSCFSPNNKPKIGQTRSKAKIQQNVAGRSKNVGTSKPRTKGKNGQRRNGERRREQNAVAQKKFRWKKKQQAAKMEAELEVSTALVSTLKKEAVEKDQLIKILKAEVGNLKRRSKNTECD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I2D2</accession>
    <name>A0A1B9I2D2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar protein-sorting-associated protein 36</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ESCRT-II complex subunit VPS36</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_04234</name>
        <name evidence="9" type="ORF">I206_104191</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the endosomal sorting complex required for transport II (ESCRT-II).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the VPS36 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010929.1">
        <property type="nucleotide sequence ID" value="XM_019155971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I2D2"/>
    <dbReference type="STRING" id="1296096.A0A1B9I2D2"/>
    <dbReference type="GeneID" id="30172603"/>
    <dbReference type="KEGG" id="kpin:30172603"/>
    <dbReference type="OrthoDB" id="271448at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021648">
        <property type="entry name" value="GLUE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037855">
        <property type="entry name" value="Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031558">
        <property type="entry name" value="Vps36-NZF-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13128">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13128:SF12">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16988">
        <property type="entry name" value="Vps36-NZF-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11605">
        <property type="entry name" value="Vps36_ESCRT-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51495">
        <property type="entry name" value="GLUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GLUE N-terminal" evidence="7">
        <location>
            <begin position="25"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="188"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF49710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC70241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="615" mass="66011" checksum="5674D6896155B1CA" modified="2016-11-02" version="1">MSHRTPASGLPNGLSADYWSTWIPIRKGSSVSESVDKDVGEQWIGSWDGIGLYEGNNKIPLYQSITVHLTNHRLILIPESTPSTSSSSTPSSLAMYLSYVRQTEFYAGFMRSSAKITLTLGQQTTSSPIAGQETSTSDPIIPEVSQNSGGWTCNICGYVNPLSGNRTTPMPGSKCGLCGIPYSTSQSSVSATPSRSHTPSNSVPHKNISSESSPPSSQNDANISTPNQDGLISCPACTFLNSPLLPNCEICSTPLPKSTRNSSMGKSQNTGLGGSSNLVESLRQDVVRLSFRKGGEKEAYKKLKAVLSDKAWERDIGGSSSLTSKLKRGTGDVVDGVPRSGAGIDGILQQIDLNSKSQSSQVSEAFADLEALMLRAGEMVKLAQNINARLTTQLASNPAGVQQPTEEETTMIRSSLVQLGLAAPAITKEMMRDEQRYHQGLAKELGELLTGRISDRVQGGGEGLMIGRNGRGVIALDEVWGLWMRARGVSLLPPSTLISILPHVPTHTSPTIKSLILPSSLQVLHTPHYSTPAILSRTLDRLCPLDSDEVEKSFTSLEFSDYESLPIGLAKEFIEIMEKTGDNGSGLVRDDQSGLGEGGVRWYRDIISEWPLDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I2F3</accession>
    <name>A0A1B9I2F3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Peroxin/Ferlin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_04254</name>
        <name evidence="10" type="ORF">I206_104171</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010949.1">
        <property type="nucleotide sequence ID" value="XM_019155991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I2F3"/>
    <dbReference type="STRING" id="1296096.A0A1B9I2F3"/>
    <dbReference type="GeneID" id="30172623"/>
    <dbReference type="KEGG" id="kpin:30172623"/>
    <dbReference type="OrthoDB" id="5586090at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006614">
        <property type="entry name" value="Peroxin/Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052646">
        <property type="entry name" value="Peroxisomal_PEX28-32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010482">
        <property type="entry name" value="TECPR1-like_DysF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31679">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31679:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06398">
        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00694">
        <property type="entry name" value="DysFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00693">
        <property type="entry name" value="DysFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxin/Ferlin" evidence="7">
        <location>
            <begin position="294"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxin/Ferlin" evidence="8">
        <location>
            <begin position="537"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="386"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="464"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="386"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="414"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="427"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="465"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCF49730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC70221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="675" mass="73911" checksum="FF8BEB890C6866A7" modified="2016-11-02" version="1">MAPSVSIPQGATTDPPPPVILQSSDLISSLPAPFLRLLVLFARPISLFKSILEILLWRNGNRVPSWMIIGAWWAVCLGSSHAFRFLLPALIFLPFLPLERLRLHSAPKQPTRNTALEPSTSDTLLSTLSDINAIYALLPPSPLPTITAIYDRFRQLGPIRLLRGLVVLWITWIALGHIIGYTTLLGILGSIVLLSPSPPLAHLTNLLSKSLFVRRSLALIFLFIFGSPPETSYHFSISHFSPLGWLKSKWTTSRRPSLAFSFKPKFSGPVASGSAIDDTDNHEEQEGSKKVEKPIYFKFELHENQRWWMGLDWTSALLPNERPSWCDNHLQPVSPPQSFTLPPPSSIITPNPTSEDPNAKVLRTTSWKWLDDDWLIVKQGPGLVNSTSTGNVPSPTIPQDDQGFTVPALQKEGSSSSRPTSFISTFGSSPPSITAEDTLSPGARAQSIAEQAFTKGLERLKARATSINPSATNVTSNSPRKQSADTTSFRARTMSQTSEDSYHTDDPHGQSGNVNVNVQMPMGEVIVDNDDATDNDGWVYGDNKWEGMSAKGGLGKFTRRRRWTRRAVLIESIIKLKSQEPPIIVPSSVSTPIPHDITTGKSKPAPAIAVTVKTTDSLGNKNPNLPTMKMKDNEEEMKNTGVIGTTSLSATGISTQSRDDVLRSRLKKAMGSVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I2S4</accession>
    <name>A0A1B9I2S4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative tyrosine-protein phosphatase OCA1</fullName>
            <ecNumber evidence="1">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_04265</name>
        <name evidence="7" type="ORF">I206_104160</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
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    </evidence>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF49741.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC70210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="475" mass="53558" checksum="A155CA7395B28CCB" modified="2016-11-02" version="1">MLTPPYHFSIVASSITTGNNNDVRNETLYRGSIPTTRNKSFIKRLNLKTVIVLRKKALKEEDDFIRWSKRHKVDVKWIKAEELGEEKLGMGKNEVSDVLKIILDPKLYPIYIADKDGISHTTLIVACLRKLQGWNMDCIINEICRFEPEHEDLPFIPFINSYLSHSSSESLTISNYTNWLWPPIPSNPVASSSKSRDKAPTNSNNINGSLPFPHPLIVRKHPNMKIIFPQPQPQPQPQPQPQTQSQSQNQSIGQSNQIGGISMTSTVISSPTLSPNQGLSRVNSRRDKIQQSGIGNEDHGSSSISQILSNDNDNNNYNIENKEDTKDQLDLNLKENENKLGRTVSFNSITEKEKNSKSQVQVQQSQNSKSITNTSTSISTNQQSNQSSPLKLSREPTFNSSSDQYTSESISTEEGENSIQDYVGEYNDEDDEYYEDDDDEEEEEDDDEEEEEDDDDEGNEPTSQYISALDLAGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I2U8</accession>
    <name>A0A1B9I2U8_9TREE</name>
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        <recommendedName>
            <fullName evidence="2">Origin recognition complex subunit 3 winged helix C-terminal domain-containing protein</fullName>
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    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_04393</name>
        <name evidence="4" type="ORF">I206_104032</name>
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        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011085.1">
        <property type="nucleotide sequence ID" value="XM_019156127.1"/>
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    <dbReference type="Proteomes" id="UP000094020">
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        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:DNA replication initiation"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="ORC_WH_C"/>
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    <dbReference type="PANTHER" id="PTHR12748">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
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        <source>
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    </evidence>
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            <dbReference type="EMBL" id="OCF49866.1"/>
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    </evidence>
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            <dbReference type="EMBL" id="WWC70085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="553" mass="62400" checksum="F4D86B8558575291" modified="2016-11-02" version="1">MEEDNFQSLSKGVFVIPFQNDTQNEAGPSKPCRRPLEKFYDTAYEHYENAYIKYNNDKISEQLDDIQDWLDRCSNSSSNSLLKLKNPIYRLEIGLLQNTSFSSFINSEIHTIGKTCILQGKDINDINQAMKLISLGFMEGDLSNDKNNNNRKNGKSGLDEIKLWYTSQKIKSSLLLYIQDAQMIPSSVLGELMYILSLHPSIPIRLLISVPSISHFLSSWTPIELSSIAPSILSSTTSKKNTGVEAILRASGSAPLQLSDELIDELRSEEAKFGGGPISTLKAIKWLLLHHSINSPLSRLATSSDLIDQKKVQALLNTRLHRPPISNVPGEGLFRIKYNKDLSSVMNPAPRTSILHALSNSEDYIRTNTDLPLRNGEEQHPSSYVETSSQLTNKRQALEPLRSSKRKRIEDEEGVGIGHRDGDDGDIYKGKGEEMKELKMLFELWKNAGKSVNLWDWLEGFHTIMTDCHNNDGDQNKSNEEDDQINEEVIDQNEPIRISEERKQNTTNDDDENESRLHAIFIRFVEEARMIGLIRARGKGKKADEVVKGVGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I346</accession>
    <name>A0A1B9I346_9TREE</name>
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        <submittedName>
            <fullName evidence="7">Membrane protein</fullName>
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        <name evidence="8" type="ORF">I206_103962</name>
    </gene>
    <organism evidence="7">
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011153.1">
        <property type="nucleotide sequence ID" value="XM_019156195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I346"/>
    <dbReference type="STRING" id="1296096.A0A1B9I346"/>
    <dbReference type="GeneID" id="30172834"/>
    <dbReference type="KEGG" id="kpin:30172834"/>
    <dbReference type="OrthoDB" id="5841748at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08022">
        <property type="entry name" value="M28_PSMA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02121">
        <property type="entry name" value="PA_GCPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000008">
        <property type="entry name" value="Glutamate carboxypeptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000101">
        <property type="entry name" value="N-acetylated alpha-linked acidic dipeptidase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF46">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="4">
        <location>
            <begin position="275"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="6">
        <location>
            <begin position="462"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="5">
        <location>
            <begin position="825"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="333"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCF49934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC70018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="912" mass="100369" checksum="EB92BD48D41B3E39" modified="2016-11-02" version="1">MGSKYNNQAHSPSAITLSEKGLSQPNQDELPQPTTTSASSRFSMKQKSMIKHSIFFGVLLFLAIYNSKLLNGRSTSNAISKGFYEDETPIGSYFRGIASKGMRFSLPHPEKSHKHDHHHHDHDHHRKPHKHISPKEAEKIFLSVPNNNSVAAASERYTSYPHRAGSGYDLYSALTLKNEWERELGLKVSGADENVYEAGSAESQNRIRGEDELGVWVDTYYPILNTPVHASVTLLSDPPFKAKLREDIVEGDPDSQLRDEVPVFHGLSASGDVKAKYVYAGYGRKKDFDLLQSKGVDFNGKIVLVKYGGSFRGLKVKAAQEAGAAGVIVFTDPGDDGEITEENGYEAYPEGPARQPSSVQRGSVQFLSKYPGDPSTPGEPAYKNATRIESGSQPSIPSLPLSYEDVIPLLKALEGKGIKASELGPYFTGGLEYYGVEYYIGPSDVDLHLVNEMNDRVLPIWNTMAVIPGHISDEVIILGNHRDAWVLGASDPSSGTASQYEVVRGLGALLRKGWKPLRTIVLTSWDAEEYGLVGSVEWAEDFGDWLVENAVAYLNLDGSASGTNFHASASPSIALLLKEAAEEINSSSDPSRSVFSTRDNAGNWDEYIFGEFGEGEFDALTVDAGSGIGALGSGSDFTPFLQRYGIASSDLGYKGGPKDPVYHYHSIYDSHTWQAKYGDIGFHRHTDAAKVIGLLTLRLADTLILPLNTTQYARDLAYYLEKVEDIANSSSFADSLDFETLSQSIKAVQESSIKLDVERKELTAKLRKLLPKPHFEKPSFLTRLTSGGCHQNEKSPELGNSNSDSIAFPKIPIPKLPKLEKLKEIKRVLKEIRKVNKKLQHFEYGFISEKGLKDREWYKHKVTAPGLWLGYGATTFPSINEAITIDHSLSLAQEEIEDVAQLLNGVAQKLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I362</accession>
    <name>A0A1B9I362_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Cation-transporting ATPase 13A1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I206_04513</name>
        <name evidence="17" type="ORF">I206_103914</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC69970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011201.1">
        <property type="nucleotide sequence ID" value="XM_019156243.1"/>
    </dbReference>
    <dbReference type="STRING" id="1296096.A0A1B9I362"/>
    <dbReference type="GeneID" id="30172882"/>
    <dbReference type="KEGG" id="kpin:30172882"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07543">
        <property type="entry name" value="P-type_ATPase_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000056">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000058">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000071">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057255">
        <property type="entry name" value="2TM_P5A-ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047820">
        <property type="entry name" value="P5A-type_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF7">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE HELIX TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23143">
        <property type="entry name" value="2TM_P5A-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1061"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1101"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1143"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="domain" description="P5A-ATPase transmembrane helical hairpin" evidence="15">
        <location>
            <begin position="75"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="14">
        <location>
            <begin position="319"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="1252"/>
            <end position="1279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF23143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCF49982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="WWC69970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1285" mass="143336" checksum="3751F74126474886" modified="2016-11-02" version="1">MIQRPRPTLPTTPSVNGLYPISILSTKTLSVVLQRSCSYINQEQGGSIRCKFKSTSKPSIVSQEIDSISLHNSIPVASRIYGLPFLSLYPLLYYAYYHKYDEWVVSEEWTFIYCVLLFAGHALSFLITAWSSGFNAKVSYTTANSLQEASKIRVIPSKGRGKGEIVPLDSKLAPGATEPTYSFIYQRDTYVLDSTTNSFTPIPYPCDSSPPLSTFQSSKGILTHPPTSAKNKQVPNLEVLKSTYGPNECHIPIPRFTELFAEHAVAPFFVFQIFCVALWCLDEYWYYSLFTAFMLVVFECTVVFQRVRTLTEFRTMSITPYPVQTLRDGKWVEVISSELVPGDLVSVLRTKPDSGIPCDLLLLRGTCIVNEAMLSGESTPLLKESVELREGSDKLDMNGADRNSVLFSGTKALQVEKAGEGGVTTPDGGCLAVVLRTGFGTTQGQLVRTMIFSTERVSANTFEAFLFIGFLLIFAIAASSYVWVNGLKRGMAKGKLLLDCVLIITSVVPPELPMELSLAVNASLVALQKYAIFCTEPFRIPFAGRVDVCCFDKTGTITGENLVVEGIAGVNSDDPKKLVPVTESSKNTTLTLAAAHALVLLEDGTIVGDPMEKTTLSALDWKLTKGDNISPNSKEAPHKHQINVRRRYQFSSALKRMSTISAVSDSQGRKWIAAVKGAPETLKAMYTTVPDYYEETYRWYTRRGSRVLALGIKEMNVRPEQINTIQRDEVESKLTFAGFLVFHCPLKPDAVETLKMLNDSSHRCIMITGDNPLTAVHVARDVEIVDRETMILDLKEGTTTDELVWKNVDETIVIPVKATEPFDQKLFDQYDICITGAALKQYEDLPSWKELCKHTWVYARVSPSQKEFILSTLRDLGYITLMAGDGTNDVGALKKAHIGVALLDGSPEDLKAIAEHHKMERMKKVYEQQVKISARFNQPPPPPPPALRDAYPELVKTQQEVADKHKGARKQNPMEKFDMATITAKLSELDEDTEVPQIKLGDASCAAPFTSKLSNVSAITNIIRQGRCTLVATIQMYKILALNCLITAYSLSVQYLDGIKFGDYQVTITGMLMSVCFLCISRAKPVEKLSKERPLGNIFNFYVLLSVLLQFAVHIVALVYITGLSKSLEDRGEVDLEKKFEPTLLNTAIYLLGLSQQVSTFVLNFQGRPFREGIRENPPLYWGLLGVSAVAYSGATDFFPELNRWLQLVEMTSSFKFKLTTSMVLDFVGCWAIEKSCKALFASLEPAELVTRGRERREKRRIEEERLRVEEEKTKLLTEVEKKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I3I2</accession>
    <name>A0A1B9I3I2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_03404</name>
        <name evidence="3" type="ORF">I206_105693</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011306.1">
        <property type="nucleotide sequence ID" value="XM_019155152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I3I2"/>
    <dbReference type="GeneID" id="30171773"/>
    <dbReference type="KEGG" id="kpin:30171773"/>
    <dbReference type="OrthoDB" id="2560567at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="537"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="565"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="589"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="613"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF50087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC71735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="677" mass="78155" checksum="7506900ABBA5013D" modified="2016-11-02" version="1">MGSDFVDKHYYINEKTGSTPFQRTWKKTSPIEKLLYIIYLIPLIALLIILGLIMILPFLFIRRTRPLLPKSEEIDPIYKKKKRGPGLHRRIWEMFEIFLNLYYMTLKQGLQVGGCLSSIILIYMQIRMIIHDLNNPIIIDYSQQAQISNSDPADRLRTDHDCAYGVGTGIANWANGKEPLAWYGMYHAFIIILCICLFGDELLNVRFGCFAPQWNRAGVGYTTMFLAVATLSTSPNWDFPETVQFRYIILILIFLLGLYNVLRTIVSMNGCTKSEIRFEDGRVGRKPLRFWTKGQWKSEWFRLNFLPPPGKGSYFWTENLQNYIGDWNFPLRIRSRKSLEKQIELQQNEIENKFDDGRIQKVYQKSEKELIWQRGRISRVVIHGGPRKMPPNLKAEIDAMKRIHVGQLPDYDGLLSDEEIEKIEEKVLAELEKDKGYFGIANWVPSVRVYAWLWFDVRRIFCIICGIGLLSIRAAICSFDLSAGAWYAYLDEYTKAQDNWKINGGPDDNTCQYYKGTSVPIFVLPGGKAVTGVAAMYIWVSLWNMFLVGMCLGVIGVAISNNMWWGMHLGLLGPIPVPITLIGPRMTSMSMGLTLGFVAIATLQQGFFFHNDFGIIATKIFCYAGVVGMILSLFPNEPLRPDFTRSPFWPWTSRYAFRRMDRKKWKYGWANNNDMYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I3N0</accession>
    <name>A0A1B9I3N0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_03452</name>
        <name evidence="2" type="ORF">I206_105648</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
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                <person name="Mohammad A.W."/>
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                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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                <person name="Heitman J."/>
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                <person name="Young S.K."/>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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                <person name="Heitman J."/>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
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                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
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                <person name="Imamovic A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="David-Palma M."/>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000931">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="114"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="144"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="202"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="341"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="672"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="752"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="804"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="341"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="392"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="680"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="755"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="804"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="818"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="853"/>
            <end position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCF50496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WWC71317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="873" mass="95283" checksum="E73C4D3A89650D65" modified="2016-11-02" version="1">MSIMFMTPISNDRGNPNRTPSPSDFLDLSPIPPRRPLPAFLPDPPASEIRPSPPCTTASPTRDDESISSSDTDTEMENSSPISLSTENLILSIEQLVNDHNLVGAGHDIHARPHVCDYPSCNKAFARKSDLARHYRIHTNDRPFTCTYRNCGKSFIQRSALTVHYRVHTGERPHHCETCNKAFADSSSLARHRRIHTGLRPYTCKIPGCGKPFARRNTLLKHWKRTHPGLPPPSTNSHKHNIHTPVVNTRLTSGSYPSSGSSVEQYPATPSSASAPHGYATLHPPEGTAYTFNGGFAGSIFGGTSGQPSYAVTGHPNAYRQPQHFYHPQQAPDHIALTPISSTNSHFGESVHQGDTNHTPSRPATGTYESEVKQQQGHGGPHSAHPGLSPSPGFNQQGFTYTQYHSPISGYPQSTDYPFSRFASEGGSVIFGDTKPNVNIAPRSISNPVDGPKYQPYNMASGPFGHVGGGFHPSQLAIPPNYQSHLMPSYHSANMGLHPKMTHEIKSELPQSSDESSSVEDDEPLVALHEAPPSFALHPPNGPAMSMPFSAVNSNNFGQFPGNHSQNYMPQQSSGGRLHSAPPTMQRFNSLPSEPTANTWGTSTVPYQSHSTGDAKSDDQEWEDIADEMLSREASVTDNTQVTSIEIEQKPLASIQEGNQWGEAISYPVPPLDNRKNPFSSSASSSSTSSTLVGSMHTAPAVNHLPPIYTHGNHHMALTPINPNGFYPTPITPANWAHDAIKPHAIFQSPAIHSQHSERDKENETTQEITLTTPPKWMEQQRKDGRTVSAVGLGIANVHFEDRESDITTSKEDKEWNEGEDERLSDDDTIEDKSDEEFVLGRRPKGKTGVGRGRGRGRGAARGLGGRRGRKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I4Z3</accession>
    <name>A0A1B9I4Z3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Adrenodoxin-type ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_03911</name>
        <name evidence="9" type="ORF">I206_105180</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the adrenodoxin/putidaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011805.1">
        <property type="nucleotide sequence ID" value="XM_019155651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I4Z3"/>
    <dbReference type="STRING" id="1296096.A0A1B9I4Z3"/>
    <dbReference type="GeneID" id="30172280"/>
    <dbReference type="KEGG" id="kpin:30172280"/>
    <dbReference type="OrthoDB" id="268593at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140647">
        <property type="term" value="P:P450-containing electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001055">
        <property type="entry name" value="Adrenodoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018298">
        <property type="entry name" value="Adrenodoxin_Fe-S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426:SF65">
        <property type="entry name" value="FERREDOXIN-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426">
        <property type="entry name" value="FERREDOXIN/ADRENODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00355">
        <property type="entry name" value="ADRENODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00814">
        <property type="entry name" value="ADX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="7">
        <location>
            <begin position="69"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF50586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC71227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="187" mass="20501" checksum="EDF1DE4B07075F7C" modified="2016-11-02" version="1">MSRSTMNFLRPLKNSRQIHSKISPSLASSSSSKNPIRIIKPILGSSIKRNLHTTTPRLHGEITRPEPGTGIKLTFKDSKGNEIKTIEGNEGDDLLSLAHEYDVDLEGACEGSVACSTCHVVIDPKHYDMLPEPDDEENDMLDLAFGLEDTSRLGCQVKLTKELDGLTATLPSATRNMYVDGAKARTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I512</accession>
    <name>A0A1B9I512_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_03943</name>
        <name evidence="10" type="ORF">I206_105147</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011837.1">
        <property type="nucleotide sequence ID" value="XM_019155683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I512"/>
    <dbReference type="STRING" id="1296096.A0A1B9I512"/>
    <dbReference type="GeneID" id="30172312"/>
    <dbReference type="KEGG" id="kpin:30172312"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF23">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="75"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCF50618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC71194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="181" mass="19984" checksum="302DCB83CCFDE831" modified="2016-11-02" version="1">MTAYKVDTHDPIGDTKSFSHQIETADDDHTATAEKHDEDVDRHLAVRCPESLRHLSPEETAVMDRRITHKLDILLMPVLMALYILNYLDRQNISSAKIAGITKDLHMTTTQYNTAVAVLFAGYVSLQIPSNMLISKISYPGIYICFMCAIWGTISACTGAVQSFAGLAVCRTILGFAEAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I520</accession>
    <name>A0A1B9I520_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">60S acidic ribosomal protein P0</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_03925</name>
        <name evidence="9" type="ORF">I206_105165</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. uL10 forms part of the P stalk that participates in recruiting G proteins to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011819.1">
        <property type="nucleotide sequence ID" value="XM_019155665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I520"/>
    <dbReference type="STRING" id="1296096.A0A1B9I520"/>
    <dbReference type="GeneID" id="30172294"/>
    <dbReference type="KEGG" id="kpin:30172294"/>
    <dbReference type="OrthoDB" id="10259902at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05795">
        <property type="entry name" value="Ribosomal_P0_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1730:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050323">
        <property type="entry name" value="Ribosomal_protein_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030670">
        <property type="entry name" value="uL10_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL10"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
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    </dbReference>
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            <begin position="109"/>
            <end position="178"/>
        </location>
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        <location>
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        </location>
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    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF50600.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC71212.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
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    </evidence>
    <sequence length="312" mass="33483" checksum="846275E7ACF8B3D3" modified="2016-11-02" version="1">MGATRANKEIYFEKLKALIEQYPSIFVVNIDNVSSQQLHLIRQSLRGKAVVLMGKNTMVRRAIRGLLAEFPQFEKLMPYIKGNIGFVFTSEDLKEIREIILANKVAAPARAGAIAPNDVYVPAGNTGMEPGKTSFFQALGIPTKIARGTIEIVNDVQVVAAGTKVGSSETALLNMLNISPFTYGLTVVQVYDNGAVFASSVLDIEEKTLIDGFVSGIKTIAAISLATNYPTIASVTHSLVNSYKNILNVSLATDYEFEGSAKIKEYLANPEAFAAAAPAAATESASAEAAPEAAKEEEKEESDDDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I586</accession>
    <name>A0A1B9I586_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_02695</name>
        <name evidence="9" type="ORF">I206_102348</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF50641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC68421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011860.1">
        <property type="nucleotide sequence ID" value="XM_019154457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I586"/>
    <dbReference type="STRING" id="1296096.A0A1B9I586"/>
    <dbReference type="GeneID" id="30171064"/>
    <dbReference type="KEGG" id="kpin:30171064"/>
    <dbReference type="OrthoDB" id="21467at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12307">
        <property type="entry name" value="RRM_NIFK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46754">
        <property type="entry name" value="MKI67 FHA DOMAIN-INTERACTING NUCLEOLAR PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="499"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="345"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="600"/>
            <end position="627"/>
        </location>
    </feature>
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        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
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            <begin position="388"/>
            <end position="400"/>
        </location>
    </feature>
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            <end position="424"/>
        </location>
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            <end position="469"/>
        </location>
    </feature>
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        <location>
            <begin position="600"/>
            <end position="625"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="OCF50641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC68421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="690" mass="74100" checksum="ABD4CDE6099462AF" modified="2016-11-02" version="1">MAKRAAPSSSTAPSSKKAKPASKGTPKGKKTSNETTDSPLDKAKQVASDIINTVSEVVDNAGDLILDDGNTPAPVSKVIEENVDVLALKKKGKAAKAKAVEVAQDAEEKLEQAVEKKTGVDVKKTKAKAGKVVKDAQDQVESAVEATKPLKGKAAKAGKVAQDTAEAAVESVDKVVKDPKNRKKAEDFMHSAEETVKAVAGKVGEVLSNVVDQFGEASGLSADLGTDVEKGKKVAAKKGKQVVEAAEEKVEGGKKVAAKKGKQIKEVAEDKVEEGKKIAGKKGKQAQEAAEDVVEEGKKIAGKKGQQAKKVAEETVEEGKKIAGQKGKQAKEVVEETVQEGKKLAGKKGKQVTEAAEEVKETTKRKAKNAVDAAEPTTKKVKAAAEPIIEKGKKAIKDAEPAVTKGKKAAASAAGKATKAAADAMDIDEDDNEEYIHGFSSSDGEGDSDDESDDDDEDRAVAEAGKKVDMSTLPMVAKDDKSVQAKLKKASKKKDDPKGTLYLGRVPHGFYEEQMKEYFSQFGDVTRLRLARNRKTGASKHYAYIEFSSASVAEIVSETMNNYLLMGHLLKCHVIPEDKVHPQLWVGANKKFRKIPTARVEKQKHEKERNDEEKGKADKKLLKKEGARKRKIKESGIEYDYPGHVSFNSNSTSSYSILAFIIFSFASLNSNFPLPHLKHHPKEVMLGANG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I5Y6</accession>
    <name>A0A1B9I5Y6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">Polyadenylation factor subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_03002</name>
        <name evidence="12" type="ORF">I206_102649</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
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    </reference>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="12">CBS 10737</strain>
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        <text evidence="6">Required for 3'-end cleavage and polyadenylation of pre-mRNAs. Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle.</text>
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            <location evidence="1 9">Nucleus</location>
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<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I6A3</accession>
    <name>A0A1B9I6A3_9TREE</name>
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        <submittedName>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
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    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
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            <orientation evidence="1">Cytoplasmic side</orientation>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Ras family GTPase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="Small_GTP-bd"/>
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        <property type="entry name" value="Small_GTPase"/>
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        <property type="entry name" value="Small_GTPase_Ras-type"/>
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    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
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    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
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        <source>
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    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC68817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="223" mass="24928" checksum="B53119C74915C8A3" modified="2016-11-02" version="1">MPHPSQGKTGHREQKLVVVGGGGVGKSALTIRFVTSQFYDQGYNPTIEDSYKRQFVVDDEAVTLEVLDTAGQEEFAAMADQWYTFGAGFLLVYSITDRPTFESLPNFHREILRTKDKDYVPCVIVSNKCDLSKLRTVGQLEGREMARNLSAPFIECSAADGVNVEVAFRELVKLVRKDQRREMLISQSFGMGENVLEDSQITNKTNNEKRNQVGIGSSCCLIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I6S7</accession>
    <name>A0A1B9I6S7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphatidylglycerol/phosphatidylinositol transfer protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_03286</name>
        <name evidence="4" type="ORF">I206_102935</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF51220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012439.1">
        <property type="nucleotide sequence ID" value="XM_019155036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I6S7"/>
    <dbReference type="GeneID" id="30171655"/>
    <dbReference type="KEGG" id="kpin:30171655"/>
    <dbReference type="OrthoDB" id="10448065at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628432" description="Phosphatidylglycerol/phosphatidylinositol transfer protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF51220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC68999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="20396" checksum="49D5ABF120D2D316" modified="2016-11-02" version="1">MRCQSISLLAFFLVSSVSTATPLHLDKREDSVINIKTALNTRLVQENDPSKIAVNGQESIFDFTRKSPSGTQESSPTITQSFYWDLFVKDDDYGMETQKSRLTCHVEVPVTFRGTAKYELHTDIGYPAVTLTSGILYDVKGIKISCPPEESKCTNDGSVDKDCPPDQRAPGFNADGNFRSSDWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I744</accession>
    <name>A0A1B9I744_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_02066</name>
        <name evidence="9" type="ORF">I206_104534</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012571.1">
        <property type="nucleotide sequence ID" value="XM_019153831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I744"/>
    <dbReference type="STRING" id="1296096.A0A1B9I744"/>
    <dbReference type="GeneID" id="30170435"/>
    <dbReference type="KEGG" id="kpin:30170435"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051698">
        <property type="term" value="F:saccharopine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF26">
        <property type="entry name" value="L-SACCHAROPINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="7">
        <location>
            <begin position="2"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="402"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="402"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="422"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF51352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC70583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="447" mass="49869" checksum="499CB3C2805FB5AE" modified="2016-11-02" version="1">MITKESKILVVGGAGTMGSSTALHLARRGYKDIRILDMFQPPSANSAGNDMNKLISTQYIDGIWGRLALETWDAWKSDELFTPFLHPVGRLDLAKKDKRRVASLKRQYDLNVSAGKGDNVEWLHNKEDILKKGAYLEDGEIEGWQGMWIRDAGWVAARDALTAVGAELRRLGVKSAFGTSGTFKSLLLGTDGTTVLGVKAVDGKEWPADLVIMATGAWSPTLIDLEDQCISKCWQFGHIRLSAEEVDKLKGTPTLYNSELGFFMEPSPEGIMKFVNEFEGYTRMATCRPFGAKTDITMSVPRSHALNPTDTIPEEGERAIKDVINTCFPQFSNKLLFDKAICWCTDSYDGNWLLCDDPRYNGLILATGDCGHTFKMLPIVGKYVADLIEGRLSREDRDRWRWRPEGKKAAETGREGPQPEDLNDKKGWRHDDPAVSELASRTRAARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I7I7</accession>
    <name>A0A1B9I7I7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription elongation factor Eaf N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_02150</name>
        <name evidence="11" type="ORF">I206_104616</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012655.1">
        <property type="nucleotide sequence ID" value="XM_019153915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I7I7"/>
    <dbReference type="STRING" id="1296096.A0A1B9I7I7"/>
    <dbReference type="GeneID" id="30170519"/>
    <dbReference type="KEGG" id="kpin:30170519"/>
    <dbReference type="OrthoDB" id="125903at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032783">
        <property type="term" value="C:super elongation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003711">
        <property type="term" value="F:transcription elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027093">
        <property type="entry name" value="EAF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019194">
        <property type="entry name" value="Tscrpt_elong_fac_Eaf_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15970">
        <property type="entry name" value="ELL-ASSOCIATED FACTOR EAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15970:SF2">
        <property type="entry name" value="ELL-ASSOCIATED FACTOR EAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09816">
        <property type="entry name" value="EAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription elongation factor Eaf N-terminal" evidence="9">
        <location>
            <begin position="10"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="115"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF51436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC70665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="326" mass="35509" checksum="8AF86631FB6AC0E2" modified="2016-11-02" version="1">MTSEISDGTYPIQFAPSITSQWGAKKRRRDEDDLIAFRYNFKPASITPNTPGSYNVSSGIGGSGQLVFDTNTGIQQVFDVREENSKARECVLIFNEETKSFTLHALPSTLHLTLNRSSRPKAPSVASISSSTSSRSIPLSKAQQNSKAEIVPDDEELGGEIEETPKVKRSRPSEIRQMKSGKSLPRKQPLATAPIPSFSTSNTTTTTKKATKAKTKGKTTTKKGSSVKGKKKLETIEPETPTKFKSSEFIEDSDEEIANSEANNPTEDQEFDEFANLLGQSLAQGDEDDSEEEEDEDDEDDEDLGGARLVVGGSSAALDDDGSEWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I7J6</accession>
    <name>A0A1B9I7J6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sm protein F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_02249</name>
        <name evidence="13" type="ORF">I206_104711</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012754.1">
        <property type="nucleotide sequence ID" value="XM_019154014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I7J6"/>
    <dbReference type="STRING" id="1296096.A0A1B9I7J6"/>
    <dbReference type="GeneID" id="30170618"/>
    <dbReference type="KEGG" id="kpin:30170618"/>
    <dbReference type="OrthoDB" id="409625at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01722">
        <property type="entry name" value="Sm_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000011">
        <property type="entry name" value="small nuclear ribonucleoprotein F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034100">
        <property type="entry name" value="Sm_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
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                <person name="Heitman J."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Zeng Q."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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                <person name="David-Palma M."/>
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                <person name="Mohammad A.W."/>
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                <person name="Yurkov A.M."/>
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    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="David-Palma M."/>
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                <person name="Yurkov A.M."/>
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                <person name="Cuomo C.A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="11">CBS 10737</strain>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
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                <person name="Young S.K."/>
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                <person name="Gujja S."/>
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                <person name="Imamovic A."/>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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                <person name="Gujja S."/>
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                <person name="Imamovic A."/>
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    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="Zeng Q."/>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="David-Palma M."/>
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                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 10737</strain>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
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                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
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                <person name="Imamovic A."/>
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                <person name="Wortman J."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
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    </evidence>
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    </evidence>
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        <source>
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</entry>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Abouelleil A."/>
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                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="kpin:30170999"/>
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    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.510">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF83">
        <property type="entry name" value="TIP ELONGATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="2">
        <location>
            <begin position="187"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="968"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="992"/>
            <end position="1002"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF51914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC71137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1067" mass="114497" checksum="E35ABF7B205207C2" modified="2016-11-02" version="1">MSSRLPTLSTPGRTSSPSTGIPTPTGRRPRSSLGPGHLPTSSTSDEIMDKALQEVLRVRPPSSLRNGDDPSSPSLLAASSGLAAPRTPGVRPKTPAGLGLGIGGPVTPSASRSVSRTGRQSLSASTANPFTPRRTSMASSTTSTTPFARRPESRASNAHDTSKWTPVVGEKVRINSMGYEGALRFLGPTQFKEGVWAGVELEGGFAGKGKNDGTVDGVAYFSCPPLCGIFVVAAKLSPPTAGPSRPASVASSHRSLASSSASYSLHGRATPSGRATPSFDRSTTTPGRTTRAVSSSVRRPPPLDDEEPLPTRTALGTSTIANADVGGKITAGSRASRYLGMTAKQLDSARAGTLNASVKGLGASTTTTPKPSRISMGLGGVTPARSGRQSIGGSLVTPRPTRGPRASNMHEMPPPPSPGNINRVIAARQAEALEEEIRELKRRNAELEEEIKHASENSANTSNLEELQVQANQAREEADSLRSQLADATDASRLAEELQIAHTASQEELAGKEKALNDLRKEMKLLVERNEAELSAGMESKKEEVHRMSERAEAAELEAAEMKALVDELTNAGQQMISLNETKQYELEERVRELEDRNRLLDDKLQKAREEQEKALLPPSPTTRQREATTAAEIDNETLTAQVKHQQNKISHLEEELEDLRVQAEQDVEAFKAKLGRSKDVEKASQEQIGGLRDEIKKINESLNGAKGRVRELEGALKENQSALEAARAEIEGLRGEASEAASMRSALQTANANEKALSAAQEDLEDLKAKLANAQKAESQLEQVQWKLSETEIRAEGAENKVVEIVERLNDLEGIKGDLEAKISSLESEIVTLKTTATASLENNLPQGRRSRLSTGSTDDADKKIRGFQHIIQELSAENSELKEQMDSLKEEIGLLKEEIKLLEESAADGQASGSGTSAADQKELVEAKTTIKELNREVAELESLIEAKIYREDELETRASNLEREIERLRSSNGGQVKGSDGPDSRISHSRTSSTATAHTDGISTDDRCELCEGPHDLDACPVFAGNMGVMDGGASKKTNTGRWCADCESNEHDTSDCPMAEDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I966</accession>
    <name>A0A1B9I966_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Probable threonine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I206_01350</name>
        <name evidence="17" type="ORF">I206_103647</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013285.1">
        <property type="nucleotide sequence ID" value="XM_019153124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I966"/>
    <dbReference type="STRING" id="1296096.A0A1B9I966"/>
    <dbReference type="GeneID" id="30169719"/>
    <dbReference type="KEGG" id="kpin:30169719"/>
    <dbReference type="OrthoDB" id="5423599at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01667">
        <property type="entry name" value="TGS_ThrRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00860">
        <property type="entry name" value="ThrRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000019">
        <property type="entry name" value="Threonine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000003">
        <property type="entry name" value="Threonine--tRNA ligase 2, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000006">
        <property type="entry name" value="Threonine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000005">
        <property type="entry name" value="Threonyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047246">
        <property type="entry name" value="ThrRS_anticodon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF46">
        <property type="entry name" value="THREONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGS" evidence="15">
        <location>
            <begin position="90"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="367"/>
            <end position="642"/>
        </location>
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        </source>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00072369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="752" mass="85383" checksum="EA1D8ED3E46414CF" modified="2016-11-02" version="1">MSAAAHPVQSSAEPAKPAEGLEPVTPGASATQVSKKQGEGKPNKKEKKEKKSGNGAGPLELNPPPEFFAERIQIYDKYKAEYEEFVAKQERVEITVTLPDGKKIEGKAWETTPLEIARGISPGLADKVIIAKVNNQELWDLTRPLEASCDLKLLDFDSPDNNYEARQVFWHSSAHVLGEACERRYDGCCLGYGPPLEEGGFFYDMSLAGGRTISQDDYKGIEDVCKITVKEKQPFERLELPKETLLEMFKYNKYKQHYINDKVPDGTRTTVYKCGPLIDLCLGPHVPHTGRIKSLAVTKNSSSYFLGDAKNDTFQRVYGMSFPDNDRMKEYKKYLEEAAKRDHRKIGKDQELFVFNDISPGSAFFLPHGMRIYNTLMNFIKAEYFKRGFSEVGSPNMFNSKLWETSGHWQNYSEDMFKLKVDEDTFAMKPMNCPGHCVIFDSRERSYKELPLRYAEFGVLHRNEASGALSGLTRVRRFVQDDAHIFCTPDQVESELYGAFEFLDAVYKPFGFTYKVGLSTRNPKKWMGDLALWDKAESTLREVLENKVPGKWHVNEEDAAFYGPKLDFQLTDALKRNWQCGTIQLDFNLPERFNLKYHSAEQASDKTPGAQFSRPVMIHRAILGSLERFIAIITESSGGKWPFWLSPRQVVVIPVAKAYADYAQQVAKRFQEAGLYAEVDLSDNTLNKKIRNGQTAQWNFIMVVGQDEMDAQAVNIRNRDDEVQGREETVKVDIAVEKLVALKETKAAISKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IA98</accession>
    <name>A0A1B9IA98_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_01630</name>
        <name evidence="3" type="ORF">I206_103365</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC69426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019153399.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="30169999"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="18"/>
            <end position="75"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="196"/>
        </location>
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        <location>
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        <location>
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            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF52341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC69426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="446" mass="48585" checksum="B85C9F6207914C49" modified="2016-11-02" version="1">MDTTLPSIVSRLFVEQNQRNIAKPHQSSTTSSGIMLPDPARSSSSRRADERIPLRSNLPPPSFVDVQETPSPPRKIISNCDKAKIEARPVTPLDFGNSSKDKTMPSNGKQIRTSIDQKLAVEPAIKGIPQGRQEDLAISVTNNSTSISVVSQNVATIPHRNGAFKDTRIKLSSLSGTMRSSFRDRSNDKDEKEKRSSSLKLHKGSVRSNQRGSKIISSSLKMGLQSDHRPVSPNHRSNHGATHSAYSDTSFNTANTEASLPLVPPSAPTESTECSTAEFSLLFTPTSQMEYDYPASITSSRSTQSRERVLGLISDPSPVSPAGMESFTNPAIEEVLPFAGGQPFAAWSSPVDNEGQISVHNHNVEVGRRGSMSPGRLAMLSPKDAPHTESSMSFEGWEEIPRPRSNLPGKKVWLGSRGDQSTGVYDVGAQEEDREVEVWAWVATKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IAF9</accession>
    <name>A0A1B9IAF9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cell cycle checkpoint protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_01905</name>
        <name evidence="8" type="ORF">I206_103091</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC69155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013831.1">
        <property type="nucleotide sequence ID" value="XM_019153670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IAF9"/>
    <dbReference type="STRING" id="1296096.A0A1B9IAF9"/>
    <dbReference type="GeneID" id="30170274"/>
    <dbReference type="KEGG" id="kpin:30170274"/>
    <dbReference type="OrthoDB" id="337581at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003021">
        <property type="entry name" value="Rad1_Rec1_Rad17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10870">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10870:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02144">
        <property type="entry name" value="Rad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01245">
        <property type="entry name" value="RAD1REC1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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            <fullName evidence="4">Phytanoyl-CoA dioxygenase</fullName>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1">CBS 10737</strain>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
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                <person name="Griggs A."/>
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                <person name="Hansen M."/>
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                <person name="Imamovic A."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="1">CBS 10737</strain>
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    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC69299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="34766" checksum="D4D3F21D94904D85" modified="2016-11-02" version="1">MPVAIDSPVIIPLSDEERSTGVIAENHLFDAIDALFNDGVVVLQNAIDVEVIDKLNEKMKEDTAKIMNGAVKGIHWNQGSDKGNVSQVPPILKEYMFPQVYANKLASSVLSGILGPQPELHYIRSNTLLGNTTTRQKVHKDVRGRHLSHPYAIAQNICLIDVTPENGSTELWLGTNNSSPWTDHEVMHLGFVAQDKLDERSKVRPPVYAPVKKGSLILRDLRLWHAGMPNHTDETRVMLAFVYFASWYQNTMKQKFPRSLRPTIEAMEKESKTKIVVDYVDDEEVKDYLSVEFQTLFTSPHHPNQEVA</sequence>
</entry>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
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    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="Dromer F."/>
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                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="8">CBS 10737</strain>
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    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="MFS_trans_sf"/>
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    <dbReference type="PANTHER" id="PTHR43791:SF32">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF52703.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC69063.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="511" mass="56869" checksum="37B923BC8C2F3C5A" modified="2016-11-02" version="1">MTSVLLDKQKASVTLPSSDEKSLDGNDFPALDLGADVIAEPGFTWTDAEERSVVRKIDFCVLPLLFLGFYVFQLERGNISNALTDGFLKSVGITQDQFNTGQSLLYLGIILLEIPSNYMLQRVGPRVWISFQVLAFGLVGALQAFQKGYGGYLATRIMLGVTECGYIPGALFIISTFYKRSELATRNSIFFIGNGLASATSGLLAYAILPMGTRFPQHKGWQWLMIVEGCMSIFVAVLLLLFLPASPLKPRPLFLPIRVWTPRQEKILAARMVRDDAKNNASSYQITFRDVRDTLANWRIWPHVLIAICLISQTGALGTYGPTLIKGFNFDTLTANALSSVSGWIGLVTTASFGFLSDRTRIRGPVVITGLTLVWAFWVAFQQKSLSTDRWLKYGLQIMVQGFSIPSHPINATWLSLNCRSPQERSIAMALFIMAANSGALVGSQLLRGDDAPLYRRGFKVCLCLVSLGLFVAILQHLQYRLSNRRINQLKENRVESLEDAEQTIEWNYTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IB85</accession>
    <name>A0A1B9IB85_9TREE</name>
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        <submittedName>
            <fullName evidence="4">Kelch repeat-containing protein</fullName>
        </submittedName>
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        <name evidence="5" type="ORF">I206_101094</name>
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        <name type="scientific">Kwoniella pini CBS 10737</name>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">CBS 10737</strain>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Murphy C."/>
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                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">CBS 10737</strain>
        </source>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF52948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC67171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="AlphaFoldDB" id="A0A1B9IBB1"/>
    <dbReference type="STRING" id="1296096.A0A1B9IBB1"/>
    <dbReference type="GeneID" id="30168618"/>
    <dbReference type="KEGG" id="kpin:30168618"/>
    <dbReference type="OrthoDB" id="25503at2759"/>
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        <property type="entry name" value="B30.2/SPRY_sf"/>
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        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="511"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF52948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC67171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1032" mass="113736" checksum="ADD116A3F3FB308B" modified="2016-11-02" version="1">MPPHRGGRNSPPVDPFPPLRRAGSSSSSNPSYASIAARSSHPQRYSSHEAGPAQRSWGTEDVDRQDNLDELNIHSHAPYAEPIDINPSPPWRSRTRRRSDHTSTEVNEAAHSLPEREGQSSRNRITATPSGSTQSRTITIANGARNPPSDSGEGISTPPQLPARPSNHSPPSPSPTHRTREQPSPSATRLAPMFTLEELLRTNPDRTEETTTNTNNTTSSSQPRRRADAATIRAHLQERRNERERASEPLPWGMRMERALPTGAGSGNRETTGSSSLDAVFSLFDDSNEPIVIPFPADNGGPSSRTITRMSGVPLDGSGNNNNPSQDASQAITSFLRRRRRNPAPVRPVTTVWDPAEILPADYLSGPILPSTNELDLEDEEDVDSEEERWASRLRIHNFSDVDLGSIVPGNQALHRGGNNRRRMSFLERIGAPSDLRFPEEFEERMDFPPPTRGVNEATGCEPTNRNLAENITPLVVRSGGVIRPRDASKTSSPVRKKQRPNPRYDDTPASPSRPAYLDISTLSKNVALPSSFIPPLRRSHLAVSTYKSGNTIRPLITFVGCNPKRIDEDATSLHTTTPIPIECGVHYYEVEVIDRGEEGFMSVGWMKKGTNLRRLVGWDKGSWGWHGDDGRSFEGQGRGERFSETWTTGDIVGCGIDFTTGQAFFTKNGKMMGHRFSNLSKGLNPAIGLRSVGESLSVNFDGPFKFDIASYVESTKNGIWSLIKNTDVESVPRLVDQIDPSTSKSTPLTAEDADLDSSTSTLKRANHKMALAKALEKELKEYEVDDSVQSTPDTSSLVDPIDKTTSALVLDYLQHNGHSSVLSTLRNAMVKRGRLPDSSRVIDVNDDHESTKKTPSELALSHFTTKQEALNWVHTTISGSFENLLPARLIQDLSLSSLPSSALFTMELYDFLHLLHLSALPTSSDDDFQNVLEKGKSIRSELVNWPLKEKTLAEKAFGLLGQPDELNDPFWAAKRTEWADGLVRILREANGLNQSSQLEHAIRQSSAVMKTLSAKNGKSGAAFIDVKRIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IBC7</accession>
    <name>A0A1B9IBC7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Atypical/ABC1/ABC1-C protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_00236</name>
        <name evidence="7" type="ORF">I206_101091</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF52935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014154.1">
        <property type="nucleotide sequence ID" value="XM_019152016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IBC7"/>
    <dbReference type="STRING" id="1296096.A0A1B9IBC7"/>
    <dbReference type="GeneID" id="30168605"/>
    <dbReference type="KEGG" id="kpin:30168605"/>
    <dbReference type="OrthoDB" id="1290869at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13971">
        <property type="entry name" value="ADCK2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044095">
        <property type="entry name" value="ADCK2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052402">
        <property type="entry name" value="ADCK_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018961">
        <property type="entry name" value="DnaJ_homolog_subfam-C_membr-28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45890:SF1">
        <property type="entry name" value="AARF DOMAIN CONTAINING KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45890">
        <property type="entry name" value="AARF DOMAIN CONTAINING KINASE 2 (PREDICTED)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09350">
        <property type="entry name" value="DJC28_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="624"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="798"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="domain" description="DnaJ homologue subfamily C member 28 conserved" evidence="5">
        <location>
            <begin position="295"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="4">
        <location>
            <begin position="708"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="521"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="529"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCF52935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC67184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1186" mass="132342" checksum="163A0EEC25D6B3CA" modified="2016-11-02" version="1">MLPVRRRAISAVNRRTLFHIQARSQQTLSSEIDASPPSSSSSSQSRLTGSAKLFAESLEEEEPISSTSKDHLIHNQGEIWTGEESTHDAVFRMLVDSKYKPLRNPEGIKHNASDDKIKSMIKSLDLNPRLGNPVVNTKSSLQPFTDADELANPHRTTIPPHLHRPWHSTYTGETKLQNNTPQIKYGTFIRSTKDGDSLTNLLELKLPPGASIDGKTRSKLINAKRSGKTIRRLDNAREGALDYKLGLNQDGQQILLEDGEEGEEGTFRGNRQVKGSSVLGAQKGGASGLRAWGGLVEDRIQRAKEAGFFKITNGKGKPIPRDPEASNPHLETGELLMNRIVKRQGALPPWIELQHSLDSTVNAFRTTLLTTYTTHLVRNVISSNALLPLPPLHSVPSSDEMWEAREFKFHQENIKQINDLVRRMNAQAPSPARRNLYTLEAELSKLRGDVLKNEVWNEVKRRAEDAAKFPANRPGPSGLPPFLFDNEGWNALKTATRRSFGTIAAPVSAVIGKGRVGGVVNSTREPIASDSDNGGSSGSSKGNSGGNKPLRVAVMSGVGLGAILYLYKRPVQNDSEAMSLGPVAEKQVMEEEDIVALSPTEKRMGPVLFIQLYILEPLATLFRFFHLAILFGPVILTTPMLLVGKPEKRRRTGKPIAEEEENWGAVWWYAFLVKQMERAGPSFIKLGQWAASRADLFPAELCDKMSKLHSNGKPHSLAHTKRILEKAFGMHFDEIFDEFDEEPIGCGAIAQVYKAKLKQAVFSGGSATSSHAEVEEKTRSVAIKVLHPRARKTIRRDIAIMSVFANIFNAFPGMEWLSLPEEVNVFGEMMNSQLDLRVEASNLDKFEANFEKRGRRVTFPKPFKIKSQHGDSKDVLIEEFEDALPLKYFLQNGGGDYDDKIANIGLDAFLEMLLLDNWTHGDLHPGNIMVRFYKPTTIDYLGPLLNRFSKHSQTPPSDTPPSDTISNQQLIHSLASIAHDHDQWHERLDQLSKEGYEPQLIFIDAGLVTSLDDTNRRNFLDLFQAIAEFDGYKAGKLMVERCRQPENVIDEETFALKIQHVVLSVKSKTFSLAKIKISDILNDVLNSVRKHHVKLEGDFINTVLSILLLEGIGRQLDPDMDLFKSALPILRQLGRQMGTKEAINAVPKGNLLAMIKLWVWVEARQVVGEASVLDQWIKYDRLFPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IBZ9</accession>
    <name>A0A1B9IBZ9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_00248</name>
        <name evidence="13" type="ORF">I206_101079</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF52947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014166.1">
        <property type="nucleotide sequence ID" value="XM_019152028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1296096.A0A1B9IBZ9"/>
    <dbReference type="GeneID" id="30168617"/>
    <dbReference type="KEGG" id="kpin:30168617"/>
    <dbReference type="OrthoDB" id="5421at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140674">
        <property type="term" value="F:ATP-dependent histone chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045815">
        <property type="term" value="P:transcription initiation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001218">
        <property type="entry name" value="AAA family ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000016">
        <property type="entry name" value="ATPase family AAA domain-containing protein 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000061">
        <property type="entry name" value="ATPase family, AAA domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045199">
        <property type="entry name" value="ATAD2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069:SF0">
        <property type="entry name" value="TAT-BINDING HOMOLOG 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="685"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="987"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="127"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="244"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="581"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1388"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="367"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="402"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="419"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="446"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1392"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1433"/>
            <end position="1452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCF52947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC67172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1594" mass="174933" checksum="A91EA20ACAEA0CBE" modified="2016-11-02" version="1">MSSYPNPNSASSVPYNTYPDQQNVRPPQQNHNPNYGYQAQPQQGASVHSLTGGGESPFPTQPNYHYYAQNPVINNEYIPAQPTYPGSYGVYPHPDQPVNNYIHPYSHRTYYPSPQAQFLHSPQQQIPYHRSPSQLSTNSGQSASPVVSNLPPQAEAAYPQPSLSPLAGGIDSSVVRNQSIHQQPLIPIHLAQQQKPANIPSITPTAQASSSKSPLKIRLKLSANTASQDPKMVGRHHHVAVVQEESYSGRPRRGASQRAQAQMVSYQEDEDDEDFEDAEGEEDDGVGNFVPDIPIEPIRPTRSTRTAKAPESYGNEDDFEDKLMPSSPHEVVETRRTSGRGKRIVIDPDEEDDEDFKPSVPPRNAFPSRTTRTSIGSVQGTIPIEAEVPAAGPSYSNGNSKTPKRATRQSSKVRHSSADAEEFEPTDDGSISDDHASSDALGNYDHDEEEEDDDDLISRSSHESLRKRKTRSSARNIHTRSMPTRRSTRSSRKKADEESDDEYGGGGKRNLRTRTSKPNYHIPTIDDLSKEISMAEAMAAASRPNGRPGGVGGLGNGVRFGASGSKKGLPWSVKGRDLAQAMGDPDTSDSDDFATPLKSAGAGAGASMTGAGPVQRTNAVGPSDVPNYGRINPKSNMADADPLGVDMNVTFDNVGGLDDHINQLKEMVALPLLYPELFQQFGITPPRGVLFHGPPGTGKTLLARALAASCSTGNTKIAFFMRKGADVLSKWVGEAERQLRMLFEEARACQPSIIFFDEIDGIAPVRSSKQDQIHASLVSTLLALMDGMDGRGQVIVIGATNRPDAVDPALRRPGRFDREFYFPLPNRAARKKIIQINTRKWDPQLSDEFLEKLAQLTKGYGGADVRALCTETALNAIQRRYPQIYKTADRLQLETKSIHVSAKDFMMSIKKIVPSSARSTSSAAVQLPSHLVPLLSAPLDRIRKAIDHVLPPRKQATALEEAEWEEEEGDSFEKHMMMQSLDKLRTFKPRILVHGESGMGQTYLGPAILHHLEGFHVQSFDLGTLMGDSTKSVEASVVQLIIEAKRHQPSIIFVPSLSAWSATITDTARATIKTLLDGIAPTDPILLLGVSDAPVDDLPFDVKGLFGFGPENRIGLELPTQFERSAYFSDLLAAIHRPPTEFPDGIPRKKRVFEVLPLAAPLPPREPTAAELLREDEKDQAARDMIFQSFVHLVRDFLKRHRKVVASVKDDAIAYSNYLAEQAALTANPSAPASAPVITIDEVEPEAAAIMPTTEGDVAMLIDPSIPPVVTVNGSLPSTNGADTVVSPDPPFEVVPSAPAEVWQAHPIDIDTLQFKLLKHKYYTPSDFLADIAKIEENAAKLGDPDRMARVQEMSSSARYHVQGFDQKWIPEFERYKERVLAKKAEKQKKKAQAEAEKDKGKEKQGESAPVDLQVNGDAGTIPVIGEASTLKRARDGEHDGGELSHETQGREKRIRDGEMEIDETQLNEPQQIANSVSSTLLNGSQPLLPAAISTSMSLVETTTIPSVPPPSTSIPTYPPFNVPQDILSGLVHDLNSISNTLNIDQLEQLRASLFDIIWRCRTEWDRTAMLENMRSRVVEWGREVEKWKEAGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IC92</accession>
    <name>A0A1B9IC92_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7704 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_00348</name>
        <name evidence="4" type="ORF">I206_100978</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53047.1"/>
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                <person name="Heitman J."/>
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                <person name="Young S.K."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="Zeng Q."/>
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                <person name="Mohammad A.W."/>
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                <person name="Litvintseva A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
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                <person name="David-Palma M."/>
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                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
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        </location>
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        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="657"/>
            <end position="666"/>
        </location>
    </feature>
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        <location>
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            <end position="677"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="730"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="765"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF53077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC67041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="784" mass="83978" checksum="8FA4962BDE500DDD" modified="2016-11-02" version="1">MPFLQSISSFFAGSSSTNGSSSRTANRRSVMDSTTDAFSLPTAQGIRYGNGTGYGDGGLTTDSAASSPGPSRRGSLLPPPKDAFAGSPNYFPPPSHTFHRLRNALANSFPELLETLNGPANPHLLAAFEAELGCALPRAVRESLLAVDGQDLEACANISGSGGLFLGLHFLPLEDIMREWAFWRQAEHDPMAGNNAAVLATMASVPPNWIKKLYACRGWIPLLSDRTGNYVGVDLDPGHSGSWGQVIVFGRDFDRKCVLWRGDGEGGWGKWLASFVEDLESGEGWEVEKNGGSNGSTSDEEEDIGYGSYNGGGSFGESGSGLRLAGEYRGWNVLEAWWDKSVRKWDSLGLGLDVEDIEKGLEEARALAGYSEPSQVGKGKGKGKAVEGLGIGMRVGESAAQVEIPVVGSPHIPPGPGTPVPHDSDVLLPPASPEQPPIPKIRHPAPSPVRIITPIAATVDHPLRVTTDSSGYLSPPSRSPPRSRRREPPPIASPIDLPTRADVQAMAAIAQAEKSGLRGGWVMNLDVSAGNAARRASKLSPGLAENEMVDIDLEGGRAERFGSPRMTDAEMERQREEEKLALAGVEHRRSPQLVQPSRTPSPLSRESSFDEPSPSPIGSASEKTPRALSRGNSEGLISIPPSVIAATQSIRPPPRAANNSELNIRTFTREDEQRDAPLFRGNSSRPGRKERESSVVSMTSQDELLDRTSGNRSPSPSFHSTNHAGGEFVNSPTGISMSRTNSETNNEERLASPLVSESGRRNGFRRVDEQDKGLEEEMEEISIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9ID25</accession>
    <name>A0A1B9ID25_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_00817</name>
        <name evidence="3" type="ORF">I206_100510</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014731.1">
        <property type="nucleotide sequence ID" value="XM_019152593.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="30169186"/>
    <dbReference type="KEGG" id="kpin:30169186"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF53512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC66607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="27682" checksum="D127CE2500B92D85" modified="2016-11-02" version="1">MCQPGKTDLSLPKTYDSSSIQSTKSSLSRNHITEYIQGQNSGKPRKTRSRRGFPCSTCRSRKKKCDRDPTVATSNLECIKQSSTERNTVPSDYVELVEQEGYHNHRFSRKEGDIDSGPDLHMNRSDGSFGSTFGEESPAFSPGSFDSFPAAQPGWYKYSTGDTVNGYDGSMGYHHSPSGSSGKASDLRQNAHYEKGVDMVRGISLEDVLGQIGSPDVNLSPISDFARGIGEGHEASERRNTAPGDQIRSPDGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9ID26</accession>
    <name>A0A1B9ID26_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="8">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I206_00669</name>
        <name evidence="16" type="ORF">I206_100656</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="8"/>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC66751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014586.1">
        <property type="nucleotide sequence ID" value="XM_019152448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9ID26"/>
    <dbReference type="STRING" id="1296096.A0A1B9ID26"/>
    <dbReference type="GeneID" id="30169038"/>
    <dbReference type="KEGG" id="kpin:30169038"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072666">
        <property type="term" value="P:establishment of protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08382">
        <property type="entry name" value="C2_Smurf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000017">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000077">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000156">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.90.1750.10:FF:000005">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024928">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
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    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF440">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NEDD-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001569">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 8 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="13">
        <location>
            <begin position="265"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="13">
        <location>
            <begin position="363"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="13">
        <location>
            <begin position="421"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="14">
        <location>
            <begin position="510"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="176"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="236"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="331"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="333"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="9 10">
        <location>
            <position position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR001569"/>
        </source>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
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        <source>
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        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCF53367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="WWC66751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="843" mass="93641" checksum="BDB1C77B9EC5E505" modified="2016-11-02" version="1">MVANSASANRNLSRSIRVTIVAADSLIKRDILRLPDPFAIVSVDSEQIHTTSVIKRTLNPYWNENFDITVKDSSIVAVQIFDQRKFKRKDQGFLGVINIKVTDVIDLELGGQEMLTKELKKGSDGQAVQGKLIVYLSTQTGGPAPAAAPAASTSNTMLNAPANGSALSLNTAAAVNTAGSRPGSTLRAANATPEPESPSPATAPENPTIAPPSAAVPQPISANAAAAALSGAPTINPTAQAASTGQTGNNTAPGNEFDSHSDQYGALPAGWERRIDHLGRQYYVDHNTRTTTWNRPSDNQLSNNASQATTTGEARARHNQRNLADDMLDVQQSNTGGASTPTNGGTGAAGAVAPNNVTTAGQGPLPAGWEQRFTPEGRPYFVDHNTRTTTWVDPRRQQLLRVLAPGQGSLTVQPQTVSQLGPLPSGWEMRLTSTARVYFVDHNTKTTTWDDPRLPSSLDQNVPQYKRDFRRKLIYFRSQPALRNNTGQCHIKVSRDNIFEGSYTEIMRQTPNDLKKRLMIKFEGEDGLDYGGLSREFFFLLSHEMFNPFYCLFEYSAHDNYTLQINPNSGVNPEHLNYFKFIGRVVGLGIFHRRFLDAYFIVSFYKMILKKKITLQDLESVDSGLHRGLTWMLENDITDVIEDTFSITEEHFGEVVTVDLKEGGRDIEVTEDNKKDYVDLVTEYRISRRVSEQFEAFMSGFNELIPQELINVFDERELELLIGGMSEIDVDDWMKHTDYRGYNPSDEVVEWFWKIVRGWPAERKSRLLQFTTGTSRIPVNGFKDLQGSDGPRRFTIEKAGEPTQLPKSHTCFNRIDLPAYKTYEALEQKLTIAVEETLGFGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IDX2</accession>
    <name>A0A1B9IDX2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I206_01092</name>
        <name evidence="14" type="ORF">I206_100233</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019015004.1">
        <property type="nucleotide sequence ID" value="XM_019152866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IDX2"/>
    <dbReference type="STRING" id="1296096.A0A1B9IDX2"/>
    <dbReference type="GeneID" id="30169461"/>
    <dbReference type="KEGG" id="kpin:30169461"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097435">
        <property type="term" value="P:supramolecular fiber organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000008">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000009">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IE11</accession>
    <name>A0A1B9IE11_9TREE</name>
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        <submittedName>
            <fullName evidence="2">Endoplasmic reticulum protein</fullName>
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    <gene>
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        <name evidence="3" type="ORF">I206_100281</name>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="WWC66380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        </location>
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    <evidence type="ECO:0000259" key="1">
        <source>
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            <dbReference type="EMBL" id="OCF53737.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC66380.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IEY9</accession>
    <name>A0A1B9IEY9_9TREE</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    <gene>
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        <name evidence="2" type="ORF">I206_100161</name>
    </gene>
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        <dbReference type="NCBI Taxonomy" id="1296096"/>
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    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Murphy C."/>
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                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019015079.1">
        <property type="nucleotide sequence ID" value="XM_019152941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IEY9"/>
    <dbReference type="GeneID" id="30169536"/>
    <dbReference type="KEGG" id="kpin:30169536"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCF53860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC66260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="154" mass="17903" checksum="2936620A43DC3122" modified="2016-11-02" version="1">MLTFQHGNSSLKRSMRPDTVIGIERNFDSTDEPTNATFSISGWTERYCNRMSLFKPNKQIKDDLEKFSVEWKKDIATWSDSEAIKNDIASARSQNRLPEWVDSRLISVASLARCMSKFVVYDKSEMKDLVEEDWQEFSRDPSFVDLTVQFDSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8KXT4</accession>
    <name>A0AAJ8KXT4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_100334</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058278.1">
        <property type="nucleotide sequence ID" value="XM_070202177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8KXT4"/>
    <dbReference type="GeneID" id="30169360"/>
    <dbReference type="KEGG" id="kpin:30169360"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF83">
        <property type="entry name" value="ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="92"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC66432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="668" mass="73020" checksum="CC65AA8C140A4586" modified="2024-07-24" version="1">MFRKAKTASIPLESDPSIRRSYLSPNELVTRPAGDEVTVVGDFFAYCARKYGDQIACYYRDIVDVVEETKVVPKSDGTGDEKKIWKYFTLSTPISVTYNQLNASVAALSSGLINIGFTDPSTPIASRPRVSIYADTSLNWQLMSQTFARLGHVLTTAYTTLGEEGLLTSLVEPEVELCYCGEAQLELIAKVVERAEKLRYVVYDGDENRLSQDTIQKIGKVLNGRGGRTLPLQEVKQSGIDSPVKDFGFKPTENDLFCIMYTSGSTGKPKGVLLSHKNIVSSIAGATLLWGKNFNRSDLLLAYLPLTHILEQFLEFEFYFIGVPIAYGTVKTLLNDNVRNCDGDFVAYKPTLLPGVPAIYEMIRKGMVKKIHDAGSLVGTIFNIAVLGKQSLPWPFSSAIDKLLFAKVKAATGGRLRLAISGGGPLSADTQRFLSTVLVELIQGYGLTETCGMATICGPNFSPIGSVGVIGPSCEIKLQDYPDAGYLSSNKPPQGEILLRGPNVFQGGDIGQWNIDGTLSLVDRVKNLVKLQNGEYLALEKVESVYKHCNSVMMLCIVAPPNADRPIALVYPHEGNLRNRLKANGIVDDGGPKQWASNLTIVSYLIGELRDEAKKGGLRGAELIGDVILTEEEWSPENGMLTPAMKLARNNITKKYQSQIDNSIGKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8KZC1</accession>
    <name>A0AAJ8KZC1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycosyltransferase 2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_101586</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058520.1">
        <property type="nucleotide sequence ID" value="XM_070202419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8KZC1"/>
    <dbReference type="GeneID" id="30174813"/>
    <dbReference type="KEGG" id="kpin:30174813"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057688">
        <property type="entry name" value="DUF7928"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408:SF2">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25550">
        <property type="entry name" value="DUF7928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="344"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="381"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="792"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="824"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="864"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="917"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="951"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7928" evidence="4">
        <location>
            <begin position="119"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="3">
        <location>
            <begin position="593"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC67674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="977" mass="110546" checksum="26F844D7BA49C9EB" modified="2024-07-24" version="1">MSFLRRMSSAASSFIPSIPNAQGVPASHVPRRPTETFSRTSKAFIEQDDIDEKASRASWELSDNESVSSKGSRSSKSGASFATSDSGDIDKKSFDESDNSSSDDSDDDSILDRGGRPRDRYDMMVRHLWNVAERQGWFRDAEFDGLVSIRVKKRVLRTYPQPKNTKKGARELGRRIKEWDAAVSTLNPEVAMKITSKVVQAIMARCAEDAIEITLDVNTRIQILDDLTQLAGARKHQFAAFVRADACLIVWADEVETLIPSAEALEQRMIAYVWSGRHHELQLLEPESESEDGIDEKGEGEEGWVDRDAEKEKELADADGAVDEEKVGGKEGDWEMRDRRPVMLYAPLVSGLAMILTFVFIGSGIRNLIKEVLLDGSMVRMALIATAPFGYLLAIFFSICVMGNLWQIFGPVAQCHQNSSYFSGKAPSRMTGRLPHITIQMPVYKEGLEGVIIPTVESLKKAITTYERQGGSVNIFIFDDGMQIWDEEEQEIRKAYYDRNNIGWTARPKHGKDGFIRKGRFKKASNMNFGNNLSLRVEELMDELRPSAEEQEDTEWLWTDEDEREIYDEALAKALEESEGIAWAAGNIRIGELILIIDSDTRVPEDCFLDAASEFAQSPNTAIIQHESAVMQVVGHFFENGITSFTTRINTAISFCAANGEVAPFVGHNAFLRWAAIQDASFIDADDGIRKCWSESHVSEDFDQALRCQMRGWSLRWAAYSNGGFQEGVSLTADDELNRWQKYAYGCSELLFHPLRHWFTKGPITPLYRSFVWAEGIPLHSKISVLAYISSYYAIACALLLSCLNWVLIGLFDDVLDLFYLSSWQVFLTCIVIFCGLSNVSSALFQYRLNTNSLGNALIQNFKWIIFFFFFFCGMSWHLSTALCAHLTGYNMQWASTVKEVELSHFFKEWPAMWKRFWDIWIVSWVMILGVAFMASPLVPAGYRITNFTCILPLMAQACCHFLYPIVLNPWLLLFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L035</accession>
    <name>A0AAJ8L035_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ras family, other</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_101998</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC68079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008350.2">
        <property type="nucleotide sequence ID" value="XM_019158604.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L035"/>
    <dbReference type="GeneID" id="30175278"/>
    <dbReference type="KEGG" id="kpin:30175278"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001990">
        <property type="entry name" value="Ras family, other"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC68079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="26733" checksum="CC56ADC889DBC3EB" modified="2024-07-24" version="1">MLFKITVLGDGGVGKTALTVQFTMSSFVETYDPTIEDCYRKQWVVDDQPCLLEVLDTAGQEEYTALRDQWIRDGEGFLIVYSITSRATFERVERIVERVIRVKDENSLNNNNNNSTYGIYQNHYNYSSSQSSTINPTRSLNKIPIVIVGNKKDQYHSREVSTEEGIQLSKSLNCHFFETSAKTNNNVENSFKSLVRQIKVSKRLPSQNLNNNQDYPHAVYGGIAKKKKQKCIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L0K0</accession>
    <name>A0AAJ8L0K0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_102259</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058636.1">
        <property type="nucleotide sequence ID" value="XM_070202535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L0K0"/>
    <dbReference type="GeneID" id="30175998"/>
    <dbReference type="KEGG" id="kpin:30175998"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF33">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="147"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="371"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC68334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="760" mass="83401" checksum="914190951DC49AD1" modified="2024-07-24" version="1">MYIDVVSEVGSGFSHIESRADESVIAIWDKKWFETLPGEPTTLFELFDMSVARHPNRALFLRRAIVPSNPAAPASLTNTSPAEPVYSRTLIPTSYGAFQTRRSNTGSALLALEREGRLKSSIGTNGVSPPEITHPGVPYYGNSNRHKAGSRRGWAVGVWSKNREEWQVVDFACQAYGLVGVSLYETLGPDVAQYITNHCPLPIIFASSNHLSSLLKIAPNCPSLKIIVSMDPLPYSERKLLSDWASSLNIELLVMDELEQYGSTDGVYTEPGPVKNVAGDLDLDRERIVTVSYTSGTTGDPKGVVLTNKNLTYAIRSNVLGSTDGLMTDDEWRYISYLPLSHMYVQMPGLGPRYERLTDYSLVQRFLHFVVIHGDGTIAFTTGDVTKLLEDAQIIQPIFMAGVPRVWNRIHAAVRTQMDAGGLKGALLKKAVEAKLANWRETGSVTHPLWDALVFRKIKALLGGKLVYMCSGAAPLAPDVHEMLKICFGCDVIQGYGLTESVGTCTKGIGRDVRAVGTIGFVQTCNDVKFVDQAEMGYTSNDKPNPRGEVCLKGYNITPGYLHNVKATTDSIDQDGWFHTGDIGEITPQGHLKIVDRVKNVVKLSQGEYVALEKLESFYALDPLFASLLVHADSTRSSLVAVAVLDPIQTSNFCSSALGKHVKPEDIRGLQEAVSDKKVRKLVLKRLAKISKQHKLNGFEMIKGIHLTLQPFPDEVMTPTLKIKRNVAAKTFKNEIETAYKEAEEKGDAEGAGADAKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L0M0</accession>
    <name>A0AAJ8L0M0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_100907</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="7">CBS 10737</strain>
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    </dbReference>
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        <location>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L165</accession>
    <name>A0AAJ8L165_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_101528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
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        <lineage>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
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                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
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        </location>
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            <end position="120"/>
        </location>
    </feature>
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        </source>
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        <source>
            <dbReference type="EMBL" id="WWC67618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="195" mass="21746" checksum="6CEAFAFD05C30A8B" modified="2024-07-24" version="1">MQFTSQVHGKQRFELNPLIREAKRAIFNEQRRLEKLKRKYDELISYNVPSSSSMDNPSASANTHKAPNRPNKSGAKTVNKPHPVDKAFDSPAESQGNSARDKKAGPPHRSMNSSLFSQTRAKTHARPDPSSNDGKTTKRTSEIHVDQLEKKSEDEDDDDNDGQIPTNGSLKKTETEKKVHFGNSDSADSKSSDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L5C1</accession>
    <name>A0AAJ8L5C1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Autophagy-related protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I206_103651</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:38663"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)</text>
            <dbReference type="Rhea" id="RHEA:38571"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:38895"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATG2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058910.1">
        <property type="nucleotide sequence ID" value="XM_070202809.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30169715"/>
    <dbReference type="KEGG" id="kpin:30169715"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026849">
        <property type="entry name" value="ATG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13329">
        <property type="entry name" value="ATG2_CAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="299"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="379"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="994"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1534"/>
            <end position="1574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1695"/>
            <end position="1727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="385"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="428"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1003"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1561"/>
            <end position="1574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1698"/>
            <end position="1709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1715"/>
            <end position="1724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WWC69708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="2024" mass="221394" checksum="E228DD7A8CE30608" modified="2024-07-24" version="1">MFSLPAFLTTFPFTLPSLPSVSLPANIQRRFLSYVLKRSLGRFVKGEALDAERIQAQLSEGWVEIEGLEVDTTEINSLIPTSIPLILESGTLSKVTARVPLSNLWSDPLCLTLDTLSLSFVLSQPSYVEKGKRAARNSPRELHRDLAESVTLAADHFLHEELDAYEEAELDRSIRQSLVLNATDPFNNDEVPGSFPFDGPTSPGLDGQPLPANVESTTILAGLVERILSRLEFKLKNVNIQIRFEDEDHGGIFEIRVAEIKYSDESQSQAPAVGSSNNRTIRSIRLSGVTLHLLPHLQATSVPTGSSGPRSMSTTSRSSSISSTSSSSTGGEYQDMIMSQAVVNLKQSTMSNLDSEASVYMSAISERPPVSIPHILEEAIEDNSSRSPTPTPKSSSKSPEDTMIVTFGSEDIVLRMTTTPPLAAFAEQPSSPQLHPPTTSKQFPSTSLPKIDVGISLGTVATVITPEHLAIILAALQYVSSTGSTQSDPTPAAPAATMTNQPQFNAHVRMKALFASVVYDMSASTDSQYSTNIASFWSKPSSTYIPYGHLRLRLDTLEASHSSKEYIKSHATHRTTRAGHPTLARLPRRASTSIRSGPTLSTSHIRLQDASLFEYLASDTGNDDATDVPPGGAFPVLLFDTNLPRQYDVGPGVSSSSFASIGPPNRPTTDAGGGFAVFPEFDSVDWRNSGLQRKAGGSEKQWKVKQKGKGILKGTQMPDIEQPPVLSLQKDLVTNSTAMVSLSPIHVFVDLSLVERLLPMLRSIAPAVRSAPEITERFEPFASRSLRRPSLPTRHSTTDSIIDDLDAQASSYSTIQATPPAKPVFDIQCPLLRVDIRCPAPVNRRGTWGDGGHLRSGIVTLDMHNFWAKVSSTDQRTGRKAEGTNVMWEKMILFFSRAPERKSSAFIVIGPLAPDPAEIDVSPLSPNISLRSSSSSTRGKTTIVTCRVPSIQAKIKQQTIEGLQFFADDMTHWLDGAFGDGSAPKPRDDLKMIGSRFFGAPGSTRGSSSASSSTDEDDEEELSSTILKLEISETDISLYVPLVDGGERVLALKASDTDVKVESNLAGRHETAFSLNVMDAEFADRTDTVNPTKILGRTTPYTLTTLQQPLVHLRFTSQSNVVAQTKETGISVDLSRLTFFVKSIDWVKDLARFAKTPEGVFEDVVPSEVTRIKVLIQDCSIHAAAPTLGGAVVLVLGVVEVSTDIRSDGEENEVKVSAGRLTVFAVDDLAAVAKMGTITGEVSETWKKAGYAQLAEIISVDLHYLRDLTATEQSLLEILQVQSSITACADSLASFGSLLGDIAKIVPAKPAPPRAGPRPSTLDRSINVFDSIDEQAFNLIPDIVSGSEADMIDDDLPTNLDYLDRASRLSSRQLTSDRITGETLRAWQTDEDEELGSETIKILYDEKFDMDENYWDNLPVLREGHDDNLQIGKIRVRVKDCDAKILLFEGYDWLKTRKAIEDEIRVVRKRLERIRQLLATGQKADESIDFDRATKSVLFNSVYIGLENGQSAGEMDNAALIAAIDEELDDFDDTEKESMNTSWQTLPSAPMAGHQPTSNNRKSKTKLRGRKLTRSKKPQIEISLSSLRAEYDFYETSSSSDLSSELEIKVKEMEILDHIKTSTWKKFLMGMKADSRGNVRETDADMLRIELKGIKFGSDQDEEMRLRAKILPLRLHVDQDALDFLKRFFSFKAPTPQSPASPGTVSATSIPRADTTSPTTSNSSVPMKSNDPFFQHVEIFPIELKLDYKPKRVDFAALREGKTIELMNFFHFDGAEMTLRHITLSGITGWERLGTTLQDLWTPDVKANQLADVISGVSPIRSIVNVGSGVADLILLPIEQYRKDGRLAKGVQRGTNSFVKSTAMEMMKLGAKLATGTQIILEKAENVLGGNNEKLIASVSNLQQFGEGNHLNSWDNKNGSSSEDEDDLVSRYANQPEGVKQGVQAAYKSLSKNVNAAAQTILAVPMEVYERSGDDGPLKAVVRAVPIAVLKPMIGTTEAVSKTLLGMRNSLDPSARRELGDKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L5S7</accession>
    <name>A0AAJ8L5S7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I206_105077</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC71124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059157.1">
        <property type="nucleotide sequence ID" value="XM_070203056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L5S7"/>
    <dbReference type="GeneID" id="30170986"/>
    <dbReference type="KEGG" id="kpin:30170986"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10951">
        <property type="entry name" value="CE4_ClCDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF2">
        <property type="entry name" value="CHITIN DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042593543" description="NodB homology domain-containing protein" evidence="13">
        <location>
            <begin position="20"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="14">
        <location>
            <begin position="39"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WWC71124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="250" mass="27677" checksum="A4A21962A07CBF32" modified="2024-07-24" version="1">MFSKSLAITLLTYLTAITASPVSTRQNGLQVINNCYQSGQVALTFDDGPYIYENDVVNSLNGGRGTFFLNGNNYVCIYDKVDEIRALSAQGHTLGSHTWSHPDLTKLSEDEINQELEKVEQAFIRILGLKPLYFRPPYGSYNDLVLNVLAQRGYKKVFLWSDDTGDASGESPSYSEGVLESVANDYPKPHLVLDHSVIQTTSTEVLPNSVWKLQQAGYQLVAVDTCLGDDGEWPYEYVGEPGTPDGSWTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L6S8</accession>
    <name>A0AAJ8L6S8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RIC1 C-terminal alpha solenoid region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_105202</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059181.1">
        <property type="nucleotide sequence ID" value="XM_070203080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L6S8"/>
    <dbReference type="GeneID" id="30172258"/>
    <dbReference type="KEGG" id="kpin:30172258"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034066">
        <property type="term" value="C:Ric1-Rgp1 guanyl-nucleotide exchange factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040096">
        <property type="entry name" value="Ric1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009771">
        <property type="entry name" value="RIC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746:SF10">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR SUBUNIT RIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746">
        <property type="entry name" value="RAB6A-GEF COMPLEX PARTNER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25440">
        <property type="entry name" value="Beta-prop_RIC1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07064">
        <property type="entry name" value="RIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIC1 C-terminal alpha solenoid region" evidence="4">
        <location>
            <begin position="787"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1087"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1112"/>
            <end position="1137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC71249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1137" mass="126968" checksum="DA64D9C58C333841" modified="2024-07-24" version="1">MYWPTATSRLVNTPSPLNSQPVRRLKSSRKGNFFVSLTENGLGVWDVRPTVLQAAVIRSSASIERFGHNVDVFWAHDGRGIIILTNTSHLLFYQLVPTSRPSYDSPGPSTPGPGEGDVVMGWELRCLGTAFVMGRCQSLVTQPHNLLLVLQHPPSILTVPYPIPIQLLSPAGSHFPPPPLDGDSESQIDCSIYDLSSNTEWLKDPLPTGITSFRIPGLPILYSLTNQDGRLYIMYQSSQLAQMTTSESLKSQLNNGPKYTGFRIHPPPKTSDLTKRVEALGLLRGEEDEGDVEDYTEQVAVNPRFGLVAVGLASGKINIISLPPYPAQPRLSHTLNLRMSANLHSSPGGVTSLAWTGDGYCLAAGYEKGWAAWSMGGRLGGWGVKDDDEGQVDQAVGVVDVFWAPGNLELFLLRPALDHSPQIEVVSFVKSASTSQQSPDNTRYAFLQMDDRVLVYRGADQPDMSVINPESDVWQSIKIPSAYIATNWPLRYASISSDGKLIAVAGRKGLTHYSASSGRWKLYPDERQEREFTVRGGLLWFHHVLIAAVDVDKTHQIRLYSRDLDLTEILHTQTLPSPVLVMTLLDNSLLVYTADNNLYHFLILPTQSSIKLHLCGSISFRGIVQVPSRVRGMSWMIPLAQKNLGDPVDDLIVATIIFLVDGKLVLLRPRRARTDEVRYDMQILADRIEVYWTHLHGVATLENSLWGYDGQNVRIWLDALTIEATRVNSTSDSYEEVEESVKLRLDFYPLSILMDKAIIIGVDPDSSLRLPWSIYKITTSTHLFLPQFLRYHLSSLPQPSLLNALILAKQYEGLVYFAHSLEILLHSVLEDEAAKSNTNNSISDLHTKHEEKMKEQFINLNSFPPTPNPEINGKNDILSAVVQFLDHFDNSLEVVVGCARKTEVDRWKLLFDIVGSPRILFEACLSQGKLRTAASYLLVLHGLNEDGAFVEESEFDKEERERGKVDVDDTIRLLKRAIKAKEYHLCKELLRFLHSIDESGHSLISAIEQIGILDQSLISSKTVSSDQNGGNTSVQSNTNEVGLNEEIEKIVNTPNILLSSEVSSPIHVPTSSPPLPISSEIERIKDRSEERINSPFQLNQERMYKTPPSPRTMERFEGDSPIEDERTRIEEKLENAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L6T3</accession>
    <name>A0AAJ8L6T3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Selenoprotein O</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_103848</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SELO family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC69905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058941.1">
        <property type="nucleotide sequence ID" value="XM_070202840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L6T3"/>
    <dbReference type="GeneID" id="30176170"/>
    <dbReference type="KEGG" id="kpin:30176170"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070733">
        <property type="term" value="F:AMPylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003846">
        <property type="entry name" value="SelO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057:SF14">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02696">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="611"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC69905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="737" mass="83785" checksum="52DE319A41F24B64" modified="2024-07-24" version="1">MSTQKLPIHRLPLPPTTLQHTLGQLPLEDKPSSQRRATTFKTTTDGIWARVNPLWASWPLRITKEEALSLGVDVEKGEQLNVEDVLSRWNLNKIEHTGIQHDSEEIKNELNTFSSEFRLKLNPILLGISTSTLKDVLPNLTVGDATTICNRGASPSPDSTPAALVRNALIDILSGRKVLQSENSENSKNNQTNYGPWSTRYCGHQFGSWAGQLGDGRAISILETQSEQGGRQELQLKGAGRTPFSRTADGLAVLRSGVREFLGCEAIAALDISTTRSLALLTTPFPELPVIRENGPEPSSLLCRVSPSFIRIGHFQALNPSKADQGMRQIFLGGRGWLDDQSVGTESEEGNLEGLLKLTNWVKDDIMGMQSNSVKEWLEEVIKRNAETVAKWQVYGWMHGVLNTDNISLTGVTIDFGPYAFMDVYDDKHICNHSDPSGLYNYRNQPARVLFALDKLATSLAPILGYEAIHSKVPFAGYSEALSKETRKEWEEKGKEVISGFEERFWEIEREVERNGWLKRFGLKTYKDSDDRDIFIDYLKLLQTHKIDFHTSFRLLSSFKSTQIDDSNYLDSFISNFLEETTISKCDDNLLNRSEEEFKNWFKIYAKRSCELEEKSKYNDLENENENWEKLKEKEMKLINPRFILRQWILEETIEKMEKLLTEPWINSKKGKEPEEWEIDLGIKEARKILAKILDMSTRPFEPYGEGEGKGSEFEEDKRLCGLGRKDMLGFQCSCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L6Y1</accession>
    <name>A0AAJ8L6Y1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-glycosyltransferases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_105215</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_070203083.1"/>
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        <property type="term" value="F:quercetin 3-O-glucosyltransferase activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:quercetin 7-O-glucosyltransferase activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Glycogen Phosphorylase B"/>
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    </dbReference>
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        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
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        <property type="entry name" value="FLAVONOL 3-O-GLUCOSYLTRANSFERASE UGT76E12-RELATED"/>
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        <property type="entry name" value="GLUCOSYL/GLUCURONOSYL TRANSFERASES"/>
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    </dbReference>
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        <property type="entry name" value="UDPGT"/>
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    </dbReference>
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        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC71262.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="555" mass="61896" checksum="5DE131893311737B" modified="2024-07-24" version="1">MTVIKPSHFIVVPTAMWGHLRPLLHLSLNLITLHPNLHLTLLVTPSILPRVEHELKSTSFAHIYTKSPPGPGTSSPNPDLHHITPQEQIQEDKAIADKLQIITCISPEFNLPKEWSAETMAQEGMDYAQTVPKFIKALVSKEHRLAEVENKYDDIPPNFLIYDTFLPFIPEVMRGVMSELQKPMLPLIGFVPSNAAATWHTFAEEETGGHFRLASRLIEEDIANGMDTAEAHVKHAFGTYGKVKTIPGLPPKFDWPNLATVPMPPQAFMGIIPSAKAAKDPAVHGLVCPTTAEIEPEAVEALEKEMGYRIYMAGPQFPESAWAGEHPEPKAKNEDDEKVFAFLDKMKKKHGINSVIYVSMGSLFFPATRPELIRYILKSLKDNGFPFVYAYASQMAPIPEDLQKELDDNEDSCAVKFAPQWDVVNHEATGYFLSHCGSNSTAEAILAELPMVSMPFAADQGEFTSLLSEIYKVSIDLKQVKTFRTPEFNKLYDGTIVVGTEEAIKAELKQTWDTLRGPEGEAMRERMKALKATIKKSWADGRSKKDMLALGTCFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L7K9</accession>
    <name>A0AAJ8L7K9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pali-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_105610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059258.1">
        <property type="nucleotide sequence ID" value="XM_070203157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L7K9"/>
    <dbReference type="GeneID" id="30171859"/>
    <dbReference type="KEGG" id="kpin:30171859"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051380">
        <property type="entry name" value="pH-response_reg_palI/RIM9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013:SF4">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="406"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="439"/>
        </location>
    </feature>
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        <location>
            <begin position="454"/>
            <end position="465"/>
        </location>
    </feature>
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        <location>
            <begin position="466"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="525"/>
            <end position="538"/>
        </location>
    </feature>
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        <location>
            <begin position="539"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC71652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="629" mass="68338" checksum="5DC12C27C9DB7171" modified="2024-07-24" version="1">MAIRFRNATPGTLVCLIAAALLAVVSFNTPLLKSLNFLKATYSSGQYSGEITLGTLGFCHTLDGTSTCTGPQVGYEFDPNDVFGVTIFDIPEAITKYLTYVLILHIVALAFAVLSVLCGLLAHSPTFAICWATTMASLASGITLLALIFDLAMFYIARARINNVSGASADIGICVWLTLAAWIILALSGCFFGIGSCCGGCRGRDEGGDPKRRNNKYDNNGGEEDYKMRMMAIDNERQRKLKQEQGLPSFQELVKDDGEDKYLIEPQQQQHQGGGLRRDGSVLQGVGMGYGRRSNKSPANDYNNIPGGWGGNNGYQTIAAPPPVARRLSDTTSAGDFVGVGAGGGGVDRPPQQQQQYGGNNGYYDEPYGSGNDQGHGGYGGQDQHHQDPYNQTSYNDPYSQPLHDQYNQPSSSYQQQDGYNPYSDPYRSSSTQPYNNADTYPPQVPIAMPTPGIQSSRSPQPQIQNAYDTSFGSTDSHYNDPGPQVRDADPYDGYDDGLGAIGMAVTGNNNTGRHERDYTGQTFGQNDQNNGGYNDNQIQPSYNLNDNLHQPSPQHLINPTQSNLLRSPISPIDNQRQDIIGTYNTGYENTQQPINQDQGSIRPPSYSAGDYAPAGGSQNRNEKSSYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L899</accession>
    <name>A0AAJ8L899_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_104621</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019153921.2"/>
    </dbReference>
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    <dbReference type="GeneID" id="30170525"/>
    <dbReference type="KEGG" id="kpin:30170525"/>
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        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015244">
        <property type="term" value="F:fluconazole transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <sequence length="528" mass="58767" checksum="32A641B51EAE6233" modified="2024-07-24" version="1">MRDVIRDSYFGQLVRLVHRPKWLRYGEESNDFTVPRFDRSGVEGYSEHGINVNSTTSVQAVDVNLVTWYEGHDSDNPRNWSLGKKCYVTFLIMILTITVYIGSAIYAPAVGPASEYFGVSTLVSSLGISMFVAGYGIGPLFLSGITEVPAIGRTSVYIITLLIFFILQILTALVNNFAGFLVLRFIAGFMGSPALATAGASLDDMYPSNKLAYSMGFWGLAAEAAPAMAPIISGFVIQSDGWRWAFWEMSILSGICLIILFFTLPETSPDTILLRRAQRIRHKTSNFQYQSQSEITHALLPFTQIIFDSLLRPIALTFTEPIIIAINLYTGLVYATLYSFFESFPIVYEQGYGWDLGVSTLPFAALFMGSLIGWSIYSLWNWKWVDQTFDPKGSARSPETRLPCALIGAFCLPTCILWFSWSAVRTHWIVPVLSSIPFGMASTLIFNPFLTYLPYAYPQYAASALASNDFFRSMMGAGMPIAAHPLFHNLGIDWGNTIIGLLSVAMIPIPFILYKAGPWLRKRSKIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L8H9</accession>
    <name>A0AAJ8L8H9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_106094</name>
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    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
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    </reference>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="46"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC72134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="91" mass="10593" checksum="3916D06466766EAF" modified="2024-07-24" version="1">MIVRRYSKVANLLQTMLGFLLCAVDMRLGVLAIVFFLWRHFTKLHDESLSDEKDAIEKEKKEIMEKLRDAKKAGMNSQEYMGLQMALERLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L8L4</accession>
    <name>A0AAJ8L8L4_9TREE</name>
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        <recommendedName>
            <fullName evidence="6">I/LWEQ domain-containing protein</fullName>
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    </gene>
    <organism evidence="7 8">
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        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
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        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="2">Belongs to the SLA2 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="kpin:30171990"/>
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        <property type="component" value="Chromosome 7"/>
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        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:clathrin adaptor activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:clathrin light chain binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:phosphatidylinositol-3,4-bisphosphate binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Cytoskeleton assembly control protein Sla2"/>
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    </dbReference>
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        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ILWEQ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030224">
        <property type="entry name" value="Sla2_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10407">
        <property type="entry name" value="HUNTINGTIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10407:SF15">
        <property type="entry name" value="HUNTINGTIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01608">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00307">
        <property type="entry name" value="ILWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109885">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50945">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="I/LWEQ" evidence="6">
        <location>
            <begin position="670"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="139"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="205"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="161"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC71518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="914" mass="102817" checksum="7E366F6C0D0D54E1" modified="2024-07-24" version="1">MLTRAPFFRFGRHHADYDDYPSVRAAASGANHQPTRPVDKDKTESELTVNIKKATSPEETAPKQKHVRKAHAQTGWLETCGRTVGDGGKGYGGIIKAYTSFLLSKLRFHRHHPEFNGLFEYEEYISLKNIDDPNEGSSPACFGLCTEEPPNLIDNGTAPELPERPPTEKPQARQETPRPSSPQATQGEIDEQRRMLEEYERKQAALVAQREGAQRRQEEDKRRQEAEYAEQQRLQQERERQAQEQLLREQMNQQYNQQQQGQVGQLQQEMLAMRGQYERDQMLLEQYDRRVKSLESELGLIGANVGAQMSAKDELISQLQKQIEIWRNKYEALAKLYSQLRGEHLDLLNKSKGFQLKANSAQEAIDKMERMERDVKTKNLELADMIRERDRARYDLDRLKSSHREEIDRLKRDLSFANERAEDASRHKSSEVSGVMAKYNRQLTELEDSLRAKQMQIDELLHKIDAKDSEVSRTIEEKEQELLIMQEGMDSTLKELSDLRLELNAIIDSILQACMQKVDDAIYELESPTQTGNTTATPEYTLSMIEKAMTNATEFASTFNLYLGRKSGGGHVDVIKAANELAQALSETLVSAKGITRFAETDEASDKLVKVAKEAGDSGYRFFLNLQSFRLLAGGKSEEAALRNNAETRGALSKLSDTVEKFIPKAKTSTLSQANGDIGDIVSQEMQNAAKAIEQATQRLQALMAQPKSNKYTSLDVQVHDAILEATLAITNAIGRLIQAATESQEEIVREGKGSSTTQQFYKRNNRWTEGLISAAKAVAYATGLLIESADGVISGTHSLEQLIVASNEVSAATAQLVAASRVKASLMSKTQQRLELAAKAVTDACKALVKQVKLISNKQVDDEAVDYKAMPSHEFKVREMEQQVEILKLEKDLGAARRRLGEMRRAGYHQETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L8T6</accession>
    <name>A0AAJ8L8T6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_105183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059171.1">
        <property type="nucleotide sequence ID" value="XM_070203070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L8T6"/>
    <dbReference type="GeneID" id="30172277"/>
    <dbReference type="KEGG" id="kpin:30172277"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="750"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="294"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="507"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="750"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="792"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC71230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="801" mass="87406" checksum="672E49DAFB2D6063" modified="2024-07-24" version="1">MNEQFNSSNELCEDHEGKTALKRCRAIISGLDGNSGEEELMDLDEIQYPEDQSLSSGSMFSHKTSLQNDYIDTTKQQDFSLISPLDSSSLVFDNANVHINSIHSDPSVNTFNTSTDNQATRSASSPSIIHSNSIQRNTAIPHNPSFIEQHALDLPSFEADIYIQANPRPLLSVKSSSSLTDNPPISRRTPISQSTPNNRPVPLRLGSSSASSSAASIRSARRLNQSPYIVPQTAKPTSSGSSSSYTMLSTGQVTVKDEPRTPVPLPSSPLYDIDVKQEDVEDVKTTPKLSLNTHSASRIGSSPGSMSMSHRRGSRPDFPPRLARQGSNNSNGKIDGSSNMRGLLTPLQSASSSSRQPPYPSPIPLTTAPLSPPPGTGHSHPQTKRYHQSPPSIPLSTAIPSTPNGKGKQSAYQVSLDEIPKDFVIKKLIQLASKYWYAPHSTDCHIIVPIKRASRSPVIPSTPRTAIPPLHQRHSTQPHVPQTANNGGPSHPTRLGDSFFGPKTPTAASIQAAAQSASPDSAEANNKPDVLTSSVTTLEGFKDGDGGRRGSLPGGNQLEQCLVFPLHKDYLTTQSVLFRTLLNSQAAHLSNPHPRDQDGRLIFQSPVIRGAKVLPTKSDRPKALYVPLPDPSSFGVILHWLYWHDIDHFNHCLSKGLVTWQGVIRNIEYLSLDNEIKLLAGKWWKRWVKPTEDIERKTLNPKLKSKSGSIATLKSIHRTHQSKRRAFSTSAAVIAKRDKLANMMMNIDHDEDEDEDDLDDEENGSDSGEEADDEDIVGPAKKSNLDGFADNVSLQLGNLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L903</accession>
    <name>A0AAJ8L903_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_105686</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059269.1">
        <property type="nucleotide sequence ID" value="XM_070203168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L903"/>
    <dbReference type="GeneID" id="30171780"/>
    <dbReference type="KEGG" id="kpin:30171780"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053013">
        <property type="entry name" value="LAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815">
        <property type="entry name" value="LYSINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WWC71728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="393" mass="44665" checksum="8B6022B2025D2254" modified="2024-07-24" version="1">MSMFKDTANLANFTIRIANELQGIQHLRAGWEIWKKDNTFEKYHTMAMKERNESPWGNDGKYLTWVLVRRDDMDGQIYAGCETYLRKGFVKHKDSNKVEDTFIYTIASVVTPKPYLRNGYATRLLSLLHHQLSNLPPPPYSFGSLPEVSATTIPKAIGSMLWSDVGSTFYSKCTSSSDRPGWVVEKPLVTELIWKILPPQSTKLDDGWEWLYLDDLPSIGAKLSNAAKLDLSKRDTSQKTLFQHDPASEGTLSFIPTKGMWQRPLIEDPEPVGLRFIPSDSQEQETIIIFSMRMINIGDRLLITYIHNLSPPQLPTVLKAMDILGHKAGQTEGWIWGLSASRPNLVKTWQGLEDRQVKTGQRQEIDGHLLGVAWYGPLEENGELIDGQMWTWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LB16</accession>
    <name>A0AAJ8LB16_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein mS41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_106849</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS41 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC72885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010043.2">
        <property type="nucleotide sequence ID" value="XM_019157325.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LB16"/>
    <dbReference type="GeneID" id="30173974"/>
    <dbReference type="KEGG" id="kpin:30173974"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039603">
        <property type="entry name" value="Ribosomal_mS41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019083">
        <property type="entry name" value="SAM_Ribosomal_mS41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28235">
        <property type="entry name" value="PROTEIN FYV4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28235:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09597">
        <property type="entry name" value="SAM_Ribosomal_mS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01238">
        <property type="entry name" value="IGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small ribosomal subunit protein mS41 SAM" evidence="5">
        <location>
            <begin position="44"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC72885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="133" mass="15141" checksum="988540987CB652B0" modified="2024-07-24" version="1">MFLPSLRASSSKLPVILTGQRSLSSTTRILQKAPLQASAETPTPQSLLSLIGRNADTKLEAHSESWEKLNELWMKSVKLYDVGLSHKERRYLLWAFSRYSQGSNPSSFIRPPRPPKKFRGWGPKIQHGVRIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LB65</accession>
    <name>A0AAJ8LB65_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_106377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008012.2">
        <property type="nucleotide sequence ID" value="XM_019158874.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LB65"/>
    <dbReference type="GeneID" id="30175549"/>
    <dbReference type="KEGG" id="kpin:30175549"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051058">
        <property type="entry name" value="GDSL_Est/Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648">
        <property type="entry name" value="GDSL LIPASE/ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648:SF22">
        <property type="entry name" value="GDSL LIPASE_ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC72415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="424" mass="48597" checksum="25B0D3553B066C60" modified="2024-07-24" version="1">MSRRHQSTSELMFPSRKVMRFCVLSIFIIAGVWVFTMKADLTSPNQGQRLMKRGLSETSNEGEVDLIDDFVNTFPKIRTWQETGVPSPTAKYVNRNEQQLIIGHEDEMEVVSSKREPFDWPRSRKLFVFGDSFSTRDKDYRKDGIDGGHFQELHGKATDMKWADYLYAVFHDFHILQYWNLAKVGATIHHSVLPPGLESYGTFETQINDFQDLFTPLPGPNQVNWNSNDTLFIIVFGINDNGRLNRDDLHEGGTLDVESTTKALVNSLMEQSKRLHGLGARNFLFMTLPPLHLSPKYKLPSQVGHDIVNRVEGSVNHFNTFLRSGVKQFERDMDDSNVMLFDLNKFWKLLLEYPELFGITDISRFRITIDGRLPNFGRMGLAYHDNQHVSWSSAELIARSVNGLLMRNSASLQMSNASQTEYTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LC14</accession>
    <name>A0AAJ8LC14_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ATP-binding cassette transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I206_106447</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059420.1">
        <property type="nucleotide sequence ID" value="XM_070203319.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30175620"/>
    <dbReference type="KEGG" id="kpin:30175620"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003757">
        <property type="entry name" value="Chromosome 1, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF415">
        <property type="entry name" value="FI20190P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="427"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="450"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="532"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="563"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="995"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1101"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1182"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1287"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="292"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="682"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="1103"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1385"/>
            <end position="1658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="642"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="937"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="642"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="669"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC72485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1682" mass="186041" checksum="797D2098B6C698F2" modified="2024-07-24" version="1">MNAEANFQAFSPLIISSIRTISSLSILILVFIVSLPPFKPIRRFFHSLLSDLVPLESLVPPEPPTERQRHEAIKRRPAIWKQIILSLISIAEIGVWTGITGWQIMGLAHRDGHKVTDILLSAGMIVVWLYFLLQFTIRPLYTPSYTTILILSILLVLSVLSLGNAWYLKTINNEFPSWATKTRNGLEIGDIAGISIILIVLFGLKITSPEVLSRLPEVSLDDDVTLYSWLSFNWVNEFIAFGASKELDPEDLPKLSLKQQTAIVFDRFNQLKTSSLLKQIFLANKLDLGSDAALTLLAVVFNYAGPYFLKKILDGIDNKSARAMSQAYIFAFLAFLASTLKALVDLLHLWHGRRAALRIKAELTAAIFDKALRRKDASGIVTTKEDEEKEAKEGGKAEKKSNADSGKVVNLMAGDTNRIGNTVSGGYFIYGAPFEIIVASVFLYNILGWSAFAGVVVLVVATPLNSFVSKRSIAITQDLLKARDKRIGVMNELIGAIQFIKFFAWIEQWKNRAAEARAKEMKQMVRSLINGIWFSLLWSLAPIFVTLVSFFCYIVIAKRELTVSVAFTAISLFSMLRMPLNVIPTFAVILLQAHVSVKRIEDFLAEDEVPDWVSSLKRSVDPKDASPNEIGFANASFRWNTGKQSEQNASASTEAAKKPKTIVEPPSPSQSTSTTAVDSSSSPQDDRNEDGEESFFTLTDLNVSFPVGKLTIITGPTGSGKTAILTALLGEMELLNGKSYLPKNTTQINSDGLRNSIAYAAQTPWLQQKSIKDNILFGEAFDEARYEMVLDACALNPDLDMLEDGDQTEIGAKGVSLRYVSRLGMFVEAWTDQRSLHCSGGQKARVALARAVYSYTQHVLLDDPLAAVDSHTAKHLTDKCLNGSILKNRTIILVSHHVELLLPSSDYLVRILDGRIDAQGTPDELRSAGELDGLVALEEAEVTKSEAIVAKEEVEEEVEVVDSAEKKVKKKGPGKKLIQDEERAVGNVKWETYKLYIVAATYVTWVWTLLVLLLNQGLTVGERWWLKVWGEAYNTQFTSHTTLFAVFRPAIVDHAQHYHHTDLHQHVLHHTSSAMVSNMTVGATAIKGLRSYFPPAQTNPGFYLSVYTGIVLGAALFGVGSSAVGSWSSYRAAIHLHDRLLERVMRSTVRFFSVTPVGRIINRFSRDVETIDSSLNGALRTVIIYIASLIGAIVVVAAIVPWFLLPAAIISYLYYQYSIVYLRVGRSLRRLEATLKSPIFSGFAELLDGVISVRAFSVEARFMTQLCEQVDKTHQAYYYYWMMNRWLLIRFDVLGAISVFLTTLFALSGAVPAGSAGMAIVSAQSFVLACYWVSRFWGQLEMDFNSVERVQEYLSLPQEPPAVIPRNRPPAYWPSTNASTKDQFLSVRELEIKYAPDLPSVFKGSFDIRAGEKIGLIGRTGSGKSTLAMSLLRFAEPYGGSIWLDGIDITKIGVDDLRSRITYIPQDAVLFSGTVRENLDPFNEHTDEELLDALSRVNLGPADTPPSSRVPSRVPSSKRLAALAAEDAKRLASPAPSGSTGLGGKSIITLTTEVSAGGSNFSQGQRQLVAMARALLRKSNLIIMDEATASVDFATDEAIQAAIRSEFKSSTLLTIAHRLSSVIDYDRLLVLSDGRVAEFDTPINLLRKDDSLFKSLCEKSGKYKDLYKAAEKKEKDDGEKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MMG1</accession>
    <name>A0AAJ8MMG1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_101460</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0014 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058492.1">
        <property type="nucleotide sequence ID" value="XM_070202391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MMG1"/>
    <dbReference type="GeneID" id="30174937"/>
    <dbReference type="KEGG" id="kpin:30174937"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005226">
        <property type="entry name" value="UPF0014_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30028:SF0">
        <property type="entry name" value="PROTEIN ALUMINUM SENSITIVE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30028">
        <property type="entry name" value="UPF0014 INNER MEMBRANE PROTEIN YBBM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03649">
        <property type="entry name" value="UPF0014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC67551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="306" mass="33535" checksum="6F82222A3A9ACDA6" modified="2024-07-24" version="1">MIGSSPTLTWLNVLIGFLFILFDSLLSLILGLGIGGSLIVAAARCILQLSIMGLILDKVFASNNIWGVFGIAVLLNFLGAFEATYNKSKRRFNNMFPLILASMLSATVPISILGTRFAMAQNPFWQPDQYVPVLGMILGNAISAIGIALNSVHKEFSENKDKIETYLAFGASRFEACKPVGKEALKLALLPTVNQMSVIGLISIPGMMTGAIVGGKSVEQAAKLQMISASSALSVLLALCFSLTTLVDSRCRIRPDRLDSRKPIFYRYRDAAGEKIWKGIKSLKFWGRKERGSEEERRGLLENHRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MMI9</accession>
    <name>A0AAJ8MMI9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ZN622/Rei1/Reh1 zinc finger C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_101551</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058511.1">
        <property type="nucleotide sequence ID" value="XM_070202410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MMI9"/>
    <dbReference type="GeneID" id="30174846"/>
    <dbReference type="KEGG" id="kpin:30174846"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040025">
        <property type="entry name" value="Znf622/Rei1/Reh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182:SF8">
        <property type="entry name" value="CYTOPLASMIC 60S SUBUNIT BIOGENESIS FACTOR ZNF622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182">
        <property type="entry name" value="ZINC FINGER PROTEIN 622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZN622/Rei1/Reh1 zinc finger C2H2-type" evidence="2">
        <location>
            <begin position="149"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC67641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="408" mass="45612" checksum="6C4A322D74F6D09C" modified="2024-07-24" version="1">MFTCISCRVAFETAAEQRSHFSTDWHRYNMKRRVANLPPVAAESFNEKVLERREQNAVRTDPRSLVCSSCKEAQQPVDRGVLASTSSSPHTTAPAFLESTSLGETTAYNRQVALEEASSSSVISSDDEDDSGDFAARIAKSRRRIQPTDCLFCSAAQASVDHNVAHMAKQHSFFIPDRDILLDVSGLLSYLGEKVAVGNLCLYCPNGGREFGSLEAVRRHMIDKGHCKLAYETDEDRAELADFYDFNGSEELIDSDWEDLDDDAPDDHQSQDIMEPYARQRPMALAADGLSLMLPSGRTLGHRSLKVYYSQRLRPFAQRDTTSSINASKIAHIRQRLADPSLALVPVAGGHGAFGRGQELMKARNAGEAKWARRQGRSFKDQRIKENMKTRVGFVHNNQKHFRDPLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MPG8</accession>
    <name>A0AAJ8MPG8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Calmodulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_102563</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calmodulin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058687.1">
        <property type="nucleotide sequence ID" value="XM_070202586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MPG8"/>
    <dbReference type="GeneID" id="30171282"/>
    <dbReference type="KEGG" id="kpin:30171282"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000006">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000398">
        <property type="entry name" value="Calmodulin-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="4"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="40"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="77"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="113"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC68632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="145" mass="16331" checksum="AA605A8891A12684" modified="2024-07-24" version="1">MAEQLTKEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTQAELEDMINEVDADGNNSIDFAEFMTLMARKMHDTDSEDEIREAFKVFDKNNDGHISAAELKHVMTNLGEKLSDAEISEMIREADKDGDGMIDYNEFVTMMMAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MQ93</accession>
    <name>A0AAJ8MQ93_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_103381</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058849.1">
        <property type="nucleotide sequence ID" value="XM_070202748.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30169983"/>
    <dbReference type="KEGG" id="kpin:30169983"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000146">
        <property type="entry name" value="Putative two-component response regulator SSK1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="1062"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="380"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="667"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="769"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="884"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1276"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="402"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="670"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="772"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="890"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="925"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="982"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1300"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1316"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="1111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC69442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1361" mass="146597" checksum="F1469750731F79AC" modified="2024-07-24" version="1">MSSSSNPPVTPLYIPGSSSRSPTTSISNSPHGGTPQSAIISYPIDWNNSRESSMHEGTSIDNDLFKGDIEPPIPMSASSSSSSSQPIFEWPSRSSQPSAYSNLNRLGNHPSDTFEPHSSSSEDDVNAYPLETRRGSTFRSTTDPLLHDDQPIDPEFIIGPPMDSYNFDPPPAFNRTFSSPLPQRLGYLRHPLSPASITPAPPPITSFTKPPLTAKPAPTALHSVSLEFADSLQSAIQTLLHLSPPHLLDNAKEQYSGCTVQVPATSLSALLTSMRGLNFLSAHAEQLVEGPDQGPQMRKGDDFDIGELLQNVADMLSGQASQQAVDFVLFHGDVGIKHVSVTGDGEGLSYTLSHVIRQILLVAHQSDTIELGLQVIPQSPSLTPRIGQPLTDAEIDKHRGTKSASGSRSNSPGRTSLQPPGPNEGPLLCVFEIVHNIFQSIDSTHVTPKAELNPFTKLAEAAESVKPNFNTTLCRRLLQAQNASLRVDVQPSSPSGTGMPRRAYELSILLPRGRPIVEPTPLSTEEEAVRQPFSSVRLAREPTLNELSDFAESLRTKKVAIHANLSSVFARHLTSYLAAWGMDISHIPIDGDEIDKAKALLPTGRHDSGYGGSTAGSTPAGDIPMSLAPSFRDQGRFIIIDDDITVLRKELFRIRAELHPLSLKPRLNKRPSLSSRTRSTPHVRQVPQHRPVQSAILIHFTSLAKYNQVRDVVSSFVGAPWSTGSGAYVQPEVMVIPKPVGPRRFLTALHTAVNQPIVDPFFSPIATSPRSPGGGYFGGGGARTPTDKERDTGFFDSVAEESTEEHIGGGSQKPRSPLGEHPPSAAQIVRTDQGLHLSLPTPGEILATPANEYFSSASKATPLGSGASGVVMQSPDGRPYGMFFEPPIRNNERRASAHRIPSDSLRRKSTSRRTSAGGEEGTASPAISPNTSRRVSSASNISGPGDDKRGSTVGISERPGHARVNSRRRTLPVSEAPIVAVGRDRSATVTRDSRKATPGHSPVIPSPRSDQSGFPTPARQLKKGPVPAAAAMEVTEQETKKVSSPRPAKKVDKNDVVVPPINVLIVEDNPINQNILSMFLRKKKIKHQSAKDGQEAVEKWRTGGFHLILMDIQLPVMDGIEATKEIRKMERTNNIGVFPSTPSIEHVKTLSPEGPMPASPFRSSVIIVALTASSLQSDRVAALAAGCNDFLTKPVSLKWLDKKIVEWGCMQALIDFDGWRRWKSSDPKEASEMKKGFTLGPQAAAKSLASRLRIERKATRSPTPAPAAPQVQIQVPTPEPTEGITPSTLPLAPPNPPPLTESTTNPELTKALPSVQEVSESTSPLAKQIGLLKLDTDTGDESASTPVTFTDEKPLPPLPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MQK2</accession>
    <name>A0AAJ8MQK2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-hydroxyisobutyryl-CoA hydrolase</fullName>
            <ecNumber evidence="2">3.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_103972</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20888"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57340"/>
            <dbReference type="EC" id="3.1.2.4"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.2.4" evidence="2"/>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011142.2">
        <property type="nucleotide sequence ID" value="XM_019156184.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MQK2"/>
    <dbReference type="GeneID" id="30172823"/>
    <dbReference type="KEGG" id="kpin:30172823"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176:SF3">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="5">
        <location>
            <begin position="71"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC70028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="528" mass="57707" checksum="D3153F946AAEC78E" modified="2024-07-24" version="1">MSSLTRLSLRMGSSAGSSSSSRIAANRLSNISRHLSTSSVASDQATQGSASSKMPSPHDELVLFESHHNARLYKLNRPAKLNSLNQEMIDLLSQKIKIWRELESCKVIIGTGDQRAFCAGGDVKQLVLDLKDGKDTALPFFKSEFELNWTLGRLGKPYVAVIDGVTMGGGAGLSLPADIRIATPRTIFAMPETKIGYAPDVGSNYYLAQLDGAIGAWLAVTGQELYGRSVYELGIATHYVTPNLLPTIINEITQLDTPTSAQISSIISSYTASVGSGESSKTNPDGLSPIKGEIREFLDNTFSLKSIAEINEALIKSQNDSSLSGEVKEWAKVQLDLLNARSPTSTAVALTGYRKAKESRRLDRVLLNDISMATSFCGPNRSTEDFIKGVTSVLIDRSKQSPEWIPSNLKDKKLNLSEIIKNFYPTKSSDNTPELKLIPESASKLDSGRDSTWNKFRKFGLPSEQSIKSSVDGYSPQSGAFALTEKELISQFIEDSINGTRRDEIIERIKNVVSKNCKVDKGGYLEWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MR02</accession>
    <name>A0AAJ8MR02_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_104157</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010963.2">
        <property type="nucleotide sequence ID" value="XM_019156005.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MR02"/>
    <dbReference type="GeneID" id="30172637"/>
    <dbReference type="KEGG" id="kpin:30172637"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="47"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC70207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="551" mass="60362" checksum="2B6541BDC688DC88" modified="2024-07-24" version="1">MEKNASAAGSVEDAKGVYPDIAIIDASQETDRPAQTSSTVRGLTLKHIQLIGIGSTIGTGLFLGCGRSLIAAGPLGSLLAYLIFCAICWGVCLGAGEMGSFKPVPGGFISWAGDYVDPAASFAVGWNYFYAGTMFGCADIVGVAGLFGYWLPDVTPAAWITMSIVIIFCLNAFHVKFYGESEFYFASLKIILIVMLILMAFIVMLGGNPQHDRIGFRYWKDPGPWASYYKQGALGRFLGFWNVFKIAAYSVGGPEFVSMCAGETVWPRRNIPKAVKGVLFRLTLFFFFGILACGVLVPYNDPLLAKAIKSGVGADASAYVVGMKRVGIKVLPDVFNAMVITSALSCANGFAFVGSRVVHSLAVRGQAPKIFARTTKHGVPIYALLVVLAIFCLCYMQVSTNAATVFGWFINLSSVAQLLNYVAMTITTLRFRAGLKAQGISRHDLPWTTKYTIPYSWFCLVMLTLIVLTQGWTVFVHGGWDVQNFLTCYFGIGFVFVAYFGWKLWHKTKIIKTDEMDFKSFVPEFDALDDEYRAAHKVPTTAIGRAFDRMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MSS4</accession>
    <name>A0AAJ8MSS4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VPS9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_106536</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059441.1">
        <property type="nucleotide sequence ID" value="XM_070203340.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30176293"/>
    <dbReference type="KEGG" id="kpin:30176293"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF25">
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    <sequence length="1355" mass="143965" checksum="0E44A86436B30570" modified="2024-07-24" version="1">MSDQPRSSLFSSLSLGRASRSRPSNETLAHPLLGASTSSLNLPTSDSMSIESSAPHLTHRTSSSFSSKGGSAEMPNLPYKPRQRHGGGIGSAGSATSIFGSANTASPTLQPVNPTISTSPVTPTTIVSAPPTTSTSTSTTFALPPSTSETSIQIDSSALTTAPALAASSTLTSRLQIQSLKAAAQRIGLGNGSMGMSMIDAIFDKGQLGRAKAGEGGDWGDLLRILMGGKAILLLPTTPSSSLPMTPQTLRDHVAFVAPPVPLASSSYTSKQPGNSSQIFNIEKATSNECVSVVVTLSGLIGTIRDDLITFESSVPYESPLIRDLRDASTRQSVLSSLRPTHALSSTASSSSFPSFTVSKDTASLPFPPPSKTTSIHISNENKEKDKPPPGKLGRINPFASLFGSSAPSPAPGTSPSNTHPPLPSPPDIKTDNTLTPDQPLSPSRVHGGSRPSSPSPASPKPASILTFDLADTTSILSDTASVSLAHGEGYQVTAYTVSRPVRYHETHKSLSKAIRLHIREVLAKLPDKVLDKVVKLVLANACPSAQGDELSKSHKGHENENIAILDFYDPTTTGERLQDFMEGIYDDLISHYRAESHDGLKRKSSGNTPWGRTHSYGHAKSAEGGEEGVKEKKEQDRLDREEMVEREASEGTEKVEAVVCRLLYNRLFSPLESDDARHDEALASRIAALNMLDLSLDHLGLITRPESEVPEGTIAKGLADIVEAVGEELQQLSGSDCLTPRDKAKVLITAHKLVADGLARMPIVELRPEGEPYKPPQSEITVDALSNNQAEVELPTLSTPENQIPRFSPTDSQTAPHVNDDSSPAASESSDPLNVLGGEAEATPQPKLAKSPSIPQLTLPDSPASPNGDTEQDRLQEAMSDSVMTLTPATSRDASSSTDKSIPLPKPASLKSNTDKPATSGADLILPIIIYSVVKSNPAQLASQLMYLRRYRSAICLTGEASYAIVNLTAVVEFLEHVDLVELGLGGESDRVMSIDDLSPIGLNYLDESNADAASIASASSRLRGRVFQVGEMAGTAAGSANKVITGVMDSSWTALRGLMGTNPNFPQDGEPNEMENGETKNAVRPEMRPRGASTFSLASVTASVASIAAAAAARNRSRASSRASEQVWGGNQELQEVSSNSRPASIKERSNEYYPSEDEEDDTVSDSSEEDEEVKPVTVEENSAKEKEKDTKERISLSNRLASIGVLGRLSSPANAPNNGEGDSRNMEETMPNPVPSKASSFLANLTPRSISSSLPSTSHSPANQETKTHTRRGSLLNNNSLELIRSHSPRGSISSLPMTKDNSGTELNENAAPLDRFMNCEIGDIKISEIGILLRDYRRLGNIVANLQKNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MT93</accession>
    <name>A0AAJ8MT93_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">U3 small nucleolar RNA-associated protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_107583</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the HEATR1/UTP10 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_070203550.1"/>
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        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
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        <property type="entry name" value="BP28_C_dom"/>
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        <property type="entry name" value="HEAT_type_2"/>
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        <property type="entry name" value="HEAT_Utp10/HEAT1"/>
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        <property type="entry name" value="U3snoRNP10_N"/>
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        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 1"/>
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        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HEAT_HEATR1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="U3snoRNP10"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 9" id="KW-0698">rRNA processing</keyword>
    <feature type="repeat" description="HEAT" evidence="8">
        <location>
            <begin position="840"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="domain" description="BP28 C-terminal" evidence="10">
        <location>
            <begin position="1734"/>
            <end position="1886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00010559"/>
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    </evidence>
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            <dbReference type="RuleBase" id="RU367065"/>
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            <dbReference type="EMBL" id="WWC73611.1"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="2019" mass="223916" checksum="B08A2E74CC0A83DC" modified="2024-07-24" version="1">MSSLAAQLQGIASLDASRLTSKYGQPSSKSYLFPPKVASTHDLDSIYALAQSGFEEILSLDPEMEQYESELFSEKSKRTDRMMLTQEENDELDFLLARCLRRLGKWIGIMAGGKCIEWLVRRFRVHEMNAETLLQVFLPYHESPNFPRILSILTLPQTSTYYAPFFPLIKNAQPVSRSYITTTISPARDKSLKLLGDVATMVQQAVKEQAVHRSLLTFWTATMVDLVESGKQGKGIHEGLVKIMVEAFVTILSTKNGGEDVNAAVYPPLVLLTRSVYLTDEAFHALVSSLLTSTSGANSSQRILTLLVILNDRPGYAAGLGEHAAENLSKIKQLDQILVAAMERYGFETALKTVVAVILEDPETHFKTTRAVLEHRELPKSIAKLSASALLRLGSDENTTEETKDIIRSLLANLRERHPNIVDSTYIEATTTAEIDHQLVQKPADESAYLNIYAADISSRIQGVKEVIQLYQSGTQDESATSALLARLGDTEEAVIQAIYEDPEQLLEITFVEKYISGVKSSFWSTSPDSTILGHHLNYISNTLLTDKVLTKYPNVGRQVFQELLFPVILASEKRSPLNKASAGTIFGGGFKGIIEFSKFTTEIAKARSDDNHGILAKSNVLIATALADAIQESSHFEQDIKFLITQIDARNASARLLSHLVLAQLIACGNRAKQITAAHRVLRHIKHSHIASLKEIDNAEDIFSSSYIDAVYRKTTDIRTSQRAFLSLLASITKVRKSTNPITWLQEDLAAPEESAPYKLIANEVYNWSNTGLLPKPLASSLLRSLFAQIGEDALLFFASIWTGQSESTLRTASLRHALAFVSAYSGVKGQQGIDFQIMLPSIVIALQDAEKQVRSAAVDLLKAMSENAQSSENIYALDTVYGDKSDTVQLLKPSDRKKYLDMLIENSDDITVDSGRIKTILYAALVIVHGKNKKETAHRRAVLGCLISHIVSHRSIRDRLTLLRLLVDIHDHSILRGLLPLLLVLQDEKHHETIWLNSLEPVDRKDYLALLFSAVNKESVSVLADQQAGVWNFLLSALHTEESSALLGQLREISFKRMVDGVFETLPTAQKIEYTLAIIQSLHNLSSEESLATSKLLQSFKLDTPGVVEVVEQLAEPLETTVHRKKQRNDDHEDDKPTSAVIDLTVLIESRDWKVLPGDATLVASLMSILSALLAKRQYITQGVDYLEQEVLAAILALVEKIQDPQEIGRAHVGIEVIIKVIRASTNPRTSQRALLVASELARLIPEAVLHNVMPIFTFMGASDFQRDDAYSFGVVEKTVSRIVPVMTKSLKEKAANSLELYNESLTFLSIFTDMASRLPKHRTLPFFIHLVKSLGPADFLAPVCILLVDRSTTKAGRAGNPVAIILELPSSLVSTFDVSIKTEVLAEVVNELTRLVNDLSESDKEAFLSRTISENDSSDRSIKQINHLLTFTLALIDQLKGKQCAQVTVQNVVQKLIQLAAKSANVSLASTDISKNVQAALGGAMQLLSAENFLSIVLHLITDGTDKDTVMALNTFSDRVSLIRSDIRSKCTKAIGDIIKRSSSLLGAASDTTKASLVAIKTVASTALPAEDSALASVLPALVGSISKTPESNNVISSLDLIELLIKHLGSRIIPYIQSIITLSLNLINSSKTIITITKSSFSVISALIETVSNFISSKQLLNILNSTIDYRSKDLNISLKVSTTISKKIRTKTLFPVLLDLWKSTQNEENSETIKGFFDLLRLTLKNSSRDELPIMMKSIFAFFLDVFDLRNRLQSRQVDLDVINDIEESAIGSFLELVTKLNEATFKPLFIRLYDWAVIDLAEGKAIDDGRLIERKIVLLHVMMGLLVKFKNLLSPYMAILLPHIQELLPAYSEGLINHKGLHNLLLDVLSKSFEVDEGTYWSDQLILEILPNLISQISLDLNEEEKDEDLTSLIECFGNLSNLINSENVLRKLNQSICLKTRSDNIKIRLTSLKILNKIWEKSINELISFVPETVSEFLTELLEDESNDVELSARILLNKIEKVTGSLKEYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MUH4</accession>
    <name>A0AAJ8MUH4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_107839</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Plays an important role in cellulose degradation. Shows hydrolytic activity against several glycosidic compounds.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059706.1">
        <property type="nucleotide sequence ID" value="XM_070203605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MUH4"/>
    <dbReference type="GeneID" id="30174540"/>
    <dbReference type="KEGG" id="kpin:30174540"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080079">
        <property type="term" value="F:cellobiose glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000011">
        <property type="entry name" value="Cytosolic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF36">
        <property type="entry name" value="LP05116P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC73867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="461" mass="52499" checksum="848F3AFE8695BC79" modified="2024-07-24" version="1">MTVTTTFRRDFLYGFATASAQIEGGGAESEKESGRGDSIWDAFCEQPDKIRDGSHVKKTCNHLAMYKEDVAMMKSLGANAYRFSISWPRIIPLGGKGDPINQKGVDFYNNLINECLKNGLVPFVTLYHWDLPLELFKRYGGWLNKDKIVQDFTNYARTCFELFGDRVKHWLTFNEPWCTSVLGHGIGEFAPGHVSNTEPWIVGHNILISHASAAKLYINDFKPTQGGKIGITLNGDWTEPYDESPENIEAAQRKMDFALGWFADPIYLGKYPQSMIDILGDRLPKFTKEELALLKDCSEFYGCNTYTTNTIKAEKSDDEFAGYTTMGFDKPDGSMIGPPSQLGWLRDVPWGLRKLLNYLHQRYKMPIYMTENGWSIKGESLLSVEDAVRYYQGYTQALKDAVEKDGVDVRSYFGFMDNFEWASGLIPRFGSVYVDYDTFERTPKDSAKVLMEFFQDNISRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HSM2</accession>
    <name>A0A1B9HSM2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_07750</name>
        <name evidence="8" type="ORF">I206_103801</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.</text>
    </comment>
    <dbReference type="EMBL" id="KV700118">
        <property type="protein sequence ID" value="OCF46273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC69858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007492.1">
        <property type="nucleotide sequence ID" value="XM_019159440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HSM2"/>
    <dbReference type="STRING" id="1296096.A0A1B9HSM2"/>
    <dbReference type="GeneID" id="30176119"/>
    <dbReference type="KEGG" id="kpin:30176119"/>
    <dbReference type="OrthoDB" id="8191639at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF45">
        <property type="entry name" value="RNA EXONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exonuclease" evidence="6">
        <location>
            <begin position="13"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCF46273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC69858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="190" mass="21712" checksum="DAE51588B1A296D3" modified="2016-11-02" version="1">MITSKYKLPNLDEYLAIDCEFVGSKRGNELAKVGIVNYQGSIIFESFVYVNPRNVIDYRTSKSRIRAKDLEGAPTYEKVIIIIKDILKNKIIIGHTLFNDLNVIGYKISYDSFRDTALYIPLRRKVGINKEGIYPSLSNLSKKNLGIDIQQNEHDPIEDARSTMAIFMKVRENYEIDLIQNKDCISGIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HSY2</accession>
    <name>A0A1B9HSY2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_07611</name>
        <name evidence="13" type="ORF">I206_102241</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894017">
        <property type="protein sequence ID" value="OCF46377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007596.1">
        <property type="nucleotide sequence ID" value="XM_019159302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HSY2"/>
    <dbReference type="STRING" id="1296096.A0A1B9HSY2"/>
    <dbReference type="GeneID" id="30175980"/>
    <dbReference type="KEGG" id="kpin:30175980"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF77">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="29"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="521"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="521"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="547"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCF46377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC68316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="575" mass="63001" checksum="5F692BA89DB44118" modified="2016-11-02" version="1">MVAAISGGDQGLDSWGDFLKKEYRRPIFFCALIAIAPIAYGYDGTYFTSLLETPVFERQFGDYDAKSNSYSISSSDQSLWVSIIQVGEVVGSLAAGPIGDYSGRKGGMLAAIILLAIGVVLQMIVIGSSALLTVGRLIAGAGIGIISNAAPLYLSEIPPVEIRGACVSSWQLMLAIGQVIGACVGLGSHNRSDTSSWRIPIAINLVWVVLLFGVLFIVPESPRWLLYKNKDAKAEKALRKIHAGSEYQDLLVQEQLAIINKSREEEAQASSSQSRWSDLWRNPVERRKFIATVGILVSQQISGVQFIFSYTTTFFTLVGLKDTFIITIIVDCIEVLGVLASFFVVNRFGRRPLLLYTGIFMLITLLVVGCLGAVAGQGTRFEPYLADHPSFGKAVAAMICLYVFAFNVAWGPLAWVVAAEMSTGRNRQKHLSIGTALFWVSAWAVTFTLPYLFQPNEAGLGPMIGFIYSLGALASLLFVYFFIPETIGRTLEEINFMMEARIPTRQWKDFDLATVVAKDEKKGTRGTTEHVETTNNGQQGQAALASKPEKPRTRRFETSFINKKTAEQIAESESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HT34</accession>
    <name>A0A1B9HT34_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_07659</name>
        <name evidence="3" type="ORF">I206_102289</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="David-Palma M."/>
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                <person name="Mohammad A.W."/>
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                <person name="Yurkov A.M."/>
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                <person name="Litvintseva A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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    </dbReference>
    <dbReference type="Pfam" id="PF18210">
        <property type="entry name" value="Knl1_RWD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MELT_2"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="Spc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00787">
        <property type="entry name" value="Spc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="609"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="405"/>
            <end position="618"/>
        </location>
    </feature>
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            <begin position="844"/>
            <end position="878"/>
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        </location>
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            <begin position="516"/>
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    </feature>
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            <begin position="601"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="Coils"/>
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            <dbReference type="EMBL" id="OCF46539.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC72755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1116" mass="123195" checksum="95D0319AF4570D43" modified="2016-11-02" version="1">MSIPARSPRASRKSISLGEKDLNLDNVTLPVTNKEFKAKKRGAVSFGGEGLGEGAFQVGKAGAGLSPRRQARRIAQPRKSILKSLSSKNDESEDTAQYAHTIAFSASQTMLSRRVSFAPNAHVRMFEKSPMIMSPDGTPAAIITLPPPSSGPRAFITAIPSHSRRSSIQSIGSVSKPNIFAPSIFEGEGASQGEQSMEIEEDDESEDEGIVQMGRQNNGQQVDTLLGTEQADGDSDEELEEDEMDMDITQNIYGGIVRRASMAPTTVGDTTIDSDVTEEADITTRSDEEKTMDFTIAVGGLLPPQAPKGAHPNRQSIGYTFPVPDGSSTQNLRPGEAIEGEVEMEMEETVAFGGIIGPDDSISSGEDTMNSELREKTMTFTFNHSVVRPQEDEEDDGMEMTIAQGGIINLPPPSPYPASPGRSLAYPPVSPGKTLPTNTRPMSGTPSFARHTLSSSQRSKDRESMLTSQKRNVFAPSPSPTKSTTPKKAGMQVAGEVAKRLSFGSASHPDSAILKRTREEEDSPSKGESKKGRSNAGMENNVEEVFGGTPKSEPPAKGRTSLFGSGSRLSLNAPRASLGTPMRIARSPASLRQSSVRVADPEPEPEPELEPEVEEQEWEQPQNISLAAFLEMTGVQFMEGLPGLNRRRSSVGKGILGQSYSGGERDFALHEYAEAQVNSIFLNMYTWAANKLREDIRTGQSELDLFESRCDEDSPPVIQEYLSATDEDKQLFEMTFKSFKTNTQLKAKEMWYDWKLQLMQTIKPDVEGMLEGMQEDNDRLTALREQTDSILPDLKARQAALQAELEKERQIVAEIAECDQQELASLKEGIAEQGAQINIFGSELEESTTKLAALSSKLEELNSTKRECVNAIQHAKSQCDQFTKSDAIRLREEYNSIQHLHLWRPIKIHANLLELEFDNEISLTFNCSNYIVNLWSAQITYLYDKAQQNKNGPIVKPNSQTPTQGLFAMLEIAIREMVKAKTFDTLSSFVQRIGQLWSVSQRIRAELHYVNFRYPIKYNLNDSNYLLASISIILNNSKSNLNIKSKILINFKITQETIWEYPENLNQTDIEILKIYGKADVNLLNSIAKETISSSTPQGCLGTFLQVCLNVSEQYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HTT0</accession>
    <name>A0A1B9HTT0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spp2/MOS2 G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_07533</name>
        <name evidence="7" type="ORF">I206_106576</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894016">
        <property type="protein sequence ID" value="OCF46678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007897.1">
        <property type="nucleotide sequence ID" value="XM_019159225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HTT0"/>
    <dbReference type="STRING" id="1296096.A0A1B9HTT0"/>
    <dbReference type="GeneID" id="30175902"/>
    <dbReference type="KEGG" id="kpin:30175902"/>
    <dbReference type="OrthoDB" id="5577072at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Spp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026822">
        <property type="entry name" value="Spp2/MOS2_G-patch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15818">
        <property type="entry name" value="G PATCH AND KOW-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15818:SF2">
        <property type="entry name" value="G-PATCH DOMAIN AND KOW MOTIFS-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12656">
        <property type="entry name" value="G-patch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spp2/MOS2 G-patch" evidence="5">
        <location>
            <begin position="235"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="261"/>
            <end position="469"/>
        </location>
    </feature>
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        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
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        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
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            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="330"/>
            <end position="340"/>
        </location>
    </feature>
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        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="405"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCF46678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC72614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="469" mass="53783" checksum="3B7A715A886B42A3" modified="2016-11-02" version="1">MTQPISFTVRPPTSAPHRPSPLGNGGSRGAPSRRLFELNGHDEDEDEDEDHQSSSRSRSNRPKEERIDGYRNGKALGGEKPAGPLVIPSLPNRDWRASSSRTPSYRPETRDLNEVIETHERTGDGPQRSGLRKKNDPTNYNDPYDKIKQEPSDSTISITEAVKQEYVEEDIKPIISQESEDVKKQTLEEQALQAILSGDVKVESDEERLRRELIIVGSNALSEEEALKRDIDELPEVSTAEDYAAIPVSAFGEAMARGMGWNPKSNDGTKIHEPKLRPALLGLGATALEKPLPPSRNGSSSGSNKKPKINKKDSMRINLGESIIKRESSEIPSSSGTNTRESSRRASPESDFSSSSKRRRDQDEHRDRDGKRYETEEERARRKARARERGREYETEEERARRKAKEKERNFETDEERAKRKAKEREGREKYDGDRERERSDKYDRDRRDDRDRDRRDRHDRDGDRRRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HUA3</accession>
    <name>A0A1B9HUA3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcription initiation factor TFIID subunit 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_07230</name>
        <name evidence="10" type="ORF">I206_106426</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894015">
        <property type="protein sequence ID" value="OCF46843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008062.1">
        <property type="nucleotide sequence ID" value="XM_019158924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HUA3"/>
    <dbReference type="STRING" id="1296096.A0A1B9HUA3"/>
    <dbReference type="GeneID" id="30175599"/>
    <dbReference type="KEGG" id="kpin:30175599"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08047">
        <property type="entry name" value="TAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037817">
        <property type="entry name" value="TAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006751">
        <property type="entry name" value="TAFII55_prot_cons_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228:SF0">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID 55 KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04658">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01370">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII55 protein conserved region" evidence="8">
        <location>
            <begin position="163"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="53"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="362"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="424"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="527"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="692"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="381"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="430"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="443"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="543"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="556"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="589"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="706"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="757"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCF46843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC72464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="768" mass="84763" checksum="8B2F9C598663C03D" modified="2016-11-02" version="1">MDYDSSSQAGPSTYNATPFSASSDALYSVDHSSALPTIGESVTYSAAGSANGYLHTNDIPTSGRGSRGRGRGRGRGRGSRGGRGSRGSRGGGGGGGGMRSSTRISERTVAEGERASQIKTKLKLSFNKLSKGNTGESSNGRFNSFLGEYDRELDENPDDPINFEEHFILRVPKDIAEGNAKHGIPIGLKEMIKGKGKDLENVEFKFLDSRRAAFKFNNNIYSAKLVDLPNIIESQKTFDNRHLFKIGDISQMLVIDPSAKPLKDENEIISIPLKIDEYIWPHGITPPMRHVRKRRFRKRLSRRAIEVVEEQVEDLLKKDAESEEHNYDLIDMHPDPEIADQYYIDYDPNATQWYNQESGSEFGYGEGAYDDPGSVTASQMEDWEGDYGTDMGEEGEGDDGEDDGEDGEEDGTLDQELAAALMEEMEGSDGSEHSVDEDRSGSEDDDEDDGDKSEEDDETIEKRAKIKQFTNEIKALEAAIEKKRAGFVGGNPIMMKRFEETISGLQADVQAKIASRQILQDDLGKNEDTLQFSNGTAAGEGGINKDVDMENHDADAEVEEDEVDNEGDGEGSTPMAKRTDERGSSIPYSDEDDLFGDDDDDVDEDNQQDGEGDVDEEGQEDMNENDENDLEQVEVDEMEDEMSRLLAAELDTLDQNTLNQIPKTPDAQAAELEYDQNTQDLLNNQVASNALNDLSDSNFDQDQDQIDNNNNDNDDFTQFNFDLNNNQNQNQPQPNGGFIEGGVGRRRLASGIGQDEVSSDDSSDESDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HUE1</accession>
    <name>A0A1B9HUE1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L29</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_07269</name>
        <name evidence="5" type="ORF">I206_106464</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894015">
        <property type="protein sequence ID" value="OCF46882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008101.1">
        <property type="nucleotide sequence ID" value="XM_019158963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HUE1"/>
    <dbReference type="STRING" id="1296096.A0A1B9HUE1"/>
    <dbReference type="GeneID" id="30175638"/>
    <dbReference type="KEGG" id="kpin:30175638"/>
    <dbReference type="OrthoDB" id="528635at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00427">
        <property type="entry name" value="Ribosomal_L29_HIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.310:FF:000002">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3450:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_uL29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_uL29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018254">
        <property type="entry name" value="Ribosomal_uL29_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045059">
        <property type="entry name" value="Ribosomal_uL29_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_uL29_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="Ribosomal protein L29 (L29p)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00579">
        <property type="entry name" value="RIBOSOMAL_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF46882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC72502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="127" mass="14739" checksum="A1B9E0AC222E8726" modified="2016-11-02" version="1">MASSSSKIRAFELQSKSKQDLLTQLNELKTELASLRVQKIAGGSASKLTKINTVRKSIARVLTVINHKQRDNLREFYNKSKYLPLDLRYKKTRAIRRRLTHKESHAITEKQHKKNIHFPARKFALKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HV61</accession>
    <name>A0A1B9HV61_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sulfatase-modifying factor enzyme domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_06938</name>
        <name evidence="7" type="ORF">I206_101971</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="OCF47160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC68052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008379.1">
        <property type="nucleotide sequence ID" value="XM_019158633.1"/>
    </dbReference>
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    <dbReference type="STRING" id="1296096.A0A1B9HV61"/>
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        <property type="component" value="Chromosome 2"/>
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        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:methylation"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="paralog of FGE (formylglycine-generating enzyme)"/>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
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        <property type="entry name" value="CTDL_fold"/>
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        <property type="entry name" value="EgtD_Methyltrsf_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019257">
        <property type="entry name" value="MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397:SF1">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10017">
        <property type="entry name" value="Methyltransf_33"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine-specific methyltransferase SAM-dependent" evidence="5">
        <location>
            <begin position="60"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine-specific methyltransferase SAM-dependent" evidence="5">
        <location>
            <begin position="178"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine-specific methyltransferase SAM-dependent" evidence="5">
        <location>
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            <end position="560"/>
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    </feature>
    <feature type="domain" description="Sulfatase-modifying factor enzyme-like" evidence="4">
        <location>
            <begin position="784"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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            <end position="318"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="3">
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            <end position="123"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
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            <end position="313"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="337"/>
            <end position="370"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10017"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC68052.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HVT1</accession>
    <name>A0A1B9HVT1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lipid particle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_06267</name>
        <name evidence="7" type="ORF">I206_101762</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC67845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008590.1">
        <property type="nucleotide sequence ID" value="XM_019157977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HVT1"/>
    <dbReference type="GeneID" id="30174636"/>
    <dbReference type="KEGG" id="kpin:30174636"/>
    <dbReference type="OrthoDB" id="273452at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF62">
        <property type="entry name" value="LIPASE ROG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628204" evidence="4">
        <location>
            <begin position="25"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="DUF676" evidence="5">
        <location>
            <begin position="3"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="DUF676" evidence="5">
        <location>
            <begin position="78"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="35"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCF47371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC67845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="492" mass="55527" checksum="DD9EECA672B5DF9A" modified="2016-11-02" version="1">MAERVHLVVLIHGLWGSPAHLAVAKEELEKAWSGQKLSQDVSGPPEDPTIITELSSPLSPSNGNDSKTKGSNPEDGQLVIMIAGGMTSQLTYDGIDVCASRVAYEIDLKIRELEKEGKNVDKFSVMGYSLGGLVARYLVGLLHSRQPSFFDKHRPISFSTISTPHYGIPKYNTLLSRVLTYLGARVMSRSGEQLYVADNYSDEDQRPLLEIMANPRGIFYQGLEKFTRLEIYASAVNDHTVPYPSAAIEPIDHFVQWEERGMSVDSDEDGIIQSWSIREEDRTEKPKNSNKKGFGFKIGTLPPVLRYKFPFNYIILLLLPIMLPLMIILILTRQSLDTRRSKHRLQILSQTSKSSEISYHIPHSGGLSIQALREGIRRIERSLESDLVENVNVEIGIDSPSIFKSSILNDNHNSYKNEESDLKVELKDSQLRMCLWLNQLPTKKILTWWPEINNAHATAIVRDPKQFPAHERGRGLIKLWARNTLNAAKTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HW66</accession>
    <name>A0A1B9HW66_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_06415</name>
        <name evidence="3" type="ORF">I206_101615</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008733.1">
        <property type="nucleotide sequence ID" value="XM_019158120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HW66"/>
    <dbReference type="GeneID" id="30174784"/>
    <dbReference type="KEGG" id="kpin:30174784"/>
    <dbReference type="OrthoDB" id="10670512at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="759"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="708"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="772"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="807"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="831"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF47514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC67703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="949" mass="103885" checksum="602BB641283263EC" modified="2016-11-02" version="1">MEAQPLSLPSTGKLPASIVPSSSETPSNGTIFVPDLIQLLAQSYPGLTPTSSDLPNDLVISSDHLVIKWWDLPPGYTTGSWAEWEPEAPYKPSPDEPLVAYEQKDVDDLLDRMVEEREEQNAEEKTWEDRYEIQTPADQSFDVQLEESTVASSRNDISPTTSPPHSLSSTHLMIERPFSDQNHNQDHLDSPRDQAAYKPFEAKKNITPTINGYPKAGDDSAQNPPIGVDIISHNQPEISFNSSPSPPLNPIQDQIMPYEAIEEVKDTQLVMETELSSNHSLSDSDGLKTPSSSGFQTPKWKCHASSIVKSHEHSPQTPSNRVILVDTSHISVCHGAFRQACTSIFHPDNSFGPSALADRSRVLQRSATCPAVSTTVTKTDQEACPQSSAGQVRAVIPTHPDDSMCSTARTSLSAPQPFLAEQQVTEESPEFEMAQPDDSPLLDEFSRLHLAPRNPPAIEGISTDLSTESNAPHPRSSQDSRPSPELSVLTTPMTSHNGNAALPLSPLPDNVTTVLSESFSAEVSNSSTLDHNMSKDHKGEVHRLMVSQRDGQPDLFDFDEDSSKIPEAQQSSEGVIVQTITCTTDRAEPGVRGQFEAEGEQIGEYTPQAEEDTGNGGFTVEGHQGVPESEEETCVGNKSKSSQDSYTSTAERTLKGRSKRKVATQDETAAPKPKRRYTRRTEKNETGAVKPEQKSAASQDIDGISHAVPKKRGRPSHKHLIQQQVTEHTAALSSAGPSRSTKSTSVAPAAYSVGANYGQPLQAKPHAKSHPNRQITSSALQAANTKAVRSYWVTRESDEKAQDDDCSSSNPTSAPQFTRAMPQPPERESARQANRALQNCTASARTHRRSISTISSTEDPLLLTPTVSAASASSPTSEINGSKLIMRGQITPYGKHRRWEAEEDAIILKVYEQYEDTDMDRLQMSTLMEKNLKKLNFEIQRTSGSIKWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HW95</accession>
    <name>A0A1B9HW95_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable electron transfer flavoprotein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I206_06448</name>
        <name evidence="15" type="ORF">I206_101582</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11 12">Binds 1 FAD per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008765.1">
        <property type="nucleotide sequence ID" value="XM_019158152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HW95"/>
    <dbReference type="STRING" id="1296096.A0A1B9HW95"/>
    <dbReference type="GeneID" id="30174817"/>
    <dbReference type="KEGG" id="kpin:30174817"/>
    <dbReference type="OrthoDB" id="1715808at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000001">
        <property type="entry name" value="Electron transfer flavoprotein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018206">
        <property type="entry name" value="ETF_asu_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153:SF1">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00696">
        <property type="entry name" value="ETF_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 11 12" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="13">
        <location>
            <begin position="25"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="257"/>
            <end position="258"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="271"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="288"/>
            <end position="295"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000089-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCF47546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WWC67671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="344" mass="35558" checksum="1FEFBAEE0E27F6B6" modified="2016-11-02" version="1">MLVRAAIRSSRSSSLATAQRRLASSLVFLEHKNGKLNDSSLNAVTAAQTLGSDTAGIVVGSKSDVDSVLEEVKKIDGLTKIYTAASDDYAHTLAENVAPLLASVLPAKNISHLFAAHTAVGKNVFPRLAGILDSSMIADIVALESSGDVFTRPIYAGNAILKIKSSPKDAIKIVTVRTTAFDKAKTGGGNASVEEVEAKSGDSSTKYVSEELTISSRPDLSSASRVVSGGRALKSQENFNKILDPLADALGAAVGASRAAVDAGYADNSLQVGQTGKVVAPELYVAAGISGAIQHLAGMKESKLIVAINKDADAPIFQVADVGLVADLFEAVPELTKKIEGAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HWN8</accession>
    <name>A0A1B9HWN8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exoribonuclease phosphorolytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_06563</name>
        <name evidence="8" type="ORF">I206_101465</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008877.1">
        <property type="nucleotide sequence ID" value="XM_019158264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HWN8"/>
    <dbReference type="STRING" id="1296096.A0A1B9HWN8"/>
    <dbReference type="GeneID" id="30174932"/>
    <dbReference type="KEGG" id="kpin:30174932"/>
    <dbReference type="OrthoDB" id="27298at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0271">Exosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="6">
        <location>
            <begin position="17"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCF47658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC67556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="313" mass="34975" checksum="B0010BACDA07E2AF" modified="2016-11-02" version="1">MSNAGPSRRYDGRRYDQYRPLQIEIGELDRADGSGRFGFGSTAALASCSGPLEVRLNKELPTRATLEISHRPLEGVGATPSRALVTTLESIFPTVLSLSSYPRSLIQLIVQSLSSSSTTLNSSTSSNYNPDIYIDIEPDNNEKNVWPQFGNKIKFEDDKSPNTSYPFSIRSTSINSITLACLDNSSIKMINLPISISISYLINKGLIIDPTIQEENQSSSRFGFAWSFGKNIKVNVKKSISKQDLKNKMDIEGEEDDNNNDQVEMELVWVESEGKFTKEIFSDALELSKIACRKILDEIRSKLGEKLENRKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HWW9</accession>
    <name>A0A1B9HWW9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_06672</name>
        <name evidence="5" type="ORF">I206_101359</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008984.1">
        <property type="nucleotide sequence ID" value="XM_019158371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HWW9"/>
    <dbReference type="STRING" id="1296096.A0A1B9HWW9"/>
    <dbReference type="GeneID" id="30175041"/>
    <dbReference type="KEGG" id="kpin:30175041"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF26">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="301"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="634"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="709"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="250"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="273"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="637"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="709"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="719"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="742"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="756"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="775"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF47765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC67451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="833" mass="92024" checksum="E34AD42561586125" modified="2016-11-02" version="1">MSTKQLPKGEQPLPLKHLLKNFTSDYPLRAPSPIPPSSRVDPNLKQKLPPSSSSLNIFLWTIPTWWLFLRFLITKGLTIYFNLLNHFLFGPKRKSWGYRMTFITSFMRNISDHSSLADIILIRKLISLHFLLPLPSNAIVTPITFKVPSYSSSSSSFSKNFKRKKENSINPSTSTTSKSIGLLEYLDLKENGQRELSGEWVVCTDVWKRLKSERRLRNRIKLKKSSTSSKSKHSGLINSLTPTLEEKLSSKSTNGSYNSPTKYDLRPSPSPQRTNRSNSTHSTTTPTTDSESDKTGERVIYYVHGGAYYVGNAATHRLVTIGVSQSCNARVFAITYRLAPEHVFPLPLHDVLHGYLRLLAPPLSIPPENIIIAGDSAGGGLSLALCMYLRDEGYKLPAGLVLMSPWVDLTMSCGSWDENAATDVVPRPEADDHLNPVGCYLGPEGISRYLTHPYASPLFGDLSGLPPMLIQSGDSEVLRDEITLLAHKATLAGVHVTHELYEDMVHVFQMFSFLPAATAAINNVGKWVCQTLPAIEEEEVMGKLNKEVEEEMETSPRVVSGDGEELNVTNQSNQTQIIPDEIDAVQDYRASRLRTPKASALSLDIGEIQAQPEILNQDTTVDLDSLSYDPHMSEINSTIAGSSSRSRSRSITPTPKSRRTAALDSSLDLSGVPSFSQSNNSFNAPYTLPRLRRSYTNVPFSHHTILPLSPTPTSTSSSNYFSHNDNVDNGTTTGRRRRRTTYSLHVSPAQSTGIRTPSNPTSPTPSIRKRLRGMSISNSNNGTPSTRARSKSHSDIFQLVEGYVECGAANTTTIIDPEGEVKSMGVLGENEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HX64</accession>
    <name>A0A1B9HX64_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_05708</name>
        <name evidence="7" type="ORF">I206_107382</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="KI894014">
        <property type="protein sequence ID" value="OCF47848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009067.1">
        <property type="nucleotide sequence ID" value="XM_019157427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HX64"/>
    <dbReference type="STRING" id="1296096.A0A1B9HX64"/>
    <dbReference type="GeneID" id="30174077"/>
    <dbReference type="KEGG" id="kpin:30174077"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000025">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase CYP19-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="9"/>
            <end position="166"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HXA6</accession>
    <name>A0A1B9HXA6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Respiratory supercomplex factor 1, mitochondrial</fullName>
        </recommendedName>
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    <gene>
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        <name evidence="2" type="ORF">I206_107437</name>
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        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
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    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019157479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HXA6"/>
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    <dbReference type="KEGG" id="kpin:30174133"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC73467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="15429" checksum="A906A44B2D62952F" modified="2016-11-02" version="1">MPHSATLQEKQRREEHQQRAYEIQLAGGLQGAARWTVYGTIACAMGHFAYPPFARQTLGLKAFLVSSATIFGLVVGADNHLLKYESHLREAENDIRRQARAELALEGRIASETEIRKWREANKEKLAIQAEIAARGAT</sequence>
</entry>
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    <accession>A0A1B9HXB4</accession>
    <name>A0A1B9HXB4_9TREE</name>
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            <fullName evidence="8">Copper chaperone</fullName>
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        <name evidence="8" type="ORF">I206_05779</name>
        <name evidence="9" type="ORF">I206_107450</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
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        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">CBS 10737</strain>
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    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ATX1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="OCF47915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC73480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1296096.A0A1B9HXB4"/>
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        <property type="component" value="Chromosome 11"/>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051881">
        <property type="entry name" value="Copper_transport_ATOX1-like"/>
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    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
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    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365:SF1">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0187">Copper transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF47915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC73480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="102" mass="11037" checksum="A8470AA1E5954C27" modified="2016-11-02" version="1">MATPANLNVINSNPNSKPTVPAYQYNVKMTCTGCSGAVNRVLGKNIQPPNAYHISLPTQTVLVWGPNLPSFEEITQKISKTGKTINSQQLIDDATKIPSIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HXF8</accession>
    <name>A0A1B9HXF8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWI/SNF and RSC complexes subunit Ssr4 C-terminal domain-containing protein</fullName>
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    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_05817</name>
        <name evidence="5" type="ORF">I206_107489</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="Mohammad A.W."/>
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                <person name="Litvintseva A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
                <person name="Chen Y."/>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC73292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009638.1">
        <property type="nucleotide sequence ID" value="XM_019156920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HYQ2"/>
    <dbReference type="STRING" id="1296096.A0A1B9HYQ2"/>
    <dbReference type="GeneID" id="30173566"/>
    <dbReference type="KEGG" id="kpin:30173566"/>
    <dbReference type="OrthoDB" id="2240312at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000500">
        <property type="term" value="C:RNA polymerase I upstream activating factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000182">
        <property type="term" value="F:rDNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039601">
        <property type="entry name" value="Rrn5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28079">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28079:SF1">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="723"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF48419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC73292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="796" mass="91918" checksum="56EF1A1933B3304A" modified="2016-11-02" version="1">MTQSARSLEAEIPNESSSKWYINHLDAHITASKRQILGQTSILNPNKRSAYPTIVPPSNALWTPEEKEIFFASLRRHSRYRPDLISAQVGTKNEDEVDWYLDLLEYGAEITGQVDHNRRHEYPEPKIRYDGLRSWRKGLAPSARETSDRWIEIEEVLAKSVIKDIQQREEDELSIITKRNRRVEKRELAQKLEFIQDEDKLTPYKREKLFEEHPSYKGMENKWAIDDYLKEIDGVKLSELNGLMKPDWSTWYSDRIKPIKSFNYKPPPLDGENNNRYASPQERAEAEEADLETNAIAPKRVDPQGKIEMDQQNYLEIMAIPKKERTNEQRKLLTAITNRRRNREKYRIQKLMEEGMTKDEIDSAGGADAIFAGREKGDTAIAQPVSRRIKAKPESSAMVGKLRRMGMYDHLMMSGVEVFNFDMIRKVYKEQNPDRPSNISFSVLQGIHKLLVNELRRLIYHTLFVAEQAYLQRPGSEDDQAPEVEASHVHQVLLTLGLNHPGVTIIDFLERIFDEEGGDEQDREGTPRASDDDQDEDEGSEGSCDREDGTEEEKVSLRTHQFESSIFPPGEIPWHHLPHFDPDLNDQSTEDTEESYQVDEMSDAATELEGKELDDALVKLDEAHDATYERSLWKHVKKDTKGLDGDDRAEIWTMKYDGAKNDKSDQHLAEKGYISLLLSSDVARRKRKYIELIHCRYPTTRIKTLARANKRLKSNAWIIDSDSETEDEGGYVWNPNQEEREDYDSDISESDEGSQVSNDEDALDDEEQDELEDEKGDDAVDEDDGEFETEKGDPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HYT8</accession>
    <name>A0A1B9HYT8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_05208</name>
        <name evidence="12" type="ORF">I206_107247</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC73281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009649.1">
        <property type="nucleotide sequence ID" value="XM_019156931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HYT8"/>
    <dbReference type="STRING" id="1296096.A0A1B9HYT8"/>
    <dbReference type="GeneID" id="30173577"/>
    <dbReference type="KEGG" id="kpin:30173577"/>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05312">
        <property type="entry name" value="NAD_bind_1_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10380:FF:000009">
        <property type="entry name" value="NAD-dependent malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000182">
        <property type="entry name" value="NAD-dependent malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF34">
        <property type="entry name" value="NAD-DEPENDENT MALIC ENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="10">
        <location>
            <begin position="110"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="9">
        <location>
            <begin position="315"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="512"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCF48430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC73281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="623" mass="68266" checksum="80E89C3450C56AA0" modified="2016-11-02" version="1">MIRGSSSKIARTRVNASSRIATRGMADRPIIAANKNFVPIRTNLRGSALLNTPRLNKGAGFSREERQIFGLEGFLPYDVHSLEKQALRAYNQLLKQPSVILKHAFLASLRDQNQVLFYKIMQDHLKELLGVLYTPGAAEAVANYSNLFRRPVGCYISFPNQDGMRAQLEGHLLDVNRTADVAYDSNNPHDAIDLVVVTDAEAILGIGDQGVGGITISTSKAALYTLGAGINPNRILPVVLDCGTDNHALFSDSLYMGWKRTRIRGKNYDQFVDRFIQNCRELYPNAIIHFEDFGMANAYRLMEKYKNIPMFNDDIQGTGAVALAALIAAIKVSGARLSDQRIVIYGAGSAGMGIADQIKDGLMILEGLSEEEASRRFWCVDRNGLLVESMGNNLRHAQLPYARPDSEVEEWAKSEGDNDGVWLMDVVKNVKPTVLIGTSTHSRAFSEELIREMGKHVERPIIFPMSNPTALCEVDPADALQWTENRALVATGSPFPPVELGNGKQYTVAQTNNALIYPALGLGSILARSKTISNSMLMAGVNSLASLSPALTNPEASLLPDLADVRNVSVEVAAAVCRQAVSDGNAQDLNTIKVVQGKGSLTLEEYIRSRMWDAVYRPLELVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HZ21</accession>
    <name>A0A1B9HZ21_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_05260</name>
        <name evidence="3" type="ORF">I206_107195</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC73229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009700.1">
        <property type="nucleotide sequence ID" value="XM_019156982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HZ21"/>
    <dbReference type="GeneID" id="30173629"/>
    <dbReference type="KEGG" id="kpin:30173629"/>
    <dbReference type="OrthoDB" id="3178019at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="544"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF48481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC73229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="687" mass="74546" checksum="39BDDB187C6637A1" modified="2016-11-02" version="1">MPRFHPPLSHSSTIHIDSTHPYIQLNFFAVFAEGEDLSGSWQIWSDLPQLDEHGATISRPGEWTATDFRSFLPSIPKVDESQHINGSLSNTAIHVRSRTDIHITSSGPPTLFASIIIPATDGARYSYTYRHITPSNEIHWLGGVGGNGIIRMTEGERVNDTKDGSTGIWSEVYANLANKTWAGFALSFQPFNGSTKPLIHELPADSDIAASLALLTTEPLVHQTIPFDQPTRSSSIIPPSTSMTVLAVLANHSGLHIGGGSPLPEESDKAVYSDTTGSFVRALAAALRAPGMGKQPFDLSTIAPPHQNTAALLTHHDGRSGQAHLVVFALNLASPQEIKIALADFDQAPLAAISDAHHSIIYIPECADSSDRELALRWDKGLVAEVIQLSAFTQLRGAGKDDPIWICAPDAASVEIGEEEICQAHPARQASLTSVHNDISPKATLGAEDEDDDPSGHPEPSEAIPEDEAASEAEGGSSLERPNTSDRPQGPWWLFRFIGRFFVNIWQFLFSPFRSRPAITSGTDEVQDAANEESPSERTPLLGSHSMSRDTSSSSTAVDPLATPASLAVHKDQTQHDELQNGLITPVGNSATSEFPFQPPVLNAVQIRSYAQMSFKNLPPFRFLLPPNPGDVAANLRFLVKEKAGQKWERVEPELQSPVEDGRCQEMMVQSINGTGGTDWEVQIERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HZL2</accession>
    <name>A0A1B9HZL2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Translin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_05480</name>
        <name evidence="8" type="ORF">I206_106977</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the translin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC73012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009919.1">
        <property type="nucleotide sequence ID" value="XM_019157201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HZL2"/>
    <dbReference type="STRING" id="1296096.A0A1B9HZL2"/>
    <dbReference type="GeneID" id="30173849"/>
    <dbReference type="KEGG" id="kpin:30173849"/>
    <dbReference type="OrthoDB" id="31005at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14820">
        <property type="entry name" value="TRAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.200:FF:000001">
        <property type="entry name" value="Translin-associated factor X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.190">
        <property type="entry name" value="Translin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.200">
        <property type="entry name" value="Translin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016069">
        <property type="entry name" value="Translin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016068">
        <property type="entry name" value="Translin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCF48700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC73012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="32064" checksum="68984F7E84081211" modified="2016-11-02" version="1">MADVDILMPSEAGSSSSSLSRKQHLMNTFESYRSELDTDNERRERLIITSRSITQLSKKLIFHLHRNATSLSPSLKEKCLKEGRGKEREIWKLFNKIRDELDSIGNGGDSEAKEAYWRWNRQVSPGLEEYIEGLSFLYYLEHKSLVPLEEVQRTLSDENGQSLVVVTPEDYILGMSDLTGELMRYATNALSTGDHNTPLEVCDFVRTVKSHFDGIPPHMLYKLSKKQEETTRSLEKIERVCYALRLRLIEFADKPEVLAMMAKRALEDAAEKDERGKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HZT1</accession>
    <name>A0A1B9HZT1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Actin-related protein 2/3 complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_05551</name>
        <name evidence="11" type="ORF">I206_106904</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
            <location evidence="7">Cytoskeleton</location>
            <location evidence="7">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the WD repeat ARPC1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="OCF48770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC72940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009989.1">
        <property type="nucleotide sequence ID" value="XM_019157271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HZT1"/>
    <dbReference type="STRING" id="1296096.A0A1B9HZT1"/>
    <dbReference type="GeneID" id="30173920"/>
    <dbReference type="KEGG" id="kpin:30173920"/>
    <dbReference type="OrthoDB" id="406844at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017383">
        <property type="entry name" value="ARPC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709:SF2">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038093">
        <property type="entry name" value="ARP2/3_su1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="51"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="333"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF48770.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC72940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="411" mass="43965" checksum="DFE7E93A964A21EC" modified="2016-11-02" version="1">MSAPEVFQLSLGPLTGIAFSPDRSQVCVCPNSNEARIYTRNGDSWDLTDTLAEHDKLITAIAWGPNTNRIVTCSQDRNAYVWTQTEQGWKPALVILKINRAATSVKWSPAENKFAVGSGSRVIAICSFDEENNWWTARQIKKPLRSTVLSLDWHPNNYLVAAGTADGKVYVYSGYIKGLEAKPEANIWGDKLPTGHLLAEFRSPNGGWVHDVAFSPSGDALAFVAHDSSINIIYASGPNEPPAAHIVVKLPSLPFTSLTWTSESSIVAAGHDCQPILFSGSHEGWAISRSLDDPSSTAKPLTPTATGARAGGVGRLGNNEAFNMFKAADSKGQRGTPQPGATPTSAGLTPVGSDGLLLTVHQNTITHVEAYEWNQSGEVSKIFTAGRDGRLVVWSVTGGKGLTGRMAGLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I091</accession>
    <name>A0A1B9I091_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PARP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_04637</name>
        <name evidence="3" type="ORF">I206_105817</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF48950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC71858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010169.1">
        <property type="nucleotide sequence ID" value="XM_019156367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I091"/>
    <dbReference type="GeneID" id="30173006"/>
    <dbReference type="KEGG" id="kpin:30173006"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF48950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC71858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="103" mass="11524" checksum="6872782D810B6986" modified="2016-11-02" version="1">MGGFGSSTVGSDAGNGETISNSIPWQYIIPAIVPGLLILLFICLRCGLPRLKKRIFARVCAKPDCKFGRYIEQKDRTKAKQDKTNGGLDTWYHKECFKENENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I0E8</accession>
    <name>A0A1B9I0E8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_04697</name>
        <name evidence="7" type="ORF">I206_105877</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </source>
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    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="7">CBS 10737</strain>
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            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
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                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
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                <person name="Griggs A."/>
                <person name="Gujja S."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1">CBS 10737</strain>
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    <reference evidence="2" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="1">CBS 10737</strain>
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    <reference evidence="2" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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        </source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
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    <name>A0A1B9I0Q7_9TREE</name>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">CBS 10737</strain>
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    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
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            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
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    <comment type="similarity">
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        <property type="molecule type" value="Genomic_DNA"/>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I101</accession>
    <name>A0A1B9I101_9TREE</name>
    <protein>
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    </protein>
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    </gene>
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        <lineage>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
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    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
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                <person name="Imamovic A."/>
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                <person name="McCowan C."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="7">CBS 10737</strain>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="OCF49138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="entry name" value="RRM_euk-type"/>
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    <dbReference type="PANTHER" id="PTHR48034">
        <property type="entry name" value="TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED"/>
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    <dbReference type="Pfam" id="PF00076">
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        <location>
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        <source>
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        <source>
            <dbReference type="EMBL" id="OCF49138.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC72043.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1B9I153_9TREE</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
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    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
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                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010476.1">
        <property type="nucleotide sequence ID" value="XM_019156674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I153"/>
    <dbReference type="STRING" id="1296096.A0A1B9I153"/>
    <dbReference type="GeneID" id="30173314"/>
    <dbReference type="KEGG" id="kpin:30173314"/>
    <dbReference type="OrthoDB" id="10264196at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06822">
        <property type="entry name" value="PLPDE_III_YBL036c_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000007">
        <property type="entry name" value="Pyridoxal phosphate homeostasis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00044">
        <property type="entry name" value="YggS family pyridoxal phosphate-dependent enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PROLINE SYNTHETASE CO-TRANSCRIBED BACTERIAL HOMOLOG PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146:SF14">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE HOMEOSTASIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine racemase N-terminal" evidence="6">
        <location>
            <begin position="23"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2 3">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCF49257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC72161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="268" mass="29038" checksum="F3D3185D6D76B28E" modified="2016-11-02" version="1">MSTSMSLEYTSDRAEELKENIESVQAEIDQAVSASGSKPRLVAISKIKPASDIKALYDAGYRHFGENYIQEMVDKAEVLPKDINWHFVGALQSNKSKLAASVSNLHVLETLSSIKVADLLQKSLSPSRTSKLNVYIQINTSAEDAKSGLPSLSSTSSDGEVVDLAIHVIRNCPGLNLLGLMTIGSFESSHDSSKPNPDFTTLKETRKELARILREKGIEGAPEENQLELSMGMSADFAQAVKEGSSSVRVGTRIFGERAKKVPKAAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I185</accession>
    <name>A0A1B9I185_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">A to I editase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_04993</name>
        <name evidence="3" type="ORF">I206_106168</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010522.1">
        <property type="nucleotide sequence ID" value="XM_019156720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I185"/>
    <dbReference type="STRING" id="1296096.A0A1B9I185"/>
    <dbReference type="GeneID" id="30173362"/>
    <dbReference type="KEGG" id="kpin:30173362"/>
    <dbReference type="OrthoDB" id="10268011at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003726">
        <property type="term" value="F:double-stranded RNA adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008251">
        <property type="term" value="F:tRNA-specific adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006382">
        <property type="term" value="P:adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002466">
        <property type="entry name" value="A_deamin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10910:SF62">
        <property type="entry name" value="AT07585P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10910">
        <property type="entry name" value="EUKARYOTE SPECIFIC DSRNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02137">
        <property type="entry name" value="A_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00552">
        <property type="entry name" value="ADEAMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50141">
        <property type="entry name" value="A_DEAMIN_EDITASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A to I editase" evidence="1">
        <location>
            <begin position="58"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF49303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC72207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="474" mass="52483" checksum="764B3EA5D9DA2167" modified="2016-11-02" version="1">MEALRDAIVNSAHQLYASLPAHGKPVVRSNGTPEWTILSTISLVDCSNPSTESIIPISLGTGVKCLPYTKLSKYGDTLHDCHAEILARRGLMRWLLYQAQLYTRSRSCSDEEGTDETVYLELVNGRFRLKGNLQLWLYISMLPCGDASTFYTSSHQSVEEASQWKEADSRSINQADIHISRGRNGYTALSTLRTKPGRPDSIPSISMSCSDKIASWSILGIQGGLLSNIFEPIYLDGIIVGGLDTPSSVNEVEWREKIKREMERSIWGRLESIKDHIPDPYVLHRPAVHFSSNSFEHSKSTLAKTPTVDSLETSPSPLSISHLPFMPASTTRKGVKPEIIADGGALGHPWKKGKLIKEKGRSRICKLALLGEYERVIANLDPDQNYDLVKSQKTFYDYKHNHASKYQLVKSILRGIPKQGNTLKGLESFDEILSTGIADIPGSSLEYPAPIPPFKGWLVAGKPFESFTASGIIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I1K5</accession>
    <name>A0A1B9I1K5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aromatic amino acid aminotransferase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_05097</name>
        <name evidence="8" type="ORF">I206_106271</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010623.1">
        <property type="nucleotide sequence ID" value="XM_019156821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I1K5"/>
    <dbReference type="STRING" id="1296096.A0A1B9I1K5"/>
    <dbReference type="GeneID" id="30173466"/>
    <dbReference type="KEGG" id="kpin:30173466"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008793">
        <property type="term" value="F:aromatic-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009074">
        <property type="term" value="P:aromatic amino acid family catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF21">
        <property type="entry name" value="AROMATIC_AMINOADIPATE AMINOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="131"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCF49404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC72309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="477" mass="53249" checksum="5EF4CAEA4BB12E62" modified="2016-11-02" version="1">MPSIDPAPVKIDFTKYFSQESTGRKRSQLKELRPYFEIPGMISFGVGIPHPSTWPVNGMTLSVPFAGKSVYVPGYESRSPEDMLPLAPYSDPVKGDNLFPDLAGELQYSATYGTPHLLGWIKEHTQRIHAPPYEDWVNLCTAGNTDGVDAVMRAVFDRGDYMLVEEFAYPGLLSPAATLGIKCLGVPLDTDGLVPEALDEILTQWDEKERGGPRPKMLVLVPTCSNPAGVTIPVQRKREIYSICRKWDVLICEDDPYCFLQIRPNGADSPIVPSFLSLDTDGRVIRVDSFSKIVAPGSRLGWVTGHKTLVEKIMNTRESATQCPSGFSIAAIAAILRAWGSHEGFEKKYIPHISDIYSKRCLSMIDLLKKHVPAATVELPEPSGGMFLWIRLKIETHPSFPSEDPEVISKRVFQSMIDEKVLMAPSEFFKAPSISTWTKEEEAKRNFVRISFSLPPPEEMEEGCKRMGRALAKEWKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I1Q2</accession>
    <name>A0A1B9I1Q2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_03980</name>
        <name evidence="11" type="ORF">I206_104439</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010678.1">
        <property type="nucleotide sequence ID" value="XM_019155720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I1Q2"/>
    <dbReference type="STRING" id="1296096.A0A1B9I1Q2"/>
    <dbReference type="GeneID" id="30172349"/>
    <dbReference type="KEGG" id="kpin:30172349"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000013">
        <property type="entry name" value="Related to multidrug resistance proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF102">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="520"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="59"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF49459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC70488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="623" mass="67142" checksum="CDB2310DA5C550FA" modified="2016-11-02" version="1">MANKNGTNNDVERALPQNEVSAKDMVEKGDDNKNVKHTHGDWRAEEQEIEIPKNNLWIVMPTVGLVGFIAALDQSIVSTALPTIAAEFDTTPSQYSWIGTSYLLSQILMSPVNGRLTDIIGRKPALYMAVFFLLIFSALCGAAKSATWLIIARAFAGLGGGSVVSLSLIVVSDVVPLEKRGSYQGYMAAIWGVAGTLGPVLGGLLTTKASWRWCFYINIPICAIALILIFFFLNLKRTKRGDVAELRRSFDFVGLVLIMAASALIVVGFSNAADAGFDSKSAYGVIIGGVITTALTVAHCVTTKKNAIIPARLLRTRTPLFFTFGSFFLSLMFLPATFLLPQFFQGVGGATSLKSGVDFIPFCLGLIVFSILAGEISTRLHIVRPLIWTGFSISALGYGLWYALLTYDVPYATQEGIQVIVAAGIGLAISTPMLVIQASMPGKDMAASTAAWTLTRSIGACIGLAIFTAVFNTGLRSRFSKIEGYGTVFTVPTGTQGYHALHDLPEGELRNSVLNAFADSMRVCWIIGCALSCTALAITLCTKSYSLERTYATNTNTNEAETPANEKGNLDNGIQAETVDQDEPVTELDQATIDREERAMMRMEDGLRDTGGSMPPTRITSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I276</accession>
    <name>A0A1B9I276_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_04178</name>
        <name evidence="10" type="ORF">I206_104244</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010875.1">
        <property type="nucleotide sequence ID" value="XM_019155917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I276"/>
    <dbReference type="STRING" id="1296096.A0A1B9I276"/>
    <dbReference type="GeneID" id="30172547"/>
    <dbReference type="KEGG" id="kpin:30172547"/>
    <dbReference type="OrthoDB" id="2192946at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1900:FF:000011">
        <property type="entry name" value="Spindle pole body component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF13">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="179"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="565"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="54"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="77"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCF49656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC70294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="910" mass="101456" checksum="D8CF04AC53131599" modified="2016-11-02" version="1">MTSRIPSGSTVPFTPKPRKRTSSSRLSLNDREYNQFVGTLASVRRVKPNAILEELEQSGEGNALLARPDGPSRERGPSQPRPSSSRADRIPSTSSQPPRPSSSSSRHQERDSGRPSSSRSTPVAILPRPDIESSKRNGKLPERVAQLSLADGIDENDGSEERRNLDGVPLEIQEAWICEDLLFVLQGVEGSLIRYHEDYDPLDAEQASKGVKWRVDPSLDTSLLSLVERLLPLATCFTAVEASMESRNSPEYGMVSHALSSGIRAMLKEYRVLTAQLESLFLSSPTFTLQTLYFHLHPTLHTMSLLAGLCLALETDEVGQDNSDVSDDDDGLGGMAEELGLGGAGLKGLMKNLNAQDGLIGGGGPVLGGEVLGIICEREATMSGDPTASTLHSTLLLHASQPYFKMLVRWISTGYLLDPFDEFMVKESGHITKGVLESDYTDEYWERRYTLRDGSSLTSTKVGTGKSTSTIGAGVTVPRAGTNRLPGGACIPGFLQPWKHKILLAGKYLNVIKECGIEVKKPTEVQEEGDGMVAMNEPKFYKRIEDAYIYANKTLLKLMVEEQELIPHLRSMKHFFFLDQSDFLTNFLDLAATELRKPAKAASLVKLQSLLDLTVRNPASSSSNDPYKDDLKVVMQSQKLYDWLLKIVSKTGGLTEDGELDFAMGDGPDHEAQKSDKDKTVYAIDALAFDYSVKFPLSLVISRKTITRYQLIFRFLLHLHHLESALSSMWIEQKTSIWRTNTNDQDMEKWKYRVFSLRSRMLDFVRQVLAFATGEVLEPNWKILESKLHKVQTVDQLLKDHVDFLDTCLKQCMLTTSKLLSIYARLMRTISTFISYQSQLNIVISRFMADPEGESKPKQVAARWSSLQKFEAHFNHNTKLHLDAVTYNAGSENVALLALVTRLHQTTLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I299</accession>
    <name>A0A1B9I299_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chaperone activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_04166</name>
        <name evidence="6" type="ORF">I206_104258</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
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        <text evidence="1">Belongs to the AHA1 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="AHSA1-like_N"/>
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        <property type="entry name" value="ASHA1/2-like_C"/>
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        <property type="entry name" value="START-like_dom_sf"/>
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        <property type="entry name" value="HEAT SHOCK PROTEIN 90 HSP90 CO-CHAPERONE AHA-1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="LD43819P"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Bet v1-like"/>
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    <feature type="domain" description="Activator of Hsp90 ATPase AHSA1-like N-terminal" evidence="4">
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        <source>
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        <source>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
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        <source>
            <dbReference type="EMBL" id="WWC70308.1"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <sequence length="404" mass="43604" checksum="F750A5F0A596475B" modified="2016-11-02" version="1">MGEPKPLTAYQQTYHWRNKNCAPFAHDWVKKSLPGLKVEDGESYAEIIEVTNVSGDCDLGQRKGKLLTIYDLEVEAKWSGKAKDGSEVNGTLKVPEVSHEAIDGLSDYVYEWRVTSDSSASSSELLSIIKSKFPSILSAKFNTFRAELLAAYGNPSADDSLPTSGTSTPQPGVSSSSSYSPAPPAKPVESEKKAEETKKDVGKTVTVEQKADLQASAEDLWGLLTDENKVPMWSRSAAKINLTPDFPYELFGGNVRGKIISVEAPKKLVQTWQVRSPSWPSDHYGTMTLSLDQGSSSTSATFTLDGVPAGNEAEVEKALDAFYIRGLKQMGLVLSSSSRSYSTPTSRPPTRTTQKPKKLRKKTSSSSPSKWSSSTLIGSGVVLGLSAVLVGIVYTSFPPSSSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I2G5</accession>
    <name>A0A1B9I2G5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA recognition motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_04180</name>
        <name evidence="8" type="ORF">I206_104242</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="GeneID" id="30172549"/>
    <dbReference type="KEGG" id="kpin:30172549"/>
    <dbReference type="OrthoDB" id="5411533at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="RRM_UHM_SPF45_PUF60"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G-patch domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040052">
        <property type="entry name" value="RBM17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288:SF8">
        <property type="entry name" value="SPLICING FACTOR 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288">
        <property type="entry name" value="SPLICING FACTOR 45 SPF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="151"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="228"/>
            <end position="321"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="347"/>
            <end position="397"/>
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        <location>
            <begin position="26"/>
            <end position="40"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="59"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="86"/>
            <end position="104"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="174"/>
            <end position="183"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
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            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCF49658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC70292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="652" mass="70295" checksum="E0090D99D712E3B9" modified="2016-11-02" version="1">MSLYGGIKFASSAPAEEQSNSTNTAGPSTSSISKPPSGSINATQTTASVSEAKPQQKTGEWSAALKFAPRVNKPKPTTSSRPIGFTTTSTSNSGLGSGSNSPTTVSESKIDIIRSAEPTVILSTTGVGLGTGKIDEDEIQFGLDGLPLAKAPAMTLNSKPPPGVKRGREGEEKKKKKKKKKKNNFGQPYISNFDPDEQYDPNRPNDLGEYQAYRKRLREEKRLKLIEERKRKAQGLSSDESSYYTDSEDEAPRRDAPKMFAPPKIYTETPSAQPPVQSSNFRPPPPLTSSAPSVSSGDDAYARRAALSQQPPPATGDDAYARRLALSQQVASGDDAYARRIAMSQGNAAPPSFALPSSAPPPTFAPPSDAPVSDIPGFGSQTQASAPSHAPPIASDTANQEKEDFAKMLEDRKKAAEAIAAKFKALAGGTTGPSIPTPVSIITPQASEEDSGTGTFAEKMMRKWGHQEGSTLGIRNEGLLHALSAEHIKDEVPNVGSEKLSKRQITKQKIEKANLKNKKWIQNPNSRGKIINKNEDLKSINEKLKKGEASRIICLIGIIDNVDDIDEDLSDEIGEECSKYGIVERVVLHIVEPPPSDPLESLRIFVVFSGMAGAWRATKELDGRFFGGKKIRVTYFDEGRFDRGERDGEILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I2H4</accession>
    <name>A0A1B9I2H4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Kinesin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_04261</name>
        <name evidence="10" type="ORF">I206_104164</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010956.1">
        <property type="nucleotide sequence ID" value="XM_019155998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I2H4"/>
    <dbReference type="STRING" id="1296096.A0A1B9I2H4"/>
    <dbReference type="GeneID" id="30172630"/>
    <dbReference type="KEGG" id="kpin:30172630"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000096">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF13">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF19 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="5"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="730"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="837"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="994"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="741"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="837"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="861"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="885"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="130"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCF49737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC70214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1044" mass="112910" checksum="603A38B0EE0AD0E6" modified="2016-11-02" version="1">MDANAIQIAVRCRPWHPTKELPFISQPSNQPYFYGDGNMGATSTKPVAPGALRNVVEVIDSRELDFDKPQDPNEAKRGAPMVGRRYKNRKYVFDQVFSMEAGQEVVFERTAKPLLPGVLDGYNATVFAYGATGCGKTHTISGTEEQPGIIVRTMKELFDLVEDTKLQYDTYFQMSMVEIYNETIRDLLSDDYPACPPGGLKLLENEKERVKVANVTNKTPTSVEEVMALVMLGNDRRSTSFTARNSTSSRSHLVLQINVVRNERGSDVDVAKSTVTQCSTSATLSIIDLAGSEKASVNRGQRMKEGANINKSLLALSGCISALCTPPNRGVRQHVPYRDSKLTRLLKFSLGGNCRTVMINCISPSSKDIEETNNTLLWADKAKKVSTKVSRNTAGVELRTAQWIQKIVILEATIKSLESQLAAGHTASSGMQQRRLNKARVDAKDEMSRVQKELDELLPVILEGSEMEALWNASILQVEALDTRLADIDIEIQSGRSSEDALKEKTHIRNLIQQQDSSYRFNSEIQSGIQNKSLKNITLSNMLKKAEERGFDDDLKEAKYEHQLEIMKHQLHITKSVSAAKERGLRDYIAQQADQATKSASLLSRFTILLQNEISTLTSESDVDLVLKRLKSLMGTVDSSVATLFGDASADVPSLASSARLPVSLAAPSPRRPSARQSIAASPKRFIKKVSPKKHVPLRPSLFGSTSLNADKEKKGLRWRDEVGEGKIDDRSIAPDCPVFSSPSTNNEMSIGNISTATDSSSSEWEDVKARTKLPLPTSSKPLSPVIPVSLRPLNTHSSMSASASSSTLPAIPPPVEEVPAWKQMRMARSLNSFQPITTISEESPTKSPIGLGKPSGAGAMGPPARPGPLGELQNNPSAVGPRPSSSMSHSTSMSNLLRPTAASAAKASAGNGNTSSTSIFANVKIPLNSFSNGSPTGIPGPTQSLPSRRVSLIGPARHDRPKQRLSMLPPSLSSHASSDASFSGIMKGLPIPSSGGGNTSVLSGGARRVGGPRNSIMTSSTSGLPRGPRPSITPNEGSKPVWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I2K5</accession>
    <name>A0A1B9I2K5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">tRNA-dihydrouridine synthase 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_04222</name>
        <name evidence="11" type="ORF">I206_104203</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010917.1">
        <property type="nucleotide sequence ID" value="XM_019155959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I2K5"/>
    <dbReference type="STRING" id="1296096.A0A1B9I2K5"/>
    <dbReference type="GeneID" id="30172591"/>
    <dbReference type="KEGG" id="kpin:30172591"/>
    <dbReference type="OrthoDB" id="9977870at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF31">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20A_20B) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="9">
        <location>
            <begin position="153"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF49698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC70253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="410" mass="46255" checksum="B009A84F3DF77DA5" modified="2016-11-02" version="1">MPSVDFDATDEQLYAELPEPLTLPPSELLSHYEPNILAPLVRCSKLPFRHLVSLYETQITHTPMILAEEFSRAQIARISDFSTSSCERGLYWMNPSLNSNSNKKVKQVIRLNHPEDDRKNDTNDLITYYKGNYQNRIPSTPIKPNKNSELIRGNLIAQFASPNSKSLIDACELISPFVDGIDLNCGCPQRWAYNEGIGCALLRKPELVREMIRSVRDRMGWGWSVSIKIRIDPDQKQTETLIRNALQAGISYLSIHGRTRHQPSTDPVNLEGIKFAVETVNGQVPCTGNGDIWTYEDVINMREKTGVTGVMAARGLLANPALFSNYSSTPSHVVSQFISLSTSYGLIFPLFHRHLAYMLENNFTKNEKVWFNCLSSSSAAIDWLENRGLDWRSGKGGMWDGRRSRGVLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I2U7</accession>
    <name>A0A1B9I2U7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligoribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_04386</name>
        <name evidence="7" type="ORF">I206_104039</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oligoribonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011078.1">
        <property type="nucleotide sequence ID" value="XM_019156120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I2U7"/>
    <dbReference type="STRING" id="1296096.A0A1B9I2U7"/>
    <dbReference type="GeneID" id="30172755"/>
    <dbReference type="KEGG" id="kpin:30172755"/>
    <dbReference type="OrthoDB" id="270189at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06135">
        <property type="entry name" value="Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000003">
        <property type="entry name" value="Oligoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022894">
        <property type="entry name" value="Oligoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003765">
        <property type="entry name" value="PRK05359.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046:SF0">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="5">
        <location>
            <begin position="13"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCF49859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC70092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="213" mass="24385" checksum="9C57F5B7B89B072D" modified="2016-11-02" version="1">MTEFTPLEYDDGPLVWIDCEMTGLDFLNDKIIEIAVIITNGNLEPVDEGINYIINTSKEVLDGMNEWCINQHGKSGLTKSCLESKDSYEQVIEKVLKYIKKWIPEKGAGILAGSTVHADMRFLMIGMPEIMKHLSYRIVDVSSIKEICKRWYPSIRQQDKARRTTESAHRALDDIKASIEELKFYRETIFIPVENPTKRGTTPENERQGKTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I2V0</accession>
    <name>A0A1B9I2V0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_04408</name>
        <name evidence="2" type="ORF">I206_104017</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
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    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019531">
        <property type="entry name" value="Pmp4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15460">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15460:SF3">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013674">
        <property type="entry name" value="PXMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCF50014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC69938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="225" mass="25614" checksum="FE16013BBF6097F6" modified="2016-11-02" version="1">MSSIQQFLMNPANQEWLAILKGARNGLVYGVKIRFPHALVMTLLFSHKPWPAKIKGIINATRTHATNLCKFVTIYKLMLLLQKKLNGGKERDLDTFIAGGLGGFWVFGERTAINEQIVLYVMSRVILAFLPRLYENEIGGKSFKSPISPLNHPLPSLNSIQSNPKPIPPANLPFTIISTLSWAGVMYLFRHRGERIQPGMNNSMRYLYHDSEVWTNLKTLLWHNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I407</accession>
    <name>A0A1B9I407_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Septin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_03577</name>
        <name evidence="7" type="ORF">I206_105521</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011477.1">
        <property type="nucleotide sequence ID" value="XM_019155323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I407"/>
    <dbReference type="STRING" id="1296096.A0A1B9I407"/>
    <dbReference type="GeneID" id="30171946"/>
    <dbReference type="KEGG" id="kpin:30171946"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000328">
        <property type="entry name" value="Septin spn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="14"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="322"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCF50258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC71563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="388" mass="44005" checksum="A06919639925C1CF" modified="2016-11-02" version="1">MASRASRGRKQAKKGVQLTLMVVGASGTGRTTFVNTLVESVLLEHRTANLLVDPSNPHSGLDANSVQQAASQANVEEPIRIKPVNVELEEDGVRIALTVVDTPGFGDGIDNEYAFQEIASYLERQYDDILAEESRIKRNPRFRDNRVHALLYFIPPTGHALREMDIELMRRLSPRVNVIPVIGKADSLTPTELRAFKKRVMEDIEYYNIPVYNFPYDAEEDDEETIADNSSLRALLPFAIVGSEEEIMIDGEPIRGRRYPWGIVEVDNPDHSDFSRLRSALLMSHLTDLKEITHDFLYENYRTEKLSRSVGGNDPDSSILPEDMANQSVRLKEEQLRREEEKLREVELKVQREIQLKRQELLAKEDSLKVLEARLAAQGNGHSRDGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I413</accession>
    <name>A0A1B9I413_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Origin recognition complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I206_03576</name>
        <name evidence="14" type="ORF">I206_105522</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">ORC is composed of six subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ORC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011476.1">
        <property type="nucleotide sequence ID" value="XM_019155322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I413"/>
    <dbReference type="STRING" id="1296096.A0A1B9I413"/>
    <dbReference type="GeneID" id="30171945"/>
    <dbReference type="KEGG" id="kpin:30171945"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000199">
        <property type="entry name" value="Origin recognition complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054425">
        <property type="entry name" value="Cdc6_ORC1-like_ATPase_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF23">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22606">
        <property type="entry name" value="Cdc6-ORC-like_ATPase_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="437"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="286"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="340"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCF50257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WWC71564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="857" mass="97918" checksum="D43EEE7A70A71250" modified="2016-11-02" version="1">MTIIPSTPRRSTRGNIFTPSPTSNNSKLLKSTKLNTIYKWNSAPLNSLNKEEEEEEGKIKYNSFSKIIKKNNRNDLTTITPSNLINRKIKIEKEDEESRFTIGDGVLINLEGGNQGVAILIGLYEDFNYYKKNNHDNDDQEKEEEEEEENDDNDNDDDFEEKKSKMMAEIHWAFRKSDLPSIMKNVNIEENEVLLAASLNSKPVTSIIPIEYLIKTIPIYSKQFYRDQFPETKSKVKGWSYIRQGIYWCYRAYDKFAKGGRDWKIDIDFWRENGKKTSNWNVPFQSINQFHNDSDDDDDQEESEDDHGSLIQEEQEEEEEESDQNESSASEEEEEFKTENRKRKRVKNGRQPRKKSNKKLKRTILNLPRKKKKPHPKSSTKNNLPCSEILLENLPIDPYERALRLLHVGSTPESLPCREEEFIDVLSKVEEGVESGGGGCLYIAGVPGTGKTATVHAVVKELKRKAEDGELSTFSYVEINGLKIPSPQHAYSVLWEAISGSKGASSKTALKGLENHFSRKGGGGVRGPRGHTFVVLMDELDQLLTAKQDVVYNFFNWPTMRDSQLFVIAVANRMDLPQHLAAKIKSRIGLQTILFQPYDRASLISIVQSRLIPHPLSPSGDPKVLLPDAIALAATKMAGTNGDARRVLDACRRAVEVTIETSKKNPNKIFDEMVNENQQHQHPHPHPVTAKEMMLILNSMSNSTISKFINECSINQKMLLTCLIRCIRREGINEIFWKNLKNDFDNLLKSFNFFGEKGQENDFIRIIDVNENEEEENNYNYNNNTNLLLSNSELLIILNSLISSHALIINNNNNNNQQEQQFKIFDEKKIILGLEIGECGRVLINQGENWRRALAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I4F4</accession>
    <name>A0A1B9I4F4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_03727</name>
        <name evidence="4" type="ORF">I206_105364</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011624.1">
        <property type="nucleotide sequence ID" value="XM_019155470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I4F4"/>
    <dbReference type="STRING" id="1296096.A0A1B9I4F4"/>
    <dbReference type="GeneID" id="30172096"/>
    <dbReference type="KEGG" id="kpin:30172096"/>
    <dbReference type="OrthoDB" id="17458at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041516">
        <property type="entry name" value="LACTB2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050662">
        <property type="entry name" value="Sec-metab_biosynth-thioest"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131:SF0">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17778">
        <property type="entry name" value="WHD_BLACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="34"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF50405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC71409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="507" mass="57072" checksum="15BC7AE18A18D48C" modified="2016-11-02" version="1">MVIGNLERLSDVEKLSAHVTRLLGQNPGLMTLQGTNSYLLQPPSNPHAPLILIDTSSPHTATQYIDLLMTHLHHLALESGTRETHFESAYAQASLKNLPEDKVDEVKASIVENRSKDPRHTEIELLEYGPGSGWKSTYTKERKLPNIDHIILTHRHLDHVGALPLLLKTLKEKGCNIPKIWKLPSPDEEQLALNEKDRPTSDAEIWNSLPKGTYHSFSPFQPFHPIIPGLMISIIDPVYKHLLRHDKDGRPKWNEVPEIARVSLRCLKTPGHTQDSISLVMLEGEKGVFTGDTVLGSGTTHFSDLASYMTSLRTLLALKPNVLYPAHGPHIAKAEKAKAHLQNYITHRQQREDEILSILQKSAEGNDGKTVVDTIIEMKIQLHQKLEEENDAKGPLMFDRRKPKKLSDNPFEDERKALEKAEQDGSRPAKALPLSVLVRILYKSEDEKLLTAAGKNVVAHLVKLEQEGKVRKLTGKWCKLIAGTVGEKLEDIEVWEYIGEKEHMKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I4K4</accession>
    <name>A0A1B9I4K4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_03777</name>
        <name evidence="3" type="ORF">I206_105313</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
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                <person name="Sun S."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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    </evidence>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">CBS 10737</strain>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
        </source>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <location>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
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    <name>A0A1B9I5H0_9TREE</name>
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    <reference evidence="20" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
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                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="20">CBS 10737</strain>
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    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="21" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 10737</strain>
        </source>
    </reference>
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            <dbReference type="Rhea" id="RHEA:14761"/>
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    <comment type="cofactor">
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            <name>pyridoxal 5'-phosphate</name>
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    <comment type="pathway">
        <text evidence="4">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
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        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
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    <comment type="similarity">
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    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="7"/>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF50770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011989.1">
        <property type="nucleotide sequence ID" value="XM_019154586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I5H0"/>
    <dbReference type="STRING" id="1296096.A0A1B9I5H0"/>
    <dbReference type="GeneID" id="30171195"/>
    <dbReference type="KEGG" id="kpin:30171195"/>
    <dbReference type="OrthoDB" id="65434at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0017059">
        <property type="term" value="C:serine palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:pyridoxal phosphate binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="serine palmitoyltransferase 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF3">
        <property type="entry name" value="LD36009P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="19">
        <location>
            <begin position="277"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="19">
        <location>
            <begin position="580"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="66"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="8"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OCF50770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="WWC68546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="718" mass="78907" checksum="C14A5FA431912482" modified="2016-11-02" version="1">MPRPTRKSASGGASTPPSSLSSSPPSRPSYPAISLRSSSPSSSSSGGKEMPNSNVLSARTSLLNVLTRPNHSTPSTNIISSENNSSDEDTIYSDQSTLSGSSYASSIINGSIVDKQHLSSEDIARVYENYLEKPFVYTKSTIKHSEFGHCNNPNWRWTSQWNPDEPIHPEEEPHPPYFTLLTTYISYILLIVIGHMRDFFGKRFRPAEYAHLMPQNGYAALNSDFDSFYTRRLKQRLEDCFARPVTGVAGRTIVCYDRSSNDENKTFTLTGTTTRALNVSSYNYLGFASSTGGCADAVEACIKKYGVSGAGPRHDASTLDLHVQTENLVARFVGQESAMVVSMGYATNSTTIPALVGKGCLVISDEFNHASIRFGVRLSGASLRSFKHNDVNDLERILRDVISQGQPRTHRPWKKILLIVEGLYSMEGSLVNLPLLIELKRKYKFYLYVDEAHSIGAMGPNGRGVCDYFGVDPREVDILMGTFTKSFGAAGGYVAGSKAIMDRLRLRSHATCYAESVSPVLLTQIISSMGSIMGVAPPLATPAEEDKSDSLSIVSRPQAYGPAPSYILPAWMKLPLNLLNGTEGRERLRRLAFNSRYLSSGLRKLGFIVYGHRDSPIIPLLIYNPGKMPWFSQLMLDRLGPDKTPVVVVVVAYPATPLITSRVRFCLSASHTKNDIDLILRACDEVGDLLGMKYGKQTMNVEEIISSAEELVASSKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I5J0</accession>
    <name>A0A1B9I5J0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">V-type proton ATPase subunit C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_02860</name>
        <name evidence="8" type="ORF">I206_102509</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. Reversibly leaves the enzyme after glucose depletion, causing the catalytic subcomplex V1 to detach from the V0 section.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the V-ATPase C subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF50803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012022.1">
        <property type="nucleotide sequence ID" value="XM_019154619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I5J0"/>
    <dbReference type="STRING" id="1296096.A0A1B9I5J0"/>
    <dbReference type="GeneID" id="30171229"/>
    <dbReference type="KEGG" id="kpin:30171229"/>
    <dbReference type="OrthoDB" id="6605928at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14785">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1460.10">
        <property type="entry name" value="subunit c (vma5p) of the yeast v-atpase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1180">
        <property type="entry name" value="Vacuolar atp synthase subunit c, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004907">
        <property type="entry name" value="ATPase_V1-cplx_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036132">
        <property type="entry name" value="Vac_ATP_synth_c_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03223">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118203">
        <property type="entry name" value="Vacuolar ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00053565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCF50803.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC68579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="396" mass="44398" checksum="1C9523CC95E351C7" modified="2016-11-02" version="1">MPSDLSYWLISAPLKDGDPNVMLNEVSNTIGKEVEAATWEIPELKAGTLSSLLTLSDALPKLDSQFTSTVSKLLDTLRSLVSEDPAKVAQHARVNDRPAEEYLLGGGGGFRWDKGRWGSGGKVLEVVDALTKEMNSIDSTQKQKSQSYNLTKGGLTTLQRKQQGNLSQRSLLDVVNKNDLVENSEFLETLIVAVPKNSQKDWNEKYERLTSMVVPRSTQQIAADDDYFLQTVTVFKKVKEDYIHKCRENKFIVRDFKWDDSALEKQKKELAELAVEEKELWTELLRLTRINFSEAYQILAHLKTVRLFVESVLRYGLPADYAGVIVKPEPKTAVKTLRSLSDHYTYLASASRGPSTKKTKSGGNTAGSEDVGGEWASVMEAEYYDFVLFEIPKVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I630</accession>
    <name>A0A1B9I630_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_03030</name>
        <name evidence="4" type="ORF">I206_102677</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="OCF50968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1296096.A0A1B9I630"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF9">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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            <end position="55"/>
        </location>
    </feature>
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            <end position="406"/>
        </location>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC68743.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1B9I6R9_9TREE</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="4" type="ORF">I206_102948</name>
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        </lineage>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the gemin-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF51233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC69012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012452.1">
        <property type="nucleotide sequence ID" value="XM_019155049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I6R9"/>
    <dbReference type="GeneID" id="30171668"/>
    <dbReference type="KEGG" id="kpin:30171668"/>
    <dbReference type="OrthoDB" id="428895at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035426">
        <property type="entry name" value="Gemin2/Brr1"/>
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    <dbReference type="PANTHER" id="PTHR12794:SF0">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12794">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04938">
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
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            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF51233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC69012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="453" mass="50455" checksum="ACCFE9CB650353EE" modified="2016-11-02" version="1">MARPGQAALRRKRAREEMEISSSTTNYPTSHYDYVDTDNVEQGEVEEQVAAQGDNPRSQCLPVGILPEDFDGTPLDGSQYLAMANRDNADLPFAKSVNNPFKIDQPSTSMINEKNNATASSSSSSRHPALPKESWEAIFPLHFQGYRKHIRSQLSSSDSDTTPYPADYPPLPRATVRPEWYAFINGYIPQTKNKKGKEKAKPKPILTEEELMNIALGGEEADMEITQEAVEAEVVESQVVVKTSRGNEKRVGKPREPLLSVLRNLTPSQALIILSHFSLWITESLENAPPPLPSSPEIPISMLDKDQSFIKAENSINSSSHLSTNYFNWIFSLLLIIDDYLTSDEISILRELARASMKVAGHRWITGVVGKDIGENWVLGNEWKVNSLKQTGDKVGIELSVERGKEDLEQNSDGCVSENRVDEVLARSWMIVHAVSAGWGQKDLLMELNSLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I720</accession>
    <name>A0A1B9I720_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tryptophan synthase beta chain-like PALP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_02054</name>
        <name evidence="7" type="ORF">I206_104522</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012559.1">
        <property type="nucleotide sequence ID" value="XM_019153819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I720"/>
    <dbReference type="STRING" id="1296096.A0A1B9I720"/>
    <dbReference type="GeneID" id="30170423"/>
    <dbReference type="KEGG" id="kpin:30170423"/>
    <dbReference type="OrthoDB" id="271064at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008721">
        <property type="term" value="F:D-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030378">
        <property type="term" value="F:serine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018114">
        <property type="term" value="F:threonine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01562">
        <property type="entry name" value="Thr-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000005">
        <property type="entry name" value="Threonine dehydratase catabolic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43050">
        <property type="entry name" value="SERINE / THREONINE RACEMASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43050:SF1">
        <property type="entry name" value="SERINE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="5">
        <location>
            <begin position="23"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCF51340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC70571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="407" mass="44616" checksum="09DCD61CBA162352" modified="2016-11-02" version="1">MAGLSTTLPLTPESVRIAYSKIKDHVHRTPLLTSKTLNNIASTSSSNSNSAPKFNIYFKCENYQRIGAFKARGAFHAITHLIEVLGLDELRRRGVVTHSSGNHAQALALAASHFSIPAHIVMPTISTPSKIEGTRTYTDHIYFSGSTSDEREAVVKEVINKTGAILIPPYDHPDIILGQGTTALELQEQYNEIKIEKNEKPKLKLVLTPLGGGGLTSGICIHFSNQLNVKVIACEPNYQGGNDFEIGFKNTNPPKRIEKVNTLTIADGLRTPVGEIPWKIFTTTTTTTTTNKTSINNEKKNLENVFSVSENQIENSMKLVLERMKVFIEPSGAVSLAVVLYNQEFRQWVYEEQQKEGGEAWDIVVIFSGGNTTIDAILGIFGNSTDKEREEGIDGLDGKATAENVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I7H3</accession>
    <name>A0A1B9I7H3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_02115</name>
        <name evidence="2" type="ORF">I206_104581</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012620.1">
        <property type="nucleotide sequence ID" value="XM_019153880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I7H3"/>
    <dbReference type="GeneID" id="30170484"/>
    <dbReference type="KEGG" id="kpin:30170484"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCF51401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC70630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="223" mass="25307" checksum="8C6DD441DF8EE4BB" modified="2016-11-02" version="1">MSDNSSSGLGLPLTMRDYTDLPVPINSHGEEATTVVNLSYIAESWRDYIKKYGIPESKSRNGQWYCDWSRYDPQLMTITKRLEDKFPNKRPDTIRNATLPYLTAISQIDGYLTLKPSEKASYVKMVNGKSGSKQLSQAYTDYQKSGEDILNIMTDRITKPDNLDLENPLFTLTTNINSNPCLAFWDEMKSKGEADRFINHRKVFQDLLSKATSAHGQSSGEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I7Q1</accession>
    <name>A0A1B9I7Q1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">H/ACA ribonucleoprotein complex subunit CBF5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">H/ACA ribonucleoprotein complex subunit cbf5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_02262</name>
        <name evidence="12" type="ORF">I206_104724</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>uridine in 5S rRNA = pseudouridine in 5S rRNA</text>
            <dbReference type="Rhea" id="RHEA:47036"/>
            <dbReference type="Rhea" id="RHEA-COMP:11730"/>
            <dbReference type="Rhea" id="RHEA-COMP:11731"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine in snRNA = pseudouridine in snRNA</text>
            <dbReference type="Rhea" id="RHEA:51124"/>
            <dbReference type="Rhea" id="RHEA-COMP:12891"/>
            <dbReference type="Rhea" id="RHEA-COMP:12892"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012767.1">
        <property type="nucleotide sequence ID" value="XM_019154027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I7Q1"/>
    <dbReference type="STRING" id="1296096.A0A1B9I7Q1"/>
    <dbReference type="GeneID" id="30170631"/>
    <dbReference type="KEGG" id="kpin:30170631"/>
    <dbReference type="OrthoDB" id="10250002at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000495">
        <property type="term" value="P:box H/ACA sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02572">
        <property type="entry name" value="PseudoU_synth_hDyskerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21148">
        <property type="entry name" value="PUA_Cbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.10:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012960">
        <property type="entry name" value="Dyskerin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004802">
        <property type="entry name" value="tRNA_PsdUridine_synth_B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00425">
        <property type="entry name" value="CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003280">
        <property type="entry name" value="PRK04270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127">
        <property type="entry name" value="CENTROMERE/MICROTUBULE BINDING PROTEIN CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT DKC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08068">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01136">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dyskerin-like" evidence="10">
        <location>
            <begin position="30"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="9">
        <location>
            <begin position="280"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="408"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="414"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="431"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="463"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00072225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCF51548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC70773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="494" mass="55326" checksum="5249F5C833C0FF06" modified="2016-11-02" version="1">MASLTDGQVTTLQQSEDYAIKSEAVTPKLDTSQWPLLLKNYDKLLVRSSHFTPIPTGVSPLKRDLQTYVKSGVINLDKPSNPSSHEVVAWLKRILRVEKTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCVVRFHDKVVNGEKAVSRALETLTGALFQRPPLISAVKRQLRVRTIYESKLIEYDEKRNMGVFWVSCEAGTYIRTLCVHLGLLLGVGAHMQELRRVRSGITGENDDIVSMHDVLDAQWLFDNTRDESYLRRVIRPLESLLTNFKRIVVKDSAVNAVCYGAKLMIPGLLRYESDIEVNEEVVLMTTKGEAIAIGISMMSTVDLASCDHGVVAKVKRCIMNRDLYPRRWGLGPKAQEKKKMIKKGELDKYGKSIEGVTPQNWKKDYIDYNATNEENVPSTLPTQPQTQATITPIVETEDKKRKRDGESEIAATPSKGDGDKEKKKKKVKTEDGAEREETAEERAARKAAKKEKKEKKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I8I5</accession>
    <name>A0A1B9I8I5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Mitochondrial protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I206_02552</name>
        <name evidence="16" type="ORF">I206_105013</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the ATP-dependent dehydration of threonylcarbamoyladenosine at position 37 (t(6)A37) to form cyclic t(6)A37 (ct(6)A37) in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HesA/MoeB/ThiF family.</text>
    </comment>
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        <property type="protein sequence ID" value="OCF51836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC71060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013055.1">
        <property type="nucleotide sequence ID" value="XM_019154315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I8I5"/>
    <dbReference type="STRING" id="1296096.A0A1B9I8I5"/>
    <dbReference type="GeneID" id="30170921"/>
    <dbReference type="KEGG" id="kpin:30170921"/>
    <dbReference type="OrthoDB" id="10265862at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061503">
        <property type="term" value="F:tRNA threonylcarbamoyladenosine dehydratase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061504">
        <property type="term" value="P:cyclic threonylcarbamoyladenosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00755">
        <property type="entry name" value="YgdL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000125">
        <property type="entry name" value="tRNA threonylcarbamoyladenosine dehydratase 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43267">
        <property type="entry name" value="TRNA THREONYLCARBAMOYLADENOSINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43267:SF2">
        <property type="entry name" value="TRNA THREONYLCARBAMOYLADENOSINE DEHYDRATASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="14">
        <location>
            <begin position="94"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00060084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCF51836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="WWC71060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="474" mass="53684" checksum="C681829C7AE04B3B" modified="2016-11-02" version="1">MPISELSTRQSIFLTAAATAIATTSVILSYQALRREHRTTRLKKQVGEDVEEWERSRAGSGLGTPDEKIERVVRQDREWKKGEFDESLIREQLTRNYNFLGEESMQKVRNSYVVVVGCGGVGSWAALMLLRSGVGRILLIDFDLTTLSSLNRHACATLEDVGTPKVIATQKFFRKIAPWAEVDVQVGLWRKGSEAEQWLEGADWVVDAIDNLETKADLLSHCHKKGIKVFASMGAGAKKDPTRVQISDISTTQEDPLARSVRRKLRINGITGGIPVVYSTEVPSEVKLLPLPEEEFQKGAVKELQAFDDFRVRILPVLGPLPAIFGLEIATYILLDIAGKTLTDYAEIKNRKKVYQSLEKGLLRSEKQFKNLEHMERLPISWEDIGFVFDELYNGRTSLPPYEIVPKFAIVRWDKDQILDIGNIVVMSSKDAMKHEKICLKDGQNLVEVYGKEVVDKIRRKSEEARRVLSWRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I8Q2</accession>
    <name>A0A1B9I8Q2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_02612</name>
        <name evidence="2" type="ORF">I206_105072</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC71119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013115.1">
        <property type="nucleotide sequence ID" value="XM_019154375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I8Q2"/>
    <dbReference type="GeneID" id="30170981"/>
    <dbReference type="KEGG" id="kpin:30170981"/>
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        <property type="component" value="Chromosome 6"/>
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        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630:SF6">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCF51896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC71119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="37957" checksum="ECF113C14110F134" modified="2016-11-02" version="1">MTSITQTQSQNTGTGTTGILKLRGHEEEYLPELKTRGWTVVKNVIPQDRAKEYEDKAYKWLESFGKGFDKNDRETWKVKNLPWFSKGGLFNRHGAAHEQWAWDIRSEQGIIDTFSKIWGTDELLVSFDGVNVSLPFKNEDLGNRGKPWPHVDQSPNKKSKECIQGIANLVENGLNDGGLMILDGSFSLYNKFFEEHENLKPENGWDWKDSFSYPEETLKWFEEKGCKWKKIQAGPGDLILWDSRTVHYGDAARGDRARVATYVCYKPAKGISAEKLEERKTAIKEYAGTSHDPINFRLTGTNVDGPLSEDEVQLPKQPAVLSHRAQQLAGIVSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I940</accession>
    <name>A0A1B9I940_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_01407</name>
        <name evidence="2" type="ORF">I206_103590</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
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                <person name="David-Palma M."/>
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                <person name="Mohammad A.W."/>
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                <person name="Heitman J."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="Springer D."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Dewar J."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
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                <person name="Litvintseva A."/>
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        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="459"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="533"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="94"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="574"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="588"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCF52224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC69544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="599" mass="64461" checksum="5A09E4A738ED7743" modified="2016-11-02" version="1">MSDNIGSSSSPYSPSISTQTNEKNENTRRSLANDDEYIPTLTQDITSISPEINTKSLPTPGVDDVNIERTLSTVPIDDSDVPPITSKKLSRTQLFFVAATVTFTMCNSAAGGQTLNIGLPTIQKDLKMIDSDLQWIASAYALTNGCFLLLSGRLADVHGRKLVFITGVLWYALWTLIGGFMKNGAGLVVTRALAGCGAAMSTPSAVGIIAGNFTGKARSTAFACFSAGAPVGGAIGLIVGGVFVSYVKNTWRGALFLLAGMAFAIACISLWTIPSDFSHSDDKRVDWIGAALVTVGLILLQFTISAGETASNGWKTPYIIALLVVGVLLVVAFFLWERHLINNTSRPPLMRLQLWTRAKGRLAAVYFIGFIAWMGFVSLFYHATLFYQQIQETGPLGAMLRFLPTSVSGVLCNVIVAFLISKVPTQWLVCVGLIATGMGNVCFALSWQDTNYWRLPFNGMWLSVMGADFLMATGLIFVAALSLPDEHSVAGALFQTLIQLGGSFGLAITTVMSDVQFQKAINIGKTYKESLLLGYHAAFWLGAATSFLALFIALIALRGMGTIGKGINRSKKIEENPKDTSTELQITKQEKANEDKIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I9X5</accession>
    <name>A0A1B9I9X5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphotransferase</fullName>
            <ecNumber evidence="11">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I206_01635</name>
        <name evidence="16" type="ORF">I206_103359</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-glucose + ATP = D-glucose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17825"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:17826"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:22741"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="11"/>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013565.1">
        <property type="nucleotide sequence ID" value="XM_019153404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I9X5"/>
    <dbReference type="STRING" id="1296096.A0A1B9I9X5"/>
    <dbReference type="GeneID" id="30170004"/>
    <dbReference type="KEGG" id="kpin:30170004"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000034">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.367.20:FF:000005">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019807">
        <property type="entry name" value="Hexokinase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF30">
        <property type="entry name" value="GLUCOKINASE-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00378">
        <property type="entry name" value="HEXOKINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="13">
        <location>
            <begin position="9"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="14">
        <location>
            <begin position="208"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
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                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
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                <person name="Goldberg J."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
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                <person name="Zeng Q."/>
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                <person name="David-Palma M."/>
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                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
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                <person name="Cuomo C.A."/>
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    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
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                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
        </source>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle</location>
            <location evidence="12">COPI-coated vesicle membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Chromosome 4"/>
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    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
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        <property type="entry name" value="Coatomer_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="COATOMER SUBUNIT ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043">
        <property type="entry name" value="ZETA-COAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
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    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
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        <location>
            <begin position="22"/>
            <end position="204"/>
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    <feature type="domain" description="AP complex mu/sigma subunit" evidence="14">
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            <begin position="60"/>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004255"/>
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            <dbReference type="ARBA" id="ARBA00045555"/>
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    </evidence>
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            <dbReference type="RuleBase" id="RU366053"/>
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        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="OCF52641.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC69126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="204" mass="22015" checksum="0A65A5E5EDBC66F4" modified="2016-11-02" version="1">MTMSNLSLYTVTALLILDADGQRVLAKYYNPPHQNTPGSGIASDLGVGPGGPGMGGLTSLKEQKAFEKSVFEKIRRGGGEIHPLPPHLIITRTIVDLNFIIVGPLSTSNELMLNQTLSAFSDAVHLLLRGQIEKRNVLEGLDLVLLAADETVDDGIILETDAAAIAARVSRPKADSTDIVINEQTLLNAYTSFRDKVSQRIQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IB91</accession>
    <name>A0A1B9IB91_9TREE</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_01960</name>
        <name evidence="3" type="ORF">I206_103035</name>
    </gene>
    <organism evidence="2">
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        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC69099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013886.1">
        <property type="nucleotide sequence ID" value="XM_019153725.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A1B9IB91"/>
    <dbReference type="STRING" id="1296096.A0A1B9IB91"/>
    <dbReference type="GeneID" id="30170329"/>
    <dbReference type="KEGG" id="kpin:30170329"/>
    <dbReference type="OrthoDB" id="2564267at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="135"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="310"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="438"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="492"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="641"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="817"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1052"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="292"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="688"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="699"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="826"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="859"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF52667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC69099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1076" mass="120225" checksum="3F901BFC06DBD322" modified="2016-11-02" version="1">MSLSRLQLAAALMEYDNDSDLASPNTQETFYKDHRASAIFQPFNKAQAEARRHKILSQPPPSLPSPLGESSRALNDQRRQSTSELNDHVDRPKSQNQSFRQSTISDFRVTPAGGRSINLTTNDIEEEEHLKNGEKHDVDVERWGLPSHLVLDESNQKPKLDTRKSVNSIVPKPEASSIGSRIKSIHVEDVLDDTDLHKQIYEQSGYIPFEQRQEQRESNRRKRNHSYDFSTSTANALSSGAQIRELIENQRERPSTVMGFTSKNHERDRKLSDPRMIPLPNTPGSLFNSRTLSSGSGWNSPPPGKMDEDLENQDIVNDEPNPFALPAPPPELGSRFDPKILQTQRQPSFDQDKRSYSRSSGIILNDHQQPPYTSRSRSTFYPQEEEYDDTEYIEPNPLVSPSFKVPNKVWEDIPTPEQYGRPLKPHKYRNNPPKPLDRLTMLRPKTLIMPSSLANRYSPPPPQIKLPEGYTLGEKPLPPGAKTQGERPKSGFNHLSISQRTFRSSLMVNGLHDEEFVGGATEDGEMGIKGRDLDVGALERRPGKLFGRSLMDELEARKSAQKGKQRVFTGDSRPAMMARSSMFEPPTISLSPTSPPLPGSANSNRPQSMHPIGNRAPLLSFDSKGDIHPTSPDNLGIPDQGGRISKSKSVFGVDQIWEKELAKLKLIQEEDRRIAEFQKMEEEEKELKKMKRKSKKGKGKEILPDLKIPKESVEEPSDISPIARAADLPPALQYSPEKAPSRRLSQEEGEDVEESRQGGVGSYDDGNGEEVNAPHDFVGTLNRSIRDENTDEDDSEEDIPLSKLALVKSRLSASTRNSILILKEPESEDDSDEDIPLSRLPIAPKSPSIITRTRKPLKSLELNLPSSSSSSNLSKSISGKSPMSAEVDDENAEDDLPLAVRQAKTKGLKPITKAEIIEDDLPLGYKHSEKAQAQMQMQIQMQMQMQMVQRQFEEENINRQSMINPYQSWMIPNMNIGMVPPQFNINDPYVGMGFTPSIPNLGINLPINMNMGMGIGMGNPQINMNMGGFVQPNQGNPGEAIDHWRNDVALAPVGTSDRDSRISGFSSAGREGSIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IB95</accession>
    <name>A0A1B9IB95_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">V-type proton ATPase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_00243</name>
        <name evidence="10" type="ORF">I206_101084</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector. Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the V-ATPase V0D/AC39 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF52942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014161.1">
        <property type="nucleotide sequence ID" value="XM_019152023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IB95"/>
    <dbReference type="STRING" id="1296096.A0A1B9IB95"/>
    <dbReference type="GeneID" id="30168612"/>
    <dbReference type="KEGG" id="kpin:30168612"/>
    <dbReference type="OrthoDB" id="10250083at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.50:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1690.10:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1690.10:FF:000003">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.50">
        <property type="entry name" value="ATP synthase (C/AC39) subunit, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1690.10">
        <property type="entry name" value="V-type ATP synthase subunit C domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_csu/dsu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016727">
        <property type="entry name" value="ATPase_V0-cplx_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035067">
        <property type="entry name" value="V-type_ATPase_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044911">
        <property type="entry name" value="V-type_ATPase_csu/dsu_dom_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11028">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018497">
        <property type="entry name" value="V-ATP_synth_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="V-type ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00059209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR018497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCF52942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC67177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="356" mass="40640" checksum="825020B00012E137" modified="2016-11-02" version="1">MEALGFNIATGFLEGVVRGYKGALLTQANYHNLTQCENLEDFRLQLSSTDYGNFLANEPLPLSTSTIADKATDKLVAEFNYLRTNAVEPLATFMDYITYAYMIDNVILLTLGTLHERDTHELLERCHPLGVFDTMPALCVATNVEELYHSVLVETPLAPYFRDCLSAQDLDDLNIEIIRNSLYKAYLEDFHKFCQTLPSPTSEIMTKILSFEADRRTLNITINSFGTELTKEQRARLFPTIGRLYPEGNNSLARAEDLDSVIQSVDHISEYKTFFDKSNIGSNVNAEDGNESSSLEDEFFKYDVELNKQSFLQQFQFAVFYSFIKLKEQEVRNLTWIAECIAQDAKDRVNDYIPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IBA7</accession>
    <name>A0A1B9IBA7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Catalase</fullName>
            <ecNumber evidence="11">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I206_01943</name>
        <name evidence="15" type="ORF">I206_103053</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 12">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="11"/>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013869.1">
        <property type="nucleotide sequence ID" value="XM_019153708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IBA7"/>
    <dbReference type="STRING" id="1296096.A0A1B9IBA7"/>
    <dbReference type="GeneID" id="30170312"/>
    <dbReference type="KEGG" id="kpin:30170312"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08157">
        <property type="entry name" value="catalase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000001">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF62">
        <property type="entry name" value="CATALASE T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="7 11" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="4 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 11" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="13">
        <location>
            <begin position="33"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCF52650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WWC69117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="559" mass="63492" checksum="5BB91793D26CFF48" modified="2016-11-02" version="1">MSSNDKKCPIKPTEMARNYEVDRNTKSQETVYTTSNGCPVPHPYATQRAGVNGPLLLQDFHLIDLLSHFDRERIPERVVHAKGSGAHGVWECTDGLEDLCMADMFKKGKQCPITIRFSTVGGESGSPDLARDPRGFAIKFKTQEGNWDFVGNNTPVFFLRDPAKFPHFIHTQKRDPATHLAGGDDSTMFWDYLSQNPEAVHQVMILMGDRGIPQGWRFMHGYYGHTLKIVKKDGSWVYAQFHILSDQGVKTFTAEEAASQSADYGQKDLFESIQKGDFPSWTMKVQTMTPTEAEELWEKQRINVFDLTHIWPQKQFPLRTIGKLTLNENAQNYFAEVEQAAFNPAHMIPGIEPSADPVLQSRLFSYPDAHRHRIGANYQQLPVNSPICPFKLGNFQRDGQMAFFNQGSRPAYLSSIEPIQFKDRPYDLNKVHGKFVGEAISYLSEIRPEDFNAPRKLWQDVFPIESKKRFIKTVSGHMKTCREKEILKRQIAIFRHVSPELAEGLEKELGIKGYESIEGMYFNGTHNGMGSRKIPANGMKADEEVVFNNGAPVPRKSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IC33</accession>
    <name>A0A1B9IC33_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_00470</name>
        <name evidence="3" type="ORF">I206_100856</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014388.1">
        <property type="nucleotide sequence ID" value="XM_019152250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IC33"/>
    <dbReference type="STRING" id="1296096.A0A1B9IC33"/>
    <dbReference type="GeneID" id="30168839"/>
    <dbReference type="KEGG" id="kpin:30168839"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21075">
        <property type="entry name" value="DBD_XPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.530.10">
        <property type="entry name" value="XPA C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037129">
        <property type="entry name" value="XPA_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF53169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC66949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="554" mass="64189" checksum="ACE112811C0E8FE2" modified="2016-11-02" version="1">MKGSTKVHALDTDSDLTDLSDIDMKEDEQQSIKNDDTHSSESRNGSNNEGRSIKRKASSVPSVDSDAESDYAAKPLKKKPKKKASKRKTTKSKSTKSKGQSKTKNTKNRNAEDGDVDDQEEKPKKRVLLAKEVHWDDLPDWGDRTDCPLMKLPADILDMCFSTETDLNVRDYVALAGVSKYFRDRLTPKVFHCICWTKNVRRTSYSYLRPEFIVKPENLSIGKHIFSRGFKPWQIAKRTYKYCNRFLDNHYIPCGPRDQWSEAQYIVYKEEQDKWRQQVKQWKIKELRSEMDRKQQEERKEKTYAFLGNYRRTVLGAVAGRKDGEPPVQKDTRGLPIVNQKQAEEENEKAEEPDHADIAAHPKTSRKRKSILTNKKRWTVPDTDTEAEYEVSPHEYLKPDEPFVFDHWPNEWRALAVEWIHLKRINKTAAMRVFKVSEAELLCLSHLLVTNPMSSKNPQQAYLEVAVEALAFRSHGGPQGHKASLQARAERSARMAQSREEKTVQAKKDGTYVYKHRKMQIAPYDWHWKQYDIHGPNGNCDSECEACLHDGWSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IC51</accession>
    <name>A0A1B9IC51_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_00397</name>
        <name evidence="2" type="ORF">I206_100929</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
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                <person name="Chen Y."/>
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                <person name="Litvintseva A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
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                <person name="Heitman J."/>
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                <person name="David-Palma M."/>
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            <end position="99"/>
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        <source>
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        <source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1B9ID47_9TREE</name>
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        <submittedName>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">CBS 10737</strain>
        </source>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Chromosome 1"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:methylation"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
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        <location>
            <begin position="40"/>
            <end position="398"/>
        </location>
    </feature>
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            <begin position="411"/>
            <end position="572"/>
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            <end position="830"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="261"/>
        </location>
    </feature>
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            <end position="784"/>
        </location>
    </feature>
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            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
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            <end position="225"/>
        </location>
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    </feature>
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            <end position="777"/>
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        </location>
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        <location>
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        </location>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IDQ1</accession>
    <name>A0A1B9IDQ1_9TREE</name>
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        <recommendedName>
            <fullName evidence="10">Family A G protein-coupled receptor-like protein</fullName>
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    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_00933</name>
        <name evidence="8" type="ORF">I206_100391</name>
    </gene>
    <organism evidence="7">
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        <lineage>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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            <taxon>Cryptococcaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal/bacterial/fungal opsin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014846.1">
        <property type="nucleotide sequence ID" value="XM_019152708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IDQ1"/>
    <dbReference type="GeneID" id="30169302"/>
    <dbReference type="KEGG" id="kpin:30169302"/>
    <dbReference type="OrthoDB" id="536545at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15239">
        <property type="entry name" value="7tm_YRO2_fungal-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000160">
        <property type="entry name" value="Related to Opsin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001425">
        <property type="entry name" value="Arc/bac/fun_rhodopsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043476">
        <property type="entry name" value="Yro2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286:SF1">
        <property type="entry name" value="30 KDA HEAT SHOCK PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01036">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00251">
        <property type="entry name" value="BACTRLOPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01021">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCF53627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC66489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="35172" checksum="32B0FB1DCEBFCDFE" modified="2016-11-02" version="1">MANTAVDVNPPSGSVQHITSHGSDWLWAVFAIMALTDIIVFFWQFTLPRGQRVFHQLCMFILTTAAIAYFAMASDLGYASIATEFGHMGYAADTTRQIWYVRYIDWVITTPSLLLTLVLASGLPLSDIIALCYFDLVMIVTGLVGGLVVSTYKWGFFAFGCAALFYIWWVLAGPARASAGALGADYKSAFTSSAAILSFLWLLYPIAWGLADGGNVISPDSEMIFYGILDVLAKPVFTFYHLYRLSKVDLSLLQLSSGKFSTSGGVFDQEKHAAAGAPATVGVPAAAGSDAKKGGFFSKRGQRDAVATGAAHDNVHPGRLSEATAVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IE27</accession>
    <name>A0A1B9IE27_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_01113</name>
        <name evidence="3" type="ORF">I206_100212</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019015025.1">
        <property type="nucleotide sequence ID" value="XM_019152887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IE27"/>
    <dbReference type="GeneID" id="30169482"/>
    <dbReference type="KEGG" id="kpin:30169482"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF53806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC66311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="80" mass="8403" checksum="1817158F29AF3DC9" modified="2016-11-02" version="1">MPDINSLSDSTNTTDTTNTNSSSSQTPGRDVNNQNRAVSDSDYMRPSRPAPPPPSQSDRSSSNGTAQTNGANSNTGSSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8KXB9</accession>
    <name>A0AAJ8KXB9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Elongation factor 1-alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_100065</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058220.1">
        <property type="nucleotide sequence ID" value="XM_070202119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8KXB9"/>
    <dbReference type="GeneID" id="30176249"/>
    <dbReference type="KEGG" id="kpin:30176249"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="GTP-eEF1A_C"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="Transl_B-barrel_sf"/>
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        <property type="entry name" value="Transl_elong_EF1A_euk/arc"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ELONGATNFCT"/>
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        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    <keyword evidence="6 9 11" id="KW-0251">Elongation factor</keyword>
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        <source>
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            <dbReference type="ARBA" id="ARBA00023134"/>
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    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="461" mass="50225" checksum="42DFCF67D9D486C0" modified="2024-07-24" version="1">MGKDKLHVNVVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAELGKSSFKYAWVLDKLKAERERGITIDIALWKFETPKYQVTVIDAPGHRDFIKNMITGTSQADCAILIIATGVGEFEAGISKEGQTREHALLAFTLGVRQLIVACNKMDTCKYSEDRFNEIVKEASGFIKKVGYNPKAVAFVPISGWHGDNMLEESANMPWYKGWVKETKAGQVKGKTLLDAIDAIEPPSRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGIIKAGMVVTFAPANVTTEVKSVEMHHEQIPEGQPGDNVGFNVKNVSIKDIRRGNVCGDTKQDPPKEAASFNAQVIVLNHPGQIGAGYTPVLDCHTAHIACKFAELVEKIDRRTGKVMEANPKFVKSGDAAIVKLVSQKPICVESYTEYPPLGRFAVRDMRQTVAVGVIKSVEKTDGKGGKVTKAAEKAGAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8KZY1</accession>
    <name>A0AAJ8KZY1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_100720</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058362.1">
        <property type="nucleotide sequence ID" value="XM_070202261.1"/>
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    <dbReference type="GeneID" id="30168976"/>
    <dbReference type="KEGG" id="kpin:30168976"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="CAMK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF12">
        <property type="entry name" value="TRNA (CYTIDINE(32)_GUANOSINE(34)-2'-O)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="747"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="334"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="421"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="535"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="643"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="679"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1116"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="423"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="569"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="708"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1116"/>
            <end position="1129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC66813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1169" mass="128539" checksum="55C7285729B783E7" modified="2024-07-24" version="1">MPSSKSSKSSIDHRDVYYRLGKSAGYRARSAYKLIHLDEEFDLFSGVETAVDLCAAPGSWSQVLSQRLKPSISENGRKIVSIDLQPMARLPNITILQTDITLPSTIPLVLDALGGRKADLVVCDGAPDVTGVHDLDAYLHSQLLLAAITLSLTLLAPHSTLIFKIFLSPLDPHAALLASQLRCFFLGPKQDEGDYEEFDEAEEASLYAEKEEGPDRMDATGPNVGKDGYDLRGRRGGVWVRKPRSSRKGSGEAFIICRNFSPIRVPLPQTFSSSALAELRQQTSGTLTLDSLASLGNDEEQGSAEWEMIKAYVGGGDLNPIGVLPTPAKPLITTAPPITFQRPPSSPSNKHEQLSTSPKALFAHPTPLEGPSEYFTPKTSPGSPSPARRTVEPPILLSPERFRLDSGRLAGPAARAAALAYGSNDSGETSSRQSSLDSITPNPSPIHLSDPSRPWASSSHDPTSTSYAGSSKLSVPGPIPSYRDRSSSNASVLSNFSAKEDYLAATTPLVSPSLSSSSKTDLFFASSLKDSLPIPPRALPNAAKLGRGLPSGISKNEDRSTSMPTNRPSAHDRMKDSQNDRTSIWAESSSSASASNSAIDSIDLTSPFPSNQGYSDFGLPIQSGDLSRKLGFEEITSTSRLRSLSNPTATKSIPISPSTNYSPATSRFMKGHTSTLDEPLATLPTLPDIKDYTTPTKGQKRPILAGHGRRESQTLEREHSQAKEGIEIEIGQIIRPEGDEQKTKTSWKLERKLGEGAFSAVWSASPLDLGTESLGYIRPGLVVGSGGKVAALKLMDRQLSLQDSRTRISFLREVEVLRHISHPSIVSYLDSFTTPTHHVLVLEQLEGGELFDLMSDEENRKRMMLPSPPTEGQWDETGEGFVRRIFSELTRAVGWLHEVGVVHRDIKLENILFTINPFKLPPTSTNSIPLNLLPCSNNQPLIKLTDFGLSRFISINSPLLQTRCGSESFAAPEIIMGKPYDGRETDSWAMGIVLYGLIFGELPFDRESNDFNQNDNNNNNQNQNQNQNEIGYKLQLNQKLKGRKRMLKIAKCEYEFPLEINLNLKKSEQVKKLIKNLIVRDSKKRLKINQIWDQEWMKFNLPGSILRPDIIDNKSNLNDNNNNNNNNNNKKIEIENENNSSSKFITRRKVLDGFLVEENDIEEVARAEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8KZZ2</accession>
    <name>A0AAJ8KZZ2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial</fullName>
            <shortName evidence="7">Glu-AdT subunit A</shortName>
            <ecNumber evidence="7">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_101466</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="7"/>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058493.1">
        <property type="nucleotide sequence ID" value="XM_070202392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8KZZ2"/>
    <dbReference type="GeneID" id="30174931"/>
    <dbReference type="KEGG" id="kpin:30174931"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF7">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="9">
        <location>
            <begin position="36"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="100"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="7">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC67557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="480" mass="51986" checksum="70206C4683714297" modified="2024-07-24" version="1">MRATRSKLQSIASSIRPRLSDNQPTPYSWINDAIPGSSSGKLAGKTIAIKENISYHASPTSCSSALLRDYNPPYTATCVQSLLAEGAHIIGQTKMDEFGMGSQTTHLPPHYTPVHNPASPRPSEPPRSAGGSSGGSAAAVAEGSCWAALGTDTGGSVRLPASYCGVVGLKPSYGMISRRGVVAYADSLDCVGVLGRDVQTVEDVFDVVSKPDKGDMTCISSSHRTNASRILEEHLPKKGIEGLRIGLPKEITQRTAPSLLNYLKKEGAIIQEISLPSIRRALPAYYVLASAEASSNLARFGGGWYGSKNDQASEGTTESGLEKRKRIRTEGFGKEVKKRLLAGTWALSADEFNNTYLKALQLRHLLRKEYQSLFRIPHPLFLNEEKNNSNEGLDIILHPTSIRTAPRLQCYDANSQNGIKEYDQDLLTVPASLAGLPSISVPYEKGSDGWPLGISLTSQWGMEGLIFKLGKVIEDWSRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L161</accession>
    <name>A0AAJ8L161_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol-4-phosphate 5-kinase</fullName>
            <ecNumber evidence="2">2.7.1.68</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">1-phosphatidylinositol 4-phosphate kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Diphosphoinositide kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">PIP5K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I206_101124</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14425"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.68"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.1.68" evidence="2"/>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058433.1">
        <property type="nucleotide sequence ID" value="XM_070202332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L161"/>
    <dbReference type="GeneID" id="30168571"/>
    <dbReference type="KEGG" id="kpin:30168571"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17303">
        <property type="entry name" value="PIPKc_PIP5K_yeast_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.800.10:FF:000009">
        <property type="entry name" value="Phosphatidylinositol 4-phosphate 5-kinase its3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
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        <property type="entry name" value="PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
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    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="13">
        <location>
            <begin position="466"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="84"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="164"/>
            <end position="238"/>
        </location>
    </feature>
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        <location>
            <begin position="276"/>
            <end position="326"/>
        </location>
    </feature>
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            <begin position="338"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="412"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="740"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="910"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="214"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="354"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="444"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="910"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="925"/>
            <end position="957"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000444"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012172"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WWC67217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="983" mass="109075" checksum="038D85F92F858669" modified="2024-07-24" version="1">MVETAAYDPHHPLSRPKAAFNGHIAQPAALAEGSKDARIREAKAKARRFDGHSDGHLNGNVDQINQFEAVKINGTSPKINPFHILSHPDSTSPLPPLPSHLQALTSDPPYQPNDSQTQYFPSQIDSSTPPVHITKVTPTTVEVTAHTPEGTHRRVIKKISSVFRKDSADPIAPRGRSPVMQGPPPSPPLSENGDLDTGSVFASETTENPNTETIDTHQSHSNHQDEKALSPVEEVPPTNGGIPPTDSPTIANAFTTEPADLGGSLISLAPPILASTRRVSSSSATSSRAGSLTMVRSGRLAPQRDLPESSTAAQSQSHIGLGLSKNLPDIPIMIDQERRGSAASAMSAPRPIRRSTNPSPVVPSSPRSPLLHSQSHLSPSPSPNPTTAIPGLEGAALASDILAQTEILRQQRLERRQKKASAQSANTAVAPPTVESGEPNEVPPKPKAEEKPKEQEARVLVGNLIGEDHVNYVLMYNMLTGIRIGVSRCQAKIKRPLTDDDYLARHKFSFDIVGNELTPSAKYDFKFKDYAPWIFRDLRDEHFHLDPADYLLSLTAKYILSELGSPGKSGSFFYFSRDYRFIIKTISHAEHKFLRSILKDYHQHIKTNPHTLLSRFYGLHRVKLPRGRKIHFVIMNNLFPPHRDVHETYDLKGSAFGREYPEEKAKTNPKAVLKDKNWVNRNRTLELGPEKRALLSEQLRRDMDFLKRVKVMDYSLLVGIHNMERGNRDNLRENQLQMFHPEVPPPRRKPSAIKQSAEASNVRKAVRRSDPKMLDVTSQLPSSDSADRRHFLFYQDEGGLRATDEANQNMDVIYYLGIIDICTPYNSLKKIEHFWKSMTEDRHTISCIDPINYGQRFLNFLQSVMRGGDKSLRPLGLEAPSRAAEDEQPVGEVEQHLPIQGQSISVAQGINQSPTRSNSEPPAPIEKESNLHNGQDRYKNDSNGDDSRQIIQEKQEPLDGEINNINPIAVDAETRGVYIGVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L1B1</accession>
    <name>A0AAJ8L1B1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamate--cysteine ligase modifier subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_102264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019159325.2"/>
    </dbReference>
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    <dbReference type="KEGG" id="kpin:30176003"/>
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        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017109">
        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035226">
        <property type="term" value="F:glutamate-cysteine ligase catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Gclm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13295">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13295:SF4">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC68339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="42599" checksum="B564C9039C552938" modified="2024-07-24" version="1">MTASSSSTAEKDIYIFTTSQIPLPIKYSHPRKPNLVIPPILHRTLHNALDGESPSILFKNSELIIPHPDELIKHDLPCTSFSNSNSFENKLNENELLDSSFSNQILDSELTIKLHLIGNPSTSSSSSLSSKDVDDDDNDNDEKVVVEEYLNWIKKSLEILEKYKGFKKEKIDNFLIGFKGIDYRGSKTIASEMFGCGSEGLENPNTQIISNKLEKIVLNVFNKINYFFENENKNENNTKLGSLYFTLNLLKKLKSQIKINSLDTPDCHHLPKEYTNFAKENKIQLWAGGGGEGSDPLPSIHLHNLLQEFSIKLNDLTNGEFNNSSLENLINLREDGLKFQENVEKAVQVKWVLSYTLVSKTRNVVKDKGYIVAANFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L1S2</accession>
    <name>A0AAJ8L1S2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_101456</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058490.1">
        <property type="nucleotide sequence ID" value="XM_070202389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L1S2"/>
    <dbReference type="GeneID" id="30174941"/>
    <dbReference type="KEGG" id="kpin:30174941"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032161">
        <property type="term" value="C:cleavage apparatus septin structure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000921">
        <property type="term" value="P:septin ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043934">
        <property type="term" value="P:sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000260">
        <property type="entry name" value="Cell division control 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="6">
        <location>
            <begin position="35"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC67547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="323" mass="36763" checksum="7DD9465E544FBB45" modified="2024-07-24" version="1">MATSMVSSQPEEISAASYVGFDSITRQIEHKLLKRGFQFNVMVVGQTGLGKSTLINTLFASHLIDSKGRIEPDIQPRQTTEIHALSHVIVENGVRLKLNIIDTPGYGDNVNNEGCWDPIVKYIKDQHSAYLRKELTAMRDRHIPDTRIHCCLFFINPTGHTLKPIDIAVLRKLAEVVNVVPVIAKSDSLTLEERAIFKQRVMAELQYNQIRLFPFDADELDEEELQLNDRIKEMLPFAVVGSERSVIIDGKPVRGRKNRWGVINVEDERHCEFIYLRNFLTRTHLQDLIETTAQIHYESFRSKQLLALKESSAKAQQATAVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L3N7</accession>
    <name>A0AAJ8L3N7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid/metabolite permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_102758</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058720.1">
        <property type="nucleotide sequence ID" value="XM_070202619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L3N7"/>
    <dbReference type="GeneID" id="30171482"/>
    <dbReference type="KEGG" id="kpin:30171482"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF9">
        <property type="entry name" value="AMINO-ACID PERMEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="525"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="591"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="616"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="661"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="691"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="125"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="737"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="799"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="125"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="737"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="756"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="799"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="821"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC68823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="849" mass="92092" checksum="290D6BA4B45F53DD" modified="2024-07-24" version="1">MSKLQRLLQTKSNSSSQIGPGPTPHSSRLSNSQSITSSLDEYENSRNSGSSDWESQISSTPFFPDARTPNNTAFQPGENSLLYQPYSPSSGEGDIEETYSWQERIPSDGSRPAPIPLQYNEVPSLSSIPSSVSPNSSFNSTQFLLPKPRNSNTSDPIPHSNRPIPGPLSSLSLSTSHSTDPFLITPSTEINSVTALTPPNINLPLDLSSAESNLSSSGGFSSTGTSGFIKGQDDDRDAARLRQLGYDAVLGRDYTFWSSLSISWLNIGALQGTIYAVSGCYAYGGPAMILVAWPISGIFCFCLTLTLSELASAYPVAGAMSSWAWKLARGSVGGERGWAWLMGGFVMGGHVGNMLLVIWEIVNVIAGTMAISFDYKKTPWHMFLFFIAVLLIVGSIGSTAWGRSHRFWLCSGLFGFTMWAVLCITLLATNATRHRSEDTLSKFYNTTGWSSKPYVYLLGWQFTTIASGADASAHMAEETQNPSRNVPNAMTASVILTYLLGYISIILLLLSIAPEDAATVRLHSFPFGFILTTAISKSGAITICCLMIVVLHLQVIAQLQASSRFVFALARDNAMPFSDWIRRTNESKNPVFANWLVIALCLPFACMTLGSQATLYSVLAVTACTMSYTGYIVPVGLYLFSKKNLLTEGRTTWSLGIASKPVAVIGFVFGLTIIIAQTFPGSRPVTAATMSWSPVIIAGTILICFITWRSYGAKHYSGPIKAVTKWETGMEIDLTTTLGGSRSRQSHLPRSDLPNRGSTAPQNQNSNSETDSSLKLALDPHMPSVVHTISIETGHTDLHQDFDDTNHQGEWSTIRREDGTTEWTTDSSDFTSSGGTIRSGEITPTISRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L5E6</accession>
    <name>A0AAJ8L5E6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Brg1-associated factor b</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_103137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058787.1">
        <property type="nucleotide sequence ID" value="XM_070202686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L5E6"/>
    <dbReference type="GeneID" id="30170228"/>
    <dbReference type="KEGG" id="kpin:30170228"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd13395">
        <property type="entry name" value="ASKHA_NBD_Arp4_ACTL6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000242">
        <property type="entry name" value="53 kDa brg1-associated factor b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC69200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="52185" checksum="B5CFEEC0B286F7AC" modified="2024-07-24" version="1">MVYNGDEVSALVVDFGSYTTRAGYAGEDCPRVVTPSFYGYIDTPEGESSTTNGNANAAAEGEDVVMENGGEGANGTSGKTTRKYFVGDDGVGVWRKGMEVDNFMQDGIVYDAEPASRLLNHILHDRLGVNPEEHPLMITEPAWNTTKAREQLTQMVFEGEKMPALYFGSAGVLSAFAAGKPTALVLDVGYTHSSVVPIVDGYALRAGTMRQPLGSELLISQFHSHFIKPSSTRDFPLSLASRHLISKRDPQLNPGTKANPVLRDDRMSGTTASWKKWSENGVIENWKEATTEIVNYKGFDFNTSKDLPQVLYEFPDGYHQYFGEERYRFTEMLFDPKNYFNQSVEPPANLRGISNTDHSHSLKDLVSLSQLVHDSIMACDVDVRASLLQNIVVVGNTSLTRGLIERLDVELAALMPSQKIKIHSPTIPFERKYASWVGGSVLASLGTFHQLWVTKDEYEEHGINIVHQRCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L6W2</accession>
    <name>A0AAJ8L6W2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Nucleoporin NDC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I206_104584</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
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                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
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                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
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        </source>
    </evidence>
    <sequence length="1302" mass="139676" checksum="B469B003DBE4BD09" modified="2024-07-24" version="1">MILLSSIDNQPLTPPLASPRSHFVSGTERLRRYISFDSSAASQLYFPPPVPNLELHSAAASGNVGLVHYALTHGQPVNSVLHGVLPLHAACSGGSVSVVRMLIENGADVNAPRLPRRYSDGKRGTAPSVGTAGSTPLHFAAANGHAPVVQMLLASGADANKPDKNGNTPEDLATINGHEDVVHVLHVYHHMQHQDALNDPAHSDRAEPSSPSGSTSHLPEDEDSSIHTRHTWLGSRKGKERAFSLASTTSDNAFNVKKSLEGLIRRGSKLSVGDTASEHRSIYESPRSEGSGSRPDVIPRTSTISDISSINDSDQLQSPVDLNLPGSPSPQKGNHKPLISKDDDTSGQGSPVSLSRVTSGQSSQSNGTSIVLGSPPNSAGLPPPPPRSRLNSTSSHRPTLPSILEKAVHPGQAFRAAMRYHHDKDQKGRSSPDLSNDGHQNEHESISHGGGFFRGRRKSHDTDNNSTKKHKHGLKGLFRRGAQSPPSRSPSPPMKSDNSRPLGAEEIEEGIERLKRASLDLERQNQQVVEQVNKDEIEDSGIDPRIIDAISLNDEDEPDTASQPLRPPYSAPVTKTKFFPDSPGLPPRLQQRASDTSSSSTSTPGQSYFNRPRTGSEVIAPSPLANEWAHDDDSDSSAPRAGIRRVKTEIIKSAISSSPLSPDPEASSSRASSPGHSRRRSATHSGGLPSPIFSTMTKSLNPPRIAGLGWEDEVDLRKVAASGLIKRESQRRQAEVDSEFDAEDDVYHDALSPEVELDDTRVDIQKSAEDEVENDTTTTLPSGDIANDSAPTAATGNGREDIGRQRGASIGSFTTDSSRLSTPSASFRMSTISDNPDQRNINNTTTGGTMISDSDDGRPRGKSVSSIASTTSGIGYSYTQSTSTPPTSLTTPSALSLALIGGNSGFPPVPEDEVASVTSAPMNRRTISSHAEAKEAVKRNENDILQLAQLPASLDSSRSLAEQLAAYGQNYAIERQFAEIERRSSGLTPRSEDGESFFSAQSSNRSGGSSKSSDRGARQLGTAGAMQSRALSNHLVPASSVDAPRSSLPSINNIYDKRADAYRKHMAALSAAQQPLLPPSSTRHAHKRARQRAVSAQEMWLTAGPSNQQSQDNSRPTSFTANSIMSYKTARDDEEGDLHPHISGPLPIISNPVTGQRPRKSSFGSINSATTHNHGRSHMAPSRKYHPGGSTSNNPIMDNLSARYQGLQQPSMGPPSVPRSLSNPTTSMGVSPYVSIFSNRFQPKVPLNDDDSDDENDNNREYTVIENDWRGGHIIRPDELGLSTAGGNNEKKKWSLKKLSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L8L1</accession>
    <name>A0AAJ8L8L1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_106139</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTH2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010494.2">
        <property type="nucleotide sequence ID" value="XM_019156692.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L8L1"/>
    <dbReference type="GeneID" id="30173333"/>
    <dbReference type="KEGG" id="kpin:30173333"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02430">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1490.10:FF:000003">
        <property type="entry name" value="Peptidyl-tRNA hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00283">
        <property type="entry name" value="arch_pth2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649:SF11">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="47"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC72179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="217" mass="23343" checksum="240F99B18AA76534" modified="2024-07-24" version="1">MSSIRMDSIISPIVISIIAFSAGYQLNSYLSSKSNQSLLLSSKNSFSSKKKSESSNNNNNNESESEISNESEGGTDTESDLEDTKAALSSNLNLTKFNNKEEMKLILIINDELKMTKGKIAAQAGHATLACALTLKEANPKLFRAWQNQGQPKIALRCANTEELEILAAQARSLNLCARTIRDAGRTQVAPGSKTVVGIGPGPARLINTVTGKLKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L9Q5</accession>
    <name>A0AAJ8L9Q5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_106125</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059352.1">
        <property type="nucleotide sequence ID" value="XM_070203251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L9Q5"/>
    <dbReference type="GeneID" id="30173318"/>
    <dbReference type="KEGG" id="kpin:30173318"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46156">
        <property type="entry name" value="CCCH ZINGC FINGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46156:SF1">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="235"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="318"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="235"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="318"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="23"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="410"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="411"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="456"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="469"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC72165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="484" mass="52940" checksum="8072A383C839EF87" modified="2024-07-24" version="1">MAPLTPAERQKILLQQEIAKLSGAISRRSTTAPSSSYHPYRGRSVPRGYSATRARGRGRGGSYALDLRQINKQSSSAEPSRPSSSASIHNTTKNEEKEAGELDPSPPDSDPVAGPSSTSAPHANWVKGKGKSGNMSLMTAEKRDQLKVQRQRTPKLPPQIQMIISESTSSGDKRVIIDGVVFQFEQDGKKLTRIGEAPSSTNTSTPTRRTLRFGGEKYRRTSRGNLVSRKSGSTSKSMELCRYFTKTGRCNFGLTCPHIHDPAKVTICSRYLRDTCTLGTSCPLSHTPSPHNTPSCVRFQATSTCSKPNCPYPHVKVSPDAPVCEDFARIGWCDKEAGTCENLHVWECQEFREKGTCSRNGKCGLRHVVRAETNRAVLEDTAETVPKNGEGGFEEQDSFIEFDQGSPALLSDDEEEDEEENDDDENVAEEESEGEDREDIIDVGSPSFDGNGKYTAASSPSAHPPSDMMDTDEVDEDAVLDVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L9Y9</accession>
    <name>A0AAJ8L9Y9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_106277</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059385.1">
        <property type="nucleotide sequence ID" value="XM_070203284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L9Y9"/>
    <dbReference type="GeneID" id="30173472"/>
    <dbReference type="KEGG" id="kpin:30173472"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF39">
        <property type="entry name" value="TRANSPORTER LIZ1_SEO1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC72315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="57471" checksum="DE3F4E28629339D7" modified="2024-07-24" version="1">MATIETDLPPPTVLLDADRQSYVGKPASKKGKWQKFVSFIWDSDYYEKSDAERNLVFKLDCFMLTAMTIGWWLKNLDQNNLSNAYVSGMKEDLKIQANQYTYMGTIYNAVVAAMQIPSSFIVMKVRPSWFLAACEIGWGIFTFAQAGAQSYQAMYGFRFCIAIFESFYYPIGFFILGSWYTRPELAKRIGLWFVAGPAGSAFSGFLQAAIYKNLDGLHGLAGWRWLYIICGIMTVPCGVTLFFLVPDFPENTKVWYLSEEEKVLAKERVARGGAQPMKGNINGQVILSALKDWKFWILVPFYCIYGFAVQNGTQFGVYLKAYKYSVTLRNVLPSLMYIIQIPCILIYCYISDRTTRISRGWIMLGPLIWGIFPTAVLAFWPNSNPLRVFAFMVNGSLYITPVFYAWVAEMCGHKTELRAFITGSTSCLFYAFNAWLPAIVFLQTDGPRFKKGFRTTFSCCIVSVVFVLIIIVLRRREVKKEKNEMISDQAPITPEREGDIEEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LCC9</accession>
    <name>A0AAJ8LCC9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP synthase subunit beta</fullName>
            <ecNumber evidence="14">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I206_106949</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="14"/>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC72985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009946.2">
        <property type="nucleotide sequence ID" value="XM_019157228.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LCC9"/>
    <dbReference type="GeneID" id="30173877"/>
    <dbReference type="KEGG" id="kpin:30173877"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18115">
        <property type="entry name" value="ATP-synt_F1_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01133">
        <property type="entry name" value="F1-ATPase_beta_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.170:FF:000004">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000026">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050053">
        <property type="entry name" value="ATPase_alpha/beta_chains"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184">
        <property type="entry name" value="ATP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184:SF71">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 14" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 14" id="KW-0139">CF(1)</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="217"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="WWC72985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="415" mass="43926" checksum="50D96BC254CCD222" modified="2024-07-24" version="1">MTLVSRSAIRLSRRGGQQLRNARANAAFFTTAANQASNVLPKFAASSSRVQVPKTSVNSTRTYATPSNLQTGAIKTVIGAVVDVHFDSDNLPPILNALDVQFAEGQEKPEGGRLVLEVAQHLGENTVRCIAMDGTGGLVRGQKVVDTGAPIKIPVGPATLGRIMNVIGQPIDQRGPIKGVKEAPIHADAPEFVDQSTQAEVLETGIKVVDLLAPYARGGKIGLFGGAGVGKTVLIQELINNIAKAHGGYSVFTGVGERTREGNDLYHEMRETGVINLEGDSKVALVFGQMNEPPGARARVALTGLTIAEYFRDEEGQDVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLSTDMGGMQERITTTKKGSITSVQAVYVPADDLTDPAPATTFAHLDATTVLSRSIAELGIYPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MLK1</accession>
    <name>A0AAJ8MLK1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7721 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_101855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="30175423"/>
    <dbReference type="KEGG" id="kpin:30175423"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056138">
        <property type="entry name" value="DUF7721"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39477:SF1">
        <property type="entry name" value="BETA-FLANKING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39477">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24845">
        <property type="entry name" value="DUF7721"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7721" evidence="2">
        <location>
            <begin position="129"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
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        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF24845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC67936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="291" mass="30378" checksum="E57047E7AD468436" modified="2024-07-24" version="1">MDFIKKMAQEKLQGMGDNDNDNQQQGYSNQQQGYGQQQGYGQQQEGYGQQQGYGQQEGYGQQERYNNQQEGYGQQQGNYEQQGSYGGNEGGYAGDNQNFGQTGGAQYNAPHGEGGASYGSGSGAPIINQNAAIDAANQHASNGSENSSLFSTAMGFLGNMNKNDDDVDEQKVQEQHQQAYSQGNASGMSANAIGSAAAMQALKQFTSGNSNAADKSSGGDMQSKIIGMAMSEAAKLFDQSGGAAQGDKQDAVTSAGQTIMKLMLKSQFSGMTGGGNSGGLGSLMGMASKFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MMU4</accession>
    <name>A0AAJ8MMU4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_100814</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058382.1">
        <property type="nucleotide sequence ID" value="XM_070202281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MMU4"/>
    <dbReference type="GeneID" id="30168882"/>
    <dbReference type="KEGG" id="kpin:30168882"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="TBC1 domain family member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000031">
        <property type="entry name" value="TBC1 domain family member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF337">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
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    </dbReference>
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        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="144"/>
            <end position="349"/>
        </location>
    </feature>
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            <end position="141"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="458"/>
        </location>
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            <end position="856"/>
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        <location>
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        </location>
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        <location>
            <begin position="734"/>
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        </location>
    </feature>
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        <location>
            <begin position="796"/>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC66907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="856" mass="93731" checksum="6E3431324635D5DA" modified="2024-07-24" version="1">MAEAIREEVVFPRPSIAEIQLTWKGIFSDPLISPSRLKATALTKNGLGEAAADGGIILRSVYWRLYHNLLPPPSSPNLFSGSVSIAREAYNSLRRRYLIAPDGRWASDCTGSETHLAPTSSSSSRSAQVSGSHSAQGDGWDPLSLDSSSPWKTWFAYVDLRSTISQDVERTFPDIPYFQLERVRKSLVTSLFLFSILNPDVGYRQGMHELLACCFLAVDRDSLSSEDRIENDMQTEAMWDTLDRNFVEHDSFQLFQAIMKGAKEFYEWRAEEGPIKSRTPNAPPAPIITRCNNIHTSLLRRIDPQLWERLETEGVEAQIWAIRWIRLIFTREIPFPSAMRIWDGIFAEDPGLGIMDFICVAMLLLIRNELIEADYPTLLTQLLHYPSPSGIYPFEPSLILSQALFLRDNISPTAGVEVVLQNQDLLSVKVNPSDRVAEDHPVPRRGRGGISYRGSARGGRGRAGMGGLAQGLFERAQAAGLDKAFMTTVADLRKNLPDSATAYSYLPNLPFSPGTPSKENGSFSSIPSSSAALPRSFLTSPSATYFQQPQAVPQAAALPQEQAIRPKIGGRPSADSIGTEQSLKDAELEMAELRLAMVGMGKAMSEWLLALQPSIERDTGESEKENAWKGLERVKDGLLDAAGKETDQIVREWGWGLETSSSRAGTPAPDPEPYHPAESLVLTDNHAQTNDVGQNEKGTLEFEDNTTPTLPSHSIMSTQPAFPSPSISTTTSSFRLNNDASSSVLPRNPTSTIQNPDKSNLTLSSARSTPSAGLFRTPTEPNTAPLPPRPLSASPINQYTTTAVNSSQRQDPSANKRTTDGDRVNGDPLAGLGVTNRDTKDRRSGGVDPLLGVGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MQS0</accession>
    <name>A0AAJ8MQS0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipid:diacylglycerol acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_103911</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC69967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058954.1">
        <property type="nucleotide sequence ID" value="XM_070202853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MQS0"/>
    <dbReference type="GeneID" id="30172885"/>
    <dbReference type="KEGG" id="kpin:30172885"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="569"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC69967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="728" mass="81917" checksum="A162C210CC3C3791" modified="2024-07-24" version="1">MPRTRSEMKEDDEIDIKITPPTTSSPSTKVKTTTTKKTPKIRTPPPSGLRQRIKNTVDEISKDAEELHVRLKKKDDGHYKLLAPGTPFNEIDLSESTFFRHGDHLKRKTWKSWLFGRKFFFPAGVILGVCLALWAVDLTGLPADMKDIWTTLPAALDPRDLLANLTVVEGARKALENRDFTVGESLVEQYGLHKHHPIILIPGIVSTGLESWGTETVARSFFRKRLWGTSTMIRAVLTNKERWIQALSIDPETGLDPPGFKIRAAQGLDAASEFIQGYWIWQKIVENLATLGYDTNSMDMAAYDWRLAYYNLETRDAYFTRLKYKIEVMRRHNGQKVVLCSHSLKWVESNPEENGFGGGGGAAWVEENIDSWVNVAGTMLGVSKAMTAFLSGEMRDTVELHPAGSWVLEKFFSRRERAKLFRRWPGSTSMWMKGGNRMWGNHSAAPDDPENATDTHGRFFSFRHPGTSEKEETLTKWTVSPNLTLNEAGPYVLTHTPPNFQRMMESNYSVGFEGNVEQLKKNDRDHTKWSNPLEVRLPEAPSMKIYCLYGHGKETERSYWYMQGEYEQDDSRSDAENEDAFCDSSDPSNGCDNSTSLRVPLDFPLSRKHWIDSAVSVKGSKPEVRSGVKFGDGDGTIPVVSLGSMCLKGWNGTTKWNPAGIPVVTQEYLHSPESLDLRGGAQTADHVDILGATPLNTAILKIAAGRGDLITQQIGSKIFEYIKKQDWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MRG2</accession>
    <name>A0AAJ8MRG2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_105694</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059271.1">
        <property type="nucleotide sequence ID" value="XM_070203170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MRG2"/>
    <dbReference type="GeneID" id="30171772"/>
    <dbReference type="KEGG" id="kpin:30171772"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000409">
        <property type="entry name" value="CMGC/SRPK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000541">
        <property type="entry name" value="CMGC/SRPK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000076">
        <property type="entry name" value="CMGC/SRPK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="81"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="343"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="667"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="374"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="390"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="410"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="454"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC71736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="710" mass="76719" checksum="08599E89A72D34ED" modified="2024-07-24" version="1">MAPHASAGGSSGDSRAAPTPLAVPSPAPQPSTSASAGNSLSVSQASQTTSVLTEDEEDLEDYRPGGYHPVNIGDEFNNGRYMIVRKLGWGHFSTVWLARDDHTKRHVALKVVKSDGHYTETALDEIQLLQRVVNSSQTHAGRCHVVGLVDNFRHTGPNGSHVCMVFEVLGENLLGLIKRYQHRGVPQHIVKQIAKQVLLGLDYLHQECRIIHTDLKPENVLICIEDVESVVQAELASCPAAVPTKLVGVPPSQGRLGNQTPRKDGLFIVGSQPLPSPSSSYSSSPMLDKYGFGMSKISGVDAFPKTNSVAGGSNVNKGTTAEAIGDGIGNVKLGESGLVWEKTKAPVPPTSGPSLLSQQMSAAPSSPPLPPTNLPASSSTNPSTTATPSQTVISTPATTPDSSRNDDAKISTSVMSTESLSPPKQPQPTKINSVSTAGFTTSPATSHINNLQDQEAHHDPDDPNRDAPVAGDPNHLPPPFPYDPVSLERITVKIADLGNACWVDHHFTNDIQTRQYRCPEIILGTRWNQSVDIWSAACLFFELLTGDYLFDPQPGVKYDKDDDHVAQIMELLGEMPRSLALSGKYSHEMFNRRGELRHISRLRFWPMISVLKEKYLMEHSDAELLSSFLMPMLHYYPDSRATAAELVNHPWLDGVVVQGELEMAHNRHQSEVAQSSEAGKSGESRGPPVPLQDVLGLGPSVKGMVGMGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MRI0</accession>
    <name>A0AAJ8MRI0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_104956</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC71003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_070203038.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="kpin:30170864"/>
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        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="STKc_AMPK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="50"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="307"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="612"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="701"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="353"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="437"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="612"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="714"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="727"/>
            <end position="738"/>
        </location>
    </feature>
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        <location>
            <begin position="751"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="769"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="817"/>
            <end position="838"/>
        </location>
    </feature>
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            <end position="886"/>
        </location>
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            <begin position="978"/>
            <end position="990"/>
        </location>
    </feature>
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            <begin position="1033"/>
            <end position="1043"/>
        </location>
    </feature>
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        <location>
            <begin position="1097"/>
            <end position="1108"/>
        </location>
    </feature>
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        <location>
            <begin position="1144"/>
            <end position="1163"/>
        </location>
    </feature>
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        <location>
            <begin position="1169"/>
            <end position="1180"/>
        </location>
    </feature>
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        <location>
            <begin position="1181"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1197"/>
            <end position="1214"/>
        </location>
    </feature>
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        <location>
            <begin position="1235"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC71003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1292" mass="141640" checksum="52B51FB8E5D4F547" modified="2024-07-24" version="1">MAAPRRGGGQNNFTSYSANSANNKQAQLTNAYQELAKELGTDKLKVVGGYTLGRVIGEGTYGSVHLATHRLSGTRCAIKKIPKSFTPHLTREIHHHRRLHHPSIVHLHEIIATENNIWLVTELCSGGELFDYLVERGRMLEGEARKLFGELVVAVGWMHRQGVVHRDLKLENVLLDGELRIKLGDLGFVREWQRGRLMETFCGTTGYASPEMLAGRKYLGVETDIWSMGIILYTLLCGGLPFDDDDERVMKELIMKGEYDEPEWLSEEARSLIRSMLQQEPSQRITVEGIFEHPWFKMTLVDRIQGHAGDSHSIPPSPLPDGPASGDELFSEPFNKSATTGSLHLTPHLAQPSPLSTNVPTVPNNDSEPSEPSVAGSETGKAESTDTTPPTTAEEDDGEEMGPPFHRVNSSEFSATEKALELLHPNSSQSTIRRPASISPKSSSQYKSKVARRSTLEGQKEEDEEGSDVAASLPTPDDHSLHLPLAQHSRTPSRTKRRSVSSTMSVERRHSHHSMSGQWQRYLPEDYLAKLNETPSPPFTTSSEKYLLNQLNDMGMDIGQLKHSVENDACDSSAAMWWILRAKQADRGETNEVIEARETSAAKKREKLAHYAREERRKAREAAKEQSQGITEDSSDSRFPAAVTFKDGAASIPVTPSFTIMDLGAPISGTGQPVFASPDVLPVSSDTSAIDALNAVKTPQFELRPLPGTLAPNTAPPTTPPRDPPLRDLLSSPDASPARADDDRTTKRRSPSMSMLQRATSAWVGVSGKKNEEKERAETDSPASHKDEKRSTSPSKLLKPPPRPKHLPRPDGDHDAASSSHPTPASTPPASGTPLTTPQREKQSTLGKSAGQNTGGAVDLTEEMTASTSGNSITADQLVAGSSKQPKGNKRDSLWTTFRHLFNEDKRRRKRDIPGSPLAGSETKVPPSVVLTRGPNGRVPHINRTPVSLPPGSRRTSLDGRPAMHSRRSSSISNSRRSSFDGHVMHETHDLGGLYRRTSQRSHGSQTPTSDREYIDFPSRPGSAHSVQRGNSRRSSMSMRSPSLVSDHASGRFKSGQPASPLHNYRRRAPGGSDSSRVRHYRVIHENQALRPSSVTSSIKSNASSRASSVERKRDTDREDDSGRDDTASLRSQRRKRSEGGSGKNSSLAQQIHRTRSPLSASQPAKKGPTRDVFQKKQDDDWISEEEDEFAGGLGQIGNTSSSNSGQRWLNGTRASAYPGLKFSNPSTKRKERGRRTSLEEKHDKLEEDGRTGLGIGMEGPPGSTNSGRARRGLPPGRSAATVIEEEEEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MRS5</accession>
    <name>A0AAJ8MRS5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_105467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_070203126.1"/>
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    <dbReference type="GeneID" id="96955760"/>
    <dbReference type="KEGG" id="kpin:96955760"/>
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        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="134"/>
        </location>
    </feature>
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        <location>
            <begin position="153"/>
            <end position="206"/>
        </location>
    </feature>
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        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC71509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="22009" checksum="DE0915B06F86E1F0" modified="2024-07-24" version="1">MRPKEHVLSQQVLEFLIEHQDHFLLGMELKPKKQRKEKAPVPQPPPLVKADSDLMLPSDSDDEAPAGGYYVIEGPGRPTSPASPSSQPSSSLPNISANLLPSPPVKSKIVPSDLMEMSESDEEAPPGGYEVRTGDPASARAALLAKAHLLNQAPTVQRPTSNQAPIRSAALPTVASGSTLARRRTVPSRAPGEAVPRTRRSTKEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MS56</accession>
    <name>A0AAJ8MS56_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_106418</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12 13">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_070203316.1"/>
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    <dbReference type="KEGG" id="kpin:30175591"/>
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        <property type="component" value="Chromosome 9"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="995"/>
            <end position="1346"/>
        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
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            <end position="200"/>
        </location>
    </feature>
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        </location>
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            <begin position="284"/>
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        </location>
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        </location>
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        </location>
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            <dbReference type="ARBA" id="ARBA00022807"/>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50235"/>
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        <source>
            <dbReference type="EMBL" id="WWC72456.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1348" mass="147643" checksum="4554F45A5EEBAB17" modified="2024-07-24" version="1">MSRSTSLTSVPLTDLQSMASYDEDIQSRSPKEWFDRAKHEADLAILAERSNRKEEMFLAYTRSCQAYSYCKMHPGLKDLKKSDSHWNERVKDFKETYEAFLGKAKDIKEQLKKRDVETNGASSSRPGPSRSESGPDIRGGGSIADRLKALGGQGMDVGNPTKRFGKDLPSPTVSSNRPSAAPANHIHVSATSAQPSSTGASAGGNLGSLRTTKPAGTRQRSGSGASLHSLTPSGTSSAPSAKPPTIQESGSAATVRPSATGSSTRSRRNTNPTEGDRPLPVAPINNNSQTSLNHPPPAASTSKPPLPPIPSTLTSRKLVAQSQPNNEADTSSGTLKDFEKAFPSLSEFGKQFQDDDEDLVKANARIAQWSSSIQSSKHSEKSGQPNGSVNGLAKFTQHNPTIEENGEHSPEIHLPDVPSFPTLPSAPIERPGRSSSPLPPPPQRPDSINALERIESGHGDVKKALSPPMPDAGAGLKRPASTPNVATLPGDVDLLSDEPIIEDEKDKHPSRPSAPVLPASKPNNLPNGVVKDNAPNGVTRDTAPTAGLRDLVSPTLSFPVATPTPPQNSPHTRHSLPHPPSMTPRPPTSQPNGLTHSQDFKKPKFPFSNSVTPDELRSYFLNPAVDILLLDVRAEEEYKRGYVGREYEPRGAKITVVWMDPTVLMRDGINSQKLEDSLSLSPPAQQKAFASRHTYDLLVVYDSKSTNWPTKEQKATPASRLWESIYQYEFTAKKLERTPVMLVGGYEAWREFIKMRASKHQQAYAAQLAQSHGNGNGHGHSQSVQVNGQSRPYNPKTNGYTHSSSTSRLDRVTSPSSSVDLSKRANRDMPVYQSAPYAKNITDSFGHAPQSMTGEPSSYISGQPSRSYAPSPISHTRSPSNYSSSATPITAPPQASIHPGPGARRRSDYLDQHGQAYSGSALTTAPSPRPAVDYPQAHALSSANLAQPPPAAINPMDRYDTRPAVVRSGSIRGLDLVAREGDEVRYWNDVVLGLTGLKNLGNTCYMNSTLQCLSATYPFTSIFLDGSYKRSINMNNKLGTQGNLANAFAELLKALWKEDYTFLSPVTFRKNIITFAAQFSGTDQHDSQEFLSFVLDGLHEDLNRVKIKPPPVDMSPEREAALETLPPAVASEKEWQIYKMRNDSFIVDLFQGQYRNRLECLTCHKTSTTYDTFMYMSLPVPSGKSKVVIQELIDEFVKAEVMEKEDAWNCPRCKVPRKATKTLTISRLPPVLLIQLKRFTTQNGVFWDKSETPVIFPVKSLDLTRYVPIRQPTGNEDLDDPRCQIGPFKYDLYGVSNHMGTLSSGHYTAYVKSSKGWMYCEDSKISKAHEKDVVSRPAYILFYKRIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MSN6</accession>
    <name>A0AAJ8MSN6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">40S ribosomal protein S23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_106195</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
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        <property type="protein sequence ID" value="WWC72233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019156746.2"/>
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    <dbReference type="GeneID" id="30173389"/>
    <dbReference type="KEGG" id="kpin:30173389"/>
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        <property type="component" value="Chromosome 8"/>
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        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="40S ribosomal protein S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NA-bd_OB-fold"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC72233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="145" mass="16036" checksum="FBB37975B8A1BA64" modified="2024-07-24" version="1">MGSNKPRGLQAARKLRTSRRENRWADKNYKKRALGKFYKTSPTGGSSHAKGIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKVTAFVPNDGCLNFTDENDEVLISGFGRRGKAKGDIPGVRFKVVKVSGVGLLALWKEKKEKPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MST6</accession>
    <name>A0AAJ8MST6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Exocyst complex component Sec10-like alpha-helical bundle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_106057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HSK1</accession>
    <name>A0A1B9HSK1_9TREE</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">I206_103781</name>
    </gene>
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        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700118">
        <property type="protein sequence ID" value="OCF46253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC69838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007472.1">
        <property type="nucleotide sequence ID" value="XM_019159420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HSK1"/>
    <dbReference type="STRING" id="1296096.A0A1B9HSK1"/>
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    <dbReference type="KEGG" id="kpin:30176099"/>
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        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF46253.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC69838.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HSX9</accession>
    <name>A0A1B9HSX9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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        <name evidence="8" type="ORF">I206_102243</name>
    </gene>
    <organism evidence="7">
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        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
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<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HT65</accession>
    <name>A0A1B9HT65_9TREE</name>
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            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">CBS 10737</strain>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
                <person name="Sun S."/>
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                <person name="Sun S."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
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                <person name="Heitman J."/>
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                <person name="Young S.K."/>
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                <person name="Imamovic A."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
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                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="Zeng Q."/>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
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                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF46638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC72654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="312" mass="34829" checksum="C718FF6FEBD11E3C" modified="2016-11-02" version="1">MSNSYVQALIPKIKAILEGSDLSTVSAKAVRKQLVAAGEDEATIKASRGAIDEEISTIYDQLTSAAPPSPPSSEDVPLHPKAEPGSSQPRPLQTFIKREVKPSVSIDEDDEETDEQMARRLQSEFNDQASSSRPRRANATAPAKKKKKTTKKRISRASVGGSEEENGVTKKKRKVNPDNPFNREMILSDALADLVSAPRLSRPQVVKQIWAYVKENGFQDQTDKRYILCDEKLKKVFHTDRLHMFTMNKILVDHLRNPDDVIFKAESKDGIKKEVQSNIIPTSIPIPAAPAIQSTQYISEEEDEDESEDENY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HTQ2</accession>
    <name>A0A1B9HTQ2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent DNA helicase PIF1</fullName>
            <ecNumber evidence="14">5.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">DNA 5'-3' helicase PIF1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">DNA repair and recombination helicase PIF1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">PIF1</name>
        <name evidence="17" type="ORF">I206_07493</name>
        <name evidence="18" type="ORF">I206_106616</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the helicase family. PIF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="14"/>
    <dbReference type="EMBL" id="KI894016">
        <property type="protein sequence ID" value="OCF46640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007859.1">
        <property type="nucleotide sequence ID" value="XM_019159187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HTQ2"/>
    <dbReference type="STRING" id="1296096.A0A1B9HTQ2"/>
    <dbReference type="GeneID" id="30175862"/>
    <dbReference type="KEGG" id="kpin:30175862"/>
    <dbReference type="OrthoDB" id="432234at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18037">
        <property type="entry name" value="DEXSc_Pif1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001226">
        <property type="entry name" value="ATP-dependent DNA helicase PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03176">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048293">
        <property type="entry name" value="PIF1_RRM3_pfh1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF5">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 14 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="247"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="DNA-binding region" evidence="14">
        <location>
            <begin position="660"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="58"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="79"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="255"/>
            <end position="262"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OCF46640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="WWC72652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="702" mass="76930" checksum="A763FE4A3E66134B" modified="2016-11-02" version="1">MPSLLTSRTSSNASSSSGSRLNNGFSRVTSFKRHFEEDEDDDFPVVVSNPGLKGTAEVVDVDAGRSTNADISKVNGKLRSLSSASPQPRPSSSSSTTFRTSTATAKSTSIAKTTAASTGETPAERRRKAILAAMSQNTEPLSTKPDLPPKRSEPILPGLSSNLNNADFISANTQMRDLAKPVVRQELPSLPSLPKRALPWEEEHTTSKRSMSRTSSAGKSGGLALNIKQKVTLSAEQQKVMSLVVAEGKNIFFTGSAGTGKSVLLRELITSLRKKFSTAPDAVAITASTGIAACNIGGVTLHSFGGVGLALEDPKILVGKLRKNKKAAARWQRTKVLIIDEVSMVDGGMFDRFCKVAQMIRKNPKPWGGIQIVVTGDFFQLPPVTKGGSMPKFAFEADMWDETIDLSVNLSKVFRQKDPRFVDMLNEMRFGKMTKQSVEAFRCLAREVPYRDNIEPTELFPRREDVDRSNSTRLNQLNTDGYSYTSADGGVISDPVQKEKLLANFMAPKFLELKVDAQVMLIKNMDETLVNGSMGRVVGFCHKPFYTTDTTGKWAPDADLEDLDEEERYKRQKLRDTFQEKVASGTVKPSPVVRFNVPGGTRDLLVEAEPFKVELPNGEVQASRTQLPLILAWAMSIHKSQGQTLERVKVDLGKVFEKGQAYVALSRATSLDGLQVLGFNPDKVMAHRKVAQWSSQLKDLNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HTU3</accession>
    <name>A0A1B9HTU3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleoside-diphosphate-sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_07540</name>
        <name evidence="5" type="ORF">I206_106569</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894016">
        <property type="protein sequence ID" value="OCF46685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007904.1">
        <property type="nucleotide sequence ID" value="XM_019159232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HTU3"/>
    <dbReference type="STRING" id="1296096.A0A1B9HTU3"/>
    <dbReference type="GeneID" id="30175909"/>
    <dbReference type="KEGG" id="kpin:30175909"/>
    <dbReference type="OrthoDB" id="16464at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd05238">
        <property type="entry name" value="Gne_like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
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    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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        <property type="entry name" value="ADP-L-GLYCERO-D-MANNO-HEPTOSE-6-EPIMERASE"/>
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        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATE-SUGAR EPIMERASE"/>
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    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
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    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="15"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF46685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC72607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="347" mass="37415" checksum="CE97D2E97E4CA818" modified="2016-11-02" version="1">MVDANSNGTSQSNVVLITGAAGWLGGILANELLSDPKTPNVHLILADIVEPKAPKGAQHALTFKADLTNPESIAKLYDTEFGTPDTVYCFHGIMSRGSEDNFDLGLKVNIDSIRFMLEAARQRKTNSGGLIKFIFTSSLAVYGGPLPHVVDINTIATPEGAYGMGKLSSELLVNEYSRRGFVDGRILRLPTIVVRPGVPSAATSAFISGIIREPLHGEKAICPVGDGFDSPELELAAWVASPEITIQNFVIAKHIPKEKFLAHTRVAYLPGFTTTVREELEALATVAGKDALKLVTFKDDPTNRRIVSSWPARFNNEYPLSLGFVVDQGGMVPIVQRFKDAVEAGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HU44</accession>
    <name>A0A1B9HU44_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_07175</name>
        <name evidence="10" type="ORF">I206_106372</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894015">
        <property type="protein sequence ID" value="OCF46788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008007.1">
        <property type="nucleotide sequence ID" value="XM_019158869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HU44"/>
    <dbReference type="GeneID" id="30175544"/>
    <dbReference type="KEGG" id="kpin:30175544"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF39">
        <property type="entry name" value="TRANSPORTER LIZ1_SEO1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="475"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCF46788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC72410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="497" mass="56895" checksum="25CD12A948588158" modified="2016-11-02" version="1">MSLQPKKEYESSQRPKIPWYYYLWDSFGKEPAERRLLVRLDLSLLVFSTLGLIMRYIDQTNLSTAFVSGMKEELSMFGLEYNYCNTAWSVGYVIGQIPGNILLNKVSPHYIVFGLEIGWSIMTLCTTWVKNWHQLCFIRFMVGLFESAYYPGLLFLIGSWYTKDELGKRSNIFQAATAGGTLISGVMQAGIYKTLNGKHGMAGWRWIFTIDAIISIPIAISAFFLIPDLPWDIKPNWIFKQKDIDLARKRLTIAKRQGPQKGGLNKKLIWNIISTWHIWVFTFVYSCYIFSQNPQQSMSFWLKYSKDPKYSVEQINYYPCGIWSTQIVSALGFAWISDNLLKGRRWPPLLLVALWHCIDCALLAGLPVYPDNRAGRWVLYYLSGIVNCTPGLLYAWCSEIIGESSEKRGIVMGTFNSVAFSFNAWLPLLLFKQTEQPTVHKGNIAASVATALQFLGILGILYLSTRDFNRQVQEESFDEGLQTPGEIEDVDRKERSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HUE9</accession>
    <name>A0A1B9HUE9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome assembly protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_07281</name>
        <name evidence="11" type="ORF">I206_106476</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
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        <text evidence="1">Required for efficient biogenesis of the 60S ribosomal subunit.</text>
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        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RSA3 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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            <dbReference type="Pfam" id="PF14615"/>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
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    <protein>
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            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">I206_106502</name>
    </gene>
    <organism evidence="3">
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        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 10737</strain>
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    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894015">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC72540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="AlphaFoldDB" id="A0A1B9HUI2"/>
    <dbReference type="STRING" id="1296096.A0A1B9HUI2"/>
    <dbReference type="GeneID" id="30175676"/>
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    <dbReference type="Proteomes" id="UP000094020">
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="174"/>
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        </location>
    </feature>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1005"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1064"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1083"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1137"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1152"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1168"/>
            <end position="1186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF46920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC72540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1270" mass="141600" checksum="4EB39987991D74DE" modified="2016-11-02" version="1">MCESIPSVTLYGTTQLTTTLTTSTIITTQLSQQIKLLTSQIITKEIITSIIPQKTLYYPCSETEIIKPSSTSKQLLQTTLSSNLNENSIDLNATGQFTGSLPTQIKFTSKSSSFTSSLVKSSVVTSKSSSQLTTSTSTLTQLPLITSSRSDNVTNVNSSAEESNTTTKSNAGTIAGGVIGGIFALIIFIILLMCCQKRRARRRIKGGSWRDSSITPFHGGQSGNDYWEKRFREIESANSSRGNELGTNRINETEKGDWDSQTSKKLRLTLDLGSKDLPSRPPSRLSMISSFFGGRMTPTPNITSSFHHSRNGSTPTLRSTMPKTSKNRFSFNPFKRNNNTNNNYYYYNKNQFNNHNQDFNKSQISLPKQNHQHNRSISSPWIQEDSKSFKSGSGTNSNGIKSAGYSNSIKSPKARPSLEDNLNINRNTSVKLNNNNNNNNNNVDKRRSQNTFGKKLSSFDLPITKEEEKELSRNSENNVVEINRNEMINVNNWNYQTQNNNLQLPRQAAMAVNSINSANGSGLNPIREGKVIESPTEEEIEERRNMEWIRHSNFQSDHGEGTETLDLTNEEKLKELNKQLGLDDLNELSDNSIINYNFQNLDNSNLNGLQTQPKTYLGFNQVNDFIGNTPPQLGVIGTYTSLSSNSHLSNISSITSLPPTKKNYNSGISSSSFIPFVPLPKLGQTINNNNNNNHLSGISSNGSNNLPFIPPIRGGHGSISGSGISNNIPSTILPRGYLSGLSSAYSNSYSNSYNNNQKNLKPRSPDSISIPSDIIIDSPPKMYQTGVNLQNNKNNNDSNCLNRYNSQSTISSYSNHPVSPYSSQPSFGVSRPNSQLSDTNITGNRNTRILTIYKVEKERNSRKAFIYSSPSKRRSSLNNLKRTYSGKLINTRDSLPPPLPNQNRKSAFDDADEEALGLSFNNNNRIPISNHTLKNSSPPPNSFVFNNDNLIRRSLKNQRESKGKYVPTIRLSQRALTPSFWIDEELLARFANNDDDDDDNGNDNTFVTSSTDGGSTIKPLKRKSKSLRSLEENHEAMNLDNSQEYEIEHNKNVQLERQSIATIRHQPSMTVTRINKEEKSSLPAYSTTPRRNSHASMSISSKDEYSSSTMIYQNENNLSRSDSNIKLKANKDEASISYSPIPNITPPNSSSVQPDNLNLNPSSLTPKPEPKKQERKQEKGKGKQKEIEIEKEIQDENENEILSPNTPTNKLNLLNPCFPKLPISPTNTSSSSSLISDCSSSKLSNNWEFQNNNNINQNFRFSIKQRKKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HUL9</accession>
    <name>A0A1B9HUL9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease T2</fullName>
            <ecNumber evidence="2">4.6.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_06735</name>
        <name evidence="6" type="ORF">I206_102170</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the RNase T2 family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.19" evidence="2"/>
    <dbReference type="EMBL" id="KV700117">
        <property type="protein sequence ID" value="OCF46961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC68247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008180.1">
        <property type="nucleotide sequence ID" value="XM_019158434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HUL9"/>
    <dbReference type="STRING" id="1296096.A0A1B9HUL9"/>
    <dbReference type="GeneID" id="30175104"/>
    <dbReference type="KEGG" id="kpin:30175104"/>
    <dbReference type="OrthoDB" id="435754at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018188">
        <property type="entry name" value="RNase_T2_His_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033130">
        <property type="entry name" value="RNase_T2_His_AS_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240:SF17">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="Ribonuclease Rh-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00530">
        <property type="entry name" value="RNASE_T2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00531">
        <property type="entry name" value="RNASE_T2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628122" description="ribonuclease T2" evidence="4">
        <location>
            <begin position="22"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF46961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC68247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="307" mass="35077" checksum="3E74D39A9393352A" modified="2016-11-02" version="1">MIYFKTNLLIILPIFTSIVKAWNSDNHTCALTKPIFSCENQTTILDTCCTPTEGLVLITQYWDTYTGLESEKSFLPLNSWTIHGLWPDRCDGSYGQYCDLSRQYDPFPSPNTTNGKIDGIPVPIWQGGDIITPLLQKYGKYDLLSYLEKYWKSQGSPDWTFWQHEFSKHATCFSTYDVGFEGVPNCYGSIYQNSTEASIIDFLESVIKAQIQYPTYEWLSDEGIKPSNQTGYNINKIQDILTKASGAQPYLGCYGPTKQILSEVWYYSHSLGRPQEGILKPINQTTKTNCNSTQPIWYYERTPGSEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HV39</accession>
    <name>A0A1B9HV39_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_06915</name>
        <name evidence="9" type="ORF">I206_101993</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV700117">
        <property type="protein sequence ID" value="OCF47137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC68074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019158610.1"/>
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    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
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    <dbReference type="PANTHER" id="PTHR47338:SF29">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="163"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="348"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="413"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="482"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
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            <begin position="121"/>
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            <begin position="348"/>
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            <begin position="374"/>
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            <begin position="509"/>
            <end position="531"/>
        </location>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF47137.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC68074.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1003" mass="110037" checksum="DAB1163BFB80B0B1" modified="2016-11-02" version="1">MQQRPLVQSDWQVQQDDTSQFTNWYPSEYSSDEWTHFQPQQLDASRYDQPSGSSNPVYQQDFGSTIHEPRRMSGVPSLGEKESVSPEAGGSDTSSMNRFALLNAPTSSSSSSGDLNGMMSEGSQQAGQGHSYQEQGSSYSGPSGIASIDHIAPSGTSLRRGMACKFCRRRKLRCSGERPACSSCVKYKQECEYQPPAKAQKVQALESRVAELSDIINQGSVPNIPPAFSSQPLTYDENALQQPVYGGSYHNDSQDQTPYLNYTLPLTGDSSNSSTFTPNVNMNGQAFNAYADAATSQTAINMAFPQPGPHNQYAYPLIPENVQFATNTSQANTLQEIAVPPSYPIYNSHPSSSPLPKATFNSGNQDGSIPINYSYPQTHSMPSLPSQNLPLSTSHAQYPARPAALLTHQLSITSESSTSNGQTANTPSGSASTSGSIHAPPGPQTIYAEAASLASLRYTAELADSGDPVDKITERLGEFLFSPTDTSGQLGKDDFDDAVDTTKKRRTGKVQSGQWAKSSSTRPDGPNRTSLFRSRIETDGLRDEDRDKLLEVFFGHSRLFFEMSIPRFRYRMSFNDRTRPSLALLNAMYLWATRMTASPNLSAMEAHFFAEACRHLDSAGPNSDRLIDAVKAAMLLCAYSYTNGRHHEGWLIAGLAVRLVSSTGLHQIPSLTFRPAHADNPFLRNRVHLLPPPEDAVELAERVHAFWCVYAIEKCGAFATGFPSSLRDEDIATPFGRPLDQIASQSVTLQDDVTIRDLYRGTAFPHPDGDSPYIRWIKAVTILERASKLAFLTPTDDSEYTQAWTAYASALGTSSSTGSPPPKLPPGWLNQPKYRNSKDYDDCSRALTHYIDSLGVEGISPVERRKMAEQEGSVEPVIKSHTILLHHETIAAEMLMHDINSLDTENEVAVSAGRRSAELIRALPPIPPQEVDAQVILVWCMIIKLLIKELRRCTKLGDQSASKSIEDDVDILIKEMSRIGVIMHIARTQSKAMDDFKKAALAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HVW5</accession>
    <name>A0A1B9HVW5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Formamidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_06309</name>
        <name evidence="2" type="ORF">I206_101724</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008629.1">
        <property type="nucleotide sequence ID" value="XM_019158016.1"/>
    </dbReference>
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    <dbReference type="STRING" id="1296096.A0A1B9HVW5"/>
    <dbReference type="GeneID" id="30174678"/>
    <dbReference type="KEGG" id="kpin:30174678"/>
    <dbReference type="OrthoDB" id="9975579at2759"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.580">
        <property type="entry name" value="Acetamidase/Formamidase-like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="FmdA_AmdA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891">
        <property type="entry name" value="FORMAMIDASE C869.04-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891:SF1">
        <property type="entry name" value="FORMAMIDASE C869.04-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03069">
        <property type="entry name" value="FmdA_AmdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141130">
        <property type="entry name" value="Acetamidase/Formamidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCF47410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC67810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="47924" checksum="800E6D99E3378DAA" modified="2016-11-02" version="1">MPVATKPKRTSNEVPTLVTVDPSQPGASQANIHTRWHPEIPCVATIEVGKPFRVECLDYSGSQVHNDDNADDIVHLDHDSDHHLSGPFFVPNSQPGDVLEIEILDVQPFPNHNWGYCVTAPELGSLDDNDDPKRQTKVTKSIWDFFGNETSSRHVPHVSFQGRPHPGVLGTAPSHQLLGQWKKRESELEIETAGKAGCSLPQSRGAYVGQDISDELRERIYSEGARTSPGREHGGNIDIGLATRGSKMYLPVYIPGASLSVGDLHFCQSDGEPTTAIEMAGIATLRVNVIPQGIRQLCMKSPMFRTSPTEPLYRDKICFTGLSVDRTGKQTNQNGLLAYRNAAFQAIEYLESFGYSREQAYILLSAAPIESRVIATANRPNFVISLGIPTEIFDFDILPRSEGITDQEKKRIIQGPAIPSITVDRKVANGFNHEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HWT5</accession>
    <name>A0A1B9HWT5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_06640</name>
        <name evidence="3" type="ORF">I206_101390</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Murphy C."/>
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                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
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    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 10737</strain>
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    </reference>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HXE3</accession>
    <name>A0A1B9HXE3_9TREE</name>
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        <name evidence="4" type="ORF">I206_107470</name>
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        <lineage>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
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    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
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        <property type="protein sequence ID" value="OCF47934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="term" value="F:protein phosphatase 1 binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:regulation of glycogen biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Carbohydrate binding type-21 domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CBM21_dom"/>
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    <dbReference type="InterPro" id="IPR038175">
        <property type="entry name" value="CBM21_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050782">
        <property type="entry name" value="PP1_regulatory_subunit_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307:SF36">
        <property type="entry name" value="GLYCOGEN-BINDING SUBUNIT 76A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03370">
        <property type="entry name" value="CBM_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51159">
        <property type="entry name" value="CBM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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            <begin position="397"/>
            <end position="515"/>
        </location>
    </feature>
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            <begin position="1"/>
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        </location>
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        </source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HXI4</accession>
    <name>A0A1B9HXI4_9TREE</name>
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        <name evidence="10" type="ORF">I206_107499</name>
    </gene>
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        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
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                <person name="Dewar J."/>
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                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Murphy C."/>
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                <person name="Sykes S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
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                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Murphy C."/>
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                <person name="Shea T."/>
                <person name="Sykes S."/>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
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                <person name="Hansen M."/>
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                <person name="Imamovic A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
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            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">CBS 10737</strain>
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        <property type="molecule type" value="Genomic_DNA"/>
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<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
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    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
                <person name="Sun S."/>
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                <person name="Zeng Q."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="Young S."/>
                <person name="Zeng Q."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
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                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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                <person name="Litvintseva A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
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                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
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                <person name="Litvintseva A."/>
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                <person name="Litvintseva A."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC73144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009786.1">
        <property type="nucleotide sequence ID" value="XM_019157068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HZ46"/>
    <dbReference type="GeneID" id="30173715"/>
    <dbReference type="KEGG" id="kpin:30173715"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF48567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC73144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="121" mass="13900" checksum="1C9CF39103386D1E" modified="2016-11-02" version="1">MRELGYSVECALQDLEKMNFDLITQQKQSLYNLGNGIYGINGTYTTYQLIHMVESLPEPQRSRKNKNKTKGKAQSSKFPIVDPGYDNGNWIRVYDPRLTRPMVLGDYLVKWSNMGITAMTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HZD0</accession>
    <name>A0A1B9HZD0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">chitin deacetylase</fullName>
            <ecNumber evidence="20">3.5.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">I206_05423</name>
        <name evidence="25" type="ORF">I206_107034</name>
    </gene>
    <organism evidence="24">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="25" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = chitosan + n acetate</text>
            <dbReference type="Rhea" id="RHEA:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57704"/>
            <dbReference type="EC" id="3.5.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:10465"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the polysaccharide deacetylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.41" evidence="20"/>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC73069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009862.1">
        <property type="nucleotide sequence ID" value="XM_019157144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HZD0"/>
    <dbReference type="SMR" id="A0A1B9HZD0"/>
    <dbReference type="STRING" id="1296096.A0A1B9HZD0"/>
    <dbReference type="GeneID" id="30173792"/>
    <dbReference type="KEGG" id="kpin:30173792"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.370:FF:000004">
        <property type="entry name" value="Related to Chitin deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF133">
        <property type="entry name" value="CHITIN DEACETYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="18" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="12" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="16" id="KW-0170">Cobalt</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 22" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628206" description="chitin deacetylase" evidence="22">
        <location>
            <begin position="20"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="23">
        <location>
            <begin position="182"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00024056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="OCF48643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="WWC73069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="498" mass="51106" checksum="476F590F6604D585" modified="2016-11-02" version="1">MSRIATTALLFSLLSGAYAQSSAAAAAATSAGSAAASGATLAQTGTSVDASIISLTATVSAPSGFSIPALSELTSGASTDTTIALDTTYAAGSTPTAVSGAPALPTSALTIANYPALDVAPPTDSTEVQQWLSKIDMSKVPTYNTTTGDCSTDPTAITDGRCWWTCGGCTRETDITECPDKMTWGLSYDDGPSPFTPLLLDYLDEQNIKSTFFLVGSRVLSRPEIVQSQFMAGHHLSVHTWSHTALTTQSNEQIVAELGWTAKVIRDVTGVTPNTFRPPYGDIDDRVRAIAAQMGLTPIIWTSYREGVTDTNFDTNDWHIPGGTATGASSFQTFDTILNEYVPKLDTGFIVLAHDLYQQTVDLAVGYVLPQAISSGKFQLKSIIECLGKPITEAYIETSANATTTEITSVDGGSTYFQASIGTATGSLASITTGSAAASGSAASGSSGASGSSGASGSASASKSSAGSTSGASRLVLDKLIPAAVAFSVVALGMMIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HZL4</accession>
    <name>A0A1B9HZL4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
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                <person name="Imamovic A."/>
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                <person name="Wortman J."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
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                <person name="Young S.K."/>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
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    </evidence>
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</entry>
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    <name>A0A1B9I0T0_9TREE</name>
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        </recommendedName>
    </protein>
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        <name evidence="6" type="ORF">I206_105915</name>
    </gene>
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        <lineage>
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            <taxon>Cryptococcaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019156468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I0T0"/>
    <dbReference type="STRING" id="1296096.A0A1B9I0T0"/>
    <dbReference type="GeneID" id="30173107"/>
    <dbReference type="KEGG" id="kpin:30173107"/>
    <dbReference type="OrthoDB" id="9992747at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004053">
        <property type="term" value="F:arginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09999">
        <property type="entry name" value="Arginase-like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782:SF3">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF49051.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC71956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="28162" checksum="64036649D0E8743F" modified="2016-11-02" version="1">MRYTSATLPAIKRSSSTYSLLHYVGRSGDHNDKAMQATPILAKHLSNELNMDPTVIGKPENALNRGWEEELKAALPNYKIISEKLDQVLNEGKKPIIALSRCSVALATLPIIAKHYPDIIIVWFDAHGDLNTPSSSDTGFLGGMALSGPIGLWESWMKGKKVKTENELLRTIDNIEEGRKRIFIHLDCDVLNPGIVPTDYKVPGGLSIQQLKDAISGLSESSDVIGIQISELEFGDSEKETQDAAKLLVDSIKPVLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I0U1</accession>
    <name>A0A1B9I0U1_9TREE</name>
    <protein>
        <recommendedName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I206_04821</name>
        <name evidence="17" type="ORF">I206_105998</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49134.1"/>
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    <name>A0A1B9I0Y3_9TREE</name>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">CBS 10737</strain>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
    <reference evidence="2" key="3">
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            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
        </source>
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            <dbReference type="EMBL" id="OCF49175.1"/>
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    <accession>A0A1B9I145</accession>
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    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
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                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Roberts A."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <source>
            <strain evidence="10">CBS 10737</strain>
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    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
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                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="McCowan C."/>
                <person name="Murphy C."/>
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                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SNAP family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010478.1">
        <property type="nucleotide sequence ID" value="XM_019156676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I145"/>
    <dbReference type="STRING" id="1296096.A0A1B9I145"/>
    <dbReference type="GeneID" id="30173316"/>
    <dbReference type="KEGG" id="kpin:30173316"/>
    <dbReference type="OrthoDB" id="9984275at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005483">
        <property type="term" value="F:soluble NSF attachment protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15832">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000049">
        <property type="entry name" value="Alpha-soluble NSF attachment protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000744">
        <property type="entry name" value="NSF_attach"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768:SF8">
        <property type="entry name" value="ALPHA-SOLUBLE NSF ATTACHMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768">
        <property type="entry name" value="SOLUBLE NSF ATTACHMENT PROTEIN SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14938">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00448">
        <property type="entry name" value="NSFATTACHMNT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF49259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC72163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="289" mass="32409" checksum="CD1391E55BFBA595" modified="2016-11-02" version="1">MGKSQAEEYLAKAEKKSSSSVGWFGSSSSKWEEAGDLFAQAANAFKVEKKWRESGQAFEREAACRQQANETNDAMNAFHNAAKSYKKSDPEAAVTALHQCIKLLVNSGHFRQAADREKEIAGIYAQEGLDVAKARDSFVRAGDWYKQEDANATANQCYQQAAELSADLQDYQRSMELYQTVADWSLTSALTKYSVKEYWLRAALCSMAMGDLVTTQRLLETFAQKDVTFPSTREAKFAHELMDACEQADVERYTAAVYQYDQVTKLDNWKTGVLLRIKKALEEDEGGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I176</accession>
    <name>A0A1B9I176_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription initiation factor TFIID subunit 12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_04992</name>
        <name evidence="9" type="ORF">I206_106167</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010521.1">
        <property type="nucleotide sequence ID" value="XM_019156719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I176"/>
    <dbReference type="STRING" id="1296096.A0A1B9I176"/>
    <dbReference type="GeneID" id="30173361"/>
    <dbReference type="KEGG" id="kpin:30173361"/>
    <dbReference type="OrthoDB" id="2193432at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07981">
        <property type="entry name" value="HFD_TAF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037794">
        <property type="entry name" value="TAF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003228">
        <property type="entry name" value="TFIID_TAF12_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264:SF21">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03847">
        <property type="entry name" value="TFIID_20kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 12" evidence="7">
        <location>
            <begin position="468"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="118"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="193"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="272"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="544"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="135"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="272"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="321"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF49302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC72206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="577" mass="61731" checksum="8E5D0B3DF5630D31" modified="2016-11-02" version="1">MSQAPAGPSTPGGITRPPVQNQSQTTINTIVHNLPNLFAMHSRNELSESQLIQLRNLMHTHFRQVIASSMAANRPNPLLDLPPAIDPTMPFMGKPPLISKEAYTALINTTTQHIREAMNQRAQQAKKDAQAQAQSQNTTQFPSSSTGTSAPNQIQPQIAGNPPQASNVQTTNNTSILNPINNAVRPIQVPQGAVTSSGMANPAPIPQQTTMSSIPTTSSQAQLTSNGLPPGVLPYSTMRAIMKLTQEQRTKWLKEDPSRTGAFSVSAKYWTSRTATTNPSNTSTAGPSRSTPSPSQSQLQAQTQLPTSIAPSALLTPPIPQQTNTVPPANAQQSTSVPAPTTSTAPTINTAAPSVVQLSTKADSASAHLQPSTVEDTSKSDKSIPDQTKQTPSDPPPPTGEAGIKTEVTTTISSADPALPPAAANMENAVIATVTGKEGGFATALPDPKVFALKPPPPPPEPENVRRKRKCKEFIGELHPGLEMEYGVDKVIGDILDELIDEGLKGATRLAKHRKSDKVELKDIAFFVDQCWGLENPGFDALGHTHRKTHIPPERERRRTRVVNPRAARLGKAREED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I1B8</accession>
    <name>A0A1B9I1B8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CDC20/Fizzy WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_05018</name>
        <name evidence="9" type="ORF">I206_106193</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010546.1">
        <property type="nucleotide sequence ID" value="XM_019156744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I1B8"/>
    <dbReference type="STRING" id="1296096.A0A1B9I1B8"/>
    <dbReference type="GeneID" id="30173387"/>
    <dbReference type="KEGG" id="kpin:30173387"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF1">
        <property type="entry name" value="FIZZY-RELATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="7">
        <location>
            <begin position="241"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="378"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="512"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="51"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="119"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF49327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC72231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="568" mass="61318" checksum="FB04DB5ED25C4539" modified="2016-11-02" version="1">MSGRLLDGGRFIPDRNGHNLHAVYQFNTDPNPKEATFTKLLRTELSPIPLHDSTPIAGPSNYSTDYPLSNAGHTPLHHHPPPSSMGERESSPASSLPPLAQHAPPTPTSGHGRPPGAGPSSSHMRAHQSQVALTSSAARQRSSPNLNGRSAFSPPPGNTANMNNSSPSTPKKKRILNFTSPSSPRSLGGLSGARGISGDGGLDDMSHPAYSLSPIGKESQRILQSPRKQIRSIAKTPFKVLDAPELADDFYLNLVSWSASNVLGVGLNSCVYLWSAQTSKVTKLCDLVRVAPDGQEISDTITGLEWTNKGSTVAIGTNSGLVEIWDAEYCKRIRTMSGHTGRVGALAWNNHILSSGSRDRTILHRDTRIPEHYIRKLQGHHKQEVCGLRWNSDTDQLASGGNDNKLFVWGGTDSKPTWRFGEHRAAVKAIAWNPHQRGLLASGGGTADKKIRFWNSLTGGLVSECDTGSQVCNLMWSRNSNELVSTHGYSGGPVSNQIHIWKYPSMTQIATLTGHTYRVLYLAMSPDGQTIVTGAGDETLRFWNAFQKAKGEVGKGFGDGMGVLAKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I1H1</accession>
    <name>A0A1B9I1H1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CMGC/CDK protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_05048</name>
        <name evidence="8" type="ORF">I206_106222</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010574.1">
        <property type="nucleotide sequence ID" value="XM_019156772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I1H1"/>
    <dbReference type="STRING" id="1296096.A0A1B9I1H1"/>
    <dbReference type="GeneID" id="30173417"/>
    <dbReference type="KEGG" id="kpin:30173417"/>
    <dbReference type="OrthoDB" id="413582at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008024">
        <property type="term" value="C:cyclin/CDK positive transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF546">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCF49355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC72260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="449" mass="51866" checksum="A975978E47AB7847" modified="2016-11-02" version="1">MMIHIAQGRQGDIYALKSRDINENDNIHYHKNKDEEGQLEHSLASDEIDVYGGLKEWQIIKTVYAPLNGVVIGKQPHNIVKEVNLLKRINHPNITTLLRYTFNNDTFEHQLIFPLYAITLNELFQDSSFPFEYEHEQITHIQNNPLDIPKYISYQLLQGINYLHNLNSPISHLDLNPSNILLDWNGLLKIIDFGISFSLTTKDQEEFSNCIKEEDNEFTLFCDVGTGSYRAPELLFSPIRYDPLKIDLWAIGCIIAQLFRPFESIEINSNFGSESSSSSSSSSSTKSSLIEISNNSIKEQFDIFDNLDNLKFIRKPLFNSKYGSLGLSSSIFKILGTPTKENWPDFENLPDSSKINFPFSKSKKLLNYLPELNKFNNENKNDILEIIEGLLKLDPNLRKNTKEILNFKWFNNLPLIQSNEIMRKYLIIAKSNFIRKINEDTTNPQGRVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I1Q5</accession>
    <name>A0A1B9I1Q5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_03983</name>
        <name evidence="4" type="ORF">I206_104436</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010681.1">
        <property type="nucleotide sequence ID" value="XM_019155723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I1Q5"/>
    <dbReference type="STRING" id="1296096.A0A1B9I1Q5"/>
    <dbReference type="GeneID" id="30172352"/>
    <dbReference type="KEGG" id="kpin:30172352"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="186"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF49462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC70485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="348" mass="39440" checksum="DC00676889D2ED9F" modified="2016-11-02" version="1">MPDIEMLKDRSAVGSMSTQRLPIVDISPYLDPSSTDEARKEASQTLDKACREFGFFYVTGHGLDPEYMKDLLKLGHKFFELPQEKKDAIHIFKSMDRVRGYQKLGENVTYAKRDQQEALDIYPEPVNPSTAQLEGSQLWPAEEDLPGYKATLLDYAEKMKKIGHAFMKAMSDVLGHEELFEQLQDDNYWVLRVIGYPPLSDSHDLESGISCGAHTDYGCLTFLLADDTPGALQVESKDGSWIPADPIPGAYVVNIGDIIDTLTGHQYKSTYHRVIHRGSRYRVSMPFFFEPKRDQVIQNLPGMLPEGEKPVEPFTYFDHLKRMIYAHFVANDEALPEKPNANALTQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I1Z1</accession>
    <name>A0A1B9I1Z1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_03989</name>
        <name evidence="2" type="ORF">I206_104430</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010687.1">
        <property type="nucleotide sequence ID" value="XM_019155729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I1Z1"/>
    <dbReference type="STRING" id="1296096.A0A1B9I1Z1"/>
    <dbReference type="GeneID" id="30172358"/>
    <dbReference type="KEGG" id="kpin:30172358"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCF49468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC70479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="129" mass="13929" checksum="91F63EF4BCC321FA" modified="2016-11-02" version="1">MGCAGDQATNCGGSNLLQLYNNPDLATKNTINSGFTYQGCMEEVLGRALSPTSIITSNLTIENFSMSVRHLDTSMLVLNTPTNASLRTNLTMDQYFSNQCNIPCISNNGQICGGPNAITLYAYAMSRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I221</accession>
    <name>A0A1B9I221_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_04089</name>
        <name evidence="4" type="ORF">I206_104333</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010786.1">
        <property type="nucleotide sequence ID" value="XM_019155828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I221"/>
    <dbReference type="GeneID" id="30172458"/>
    <dbReference type="KEGG" id="kpin:30172458"/>
    <dbReference type="OrthoDB" id="10486014at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="550"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="665"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="553"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="675"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="691"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF49567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC70383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="720" mass="79110" checksum="89803CD2A2C25261" modified="2016-11-02" version="1">MSVATATAPSITGWQDLSCQVKRSMADTINSDVKLRGAHAGNRWVSDGATQDGKNYDRDLELNTDHNNGYDGSFGASAPIGGKITMGNLKHYLLSLKEKNAWKDDEDLREKVQSLIDKPGNSFRAPMSTKESTEYTSIRKSSPEGQAKYVARKGDQEKAIQMINETYEKGKLTAESWLKGELSDQVETKLDITNIDYFFKNHNDTSTDPKARRQVHRFILGEESIVKMSYKDSVKLNEGLDDLNKEANKIHEESGKEGISKWRKDRHEKLANLAKKWGTTNSGISESDWNSELEKTKSDLKARAKTQQAKAEAAEREKLGPFTATETILNSANVDSFLDTQIHLAKDPKIRESVLSVLAGGKPVKVDVGTDDSLKKFQESTKSTETVISEFDHETDQSKLGDKVKAWQEARKRKVESLISKWEETSQVPRDRWISRNTPDLKDTQAVVSLMNVDTFLSDYSSMAKDPSAQAAVLRALQQKGTVVDLGSTEEASTLNKASKEFERQMMKFKENEDVEGTKLWQKQRMEGIGKTLAKWEEIAGKSYKEWNTEARSSAGDQGNSGSGSSSGSSVAVLRSSNIESFLQTQSSLARNPDVLKAVTTVLTAGGHHEVDVGSSEAASSLTKAAVDTQKTASKYRDKGRRAFKKWSSEREARIDKYLGEWSQISGIPKEHLRGGGSSRGGGKSQSNPESSGSTSNDGSGSDSSTPSHSSGPQAVTSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I274</accession>
    <name>A0A1B9I274_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA (guanine(26)-N(2))-dimethyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.216</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">tRNA 2,2-dimethylguanosine-26 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA(guanine-26,N(2)-N(2)) methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA(m(2,2)G26)dimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I206_04127</name>
        <name evidence="15" type="ORF">I206_104296</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:43140"/>
            <dbReference type="Rhea" id="RHEA-COMP:10359"/>
            <dbReference type="Rhea" id="RHEA-COMP:10360"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74513"/>
            <dbReference type="EC" id="2.1.1.216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.216" evidence="7"/>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010824.1">
        <property type="nucleotide sequence ID" value="XM_019155866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I274"/>
    <dbReference type="STRING" id="1296096.A0A1B9I274"/>
    <dbReference type="GeneID" id="30172496"/>
    <dbReference type="KEGG" id="kpin:30172496"/>
    <dbReference type="OrthoDB" id="6349953at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160104">
        <property type="term" value="F:tRNA (guanine(26)-N2)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002940">
        <property type="term" value="P:tRNA N2-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.70:FF:000001">
        <property type="entry name" value="tRNA (guanine(26)-N(2))-dimethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.70">
        <property type="entry name" value="N2,N2-dimethylguanosine tRNA methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002905">
        <property type="entry name" value="Trm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042296">
        <property type="entry name" value="tRNA_met_Trm1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631">
        <property type="entry name" value="N 2 ,N 2 -DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631:SF3">
        <property type="entry name" value="TRNA (GUANINE(26)-N(2))-DIMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02005">
        <property type="entry name" value="TRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51626">
        <property type="entry name" value="SAM_MT_TRM1"/>
        <property type="match status" value="1"/>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I2C2</accession>
    <name>A0A1B9I2C2_9TREE</name>
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        <name evidence="4" type="ORF">I206_104208</name>
    </gene>
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        <lineage>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I2T6</accession>
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        <lineage>
            <taxon>Eukaryota</taxon>
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    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
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        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
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        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
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        <text evidence="2">Belongs to the universal ribosomal protein uS13 family.</text>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.910.10:FF:000004">
        <property type="entry name" value="Small subunit ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="entry name" value="30s ribosomal protein s13, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="Rbsml_uS13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_uS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_uS13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US13M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF49778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC70172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="207" mass="23001" checksum="AA730B9D58098A6F" modified="2016-11-02" version="1">MHLLGHNLPDHKPLKIALLTFYGLSHTLSSRLLARLSIHSEALVSDLTEPQLTSLSAYLSSPSTTLKSQKDSLIKLSPPGGRILSLPNNHNNKFNFELNNNSNNANLNLKGKGKEDPLDELLLETEARRSMQSDIAHLRMVGTYRGKRHAAGYPVRGQRTQTNASTAKKHNRVERRGFTTSVIRPSFGITQIPSPPSRILRELSRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I3K6</accession>
    <name>A0A1B9I3K6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">beta-glucosidase</fullName>
            <ecNumber evidence="3 7">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_03427</name>
        <name evidence="10" type="ORF">I206_105671</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3 7"/>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011329.1">
        <property type="nucleotide sequence ID" value="XM_019155175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I3K6"/>
    <dbReference type="STRING" id="1296096.A0A1B9I3K6"/>
    <dbReference type="GeneID" id="30171796"/>
    <dbReference type="KEGG" id="kpin:30171796"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000006">
        <property type="entry name" value="Beta-glucosidase H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF10">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56988">
        <property type="entry name" value="Anthrax protective antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA14" evidence="8">
        <location>
            <begin position="417"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCF50110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC71713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="864" mass="97412" checksum="07EAE0A428BD35F6" modified="2016-11-02" version="1">MTFTTNDKMDRSFLTASIPELIKQMTEEEKISILAGKDWWHTVPIPRLNIPSIKVTDGPNGARGESFYHMCPATALPNATCLAATFSDELAEMSGSLLAEETKARNASCLLAPTINIQRSPLGGRAFESFSEDPTLSGLMASSYINGLQNKGISATIKHFVANDQEHERMGQDSIISPRPLRDIYLKPFQIVQKKSKPWAFMTSYNKLNGIHCSENELLLQNILRKEWNFNGLIMSDWYGTYSVSDSLNSGLNLEMPGSTKWRTKELISHSIYSHKIDTRILDKRVLEILNWIQKLSKLNENLVYQKPKSEKTRLENKEEDSKLIRRIGGEGIVLLKNENNILPINKPQNIGIIGPNAKTKVITGGGSAQLRASWSISPWEGLIKNKPDGIELSYTLGAATWKFLPILGDEFYTTDGKQKGFNLKHYAIDENGKQVQNPAVEEIWDTSDLIMADFYDPNLGEEYFTEILSLFKPTKTQEWEFESVVTGQGWLWIDDILILDNSKYTHKGSAYFGSGTEPKKAIFKVEAGKTYKIRYLHDSRFPSTLLEIKSTPIKMIGVRLGAFPKIDSEQAILEAVELAKKVDVPIIIAGLNADWESEGFDRPNLSLPLKTDELIDKVSKVNSKTIVIIQAGSAISMPWINQISGLIYSWYGGNESGSSISDIIFGKLNPSGRLPLTLPIKETDIPSYLNFKSAKTKTYYEEGIWVGYKWYNEKQIKPLFPFGFGLSYTTFNYSNLKIINITNDIVNADEWKLEVQVKLTNTGNKIGSHSIHFYTCPPEETSTSLKHPKQTLQAYKKVKDLKPGASEIVNVTLDKYAISHWDERWNTFRAEQGEWSVKIGKDAQTMIGEVKFTIDQELEWTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I3K8</accession>
    <name>A0A1B9I3K8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_03430</name>
        <name evidence="9" type="ORF">I206_105668</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">CBS 10737</strain>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="9">CBS 10737</strain>
        </source>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
        </source>
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        </source>
    </evidence>
    <sequence length="420" mass="46890" checksum="196AF71034EDBD64" modified="2016-11-02" version="1">MPANIALLGSGVFAKASYLPAILSLHGDVLNLHSIWSRSSSSVESFLSEIKKESSNSNLTSNSKELKPELKFGENGLNEILLNKEIDGVLIVLPISSQAEIIKKCWKSNKHVLSEKPIAKDLKIAKNLIEEYEKEYKPKGIIWRVAENYAHEPILREAGKIISNTPELGPILFWQLNFQGYIEDGSKYQSTTWRTIPDYQGGFLLDGGVHWIALLRTVLPLGALPNSIISIKSLHRTHLLPYDTIQSISLPLKSSITNSHGPKTKVKTAEFNEKDIIGEIGKSFPTGQILMSFAISELPNELNSKSQINGLKIHFLNGLIEITCEFNEITKQREFIFELIPSIGSSSKNLKNNKINGPMNGVEIEIKMFCNAINDFKNEKSILEEDDFGKPRDALYDLSVIQAMLESDGKELKIDNSIDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I4C6</accession>
    <name>A0A1B9I4C6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA replication complex GINS protein SLD5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_03689</name>
        <name evidence="10" type="ORF">I206_105405</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GINS4/SLD5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011587.1">
        <property type="nucleotide sequence ID" value="XM_019155433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I4C6"/>
    <dbReference type="STRING" id="1296096.A0A1B9I4C6"/>
    <dbReference type="GeneID" id="30172058"/>
    <dbReference type="KEGG" id="kpin:30172058"/>
    <dbReference type="OrthoDB" id="338231at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11711">
        <property type="entry name" value="GINS_A_Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21692">
        <property type="entry name" value="GINS_B_Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008591">
        <property type="entry name" value="GINS_Sld5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031633">
        <property type="entry name" value="SLD5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038749">
        <property type="entry name" value="Sld5_GINS_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21206:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21206">
        <property type="entry name" value="SLD5 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="8">
        <location>
            <begin position="150"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="98"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCF50368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC71449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="312" mass="36665" checksum="8618D5D77D9DCBC6" modified="2016-11-02" version="1">MSFFDDDDDEEDDSLINNGINQRGSSSRTTRENSSLFIDRLRSTVSPHSEEIQIQIQIERERERSKASESIFDESNLSLSNFNENNFENQIQIQNYEKDEEDDDYDEEEEDLNDIKKLNKFWIKERGIPELSNWQGDLIDEIFDKLEQQQKMVNTLNSDPQTSEEEHFKLMLVQTEMERVKYLIRSYVRTRLHKIEKFSHYITVTPNTHHLLSGAELSHAKRYTDLLHTHFEHSVLDSLPEWLRKMDDTYGDGLSMISKPNRNTPVLIYCKRDCGEITLEGGERAALAKGTTHLVKYKLVDRWINLGWAEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I4F5</accession>
    <name>A0A1B9I4F5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_03723</name>
        <name evidence="4" type="ORF">I206_105368</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011621.1">
        <property type="nucleotide sequence ID" value="XM_019155467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I4F5"/>
    <dbReference type="GeneID" id="30172092"/>
    <dbReference type="KEGG" id="kpin:30172092"/>
    <dbReference type="OrthoDB" id="2342176at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628367" description="DNA-directed RNA polymerase" evidence="2">
        <location>
            <begin position="20"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF50402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC71412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="38714" checksum="1629B3ED42DF53A5" modified="2016-11-02" version="1">MLTRSTILGSLLLANSAFAHCQLAWPFPLHSPLNPATPEAIKDYSMTSPLISDGTYPCKGFINNPSSGMGSVASLAAGSNMNYTVAGTATHGGGSCQISMSYDQGSTWNVIYSVVGGCLVDGMTTTITIPSDAPSGEALFAWGWFNRLGNREMYHNCASVTITNGGSGLNAQDYPTPFVANADVNGCKTIEGVDVVFPNPGKNVHYGGSYASTKPTTPTGFTGSNCVGPGATESSSSSTSASSSISSVQASPSSTTTSQGIAVSASVGVTVGNTPSSVSSASIVHPSDVGYSLSLGPSSTALTPNDNAAEPSSTASSSSGKTCNRSRKRSKGNGKPHQRLIRRPRAASGRVAASKAEHIVHQRKRGTGRVAALPATHNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I4Z4</accession>
    <name>A0A1B9I4Z4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prp8 binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_03922</name>
        <name evidence="5" type="ORF">I206_105168</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
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    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="OCF50597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC71215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="component" value="Chromosome 7"/>
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        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="U5_snRNP_Component"/>
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    </dbReference>
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    <dbReference type="PANTHER" id="PTHR44006">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR44006:SF1">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
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        <property type="match status" value="6"/>
    </dbReference>
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        <location>
            <begin position="66"/>
            <end position="98"/>
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    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
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        </location>
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        <location>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF50597.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC71215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
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</entry>
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        <recommendedName>
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        <dbReference type="NCBI Taxonomy" id="1296096"/>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC71190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I521"/>
    <dbReference type="GeneID" id="30172316"/>
    <dbReference type="KEGG" id="kpin:30172316"/>
    <dbReference type="OrthoDB" id="3554264at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010895">
        <property type="entry name" value="CHRD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07452">
        <property type="entry name" value="CHRD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00754">
        <property type="entry name" value="CHRD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628392" description="CHRD domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="CHRD" evidence="2">
        <location>
            <begin position="46"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="CHRD" evidence="2">
        <location>
            <begin position="212"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF50622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC71190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="382" mass="40559" checksum="3F7EAC864B3FF6BE" modified="2016-11-02" version="1">MLFKLLLALAASASALAARTYSEDKHDKYGDKPYGKVVSEPKYFTSAFSTRAVPSQVVVTNGTVDPRNSTAYGHFGFKINSDKDIICYDISLVNVTGGYSSPAFTATHIHQGPQGAAGPPRLAFPNPEFVGYDRNGAELRRSKGCLRGPFSTNITANGKDTGSDSGFTLKAIEDSPSSFFADTHTAQYTAGAVRGQLLASEVPVKKPDYFTSTLRTDATGEQVVNGSSVSVPGSNGTKGVYVLHINSDKDIICYEIVVDGFPEGQDYFSPAKTATHSHSGIFGQTGPPRLALKNPKPVEDDWKSISLFNSLLGKKKTAGIRVASACVKGPFTTGLLDVNGTDTGSASGFTLKQLEQNPSAFNADFHTSGFVAGAVRGQLYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I5C1</accession>
    <name>A0A1B9I5C1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_02779</name>
        <name evidence="11" type="ORF">I206_102430</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF50723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011942.1">
        <property type="nucleotide sequence ID" value="XM_019154539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I5C1"/>
    <dbReference type="STRING" id="1296096.A0A1B9I5C1"/>
    <dbReference type="GeneID" id="30171148"/>
    <dbReference type="KEGG" id="kpin:30171148"/>
    <dbReference type="OrthoDB" id="289162at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19494">
        <property type="entry name" value="Elp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008728">
        <property type="entry name" value="Elongator_complex_protein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896">
        <property type="entry name" value="PAX6 NEIGHBOR PROTEIN PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05625">
        <property type="entry name" value="PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="434"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="475"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="490"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="518"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF50723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC68501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="528" mass="57790" checksum="1182B85114D9B531" modified="2016-11-02" version="1">MPSFTRRVPSNTIPPPGGTHPSPSLSSLNLLPTGLPSLDDLLGGGIPLGSILLILTPDKQSSWSKLIERYWISQGLISGQSSLFVSENYEIGKELIKNCMWYDKFKSSSSSSSSSTKENNIGSASETELEDNDFNENNEAKKIAWRYEKMGKFKTTVGGNGSNLSLMNTIPQDVLDSIHKTGQQTYVNLEQVENTSEASSSSINITSPNRFDIAIKGIYDHVQKSDPKRAGRITIHELGGLDWGDEVSFEQIHRFIHSLKSIIRTKSTSALITIPPHLLSGPLSESLIRKLSWSVDACVELKGFADDPTLPPQFPTTHGLIKLLSFPTCYTLLPSTLKYSTLLGVSQNSGTDNNGGGGGGAGENNLGFKLKRKKFTIETLHLGVEGGIGERSTEKPDINSAFSGISIKSTPTTTTITEGIEKSKTLNDSTLEIGLDKPIGPIEEKQKSTKKARARVRFGGEEEMVINKDEGKSNSHSHSHSHSHSHSHSHSHDHQHTHEHDHAPVESQGKSSTPRIQVRHDRPDLYEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I5R9</accession>
    <name>A0A1B9I5R9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HhH-GPD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_02927</name>
        <name evidence="3" type="ORF">I206_102576</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF50869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012088.1">
        <property type="nucleotide sequence ID" value="XM_019154685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I5R9"/>
    <dbReference type="GeneID" id="30171296"/>
    <dbReference type="KEGG" id="kpin:30171296"/>
    <dbReference type="OrthoDB" id="4676at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF50869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC68645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="45102" checksum="A2E7DF32E84DDEC3" modified="2016-11-02" version="1">MTSRAATKRANGMKRKYEEASNDVISSPSGNGTDSELSELDDDYLSAADEDDKPPKKNKKANANGKSSPGRLKSKAKTTKSENNLKAESIKSKAKAKNDESTKSPEKKSRKSKTDEEVKPRIKSSNPEKLLEYLLSDEALDYSNPLPEKGFGEKDWFKNSSPNNSFEKLENPIPRPKLSKKAEKSIGVGEKIKLPEGYLRYPHSNMTPFQILLSSLLLSKPLSHKMGLRTISTLLNPPFNFGKFEIFEKSDEDKFRESLLSARTQHREKTVNQLIDFAQGVKGLNGEGEENDLNGIKRAIENLNNVEKAQIRVGEMLKSLKGIGPVGVGIFLRRIQGQWEEVFPYVDQRCLDAAKSIGLIKETGNANNMAELCNNDSTLLVKLLDTLIGLDLEKKLDEVVQRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I5V4</accession>
    <name>A0A1B9I5V4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_02929</name>
        <name evidence="4" type="ORF">I206_102578</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF50871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC68647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019154687.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="kpin:30171298"/>
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        <property type="component" value="Chromosome 3"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
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            <end position="120"/>
        </location>
    </feature>
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        <location>
            <begin position="166"/>
            <end position="341"/>
        </location>
    </feature>
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            <begin position="107"/>
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        </location>
    </feature>
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            <end position="237"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="341"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF50871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC68647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="341" mass="36978" checksum="68A5C1F564161758" modified="2016-11-02" version="1">MYVDWFLRGPINGRMEKRGGSGQGITTTRAASISYGAGPPASTETKWRGIGNEPKIAGSTGGFIGLIAGLVIVLILVTFIGIYLWNRYRKRLPSKKGSHSGMLNPLPSLSFSRPSTSDPYAQSASRAFEMDQDLDLGVGETPKASKFSFTEPVYTRQRSSEWELPVEDPFSSGYDGEDGGKGKGRGYIDVELPNQPDEVALPLRNKTTRPISPASGHDTRSRSDSLNSVSSFVSTHSKGTIRGKGKGRANPLESNSSRIINPFDNPYDESRLSPIPFRRADSMTSLSSTESDGARKDTKRTQGGTPTGSSGGEDSEHSVRVSQIREGSRFVERFESKESLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I5W3</accession>
    <name>A0A1B9I5W3_9TREE</name>
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        <recommendedName>
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        </recommendedName>
        <alternativeName>
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        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_02939</name>
        <name evidence="8" type="ORF">I206_102587</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IML1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="OCF50881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC68656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="STRING" id="1296096.A0A1B9I5W3"/>
    <dbReference type="GeneID" id="30171308"/>
    <dbReference type="KEGG" id="kpin:30171308"/>
    <dbReference type="OrthoDB" id="39497at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="DEP_DEPDC5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GATOR COMPLEX PROTEIN DEPDC5"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00610">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1481"/>
            <end position="1557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1587"/>
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    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1988"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="766"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="808"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="829"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="864"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="910"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="972"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="989"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1598"/>
            <end position="1612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1613"/>
            <end position="1630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1875"/>
            <end position="1895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1999"/>
            <end position="2011"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCF50881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC68656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="2011" mass="223098" checksum="9068D9E44B62050F" modified="2016-11-02" version="1">MFQSLSLADFTNIGRASSPRPVNIRARSSTIVGTGSVPAGSTQPGPPSIDISASSFRITTNPFPGPSAASQALADQLGTSGSSSSAKRSKYVAGGVSNGNGTGHNRIASWPSPPQPVITHMPSAPAVPTRANIEGGVLDLSLVDKDSVALLLYTYKPPTNTLNGPNYPSPLPSTSNVTNGPSSQVLLNYAALAWEAKPGDYLEIRQIHRRQPEQPSRILGPEGEAYRKKKDSGSTALNGVKLGKGRDGYVFRLGDDVPTASAHQIQVPDSVATAFGFQQRLEVEVRRITEKDSAHTDYVEFYFSQYLGRADMWRLGMSLEGMTLHVGEKVSLAGGAVRAEVNFIIRSEKDPKTGKMRDKRYSSGIATAKTKTIFRSKSAQVYLFIQLCEETWEFDEDGERYIEKVVHGYLPDLFARWAEKGTSHVVTIIFFARIYYDEEDVEYLRKHDMAGSLTKDYAGRACKDFFKVAVDLERRNDWTQALPEIKRQLEGTERELMLDYHFQLMKGAHQDGDEVKIVGRWSFAYEGNALEAINLALNPFDEHHVDRDLSRTGLSITIITPGTGHFAVDKNLLRLTTERMVDHGMSVDFVCLTKMPLHSVPLFSYVSHRPRGPGAEDNPSNARQKAITPDLLYFDAHMSHIKDTELADCYSLPSWVSASFYAVTHDKPFRPDRFIPRCKMYEIQMLGILDHNLTTVIVPYIDIDDMPMPRRPLTMEDRKTIRDDFDQSIFGEISQPPHVMSKMNSPQLGSTPASFPASYQSARLLAEKDRHEKERSNSMASTTRPKSIGGLGGGSKLSPIKAMIELEDSHPLGRKRTEFRSASPAPSTLSLGRGLRSDSLSRPNTTVAPPTPNVHTSSPLLIASRNSSPIATTRSASPLPPPMNDTSTEVRSRSPLPLNRDASPSRESLKSTSQVDSGASTPRLTPAKKLNTKSSKSSFASRLGATWLFGGLTSARSQPSYATPAIETITRTDVSSATGNRPQSPAPPSVLSTTRSASSSSKPSNPRSRSGTRKGSVPPKPKMPNPDTMITPSTPSPSKDKPQNPNLPTPITQPVPISGTTSRLRRSHTVEEDPISRSLRNSRGIPGVSGQSGGAGGISKSFEDSSWRNRNNALVQSSRHFTVNPCKPSAETIDRVRDAGGRRWRFVLPKQAQQHIVQWPSLLAPACLPLTTDFLPTQKQSDELYNTGTYTVQCYLEDGAFLIRSDSAQENLPLAMMREMVSQRLSQNFQVIVLPHDLNEPGVVRPMPIHLEKDSDIGVELVSGGASEVLKNGRGAIWMSWANHIHRLLFHPTRQEIIVHWMTRKVSHSTDPVKYRCLVWPVGMKGYQPAEAVFNYPDVNTKINYNHLDHLINGERRTLDPLRYWRTRFILIPSGKEVISFPGLIPQNEHLNQTDLLWLGAQKVIETLNRYLLKSQNGTPQSPLRIVTTTFDPSTCVLDEELMMDLERQISNKEKPTNTGSEDKRLEGMTLANVAELMCQPGNGLIIRTRWWEARQHVQSFTGAQFCEWLQNSFEDVTSREKAAEWAESLLEKGLIEHVTNSHGFLDYWHLYYRLREPYNSMSKSSSKNKSWFGTTTSRVTSASATITKDLSKDEGSDQTNGTSAAINGGTMTASSSTNTVLSNTSNGTTLPNPAVVQASLPSTTPPGARALLAKMYEGPKLNSPTITATGRVRKRKVKMSQTRVLDLDPNKKSDRAEVAILHADVVHNARNAFHFELNWLGVTAALLEELRQKLSAQAERYGLRFVETPVEQLIDMPLKCAYRTAIPITLSVAPPIIPDLHERLLAIGHGTGQVENYFEYCILTKKFGFVLDVEASNRYPENIEVEYSYRKTKFDYSQFVHKSGLALIQCLTNSKGFLWSDNRLIISSNNSSISSRRTVPNNGNNNNNGNLDYGNGNGNGNGFLNKLEEVKSLRKELEEFVGNSNKLIEFYQEMIPPLPDNDIEDKIEIEIPKSINIDKSLVEYQDEEVLISPSLNINGNFLKDKENKMNRSRSNTKTTEKEIKEALKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I6E9</accession>
    <name>A0A1B9I6E9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_03154</name>
        <name evidence="4" type="ORF">I206_102800</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF51088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012307.1">
        <property type="nucleotide sequence ID" value="XM_019154904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I6E9"/>
    <dbReference type="STRING" id="1296096.A0A1B9I6E9"/>
    <dbReference type="GeneID" id="30171523"/>
    <dbReference type="KEGG" id="kpin:30171523"/>
    <dbReference type="OrthoDB" id="2563978at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="714"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="794"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="536"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="714"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF51088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC68864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="826" mass="89140" checksum="F6F2AD814948FF2F" modified="2016-11-02" version="1">MPNSSRLGGLGIERRGGTAPNGQVLADWQTYLSYVTTINDTPYTVTTIANLPLTYYGPSIPLGDGWTYGGLTSPTDIDQMIPPMTNSVQSPTTQIEITSPTFLTAFSSTTPSATPPVSSPMTSSSINIQSTTSITTSSSTRLSTRSSAVPPTSSSNHGNSDSVSTFFPHSVNDNPTTAPSPIPTNTNTDNFNLLAPLLGALIPLVLTILILLVIFCVYHKNRHSRDSRFFGLFSTQKRSSVQPDPTSNTRTGKSKETVNVAGTDEDGVKSPNEKSALLPGWTAQHHRLNSDSSSQEIITETNDGSTELAKRNETLLQRLDLGLGWLIPGNQSSLSKKDKESRVVSGNTLEKGHGSNRSFFSPSAMANAATAGLVGLSSKKDKRNTAQSSSAGTYERVLDDDQLFFSVPRPNRSSEESRTSQLDARSATGGLTIPHSPKGKALDSPAEIVNMASGSFSIGIPYTPNTEVNDISIDLSEIGADRRRARWSEDSERIRFPAPPGAGLGIYDGGTFGRQPRIREDERRESYMSGETEYYSAPSQSSSSHIPSTGIPIPRDAEEYRHVSVSAFGSHPSTPTRPARFSRPGSMSSTQQPSQRDLSPVKLISPLVSPRKAQSAHPNRPISGVGSTFHSIRNLFTFTPASSPDIRNDTSVSRDNRKSYVGQPIIDERFEGTNRKVSEFGEPLKQGALVASTVVSPRPSHSSERASLHLSIPTTQYHSHSSHTTSGSSNDATEASHEPALRGKRSKGTLIKASKITVIQDQSGPSNLGRRSIQVDDEDREWEWEDNIDEFLAEGEELPPLTPDGNGMRDKGLRDSLIGRWSGSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I6H5</accession>
    <name>A0A1B9I6H5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prefoldin beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_03196</name>
        <name evidence="5" type="ORF">I206_102843</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF51130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC68907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019154946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I6H5"/>
    <dbReference type="STRING" id="1296096.A0A1B9I6H5"/>
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    <dbReference type="KEGG" id="kpin:30171565"/>
    <dbReference type="OrthoDB" id="248120at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Prefoldin subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="6"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="77"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF51130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC68907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="134" mass="14896" checksum="5D37EB553AEB41CC" modified="2016-11-02" version="1">MADTKVASLQAQLQQSSMAFQKLEAELAGVIEARQRLDSQLSENELVLKEFTQLKSHNVVYKLVGPSLVPQDSNEAKVNVEKRLDFIKSEIKRVEGQLKDSEEKAAKKKDEIMGLQQQFQSLQGPNGGQQAVQG</sequence>
</entry>
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    <accession>A0A1B9I6K2</accession>
    <name>A0A1B9I6K2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_03218</name>
        <name evidence="4" type="ORF">I206_102868</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF51152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012371.1">
        <property type="nucleotide sequence ID" value="XM_019154968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I6K2"/>
    <dbReference type="GeneID" id="30171587"/>
    <dbReference type="KEGG" id="kpin:30171587"/>
    <dbReference type="OrthoDB" id="546212at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007657">
        <property type="entry name" value="Glycosyltransferase_61"/>
    </dbReference>
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        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961:SF38">
        <property type="entry name" value="PROTEIN O-LINKED-MANNOSE BETA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF51152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC68932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="616" mass="68595" checksum="68F92CFEBAA6DFA3" modified="2016-11-02" version="1">MTSGDYEPLPTSSTLPTYPPLPGPPFRPRLHKKQITLILILKYVLGGCASLVICHFVLIGAFPNSSYTKYTTNFRNSHVEQSSYASAAASVQGVLDSIDSSAGQPGTFFRDSFPLKTMIAFWELAEKEVKARSLDTCNGQLGRELIDAYHSSQLGYCVPPGDSLTDFIIDPIRNDSRAPHLNTEDVNLVEGTSIFCSTVHRAEFSRWWPYPAAPCVSKNLRTIPNSQSERKFGAAGCEITEEGIKLNNEMGGERFLGTDTEGVAPENDQCKERIERTLLVIGRQDQWNPFHVAEDLITTLVSVFVAVQTAPALITSRVQLVFVEGFGMDQNHFTPLWDRIGAWAPRRLSLDPWIEGTCLTNAIHSVGAGASLLSAMGVGTSYSCASTITWAASHYYRHLFGLLPPSLSLPANLLESYHDNERPRRPINVLWLSRAKLDDYAQKHNDWSNWRDVRHITNEPELIQKFKTELEAMCQESLKSREFGQTGCVYEDATEIPEGWTLTSPETLKDTDPLPIRFMSLDPTVHALENQIHYVGHSTILVSSHGGALGLSLFLPPGDGTVIELQVQNVVGNYHFQHMAKECGHNYELLHINRQVDVNQVWDSVKRWIGKIAISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I6W6</accession>
    <name>A0A1B9I6W6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MHYT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_03306</name>
        <name evidence="5" type="ORF">I206_102954</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="OCF51239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="kpin:30171675"/>
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        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005330">
        <property type="entry name" value="MHYT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35152">
        <property type="entry name" value="DOMAIN SIGNALLING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G11310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35152:SF1">
        <property type="entry name" value="DOMAIN SIGNALLING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G11310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03707">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="610"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="644"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="679"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="722"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="MHYT" evidence="3">
        <location>
            <begin position="618"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="1233"/>
            <end position="1364"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1235"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="1326"/>
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            <begin position="1352"/>
            <end position="1363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF51239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC69018.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1414" mass="155648" checksum="FFE1719AAEFD9715" modified="2016-11-02" version="1">MVGPSLYNNPRNAVASSSQQTLPPKPIGQEPSLPARRLSRHLRRRLLNASLYLVSAFLLPTLASANPLPPSILSITERRHPSSTTPSLRQDEISLLSTVNQLASTTEGLLRHYQQRRDNSSSSPIIVIAEYDPALQAYRMPDDYVELRQQFHAGFIVLSYAIAFVGSLCTLELLVRRTTNSGWRNQLLLASAGICFGAVSTFAMHFVFNNALSLHHPWMDKNSYPALYLSYDPGFTVLSLVVSCLAMTMAFFVMGTQIRDWLIWPGFRKKGKPGRRNSPSKLEADDYGKWKNSHKKVIRRGTMGVGALFAQASNAAKWSLMDLEGSGELNGNNRPSLKDKLGDYTGKTSNWKEEVQGMYSPMKAQNEGMFEDDEALKELDFRLGKDAVRQELERRAGATTPTSTRASQNGSLHHSTSSHPITPLPVIYAPSSRRSSVTSGIPLTSPDVFTPGFNFPPRIEPDYFDHANLASPAAGGQKVRAPSPTFGESTSNFQPERRRASLPTNVLTTHRERPSYSGPSTTLARIQSLPEGDLEPSSSGSVSSNEEEKNVSKISPTSITARLSSFTGRTEATSERSQKRVRLKTTSTRWTRLGMFLGFDVVTPTEVMKIVITGTIAGFGVVGMHYIGQASITGLPYIAYRPAYVVGSIIIACGAVVIALYIMFIMLRPKLKHTWISKICVAFILAIAVTCMHFCGMMGTTYGWPAGKGISRHNKLTGTNVVITGIVAALAFSACIACAVFFLLHSLNLRRERARRRRVVIAAVLLDDRDRVLVNSIDGMLPMCDIASLTGGGDLPDTKRSFIQSVSSDSTVLGMDLTTGHDAFVSALKLSWTWKNPSLVPLQSTSSNDGRSQANESILQATFSDIRRGSMLTTNTTTGTTGSRPPVSLTKFLERFTISSCQLAVRLLGQTDGISRLGVLYDQILTTGWVKLNNSNDTVSKGQLIFLVRRVASTAERLDLESRHFIFADSQAVAQALHKTLSVPLNHTMPLLDDMRTFCDSTLQSRLQPGKLYAGVAVVQATPFDGLRILLEKDMRSQLPLREVCDLGIPCQDENELSGTVEEIGEALALLEGMSILSIMTRNMTNDQEQAQGNQILSKRLMNLLKSLERAIVPMLDEMLTSEDMTHILPRLILHPILIPLTPGGSKRTISSYIPPYAIIFYANYDAAVNTFTDKWLPFSLFRAQNACVMAPKILAASKMDQLYTAEIEGNGIGISNSTTIVGRRPSKVQFDFNQSHSQSSHHQQSQQQLQQQHEISDIPKIKNDENSDVVGGEMFSNFTFPPRTSLDEKEKEKEKEKDKSISTILQNPNGNSNSYGHINHGQRIGSISNNYNNQQGGIGRKSSLARSRYNSTGGESSSFSGNGSFGGFSGQQYNNNNHNSNHQIDFKCSSTGVAIWEPDWLLQLLRTKLRAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I7B8</accession>
    <name>A0A1B9I7B8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lactam utilization protein lamB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_02045</name>
        <name evidence="2" type="ORF">I206_104514</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012550.1">
        <property type="nucleotide sequence ID" value="XM_019153810.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A1B9I7B8"/>
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        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
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        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005501">
        <property type="entry name" value="LamB/YcsF/PxpA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30292:SF0">
        <property type="entry name" value="5-OXOPROLINASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30292">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBGL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03746">
        <property type="entry name" value="LamB_YcsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCF51331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC70563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="28497" checksum="695603F6AE7C31C3" modified="2016-11-02" version="1">MVNSTGSSSQTLIDKVEINVDCGEAFGSWEGGPDEALMPLIDAANVACGGHAGDPVIMRRTVALAKRYGVKVGAHPGFPDKAGFGRRVLVMSAEQAYAEMLYQVGSLKVFLDEAGVPLNHIKPHGMWYIMMQDNEELNDASMRAISHFKVPVYGMPNTLHESGAKKYGIPFIPEAFVDVNYDNKGVLLGVPGSRKMTTDDIYQAAASLAKKGLVPAVDYSLVDVGVKGQPFTICLHSDFKTCKENIAAARKAVDEVNNELYNSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I7V9</accession>
    <name>A0A1B9I7V9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Essential nuclear protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_02332</name>
        <name evidence="4" type="ORF">I206_104793</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the bystin family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC70841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I8J7</accession>
    <name>A0A1B9I8J7_9TREE</name>
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        <name evidence="4" type="ORF">I206_104896</name>
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        </lineage>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="OCF51721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC70944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Transcription factor tau subunit sfc7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GTF3C6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019481">
        <property type="entry name" value="TFIIIC_triple_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21860:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="127"/>
        </location>
    </feature>
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    </feature>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF51721.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC70944.1"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <sequence length="377" mass="42243" checksum="15253328B184AAC0" modified="2016-11-02" version="1">MLQSSDEALQFLAEGQTLLGEGWTHVNDFDNLKENEYEEEEEEIYVTMDLGTTIDSKSLQNESQYQLVGLDTPLTFLKLGNQIFQGQITPLIGDEVILGLIRDSDNPHEPTHPPIYSTNHRLTFRAIAFESRTISNSSIQPTTSIPSVLWNSDKEKTYKEDEAGPSSHHFLSKSNNEKLGYSSEEPRFNSSVGGVSNKPRTQKARLIIERTEDLENFNLESIKTSQKVELGPEILKSLDIPPSTHGEPLMLSKTELSKVISGFPSNQNQSDNIQSSNKSKKSKKVWIVGEDGKMKLQKPTFTGDSSTVDSIVNDKDKDDIEMIEQGNSEIIDSTSSREDSIQQIQAQKQDQDQDQEMIDVENDPPWTELNDGNSTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I8S6</accession>
    <name>A0A1B9I8S6_9TREE</name>
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        <submittedName>
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    </protein>
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        <name evidence="3" type="ORF">I206_105132</name>
    </gene>
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            <taxon>Dikarya</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
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        <property type="protein sequence ID" value="OCF51957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Chromosome 6"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
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        <property type="entry name" value="ARM-like"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I995</accession>
    <name>A0A1B9I995_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_01337</name>
        <name evidence="10" type="ORF">I206_103662</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC69719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013272.1">
        <property type="nucleotide sequence ID" value="XM_019153111.1"/>
    </dbReference>
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    <dbReference type="STRING" id="1296096.A0A1B9I995"/>
    <dbReference type="GeneID" id="30169706"/>
    <dbReference type="KEGG" id="kpin:30169706"/>
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    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="485"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="590"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="150"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCF52053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC69719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="634" mass="68192" checksum="BEF20082DE909071" modified="2016-11-02" version="1">MTSSSRPTRITIDPTPTNGEGITRIRDDVDNSTLYPASGSNTPWEEKRLSFASGPSTAVNTPSAGEDKPFIFPSSAPLSRMTTRVSDISEKEGKEDLDEEFKEKEETVEQYKQDELQNGIQTPAENLVGELESYPSPTRAKLSKTKQIILGIVMMSTTFVASATNNSTLLVIPSIARDLGVTELQAQWVSSAYALANGCGLLLAGRVADLYGKKWLFLIGMSLFVVFNIISGVIRNYIAICVLRAFAGLAISISLPAAFGIIGTTFTEEPGRTMAFSALALGYPVGGGPGMIFAGLIAGAGTRSWQFVFFILAGLALIPIVAGTFVIPRDPPQTITATTNRRIDWLGAFLITAGLCLFSFAITQSGLVENGWAQPYIGVCLGLSVALFLGWGFWEKWVATKTTIPPLVNMSIFSRYEWKVTSIICLSFCGYLSVSGWLYLTTIWYQNLKGDSPVMNAVHVIPAPVVGMTACIVVPLLAPRVKASYLLIIGGITTSIAQVLFAVAPVDLTYWACEFLSNCFLPFGADFTVGVGSVLISNLVNEDEQALAGALFQTGLQIASTVGVCCASLVQTSVTNQHSNLHMGLKDSFWLMAGFSWLSAIIAAITLRNVGLAKDIGTLVRGNELERQKGKQNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I9F8</accession>
    <name>A0A1B9I9F8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_01471</name>
        <name evidence="3" type="ORF">I206_103525</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013405.1">
        <property type="nucleotide sequence ID" value="XM_019153244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I9F8"/>
    <dbReference type="STRING" id="1296096.A0A1B9I9F8"/>
    <dbReference type="GeneID" id="30169840"/>
    <dbReference type="KEGG" id="kpin:30169840"/>
    <dbReference type="OrthoDB" id="529205at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF52186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC69582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="106" mass="11583" checksum="3F2DFEC27F0099F7" modified="2016-11-02" version="1">MSVLRLQAARLFRPATAPSARVWSRGYAASVHGNDPNIIEEEKQRNLKGNQDSSAPHKDHAPGWNEHLASHSEAAVKADQAGPPGKPGKDLQDATVDQTHKKHHEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I9K7</accession>
    <name>A0A1B9I9K7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NADH-ubiquinone oxidoreductase 78 kDa subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I206_01442</name>
        <name evidence="16" type="ORF">I206_103554</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the complex I 75 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013376.1">
        <property type="nucleotide sequence ID" value="XM_019153215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I9K7"/>
    <dbReference type="STRING" id="1296096.A0A1B9I9K7"/>
    <dbReference type="GeneID" id="30169811"/>
    <dbReference type="KEGG" id="kpin:30169811"/>
    <dbReference type="OrthoDB" id="10249365at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02773">
        <property type="entry name" value="MopB_Res-Cmplx1_Nad11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.740:FF:000016">
        <property type="entry name" value="NADH dehydrogenase (Quinone), G subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.740:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.210:FF:000002">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 75 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000002">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 75 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000283">
        <property type="entry name" value="NADH_UbQ_OxRdtase_75kDa_su_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054351">
        <property type="entry name" value="NADH_UbQ_OxRdtase_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010228">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015405">
        <property type="entry name" value="NDUFS1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050123">
        <property type="entry name" value="Prok_molybdopt-oxidoreductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01973">
        <property type="entry name" value="NuoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105:SF13">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 75 KDA SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105">
        <property type="entry name" value="RESPIRATORY NITRATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13510">
        <property type="entry name" value="Fer2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22151">
        <property type="entry name" value="Fer4_NDSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22117">
        <property type="entry name" value="Fer4_Nqo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Roberts A."/>
                <person name="Saif S."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
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                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
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                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
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                <person name="Dewar J."/>
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                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
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            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
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                <person name="Chen Y."/>
                <person name="Heitman J."/>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
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                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">CBS 10737</strain>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Heitman J."/>
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                <person name="Sun S."/>
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                <person name="Zeng Q."/>
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                <person name="Mohammad A.W."/>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Abouelleil A."/>
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                <person name="Berlin A.M."/>
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                <person name="Griggs A."/>
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                <person name="Nusbaum C."/>
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            <strain evidence="3">CBS 10737</strain>
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    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
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                <person name="Howarth C."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">CBS 10737</strain>
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    </reference>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
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                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
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    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
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        <location>
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        <source>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="380" mass="43037" checksum="EDD76447DE282E23" modified="2016-11-02" version="1">MAISYPIPKWDRPEPTTHELNWAELTELPLNLFDTAEGKAELVKRVKHALEVEDLGFWSVTNTGFSEEEIEQQFAIGQAFYKLPLEERKSNSIDAANGGYLGYRAAYERTINGTDVLDNMELLNIPKYTKDFSETPRHDIIKAHEAEISDFHRRCWYDVARKLFVLFALALELDENYFVDRHDYEKISQDHLRYMMYHPRSVEDDAKCNNLWSWAHTDYGSLTLLFSQTVSGLQVKFSDGTYRDIKPKKGSIVVNVADTLSFMTKGYLRSTVHRVTRPPPDQAHIHRIGVLYGCRPNDDVPVVVAPSPFLQRLGYLTPEDIAAASNEKNAVTAGEYVAARVKAVHASSTYGNAPGTKFKHGNLEVLENFGDVKDGSKTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IAY2</accession>
    <name>A0A1B9IAY2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_01877</name>
        <name evidence="5" type="ORF">I206_103119</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013803.1">
        <property type="nucleotide sequence ID" value="XM_019153642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IAY2"/>
    <dbReference type="STRING" id="1296096.A0A1B9IAY2"/>
    <dbReference type="GeneID" id="30170246"/>
    <dbReference type="KEGG" id="kpin:30170246"/>
    <dbReference type="OrthoDB" id="10261408at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="3">
        <location>
            <begin position="192"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF52584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC69183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="584" mass="65955" checksum="EBF1C1C207974BA6" modified="2016-11-02" version="1">MTPSFLRKRDRPHQLNSNNKHKPIRPSLSLPDLTTPLLDISSWEEVPPFQFQLKSPISPNTPLNISNNSNNPNSIDGIKRKMSFNKKPSLIDSSSKGKGQNSFPQFHRPFTPKLINHVNLNFDIINNEDKEDFRKSRIGWSSDHPFSQPIYNYQQAPSSWNKLSQSGIEGSGPSRDSLHRVISRRKGRKKGTVGKLNIAVVGGKGVGKTSFINLLLSTLNTVEYPTTTIPLNSTSKLKSYTAISTIDERLLVRIIDTPGLDLRLNDELATKARMRGVGGLIRLLEDRFEVMCEEERKIRRMTGGEEGLIHLVIYLIDAREILHPQSTNGLDIVDWSCVGLFDDDQPAFKSTAENEAYDPSSSAKVSDAEIDIIRKLSKRANVLPVLTHSDSLTISELNKVKFVVRRDLGDKKYDIPGRGFGIFNDFDEITRKSMESTILSETEDQRPPTPDSINPTINPIDEIEEISLELPYHIFLPDHTIFNSKLTEVITTTKTKGSSIITTTTTTSTISNSTSLNDENLEGKKRIYKWGQAEIFNPSHNDFNLLKENILGENSKILIKTTREILYEAYRTERLLNSKRQTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IB59</accession>
    <name>A0A1B9IB59_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 19">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="14">IMP dehydrogenase</shortName>
            <shortName evidence="14">IMPD</shortName>
            <shortName evidence="14">IMPDH</shortName>
            <ecNumber evidence="14 19">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">I206_00186</name>
        <name evidence="22" type="ORF">I206_101140</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="22" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14 19">
            <text>IMP + NAD(+) + H2O = XMP + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="14">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="14 19">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homotetramer. Seems to be able to form heterotetramers composed from more than 1 of the 3 IMPDH gene products (IMD2-4).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14 18">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="14 19"/>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF52885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014104.1">
        <property type="nucleotide sequence ID" value="XM_019151966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IB59"/>
    <dbReference type="STRING" id="1296096.A0A1B9IB59"/>
    <dbReference type="GeneID" id="30168555"/>
    <dbReference type="KEGG" id="kpin:30168555"/>
    <dbReference type="OrthoDB" id="416622at2759"/>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04601">
        <property type="entry name" value="CBS_pair_IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chromosome 19 SCAF14664, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
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    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
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    <dbReference type="NCBIfam" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911:SF111">
        <property type="entry name" value="INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
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    <dbReference type="SMART" id="SM00116">
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    <dbReference type="SMART" id="SM01240">
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 17" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14 19" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="5 14 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14 15" id="KW-0520">NAD</keyword>
    <keyword evidence="9 14 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 14 16" id="KW-0630">Potassium</keyword>
    <keyword evidence="7 14 19" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="20">
        <location>
            <begin position="140"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="20">
        <location>
            <begin position="202"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="14">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="468"/>
        </location>
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    <feature type="binding site" evidence="14 15">
        <location>
            <begin position="296"/>
            <end position="298"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 15">
        <location>
            <begin position="346"/>
            <end position="348"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14 16">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
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        <location>
            <position position="350"/>
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        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
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        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
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        <location>
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        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
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        <location>
            <begin position="386"/>
            <end position="388"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
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    <feature type="binding site" evidence="14">
        <location>
            <begin position="409"/>
            <end position="410"/>
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        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
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        <location>
            <begin position="433"/>
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        <ligand>
            <name>IMP</name>
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        <location>
            <position position="480"/>
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        <ligand>
            <name>IMP</name>
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        <location>
            <position position="535"/>
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        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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            <dbReference type="ARBA" id="ARBA00022749"/>
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            <dbReference type="ARBA" id="ARBA00022755"/>
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    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_03156"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
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        <source>
            <dbReference type="RuleBase" id="RU003927"/>
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        <source>
            <dbReference type="RuleBase" id="RU003928"/>
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            <dbReference type="PROSITE" id="PS51371"/>
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            <dbReference type="EMBL" id="OCF52885.1"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
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    </evidence>
    <sequence length="554" mass="58707" checksum="0A3EE6EA59D9532F" modified="2016-11-02" version="1">MSQSNGHASSSANPNAPVRPASLLKASDALSYLDEYPRGDGLSLHELMDSRKNGGLTYNDFLMLPGHIDFPASVVSLQSKVTKNISLNSPFLSSPMDTVTEDRMAIALALHGGLGIIHHNCSAEDQAAMVRKVKKYENGFITDPVCLKPDNTVGDVLDIKARFGFCGVPITETGKMNGKLVGIVTGRDVQFQDSEAPVRSVMTTDIVTGSAGITLEQANNLLRDSKKGKLPIIDSNGNLVSLVARSDLLKNQNYPLASKVPESKQLYCGAAIGTRPGDRDRLKLLVEAGLDVVVLDSSQGNSIFQIEFIKWIKSTFPKLDVIAGNVVTREQAAQLIVAGADGLRIGMGSGSICITQEVMAVGRPQGTAVYAVSEFASRFGVPTIADGGIGNIGHIAKALSLGASAVMMGGMLAGTTESPGEYFYHEGKRVKVYRGMGSIEAMEHTQRGSVASKNAILSTAADNAATARYFSETDSVKVAQGVSGDVADKGSLSKFIPYLYTGLQHSLQDSGVKSVVDLQNGCRAGTVRFELRTASAQLEGGVHGLNSYTKRLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9ID05</accession>
    <name>A0A1B9ID05_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_00585</name>
        <name evidence="10" type="ORF">I206_100742</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC66835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019152365.1"/>
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    <dbReference type="GeneID" id="30168954"/>
    <dbReference type="KEGG" id="kpin:30168954"/>
    <dbReference type="OrthoDB" id="419616at2759"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF15">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="63"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="497"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="497"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCF53284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC66835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="544" mass="59403" checksum="4D1ACC7017A79400" modified="2016-11-02" version="1">MPLVQRTSSPLPRSTTDGQSGPPVDQLQIPSPTQTYLSPPSASYISTSTPTKSKHKTPVPYLKILPLLLQRCSEGLTYAIIFPYINQMILEMGVEEKSVGVWSAIAESMMMATEAMSAPFYGPIADRYGRRPVLILLNAMWGVFGIAFGFSKTVLTIILLRAALGLLAGCGVISRTMVGELCDKSNRIQGFAVFSPALVVGMTIAPVLGGFLAKPSGRILPASWSLFVNYPYLLPSLMTGCGAIFAGILCMILLPETLQRSKMDNSLERHSEKSSNSGLRGLLKYEPFLNILLLYGMNNAVMFSWEAIYPLFGFTSKSLGGLGLSTQALGLVLGFSAGLSILMTIFVFPLLHGSLSEATCLRLCLISYPCAIIFFPILWALSYPVSGDNLPISVWIIMSIQMILRRVGDFATTQLDTLILDSIPGPEHLASANAISFSVAAIGRAVGPFIISWFFSLSTRFPSPFSPGRHMVWIIFVILCIPSLYLANRLLSDIDHTSGKEETSNEEERYELMSSNQNDPSEQVEARGTSIEVANDDLMRYRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9ID63</accession>
    <name>A0A1B9ID63_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADH:flavin oxidoreductase/NADH oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_00860</name>
        <name evidence="7" type="ORF">I206_100469</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014774.1">
        <property type="nucleotide sequence ID" value="XM_019152636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9ID63"/>
    <dbReference type="STRING" id="1296096.A0A1B9ID63"/>
    <dbReference type="GeneID" id="30169229"/>
    <dbReference type="KEGG" id="kpin:30169229"/>
    <dbReference type="OrthoDB" id="1663137at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051799">
        <property type="entry name" value="NADH_flavin_oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43656">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43656:SF2">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="5">
        <location>
            <begin position="17"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCF53555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC66566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="475" mass="52048" checksum="3E4FB53711DECBC4" modified="2016-11-02" version="1">MRGQTNMVLDDVRAISQPLALPNGVVVRNRLVKAAMAEGIGLGGGTPRKGHSNLYNEWAKGGWGIIISGNVQIDSRHLASPHDLTLPSHSSTLKAYTKLASTVHETATSPLLVMQISHPGLQSSSTINLSRWPWEAAIAPCRDRPTVSDGPIGWIWSRAVWPVKSRQIVKSDEWLEIVKKFIDGAVLAEKAGWDGVQVHSAHGYLLAEYLSPLTNPRPKPLPNVPDYIPIRLHLLYLILKGIQDNTSKSFIKAVKINCSDFVQGGIDEKQATQIVKTLISWSILDIIEISGGTYSSPAFASPESIKSPSSTSSRSTRQSLFAHFTSTLLPFIPASPNGPAILLTGGLHDRNLIVSSLKNKACDLVGIGRPACLYPHLPSKIILNENISDEQARFGGYNIPGSKLMKFILGGSDTKNSIKLVGAGISTMWHEWQLCRIGRGVEPDLNMHWLKGLIVEELWYEVILGLPVKLWRSWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IDU0</accession>
    <name>A0A1B9IDU0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_00973</name>
        <name evidence="3" type="ORF">I206_100352</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014886.1">
        <property type="nucleotide sequence ID" value="XM_019152748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IDU0"/>
    <dbReference type="GeneID" id="30169342"/>
    <dbReference type="KEGG" id="kpin:30169342"/>
    <dbReference type="OrthoDB" id="2567788at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628618" description="Apple domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF53667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC66450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="22298" checksum="4A7760697761BB84" modified="2016-11-02" version="1">MLSILIFSIFLISSINAINLPRQIEKIGSPVYIACVSDSKISSLIQNLPINATTKEECSSKCSLSFENDLSFFKQNTNECYCTFLNDSPTSDEIVYSIDEKGNCRLNDDTSVEYLKSLYKISTCILPPISISSSNFTSNNPVECLINCPNDTTQSIAIRPEYNDDSDKFQYECSCFDNNQITGGQQLDCGFGIETIYVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IDV9</accession>
    <name>A0A1B9IDV9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycerol-3-phosphate dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="9">1.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I206_01126</name>
        <name evidence="14" type="ORF">I206_100199</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 9">
            <text>sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.8" evidence="9"/>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019015038.1">
        <property type="nucleotide sequence ID" value="XM_019152900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IDV9"/>
    <dbReference type="STRING" id="1296096.A0A1B9IDV9"/>
    <dbReference type="GeneID" id="30169495"/>
    <dbReference type="KEGG" id="kpin:30169495"/>
    <dbReference type="OrthoDB" id="10263760at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141152">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000004">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000365">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017751">
        <property type="entry name" value="G3P_DH_NAD-dep_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03376">
        <property type="entry name" value="glycerol3P_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728:SF8">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(+)]-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="2 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal" evidence="11">
        <location>
            <begin position="54"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal" evidence="12">
        <location>
            <begin position="245"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="59"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="321"/>
            <end position="322"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
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    </evidence>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCF53819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WWC66298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="394" mass="42225" checksum="4A6C77C4C650DCA3" modified="2016-11-02" version="1">MSAQSSAPTTPDVPAKDFSDLEISSTVTTPAATRPSSPVPAALPPSPLPSGKHKICVIGSGSWGSALAKIAAENAWKRNDEFHSEVRMWVREKIVNGKPLTHVINRTHLNSRYLPDIKLPKNLVATPHLKDVVKDATLIVFVVPHQFLHTVLGELSKPGVLHPQARAISAIKGVEVNGTDIETFASLIEGRVGTPCSALSGANIALEVAMGQFCETTIGCPSHEDSLLWKAVFHAPTFRVNAVEDVNGVSLGGALKNIVALAAGFVDGLGLGGNTKAAILRIGLSEMTEFCLEFFEGSQRETFSNESAGIADLITTCYGGRNRKCAEEFAKTGQSFDVIEKKLLNGQKLQGTATAEEVNNFLRARKRVHAYPLFEKVYLIAFQGLPPKALVQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IE26</accession>
    <name>A0A1B9IE26_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thymidylate kinase</fullName>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_00987</name>
        <name evidence="12" type="ORF">I206_100338</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymidylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014900.1">
        <property type="nucleotide sequence ID" value="XM_019152762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IE26"/>
    <dbReference type="STRING" id="1296096.A0A1B9IE26"/>
    <dbReference type="GeneID" id="30169356"/>
    <dbReference type="KEGG" id="kpin:30169356"/>
    <dbReference type="OrthoDB" id="425602at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:dTMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006227">
        <property type="term" value="P:dUDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01672">
        <property type="entry name" value="TMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000679">
        <property type="entry name" value="Thymidylate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344:SF1">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate kinase-like" evidence="10">
        <location>
            <begin position="15"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCF53681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC66436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="220" mass="24792" checksum="B1825B0A9EA7CB12" modified="2016-11-02" version="1">MSDPSSSRRGAFIVFEGLDRCGKSTQVARLVERLERKGDRARLQKFPDRTTAIGKMIDAYLQSKAEMDDHAIHLLFSANRWECANAIRRDLENGITVIADRYAFSGIAFSAAKGLPFDFCLNPDKSLPLPDLTLYMTLSQEEASSRSQFGEERYETVSMQSATRQQFTLVAQEVKNRHGKERWVEVDARGTIEEVETRIEGIIANLTSQGVQGEIGKLWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IET0</accession>
    <name>A0A1B9IET0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA mismatch repair protein PMS2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_01107</name>
        <name evidence="7" type="ORF">I206_100218</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019015019.1">
        <property type="nucleotide sequence ID" value="XM_019152881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IET0"/>
    <dbReference type="STRING" id="1296096.A0A1B9IET0"/>
    <dbReference type="GeneID" id="30169476"/>
    <dbReference type="KEGG" id="kpin:30169476"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03484">
        <property type="entry name" value="MutL_Trans_hPMS_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.100:FF:000001">
        <property type="entry name" value="Mismatch repair endonuclease pms1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000017">
        <property type="entry name" value="PMS1 homolog 1, mismatch repair system component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="entry name" value="MutL, C-terminal domain, regulatory subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF52">
        <property type="entry name" value="MISMATCH REPAIR ENDONUCLEASE PMS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="5">
        <location>
            <begin position="231"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="4">
        <location>
            <begin position="771"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="403"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="454"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="631"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="667"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="481"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="513"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="544"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="568"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="586"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="602"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="632"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCF53800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC66317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="993" mass="110282" checksum="54F7BFF4A41872C8" modified="2016-11-02" version="1">MGGSIKAIDTESVHRIHSGQVILDLQGAIKELVENSLDAGATSIDVRIKDNGLDSIEIADNGSGIAESDWEYIALKHHTSKLPSLSDLYKVTTFGFRGEALSALCALCENVTVVTSTKESAPMGAIIKLGRDGRVTDSSGRIARPRGTTITLTGLFVPLPVRRKEFERTVKRELTKALTLLTAYALVPASVSLSDGRNGVRLKVESIAAGKTGKRNVQLSTDGRGSLRASVSAVWGHKALEGVQDIDLELEVDIDRVMARREGISETTQIIKVVGLISSAQWGQGRSSADRQFYFTNGRPCNLTSVARAINEVYKTFNTHQVPMAILDFQIPPQSLDINVSPDKRTIFVHSEDKLIETLKIALDEYFQPSRSTFAVGGATQTVKTIRQTQSQLLQYGRMSVDTTEPDVHNDSNNPEAEVEKAGPNQNEEYPQSMIGEDKETELDQEAADEIFVAKASNRSRSSPVIQIETESEGEYELSQPSSTGNSRPSRPSRPSSRNDVSKVQAPPLSVSRRVQQTLNTTKASWSPDKKSSSARAGPGPSTREARLDLRERLKGYASQNAVARDSDSEEESDDDAASGLAVDVDTNDDMEVDELESVASEPKEKESHHLDQSQCMEQDGEEEVIVMKSGRPPEEPLFEDDRSNSSTDTEVITARENVEAKVANEREEYTVEEDERPKTRRKSSSYRDEITTTTTQGEIKLSFNLPRLQLRFKSKGKNNLRQNIKLKNALNKVKEGALTDAAGLSNKNMQLAEEALNRVISKEDFNKMEVLGQFNKGFIIARLVHSAKINQKSEEIQETDDLFIIDQHASDEKYNFETLQRTTIIKGQALIKPRPLQLTASDEIIAIENLDILSKNGFDVKINEDALPGKGERINLISMPISKETIFDFKDLEQLLHLLSDNSITQGQMVRCSKARSMFAMRACRKSIMIGKSLTKLQMINLLKNMGTIDQPWNCPHGRPTMRHLIKIDKPTKSRSGGDRIDWKKWKRQQEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8KZL2</accession>
    <name>A0AAJ8KZL2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="4">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I206_100521</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="4"/>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058323.1">
        <property type="nucleotide sequence ID" value="XM_070202222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8KZL2"/>
    <dbReference type="GeneID" id="30169175"/>
    <dbReference type="KEGG" id="kpin:30169175"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000005">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000014">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002320">
        <property type="entry name" value="PRK01259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF46">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="13">
        <location>
            <begin position="8"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WWC66618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="328" mass="36159" checksum="F22A8B9F8FD6834C" modified="2024-07-24" version="1">MHQTGNSIKLLTGNSHPRLAEAVAARLGIPLTPCHVSKFLSLETSVQIHSSVRDEDVFILQSPSPPDINDHLMELLIMISACKTASSKRITAVIPCYPYARQDKKDKSRAPITAKLVANLLAVAGADHVITMDLHASQIQGFFDIPVDNLFSEPSMVQYIKQEVDGWRNAIIVSPDAGGAKRATALADNLNLDFALINRKHDENHFYVEKMELLVGDVKGKIAILIDDMIDTGHTVRLAAQVLHENGAKEVYALISHGFLSDTTMENLRDLPVKKLIVTNSIDQTDRINATNHKIDIIDIAPVIAESIRRTHNGESISALFRPNDLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8KZR8</accession>
    <name>A0AAJ8KZR8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin/coatomer adaptor adaptin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_101345</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_070202377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8KZR8"/>
    <dbReference type="GeneID" id="30175056"/>
    <dbReference type="KEGG" id="kpin:30175056"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
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        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
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    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="6">
        <location>
            <begin position="37"/>
            <end position="235"/>
        </location>
    </feature>
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        <location>
            <begin position="659"/>
            <end position="710"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC67437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="710" mass="78950" checksum="EEF43B504F418B1A" modified="2024-07-24" version="1">MPGPSSSLPPYLVSGASSRAHHGLLTRLHEAASVQEEDEIISKEIRRAKETLAVRGQSTSKLRDTLIILLHCQMLRHRTEDNIEFAFVPALQLAEGGHTLAERRTGYLYLVERLPKKHELNLLLINTIRKDLSSTSSSCVLLALQTIAKIPSTDLAPAVIPLLTSKSLLKHNSPAVRQRTFEALLSLHQLSPNDEQFPLTMNKLLKSLQREDDMSVLAVILRLIRHLLETSAHHIHNDTERLYVIDKCLEAARQNEVRYEGQIAVEVVKVLGALVERKEDFGEHDASQMVSRWVIDTMNEMGSVHGGQGAFLLEICHLANILPALAAHILAQISQLLVPDDQIATSSASPSLPSPNDHVLAIRCLGILPTSMWDGRLEEMQMGVIMHGVNSVDDTIRKLTLSLLQSLSPDLPEMILQTHFDSIRHSTDLSLPMSLANGLTLKEKTQIGRNETASRALEVVEARFQNDGDGYACGVVELLEALESGNDYRDGHVWAEGVRRIQDYLEYRSPSFAHAFTTSVLESLRGMEHSSSDTLIVVFTSIACERLPLEQIPEALDYLSRIIPQHNASTQELIMVTLVALLTCLDDEIAEEKGQMVLNTIQEVQKGSSRYLKKRCQEISTIISRGFLREVKEASSTSKISDILSAIISVHARKTVKTSSSTFTSEPASPPPRADLSTSVLRYDAYQAPKQTSQNKDSYRDRYEVDEESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L2Q8</accession>
    <name>A0AAJ8L2Q8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_102169</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC68246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008181.2">
        <property type="nucleotide sequence ID" value="XM_019158435.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L2Q8"/>
    <dbReference type="GeneID" id="30175105"/>
    <dbReference type="KEGG" id="kpin:30175105"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15844">
        <property type="entry name" value="SNARE_syntaxin5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021538">
        <property type="entry name" value="Syntaxin-5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF3">
        <property type="entry name" value="SYNTAXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11416">
        <property type="entry name" value="Syntaxin-5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="272"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC68246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="363" mass="39424" checksum="F424F841F952F9E6" modified="2024-07-24" version="1">MAPKDRTSEFHSTLNSIKSRSSLASSSSSSSSSANLKSKNKDKDKESKQPLLSKDVNGSNSSKGGNKSEFGRMAGGIAKDINNTTLKLQKLAQLAKRKTLFDDRPIEISELTYIIRQDIASLNTQIASLQSYVRSQKPNSSSSGSGGGKQVEEHNSNVVMLLQSRLANMGMGFKDVLELRTQNMKASKDRTEQFMHTAANASLPPPSNNSLLFAQNGGPGSGFDRKGKSRASPIPDDGKTDFLALDIDGDRGESGVSKGGDYQQMQLVEQQNDYIQSRSTAIESIESTIAELGSIFSQLAGMVAEQRETVQRIDADTTDIAANVTGAQRELLKYYASVTSNRWLMLKIFGVLIIFFLAFILVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L2Z8</accession>
    <name>A0AAJ8L2Z8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_102538</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
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        <subcellularLocation>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="148"/>
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            <begin position="52"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
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    </evidence>
    <sequence length="505" mass="55802" checksum="3303CF36AACE811F" modified="2024-07-24" version="1">MTDLDYGKDEKVQPLDLSANEVDHEYQEYVILAEEFSGDALKKLTRKIDIRVVPQLILIYMLSYIDRGNVGNARLFGAQADTGLSNTDWNTGLSLLFITFAFGGLPSNILVKKYGPKKVLPVLLMGVGAILMGTGFSHNKAQWFSLRVLLGLFEAGMYPGCTYTLTTWYTPAQIHSRTTIYYLGGVLSGALSGLLAYGIGQLDGKHGWRGWRYIYVIEGGFTLFVGIVALFTLQETPQKTKKWLNDREKRFLLLRSKFLYGGGRMGSKDEFSLKDVIKALKSSHVWIIAFCYICNTIAVYGFSLSLPTIVKNMGFTAANAQALSAPPYVFAAFCVVGSGLFSDKYRLRAATVVFPSIVGFFGLLICVLTVKHKHLVALSYVGTCIAAGGLYCLTPALTVWTGLNTAGQTKRAAAISIVFFFAAIGGIPGSYIYLAKEAPGYPTGFGVSLGLMGFGNIIVPSIYWFYCGWINKKRDRMSSEEIHSKYTQEELEEMGDESPLYRYER</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L3B9</accession>
    <name>A0AAJ8L3B9_9TREE</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">I206_103373</name>
    </gene>
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        <lineage>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 10737</strain>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
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                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
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            <begin position="231"/>
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    </feature>
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        <location>
            <begin position="59"/>
            <end position="72"/>
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            <end position="275"/>
        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC69434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="285" mass="31006" checksum="60E96A7C4BA664C6" modified="2024-07-24" version="1">MIVCNLCGDSVLDLGSRCTKCYGRAIERPNPVKALLSSPQKRGSPDRWADKYTKSTTHAALTSSPLSNNRAATTEHRATASRPGLSRKETFDVALTAESDAELARVCGKPPSRQTQPLLLPSAKPACEGCYDVYFSTNGRYSSSKDISPGVVTTTNKYARPGQLLQGSRLPPRPAETAQELKRLMLPGTMQDVNSAAQGTVDLRPCKIMSPTRPQMALPNADRQTEQLLGFNRDLQSPPDMKKVTSVQDRVRQLNAQTTASDAGGHSPSTQSSRQPLYPLTKHNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L3V5</accession>
    <name>A0AAJ8L3V5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">High osmolarity signaling protein SHO1</fullName>
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        <name evidence="2" type="ORF">I206_102864</name>
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    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
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                <person name="Dewar J."/>
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                <person name="Griggs A."/>
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        <source>
            <strain evidence="2">CBS 10737</strain>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 10737</strain>
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    </reference>
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        <property type="protein sequence ID" value="WWC68928.1"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC68928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="70" mass="7834" checksum="89F7073E36AEAC10" modified="2024-07-24" version="1">MFDHGFDPGYVFRHPVFLVTFIIAVPSWIIAFASQAAAEAKYSSGDGRTPVVNTLWFAIWIQLAVIIHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L4B1</accession>
    <name>A0AAJ8L4B1_9TREE</name>
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        <recommendedName>
            <fullName evidence="8">Putative tyrosine-protein phosphatase OCA1</fullName>
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        <name evidence="11" type="ORF">I206_103251</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Putative tyrosine-protein phosphatase required for protection against superoxide stress.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058808.1">
        <property type="nucleotide sequence ID" value="XM_070202707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L4B1"/>
    <dbReference type="GeneID" id="30170112"/>
    <dbReference type="KEGG" id="kpin:30170112"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000035">
        <property type="entry name" value="Tyrosine phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020428">
        <property type="entry name" value="PFA-DSPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004861">
        <property type="entry name" value="Siw14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF8">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE OCA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03162">
        <property type="entry name" value="Y_phosphatase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01911">
        <property type="entry name" value="PFDSPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="10">
        <location>
            <begin position="9"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC69313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="185" mass="20775" checksum="F7C2E191B93E2ACA" modified="2024-07-24" version="1">MAKIVPPMNFGLVEDGFYRSAQPSELNFSFLEKLNLKTIIWVGAEEPSEILLSFLDSQGIKLHNLAPQVSLNPHFPPPYTDSGVVPISGQYHLPPLPPPPEPLIIQSLTLLLRPSTFPTLVCCNMGRHRTGTVVGCYRKLQRWALSSILEEYRRYAGMKVRILNEQFIELFDTDLVSITAEQALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L4Q7</accession>
    <name>A0AAJ8L4Q7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_103317</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058823.1">
        <property type="nucleotide sequence ID" value="XM_070202722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L4Q7"/>
    <dbReference type="GeneID" id="30170046"/>
    <dbReference type="KEGG" id="kpin:30170046"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF191">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="546"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="54"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC69378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="589" mass="64739" checksum="106298BCB1238B75" modified="2024-07-24" version="1">MTTSQLIRNNSQSSISSREEENIINERTSLIKNNKKFKKHHNLIGLSPIKFRLICFSLWCGTFLVAFDSTLVSTLLSEIGSEFKSSTQISWIGTSYLLSVCCFTPIYGRLSDLIGRRNSHLTGMFFFTIGTFLCGFSPSIWSLIISRGIAGIGGGGVQSVSVILMTDLVDLRHRGIYQGYVNILFGTGAALGGPVGGWISDHFGWRVAFTAQVPLLLITAGCIYTFVNFPQASSIENGSRFTDTDNEDTVSKQAQKPSWKKQLGRIDWLGSLTLALGVGTLLLSMSIKTSTTKSNGKDYKFSDPIIFGLLMISVIILCLFVLIEGYYSKEPILPLKLLIRRTPLSIAISSFTMVLGQYSILYNLPLFFTIVQSKSSSSAGAHLLPNSILIGIGSLFAGWRMRHTGKYWLLSVGCSSLMVISSIGMLFWKRLSPNWLTWIAQAPGGFGYAGVLTTSLVALMTHITRRDRSETAVATSMSYLFRTVGQVLGVAISAAIVQHVVQKDLDRDIVGPGASQIIYQIRHSTSSIPHLSPKYKDAAINAYEHALHLVFVFNLIVSILTVLSLAMVKEEEMVAPPPPQVEEQEEEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L6Q5</accession>
    <name>A0AAJ8L6Q5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_104281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059029.1">
        <property type="nucleotide sequence ID" value="XM_070202928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L6Q5"/>
    <dbReference type="GeneID" id="30172512"/>
    <dbReference type="KEGG" id="kpin:30172512"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WWC70331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="148" mass="15346" checksum="B3022F235CBF5BED" modified="2024-07-24" version="1">MSSYVPPTAASSVSCSCGSKNPSSLCTCQKEGECKCAPGSCTCPGCPVHEKKENPCTCQPECKCAPGKCECGSCPNSNKNKEKACGGDEGEGEIAVKPALVHQVNAHVPAVLPKVRKKSRNLALVVNLADVLQANALVRTAPPLPNRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L7S8</accession>
    <name>A0AAJ8L7S8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_104890</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059115.1">
        <property type="nucleotide sequence ID" value="XM_070203014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L7S8"/>
    <dbReference type="GeneID" id="30170799"/>
    <dbReference type="KEGG" id="kpin:30170799"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF21">
        <property type="entry name" value="MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="441"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC70938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="469" mass="51082" checksum="2ED4B864193C15BC" modified="2024-07-24" version="1">MSDKADNPHNTLSSSSIPQNKKKERTGFSTIGNSMTLPLTTLSSLLALQDVEDHKPKLSKISWLPDIFVFRSSILPIVLGPVLAVTLFSSGVAAASVLWGQEVGLTNNVVPLLSVVVGLLLVFRNSSAYERYAEGRKDFTALISIARNLSRNIWISVNLPPTPIDAVGPGMTKHRLTAEKRKVVRLVVAFVVATKHHLRAEGGVHHDDLKGLLPAKLAGNDIRRLKSAISNSSLRGTERYGGIVTNSPGTMTPALTTALGEGEDEESILGLSDPTTPFSPSPSMNNLVHSVNSSSYQNDKLHNEIRPNYPRNISSRLKRRPTAVRVLTPDEYNDDQETPKIYQVKSAKSSASKLDERTPLIKKGVKPDTGLIKNAELELGKMVESGLPLIIAHEISRSIFRFRKMGCLEAVGPAGMNALQAAVSGMTDQLGSMERIVQTPLPYIFCIHLKQVVSLYLFILPFTLVDAMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L834</accession>
    <name>A0AAJ8L834_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_105881</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC71922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059303.1">
        <property type="nucleotide sequence ID" value="XM_070203202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L834"/>
    <dbReference type="GeneID" id="30173070"/>
    <dbReference type="KEGG" id="kpin:30173070"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398:SF4">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="616"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="172"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
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            <end position="294"/>
        </location>
    </feature>
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        </location>
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            <end position="436"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="515"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC71922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="712" mass="79696" checksum="3CA11968C53AC9FA" modified="2024-07-24" version="1">MVVPTTSTHSQADKLSIQEKLLLSQAIHKLGAISWPAISKLISSHPCCLNRPSELFTPESCETIYMELMAGLKINVPAPDAMKPLAQTHKRLAQTYYLKRMEELQQTILQYENRFKELMIEITSLKNGEADENIRSEIRTIIARKYGKKLLDSWFPEPEVVKKAIEDGPITEEEKVKAEAEKDAKQDDQIPVDGEKAVEDEVVMAETEEPSITKGEDSEGLEKDKGNEIEDGKNAIAEVDQTTAEQVEDQDKEEEEEEEEEEEEDDDEDIKSERNAKSPSVPKSKVKTQHRRRFSPAVSVRSDLSPAPGSDLSSPPSDHATPEATEETAPKSTRSNKRKASVPLKGAPAPKRSGRRSNARVASSPAVTHEEDEAEAEAEEKDQSEEEDENVPRTRRGTRRESTRNLKASPEVVINKKSSPTVSRRAASVQSSTRSTPAPIEERRSGRRSMGTKGGRGMRDDVVSKSVREQSAALDSVKAETEAEEEEEDEDEGQEEDAEEEEEKKPIRSSARRGRPTEKERERAREKEKKEKEKEKETPVPSEKRGTRASARTVRDQSENDQASNSAADISGDFTIEGTPASTTNSIRGGGGQGFKPTPSQKSSQKLLYSLLDTISQHRNGNVFQNPVKKTEASDYHQIIKRPMDLKTIRARIKEGHITGIENFERDVLLIFANAMMYNKPGSQVYEMAQEMLKATEDHIAHFKNLQHHVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L8F0</accession>
    <name>A0AAJ8L8F0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_105221</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011764.2">
        <property type="nucleotide sequence ID" value="XM_019155610.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L8F0"/>
    <dbReference type="GeneID" id="30172239"/>
    <dbReference type="KEGG" id="kpin:30172239"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053229">
        <property type="entry name" value="NADH-Q_oxidrdct_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024549">
        <property type="entry name" value="NADH-UbQ_OxRdtase_su21_C_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019721">
        <property type="entry name" value="NADH-UbQ_OxRdtase_su21_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34062:SF1">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 21KDA SUBUNIT N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34062">
        <property type="entry name" value="OXIDOREDUCTASE 21 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10785">
        <property type="entry name" value="NADH-u_ox-rdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12853">
        <property type="entry name" value="NADH_u_ox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 21kDa subunit N-terminal" evidence="1">
        <location>
            <begin position="9"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 21kDa subunit C-terminal fungi" evidence="2">
        <location>
            <begin position="104"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC71268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="16373" checksum="E704AFEC35868AF3" modified="2024-07-24" version="1">MPVKETPAAFPVIDTDPHFTRVIRYMRPSDYLTWAGSTAIGPGLFWLYEKVDPTKASKAALRSSLRLTGFLGFAAGFMLAYQNSSARFWGWRENSDEVKKDQIELSERYAAGKPLYGETELTPYLQGVAARNSTFSQLKLHAFPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L8R9</accession>
    <name>A0AAJ8L8R9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">YCII-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_105130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC71177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013174.2">
        <property type="nucleotide sequence ID" value="XM_019154434.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L8R9"/>
    <dbReference type="GeneID" id="30171041"/>
    <dbReference type="KEGG" id="kpin:30171041"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1060">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051807">
        <property type="entry name" value="Sec-metab_biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606">
        <property type="entry name" value="PROTEIN YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606:SF3">
        <property type="entry name" value="PROTEIN YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WWC71177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="15176" checksum="B038C7A860B19266" modified="2024-07-24" version="1">MLPTRLLLTNVTRKMPLFYAICPDYSNNPSETLKNRLKVRPEHWKRAEEDKKAGILEFGRGTVPPASSSLHSDPNLPSNLQAMDGSIMFFRYKTIDQTWDRIKSDVYYTGNVWDKEKIQVGQFIKLPGEGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L9I2</accession>
    <name>A0AAJ8L9I2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_105812</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC71853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059296.1">
        <property type="nucleotide sequence ID" value="XM_070203195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L9I2"/>
    <dbReference type="GeneID" id="30173001"/>
    <dbReference type="KEGG" id="kpin:30173001"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WWC71853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="284" mass="33400" checksum="5D43ADFE6B4EC4DF" modified="2024-07-24" version="1">MNTMILEDIPYYFSYLRRTKTKCNNFKSSSSTKKHKSNFFQLSLHITNLPSTIKPLHFNYILSNHIQNNEGFKRKEKINSGINMIQIYHLPISSSSTSTSTKTKTKTKKSKFKYRGKIFNNLKTLFCISNKFIKDENENQLNSQKNLRILNKLNNPIISPVPIQQESRVEEREVINFDDHQETNLTSTHEEARLVNVNQVIEEVETVAWIHFINEESCKFSLFQFSSVEYAPSMKTEIHLRAFYELVYRAKDLLRSITIDGRKIIVKTDRFNSGLIKKFWKIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LA43</accession>
    <name>A0AAJ8LA43_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein ZIP4 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_105826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC71867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059298.1">
        <property type="nucleotide sequence ID" value="XM_070203197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LA43"/>
    <dbReference type="GeneID" id="30173015"/>
    <dbReference type="KEGG" id="kpin:30173015"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090173">
        <property type="term" value="P:regulation of synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039057">
        <property type="entry name" value="Spo22/ZIP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40375">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40375:SF2">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC71867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="948" mass="106727" checksum="0830832AB43C69A2" modified="2024-07-24" version="1">MADHRKQLQEALLSLDSLLDRLSHFEEEEINYEHLLVALSDVRAKVKDYKTKSKKKKEDKENEMAIIQNMDEKATVKIWNLTSELKQYLELTSKMGKQDVQLIASLYHTAFRLLEASTEPRPNTILTMRMLRAGASAISALTLSEDLKDAEDLVQAAAELNQTLTTSNTPDEAINNDGKEAQLKFQLARVDLEIARRGDNLALSLMIRAADDATTVAQYQEVLCKYWSVYQRLVSRTPSKDEVAVAFTTAPIEWLQQGLAVSNKMKDLGLIIPGLHKIQVCPSAVPSEGRPADRATPCLEGRNTSMYIHRRQTSDIRKQAFAYSYATPRREKGSTVRPPPADVFDALEWNDEAVASVIAQLHALSTDFPDLPFSVLQTFLIHALSQDNAYPYIGQILYEGISFGRQHFSRHTQAAHHGIVVMFEAIVKTGVQQAIDLTKAIGMQMMLLNLADKLYKINEKLEEAAQWYMLVAHPALSSAGDVRSLASLRKGALCFIQSGNLLVAEDLLKQCSSNDASTQYLFFLLAQKTNDTQVAIKAIEETMKCPDFGAGHIVAITSVAEREGDHALRIIALKALFESLQQSDVRDDLKIESMTVIRCLMQIAMSSDNTQQDKNKVGAEIVGYVDCAISLLTNDLELYISQSEPVACVYKTCYNFALDSLSEISAEILANLFNCSAQLIYWYGRLVGKDDENTLHFTRGAAMFACFSGKLFHYRDLPESLEKNLLQDQLLQYFRSVFDGLLAMPEDQKRDRLQTLLEVYQMELVCDSSDWNQVEDIISYLCSPTQTAESNSTRKLELMANLLLGYRDCPAPIVHRILETIIASCSTKTAEDVSRFSSWIRAIITLLLQEGGNSENLAKAPFYIDRVLQILRTSSETNAYPTDEVRWLSSTSWNKGLKCYHFSRYEEAQWWCQRSLELGASLPAGTIPLSKLQRQYDAMFRLDRLQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LAR4</accession>
    <name>A0AAJ8LAR4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_106637</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. ARD1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059465.1">
        <property type="nucleotide sequence ID" value="XM_070203364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LAR4"/>
    <dbReference type="GeneID" id="30175842"/>
    <dbReference type="KEGG" id="kpin:30175842"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990190">
        <property type="term" value="F:protein-N-terminal-glutamate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045047">
        <property type="entry name" value="Ard1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091:SF4">
        <property type="entry name" value="N-TERMINAL AMINO-ACID N(ALPHA)-ACETYLTRANSFERASE NATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042528441" description="N-acetyltransferase domain-containing protein" evidence="4">
        <location>
            <begin position="21"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC72673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="134" mass="15246" checksum="BA503AB0E77B7A83" modified="2024-07-24" version="1">MDIRQATIWLSLTLADLYHALTWPELSYVAVDPRGRVVGYILAKIGHVTSISVLRPYRRLGLANKLMKQSQEAMVAHYNASHITLHVRKSNRAAISLYRDTLGFEVHAMEKGYYADGEDAYGMRYLFTKPDSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LB20</accession>
    <name>A0AAJ8LB20_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein SDA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_105964</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for 60S pre-ribosomal subunits export to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the SDA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059319.1">
        <property type="nucleotide sequence ID" value="XM_070203218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LB20"/>
    <dbReference type="GeneID" id="30173156"/>
    <dbReference type="KEGG" id="kpin:30173156"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027312">
        <property type="entry name" value="Sda1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048292">
        <property type="entry name" value="SDA1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007949">
        <property type="entry name" value="SDA1_MD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012977">
        <property type="entry name" value="SDA1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730">
        <property type="entry name" value="HSDA/SDA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730:SF0">
        <property type="entry name" value="PROTEIN SDA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21638">
        <property type="entry name" value="SDA1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05285">
        <property type="entry name" value="SDA1_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08158">
        <property type="entry name" value="SDA1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SDA1 N-terminal" evidence="9">
        <location>
            <begin position="80"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="SDA1 middle" evidence="8">
        <location>
            <begin position="581"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="SDA1 C-terminal" evidence="10">
        <location>
            <begin position="770"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="544"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="747"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="548"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="568"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="600"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="611"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="625"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="747"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC72005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="819" mass="92283" checksum="80D2AB384C18BFEF" modified="2024-07-24" version="1">MPKSRASRGILLTSNLPQLQNLIKRDPEGYKEEFLTQYNHYLSLLKLQQVSSISSSNSNVTTNSSNVDKSNELFQDLITFISQVSQCYPIETKELPIQFKELLLGNSENGGQNIGNGQTVKGDLRRTVVKNLVMLRNKEIIDSIELLQILLPLLPQVPSALRGMIRHTILTDIKTSNQKTKNHRLNRVVQSLLFGMVESGMNAQVIGDKGKGKNKEKGGEAMWAVMMVKELWKKGVWNDAKTVSIVALAAFHPNTKVQSAALHFFLGSDNEDENETDSDEEEIRNARRGVKKMEHRMEVGKSGRKKDRMLAQMKRETNKKRAKHAAGLGATPNFPALELLHDPQTFGEKLYDNLHKHDKIYSLDHKILIMQLLSRVMGVHKLCVLGFYSYIIKYLTYHQLQVTLILVSLAQSVHELTPPDVLTPVIRKLAQEFVHPGVGAEVIAAGLNAIREVCRRQPWCMEEDLLSDLIDYRKSKDKGVVTASRGLLQLFREVNPGMLKRRERGKAASMGLIGNQVLAYGHSKDAADGIEGLELLEEHFASLRKEEDGDVNMGEENEDEDGKGWENWDVDSDTGSESEGWEDVSSGDEDLDISDSDDEQDRKRDREEKRKLRKSKQKNKRLGKDDEEDSNDEEEDENEDEEMDDGKSVVSVATTAISQDTKKLSLLAQQKILTPADFALLNELRLKAAKELAESGGGSGAKRKLAALEASKRHIDGDESERFLTENEILGPRKKLKSTWEEKMELVQKGREGREKFGSLKGKKQKGTPSSSTNREKARNKPLMMAVHSNKVMQKKKASLRDKQIRLRAAIDKQKKLKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LCD4</accession>
    <name>A0AAJ8LCD4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAM1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Outer kinetochore protein DAM1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I206_107532</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009213.2">
        <property type="nucleotide sequence ID" value="XM_019157573.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LCD4"/>
    <dbReference type="GeneID" id="30174229"/>
    <dbReference type="KEGG" id="kpin:30174229"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990537">
        <property type="term" value="C:mitotic spindle polar microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990758">
        <property type="term" value="P:mitotic sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013962">
        <property type="entry name" value="DASH_Dam1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28113">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28113:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08653">
        <property type="entry name" value="DASH_Dam1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="143"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="WWC73560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="265" mass="28558" checksum="9A1EA01EB7F0085D" modified="2024-07-24" version="1">MAPPHPLRRISTGSLSSLARSTDRNTSSASGLDHLTGAMVELSDEMATLSSNVQQMTALHDALGTFNEAFAGYLYALKMNAFCVEWPQAPNEQSFSRLEALEVPEPIPIASTSTLPPTPVSAPSRASTNPADMTYATQYSYTEDEPAPPVAKKPVGGIRKPSGGIPAKKGASTAAAKKKRELEISGIIDTLPLEYRGGEPAERMRMEKVIMKLMEHPDGITLKDMVSPPELPQTKVNKCLITLVAKKLVSKPIVNKVTLYKWVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LD72</accession>
    <name>A0AAJ8LD72_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">50S small subunit ribosomal protein L33-b</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_107035</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC73070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059544.1">
        <property type="nucleotide sequence ID" value="XM_070203443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LD72"/>
    <dbReference type="GeneID" id="30173791"/>
    <dbReference type="KEGG" id="kpin:30173791"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.190:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.190">
        <property type="entry name" value="translation elongation factor selb, chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00573">
        <property type="entry name" value="Ribosomal_eL33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001780">
        <property type="entry name" value="Ribosomal_eL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038661">
        <property type="entry name" value="Ribosomal_eL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10902">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01247">
        <property type="entry name" value="Ribosomal_L35Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC73070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="12097" checksum="80959BD94B315C29" modified="2024-07-24" version="1">MSLTTNRLYTKGRILGHKRGKRNSRPNQSLVQIEGVDSKEAARSYLGKRVAYVYKAKREINGSRVRVIWGRISRPHGNSGAAKAKFRVNLPAKVFGASVRIMLFPSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MMK0</accession>
    <name>A0AAJ8MMK0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acireductone dioxygenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Acireductone dioxygenase (Fe(2+)-requiring)</fullName>
            <shortName evidence="11">ARD'</shortName>
            <shortName evidence="11">Fe-ARD</shortName>
            <ecNumber evidence="11">1.13.11.54</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Acireductone dioxygenase (Ni(2+)-requiring)</fullName>
            <shortName evidence="11">ARD</shortName>
            <shortName evidence="11">Ni-ARD</shortName>
            <ecNumber evidence="11">1.13.11.53</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ADI1</name>
        <name evidence="12" type="ORF">I206_101051</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:49016"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.53"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16723"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
        <text evidence="11">Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the acireductone dioxygenase (ARD) family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.54" evidence="11"/>
    <dbReference type="EC" id="1.13.11.53" evidence="11"/>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MMK0"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010308">
        <property type="term" value="F:acireductone dioxygenase (Ni2+-requiring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010309">
        <property type="term" value="F:acireductone dioxygenase [iron(II)-requiring] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02232">
        <property type="entry name" value="cupin_ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000079">
        <property type="entry name" value="1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03154">
        <property type="entry name" value="Salvage_MtnD_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004313">
        <property type="entry name" value="ARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027496">
        <property type="entry name" value="ARD_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418:SF0">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03079">
        <property type="entry name" value="ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11 12" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 11" id="KW-0408">Iron</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="3 11" id="KW-0533">Nickel</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC67144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="185" mass="21613" checksum="F81443BA2B867234" modified="2024-07-24" version="1">MKAYVYDDIPGDQRLPHDSGNPISLKTLSELGVIYKEIPIKEDKKWEDEINSFSKERGYKNRDQITVTPEGLGEAYEDKIKSFFDEHLHEDEEIRYILSGSGYFDIRGVNEPYNERWIRISLSKGDLIVLPAGIYHRFTVDSNNTITAMRLFQDEPKWTPHSRSLPDTDERIAREEYLQQVKNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MMT2</accession>
    <name>A0AAJ8MMT2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF2237 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_103178</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013746.2">
        <property type="nucleotide sequence ID" value="XM_019153585.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MMT2"/>
    <dbReference type="GeneID" id="30170187"/>
    <dbReference type="KEGG" id="kpin:30170187"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.110">
        <property type="entry name" value="Protein of unknown function DUF2237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018714">
        <property type="entry name" value="DUF2237"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37466">
        <property type="entry name" value="SLR1628 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37466:SF1">
        <property type="entry name" value="SLR1628 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09996">
        <property type="entry name" value="DUF2237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WWC69241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="19356" checksum="A76480829DD7C920" modified="2024-07-24" version="1">MNLRGILSIPLTLSTFFTGKIQTILPNSLNTSSFGIRTATTMVLDPTKLNVLHGPLQPHTKDGDSTHPTGYQRDGYCWGIEQDPGYHYIGGIVTKEFLEYSKKQGNDLMTPRGGFPGLKDGCKWCLCVNRWKEAMFASEKLGEKVVPRVDLSSTALQALKGVSLEDLKKYEYKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MMW3</accession>
    <name>A0AAJ8MMW3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_101100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014144.2">
        <property type="nucleotide sequence ID" value="XM_019152006.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MMW3"/>
    <dbReference type="GeneID" id="30168595"/>
    <dbReference type="KEGG" id="kpin:30168595"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000003">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="6">
        <location>
            <begin position="89"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC67193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="370" mass="42033" checksum="6B6F6A8BFE0E4444" modified="2024-07-24" version="1">MSYTTTTVEQLPSKEEIINRVSRLRLVGDQEDKAEIEQQETKRIGPKYPAYLPVWDKTKFPDWEEIPHIDPGSRATKEKKNLFVSGSTHREITPAIGEEIEGVQLSQLTPEGLDDLALLAAERGLLVFRKQDFKDIGPEKQLEIVRHFGRLHIHPTMGHPEGYPEMHVVYRDPKDSTISRYVKSNEVQKISSVQWHADHVAEIQPPGITFFFALEAPPSGGDTIFASATEAYNRLSDEFKKRLEGLSVVHTNKGMLEHSEASGGPVRFTPRETLHPLVRTHPVTGEKILAIHGGHATRIYGYKQEESDYLFNFLLDVLAKGHDFQTRVHYQEGTVAVWDNRTVLHSALYDFKGDERRHVIRIAAMAETPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MP04</accession>
    <name>A0AAJ8MP04_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_103107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058781.1">
        <property type="nucleotide sequence ID" value="XM_070202680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MP04"/>
    <dbReference type="GeneID" id="96955723"/>
    <dbReference type="KEGG" id="kpin:96955723"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC69171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="97" mass="11008" checksum="F9C60A7C9F67105E" modified="2024-07-24" version="1">MGSCYSARAHPVRHTSQHYPQRGYNYPHAHSHTIRPQPKVVVMNPSPVIVGGVPRRRRTGKVVVKSVECTPGGRTVTRTHYEYGKKWKKSNKGVRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MP12</accession>
    <name>A0AAJ8MP12_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MutL C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_104542</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059070.1">
        <property type="nucleotide sequence ID" value="XM_070202969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MP12"/>
    <dbReference type="GeneID" id="30170443"/>
    <dbReference type="KEGG" id="kpin:30170443"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF47">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="5">
        <location>
            <begin position="221"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="4">
        <location>
            <begin position="598"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="367"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="395"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC70591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="859" mass="95541" checksum="771F5A8078FEE802" modified="2024-07-24" version="1">MEITPLNTSTSTVIRSSLIIPSFTQILSELIQNSLDAGSDSIEVTLNLMKGNESIRVKDDGSGIGKEGLSKVGKRFRTSKTLNETNLGSVGSYGFRGEALSSIASLSLLTVTTKPKDIDKTYTKILKSSKTLYFGIDSSKTINADNGTIVNVKEMFHNIPVRQKELADSNEETLLRQCKRLIEVFALSRPGVKWLVWDEKGYGDRKLIMDIRGAKSSVQIFRFLYGNALVKRVQSIRVSAGNKRVDGFISLFGDIAKSHQHLYINNYPMGRSDLHLSIARRFANSRFGNLATSGEHDSGNVDNQKRQSPRRLVRHPIYVLNVTVPSDDVDVSYEPAKGILGYKDYGKIQALLHAVVDEYLKKNGYNRQDNGAAASPSPTKQSATTKRPHGKSPLAKSNTSHNNVNSNWDLTRPAPLSFSAIPPKDSAVSAVRIPPEQLRMNETAAIPPISPIPPISPISSIPSILPISPIPPIKDRRMNAHSSNPVWLTNDVTRIPTHPSDSSQWITNLEKSVDNGLLPFRSSAYPRKKRTFGEMQQEDEHTTTNVCADHNKRGHIRVRDDRDPANVLAARPISLESITKTPKIDVQLSKSSLAQARVIGQVDQKYISTIMPTSSKEKAVVLIDQHAADERISVERVLHDLCEGFKNDTIPITKLKHIPIIVLISSEAKILALDGILDVFGRWGIHLVLPETIQGDYAQLEVHAVPTVLASRLGKKEGVEMTRLIRGYLAILEEDIGGMKALIDSYQMNQPEINQMDGNSNLDRSHGGHENWGKEMRFMPREMLELVNSKACRGAIMFQDTLTPDQQNRLVLQLAQTDFPFMCAHGRPSMIPLIAFKDSQSIQSKRKIDWRSFKEKNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MRF8</accession>
    <name>A0AAJ8MRF8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal RNA-processing protein 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_105102</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC71149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059160.1">
        <property type="nucleotide sequence ID" value="XM_070203059.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30171012"/>
    <dbReference type="KEGG" id="kpin:30171012"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012978">
        <property type="entry name" value="HEAT_RRP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057860">
        <property type="entry name" value="HEAT_RRP12_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052087">
        <property type="entry name" value="RRP12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287:SF1">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25772">
        <property type="entry name" value="HEAT_RRP12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08161">
        <property type="entry name" value="RRP12_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRP12 N-terminal HEAT" evidence="6">
        <location>
            <begin position="32"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="RRP12 HEAT" evidence="5">
        <location>
            <begin position="380"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1059"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1059"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1100"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1121"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1135"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1219"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1262"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1291"/>
            <end position="1306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC71149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1342" mass="147532" checksum="635ECAD84E081701" modified="2024-07-24" version="1">MASSTESPSLATALANVRRLTSSTLPHQAKPAQLLVAIESTISSTLGTSELPHSSTAYFASLQQVLEKAVNDEVPSTSQNDEEMAETENMGQGALIPAILYLLAIIIPETPSSVILSKINIILENILPLYDTSLEHPPALRSLLQITTSLLLVPSSAQLNSSPLMKKAWNYLLELNLDPRPKVRHVAQEGIRKILTTPIPPKLQAGNHPYLPRAREWVITILQEEVKTGGLSANNKGGKKARFADGEDSEGKRAIWVIQGLRGWVAVWGDEQLSPLCGLLLSLPPLPHLTIQIYSLLAHLLSPPPADAASPTPSVLTNLPTILDSLLSSPPAMSDTPTYLSAITSALIKMSLQDPLSLNTYLPKAFNLIFHNILLSSNTTSSVCTAAADAIGSQGILRYCITDEAILATLTYMRNGSNLPGARKKSKTPFLYRLITSLTESLNTHALKTPYLFQILVALISRLRLRVLPGQQAQIDPSGKGQTAAEELLMDLIKEVGDLRHQRGFEHKDGVDQVVGMAIEVIGVAVVLDRLPLNIEPDASGAPPYPGRAHLLPLIRSRTTNDQLSFFAIYFRPLSERLFEKKVLAEDGGRAAEAKVWETVVSQIWDCWSGFCEMPRDLKEGLTTPFLSLLTSLLYTQPLLLPSLLRGLSQLVSATQRLLNSASPPEELRKQFGADQESAKEDMEFLKTLAKDMVSVLLNVFSKLPRESRGMVGEVIGLWVGIMTEKDIIETYNTVTTHLSTNLHTVQPPSEGASPISHTMLDLLIIFVPHLPPAQSQALFTAASQGTMLEHKDATVQKKAYRLLKRLLEASKLQKGNEEQFVKKLSEAGGGVGPGAQRDRLQLLSALVESLPNDSLHIIPELLSEAVLGTKEVNERARDAGFDLLVIMGKKMASGGSVKVVVEEDEESMGQPSTVQANAEEYITMVAAGLTGTTPHMISASINALSRLLFEFKDDISSNTLSELLSTLIVFLQSKNREIVKSALGFAKVSIVSLPIEVLQPHIGQIVPALLGWVHDHKNHFKAKTIHIFERLIRRFGFDEVYRCASELPEERKVLNNIKKRKDRARKRKAGKEGDEDDEQKPRQSSGNAFDDILYNSDSDLSDDDQDDDERPNQNQKGRKGQVQNQIQNQGKKGKQNEKDNRYIRNEGDEPMDLLSRGIAGGISSQNPSTQKARRVPGQDASHFKNDKQGKMVITEEDSDSDNGGNGVGSSKVIEGNAFISQHINNSDGFKRDSKGNMKYNRNTKQSREEEKNELNMIIDQEGDKHLEKGNGKEKKLEERRKKRKAMGLGEEFKAKRAGGDIKRVGGPDPYSYVSLGQAGNRKQGKDGQKINLTNKKKGSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MS96</accession>
    <name>A0AAJ8MS96_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Ubiquitin-like protein ATG12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_105787</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate functions as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Forms a conjugate with ATG5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Preautophagosomal structure membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATG12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC71828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010139.2">
        <property type="nucleotide sequence ID" value="XM_019156337.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MS96"/>
    <dbReference type="GeneID" id="30172976"/>
    <dbReference type="KEGG" id="kpin:30172976"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01612">
        <property type="entry name" value="Ubl_ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000150">
        <property type="entry name" value="Ubiquitin-like protein ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007242">
        <property type="entry name" value="Atg12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13385">
        <property type="entry name" value="AUTOPHAGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13385:SF0">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04110">
        <property type="entry name" value="APG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5 10" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <keyword evidence="6 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC71828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="135" mass="14865" checksum="3FB9A9E5F25D0B4B" modified="2024-07-24" version="1">MSITTSIHTPDLLSPSITHSAETMLSQSQLTQPTALEALEHYKKKDPSKVVVRFKAIGSAPIMKNNVFKATAGHKFQAVILFLRQQLGMKKEDPLFTYINAAFAPAPDDTVGNLFKCFGTEGHLIVNYSNTQAWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MSN4</accession>
    <name>A0AAJ8MSN4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA replication regulator Sld3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_106416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HSB8</accession>
    <name>A0A1B9HSB8_9TREE</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 10737</strain>
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    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
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                <person name="Imamovic A."/>
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                <person name="Pearson M."/>
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                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <source>
            <dbReference type="EMBL" id="OCF46173.1"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_07890</name>
        <name evidence="3" type="ORF">I206_100075</name>
    </gene>
    <organism evidence="2">
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        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700119">
        <property type="protein sequence ID" value="OCF46219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007438.1">
        <property type="nucleotide sequence ID" value="XM_019159574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HSG3"/>
    <dbReference type="GeneID" id="30176259"/>
    <dbReference type="KEGG" id="kpin:30176259"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF46219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
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        <source>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
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                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
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                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Murphy C."/>
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                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
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            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
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            <dbReference type="EMBL" id="OCF46236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC69821.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
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                <person name="Griggs A."/>
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                <person name="Hansen M."/>
                <person name="Howarth C."/>
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                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 10737</strain>
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    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Saif S."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
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        <property type="protein sequence ID" value="OCF46381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <location>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">CBS 10737</strain>
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    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
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        <location>
            <begin position="431"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="837"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="959"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="642"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="972"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="985"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1036"/>
            <end position="1050"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF46618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC72674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1307" mass="141487" checksum="15F15E59173FC3A8" modified="2016-11-02" version="1">MSYSPPLSLLYLAPPLHPVDLRPVSAISAASGTTLPTSVFPPPSAYYHRSRSLKLLQTTRTVLPFPHNLSRHSGAAEAEVAECFQDLLASSQSNMATTPQQPPKKPGFFRRMSISSSQSSKASVHASNNNNNGLGNNNKSYGRSVSGPLAGRETIAGPSYDALPVGGATNTFKSKEKPNNPGMKYQQHVSISHLGESIATRPAVSTLNAGSFGSSTAPRPPTSLATPPRSRQPIRPALASPPTPPSRRMSSSTPYQAIEPKTLPFIPQTTSNAMKGDVFQAKGNGSGPSKTASRSDSKRPDMSVHPPTHIDPISLGLIDSPREAQHREVESLRTNGPARPIPTPLKIPGDERQVNSSGSYGSISQREKTARYSRFDDAESSKPVGLPAGAQEPVYVQPNRIDPRPMVSARRSTSSSRRTPIAKIETRVMSPGSQPVVKGPDTTSPPMSARPPIIQQNKSQTSKIEVAKTKEQLSEAGAYAKAIAATINHHEGPKSSGESAPYLPAKSPAARPLPAPPAANGVSRSTSKANVVVIASSPKSHKSITRQENLESKVEVNRFAKEAQVKPSATTSPVKALTPPIHNRRSVQPLNFDFPRSPTLPPLVDPRTSNIVKADPVTQWARESDPPRSPGSPTPLATSQLPPRQSSASNSRRAVSSPLVSPNIGSDVHMSARPQLMSPDIQASTTSEVKHRDRPRATITFLLLHNRIQAALLSHLSINSFLSLTGASDTIRKRFTGEAIGRWVLKEWGIQVDREKGRSWPNLTVWEGFLESLLHDPITYSTYPPQWHNLLQHLCLSHSLIVLHLRQLPSSAFPNPPPSPFEDDFVSSVPHLPFSASMNSFGSQRPRSRLGSAAGSDAGSLTPATKMPRQERLVEIVMPEPLSSVEQQEQPSTPFPEVQKARRRGSIGSIASAASLSFGRRRSASISTDARIEMAPVTSAAPMQSGKAALPPVSYPSAKRYGFKRHGEPTRSRQSSESSRPGSIFSVQSTPSFSGHQRASSGYNMRPSFAVDRNAPPVPGFPAGLPMPPPIGGGYRSSFASSDARSSRPSENGGVSPRSGLTFSRRDLSTPPPIRPEPVFDRPIPYTVGRAPILRVFVPLSDSVQRWPSAEGAAIAVKELEKCGAMRRMKLGDLVVNTAIRQPKTTEHVLVFVPFVRHLLIPLDYSFSPTGHLPSYVNGFEIPPSFYYPFLPTPQILYLDLAPFARQALQSIRLAYDRRDVTTASGARLSAKRYLHVAGFEIGPEDRVAPEWHGMVSLETEGTAEAKHDLEKRLIGFGGSRPLVGPWELVREKSMIGTIWLRLVKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HTT1</accession>
    <name>A0A1B9HTT1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">E3 ubiquitin ligase complex SCF subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_07538</name>
        <name evidence="7" type="ORF">I206_106571</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SKP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894016">
        <property type="protein sequence ID" value="OCF46683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007902.1">
        <property type="nucleotide sequence ID" value="XM_019159230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HTT1"/>
    <dbReference type="STRING" id="1296096.A0A1B9HTT1"/>
    <dbReference type="GeneID" id="30175907"/>
    <dbReference type="KEGG" id="kpin:30175907"/>
    <dbReference type="OrthoDB" id="2342932at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18322">
        <property type="entry name" value="BTB_POZ_SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000026">
        <property type="entry name" value="E3 ubiquitin ligase complex SCF subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016072">
        <property type="entry name" value="Skp1_comp_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01466">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028729">
        <property type="entry name" value="E3_ubiquit_lig_SCF_Skp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="5">
        <location>
            <begin position="7"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="SKP1 component dimerisation" evidence="4">
        <location>
            <begin position="117"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR028729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCF46683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC72609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="166" mass="18983" checksum="8D86E84634CF2525" modified="2016-11-02" version="1">MSEKKQSVILQTSDDEQFTVEKVVAERSAMIKSMMEDLGDQEGQAIPLPNVSSSVLTKILEYCDHHKNEPLPAPDANDADDSRRKTSEIGDWDARWIQVDQEMLFEIILAANYLDIKPLLDVGCKTVANMIKGKTPEEIRKLFNITNDFTPEEEEQIRKENEWAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HU95</accession>
    <name>A0A1B9HU95_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein CPL1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_07228</name>
        <name evidence="4" type="ORF">I206_106424</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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        </source>
    </reference>
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    <sequence length="317" mass="34001" checksum="09A407C730EA91DD" modified="2016-11-02" version="1">MLKSTTIFLTLISLASSVSAGGFGGFSRGSSFNFGCGSSIKQKATHEQKDWCSSSGSFFTDYKGSPLCCSDHTRTPPSNGITCPFGWSQHFKAGCCIPPQEVSPCDCGEGYTYDKNTHKCVKNTGKCHGGQWWHDRSVTCCDDSWQHNPPKGDCPSGIKCPSGWFWHKNDKKCRPNGPRSPEPDCDDWDEHNHCCGGHTGPSQGPGKGNNGGNKWGWKRNDIQQQQTLSFPQTDLDKMYCPGSLHACTVPTAGGGEWAYECVDFATELEACGGCVGSGGQDCTQIPHSLAVGCEIGTCAVYTCKQGFQANGTSCVAV</sequence>
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    <name>A0A1B9HUE2_9TREE</name>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">CBS 10737</strain>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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    </evidence>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF18">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="52"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCF46984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC68225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="549" mass="60205" checksum="D528A2B0020AA514" modified="2016-11-02" version="1">MEDEIHVVPMHHDIESQHDYDFDIDQKKDVKATDYVTENENRDLKRGLAQRHISMIALAGSIGTGLFLSLGSSIQTGGPLGALLGYGFIGLIVCAVQFALGEVTALLPVSGSFVRHAEFLVDPGLGFALGWNIVYGNWLSIPSEISAICVLFQYWTDLNSSVFIVIFIALTATVGLINIRWYGETEFAFAIIKILLIVGLILLGLIIDLGGISGVPRIGFRYWKTPGPFVEYIATGSLGKFLGFWSVMINAVFSFAGVESVAMAAAETINPRRSIPRAVKRVFARVTLFYVLAVLIVGMLVSSDDERLGNDSGTAATSPFVLAASSAGIKVIPSIVNAVVITSAFSSSNQALLAGTRVLYGLGLKGQAPKIVLRTNRWGTPYVCVGIYILFSFLAFMSLSESALTVFYWLIDLVGCGVLISWSAVLFNHLRLVAALRKQGIPRSKLPWSNWWTPYASGVALFMCLLILLTNGWSVFTKGGWSAAGFVTSYLDIPLVLVAYLIWKFYKKTKVVSLSEVPIEEVLHYIAENPEEPETRQNGWIRFVSWLWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HUX3</accession>
    <name>A0A1B9HUX3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_06843</name>
        <name evidence="8" type="ORF">I206_102064</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700117">
        <property type="protein sequence ID" value="OCF47069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC68141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008288.1">
        <property type="nucleotide sequence ID" value="XM_019158542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HUX3"/>
    <dbReference type="STRING" id="1296096.A0A1B9HUX3"/>
    <dbReference type="GeneID" id="30175212"/>
    <dbReference type="KEGG" id="kpin:30175212"/>
    <dbReference type="OrthoDB" id="166134at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15737">
        <property type="entry name" value="FYVE2_Vac1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.20">
        <property type="entry name" value="Rabenosyn, Rab binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021565">
        <property type="entry name" value="Rbsn_Rab-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036531">
        <property type="entry name" value="Rbsn_Rab-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23164">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23164:SF30">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11464">
        <property type="entry name" value="Rbsn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140125">
        <property type="entry name" value="Rabenosyn-5 Rab-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="492"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="160"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="249"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="28"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="70"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="274"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="423"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCF47069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC68141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="884" mass="95369" checksum="C129667296831C70" modified="2016-11-02" version="1">MSITPNLPQLTTTPPPADLNPPRRRFGSFNSSNPNKPNGNNRNNRPSSSSSNHSNSSSTALVPPPISVQRTRSTSSASSTGSGGNTLTNSPFIPQQSHGQQGGPPAFDIGLAADKAQQWLSTWAPRGEGRSREFLANTLNGVANVASQVSNNLNRDGFGSRSNSFASNSGQAPVIIPPTESQGSNTSTSNSPEDTRYGSAFGLSVSPSPSPGPGNTFTLPQAPSINHTTSTPALVTKKILQPANLARLGHSNSTTSAPTTNSTSALTVGIGKMSNSPNSSSIPGGLPRTTSSNLASTSTTNLHGPSHLNPNASSSSVPSGHRRNSSTASTSHRRTSSFGIATLSRSSSITKTNTNMKSAGMPYKVGFQPQGVRHDRTEEFMQARKATGEDREREEGRLGRRWAKLVDLHFNPTVPLPTSNVPTLTRSSSSTFSISSLTGSGNDKRRSLLSIDGALDALKPKEVWKGFKNSGPGGEEGKKRAAEQAIVKWEDDNEVKKCRICQSSFSLSNRKHHCRLCGKIVCSLPPTPPALLAVQIQLFAPANPDATTTTSQGGLPPGTRREKCSLLLVADWKTGRGEEVEEGFVGWMKMDDQTPGQEQQILKNNIDSRSSRIRKGRASTNSISSINEYEEENGNGEKRGIPLPQQPKEVQVKGCRVCRECWAVVSRKQKMQDRQRVTGFARLYSALRGLQGDIEELMPEFENQLADLTESDNPLEPSTETLQTHKALLTLLTQYEHLSKRIGNLHCDEGSSQAVVQSAVARSAAAFLAREMVKLQTLQKLQKRAANAKRKSMRIHELSLSDSLNGSLDGSGSTTPTSELEREVEDIAVILQPLLEQEAQLETYISDANAQRKYEDSKALNEALKEIKLEIERITQRTSTATIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HUY2</accession>
    <name>A0A1B9HUY2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_06842</name>
        <name evidence="4" type="ORF">I206_102065</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700117">
        <property type="protein sequence ID" value="OCF47068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC68142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008287.1">
        <property type="nucleotide sequence ID" value="XM_019158541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HUY2"/>
    <dbReference type="STRING" id="1296096.A0A1B9HUY2"/>
    <dbReference type="GeneID" id="30175211"/>
    <dbReference type="KEGG" id="kpin:30175211"/>
    <dbReference type="OrthoDB" id="2563298at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF47068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC68142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="401" mass="44671" checksum="8FC9FCDF15BCCF23" modified="2016-11-02" version="1">MPAIYSSPLSNEMKRFERRDLTDLIWLFLQTDPKRLISFSALAIAIEGLVLGIILAQTTRYLINFRRSDPFWAIVSIIFGAITLFAQFGMNLWQTYRLIGKAATELLTIVVGDIRCNMTVLVFIGILNFVAAGFFGRRAWLLSKKKIWLLIPLGLGIFSSLGLSLGVAIKGYMLPSLAMNPTAKDLEKYDSWRRTDNNLIVIWAAIALTQDVIVCALMTAMLLKEKTGLQETEHGLLKLLIKLTYETMAGPVVLNIINVIVIAKQGATFADYSRLVTWVLGPVYFSSILQSLNYRRDVQRILNIAPTLRSASNDHQSTLRRAESPVLPLTSTLSTRQTSHMRYDSLTSATATDRTPTSKKNYGGTLEHEQNIELGRRGRTGTFGSMTSESGTIILGEKIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HV65</accession>
    <name>A0A1B9HV65_9TREE</name>
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        <recommendedName>
            <fullName evidence="9">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="9">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I206_06926</name>
        <name evidence="14" type="ORF">I206_101982</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="9"/>
    <dbReference type="EMBL" id="KV700117">
        <property type="protein sequence ID" value="OCF47148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC68063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008367.1">
        <property type="nucleotide sequence ID" value="XM_019158621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HV65"/>
    <dbReference type="STRING" id="1296096.A0A1B9HV65"/>
    <dbReference type="GeneID" id="30175295"/>
    <dbReference type="KEGG" id="kpin:30175295"/>
    <dbReference type="OrthoDB" id="422663at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
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            <begin position="242"/>
            <end position="461"/>
        </location>
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        <location>
            <begin position="529"/>
            <end position="741"/>
        </location>
    </feature>
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        <location>
            <begin position="22"/>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="565"/>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="896"/>
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        </location>
    </feature>
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            <begin position="29"/>
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        </location>
    </feature>
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        </location>
    </feature>
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            <end position="592"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCF47148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WWC68063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="942" mass="102329" checksum="9B6A79862D5BA942" modified="2016-11-02" version="1">MADDGIELNFAVPPSGVAVRQVAAKKGGRWTDRVKAKRDARDSYKNLKQNSTSLPPPTPAPAASKTTSQPPLSSFVAPVDRPKPSQGPQPRSVSLSSNAEAGPSRLQPFQRSTTTSAPKARSSLPHQSARPTASSRPEAGPSRPTAASTSSAPQPKTAQFISSLFSADPLPKASAPSTPVQPLGAPSNAPLVSDTSTFEGLGMDPLLVRHLKTKMHVENPTGIQRSCLPYMLSSPLDPDQTEDTSAPLRDVLIQAQTGSGKTLSYLLPIVQTLLPLSKLSYIDRSIGTLAIILAPTRELAQQISKVVEQLISMSLSLDEEDDRQFTRWLVSGLLTGGTTRTHEKARLRKGVPILVSTPGRLLDHLQNTSSFQCAKTMFLVLDEADRLMDLGFEETIKGILKALEGRRKNEINVEKELDEEGGGSMRWGFWGRGRTNILCSATVDAKVEKLSGMALRDPILFRAEKEITESQDKDKDKGDEVKNAIEEAGAIVIPKESEDKFTPPSQLSQKYVVTPTKLRLVALVALLRSLIASATKIDTEKGTKIIVFLSSTDSVDFHWKLLGGVQMGETPDGQEDDEEEDENGIESADDESGSTSKVKKTKTKKAKKTSESEMITLTSPLFPNTTLHRLHGSLPLRTRMASLKSFATQSSQPSVLFATSVASRGLDLPLVRAVIQYDLPTEGGANEYVHRVGRTARAGKGGEAWAFIAQNEIEWVPWVENKMGNAEGSKSGVKLSQVGVEDVLRKGFGGKGWEFEGRATEVQLGFERWVLDGEQNAALARRAFSSFIRAYSTHPLEEKKFFHIKSIHLGHLAKSFALREAPGQLTNTTNSLSSSNNKTRVTSSATAPANKKRKHIEGDSDNDENEKLTGGKELTARNETERRMYEAVRKQGRMIKSGGKLGEFNGTNKRRQSNLGSSGGAGGGEFQVYGTSELERMVSGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HVE8</accession>
    <name>A0A1B9HVE8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_07025</name>
        <name evidence="5" type="ORF">I206_101884</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700117">
        <property type="protein sequence ID" value="OCF47247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008466.1">
        <property type="nucleotide sequence ID" value="XM_019158720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HVE8"/>
    <dbReference type="STRING" id="1296096.A0A1B9HVE8"/>
    <dbReference type="GeneID" id="30175394"/>
    <dbReference type="KEGG" id="kpin:30175394"/>
    <dbReference type="OrthoDB" id="2563021at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628143" evidence="3">
        <location>
            <begin position="18"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="355"/>
        </location>
    </feature>
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            <begin position="374"/>
            <end position="485"/>
        </location>
    </feature>
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            <begin position="523"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="463"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF47247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC67965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="600" mass="65031" checksum="A6490CF3FA4A82B4" modified="2016-11-02" version="1">MKSLIIFIPLFLVKVLGETSKPNTGDQIQSFLFGFTESNLILPIISSCPTPISLSTINPIINSKTSDPKAPYTMITLIHEQLLDDNHIQYERLYSASLNVGDMSKIKEIQHPWMNGTQFIACIWGSNGASGGCQDLITVVPSEQTFDAYATPNSTCRNRDVLESWVTPVNETIDVEVLGISGDVSWNAWPSACSDLQINPKNGTPPYTLLVAPAAHPPVNITTSELPINYTIRLTHGQAFMLALYDSSGNSWAFGPLHAGESEDLSCLAVATGQEMPAKETRIGLSVLAGSVAGAFVVGCLGAALIMWCFMGRGKSIRKSSSEQDLYSHPRPASYSTPTNSIIGKQLTPSSNIVTPYTDSPRLEFDFGTPATLYDPHVTGPNPQSYPRPPLVGSSRSHSGGYPANDNYSDNISMREFRDPVEPQLSPPLNIPPRGQRQTSASSLGTPSNSNNVQRHPPSPRPGSFGSANNSGNNQNDEPSSPTSLRGMMQRNVYVVHADGGNGDLHIQLPDSNSRVIELPPNYRPGPGPEPNSNESILINGQQPPLPSHRLPSPPTNHAMDGQVLGLQPIRSNNMTEDELRARAQARMREKVRHEPMTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HVS6</accession>
    <name>A0A1B9HVS6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ketoreductase (KR) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_06270</name>
        <name evidence="5" type="ORF">I206_101759</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="Yurkov A.M."/>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="3">
        <location>
            <begin position="203"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF47440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC67779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="568" mass="63893" checksum="F3A3002AAAC4BB3D" modified="2016-11-02" version="1">MTTSPPPYDPPVIHQNSSPSSPSSNYSPSSHRYNQPHHRSFTNSRPNLKRSKPSILDELLPTPSEQNKSSNSSLNLIIRRAGSVAIISIFILSITFMAFTTTTNSVDIRIEGGGRRREGLKDIFRNDNHAEILNLSDQQITFPDNQSEEYNDSSSSENDIDDDETDEEITPENLNKPKQDFDQYKMLKVLPPGTIDIDSSDKRLIFIGDIHGSYDPLLRLMDKISYNPVSDRLIHVGDLIAKGPKNNEVLEWMRDHKILGVRGNHDQAVIQWRLWMEWAGGKDWQAYIDSLSFDDENSASKELQKHGKGWPKNWKWKSEHWEIAKNLPDDLFQYILDLPLIIHLPTLHTIVVHAGLLPFDPTKSISSKIQPLIQFSNISLSSNSELSMDEESIRNSQEMSILLDIPQNTIPWNLIEMRSVFMKGKKKGKITKNGKKGIPWSEIWNKEIKRCKGHSQSNLLKKEKEQKKSFKKIEKRQKPGSPTISVQGDSSNIESDLGCSPVTIIYGHAAGRGLDIKPFSKGIDTGCVYGRDLTVLVLGDLTGLKGETVNVGEHQGLLVNESCGKGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HWP3</accession>
    <name>A0A1B9HWP3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_06603</name>
        <name evidence="3" type="ORF">I206_101426</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008916.1">
        <property type="nucleotide sequence ID" value="XM_019158303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HWP3"/>
    <dbReference type="GeneID" id="30174972"/>
    <dbReference type="KEGG" id="kpin:30174972"/>
    <dbReference type="OrthoDB" id="10622779at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF47697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC67518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="287" mass="31889" checksum="2CBDBF3608972E17" modified="2016-11-02" version="1">MPSGSTEQSRPIWHENTDLRRDLRPHNPYRYDGTNWDSKDSQKHLNFNHNACLLSYMVKWRCSPYIHAHGWKPDSQRPTVLEFLTEVGFTNVLDKPTGWAGPWPPGPTRINDYNKSVTATLANCSSTTIGSTPYDPLLAQSVASQAPLWLVTPSAPSQQPQENYNSPPNPSINQSMPPLNQAGSYGQDSYMPHQYQYSQQADYPPSGQYPHYPHYPQYSQYSQYHDPSGYSQNPSMGVPSTFSANTHDPNQGMAGLPAAPDPATSSGHWGGDYSAQTDTGYGTDFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HX70</accession>
    <name>A0A1B9HX70_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
            <ecNumber evidence="4 14">4.2.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I206_05711</name>
        <name evidence="17" type="ORF">I206_107385</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:45812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="EC" id="4.2.1.134"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Endoplasmic reticulum membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.134" evidence="4 14"/>
    <dbReference type="EMBL" id="KI894014">
        <property type="protein sequence ID" value="OCF47851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009070.1">
        <property type="nucleotide sequence ID" value="XM_019157430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HX70"/>
    <dbReference type="STRING" id="1296096.A0A1B9HX70"/>
    <dbReference type="GeneID" id="30174080"/>
    <dbReference type="KEGG" id="kpin:30174080"/>
    <dbReference type="OrthoDB" id="46988at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102158">
        <property type="term" value="F:very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007482">
        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035:SF3">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 14" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCF47851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="WWC73418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="327" mass="37693" checksum="9586015924E50F13" modified="2016-11-02" version="1">MSNKTQTPAKERVEQEKERIARKGQEVKSGLTPIKIYLLTYNAVSALLWANLLYITITFILTPRSNIQQIAGKSTFLNKLFTFNNSFLSSSTKIKPLNQIINHFKGSYEFKNLGFKTKYTQSLAILEIIHTIFGFVKSPIGTVFSQVFSRIYTVWGVVEAVPEVSHNSPLFTTMLFAWSLTETIRYTYYFLNLLNIQSKILNWLRYTTFIPLYPIGASSEAFLSFQTLPSIKPILLNLISTNSLPFKEILIKSTIGRNLLWNLAKSNNNLNKNSINQTWGPLEIFRLIMFFIWWPSLYFLYTYMFKQRRKVLGKGRGKVVGGTNKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HXB9</accession>
    <name>A0A1B9HXB9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_05765</name>
        <name evidence="9" type="ORF">I206_107438</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894014">
        <property type="protein sequence ID" value="OCF47901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009120.1">
        <property type="nucleotide sequence ID" value="XM_019157480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HXB9"/>
    <dbReference type="STRING" id="1296096.A0A1B9HXB9"/>
    <dbReference type="GeneID" id="30174134"/>
    <dbReference type="KEGG" id="kpin:30174134"/>
    <dbReference type="OrthoDB" id="28737at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.790:FF:000012">
        <property type="entry name" value="Cation-transporting ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628166" evidence="7">
        <location>
            <begin position="21"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="249"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="671"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="765"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="263"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="782"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="127"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="149"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF47901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC73468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="795" mass="89341" checksum="AD3B2E1E776BE744" modified="2016-11-02" version="1">MKISKLFLGAAALFSSFVAAQNTDGSETFKYESDITRLRSLVIHSLYSHKDVFLRELLSNANDALEKLRLVSLTDRSVLSAGEGNVTIEINLDEASNGKTGQIIIRDTGIGMTKDELTRNLGTIARSGTSEFLKKAEEGQGVDGNLIGQFGLGFYSCFLVSPTVRVSSLPPATTDNSDPVQHTFVSSSTGDSFEVFPDPRGNTLGRGTEIVLSIGEEEAEFLSADKLKTLIEKHSTFSTTFPIYIKERKTSKIPVPPPQSPVEDGDSDEFADDLENDETTPKEESFEEVSEDNWVRVNDKAPIWMRDPKEVSEEEYKAFYQAVSKDDKEVPLGWSHFKGDTGSGVSFRAIIYVPSTLPKDFWSKITSGINNVRLMVKRVFITDDLGEDFMPRWLSFLKATVDADDLPLNVSRETLQNNRFLSQLQRILIRKALDLFTKLSNDQPEIYKQIAKLYGNALRIGLLESPKDKIKIAKLLRFESTRSEYTTLEEYVENRKEGQKQIYYMAGVGEKAEDLARSPFVEKLFARGYEVLLLNLPSDEPMMASLDQFMGMTTQDVSKKGLKFGDEDEHEAEKKELDAQKIAFSPLIEWLKKDLAGQVSDVTVTNRLVTSPCTIIVDSYGWSANMQRIMSAQTDSQDDPMFNMMKNLPKVLEINPKSPLIEGLLERVLDLPQTEEDEADDDVKRTSEEEEELRETVRVLFDTSLVRSGFSVADPTTYFERVEALLRRTLGVSLSAKPKIHIRPAPPTASGPVPEDEEQKIEFDPSNMEGMLGDPSQWPDWNDMKEQMNFGHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HXS6</accession>
    <name>A0A1B9HXS6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_05946</name>
        <name evidence="3" type="ORF">I206_107613</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894014">
        <property type="protein sequence ID" value="OCF48079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009298.1">
        <property type="nucleotide sequence ID" value="XM_019157658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HXS6"/>
    <dbReference type="GeneID" id="30174315"/>
    <dbReference type="KEGG" id="kpin:30174315"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF48079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC73641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="286" mass="32009" checksum="6B93F54873EE22EE" modified="2016-11-02" version="1">MSDSDIEWSRDESIQGYEGIYHDPITGRSKYQRSNNDMPADTEGPIHASGMDGPFRGGPAGELMLQQSHTWPTGQNSRTGTQSTGRFLKGGHATDFGEFWKSNVKFGPVNRFGPFVAVDSNTGLAVGRIVDQTWEQRLGPRNSIRVDERGSTTTNDSRVTNRICDPGEWSLEYTIKLGSPCLNSRVAITHLQLDDRQIATPDKLFSLWQKSNPHYRLEEGQNMTKFIHSQQEYTRMIDCLATVSIDGTERSIEDHPVTLRMVYKPCPSSIESPKASSTGWHQTVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HXU8</accession>
    <name>A0A1B9HXU8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_05964</name>
        <name evidence="6" type="ORF">I206_107631</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894014">
        <property type="protein sequence ID" value="OCF48097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009316.1">
        <property type="nucleotide sequence ID" value="XM_019157676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HXU8"/>
    <dbReference type="STRING" id="1296096.A0A1B9HXU8"/>
    <dbReference type="GeneID" id="30174333"/>
    <dbReference type="KEGG" id="kpin:30174333"/>
    <dbReference type="OrthoDB" id="5316007at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052479">
        <property type="entry name" value="GPI-anchor_Adhesion_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35185">
        <property type="entry name" value="SERINE/THREONINE-RICH PROTEIN ADG2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35185:SF1">
        <property type="entry name" value="UPF0619 GPI-ANCHORED MEMBRANE PROTEIN C1322.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628246" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="22"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF48097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC73659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="218" mass="21659" checksum="14285807D85194B8" modified="2016-11-02" version="1">MYKLTLTVLSVLALTGAVTVESPDRDTIWQSGTSSQTISWKAVSTDPDSFVVQLVNQAGFLSDSPVTLISNQSTGSSDIINTATVTYPNGNWPEGTAFQINFVTSDKNNAAILAQSNQFNITSGGSSSSSTSSSSSTSSSSSSITSSSTTSTGTSPTTLSGTSTAVTVTSTDASSTGNIPNSSNSTTTSGTSGASPLAASGLLASLVGVIGLAAAALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HYQ8</accession>
    <name>A0A1B9HYQ8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphatidylglycerol/phosphatidylinositol transfer protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_05183</name>
        <name evidence="5" type="ORF">I206_107272</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Sun S."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
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                <person name="Imamovic A."/>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Nusbaum C."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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            <strain evidence="2">CBS 10737</strain>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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            <dbReference type="Proteomes" id="UP000094020"/>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
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    <reference evidence="14" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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    <reference evidence="13" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="13">CBS 10737</strain>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 10737</strain>
        </source>
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    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
        </source>
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            <begin position="12"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF48530.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC73181.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="72" mass="8232" checksum="1DFBF9BECE0CDA7D" modified="2016-11-02" version="1">MPPFSFRDLTMPVAAFTMAIVLTAHVYNSINHARLDAAIARDQQLTDIAERRKKRYADALRTIEEKSNVKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HZ90</accession>
    <name>A0A1B9HZ90_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endopeptidase S2P</fullName>
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    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_05371</name>
        <name evidence="9" type="ORF">I206_107085</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Agaricomycotina</taxon>
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        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Murphy C."/>
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                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
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                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
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                <person name="Young S.K."/>
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                <person name="Gargeya S."/>
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                <person name="Imamovic A."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="Gargeya S."/>
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                <person name="Chapman S.B."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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                <person name="Gargeya S."/>
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                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
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                <person name="Griggs A."/>
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                <person name="Imamovic A."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC72959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009971.1">
        <property type="nucleotide sequence ID" value="XM_019157253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HZQ3"/>
    <dbReference type="GeneID" id="30173902"/>
    <dbReference type="KEGG" id="kpin:30173902"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF39">
        <property type="entry name" value="TRANSPORTER LIZ1_SEO1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="63"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="493"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF48752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC72959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="539" mass="60385" checksum="A9BC20382C2A2B12" modified="2016-11-02" version="1">MSTVTTLYPPQRVAPPASDEVALKQKKADAGIWLAIRSFIWDTDTYLKSPEERRLLLKLDLCILPCLCLGYFCKYLDQTNLTNAYVSGLKEDLGWTGNQYTYAVALYTAGYAAMQVPSTLIVQYVRPSLWLAFCEIAWALLTFCQAAVKNTGSMYALRFLVSITESAFFPVGVYLLGSWYTPTELAKRTAIFHFTSAAGAMMSGYIQAGVYTSMSGRYGLEGWQWLYIICGIITVPCGLLVLILLPDYPEKGQKRWYLTEAEFELAQERMARVGRGSNGKLDRTTLTRILKRWHIWVIPITYTFYGLGCADGGYIAIWLKSTKKYSVQKVNIIPTILNVIQSVGVVLWGFLADYTGKRYLVIAGVTILSILPTGILAAWPGSHQLILAAFLITGLQYITAVYFAWFQEICQKDPAERAVIVSLSIGLQYGMSAWVTILIFPQTESPSFRKGFPTTLAFVLMGLILATLVHYLYQRDIKRGYYENNAIQGSPLDKSDDIIQGEQEEGQYYDQKTDQGDLPIVPSLDDNLAHKRKAELSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HZS5</accession>
    <name>A0A1B9HZS5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha 1,6-mannosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_05578</name>
        <name evidence="3" type="ORF">I206_106876</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC72912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010016.1">
        <property type="nucleotide sequence ID" value="XM_019157298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HZS5"/>
    <dbReference type="STRING" id="1296096.A0A1B9HZS5"/>
    <dbReference type="GeneID" id="30173947"/>
    <dbReference type="KEGG" id="kpin:30173947"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF1">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF48797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC72912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="522" mass="59571" checksum="CEC090C3392D8E20" modified="2016-11-02" version="1">MSLSTWIDGLRSQRYTSLPTNSNPISTESIKTYSSTRKRLFQTTLIAVIFMGIVGYSLKSVKTVTIEEEPIEEPDLPFMEAKPVTESSNGRPLDPPEFDVGSEVPPEFDVGSESPHDSVEIPSSDKEEDWKSISNWGLSEELGWISPPYNVSVLGEVAENRYRLGIESGEEGSRAYFQLLHDFALSLPEPLHNQLLSSLYYHYPPNYENIISDSYSGQTNSPSMISFKNIHQTDKEFNPENELPKIWENLNKADGWKMNFLNDQQAHDWMLSKFEGSDVNWAWDYMHRGVLKADFLRYLLPLIIGGVYSDVDTRPIRPIEEWGKNSIELLDLSKTDGEEWKLKISTNPAVIIGIDVDVHNKKGWENEWPRPLGICQWTLSSSPNHPIFLDAVRRVINSTRVVENWENWRINEIEILKSKGENEKVEELKSQHRDHAMNVMEWTGPGLFTDAVVTFLLARYNVSWHRLRSLDHPLRIGDVLILPITGFSPGGERDFGAENPDSIQANVLHNFRGSWKGDGARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HZX8</accession>
    <name>A0A1B9HZX8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor 4E</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_05601</name>
        <name evidence="4" type="ORF">I206_106853</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC72889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010039.1">
        <property type="nucleotide sequence ID" value="XM_019157321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HZX8"/>
    <dbReference type="STRING" id="1296096.A0A1B9HZX8"/>
    <dbReference type="GeneID" id="30173970"/>
    <dbReference type="KEGG" id="kpin:30173970"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF73">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 4E, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="288"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="559"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="633"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="563"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="633"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="662"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF48820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC72889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="674" mass="72080" checksum="D015B8CD7C0327BE" modified="2016-11-02" version="1">MPDTSIPLTTSTSFEDVKSTEKKGLMLPPPIPSKEVKGDGIVGGNGIPGPPPRMTRLPSLKQLSDHLHYTPSSTSTSQFPNPLNTPGQSPSSIPATPPSLRIATNSLQQQITPGGGNIQSPLIAPSPSSRLRLPVSAMMRSLSSGSNGGNSTPLETLNSPNWSSRGELNNNVDLFGNSSNQNSPISLVTPQTSILPKSELGSIPGRESAPMMSRSSSTNSYIQGYSNVPSLDQIRRRISVSHGSNKSTESILPSYEVSKISQIPDSNASASSTANATTILDSVPVNVSNKESQIESPPQSSSLTDSSSSSAESELMNGKKKKEHQLRHAWTLFFDSKTYKPDPTSLPQKEGGKALTEYEMTLLTIGKFDTVEGFARHLNNIRLPSLLNKNSNYHMFKNGIRPMWEDPANANGGKWVILFKNSSITMDLAWANLTMALVGEVLDEEDEVCGIVASNRPKIDRIQIWTRTKQDYEKLNKLGRKILEIMGLEGKDRECMSMEYQYNSNNSHPPSGLFLHIPFPINSSNKILNSISTSNKLNTINQSQIGIGLGISSSNRLNNSIKSPTSTNFSTTTTTTTMSNSNGMLEPNSNSNSNSNSNSNSNSLSQRRLSGNGITSISGSNAFTGPMGGISMGRLNSSSSSSSNLGVGGGGGISRISSPSLNLSTNPTSRALKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I0X2</accession>
    <name>A0A1B9I0X2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Large ribosomal subunit protein mL60</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_04805</name>
        <name evidence="3" type="ORF">I206_105982</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010337.1">
        <property type="nucleotide sequence ID" value="XM_019156535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I0X2"/>
    <dbReference type="STRING" id="1296096.A0A1B9I0X2"/>
    <dbReference type="GeneID" id="30173174"/>
    <dbReference type="KEGG" id="kpin:30173174"/>
    <dbReference type="OrthoDB" id="2332379at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016340">
        <property type="entry name" value="Ribosomal_mL60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28271">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L31, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28271:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09784">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002216">
        <property type="entry name" value="MRPL31_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR002216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF49118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC72023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="105" mass="12062" checksum="B5F64D5DA8F0F04D" modified="2016-11-02" version="1">MFGAFRQSSISFGGLLWKSPWRLSPTRKANQRKRLKQVDSVIAAVAESGIITKSLEKALSLPMESEMLAKDKYTTFSKHHKGYRKSQHKVPKWTRLTLRENPKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I1A7</accession>
    <name>A0A1B9I1A7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Protoporphyrinogen oxidase</fullName>
            <ecNumber evidence="4 11">1.3.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I206_05014</name>
        <name evidence="14" type="ORF">I206_106189</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>protoporphyrinogen IX + 3 O2 = protoporphyrin IX + 3 H2O2</text>
            <dbReference type="Rhea" id="RHEA:25576"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:57307"/>
            <dbReference type="EC" id="1.3.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.4" evidence="4 11"/>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010542.1">
        <property type="nucleotide sequence ID" value="XM_019156740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I1A7"/>
    <dbReference type="STRING" id="1296096.A0A1B9I1A7"/>
    <dbReference type="GeneID" id="30173383"/>
    <dbReference type="KEGG" id="kpin:30173383"/>
    <dbReference type="OrthoDB" id="438553at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004729">
        <property type="term" value="F:oxygen-dependent protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004572">
        <property type="entry name" value="Protoporphyrinogen_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00562">
        <property type="entry name" value="proto_IX_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF3">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 11" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 11" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="12">
        <location>
            <begin position="14"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCF49323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WWC72227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="551" mass="61950" checksum="2F8AC23168307E36" modified="2016-11-02" version="1">MSFPKRITILGGGLSGLTTAYKLSQLPQASNSKITLIEGSNRIGGWINSTKHHVEFINEKGELIKGDVTLESGPRSLRPRGSKGAIGMLKLIKDLDLSNDIIPIPFSHPAAKNRFLLDISNSNSKLISLPNSLFSLLFNNSNSNLLKGLISSIIKEPFKSKISNEIKDESVNSFFERRFSKNLAQNLASSMVHGIYATSSDELSVRSSFPILWEKEKKFGSVILGMLFSSNKKSNEELNEIKELGKDLNENIKNWSLYGIKGGLSNLINKMNESIKEKGIVEIKLNQMINSIKINKNKNNLIEIDILNNEKKLETDYIISSISPLNLSNLLIEEKQEENLKLSNLNSNSYTTVGVVNLVYPILSKNLHPEGFGYLIPRPPLNNTKKLNKFGILGCIFDSTAIPFKEDLKNVTKLTLMLGGPYWNSNNNNNKKDFYKPKLEIPKNEEELINNSINHLENVFPILKEKNLKPILKIGKINYNCIPTYKVGHGFRMKELHHEIKQSNWNNKLSLIGNGYGGVGLNDCIYSVQHVIDSLNKGEIVTGLERWENWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I1N6</accession>
    <name>A0A1B9I1N6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_03974</name>
        <name evidence="11" type="ORF">I206_104445</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010672.1">
        <property type="nucleotide sequence ID" value="XM_019155714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I1N6"/>
    <dbReference type="STRING" id="1296096.A0A1B9I1N6"/>
    <dbReference type="GeneID" id="30172343"/>
    <dbReference type="KEGG" id="kpin:30172343"/>
    <dbReference type="OrthoDB" id="869189at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC70494.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="113" mass="12328" checksum="CAF0619A68503038" modified="2016-11-02" version="1">MSAPAAAQTTSKFQAFLNHPAGPKTIFFWAPMAKWALVAAGIKDLSRPADKLSVSQNVALAATGFIWVRYSFVITPVNYSLAAVNFFVGSTGMAQLYRIWDFNRNKPASIVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I261</accession>
    <name>A0A1B9I261_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_04107</name>
        <name evidence="7" type="ORF">I206_104316</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="OCF49585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="1296096.A0A1B9I261"/>
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        <property type="component" value="Chromosome 5"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF30">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04702)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
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        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
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            <end position="519"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="531"/>
            <end position="552"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="OCF49585.1"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="WWC70366.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="570" mass="63798" checksum="872BCF794ED3F9CB" modified="2016-11-02" version="1">MPDINTEEYLDIPGTIRIFDEAGHVVQTDHVNLHPMPSEDPEDPLNWSKTRKWIFLSCVIWYQFVVNLQAAVLYAIYTPLIEEKGLSLDQLNAGTGYLYLFIGIAAIFTQPLALGYGKRPIYIISTFACALLNIWTVYIPNNSQWIGSRLLLGFFLSPAYTLIQVSIVDVFFVHERSLPMSIYALAIYAGGCMGPVLSGQVYDAIGWKPIIWLSTGLTVITGFILLFFLEESSYIRRSKVKAAVHVVDEVERSTESGIHNHLAQIEEGENQDEGQKNIKMDTVEAGVYDVTLNNDNRSGQKFPLNTPWHGIRFWKFAKPHPQARAIIVKTVFQCLMAFRLPAVIWSGIVLGSFQAFYNFVSALASGILAEEPYNMSSSAVGLTFLSSLIAAIPVAFFGGPLADWYGLRCAKRNHGISEAEHKLHLWIICVILTPIGLLMMGLGPYYQAHWIVFVLGCGIINFVGTFGTLLAINYIFDCFHEIHPNDPDSPSSAAQDAAPYLLTSILICMIFSFALGYAITPWCFEWGLKNFGISSAIIFTFIEASAVIMLIWGKKMRRSGENYYRKVVNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I2I3</accession>
    <name>A0A1B9I2I3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_04229</name>
        <name evidence="3" type="ORF">I206_104196</name>
    </gene>
    <organism evidence="2">
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        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
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            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019155966.1"/>
    </dbReference>
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    <dbReference type="STRING" id="1296096.A0A1B9I2I3"/>
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    <dbReference type="KEGG" id="kpin:30172598"/>
    <dbReference type="OrthoDB" id="3362246at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37487">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37487:SF2">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628274" evidence="1">
        <location>
            <begin position="20"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF49705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC70246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="237" mass="22008" checksum="454D787F118D55DB" modified="2016-11-02" version="1">MFTKTLLLTLVTLATSTLGADLTISTPASLIQCQPALLAWNGGTAPYYLAVIPGGEPSAAALEDLGEQQGNSLTWTVNIASGQSITLKVTDSTGTVNYNQAVTIQSGSSSECLTAAATSSAASASTPAAVSTATAVAAATSGAASASVSASAMSAAASSAAASSAAASSAAASKASSAAASGASAASSAKSSGTAAAASAVASASASASAKSGAMSRSMINGALVAVAAGVVGLAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I2I6</accession>
    <name>A0A1B9I2I6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_04183</name>
        <name evidence="7" type="ORF">I206_104239</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010880.1">
        <property type="nucleotide sequence ID" value="XM_019155922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I2I6"/>
    <dbReference type="GeneID" id="30172552"/>
    <dbReference type="KEGG" id="kpin:30172552"/>
    <dbReference type="OrthoDB" id="284718at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="ASTER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03669">
        <property type="entry name" value="ASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCF49661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC70289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="113" mass="12286" checksum="115845327ED38271" modified="2016-11-02" version="1">MVSAPVYDKSDPKSDKIFPYHLPFTSEWSEYKDPYGQTAMTAAGAGMFVKQPILVWGAFILSVISLVNQQPLRQSKDNTSPLLVLGMAFAGVLANIMPKMMLAPEAQVGVPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I2Y0</accession>
    <name>A0A1B9I2Y0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_04441</name>
        <name evidence="4" type="ORF">I206_103985</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC70041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011129.1">
        <property type="nucleotide sequence ID" value="XM_019156171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I2Y0"/>
    <dbReference type="STRING" id="1296096.A0A1B9I2Y0"/>
    <dbReference type="GeneID" id="30172810"/>
    <dbReference type="KEGG" id="kpin:30172810"/>
    <dbReference type="OrthoDB" id="411211at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005373">
        <property type="entry name" value="PHAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039156">
        <property type="entry name" value="PHAF1/BROMI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465:SF2">
        <property type="entry name" value="PHAGOSOME ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465">
        <property type="entry name" value="UPF0183 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03676">
        <property type="entry name" value="PHAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="327"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF49910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC70041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="409" mass="45328" checksum="0BA719BB021AF203" modified="2016-11-02" version="1">MIDVGTQNLKTTSLSPTYDVVPGESVGLFQLGDNLWHVLELLRTHKTEYPKVEVSWDEESPHKSAVTIHLPYITLYFPPSPIYQLLSLIQITVPPSSSSNLELTYETQVLSSSHIPLTRARVGRLMGPTFVSKAGNKLEFPGITFQLTPSNMGDAGFGPREDIVHKLIIEATEDEELQPRLISCVIEPNTGITLGLDEDHLLRITIGQTTAQDLILDIGSPLRKFWKEDDRLSKMWGNTNTNQQSSCFWNYLQYGLDFLVDKDGIVIKIICHSNIPGTPLFQRYAKCPWTITTSSGQLDSTTPSNVFRSHFSSSQNVEEYIEQLKLTVPSPSPTPDNEINGNSVNRKKNKKRNGSPNNAMILDRLVEGGLDGVSGLGASKLIGFNGLIIEEDEKSGGICSVLIFKDNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I3N1</accession>
    <name>A0A1B9I3N1_9TREE</name>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
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        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="291" mass="32633" checksum="23756B6C575A1CF0" modified="2016-11-02" version="1">MATEREDEDLEDIFDSSLFTLFSIPPIGFAPNSKNGYYTYKPPLIHDNINFEPVKLKIPEPPSKFYNTLQAQLIWPSSIYLADLIFKEIIKVKDKTVIELGSAAGLPGIISYLKDAQKVISTDYPIDEVLNVLKDNFQRAEFSKTKGAEEGHGKKCEWEVLGHCWGQDTSELIRSISFQSDEPPDTPQSKFDVVLAADVLWTTSSHSILLDSISALLSKSGVVHITAGLHTGRGPVERLLNSARERGFQVDYKGEVRLRGDGGWDMYDESLAVKGEEERGVVVWFTLQFME</sequence>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">CBS 10737</strain>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
        </source>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="OCF50183.1"/>
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            <dbReference type="EMBL" id="OCF50183.1"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
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    </evidence>
    <sequence length="522" mass="57698" checksum="FD83EE4B1E15D601" modified="2016-11-02" version="1">MPLSPPFRPSPNSSTSPPPIGPLPTLPFEIIRRIIFHRLSIPPSYPSPLENDYVPSWDSRSGVKGKISAQKRLDERRDVTRSARGLMTVCKAWKPLVMKYLYSSPYITTNLSSLASCVLNGDSKWSDINIHIFSIPGRYITLLDLSTISFSVHPTEIRKACLSIFPSLPNVNHLKLPSGELPFGLEEIGWSPFAKNLKCLEGVEVDLDIRDDGKDGLVELLRKLPNLEVLEVLGSTIHDHPSSSEDLGPPLNLTKLHTIKLEDVKNGNLLTALSQANLPVLERLSITSFFGQPDDLTFTFQEIHGTKIRSLTYLQGKLSPFALGSEMIVPTEHILELYPILQHLAFLIPDYEQLDTIVQLLKDSPHHSLNTLTIHKFVQIRLNDGQPLNSRSKDTNTFLKGLIADSPKGMKRINVDGFKWVKPELGKMALDTGTSGEMRKLSNLLFSKHGIELGDMDGNLIPSPQSTVTACGKERVYGPMSGGGRRRSSGGQSMIRMNISMNGTCIGVNNGIERGNEEEDGG</sequence>
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        <lineage>
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    <reference evidence="18" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="18">CBS 10737</strain>
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    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>UDP-alpha-D-glucuronate + H(+) = UDP-alpha-D-xylose + CO2</text>
            <dbReference type="Rhea" id="RHEA:23916"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57632"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="EC" id="4.1.1.35"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nucleotide-sugar biosynthesis; UDP-alpha-D-xylose biosynthesis; UDP-alpha-D-xylose from UDP-alpha-D-glucuronate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">Golgi stack membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.35" evidence="6"/>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011544.1">
        <property type="nucleotide sequence ID" value="XM_019155390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I473"/>
    <dbReference type="STRING" id="1296096.A0A1B9I473"/>
    <dbReference type="GeneID" id="30172013"/>
    <dbReference type="KEGG" id="kpin:30172013"/>
    <dbReference type="OrthoDB" id="331544at2759"/>
    <dbReference type="UniPathway" id="UPA00796">
        <property type="reaction ID" value="UER00771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048040">
        <property type="term" value="F:UDP-glucuronate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033320">
        <property type="term" value="P:UDP-D-xylose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05230">
        <property type="entry name" value="UGD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000150">
        <property type="entry name" value="UDP-glucuronic acid decarboxylase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044516">
        <property type="entry name" value="UXS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078:SF6">
        <property type="entry name" value="UDP-GLUCURONIC ACID DECARBOXYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078">
        <property type="entry name" value="UDP-GLUCURONIC ACID DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0520">NAD</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="17">
        <location>
            <begin position="91"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OCF50325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="WWC71492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="410" mass="46635" checksum="F5D4B8161AA2156F" modified="2016-11-02" version="1">MAAQQEEKITEVGANRFGFDSRVQVDTLRSLYLTPAFLKEGTKEVDIAGVGHKDYGSESTYYKETDSIQYTTVAKFPPVKNLPNTERKRILITGGAGFVGSHLVDRLMLLGHEVTVLDNFFTGSRTTVSHWVGHPNFEMVRHDVVNPFLIEVDQIYHLACPASPPHYQYNAVKTIKTSFMGTLNMLGLAKRTKARFLITSTSEVYGDPEEHPQREEYWGHVNCIGPRACYDEGKRVAETLTYGYQRQDGVDVRVARIFNTFGPRMNPYDGRVVSNFIIQALKGQDMTVYGDGNQTRSFQYVHDLIDGLILLMNGDETRPTNIGSSHEFTIMEFAEAVRDIVEQIQKDEGVANPKRVNIIHKEMPIDDPQRRRADTARAKESLNWQPRWSVRQGVEEMARYYMKQIAEGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I4V6</accession>
    <name>A0A1B9I4V6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 12">13 kDa ribonucleoprotein-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I206_03845</name>
        <name evidence="15" type="ORF">I206_105246</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 12">Common component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4/U6.U5 tri-snRNP particle, required for splicing of pre-mRNA. In association with box C/D snoRNPs, required for processing of pre-ribosomal RNA (rRNA) and site-specific 2'-O-methylation of substrate RNAs. Essential for the accumulation and stability of U4 snRNA, U6 snRNA, and box C/D snoRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 12">Component of the U3 snoRNP particle. Binds to the C'/D and B/C motifs in U3 snoRNA. Component of the 25S U4/U6.U5 tri-snRNP particle, a subcomplex of the spliceosome. Binds to the 5' stem-loop of U4 snRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
            <location evidence="1 12">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011740.1">
        <property type="nucleotide sequence ID" value="XM_019155586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I4V6"/>
    <dbReference type="STRING" id="1296096.A0A1B9I4V6"/>
    <dbReference type="GeneID" id="30172214"/>
    <dbReference type="KEGG" id="kpin:30172214"/>
    <dbReference type="OrthoDB" id="1924699at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21104">
        <property type="entry name" value="SNU13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000002">
        <property type="entry name" value="NHP2-like protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002415">
        <property type="entry name" value="H/ACA_rnp_Nhp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00883">
        <property type="entry name" value="NUCLEARHMG"/>
    </dbReference>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Imamovic A."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
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                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Abouelleil A."/>
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                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
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                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
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                <person name="Griggs A."/>
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                <person name="Imamovic A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF50882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC68657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="24914" checksum="8310DA9201C1C6A6" modified="2016-11-02" version="1">MWRSGPRQLNNSDRAGPNTRCQKCLKLGHHTYQCTNSRPYVARPSRTQQLSSGKIGREKPSIEVPEEFKSSSKIGLADKILKAKEDERMKEELKKRGGKDKKKRSSSYSSDSDSSSSISSSSDSDSSCSSSTRSDSRSPPPSKRRKRRSPSITSSDSHSDSVDSRRSASPPPRRKRYSSDEDEPRKPRKSTPSLSRSLSKSRSRSRSISRGRSLSRSKSVDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I5Z6</accession>
    <name>A0A1B9I5Z6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_03012</name>
        <name evidence="3" type="ORF">I206_102659</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF50950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012169.1">
        <property type="nucleotide sequence ID" value="XM_019154766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I5Z6"/>
    <dbReference type="STRING" id="1296096.A0A1B9I5Z6"/>
    <dbReference type="GeneID" id="30171381"/>
    <dbReference type="KEGG" id="kpin:30171381"/>
    <dbReference type="OrthoDB" id="2565088at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628413" evidence="1">
        <location>
            <begin position="20"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF50950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC68725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="482" mass="46532" checksum="BD053E77CBA4080C" modified="2016-11-02" version="1">MYATRTLALFAILPYLASAAPIFGFPNVGDILGLGKGNSIDASTVAIVVPKITSIVGSAIPAATSAIGVIVSSETKFIGSAVAQATQAASAITNNANIGGSVDVNAGASGSISGVALPAVNPASLINSVTSAAGSIVNSSGGLTGVASGTLGQVGSTANGVISQVQDTAKGAAGSTVSTASTVVGGTVGKVEDTAKAVAGSAIGTTSNIIGGTVSQGQNAVSGVLTGATSQVQNTAGNVVNQVFGSAQNVVGGIVSGTTGQASNTINGVISGITGNLGSGLLSGAIGQGSNVVGGIVSGVTGQGSNVVGGVVGQASGVLGSIAPASTTGVVGGLNSSPVQIIQSLSNVITNLQPVSLTDTISHLQDISAVISAMASTEASLMTDTASAQFSPFINYASQFVRNLNTFYKSLPTAITSSTQFLTVAAQIDQATAAMLNGIKITTAGSTQLATALYGDGQFTVSNMVAFLPKTLAILPPAPISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I6Z6</accession>
    <name>A0A1B9I6Z6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Allantoate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_03336</name>
        <name evidence="9" type="ORF">I206_102983</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF51269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC69047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012488.1">
        <property type="nucleotide sequence ID" value="XM_019155085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I6Z6"/>
    <dbReference type="GeneID" id="30171705"/>
    <dbReference type="KEGG" id="kpin:30171705"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF59">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF51269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC69047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="61427" checksum="8982EAB68F6A6248" modified="2016-11-02" version="1">MSQQTPNNIHQDDKDLEINHVEAIDHSQGGIGAVDAKYISHAQDDAANLLREVGPVEYTIEDDRRVLRKLDIWVCLPMFIVYTLVHLDKNALSYAAVFNLKAEAHLVGKQYSWLGSIVYLVQLVVQPLSAYALVRFPMSWWVVGNVFCWGICVCCMAATHNFGGLLATRALMGGFEATISPSFIAMTQMFWRRREQTYRNTAWLMSSSVAGFIGPILSYGIAHVKSGIKPWQGIFLFLGCITLAFCPLIFWMMPNDIPSAKFLTPQEKVIAVERLRDNNTGTRTSSWKWDQVKEAVLDPKTWIWGLMLSCMAIPSSGIGTFGTLITKGFGFNSFDTILFQMPPYVLTITFLLVGTWVMNKINLRFPIVAFFTLFPIAGAAALLYVPRNKPHALLGAYYVIMLYTPLQPLVYSWANMNAAGTTKQRTVGAILFIMQCAGNVAGPQVYLDDEAPVYKTGLYTDMACWSLLFVLICTMALYLKYLNRRQAKKRERMGRMSNIRDMSIMTLEQAAAYRRELAAAGEGDDVNAHAYDDLTDFQNPDFHYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I877</accession>
    <name>A0A1B9I877_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_02356</name>
        <name evidence="10" type="ORF">I206_104817</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPL family. K-HECT subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012860.1">
        <property type="nucleotide sequence ID" value="XM_019154120.1"/>
    </dbReference>
    <dbReference type="STRING" id="1296096.A0A1B9I877"/>
    <dbReference type="GeneID" id="30170725"/>
    <dbReference type="KEGG" id="kpin:30170725"/>
    <dbReference type="OrthoDB" id="423283at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045322">
        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057948">
        <property type="entry name" value="TPR_TRIP12_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25579">
        <property type="entry name" value="TPR_TRIP12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="8">
        <location>
            <begin position="1719"/>
            <end position="2069"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="759"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="962"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1267"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1427"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="303"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="780"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="805"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1267"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1287"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1299"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1336"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1445"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="2036"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCF51641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC70865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="2069" mass="223409" checksum="964E51BF241BDBB0" modified="2016-11-02" version="1">MNDKENNNVSQSEQYLGPTFHTQQNITTISNPDNNQNIGESSNLQSTEDSIITPCTTRKKPKKQDEQLKSDSEPVLTRRSARLSISSKTAPELPVSGPSSGGKGKKRVHIDETPQEGASSKKKPRSSFSALPVPSTSIDSSNTPTQIDRKGKNRAVQSLSPSTLALPSAENRFAPTKPLTQSANTPTASGRYDLRHKSEEVQTATLGDSDKGKGKANVSSRGKGKKAAYKMPKKANTKQKRPTIGSSSDRTKKGDNSARRLDDDTLDDDDTHWVDEPSYSRRTGGLLDDDDNEDENMDRSDHDDEDEDEDEDDEEANEGGETNPSGRPAGNSYDRLARLANDTGLHLDEATAAAIFGGGFRAFGGMMSGLSNRFKQLRTNLKSRRITTRIAALRECSELLLVSTENTLGASFSPSSFATEFIAILNGKPNIDENQDSGDENQGLDEMDEDAQLAAALAMSSGGMMPALGGSEDEMECQLLACRCLAHLMEALPGSGHTLVNLGAVPVLCSKLAEITYIELAEQTLSTLEKISAEYPAAIVREGGLGALLNYLPFFSTNVQRTAVTAAANCCRNISSDHYAQIKEVFPIIRDTLSLGDQRLVEQATLAVVRTIESYRHNAQHLEGLLDVPTVTAINALLMPSGGSPLVSPSTYTHLLKALTTSARGSAKVSLAFLDAGMTSTIYQILTGVLPPEHDEDEQGGSSGGQGLAGGVADMAVLQNLAHRPKDQVEEALGLICELLPPVPRDGVFDPKLYTEKSLSRVKKGRKADRPSAPRRSSRVADATTSGASTAPPTPSGTDVPLPGEASTPTPASTSAAREAALLKAMKDANAQMDQRLELLKSNPEIIGKFIKAVVPVLVDVYAASVVFRIRTKVLTGLVKAVAFANPDQLKNTLRSVPMASFLCAIVSSKDNPIFVQHALQLVELLATKIPEVYQASFLREGVVFEIDALAEQEMAKEKTAREAALVKTEPEEAEEPSADASTSTPSAIPPIPDDLKPLLTLAGFAGGISLLGEPASGPSTPKRSSSSYLEPSDANIVRARMLQAKKVFESGGEHHQAASLVLDEIKRMVQKLCRHEANEAELRDILRDIALRFSNVDQALSSFELLKSGLVDGILEFVDIDGEVTSATRRTMLFEIFSDTTLSTPSPLTMLVKRLHESLGRLENFDVEIAFGGGNDAPRPSTSTLSRTMRVRLQAEEGEDIPKQVQTLSVTIQAIASMQALNDYLRPRVADGNYGSSLSKFFAAYAVGMSEPGGAGGNPTSRFLSALAGAPGPGEGSSSSRAPLLGTSNPAASGSAENKAKSADVKDTTDKAEEEKENKGESSSSKPQRRRSARLSAQGTGETSASAVPLGEPSTPAATAAVTNSEPSILPSMPLDMDFDDFSDEEDDYDHEVFEDEMEEELTRPTESVVNMNVVADGTRVEAKTPEGTRIATPQQNPPAVAASGSNADTGGASTPRGSSYAGAVKTAPSDWHLEFNINGNKLSLDDTLYGAVHRNQNAISGGNSAAYGGIYNLPVTIKFRKVAGPAKNDGAAEAPSPATVTSTFPIGLEPSTPTSKILRLLRVVHNLSVEGRDAIGHGLNDGGILDEKLFVNNKLTAKLTRQLEETMIIASDCLPDWAIELPKHFSFLFPFDTRYNFLQSTSFGYGRLITRSQQAAHSNNRNGRRDDVSHLARLVRQKVRISRSQLLESCAKVLEIYGTSQGILEIEYFDEIGTGLGPTLEFYSLASKEFARKNLGIWRDEDESKESDYVFHPKGLYPAPLDEKQSGFESKLSWFKTLGLFAGRALLDTRIIDVNLNRVFLKAILGQPIKKNIPTLKAIDAHLARSLERLQTYLFARKEIEALKLPASSRRTKLAALTVGGARLADLSLDFTLPGYSIELVPGGSLIDVDDSNLEDYLDKVLEMTLGSGVERQVKAFQEGFSSVFSVRDMRIFSPDELGLLFGNADEDWSRETLEQSLKADHGYNLDSRAVQNLLEVMVGYDREQRRQFLQFITGAPKLPIGGFKGLTPQFTVVRKPHEPPFKADDYLPSVMTCAQYLKMPDYSTKEILAAQIERAMKDGGGSFHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I8J6</accession>
    <name>A0A1B9I8J6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_02593</name>
        <name evidence="2" type="ORF">I206_105053</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">CBS 10737</strain>
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    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="5">CBS 10737</strain>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
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        <property type="protein sequence ID" value="OCF52534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1296096.A0A1B9IAU4"/>
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        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
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        <property type="entry name" value="Pept_M20_carboxypep"/>
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        <property type="entry name" value="Pept_M20A"/>
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        <property type="entry name" value="Peptidase_M20"/>
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    <dbReference type="PANTHER" id="PTHR45962">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962:SF1">
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zn-dependent exopeptidases"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="30"/>
            <end position="48"/>
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    </feature>
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            <end position="458"/>
        </location>
    </feature>
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    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="220"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
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    <feature type="binding site" evidence="7">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="284"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="557"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF52534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC69233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="589" mass="65209" checksum="F6F759764482C66A" modified="2016-11-02" version="1">MSEKSTSTSLPLPSIGSYKIHKKSSNKPKIFLGILFILATLVNFGPSLKSINPLNKNDNDLISFEETENWLNKFDFEDLQDWSKCPKQPKPLFPNSTWNLTEEEKKKLVATYSKAVQIPTQSFDDNGEPNEDPRWEPFFDFQNWLKDTFPLAHETAKIEYINTLGILATFEGSDPSLKPLLLMAHYDVVPAPKDTYDRWTHPPFSGYNDGTYIWGRGAGDDKPLLVAQWESITNLLENGFKPRRTIILSHGNDEEEVFARRGQGHIAPFLEKRYGKDGLLMVIDEGSGTVDDFYGAPFAIPGMGEKGYMDIIISVGTAGGHSSVPPKHSGIGITSEVVLALENNPFPTKLTPASPFLTSLQCAFAHSPDLPKKYSKLLSSEGPNSYPELANIISQESLSRKALVGTTTAVDVINGGSKVNSLPEQVNTLVNFRIDFTESINSTKNHINKLANKIAKENNLNYFGFENKEKEELGGKYLSIDIMGLSLEPAPRTPAHGGVWDLFAGTVKAVIPGPNGEERIVTPFASTGNTDCKMYYNLTKNIYRFMGSSASSGFAAHTVDEKFAIEGYFQIIKWVHAIIQNADAYSGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IAX5</accession>
    <name>A0A1B9IAX5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_01874</name>
        <name evidence="3" type="ORF">I206_103122</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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            <begin position="21"/>
            <end position="39"/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF52581.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC69186.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
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    <sequence length="276" mass="31172" checksum="58075BD3579B779F" modified="2016-11-02" version="1">MTQQEQQMTNQSCPLEHSDSSEEPESSDCDDTDCSDDELNGFSWPRTYIDYILESDGSARGSTVQEESNDSAALPEEIDSTQTIDIAGARKSREDSSNTQELKRCIQEYVDTHLRSARDTFRSYIQEAMPDIFLPMEDDVRGVVSNPKHGKILKGKASECNNLTDSIPEVEREKFRAWKLWENAEWPGPKPPLNIGTAFYMTVLLEDFQCDTDSETIDTSEISIAQALDSLRDKVKSVRTAKNRPIRDLEEAFSLAERSWALEGAEKLFHGFGPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IB03</accession>
    <name>A0A1B9IB03_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide alpha-N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_00139</name>
        <name evidence="7" type="ORF">I206_101185</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
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        <text evidence="3">Belongs to the acetyltransferase family. MAK3 subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="OCF52842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC67277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="268" mass="30780" checksum="9CB3AD55B4C8D198" modified="2016-11-02" version="1">MISTIHAPEILTNSSQKSINDIKGKGKAKVKETESITIIDDKGDELFYRNYKDEQTDLEYMMKLVEQELSEPYNVYTFRYFLIDWPHLAFLVFPSSISKEPIATIICKQDSHRGKTNRGYIAMLSVDRAWRRRGIASKLIKVAIDEMIRRGVHEVVLETEFDNAPSLALYDRLGFLREKRLHRFYSNGKDAFRLILPLETDPPPPFETDEEAEQGRWSVGAGSEPGPGMELGVINEEGPLRYFEETDVNMGDTPKLPPRPLDDWGMYT</sequence>
</entry>
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    </protein>
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    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="OCF52630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Chromosome 4"/>
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        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008733">
        <property type="entry name" value="PEX11"/>
    </dbReference>
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        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652:SF19">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05648">
        <property type="entry name" value="PEX11"/>
        <property type="match status" value="1"/>
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    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="1" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC69137.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
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    </evidence>
    <sequence length="394" mass="45064" checksum="66E89D4B75FA8B9D" modified="2016-11-02" version="1">MSDPIASRKSTSINPENRESIHHSHSHSHSHSHSSIWKNTPNSTLHPYPSPPESNSFQTDLQPWANHQKYSSISSDSYSNPRGKNSNIMNNLQPISLEQSWRSDLSPNKRNGKEREIIWDSTNNLPINNELDALGLSINNNSFQSNSIISTNRKYENYLESKGGNKKDPMTVDVLARIIDTSNGRDKILKCIQYTLRTYLYLLSLINKIRPLSPWFKSNSKRMKIAISGLSLTRKCLLLFNPLHPLSDLLSSEPMSARTLIKHLIDLFSALSDDITCFSKLGFINKKIGNKSDNWSNRFWLLTTIMGLYKLHLNTIPKIINSSNNLEKRKIELNDIKWTNRKLLSDLIFVGYDVLELNFEIIEEPMKCLTGLFAAFISTFKLYNKHWEASIGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IBC3</accession>
    <name>A0A1B9IBC3_9TREE</name>
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        <name evidence="3" type="ORF">I206_101274</name>
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    <organism evidence="2">
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        </lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
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                <person name="Litvintseva A."/>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="Sun S."/>
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                <person name="Heitman J."/>
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                <person name="Young S.K."/>
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                <person name="Gargeya S."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="Dromer F."/>
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                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="David-Palma M."/>
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                <person name="Bowers K."/>
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                <person name="Mohammad A.W."/>
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                <person name="Yurkov A.M."/>
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                <person name="Heitman J."/>
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    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
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                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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        <location>
            <begin position="186"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF52953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC67165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="628" mass="73044" checksum="041DCF117A39A77A" modified="2016-11-02" version="1">MAQQPKRPFWVVESMGSSEIQGNSESNFTSQLKSDVQDDSVKGYKRRRIENDAFNNVTPVMKSSLPPRPQSVPLNSNPSTNTPHRMITRSSTKSTIPLSNERAQIASPSETIIPNSLQRVAPTSSNLNSSSLNTSSIVNSTNDYGKVFSYPGYPPFTPIRTTSSHQFTNYQTNHKNDDSIESIGIIAILRNQLENSNLTIRKLESRIINTESILFSKSTELDNIRMENQSLKFQLNQISNQNIPKQIVFDDQVQLDNQKKEYENKLNLFKQQLDKIVENVRIDKENIQKESKETNERLKIDLTEKDKKIKEAEIIIKELKGKGDIDIKSREVLKRLSEARQKVIENLQNDLKAEKNRGEEIRRVGWEQLNSLRKEQEVFQERFKVLENENSSLRKTNDNMRTTERIRHDELLRERRELEKERTNLVKDEKTKSAERTKIEQLEKDLSMIKSSHQRTLDEKDGLAREVKQNSRKCQELNEQYNLISESADFHRNENEQLRGCLDVERKFNGGLNAEIKELKRQNTNLDNQVKQLKDYYSKLKTRSASSQDQSTLINEKNPIDDLLEKDRLKLWSKIARLKNHLRNIEEKLSKEGKCLSQLPEKRVLEIKSLTENIAKSEDKLRESLRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IC06</accession>
    <name>A0A1B9IC06_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Retrograde transport protein Dsl1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_00272</name>
        <name evidence="5" type="ORF">I206_101054</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF52971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014190.1">
        <property type="nucleotide sequence ID" value="XM_019152052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IC06"/>
    <dbReference type="STRING" id="1296096.A0A1B9IC06"/>
    <dbReference type="GeneID" id="30168641"/>
    <dbReference type="KEGG" id="kpin:30168641"/>
    <dbReference type="OrthoDB" id="534815at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990423">
        <property type="term" value="C:RZZ complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046362">
        <property type="entry name" value="Zw10/DSL1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055148">
        <property type="entry name" value="ZW10_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048344">
        <property type="entry name" value="Zw10_middle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12205">
        <property type="entry name" value="CENTROMERE/KINETOCHORE PROTEIN ZW10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12205:SF0">
        <property type="entry name" value="CENTROMERE_KINETOCHORE PROTEIN ZW10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22766">
        <property type="entry name" value="ZW10_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20665">
        <property type="entry name" value="Zw10_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centromere/kinetochore protein zw10 middle" evidence="2">
        <location>
            <begin position="215"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="ZW10 C-terminal helical" evidence="3">
        <location>
            <begin position="849"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="629"/>
        </location>
    </feature>
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        <location>
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            <end position="505"/>
        </location>
    </feature>
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        <location>
            <begin position="506"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF52971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC67147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IC77</accession>
    <name>A0A1B9IC77_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_00328</name>
        <name evidence="4" type="ORF">I206_100998</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014246.1">
        <property type="nucleotide sequence ID" value="XM_019152108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IC77"/>
    <dbReference type="GeneID" id="30168697"/>
    <dbReference type="KEGG" id="kpin:30168697"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="beta-trefoil_Ricin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628509" description="Ricin B lectin domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="2">
        <location>
            <begin position="26"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF53027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC67091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="191" mass="20526" checksum="43FB451390608165" modified="2016-11-02" version="1">MLAQILLTPLLATLALASPVPRDSYSGKRIRSLASPDLCLTVQNGYAAYGTIVAFTACSQDSNGEGYLDQFQYWSVVGPQRGQIKLSSNDEMCLDGGDESNGSEITIQACEDEKDSQIWTVGTTGTGNQPNLQLAVGSSESQCLDVVKDSNPVQTKPYGSEKDSQVWSCHTQDGNEADAIQQFFELATADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9ICA5</accession>
    <name>A0A1B9ICA5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tim44-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_00550</name>
        <name evidence="6" type="ORF">I206_100777</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC66870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014468.1">
        <property type="nucleotide sequence ID" value="XM_019152330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9ICA5"/>
    <dbReference type="GeneID" id="30168919"/>
    <dbReference type="KEGG" id="kpin:30168919"/>
    <dbReference type="OrthoDB" id="19619at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mba1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051975">
        <property type="entry name" value="mtLSU_mL45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28554">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L45, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28554:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07961">
        <property type="entry name" value="MBA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF53249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC66870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="34805" checksum="73E491E0344AECEF" modified="2016-11-02" version="1">MSFLPSLRASAPSSSSIISISKPLLSSNPSRPYVQIRSIASTSYRHAAVSSISRSVQDVERELEEQKQMLAKAHRTNPGMDTGFQNLPVFESYVDPQKPFYYFLKGVGDKKYKAERAERASLTRQSLAEIIKRGALPPYQNDMRRSGIDQWRQLMLFTRRQQYIKKSITFFNKMYLDYMKIQAEGTIGQATGIAKDTALQTALNVIRGRKEKMSWELIKENKKPYLVSSRMTVVDPRDMKMAAQVTIRFDTQQALTIQKGTQNPVRREQRVIENIIFEVIPVDITCDWKVKGKLVEQQEVKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9ICN7</accession>
    <name>A0A1B9ICN7_9TREE</name>
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        <recommendedName>
            <fullName evidence="7">Carboxypeptidase</fullName>
            <ecNumber evidence="7">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_00721</name>
        <name evidence="9" type="ORF">I206_100604</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="7"/>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014637.1">
        <property type="nucleotide sequence ID" value="XM_019152499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9ICN7"/>
    <dbReference type="STRING" id="1296096.A0A1B9ICN7"/>
    <dbReference type="GeneID" id="30169090"/>
    <dbReference type="KEGG" id="kpin:30169090"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000226">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF113">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
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            <authorList>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
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                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Sykes S."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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    <reference evidence="2" key="3">
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
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    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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            <end position="71"/>
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    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF53556.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC66565.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1B9IE19_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
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    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
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                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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            <strain evidence="8">CBS 10737</strain>
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            <authorList>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
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                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="Gargeya S."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
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                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF53750.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC66367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="497" mass="55353" checksum="3479427367EA6967" modified="2016-11-02" version="1">MSARELHSTKDDEKVIDQIDIKDVEYDDQDPTHLALEETEIDQAYLNASKSTRFYRGTLFQMFMFGALSFVGPAMSDAITNLGGGGLSTPYLANLATSLQYAMSCLMTLFGGPLINKFGIKWSCMIAAVTFPLSGSGYYVSAKHKVDWYLLFSRILGGFTSGFLYVGETTAMLSYPHLHERGKYLGIWSAMRNSGSVVGGAINFSNNSKASSSGGIAWSTYLIFIGFECTGVIWAFLLSATKKVRRSDGSKVPYSRDISWKAEFVALWKHAQNKRTWLVFMPAFYSFFYGGVYGTYLSLHFSVRARALSSLIIPTAVIPMVMAYGSMLDNKKWSQKKKGWVAFGMWAIPQAACLIWTGIEYSKFAKEGKIAYDYSIHGKRWAEAYLPYFIIFTTGYWTQLSIYWILGTFSSDVKSSSRTGGLFRAFETAGQAVSYGINANTGDKKIPLYVLCVVFALTVPCMTALIRLIPERPAEHDDIADMDKAIIAREQMEQATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8KXZ4</accession>
    <name>A0AAJ8KXZ4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_100425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC66522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
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    <sequence length="209" mass="22434" checksum="0361CCF9AF374535" modified="2024-07-24" version="1">MVRATSILRNAANAGKPKPMSADHTLYHAMPTGFWKKFLNPEISSGLPIPTENRYPQPGSRTERYATPSTAASDVAFNPYYKRDVRRAYPQTSFITQTELTSLLLASPTLESLPSPETATEVRGDSSAISPSSDSADQTKSIVTSSVPSLSSVLEKLPQGKAFTGSGIKTASGTGNGLPPSPPGAKWKPQRGDEIPHGEYAYFPMIGYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ8KYW5_9TREE</name>
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    <reference evidence="3" key="1">
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
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                <person name="Dewar J."/>
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                <person name="Griggs A."/>
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                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
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                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="AlphaFoldDB" id="A0AAJ8KYW5"/>
    <dbReference type="GeneID" id="30169552"/>
    <dbReference type="KEGG" id="kpin:30169552"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
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        <property type="entry name" value="OxRdtase_put_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43249:SF1">
        <property type="entry name" value="D-GLUCOSIDE 3-DEHYDROGENASE"/>
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    <dbReference type="PANTHER" id="PTHR43249">
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    </dbReference>
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        </location>
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        </location>
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        </source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC66243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="406" mass="45087" checksum="4147770303AAB1D0" modified="2024-07-24" version="1">MSTSTNEFHVIMVGAGFAMFGTPEGPWNIAKRAEAKLGERLKVDAVIEVDPKRAEAALKIKSEGPHKSSYENTVILPSVAEFKKLVDQGKAPEPRAIFVATPPTVRGSTLPGKDLEIQLNRAFPNVAIFFEKPVATGKPWEESVGEALKVSEYLKANHKAPISIGYVLRYLKIVQQVKKIIEENNLTVMATNARFVVAYELAVKTDWWNKDIQLGPVIEQATHICDLVRFLGGEIDFNTISAHALEAHEKPGQLSKKNFDESVIPDHLRIPRATSASWKYESGAVGIFLHSTALHGTDYEVQLEVYADGYSFVLQNIFGTSKAPELLVRRPGSDEFEKTVTPGDDAYQTEMNHFIDAIEGGAEPEIFSSYEDAAKTYEMTWVIRNSAENANSKIKEQKGGKSYKLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8KZ97</accession>
    <name>A0AAJ8KZ97_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_100181</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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    <reference evidence="4" key="1">
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019015057.2">
        <property type="nucleotide sequence ID" value="XM_019152919.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8KZ97"/>
    <dbReference type="GeneID" id="30169514"/>
    <dbReference type="KEGG" id="kpin:30169514"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042561477" evidence="3">
        <location>
            <begin position="24"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="497"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="534"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="573"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC66280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="639" mass="71605" checksum="A70CDD59E07A98E3" modified="2024-07-24" version="1">MVQTSTANLACLIASMFLGSVSALSSFEYMQVTKNFADAFMPSTSSDLVANLNTKKALFAEDVQGTVDIAGNIDGRDYSTDFLFGLFLGAAQNSNVPSPIGIPQSYNVTSAVVEHNTVSAGIKFELEYAILNTTYPMELEAFLTINDKKQITQYDLIFRRWAWATDTIIPQLTPYMAQLLGMSNDNSTLTLHQFLAYSSCTQTMGYCIGTNSQYDSLMECVANTTSLPTGQFYRVGENNLACRAVHASMLQLNPKTYCPAMSVSGGDICVDRNYAETVRGDHFSQGFLAPKYITQENKKIVQNVWASSDDKELSPLLEISMSTQDMHSWDATFYATMTFVYFIFYYIFAKATDFLFFRFNRAYKDLSREHQKNVTMYFMTIVFTAIALGLQLVGSPGFSGEWHYWELRCVRLAGVLTVALYLFELIFRFNMRLPLVAHHILTIFAISLGVTTMEYTQNPGFMLSGIIWLFQATTEQPTFVGLMGYRLKWKKENVALILKISAIQTFIFKAASAVALLVYWALHQRFHYNSIDYVWSVFVWVIAIGLFLTQIWGSYVTYIIGVAVLKKKRPGPPIRLESDSSNTSSTDIEKGRDSDLDLRSGTITPAETDVLGYDGKRVKAESYSMSQYNSSSGLIATGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8KZQ7</accession>
    <name>A0AAJ8KZQ7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_101330</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058472.1">
        <property type="nucleotide sequence ID" value="XM_070202371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8KZQ7"/>
    <dbReference type="GeneID" id="30175071"/>
    <dbReference type="KEGG" id="kpin:30175071"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="255"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC67422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="680" mass="75737" checksum="EF99FFB43DD84754" modified="2024-07-24" version="1">MCGPCTRDNVECRWDIGPKRHFPPDTAGKKAGTKRMKRRHSDASAGISENRTNGRDAIGSGVNWLKLVDTEGSVRHYGPMSTFAHLPENSPNSVLSNTSCSPENLSTLPWICQNGQMNAYQMSTSVSGARPSSLMYGHLPTNVNLTWEEHEELLNLFEAFFGSFCMVVDISLFREDLTRTHGQHTTNYFSPLLHNAILGLAVHFSNKVHSPSDAAFSAKAASYILQECEKPMMSTIKGLVILGSLQTLLSREDLSSLYLSMALSLAKSFGLHIDCAQLVQSGQMSADQAKMRRDQFWSLYALEKLWCIALGRTSTFLDYNVPTYTVDPIIDEKPWLEPHRFQLDRPQSHMTSASKASSTFYWFCKLLMVASDINSNLCSLKVDKRPIGGTQVQSLRHRLKVWKDQLPPEMQLNIEDERCPPPMLMIMHMYFWLLVILLNQPQAHGRLARKSGDADAIAASEQAASEALELLLVYEWKIGLRYGPLTTTHIAYAAASVMLMSSVTLATPTARKEAMLQKFDQCVELLTKMQHVWAAQTAGILNKLKDEWIPSSAPTTRSSSAKLAVTEPNRIHAPDADTVQIDMEDIFSSETLHSFNPSEGQASTLFRPDISDAIETSASLQSGQTELPSAALVGSLWPMFHSSGVPYMSFPDGTEDYWSQWMSLFPETGDVTSCEFIPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L077</accession>
    <name>A0AAJ8L077_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_100696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014547.2">
        <property type="nucleotide sequence ID" value="XM_019152409.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L077"/>
    <dbReference type="GeneID" id="30168999"/>
    <dbReference type="KEGG" id="kpin:30168999"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WWC66790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="374" mass="41158" checksum="6CD7E3D99C0B9AA0" modified="2024-07-24" version="1">MAPKLKSSQSPGTKRKLKRGFGSSFNDALVKNVKADLTTLDEQAATRYAFIAKWFEKCASDLGGVSVNGKKCMTWTEAMSDEVGLWKLQTYKTVIGYYALKAKPSDKTLKRIDVQTLLSFTYRIHAAHNFWHNLSGDPQLREKLKHFIDECEVTFKLRRSKFIRAALTPASVYALVQQSARLSLPIRSILSIVLFQAICSSTGYRAGSLTRAASKRLMSAEKSGLKYSSITAWAVPGSTGSKNTLIVWISPRSFKATHAKGSSAVLMDNGKIGVSANYLIMMAAELDGVLGDLTVEKILDPAFLGNSSKPRRVVFDENKVDQHILVRRAGGLSLCTSDFVAAAVYQKHDYETAGQIMQHRHGSNVTGRYFGAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L1M9</accession>
    <name>A0AAJ8L1M9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Enoyl-CoA hydratase/isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_102339</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058648.1">
        <property type="nucleotide sequence ID" value="XM_070202547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L1M9"/>
    <dbReference type="GeneID" id="30171055"/>
    <dbReference type="KEGG" id="kpin:30171055"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF75">
        <property type="entry name" value="ENOYL-COA HYDRATASE_ISOMERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC68412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="30169" checksum="B5460047ECC1359D" modified="2024-07-24" version="1">MTSKYLKVSHPASNVWQITLTSPPDNRLTPELLSEFSQALDQVELEWRKVGGGKFNPKEREKYEGKGAGALIITSDNEKFFSNGLDWERSLKIKNFFEEIFDPLTWRLLTFPLLTIAAINGHAFAGGMILALSCDYRIITSGKGFLCMNELQFGSPLPNSFNALLSKRIPNPQHHRNTLLARRWTQKELSQIGLVDEVVDSDKVISRAVEVGKRDGGKVAAGAWGAIKRGAYHQVLDYSQSYRKLNLPPQEEQEFFDRVGKSQSKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L1T5</accession>
    <name>A0AAJ8L1T5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Argonaute</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_101867</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058566.1">
        <property type="nucleotide sequence ID" value="XM_070202465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L1T5"/>
    <dbReference type="GeneID" id="30175411"/>
    <dbReference type="KEGG" id="kpin:30175411"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032473">
        <property type="entry name" value="Argonaute_Mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16487">
        <property type="entry name" value="ArgoMid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="2">
        <location>
            <begin position="307"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="3">
        <location>
            <begin position="559"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC67948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="922" mass="102154" checksum="D083EB22EA63AB38" modified="2024-07-24" version="1">MPPKETGTATAGDLVSGMQDLSIATRRGMQETLDGCPPRPGYGTAGRAIEVNANMFLSKFKSQGNTIIHYDIDISPVVKVANQKKPRALLQAVWDQMVLEAKGDIRKSLDAAAYDQVKSFYTPVPLPDTSTEIIVSLKEDGKDPKDDKRRFKVIIQSVNTIDLSIIEEYCRGTKQSEQTREMMLTAIQAMNILFRQDPAKQFVMSGAAGRRFFTEEGSEPLSNGGILYRGFQQSFRWTSSEHPALQIDTAYSAFIEPGMLPDVCARLLGMSGGGGFGGGRGGRGFDRGGRGGGRGGPPPRQGNGGVPAIQDLQPMQIRKVNEYLKTAKFRVTHRNSDRIFSINKITTQPAEALKFTLSGKDGKPDRQIGIIQYYKEIYNKQVTRPRLPCVQYGKNNYIPMEHAAKPPPQRQAAINAWRQRLNYSNLPKIKAWGVQVNDQMMKIPARVLNPPNVLYGGNKSMRANFGSWNLKNVKFTKPGKPLKSWSVVSFDERCGEADLQKFVTFLVDQLAAYGCVVENRQPDCFRWNPNQAGNGTGIKVGLQEAARKAYMKSKANPQLIIVIMPRKDTQMYKTIKAQAADGLLKPVVTQCLQSQKIKSDRGLDQYCGNVAMKIHVKLGGVTHQVAHGIDNKTMMIGADVTHPPPQGGLIQPSIAVTVCAVNGENNKFAPAIRLQEGRVEIIQDLENMMYDHIIAFEKNTKAKPEKILFFRDGVSEGQYGQCVEYEVEAVKRAARKFAKYMPKITFVICAKRHAMRFFAVGESDKDRTGNLPAGTIVDSKVTSPMIHDFYLQAHAGLQGTARPTHYVVVADENKYSPDKLQKLINDLCYTYSRASRSVSLVPVAYYSDIVAEKVRDWVYNEDLTETASTAPSSGSGGQTAVATFDPLRLKRRIENDPDFNSVAWVSTLSEPGSTVQVTRLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L3V9</accession>
    <name>A0AAJ8L3V9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HpcH/HpaI aldolase/citrate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_102981</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC69045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058760.1">
        <property type="nucleotide sequence ID" value="XM_070202659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L3V9"/>
    <dbReference type="GeneID" id="30171703"/>
    <dbReference type="KEGG" id="kpin:30171703"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050251">
        <property type="entry name" value="HpcH-HpaI_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502">
        <property type="entry name" value="2-KETO-3-DEOXY-L-RHAMNONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502:SF8">
        <property type="entry name" value="SYNTHASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="3">
        <location>
            <begin position="64"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC69045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="312" mass="33771" checksum="BA5C53EB52F33C55" modified="2024-07-24" version="1">MPQHPFGTPPSFGDANFAQFFGVPAAPEQDPSMLNYRGHTLHHTFDLRSRMAISREKPMIGTFYAAFPHPTVARMIGQAGYDYVLLDWEHTPYTPESIVELIKIIQYAGEGKTAVIVRVPALEHQYAAWDAGASGVIFPHISTVEQAKKAISACRFPPVGNRSGPPNAMQFGYNDGAPNGGGVFEIWGKAAVILQIEDEEGANNADALGALEEVDGLMLGPGDLAFSLGLTFADIGKDERWLSCVQKVFTAAKDHKKASLMPGMNSQQASAHLQSGVTMLCVSNDSMIMAQGLRQELVSAHEQLQAWKSTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L4U6</accession>
    <name>A0AAJ8L4U6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_104565</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle</location>
            <location evidence="5">COPI-coated vesicle membrane</location>
        </subcellularLocation>
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        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
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    <keyword evidence="4" id="KW-0472">Membrane</keyword>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L556</accession>
    <name>A0AAJ8L556_9TREE</name>
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        <recommendedName>
            <fullName evidence="4">Pal1 cell morphology protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_103225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_070202700.1"/>
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        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Pal1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307">
        <property type="entry name" value="PROTEIN PAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307:SF2">
        <property type="entry name" value="PROTEIN PAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08316">
        <property type="entry name" value="Pal1"/>
        <property type="match status" value="1"/>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="17"/>
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        </location>
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        <location>
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        <location>
            <begin position="273"/>
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        </location>
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        <location>
            <begin position="418"/>
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        </location>
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        <location>
            <begin position="585"/>
            <end position="594"/>
        </location>
    </feature>
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        <location>
            <begin position="606"/>
            <end position="624"/>
        </location>
    </feature>
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        <location>
            <begin position="631"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="645"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="664"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="685"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="760"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="827"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC69287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="842" mass="90912" checksum="8FA0C4FBD7D0485C" modified="2024-07-24" version="1">MGLPPQLPPKEYNSTQSKSSFLSPNSSNSRLSTNSKSSLNSIIDQDLAAAVRDSVQINTPKSQTIPRNSILLDTSSSSSSGNNNNNNNNNNHNKIQPPLPSLNPLIPRRTPSPNTQQQHQRQQEAKKMGVYQPTHNYSHSSPDMSIITNHQGQQPALPSARMSQISPQNPFEDDEIEPAGTGRIKPPGTGHMTNKSFGGTSLESDGMVQPHRAKFGRSQTGSIPPTSSSSHLLGPTSPTSGPKTRTRRSMSSDSYGFNGEMPAIKELTSGQKKAAEDKKGSRHADVIDTWDPTGLGSAMWHHSGPYDAAAPSRNTNLPNNRAPMQAFRAPPVQSPPPKGPTTISLSSPPVPPAKDTTVEGSDRPAHKRGQSGNRYGAPPTNRRVSGGGLTGQYSTSMPSSGGYFPNMDAPQDEATLARLERQREREAKRQALKAAWGTDTPEPFEDFGRSPNDGTIDLGSDYYSPESVSAPLPGKSARSPGLRFGMGATSPPILDQGTSPTGEYPPAITRGAGPGGVKRTKSLMQKIKTMVRHRSESMESDSNPPFRYGYGGGEGQRSMSASSGQVHKGKVPLPSPGWEDRPALVEEEELEDEIIPGGGQFDDADVFGHDRRRVVSDGNNRENPRSSSPNKASSNEINPSISAEHPSEYHQDKSKRPGFFARTSGNQSSSGGRNSPNKKPILPHNSFSNSSIPTTNSITTPNDVFAEVDESLKDNLNKQGNPEDFEKIIPSTAGSGFILVESPSSKARVLKALQKEQQHNHHHHHHVRSNSHSKHDENGISTIPANRAKYLPTPPVAPVMPDFNDILAPTRKTSPMELGVPEEGGLKRKTSMVKKLKDRMNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L5A3</accession>
    <name>A0AAJ8L5A3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Protein PNS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_104390</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Probably involved in transport through the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059042.1">
        <property type="nucleotide sequence ID" value="XM_070202941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L5A3"/>
    <dbReference type="GeneID" id="30172398"/>
    <dbReference type="KEGG" id="kpin:30172398"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF4">
        <property type="entry name" value="PROTEIN PNS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="311"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC70439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="570" mass="61994" checksum="25463E2B644F45B8" modified="2024-07-24" version="1">MSAQQYYQNGTGDVGQYNQQRGYENNYAQQGYGQQQQNYPQQQYQPPPGPPQEQGQGGYNMKPSQPYAPPPPQEQQQQQQTGGYGENGAPPAYVDTAPFSQADEKTGQRLNPKKRLNDPIFLVLFIAAVAGFAVLSGIAIKSFINVGGLGGGFGNNTQGGTGSSVTLDYHTVYLLLCVCALGLVLAALYLALVRAFTRIIIEVTLALTVILNIGICIYWSGAIIFLIIALLSVFFYWSMRKRIPLAKLLLQVTIDITKHHPSVYLVVLLGLIVQSALSVWYTFTCIAIYVKWTPGSESCTGTSCSSGKVAGLIFYSTFAYLWMSQVVANVILCTLAGGIFGGWYYYGPRVPTGGLPKRATLSAFIRASTLSLGSIAFGSLIVTLLELIRLILQAVQQYEAGEGDMIGSIIACCAACCVGCIESMIAWFNKYAYIEISLYGKSYIPAAKDTWRLLKDRGIDALVNDSLVGTALMWGAYINGFLCAVLGYLYLRFTNPAYNSDGQYSAPVILFSFLIGISEGQVINSAIDAGVSTIFVGLGEDPMVLAERSPALFEMIRQTYPRVIEGVPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L5G7</accession>
    <name>A0AAJ8L5G7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_103874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC69930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058945.1">
        <property type="nucleotide sequence ID" value="XM_070202844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L5G7"/>
    <dbReference type="GeneID" id="30172922"/>
    <dbReference type="KEGG" id="kpin:30172922"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="687"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="548"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC69930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="724" mass="80652" checksum="E0100C729A2A10BB" modified="2024-07-24" version="1">MGTPYNNASSSLSRYPSTHTNSSFLNHVYLDFDHPIPESPTISVDSSSPFISELTTATSDQTELSRITSHGNDEYEDLEDTQACLRKNHHTSLSAVGGGTKPLRVKKKKGVTAVKVGHSSKAKKRRSTLSFPHSPFTRESYSPIMHYRGNTNGPKRNLSTTSDQSNISRTHANISRIFLSMQTFNSPSPTNENINFDIERMKLERIFSNSSLHLGLGKFDEFDPMVKPGPSPPNSPQPSPIKRSFISTSPGLIVDDYRSKSLPNPPSPLTPSRAPRKAAALLGASTIHQQPKIRNNNRIHGLNTKHFRPLPNSTLNEIEKFFGDLPKKPSKIPSGLKAKPKMKSTGDEGGIGDRNVGQGEIVKYKAEDGSMWLDVEEEQEFAWLLSEIFALHPQPLPNLTKINSNELESFDGEDKWEMENFTSILSLPKPKTIKSDEPKSIRRIKENDNSFLNLETAKPTRGYKTTISENKFQSNPWSFNGEENMKHKRSISNPISSIPTIDKLSISPPMPTLIPPPRISSKSNIATNERLSTSMPSNKQFIQSENEFSSGFSSDSSVESILSNSPPSFGRKTKTRPPPLTLKRIKPSSKLPILTATSPQNQIIKQSTHQPRIISTNGTSQIKSDTIKENQNPKDDIPNTPFIRPRIAPKPVHNDNDSFPPVPNLPLILPKDIKDSKVNEEPISFFEPITPIQPNSSQNRINLSNGMMKEKKSWLKRVVKSVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L5V9</accession>
    <name>A0AAJ8L5V9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_103605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="Mohammad A.W."/>
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                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
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                <person name="Heitman J."/>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
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                <person name="Zeng Q."/>
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</entry>
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        <location>
            <begin position="316"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="366"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC70967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="570" mass="61261" checksum="2EA6B71F4A8FB106" modified="2024-07-24" version="1">MTFLTNTISKLNTNTLKQPKQSPTLSHLVSSASLSPTSSISSYQSYFDTRFVGTSFDGGERRESACSNTSWGSMGETTSSKQPDKEDIPMEEDENCIDNVAEETLNLTQPIHSRILSNKSVDSIASSHSSSSSSSEPKITTPEFPNSPGSVNPFFPAQNGQPQISPSSSTTSKATSKDEYTPRAELPALHWPHASASSPIRKSDHHTDGQSVMQDQEQAFSTVRKPSIRRNGSWRRKHASLDTPPTAPHLAPSFPGFTALKHTPPLVPAVSASKQHLEGLPAQPEGRLAPPAQGQGCGMDASSPDVRRLSGESFRSIGSGNSIIAQSPTTGCEISAPKAPPAGYPLPSLGIQRRSSVPGQFRSPVSSTSSTSATSSSSSSCKSNRLATPPPLPPRWACPPAKTNAVSGRALSFGSSQDRPDVSFDDFDPELFEGKENEWIEMIKGVEGRIAIKSTAQFYDIMVWLPGFSLDNITIATRGTRTVHIIADQWDEGDHAQWDIKLGEDANLKSVNAKFSGGELRVTVAREQRFTNPKLTRMLSSRSSIGPTFSSPSISATTGHNPLERATVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LAB8</accession>
    <name>A0AAJ8LAB8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_106380</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059406.1">
        <property type="nucleotide sequence ID" value="XM_070203305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LAB8"/>
    <dbReference type="GeneID" id="30175552"/>
    <dbReference type="KEGG" id="kpin:30175552"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF19">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC72418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="406" mass="46165" checksum="23285B5A822C3801" modified="2024-07-24" version="1">MAVDLDLSTLRSDYDQRRNRDRQRIWLALYAADKRFNYCGQTAKPSMMPEDNLIRSSENFIYSPICIPVDYRLASNVALRRVLSVSIEAIDKDNESGPGSYDLDLRSVYHTFEKDSEAWVKTQTERDPEIAIHANLSALHAKVIISHRWVQRSFRNLNSSGDPGIEENQERERREALAYCINGSLACLATMCELQDDLLRFTCDSKHLYFAYASFFLFKVFDTNIATTILDQQSLSYIFGLFQRSADKLERLAISTTHTIAFHAAFLRRLSRFDTGNPSNFGQSAQNPPVLDHGASIPQSIYNDVKAPPVINATSLVAEQSQTLQALSQPELGDPTFEFSSFDPLPELGNWLLENSTDESLGANINWNDWWPFDDDISWNFTNRNQDGIGLDNTHDTEWQGLVHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LB29</accession>
    <name>A0AAJ8LB29_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cadmium ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I206_106369</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059403.1">
        <property type="nucleotide sequence ID" value="XM_070203302.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30175541"/>
    <dbReference type="KEGG" id="kpin:30175541"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18597">
        <property type="entry name" value="ABC_6TM_YOR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18606">
        <property type="entry name" value="ABC_6TM_YOR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001172">
        <property type="entry name" value="Cystic fibrosis transmembrane conductance regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000010">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF415">
        <property type="entry name" value="FI20190P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="232"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="826"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="867"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="937"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="963"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1052"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="190"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="535"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="829"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1142"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="130"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WWC72407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1429" mass="159475" checksum="0688CA16D4138C35" modified="2024-07-24" version="1">MSIPFYRPIPALQGIYGDQILPEGKASLLSRIFFHWVTPIMRAGYSRPLEAEDLWVLTNDLECKNVADKLQQHLNEQNSSTTREASNEQSEKGHENRPIKQNEFRYSRDSIAVLDTVDGYSVQNPSIKLESTHPANTHRSELTNIHGGPNSTLSSSTSDIHHESQAAEINNRPSLLKAMYMTIWWEWWKAVIFKGLAAALQITAPLITKLLIDQLILSHNFHQDPSKESPKSIGYIIGLAFGLFIMVQSASLFSYQALQRGSVIGFKMRAALIDLIGRKSLKLSSRSKVEFTSGKLTTMVSADASFLDFSAPMTLDLIVQPMQIAVGLGLLIWTLGYSALVGLAVLTLAGPLQAYMFKRMIYTRQHQLKYVDSRVRVLSETITSIRSVKLFSYVNFFSEKVTDLRKNELIYLRQNGFNRATMNATMAVIPTLAAVLTLVTYGLSGHELNPAVIFSGLQYFNVLKTPISFLPMCFTAVSDALVGIRRIGALLQSEEIPPKLNIVDKSRYAIDVVGDFQHESLPVINASMQSMPPAERNEEKRSTSNSEPFALRGIDLKIPRGSLVCIIGRVGSGKSALVSSMIGDMRQLFGHTIFGGSVSNVPQQAWIHSGSIRDNITFSATSREIDYERLRIVINACALKNEVEEMANADRSNVGEKGLLLSGGQRQRLSLARAAYSQSSIVIMDDPLSAVDANVSHHILKECILGGPLVGRTRIIVTHQMDILPHADLVLVMDCDASGQGKIVQKGTYQYLKNQEGPFKSFISGSLHNPSSPSIKPVKAKATYEKVDKEKNQVNQVTDGMDEDRQIGSIPWKVYTTYFKAMGTTFWPIAFGIMLLLTQAATVGNSLWLGWWSANKFDLGQGGYMGIYAALGVSIGLFTWGASYTMFIAGLKASYRLFERAWEHVMRAPVKWHDQTPSGRIINRLSKDVEMLDDRMAFSWETLLVNALAAVGTFGLILYTYPYLGIAFIPLVLFYWLAGSYYRQTSREIKRIDSITRSQIHSSFGEQLSGLSVIRAFGKQETFEDRLQKAINIEGRAYILTLVIQRWLGVRLDLSSNLLVLLIAIFGILFRNTVDAASFGVVFSYALSAAQLFSNLVSLYAQVELEMNNAERILHYTTLPSEPSAYLPKDPPENSWPIKGEMKFRNLSLRYSEFSPWVLKGLNFNIEAGEKVGVIGRTGAGKSSLINAIMRMTDIKGQVIVDEKNLNEIGIDTVRERIGIIPQDAFLFQGTIRNNLDPTGIHSDEYLNSLLNLIQSDSLLPSSKSIKEKFKLDSQVNFEGSNYSAGEKQLLAFIRALARGTKILLLDEATSSVDPETDALIQRIIQNHLQGVTLISIAHRLQTVAYYDRILVLDQGKVAEYDTPLTLYDMRDSIFRQLCDRVHLRRIDLLRLRHDALYALQSSRDDTSLFNHFTITEAWAKNGGVKVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LBH5</accession>
    <name>A0AAJ8LBH5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ADP-ribosylation factor 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_106160</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059365.1">
        <property type="nucleotide sequence ID" value="XM_070203264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LBH5"/>
    <dbReference type="GeneID" id="30173354"/>
    <dbReference type="KEGG" id="kpin:30173354"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04149">
        <property type="entry name" value="Arf6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000286">
        <property type="entry name" value="ADP-ribosylation factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041838">
        <property type="entry name" value="Arf6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 9 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC72200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="182" mass="20511" checksum="5BC0CD458F551E8F" modified="2024-07-24" version="1">MGGQLSKALGKLFGNKEMRILMLGLDAAGKTTILYKLKLNQSVTTIPTVGFNVETVTYKNVKFNVWDVGGQDKIRPLWRHYYTGTQGLIFVIDSGDRDRIDEARLELERILADREMRDCLLMVFANKQDLPGAMSPAEVTEKLGLHKMRDRSWYVHPSCATTGEGLFEGLQWLSQNVKGTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LBK3</accession>
    <name>A0AAJ8LBK3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mannose-1-phosphate guanylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_106596</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>alpha-D-mannose 1-phosphate + GTP + H(+) = GDP-alpha-D-mannose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="EC" id="2.7.7.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.13" evidence="3"/>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059451.1">
        <property type="nucleotide sequence ID" value="XM_070203350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LBK3"/>
    <dbReference type="GeneID" id="30175882"/>
    <dbReference type="KEGG" id="kpin:30175882"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06425">
        <property type="entry name" value="M1P_guanylylT_B_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="mannose-1-phosphate guanyltransferase beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
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        <property type="entry name" value="GMPPB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="Nucleotidyl transferase" evidence="9">
        <location>
            <begin position="8"/>
            <end position="227"/>
        </location>
    </feature>
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        <location>
            <begin position="251"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047343"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC72632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="366" mass="40176" checksum="83C4040715109689" modified="2024-07-24" version="1">MKINTTIRLRPLTLSWPKPLVEFCNKAMILHQIEALVKAGVKDIVLAVNYRPEVMVSVLKKTEEEFGINIHFSVETEPLGTAGPLALARDILGKDDTPFFVLNSDVTCVYPFEAFRDFHAAHGAEGSIMVTKVAEPSAYGVVVTKPGSTVIDRFVEKPVEFVGNRINAGIYIFNPSVLNRIKLEPTSIEKDTFPAIAADQQLHSFDLPGFWMDVGQPKDYLSGTCLYLSHLTSTHSPLLTDPKTNKWVYGGNVLVDPSAEIDPTAVIGPNVVIGPDAKIGPGVRLQRCVILSNAVVRDHAWIANSIIGWNSNVGRWTRVENITVLGDDVTIKDELYVNGASVLPHKSISTSITEPRIVMCKCNFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LBS1</accession>
    <name>A0AAJ8LBS1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chorismate-utilising enzyme C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_107209</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_070203476.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="96955783"/>
    <dbReference type="KEGG" id="kpin:96955783"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
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        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:L-tryptophan biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Anthranilate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
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        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AMINOBENZOATE/ANTHRANILATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236:SF48">
        <property type="entry name" value="ISOCHORISMATE SYNTHASE MENF"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
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        <property type="entry name" value="ADC synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="5">
        <location>
            <begin position="3"/>
            <end position="65"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC73243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="87" mass="9362" checksum="08C64077063C7B61" modified="2024-07-24" version="1">MGLEEARRGPYGGGVGVFDFDKNNMDTCICIRTIVFHGGSAHIAAGAGIVADSVEQSEYEETVNKAKACVRAIEQAEQYYSDLQSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LCP3</accession>
    <name>A0AAJ8LCP3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin-conjugating enzyme family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_107580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059649.1">
        <property type="nucleotide sequence ID" value="XM_070203548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LCP3"/>
    <dbReference type="GeneID" id="30174282"/>
    <dbReference type="KEGG" id="kpin:30174282"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23810">
        <property type="entry name" value="UBCc_BIRC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116:SF15">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBA" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="639"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="40"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="505"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="68"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC73608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="883" mass="97493" checksum="D446C6D6942FEA20" modified="2024-07-24" version="1">MPDPALVQMMDMGIPGARARAALKKSKGDVMSAAEKVFQGDFDDIPSDDDSEYERASSSKSGGVILIEDSDIDMEEDSDGSEADDEGFAGFEDDGGVSEDRLLSDPYAGIFFSKDRVERIMEPVEEDRYVKVILTQGQDEHVKVLRRAAWMSGCPEGSEQSFLFQLYSTLAEGSMPCSAGCGHQFSRHEKDFFLLFSDYATYTTYLNSKIRPICPQCSQATCLACGERVNDIGPFDEKGKNPFLVSNDVLLHCPNLQGVLLGVGLHMIEQAFSTQHESRSLTTSIANPPSKKQNAGAIHDNLKKTGIPKASSKDGNGHVVADAESAVKISSKGTGYSGSSKEDRTGQVKAGEAQKAADERILLLLSQIQIFLPNLDRVGGPKTSDHLVHPTALAHLRRRSAFINDLLRNDSLLDMSQRAELYTSLLDWLKLVSNHEALASMLAMPQMRPVSIAPCPDSPGFITVTYEGSSSPRELLENCVIQAQAALKGLQAVSDISKPKEIDMTEEEKRLSRAEVARREREQKEGERLDANAQLRTFCEKIVYSAQAIDRSLIETKGEPFVERMKESLPRLPKVGVLVEEQSVTGLTEEAKKKIYEKWAGRARFQYCDLTEPSTVDKKAYRHAFDGSIQSLEGMDMPKRSLAIAKELAILTTSLPVAWHSTIFLRVDETRVDVLKAMIIGPEGTPYENGCFIFDIFLPLDYNLRCPHVKSMTTNGGKYRLNPNLYADGKVCLSLLGTWQGPGWISGQSTLLQVLISIQSLILCEEPYTNEPGWANDAGTPASKAYSANVRRMVLVDAMANNIKRPPHPFESEIKTHFRLKSRSIKQQIGNWRKLDDGKPISGDSYSSGLGQSDKANFNNAAKEVIRLLDQLENVKSIINDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LDJ8</accession>
    <name>A0AAJ8LDJ8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_107216</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC73250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009680.2">
        <property type="nucleotide sequence ID" value="XM_019156962.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LDJ8"/>
    <dbReference type="GeneID" id="30173609"/>
    <dbReference type="KEGG" id="kpin:30173609"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00413">
        <property type="entry name" value="Glyco_hydrolase_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121:SF4">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042525216" description="GH16 domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="34"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC73250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="295" mass="31674" checksum="2A7204417929A708" modified="2024-07-24" version="1">MLLVTILISIFTVLAIATPLNPRATSCSCGYVLTKYNNVYFPKSLTVSFDKVNSLSALQAAGFEINTGWQMGTSAEDGGYALGSSKNIGFKDGYLTLTVPGGQKKGKSITGAEISTKTIFGGGIFTMNAQLSKVPGTVQSMFSYTSNYEKFGDEQDIELLASSFLTANPDNGTPPGIELTNYAPDNSGNNEETIVPFPNNPTEGFNNYTIGWIKGGTQYYYNGKAINSPKKYSSINPSYIILNNWSSGDPNFSMGPPAQDSVLKVKSVTFYYQTQALTSYPAYPSGCTQAKACVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LE39</accession>
    <name>A0AAJ8LE39_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_107491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059632.1">
        <property type="nucleotide sequence ID" value="XM_070203531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LE39"/>
    <dbReference type="GeneID" id="30174188"/>
    <dbReference type="KEGG" id="kpin:30174188"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042608526" evidence="1">
        <location>
            <begin position="20"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC73520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="275" mass="29782" checksum="39948BB20DCF2E75" modified="2024-07-24" version="1">MRSYLFAFLTLLLLTFVQAQPTRTHDDEPGKRVPLRARAARSFKRSLCSTNAECLRKGLPLLRPFRRGTRTRSAIRPRDSPAADEETGSLQVFDANGNSLGYVSKVIDDNSGGYTITTDPTEAVSLSFTSDGSNPFTITISSSDRQAGFPYLGGVFNDNTSNMGTGSSAFAVLGGLSRTISGPAVSDDTGEDNTRQLYGGSETSIFLYDSNTQAITGQWTNTDDTKVDTIFFYGSDEGYDLGMIAPEDYDAFANNFDANPQKVTIKFVTTPTPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MJY5</accession>
    <name>A0AAJ8MJY5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Nuclear DNA helicase II</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_100127</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058241.1">
        <property type="nucleotide sequence ID" value="XM_070202140.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30169569"/>
    <dbReference type="KEGG" id="kpin:30169569"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00048">
        <property type="entry name" value="DSRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001714">
        <property type="entry name" value="ATP-dependent DEAD/H RNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001627">
        <property type="entry name" value="Nuclear DNA helicase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000002">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF203">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HELICASE_CTER"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        </location>
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            <end position="1029"/>
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            <begin position="1"/>
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        </location>
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        </source>
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            <dbReference type="PROSITE" id="PS51194"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MK74</accession>
    <name>A0AAJ8MK74_9TREE</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">I206_100398</name>
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    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 10737</strain>
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</entry>
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    <accession>A0AAJ8MLW4</accession>
    <name>A0AAJ8MLW4_9TREE</name>
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        <recommendedName>
            <fullName evidence="3">GDP/GTP exchange factor Sec2 N-terminal domain-containing protein</fullName>
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    <organism evidence="4 5">
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        </lineage>
    </organism>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="WWC66484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144284">
        <property type="entry name" value="Sec2 N-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="90"/>
        </location>
    </feature>
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        </location>
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        </location>
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        </location>
    </feature>
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            <end position="930"/>
        </location>
    </feature>
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            <begin position="685"/>
            <end position="748"/>
        </location>
    </feature>
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            <end position="143"/>
        </location>
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        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
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            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
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        <location>
            <begin position="233"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="282"/>
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        </location>
    </feature>
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        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
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        <location>
            <begin position="338"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="442"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="485"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="767"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="861"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC66484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="958" mass="101354" checksum="E6A8180CE1F3F27B" modified="2024-07-24" version="1">MMHAGGGVPSMAYYSYSNQNSPVIETANNDNPFDLANMTIPPRLKSIGRKISQMSNDFMPPDIEDPNTRSKPASPNLEKKQPLGAEVPGMGDEPIMCPFCNKPLPPSLVASQMTSGKHDHTSAPQRPNNLKRASSMRVTSTPSPKLIPSAPLSRVTSANTPPQTQKPTPLLDPLPVQTPGSTKPVEPEPPIPSATSESFAATVKEGDVANHDAAEKMITEEDIKRWSSLSGITLPSTSAAHTASATQSVPQEQKAFPLLPPPPPAASKLTKTPPTERTHSRSSSAKFGFFVGSKKGGEEDEDSEDDDGMATGYTKLTGPASDSEDEEPSQKGGVKLNISKEEIQQQEKKAEEEVEKADVQSAQPEQVEPPRQSVITASAPSAGDGEIRKVLQEVLERVNDLSKTQTALLASHSTLLTSLKIARSNLAMAEANSEMLEEQLKRASTSSNASRTGNSRNVSGPATTPGTPLPVAPQPARASADHVRATTTANATATPAAVTGRAPARASMEDRPRPTSLYVTANDLANAGPGGLSAPSPSSSNNSWGFWNGGKKKVTGALSHVHVPSASSMMDAIGNPSRPGTPNPDGSAPRKSTDSISSWIPSSPAAPYSVPISGNAPSRPPANRTVTHHANLSKSFNDQPSLSRSMSVMNVPAQRSASGSAAAVSVSNAELSKLRQAYSAAVAKMDGMSKELAELKTGKVEMEAELENLSQALFEEANKMVADERRKRAELEEFFKEVKEEREALRETIKVLGGKVEEPSNPPPEGSTEDSKEEEEEDELADDFVPRDLDKHYAALRKSIHHVAARADSSEDEDEDEERRASVPLVSEPGSMTPIATTGGFAIPTSRTSTMTSDEGEDNSSHMLSMSMPSLPAAAESNPWATPAMTKMTPFETPAPRISVKAATPSPHAPPVGLPELPDDSAGEGEAISGLGLDIDKGVVAGEAEAKKEEPLEPLQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MML6</accession>
    <name>A0AAJ8MML6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_100815</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058383.1">
        <property type="nucleotide sequence ID" value="XM_070202282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MML6"/>
    <dbReference type="GeneID" id="30168881"/>
    <dbReference type="KEGG" id="kpin:30168881"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052631">
        <property type="entry name" value="Paired_homeobox_Bicoid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46255:SF3">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46255">
        <property type="entry name" value="SHORT STATURE HOMEOBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="4">
        <location>
            <begin position="306"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="1">
        <location>
            <begin position="308"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="142"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="276"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="369"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="458"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="537"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="720"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="160"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="484"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="537"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="738"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC66908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="785" mass="87359" checksum="1E24878E164EBE95" modified="2024-07-24" version="1">MPLILHSGVIMGSGDRSIRSLPGVSPSFQSRLFHRHDDIPANQQRRERPRSEYDHPLPPVAGTSDSMNYHHSFLPGSEFCEPGPSHSTSRFRPSRPGLKQDAFNQIGPSRLAPYVPADQRYHAPRPADRQWLGADGRRSEIQERPVFPPPPVPAPPHIVASSSRANMQASPTTRERPYSSPFPRRRYSQSPEINTASMQAFNDRPYSSRLPSMGQTSMSAGHFPSNRSSEASHSHRLVSMSPSRYTHTIPADFGHSLSRTFSNESTHSHHSYAMQRDLSGGSSMSGSSYTGTSSFQSGQPYPGGGYKKKRTRALMTHMQQSGLMKLWRKTKFPTGADRERLGQEIGLTPRQVQVWFQNQRQKGRKTLAVNGGIPEGEDPANYEDLQKSPRSRRLSLEGDERISAWTGESSNTASSRFLLDPPSAVSPSHNEPLIRHSRHFPHPYLQEDPASRSVISLPTTSSHENWDHTRPGREPKGKERAQDPTKQSYPQNDPSSHSKSHPDLILRSPESYPSLHSRSRSLHNLLLPSIDTQKYASPSNYDQPLSSYDTIHPNAISPSDKPFPSVLEPLYRPARPSKTSSTPLPPIISPLSAGRSFRSDTRHNQSSGTPPLKRRRTSPETGTNFRFDGATNFTKPRPHMGDDKGVLDQESERERLGSIRKFGLPSSHLPPELARIALRAPYHSEREGDDDYNLPGIDDQLFSPSFQDGDAILSPIDHVSPSNQGDDVDVAQVPIETGDYKSSKKPPEDTQHDLGHDQAVMNEIGVAEETPTIKPISSNLRNLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MNK0</accession>
    <name>A0AAJ8MNK0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WDR5-like beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_101599</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058522.1">
        <property type="nucleotide sequence ID" value="XM_070202421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MNK0"/>
    <dbReference type="GeneID" id="30174800"/>
    <dbReference type="KEGG" id="kpin:30174800"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059122">
        <property type="entry name" value="Beta-prop_WDR5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25175">
        <property type="entry name" value="Beta-prop_WDR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDR5-like beta-propeller" evidence="5">
        <location>
            <begin position="30"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="31"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="126"/>
            <end position="167"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="282"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="Pfam" id="PF25175"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC67687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="376" mass="40970" checksum="7F69FB8EE7939D81" modified="2024-07-24" version="1">MAISPTSPEVIQANAEAGPSSGPKYILSQTLSAHKRAVTALRFSNDGQTLVSAGADGWLHYWDPETGDHIRGFKAHKTGINDISISPDSLYISTASDDSTALIHYLNPPPSPSTSIADQNEPLRTLIGHTAPVLTIAFSPKSNLIVTGSYDESAIIWDVRKGKILRNLPAHADAIWCVGWDNEGAMVLTASSDGLIRLWDVNTGQCLKTLDNDTNSPVSYASFTPSSYFLLSSTLSSTLRIYNIHTSKVLKTIQSPGLYLSEKFPCPAIIFNSPNQEEKMEINNNNNNNNDQSISINDNHQNNQNSNSIASKKDTWIISGSENGKIIIWDLQLKSVIQILEGHNSTVVALAVHPNGRLIASGTLEPEKSIKLWRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ8MPW0_9TREE</name>
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            <fullName evidence="4">RING-type domain-containing protein</fullName>
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        <lineage>
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            <taxon>Agaricomycotina</taxon>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
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        </source>
    </evidence>
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</entry>
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                <person name="Heitman J."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
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                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
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                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
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                <person name="Pearson M."/>
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                <person name="Roberts A."/>
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                <person name="Nusbaum C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="7">CBS 10737</strain>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50089"/>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="510" mass="53598" checksum="4B896A6F49635169" modified="2024-07-24" version="1">MPPPAPFWLCHECGAQMRPVMVDGVSHCASCNGEFIEILDSEVNPDPFHELPPPPPTRPNQSQLSPSRNTPQSPSRQYADPGQGGQSFFSSFIGNILGAAADHSQGEGSNSSRQDQGRETSPTRNTGGSGTGSGRTFSFNFPGGGRGQVMFGSFNGAGMGGMGGMGPFGPIGQGRTTGGMGFESLFPQGFGPPPRAGSGQHGRPHPLGPGDPMDGGELLRALMAVMGEEGQMGPGMFFGGPGRGNLGDYATSEQGFNDILERLMQAAGPQGPLPASDIVINGLPRFKFDEEKKLAQSTYKDCPVCKDDFAIGDEVVRIPCAHIFHPDCLIPWLKQNGSCPVCRFSLVPEEEDRARRSAAPPQSNTTSAEGTANSAQEGSQSTMTSILNRLFGQAGGTTSNPTSPTGEESNHLPFGAAGEATRPAPSTTAVQAASSGDVSRPRSVPDGMPPTDQSGQQSGSSSRQHNNEDPPSPTLPASGQPSLSTAIPEDYRARHRERERQRQQHEDTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MQ01</accession>
    <name>A0AAJ8MQ01_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_103577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058894.1">
        <property type="nucleotide sequence ID" value="XM_070202793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MQ01"/>
    <dbReference type="GeneID" id="30169787"/>
    <dbReference type="KEGG" id="kpin:30169787"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC69634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="212" mass="23732" checksum="71E963BB92C3C3E9" modified="2024-07-24" version="1">MGNTFSTVKWESPTGGKFRIYSRFYDVYGLGNWKPVEVEERIVGHPAFERVGQCLVMVELKSNGTHEIEFRKQRAWKDKQVRFLDCALDGLPAPYHWWGLVIIRPHLRIAKEAADKIASATGRSVIISAQDPLSEIVQEKQIVKKKVTIAEEPQKKAASSGDKETEVEGKKVEMIVEETTTTVEKQPEVEAIAAGSEGSKKSQKKGKPLPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MQL3</accession>
    <name>A0AAJ8MQL3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Short-chain dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_103745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013191.2">
        <property type="nucleotide sequence ID" value="XM_019153030.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MQL3"/>
    <dbReference type="GeneID" id="30169625"/>
    <dbReference type="KEGG" id="kpin:30169625"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF9">
        <property type="entry name" value="OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC69802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="30436" checksum="137766152AD176F8" modified="2024-07-24" version="1">MTDATSALSTLSVPRLFSLAGQTVIVVGGGRGIGASVVLGCLEGGANIFVLDLLPEPDKNDWPPAKATAEKNGLKLNYGVADVTNEESLKMGFQTIFDSIDESSAPLRGLVVTAGVPIPISGLELEYDQWKRGIDVNLNGSFLSCQIFAKEWINRNPKVNSSDPDSPLASIVLTSSIHGQGFNRQVPGPSYGSAKAAIKHLASILGAEWGARAIRVNSISPGLIVTSTMRQNYIPTHPEYVDNMTKFTAIKRVADASELKAPVVFLLSKGSSFVTGTDLVIDGGHLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MSA3</accession>
    <name>A0AAJ8MSA3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_105515</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011482.2">
        <property type="nucleotide sequence ID" value="XM_019155328.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MSA3"/>
    <dbReference type="GeneID" id="30171951"/>
    <dbReference type="KEGG" id="kpin:30171951"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36460">
        <property type="entry name" value="UPF0132 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G10255)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36460:SF1">
        <property type="entry name" value="UPF0132 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G10255)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC71557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="206" mass="22559" checksum="B246BD896B201C5E" modified="2024-07-24" version="1">MSVNFSPYQPPPDVPSTDPPESSSKKGKSKRPWFTRDQSSYSPNSYQSGGSISDPTSQAQAYSNDPEAAGLLNGGIGGGGGGAFGEGDRANAWESRFGWRVDFMAAGTYLGGPITALLFLILETQNDYVRFHAYQSALLTTPLLIVFLIFKLIIPLPTFLRVIYILAAIGGTLYTSFRAWKDAQEGLSRYWIPYIGEIAERWVGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HSX8</accession>
    <name>A0A1B9HSX8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_07594</name>
        <name evidence="8" type="ORF">I206_102226</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">CBS 10737</strain>
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    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="5" key="3">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="6">CBS 10737</strain>
        </source>
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        </source>
    </evidence>
    <sequence length="595" mass="65184" checksum="3FDE8022A4760534" modified="2016-11-02" version="1">MSELQQVLELLKKLDTKQEELAAQIETIKQNQSTFQPNPSTYPLINSNSTPSTPIIPAGTEIIPCSSIPSSPRTNSGGVEQLRLTRGSFSSILQPSSSSSLLSFSSSPPNTNTNTNTNGNGNGNTTPYGNLSLEAITHGSGAPGRLSPPSGTEKEKDGGKKKGYPSRVVLTTYPSQAGINPIPINWGAGPTARERGPVVCSRIKSNLLIRNSIGAHSGSYSIYRALSIAMGQLRTDWRPDLTNTHPPFVLPPTEGWFGNKIVSFDPWGAMSQEIWAKEYAEGLDVRPTISQTKAHIKIEELDALARKGEFPVDGDIVIKSPELAAFPGVDQGVEVNTYKAAVDPVWYLPGVADRLGIDESILRRALFEDTGGMYPELLTRPDIKIFLPPIGGMTIYIIGDPSKLKDPSTEITCRPHDSCSGSDVFGSDICTCRPYLIFGISEAIKCAQRGGLGIIIYFQKEGRALGEVTKYMVYNRRKRQGDSASEYFNNTEIVAGIKDARHQNLMPDILHFLGIKIIHNLISMSNMKYDAIIKSGIKVINRYEIPEELIPADGRVEIDAKIQAGYFSKKEMTEDKVKLTKGRDWGELSIEFEYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HTQ0</accession>
    <name>A0A1B9HTQ0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribosome production factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_07492</name>
        <name evidence="4" type="ORF">I206_106617</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894016">
        <property type="protein sequence ID" value="OCF46639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007858.1">
        <property type="nucleotide sequence ID" value="XM_019159186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HTQ0"/>
    <dbReference type="STRING" id="1296096.A0A1B9HTQ0"/>
    <dbReference type="GeneID" id="30175861"/>
    <dbReference type="KEGG" id="kpin:30175861"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF3">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="176"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF46639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC72653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="448" mass="50662" checksum="7964EA31C1E389CE" modified="2016-11-02" version="1">MARDKKIKNAFKRSDEHRKSKREKEQAKLARRLEIKKAEQNKENGAALKAARLAKNIPRTLDNTRHFDATSYLTADPATLRDMEEKAARASRMINGEDPEEDEESEGEEDDDEEGDEDEDEEMPEAGPSVPKSKAQRTQAEQEDEEVAEDDEEGAEEEEEEEQQQEIISDQPLLPPRILITTSASPCKLTYNFVDDLKNVFPGGESFKRPRGKGFEIGRVARWAGKRGYQALIVVNEDHKAPNAITLINLPAGPTAYFKLSSVIPSANIYGHARPSPHSPELILNNFTTLLGHSVGRLFGSLFPPQPQFRGRQVVTLHNQRDFLFFRRHRYMFTSATSATLQEIGPRFTLKLRWLRKGLPSVTAPDGRAPAGENDDDIDVSSDEEVDDAEVAAREKKDEDEAMAEMGMPDKQKKQKENGVIVPGLAEEGEYEWKWKPKMEVSRRTFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HUF2</accession>
    <name>A0A1B9HUF2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">2-oxoglutarate reductase</fullName>
            <ecNumber evidence="4">1.1.1.399</ecNumber>
            <ecNumber evidence="5">1.1.1.95</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">I206_07277</name>
        <name evidence="18" type="ORF">I206_106472</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="1.1.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(R)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.399"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.399" evidence="4"/>
    <dbReference type="EC" id="1.1.1.95" evidence="5"/>
    <dbReference type="EMBL" id="KI894015">
        <property type="protein sequence ID" value="OCF46890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008109.1">
        <property type="nucleotide sequence ID" value="XM_019158971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HUF2"/>
    <dbReference type="STRING" id="1296096.A0A1B9HUF2"/>
    <dbReference type="GeneID" id="30175646"/>
    <dbReference type="KEGG" id="kpin:30175646"/>
    <dbReference type="OrthoDB" id="1621027at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061759">
        <property type="term" value="F:2-oxoglutarate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04901">
        <property type="entry name" value="ACT_3PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12176">
        <property type="entry name" value="PGDH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000036">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000041">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050857">
        <property type="entry name" value="D-2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008759">
        <property type="entry name" value="PRK11790.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="15">
        <location>
            <begin position="110"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="16">
        <location>
            <begin position="215"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="37"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OCF46890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="WWC72510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="527" mass="57403" checksum="F0C02ED111CF1A8D" modified="2016-11-02" version="1">MSNSVPVPGRRTSVSASDPPNFIPIPTNTRGLPISSYGAQSPPATSHMASLGTSPRAAYSTSPSTSSHLRAGSGSLTSAFQGMARQLTAFLPKTYPLEEEPEKRQGTTKVLLLENINLDAAEFLKNQGFEVDHVTKAWSEEELIAKLPNYHAIGIRSKTKITQKVIDANPQLLVIGCFCIGTNQVDLEHAARRGIAVFNSPYANSRSVAELVISEIIALSRQIVDRTQEMRAGIWNKISKNCWEIRGKTIGIVGYGHIGSQLSVLAESFGMQVVYYDVIPIMPLGTARQVDTLEELLGKADFVTLHVPEIQDTINMIGEAQFAQMKSGAFFINNARGKVVDLNALASALESKHLAGAAVDVFPKEPGSNGPGFNETLGEFIPRLRNVSNLILTPHIGGSTEEAQRAIGSEVSNAVYRYLTFGCSLGSVNFPEVDLRSITIKDDRHIRVCHVHRNEPGVLKQINNILADHNIEKQFTDSKGDIAYLMADISGVGQEEVEGIYSAIKNTRANILTRLLCELPFDNILLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HVE2</accession>
    <name>A0A1B9HVE2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_07009</name>
        <name evidence="5" type="ORF">I206_101900</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700117">
        <property type="protein sequence ID" value="OCF47231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008450.1">
        <property type="nucleotide sequence ID" value="XM_019158704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HVE2"/>
    <dbReference type="STRING" id="1296096.A0A1B9HVE2"/>
    <dbReference type="GeneID" id="30175378"/>
    <dbReference type="KEGG" id="kpin:30175378"/>
    <dbReference type="OrthoDB" id="2575974at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628132" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="29"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF47231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC67981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="617" mass="65397" checksum="F4F85C538D2DCB38" modified="2016-11-02" version="1">MGHNPLTRAMTLVIPILMILHWPHLALAQSSTTARNPLSTSTTLSPSTTIYNGIPTLVFGSVPTMTACASGLILFNLYNEDPSKVNITLYAINEGIDQSIPSPATTSAIVQSSRPASSVVASTQIAIASSPLPTSAIQSLSSARPIATSAVGAIQPARRDPERRTILDLNITLVTQGANHGWSFNPVRLPEGRYYISGLINDGRQTTNKSNVFSVVENEDTSCLSAFESLSASATASRTGAAGGGMTGKTTATATASDGALGGGSESATEGTEKKGLNGGAVGGIVIGILGGLAILALLLFCCRRRRGYSHSREHGSEEGGFMGTGIRHQSHHQKMPSENTTPSDQGHQGVSRIKEPIAMLPVSLRTEESHRSDKTDEKGESSNSINEDGIESLPNTFLPTPISAAYTTSSTRLSSEDNHNVNEFGKGQSESNGIDPFITPTLSEIPIMSPIYANEEIRQLGHSSIQTPQPVILANVKRSSAEENVKPAIGLGIGGTTLKSSNSLMTQQSRSDPGKKRTSLNSLGVRSPTQISPDPNSFGIPDNRNDDKKSGMGLGRSTSSRRKPVPSLGPELRTELARQNSLKDLKGNKTNENDNVEESGRRRSYKLMPDPPIIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HVF2</accession>
    <name>A0A1B9HVF2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_07017</name>
        <name evidence="4" type="ORF">I206_101892</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
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                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
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                <person name="Young S.K."/>
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                <person name="Chapman S.B."/>
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                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
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                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
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                <person name="Zeng Q."/>
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                <person name="David-Palma M."/>
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                <person name="Bowers K."/>
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                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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                <person name="Heitman J."/>
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    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Berlin A.M."/>
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                <person name="Dewar J."/>
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                <person name="Nusbaum C."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
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                <person name="Springer D."/>
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                <person name="Young S.K."/>
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                <person name="Gargeya S."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
                <person name="Sun S."/>
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                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
                <person name="Sun S."/>
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                <person name="Dromer F."/>
                <person name="Young S.K."/>
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                <person name="Gargeya S."/>
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                <person name="Alvarado L."/>
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                <person name="Chapman S.B."/>
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                <person name="Heitman J."/>
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                <person name="Sun S."/>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="554"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="231"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="319"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="239"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="319"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCF47600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC67614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="577" mass="63395" checksum="73653093DCEE2B02" modified="2016-11-02" version="1">MGLDDTVPIKVLLVTVFESVVQVFILCLAGYTLSRVGVTDKATQRKLNVINVSLFTPALLFSKVAYSLTPAKLKEMWIIPLGFVVVTGLSAGVAWALAKLFKLKKSQTAYAMCAAMFQNSNSLPIALIQSLVIEVPGLKWDEHDTKDQMLGRALTYLVLYSTLGMMLRWSWGVKLLSQADDEAVEIDSSNPQHLQPILNDHAVQSPEPLVPHPGARETDPFFTSAEDISRDEHDERLNPSGQFPNQSPNSPSLPFTAGSAHSMHPPMVKRGSTAGYSVMSRRSSSLSRHRKKLNRTESGREFWGLPEQPKMHHIALIEEDSSESEPEDEEWGTLTPGSLRRRQTEPPKSAFQSLLYKAKHRSKTIMKAINDFMTVPMYAALLSIFIAMIPPLQAQMARIKPLEQAIKSAGQCSIPVTLVVLGAFFYSPPEVKPGSGTIHIPSKKEQNNGGLLGYFKSRFQNDHSSGKSKSSAYPGENKTVFVAVISRMVIVPLLMLPVIALLAKFDPFEAAEDPVFILSAILLVSSPPALTLAQITQAASGDAFERLISKTISWSYAVLTPPLTLVYVVIGLIFGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HWR1</accession>
    <name>A0A1B9HWR1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nucleolar protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_06623</name>
        <name evidence="10" type="ORF">I206_101407</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008936.1">
        <property type="nucleotide sequence ID" value="XM_019158323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HWR1"/>
    <dbReference type="STRING" id="1296096.A0A1B9HWR1"/>
    <dbReference type="GeneID" id="30174992"/>
    <dbReference type="KEGG" id="kpin:30174992"/>
    <dbReference type="OrthoDB" id="267048at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12676">
        <property type="entry name" value="RRM3_Nop4p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000406">
        <property type="entry name" value="Related to Nucleolar protein NOP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034808">
        <property type="entry name" value="Nop4p_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="25"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="239"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="421"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="341"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="813"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="734"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="366"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="813"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="862"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="875"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="903"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="921"/>
            <end position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCF47717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC67499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="931" mass="102454" checksum="9AC8BAB06D345A5D" modified="2016-11-02" version="1">MAEEDFISLTGGSSSKKERKERVNTTVFVSSLPYTATTTDLLTHFSYLGPVRHGFVATDKDTGKSKGVGYVTYSLKEDADRAVAELNGSSFGGGNRKIRVSVAGERASLKDRKALANDPESRPKPRIAAGEDKPTGDPNAIRTLVLSGLPEGITKNVLWKKVRKVDDKAELVYPVPAEEGETESSDLANIIFPSHGQALKALPKLHGHTYKGALLSCVLKKRLEKLSARGEGKNQSHAGRLIIRNLAWDTTVQDLRAAFLPYGPIHSIDLPTLPSKLPPSSDPSKPPPPPRARGFAFVWFLTRKDAEKAIEGVNGKVLKTKSGKEGREVAVDFALSKEKWEEANKKPDSEEKSEESGSESGSGEESGSDEGSDDAEESGSDSEDDGEEDGEEDVDMSEAGSEGEEEEEPVKPTLPSVDVGSTLFIRNLPFEVTEQELNTLFRTFGPLRYARITIDKMTGRSRGTGFVCFWNTEHADEAILEAEKVARETGANAMPLGGGAKNPFALPSVLTADPSSSLASRLVLHGRTLEVSRAVTREQAGLMKEDSERARNAGDKRNTYLMREGVIFPNSPAASSLPEAEVEKRQASFNARKTLLRSNPSLYISKTRLSIRQLPLFATDRTLKRLAIYAVREFDAEVAKEEREGLARTEEMDETLSAALEARKSSKKKGKERETAVIQSKIVRQTEKVDPLTALGRSKGYGFLEMKSHKDALKVLRFANNNIAVGGLMWTWWKEELKDLKDRVETQLKGLKDGKTAAGENAEELENRLKRIIQRLGEGDDRSEGGMRGGKTLLIEFSIENVQVVRRRVEKITSHREDSREEGKERNRNGKREFGVGEKRKSGVIAAQDSDDDDDKGSSNNKNKKPKFDKKRRGERGGKDKRAKKEDARSNPPSIPIVQPSAESEKKGIEKLGGHLGSLIGRKRKQRSGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HWU2</accession>
    <name>A0A1B9HWU2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">diacylglycerol cholinephosphotransferase</fullName>
            <ecNumber evidence="9">2.7.8.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I206_06652</name>
        <name evidence="14" type="ORF">I206_101378</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>CDP-N,N-dimethylethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + CMP + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="ChEBI" id="CHEBI:65117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:33776"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
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    <comment type="similarity">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
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        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
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        <property type="entry name" value="CHOPT"/>
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        <property type="entry name" value="BB IN A BOXCAR, ISOFORM C"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
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    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
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            <end position="67"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="12">
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    <feature type="transmembrane region" description="Helical" evidence="12">
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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            <dbReference type="EMBL" id="OCF47746.1"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HX07</accession>
    <name>A0A1B9HX07_9TREE</name>
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        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_05665</name>
        <name evidence="11" type="ORF">I206_107339</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ThrE exporter (TC 2.A.79) family.</text>
    </comment>
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        <property type="protein sequence ID" value="OCF47806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="WWC73372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="kpin:30174034"/>
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        <property type="component" value="Chromosome 11"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="ThrE-like_N"/>
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        <property type="entry name" value="ThrE/Ser_Exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024528">
        <property type="entry name" value="ThrE_2"/>
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    <dbReference type="PANTHER" id="PTHR31082">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082:SF4">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ThrE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="647"/>
            <end position="668"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="705"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="737"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="834"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="860"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="883"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="914"/>
            <end position="933"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="953"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/serine exporter-like N-terminal" evidence="8">
        <location>
            <begin position="518"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/Serine exporter ThrE" evidence="9">
        <location>
            <begin position="837"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="358"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="454"/>
            <end position="501"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="83"/>
            <end position="97"/>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
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                <person name="Gujja S."/>
                <person name="Hansen M."/>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
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                <person name="Zeng Q."/>
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                <person name="David-Palma M."/>
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                <person name="Bowers K."/>
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                <person name="Mohammad A.W."/>
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                <person name="Yurkov A.M."/>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="Chen Y."/>
                <person name="Sun S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </evidence>
    <sequence length="444" mass="50425" checksum="C223E6B16F5FD5DB" modified="2016-11-02" version="1">MTFRSRSGGPIKNRKPKKQTHTRKLHHPSSSKKDENEEEKQQSDIPSWSIPLSSCLESAQIYNPPDSEILSILNRSLHDTLSSDEFIPTIQKIKGLLYDKKWLEVFCGSEFILESYAGRWVPSRACCFREVMDKLVGNIFTGEEKGLEDSMAQLDVDDDESEEDDEEGEDQKEGEDETDEERDDEDSQGDSAEGDDEEGVADSQWRDQAKQLEQTTPCPQETHHILSLGGGAGSELLAITALIRSTILTRPHSHPKFSWTGIDIGNWYGVLEKIENAVRIDWKIDSNLLDINYIKGDLLSLPINAGDSTLKVNNQSDTFIDLPKLLIDKPPKLITLFFTLTELLTQSRPRTLSILDTITQNTSSGTYFLVIDSASDISDFSLGKDGRKYPVYMIIDTLLTAKGRGWEKVRAEDSRWFRFSEGVGAGWKVKLENTRYWYRLYRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HXG4</accession>
    <name>A0A1B9HXG4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G patch domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_05806</name>
        <name evidence="4" type="ORF">I206_107477</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894014">
        <property type="protein sequence ID" value="OCF47941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009160.1">
        <property type="nucleotide sequence ID" value="XM_019157520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HXG4"/>
    <dbReference type="STRING" id="1296096.A0A1B9HXG4"/>
    <dbReference type="GeneID" id="30174175"/>
    <dbReference type="KEGG" id="kpin:30174175"/>
    <dbReference type="OrthoDB" id="20507at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011666">
        <property type="entry name" value="DUF1604"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384:SF19">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07713">
        <property type="entry name" value="DUF1604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26093">
        <property type="entry name" value="HTH_TGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="156"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="708"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="711"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="734"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="768"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="778"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="827"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF47941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC73506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="860" mass="96380" checksum="1D61C7A918765AC7" modified="2016-11-02" version="1">MTSRLKHKLELENVNLNGAYLNESFVQIGTPLPALSEHKKDKQEYVPEWQQEVRDEQGRRRFHGAFTGGFSAGYYNSVGSKEGWTPSTFKSSRSNRANKVQRAEDFMDEEDLQHLKDDRQLENTSTFKNDGFGATKEELGGKSLPSAIETLIAPSSSSIGEKLLQKLGWRPGQGIGPRVTLRKLKLQQGKLGGSRVGMTQEVDEEDEEGSKHTYAPRDAELLTFESKEDKQGLGFVKGRGMGSLPGKRPTMGSRRPDDIEDDPYVEAGPSSRHLAFDSMDDEDEIIMMGGSRPGLGSRSNKENRFDGPQDTWHDGRPVLAGFSLDPKGVPPDTWFVMPEIPPDWRPRPARVWGTTKKWDQKPGEEELKKEVIRGEPGRPLTFEQRGAALGEEQRLSKAKSIFDYMSTKDRERLASLAAAAPPPPPGSLSLQPPPEEAQILPATEVDIPPLSPRTASAALKGFIPYGDDLERQNRYISYLKSQTHNTENPNPTLKRGTIEEINKELIDFSSSARIFKPMSYAMSNRFTTGSNSLAASDLKQAKPGLHIFDLEKAKAEQEEAEKLKTTRTVEVEEVKRILAPREEAAKNGMYGKMTRETKNWYPSKLICRRWGVKDPHPQGDPNQGKESNTNTAVIETMPLPTNDASWESKFIHKPITSEKVSNSTSPQANDELEKQPTNINEVGMANDINQGRDTLTYKKPSIDIFKAIFASDDEDEDDDEDEENTETQKPVITTKEDSEKYEDPFPVPIKGEEEGPVDLNTFKPVFSIRKEDSEENMKKKKKDKTKKRKGVLSFDVGDEGEDQVEIKEDRKKKKKKDKSNSNGNDNALEEAEAQNDDGEWVEKPNVVPRLVGRKGAADFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HXM7</accession>
    <name>A0A1B9HXM7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_05902</name>
        <name evidence="2" type="ORF">I206_107569</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894014">
        <property type="protein sequence ID" value="OCF48035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009254.1">
        <property type="nucleotide sequence ID" value="XM_019157614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HXM7"/>
    <dbReference type="GeneID" id="30174271"/>
    <dbReference type="KEGG" id="kpin:30174271"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCF48035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC73597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="203" mass="23678" checksum="53E2E12E8A436D17" modified="2016-11-02" version="1">MSCYPYISIPFPTFLICFSYPKPKAQVPCLAELRKKAEFLSSSSSKITNTNYSQREIKFPEKVTSKGLPIPISIPKFTFTSYSTHTFQSSNSCHLLSFDMIPRKEDEEDKVKESINSDDIEYGFDQIYRLGKKPNKLYKLNSNEGYDIIKYDLQKDITEIQLTPKINSFSIKSNYYKRDIQYNEAKNEIRHDSTDPDLSWPSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HYC2</accession>
    <name>A0A1B9HYC2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NADPH:adrenodoxin oxidoreductase, mitochondrial</fullName>
            <ecNumber evidence="8">1.18.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_06132</name>
        <name evidence="13" type="ORF">I206_107799</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Agaricomycotina</taxon>
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            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Murphy C."/>
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                <person name="Roberts A."/>
                <person name="Saif S."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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                <person name="Birren B."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
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                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
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                <person name="Springer D."/>
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                <person name="Gujja S."/>
                <person name="Hansen M."/>
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                <person name="Imamovic A."/>
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                <person name="Sykes S."/>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="Young S.K."/>
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                <person name="Gargeya S."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
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</entry>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </source>
    </reference>
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            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        </source>
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    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">CBS 10737</strain>
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    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
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        <text evidence="2">Protein modification; protein glycosylation.</text>
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            <topology evidence="1 10">Multi-pass membrane protein</topology>
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    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <dbReference type="EMBL" id="WWC72937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="688" mass="77631" checksum="6295F2D820B0A38A" modified="2016-11-02" version="1">MATIPGTENVRFRRPTAGPNAVKPTEPKKDEFGSMAPTGFKKRHQGLLQDQVGRNKAGPLVPGLSFAFRLLLLVRAVAAMYSVISDCDEVFNFFEPLHYFQYNSGFQTWELSPEFAIRSWSYVLLHWPLAHAIPKVLSVGKRPAFFALRLSLGAICSFCEAKFFRTVVETINERVGRYLLFGFMLSAGMWTASVAFLPSSFCMYTTMIASSYWFHPATSTPTGIKRAYFATFAFAVGAIVGWPFSAALAIPFVLEELFLTGGEIILPAQRGSWISKRWETMGKAVGLAAGIAIPVSMIDSWAYGRSTFPTLNIITYNLFSGKGPDLYGTSPTSFYFANLFLNFNFLLPLALIALPALAITNKFDYRRLGKTQMKPKEGETSPYTLLAIRLSPFYLWLAILSAQAHKEERFMFPAYPFLLFNAAVSIYLIRGWIESYYIHITNSPYNASRSSIFSIFTLLAVLVPGVISFFRVGGSIYFYHAPFDIVHHFQYKSIPSFLSGLGYEPVPLPADFKPYGNEVPTPQWDMTPLQNLEKPLTLCYGTEWYRYPSSYLVPEGVRVRWVKSEFDGMMPRPWEPSSENSTSAWPRDETRRARAGRFNGDNKESGDVGTYVDASECTYLVSLSLPSTAHTTLEPDWASKSEWEEEYCKGFLDAANTKWWARLIWLPGGLLEKGRVWGDYCLLKRKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I058</accession>
    <name>A0A1B9I058_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_04599</name>
        <name evidence="5" type="ORF">I206_105779</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF48912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC71820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010131.1">
        <property type="nucleotide sequence ID" value="XM_019156329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I058"/>
    <dbReference type="STRING" id="1296096.A0A1B9I058"/>
    <dbReference type="GeneID" id="30172968"/>
    <dbReference type="KEGG" id="kpin:30172968"/>
    <dbReference type="OrthoDB" id="2559954at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="30"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF48912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC71820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="289" mass="32859" checksum="A087A326D5B41F0E" modified="2016-11-02" version="1">MSSTPPLKYVKINGADLAYKEAGDACNQLFITLHGGRGLGSHESDFEAYRPLSDKYHIISFDFRGHGQSSFTPPYTFKQIVNDIETIRIHFNTIYNKIEKKLVICGGSFGGFLAQQYAINYNDNLTHLILRGTAPSYEHEEEAFQVLEQRLNKAPLASINMLKKVFSNFKDDDEMRLIMFAIGPLYSEIEYNPDKGLEVSRLRKLSAKVHNDLYSEEEKYFDYRPKLNQIKSKTLIIVGDKDWICPPSQSKLIHEGIPGSQLLIVPDANHSVHSEKNQEVIAAIREFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I083</accession>
    <name>A0A1B9I083_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_04636</name>
        <name evidence="4" type="ORF">I206_105816</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF48949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC71857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010168.1">
        <property type="nucleotide sequence ID" value="XM_019156366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I083"/>
    <dbReference type="GeneID" id="30173005"/>
    <dbReference type="KEGG" id="kpin:30173005"/>
    <dbReference type="OrthoDB" id="2564982at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF48949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC71857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="233" mass="26802" checksum="6777AC1A6AD2462E" modified="2016-11-02" version="1">MAPYIRLPRQNNSTNTNPGTSGDSTSNDASSFMDKYSKEIYISLAVLGVLILSYFLWAGSTNRLFYPPFNQKRCNECKKGISKEKKEEEDYFKSSADAENSKGWICKSCQEKLEEKMLNDELEKEEEKGKKIKSKSKFHIKEKSKIKSKKNIEDISEDELDSSDEEEEEVVIETVKKVKKVERDLPKIEKRKSRPPPLKKRYEEESDSDDYDSSDEEDVRGKAGGKVKVRSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I0C5</accession>
    <name>A0A1B9I0C5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
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                <person name="Hansen M."/>
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                <person name="Imamovic A."/>
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            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
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                <person name="Birren B."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
                <person name="Sun S."/>
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                <person name="Young S.K."/>
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                <person name="Gargeya S."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
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                <person name="Young S.K."/>
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                <person name="Gargeya S."/>
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                <person name="Berlin A.M."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
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                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
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                <person name="Imamovic A."/>
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                <person name="Pearson M."/>
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                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYG1 (TC 2.A.94) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="WWC72020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019156532.1"/>
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        <property type="component" value="Chromosome 8"/>
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    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016036">
        <property type="term" value="P:cellular response to phosphate starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="SPX_SYG1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EXS_C"/>
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        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783:SF103">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 53 MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="568"/>
            <end position="588"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="608"/>
            <end position="631"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="652"/>
            <end position="674"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="686"/>
            <end position="703"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="833"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="876"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="9">
        <location>
            <begin position="1"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="EXS" evidence="8">
        <location>
            <begin position="765"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="34"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="400"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1000"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="143"/>
            <end position="162"/>
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        <location>
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            <end position="221"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
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        <location>
            <begin position="1000"/>
            <end position="1010"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
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            <end position="1044"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1046"/>
            <end position="1056"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
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            <dbReference type="PROSITE" id="PS51380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF49115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC72020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1056" mass="120395" checksum="137B836B57B6E659" modified="2016-11-02" version="1">MKFGRYLAENQTPEWKRAYIDYRQCKKKIKVVAARLGQVKERKEGQINGGEEEDDGDSSGADDDHGPSALPTNRKATPDTIRGSLRSRMGSNAATPRLERWTSRATDRTQRYGSTGVSPRPPHSSISERAPPPLDLGSPSVDNPENFPSGPSPNPSNTLNTPRLDSSSRSKRGVVFSPNLKADAIVETSIEEESQHSRPSSGESDTHLNKPSRDDIRRGEGLKSVPSPNYDAKSPRPGSGSGPGPMGDTHRMTSAPSNPDTPKGGKSPRLGPRSLRSMTLPSPALPFRSPGGAVKTADSIDELYKQLEPDEKDFFDFLEHELDKVETFYLARENDAMKRSHDLRDQLKELAEHRKIYHELYPHGVPEWETKVGRILPQAQAVVGVQTVNKLRQRLGFQDHDLSPHQNANTESNKPDHLQVDSNVASHERSSSPMMMDEHTRSSLREAMAADKDHQTYNPERYQKYKKELKTAVLEFYRQLELIKNYRIMNLTGFRKALKKFEKTSKITCLEMYTDEKISKATFSQSQAIDGLIKQIEDLYTSHFEHGDSKRARDKLRRQTTERTHYNSVFRSGVMIGIGLPAAVFALIESSKSHTREQIPAWGGMLQVYGGLYLPIMFAMLFQLNLGAYVAARINYEFVMELTRPTIDYRSFLEIPAFLFLTLSYCFYFTFAQIGSANVAPTTWPAAWLVLVVVFFLNPLPVLRRGTRYWLLKVLFRVCTPGYSRVEFIAFFLADELNSLVYSMQNIYFISCGYSKKWPGDVFTVCHSAKTWPYALLACLPAGSRFIQCLKRYHDSKLNIHLINAGKYLSVILQQSLFVYWRSRNSVIDDRAFIVWTIVAIVSSAYTSTWDLVIDWSLFRPQAGLLRKDLGYSQRYVYYLAMFTNVLIRFVFIWYIPLSTSNVRLRSFMFALAEMLRRWQWNFFRVETEHLGNADAYRVTREIPLPYRRINNDSDEEGDGEMEEHKSIYNKEKYKKKNMLSYQLDKLKLRHNIKIKNKNDLTPISVSSPSNEEEGGEGRGPDALNVGPRGHEPQREYEASRPGDYDNTTPRGNQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I0T1</accession>
    <name>A0A1B9I0T1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA ligase</fullName>
            <ecNumber evidence="14">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">I206_04811</name>
        <name evidence="19" type="ORF">I206_105988</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="14"/>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC72029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019156541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I0T1"/>
    <dbReference type="STRING" id="1296096.A0A1B9I0T1"/>
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    <dbReference type="KEGG" id="kpin:30173180"/>
    <dbReference type="OrthoDB" id="206088at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903461">
        <property type="term" value="P:Okazaki fragment processing involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07900">
        <property type="entry name" value="Adenylation_DNA_ligase_I_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="OBF_DNA_ligase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="2.40.50.140:FF:000062">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DNA ligase"/>
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    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
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        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
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        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
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    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
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    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
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    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
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        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
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        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
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    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
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    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF4">
        <property type="entry name" value="DNA LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
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    <dbReference type="Pfam" id="PF01068">
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    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00333">
        <property type="entry name" value="DNA_LIGASE_A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 14 18" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="17">
        <location>
            <begin position="550"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
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            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
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            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="146"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OCF49124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="WWC72029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="819" mass="90578" checksum="5658D6889F8489D5" modified="2016-11-02" version="1">MSEQDTKPNIIKKKKRVVQSDDEEDDLPINGASSSKVITTPQSEAPIKKDSSPPHKKPKTSPAPEKIASIFAPPPKKVEKPKSSNDPSKSTIKEVKEEKPKINGKESKSVASIFAKPAKASSSKVKVEDDVKEEEEEGRGSPTRDDEGEEELEDEEEEDEQEEKAAVKLASIFTKNHKAVPVADKGWKDGEPVPYAALVSTFEKIEATTKRLEILELLTQFFLVVARRDAAKQAKDSNLLKVVYLCINRLCPDYMGIELGIGETLLIKAIAESTGRATTKIKEDLRKEGDLGKVAMNSRNTQPTMFKPKALTVPYVFQNLTDIAKSIGNASQAKKVGIIKKLLAACQGNEAKFIVRSLEGKLRIGLADKTLVVALAHAIVLKGMSEKKIPHDLLAAKLEEGAEIVKSVYSELPNYDLVIPALLEGGVEGLKARCRLTPGVPLKPMLAKPTKAIGEVLDRFEGKEFTCEYKYDGERAQVHLLEDGSIAVFSRNSENMSAKYPDLVEQVPRAIKPSVKSFVIDAEAVAFDLETKKILPFQDLSRRKRKDVKTEDITVRVHLFAFDLLYLNGESLLTKEFKERRAMLQEHFQPVESEFAFAKSSDSKSTEEIGAFLEESVKDGCEGLMVKMLASSNSTYEPSRRSMNWLKLKKDYLSGVGDSLDLVVIGAYYGKGKRTNVYGAFLLACYDQDSENYQTICKIGTGFSEDFLLESYNLLKPLEIEVPRGDMEIGSAKPDVWFEPKIVWEVLTADLSLSPVYAAAHGLIDSRGISLRFPRFIKIRDDKSADEATSAEQVSEFYQRQVTAGGGKKGGGGGDDDFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I1E0</accession>
    <name>A0A1B9I1E0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_05053</name>
        <name evidence="3" type="ORF">I206_106227</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010579.1">
        <property type="nucleotide sequence ID" value="XM_019156777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I1E0"/>
    <dbReference type="STRING" id="1296096.A0A1B9I1E0"/>
    <dbReference type="GeneID" id="30173422"/>
    <dbReference type="KEGG" id="kpin:30173422"/>
    <dbReference type="OrthoDB" id="2573341at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF49360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC72265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="617" mass="67163" checksum="7B572E0E64BCBCE5" modified="2016-11-02" version="1">MSPHVQPLFTSSPLIFPPASSTPVPGQSLFVTSPISATPPLDETVELKHAGSSQPSSRYNSIPPSPVFETLSFSKVPIPSSTTASTDSEAFSSDWAGPSESKRSSIQSPSLISCLFQSTSIVAKDTVNGNRKCSFNQGRSSSGEGGNKPILRRDTASMSISTSASEDNFSSNGFGLGINKLNLEENDDRKAPALRKRPSILTFAVSSPRAGPSRPPSRSASTSCSPTSSYACTRLPRSPCVRPNWGKIRGQVEKEIKEDDDEDKDQDDDDEEDEEEDYMIDSPLPIPGQESDEEDQGYVEDDEEDGFTSDEDDNAINHGADRIFANSTVGDKAGPSGWNSIEWNKDYLATPKRRSNIIPSQPNYMTSTDDCFDQPIMRGRKTSIAINENTKPSSNRCTRHRSPPPPIKLKSSSIQVPPAARSPSAFDLCRRRGSGSVEVTTTTKKGWKSDDYGFLPNTASTSQKVLEKTNSFKLPSASTKTTTSNEPLQVQTQTQIQGGIRKNSLPTPKLDCRSSSTRSILKRNATSSNIHEPQSTPMIRSSGEIAKIPPKTPPLDNHTIPLNGVNLLRRGSAPTKSINKQNKANILEIAKPCLARSATGYEEEEMGYHKDRGLRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I1V7</accession>
    <name>A0A1B9I1V7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Calcium uniporter protein, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">I206_04040</name>
        <name evidence="22" type="ORF">I206_104379</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="22" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Highly selective calcium channel localized to the inner mitochondrial membrane, which mediates calcium uptake into the mitochondrial matrix. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates ATP production, cytoplasmic calcium signals and activation of cell death pathways. Sufficient to operate as a pore-forming channel without the need of calcium-sensor or auxiliary subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotetramer, assembles in a dimer or dimers configuration with two interfaces.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCU (TC 1.A.77) family.</text>
    </comment>
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        <property type="protein sequence ID" value="OCF49519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC70428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010738.1">
        <property type="nucleotide sequence ID" value="XM_019155780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I1V7"/>
    <dbReference type="STRING" id="1296096.A0A1B9I1V7"/>
    <dbReference type="GeneID" id="30172409"/>
    <dbReference type="KEGG" id="kpin:30172409"/>
    <dbReference type="OrthoDB" id="278338at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990246">
        <property type="term" value="C:uniplex complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0015292">
        <property type="term" value="F:uniporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036444">
        <property type="term" value="P:calcium import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MCU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039055">
        <property type="entry name" value="MCU_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462:SF10">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04678">
        <property type="entry name" value="MCU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium uniporter protein C-terminal" evidence="20">
        <location>
            <begin position="280"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
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            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
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            <begin position="480"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
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            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
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    </feature>
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            <end position="530"/>
        </location>
    </feature>
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        <location>
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            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005653"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022837"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
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        <source>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04678"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF49519.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC70428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I2R9</accession>
    <name>A0A1B9I2R9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Type 1 phosphatases regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_04356</name>
        <name evidence="5" type="ORF">I206_104068</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the YPI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011048.1">
        <property type="nucleotide sequence ID" value="XM_019156090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I2R9"/>
    <dbReference type="STRING" id="1296096.A0A1B9I2R9"/>
    <dbReference type="GeneID" id="30172725"/>
    <dbReference type="KEGG" id="kpin:30172725"/>
    <dbReference type="OrthoDB" id="307488at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011107">
        <property type="entry name" value="PPI_Ypi1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07491">
        <property type="entry name" value="PPI_Ypi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF49829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC70121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="172" mass="18640" checksum="A28719644E20F3EA" modified="2016-11-02" version="1">MSNQARQQGATLRGTAQTEIEAGPSTSPPEQPPAGVLKLRGGPLKKQRVVWTDETVDNEGMGKKKSKICCIYHKPKAFDESSDESSCSSSDEEHTHDSSKSNGRSNTHKHKHRVREGGNDELGESDSQSSESDGGAGDGRARPAIKPRKHKHSHNCDSTGGRVNKYDVQPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I2W9</accession>
    <name>A0A1B9I2W9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Actin-related protein 2/3 complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_04431</name>
        <name evidence="9" type="ORF">I206_103995</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as a component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ARPC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011119.1">
        <property type="nucleotide sequence ID" value="XM_019156161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I2W9"/>
    <dbReference type="STRING" id="1296096.A0A1B9I2W9"/>
    <dbReference type="GeneID" id="30172800"/>
    <dbReference type="KEGG" id="kpin:30172800"/>
    <dbReference type="OrthoDB" id="429520at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.190:FF:000003">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.190">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006789">
        <property type="entry name" value="ARPC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036743">
        <property type="entry name" value="ARPC5_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12644">
        <property type="entry name" value="ARP2/3 COMPLEX 16 KD SUBUNIT P16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04699">
        <property type="entry name" value="P16-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039096">
        <property type="entry name" value="p16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69103">
        <property type="entry name" value="Arp2/3 complex 16 kDa subunit ARPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00060329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF49900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC70051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="158" mass="17077" checksum="C576A8BF4B725C3E" modified="2016-11-02" version="1">MAEYAFRKINIDALEEDVLLPSDLYDPDPRGPDGVLSDAQAKSTEVRNLISRGDIPGALNAILTDPPYGEGVDEAKNLTKNALLLILNSTRASEIPAILKSLGQEQQDHLMAYIYKGMAAIGQGSDVTGSVLLNWHSQLTEVAGVGCIVRVMTDRRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I2X7</accession>
    <name>A0A1B9I2X7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAD2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Outer kinetochore protein DAD2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">I206_04426</name>
        <name evidence="20" type="ORF">I206_104000</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="20" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011115.1">
        <property type="nucleotide sequence ID" value="XM_019156157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I2X7"/>
    <dbReference type="GeneID" id="30172795"/>
    <dbReference type="KEGG" id="kpin:30172795"/>
    <dbReference type="OrthoDB" id="3230169at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013963">
        <property type="entry name" value="DASH_Dad2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28036">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28036:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08654">
        <property type="entry name" value="DASH_Dad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="80"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00030568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OCF49896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="WWC70055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="124" mass="13628" checksum="96540A6645083CE7" modified="2016-11-02" version="1">MSTARPVQPNLPPSLQILYQKQQEYAGLQALREASSELVGRVEKLAEMSNIMADGGEAVGGVLRNWPHVFSILNLFAQQQSETSQTNIPEEEQDEQEPLPVLVRLPYGGETSTTTSKEGSETTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I4R1</accession>
    <name>A0A1B9I4R1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Arginase</fullName>
            <ecNumber evidence="2 11">3.5.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I206_03818</name>
        <name evidence="14" type="ORF">I206_105273</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-arginine + H2O = urea + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:20569"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="EC" id="3.5.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8 11">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.1" evidence="2 11"/>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011713.1">
        <property type="nucleotide sequence ID" value="XM_019155559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I4R1"/>
    <dbReference type="STRING" id="1296096.A0A1B9I4R1"/>
    <dbReference type="GeneID" id="30172187"/>
    <dbReference type="KEGG" id="kpin:30172187"/>
    <dbReference type="OrthoDB" id="9992747at2759"/>
    <dbReference type="UniPathway" id="UPA00158">
        <property type="reaction ID" value="UER00270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004053">
        <property type="term" value="F:arginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006525">
        <property type="term" value="P:arginine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09989">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000009">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014033">
        <property type="entry name" value="Arginase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01229">
        <property type="entry name" value="rocF_arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782:SF3">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0056">Arginine metabolism</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR036979-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCF50494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WWC71319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="383" mass="41201" checksum="3C152C69D3A5732A" modified="2016-11-02" version="1">MSFVPRLSSSMRSSLPASSIRRITSIRNYHIYSKPSAEKGLTEPQYKYKFLEGNPTVGIVGCPFSGGQGRTGVDLAPNKLISAGLVDQLTSLGWEVHYNSQEQKYIDIPFNPISTSSSSSSSSSSSASSEVKIQKLPDEDIGKMKKPRLVSAVNEKVSKEVEEIAKKGWLPLTLGGDHSLAMGTVSGTKAKYPDACLIWVDAHADINTPLSTDSGNLHGCPVSFLLGLEGTDVAPFNEWLKPCLKPEEIVYIGLRDIDGPEKAILKKHGIKAFSMHHVDKYGIGKVVEMALDHVNPDRSKPIHLSYDVDALDPIVAPSTGTPVRGGLSFREGHYITEALAETGCLVSVDIMEVNPSLLDPNSVEKTVAAGCSLARASLGETLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I502</accession>
    <name>A0A1B9I502_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-galactopyranose mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_03930</name>
        <name evidence="3" type="ORF">I206_105160</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011824.1">
        <property type="nucleotide sequence ID" value="XM_019155670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I502"/>
    <dbReference type="STRING" id="1296096.A0A1B9I502"/>
    <dbReference type="GeneID" id="30172299"/>
    <dbReference type="KEGG" id="kpin:30172299"/>
    <dbReference type="OrthoDB" id="38045at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000220">
        <property type="entry name" value="UDP-galactopyranose mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734:SF4">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734">
        <property type="entry name" value="PHYTOENE DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF50605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC71207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="536" mass="59439" checksum="1B5D1867B5F43361" modified="2016-11-02" version="1">MSITATSSSASVVNDSPYTGSAANSDTSNEDEFTEIETLVIGAGPTGLGAATRLHQLGRSFIIADSAEAPGGLASTDITPQGFYFDVGGHVIFSHYAYFDDALHRALPNEEDWSTHQRVSYVRSAGNWVPYPYQNNVSQLPLDLRVKCVDGLLAAAEHRAQTAGQKPKNFDEWIVRNMGEGIADLFMRPYNFKVWGTPTYKMQCKWLGERVAAPNVRTVVKNALTMQTAGNWGPNATFKFPMKDGTGGIWTAVADKLPNERFRLGKSGEVRLVDGASKVVEFGDGRKVKYNNLVSTMALDGLLDLLDGGANEKVSVDRMKVAAKEGLVYSTTIVLGIGIRGQRPDRIGDKCWLYFPEDNAPFYRATIFSNYSPYNCPQADIKLPTLQKADPSLDYEKEPKEGPYWSLMLEVCQSSEKPVDLDTLMEETIRGAIATELMLPADEIVSLYERRFDHGYPTPSLGRDGALAQILPPLRDEFNIRSRGRFGSWKYECGNQDHSFMLGVEAVDNALFGTPEMTLHETDWVNGRRNIERRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I5R3</accession>
    <name>A0A1B9I5R3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">T-complex protein 1 subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_02916</name>
        <name evidence="12" type="ORF">I206_102566</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF50859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012078.1">
        <property type="nucleotide sequence ID" value="XM_019154675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I5R3"/>
    <dbReference type="STRING" id="1296096.A0A1B9I5R3"/>
    <dbReference type="GeneID" id="30171285"/>
    <dbReference type="KEGG" id="kpin:30171285"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03335">
        <property type="entry name" value="TCP1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000009">
        <property type="entry name" value="T-complex protein 1 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000070">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012715">
        <property type="entry name" value="Chap_CCT_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02340">
        <property type="entry name" value="chap_CCT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCF50859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC68635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="558" mass="60145" checksum="D25A68E256706F3A" modified="2016-11-02" version="1">MASTMYQRDPRAGLFLGGTRSSGAEVRDANVTACQTVSNILKSSLGPVGLDKMLVDNVGDVTITNDGATILSLLEVTHPAARILVSLATQQDKEVGDGTTSVVLLASELLRRANELVRNKIHPTTVITGYRLACKEACRFMAEQLSTKVDKLGKDSLINVARTSMSSKILAADDDFFAPLAVEAMLAVKTINAKGEKKYPVKAVNVLKAHGKSARESFMVKGYALNCTVASHAMKTRITNAKIACLDMNLAKQRMHLGVHITIDDPEQLEAIRARESEITLERVRKILAAGANVVLTTKGIDDLCLKEFVEAGAMAVRRCRKEDLRRIAKATGATMISSLANLEGDETFEATSLGSAEEVSQERISDDELILVKGTKVVNSSSIVLRGANDYMLDEMERALHDALSIVKRTLESGSVVPGGGAVETALSIYLENFATTLGSREQLAIAEFANALLTIPKTLALNAAKDSTDLVAKLRAYHNAAQNVALNDPKRGLMFYGLDLINGQIIDNRQAGVLEPTISKIKSLKSALEAATSLLRIDDSIQVAPERREEVDPHGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I5Y4</accession>
    <name>A0A1B9I5Y4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">triacylglycerol lipase</fullName>
            <ecNumber evidence="6">3.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Autophagy-related protein 15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">I206_02995</name>
        <name evidence="23" type="ORF">I206_102642</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="23" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to both phosphatidylinositol (PI) and phosphatidylinositol 3,5-bisphosphate (PIP2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
            <location evidence="3">Multivesicular body membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Prevacuolar compartment membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="6"/>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF50933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012152.1">
        <property type="nucleotide sequence ID" value="XM_019154749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I5Y4"/>
    <dbReference type="STRING" id="1296096.A0A1B9I5Y4"/>
    <dbReference type="GeneID" id="30171364"/>
    <dbReference type="KEGG" id="kpin:30171364"/>
    <dbReference type="OrthoDB" id="58570at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034496">
        <property type="term" value="P:multivesicular body membrane disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046461">
        <property type="term" value="P:neutral lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000129">
        <property type="entry name" value="Autophagy related lipase Atg15, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050805">
        <property type="entry name" value="ATG15_Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175:SF2">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="20" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628363" description="triacylglycerol lipase" evidence="20">
        <location>
            <begin position="24"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="21">
        <location>
            <begin position="251"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="460"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="508"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="474"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="515"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="OCF50933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="WWC68708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="539" mass="58964" checksum="5E2D324AD14515BF" modified="2016-11-02" version="1">MHIPLITNLATSILPLLFSSSSSLDTLESPAITIRPIHAHIHKYNSTSSTLYFHNTSSEASFYARDYPLSTFNADVLSDIPSLGPDDLTIRTIKTTIRRPRVKPPTIFSWIMSHRKVNNGIIPFGLNSSEEIWIAPDMNSDDGDWEDVEVIAPDIKDRQTLITLAKITSNAYVLPDSGEWWPVGKFNNHTVPFGWDDNADGLRGHIFADPKNETVIISMKGTSAGVLGSGGPTAKNDKFNDNLLFSCCCARVDFSWTPVCDCYAGGWRCEQTCLEDALVNESVYATVGTNLYNNVTYMYPNATIWLVGHSLGGSLSALVGLSFGAPAVTFEAPGDKQAASRLHLPLPPGMPAEKTAITHVYHTADPIPNGACNGAYSGCYAAGFALESKCHTGQTILYDTVTVKGWAVDIRTHRITDIIDKVLVDPWPEVDKPKKPSTQPSLFSMNGGWDLGLGGQWWGWGRKGPGKDKVPNDDGGEGEEDDGDWEKHGGVPQAEAEDDCVDCFKWEFGDGWNNDPKKKAQELSIAEARRKNSKRPETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I603</accession>
    <name>A0A1B9I603_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rossman fold oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_03017</name>
        <name evidence="3" type="ORF">I206_102664</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF50955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012174.1">
        <property type="nucleotide sequence ID" value="XM_019154771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I603"/>
    <dbReference type="GeneID" id="30171386"/>
    <dbReference type="KEGG" id="kpin:30171386"/>
    <dbReference type="OrthoDB" id="5296at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF12">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF50955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC68730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="31413" checksum="10A2D8BCC6997BAE" modified="2016-11-02" version="1">MSVAVIQGASGSLGLALARHILQNTGLTVYALTHRPDSKVSDITDRILEGISDDAGKERLTVVDDVDIRNEKGLSKAAKLVEQREGADRIRLIACMAGVLHPEKSLSAIDLSKSIDQFQINTLGHLLTYKHFVPLIPNKRKFECLSTDWKDYQGEDPAQGLISSDSSLCWSMSARVGSISDNNRGGWYSYRASKAATNQIIRTLDHELINKNSSAVAVGYHPGTVITSFTKPVIGNDAVADPSKGKFEIDQAIEKMVGVMGQIKRDESKKWEGKCWDWKGERVEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I6A6</accession>
    <name>A0A1B9I6A6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_03112</name>
        <name evidence="6" type="ORF">I206_102757</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF51047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012266.1">
        <property type="nucleotide sequence ID" value="XM_019154863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I6A6"/>
    <dbReference type="STRING" id="1296096.A0A1B9I6A6"/>
    <dbReference type="GeneID" id="30171481"/>
    <dbReference type="KEGG" id="kpin:30171481"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF1">
        <property type="entry name" value="PEPTIDOGLYCAN-BINDING LYSIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628384" description="LysM domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="24"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="80"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF51047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC68822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="154" mass="17068" checksum="5DC3D255F836A4FE" modified="2016-11-02" version="1">MFVKLALTVLPLLSSVFAIDGCTRNATVVSGDTCDSISRKYGVSTYQLALVNDATIDENCDNLQPGQVVCLGIEEHDCTKVYTVVADDTCDYIQQTYGISNETLWSNNPQIDAACDNIYIGEVLCVDTDSYTYPQYNETLYNALAYTYLPYCDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I6F0</accession>
    <name>A0A1B9I6F0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_03181</name>
        <name evidence="3" type="ORF">I206_102827</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF51115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012334.1">
        <property type="nucleotide sequence ID" value="XM_019154931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I6F0"/>
    <dbReference type="STRING" id="1296096.A0A1B9I6F0"/>
    <dbReference type="GeneID" id="30171550"/>
    <dbReference type="KEGG" id="kpin:30171550"/>
    <dbReference type="OrthoDB" id="2409325at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="586"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF51115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC68891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="615" mass="65374" checksum="3C10932B72EE8A97" modified="2016-11-02" version="1">MSTQPSTSTPTAIPGASLPSSSKPKRNKKKSANKPSVKTPSVVEESPVPIAVATPEEAAPSTNENKEKGPVEEVIAKRQRQLIKKLQRFRGYAAQPHESLNADQRAAVASLPAMEGVYKELDDLIKQIEPVELEQAGRIREVKEQAEQEVQISIAKRISEFQSSLSTPLSLFLRLHQLLHPARSTDHEHLTFARLELPSKLQDEVQATDVLRVGRMYEDLISGGERGSEVIAGLIRGPTGEDEENDHVHHLLTLLTGSDSEQIDKVTPEEIETEDAPTVEVQEPASKASSENSLPNGDVKQEVESVQANGQGALNFLQEDELVEEDIDIPSLAADQTSGSHPPQEPITTVPPPPIDATPAPSDVDTSNPAPTSFAPSTFDWAADEDLDEAEEAAHIRQAFALPPSGAQTPAIAPSQPEAQGKVEEQNVLTEEQEPAIALIQDNELANAHVSESVVNTATGVNSTGVPVPPAVESTAAPTQRQGKAQRGQGRGKGGKNGSGAGRNPQNQKAPVKPSVDEDGFQVVGRQAPQQTNNRGRGNGIQRGRGDGRGRGGQGQGNRGQGGTGGRGGARVSSTSRLTGEGQPGGNKQPKQQQQRQPSHNQTQNKNPAPSPTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I6K9</accession>
    <name>A0A1B9I6K9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber evidence="8">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_03219</name>
        <name evidence="10" type="ORF">I206_102869</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="8"/>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF51153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012372.1">
        <property type="nucleotide sequence ID" value="XM_019154969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I6K9"/>
    <dbReference type="STRING" id="1296096.A0A1B9I6K9"/>
    <dbReference type="GeneID" id="30171588"/>
    <dbReference type="KEGG" id="kpin:30171588"/>
    <dbReference type="OrthoDB" id="16120at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04087">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1150:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016325">
        <property type="entry name" value="Phstyr_phstse_ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0963">Cytoplasm</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCF51153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC68933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="390" mass="43481" checksum="68DAE4158A8F8809" modified="2016-11-02" version="1">MTSDTSASHQPVASTSYLPPRKYILSKAHLAAFQRSRTHKEVVNFIEELNDAVVGKKLTEAGEGSERTKPIMGILDTILDIAKSTPPVDNKLSRFGNPAFKDFYDKVGEASTRLHSRIGGLPAEAIPEIEVYFQESWGNKQRVDYGSGMEFNFLCWLLCLTKLGIFTKDDYEYLVLGLFWRYIEVMRYLQSTYWLEPAGSHGVWGLDDYHFLPFLWGAGQLKDHKHLRPKAIHDPEILDAFGKDYMYLSCISFINSIKTASLRWHSPMLDDISAVKTWAKVNEGMKKMYIAEVLGKLPVMQHALFGSILPFPTPEEDPILKAALEEEGTGEVGQVDEHGHIHVKGEPGWTMDCCGIPVPSAFAAAQDGASPPIGSVAFTARSGIKPIPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I6P0</accession>
    <name>A0A1B9I6P0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Short-chain dehydrogenase/reductase 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Retinal short-chain dehydrogenase/reductase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I206_03254</name>
        <name evidence="16" type="ORF">I206_102904</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF51188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012407.1">
        <property type="nucleotide sequence ID" value="XM_019155004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I6P0"/>
    <dbReference type="STRING" id="1296096.A0A1B9I6P0"/>
    <dbReference type="GeneID" id="30171623"/>
    <dbReference type="KEGG" id="kpin:30171623"/>
    <dbReference type="OrthoDB" id="10253736at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052650">
        <property type="term" value="F:all-trans-retinol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05339">
        <property type="entry name" value="17beta-HSDXI-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000131">
        <property type="entry name" value="Short-chain dehydrogenase/reductase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Ketoreductase" evidence="14">
        <location>
            <begin position="114"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCF51188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="WWC68968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="401" mass="44627" checksum="2FE860B01CBAF8EB" modified="2016-11-02" version="1">MDATETINNGSALGHATPTMVSPLDKREPYPVFDDFNIDVVIKILSSTLFSPFFVIFLPVTFLSQTHSSHPAFIASCAWTFSICMIATLTHIDRIYKSGGNWLFAPKKLNWDEQIVLITGGGSGIGALLAETLALRNIPVVVLTKDEPKFETPNDNINTYICDVSDYKSVQAVAEKIRKEVGDPTILVNNAGIVKGKLLLDLTEDDIQDTFGSNTLSHFWILKAFLPALLRRGKGHIITVSSVMGIVGAAQMTDYCASKAALISLNQSLRFELDNRYKIAQIKTTLLLPSFIQTNLFSKTIFPNSKLFNFFCPPIQPHIIVKKIIENLDQGTSEIIRLPFYTHFSRILGDDLGIIPTWMRDFIQRIAGADHAMIQYGPKPDAAERFKLEKESINTELSSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I729</accession>
    <name>A0A1B9I729_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Membrane magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_02061</name>
        <name evidence="10" type="ORF">I206_104529</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the membrane magnesium transporter (TC 1.A.67) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012566.1">
        <property type="nucleotide sequence ID" value="XM_019153826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I729"/>
    <dbReference type="STRING" id="1296096.A0A1B9I729"/>
    <dbReference type="GeneID" id="30170430"/>
    <dbReference type="KEGG" id="kpin:30170430"/>
    <dbReference type="OrthoDB" id="44756at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022890">
        <property type="term" value="F:inorganic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018937">
        <property type="entry name" value="MMgT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21181">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21181:SF7">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10270">
        <property type="entry name" value="MMgT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCF51347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC70578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="11628" checksum="3771432DABF96F81" modified="2016-11-02" version="1">MSKVVGQVLVVTAVLALVHAAFSTYEYLSTLKALSKPTNSLPISIIIEALISLALFIPGIAISSDSLEDVTYRGELAKRSIDDQDARMGFMIPSKRGRAIFGDQWDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I7A7</accession>
    <name>A0A1B9I7A7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phospholipid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_02139</name>
        <name evidence="10" type="ORF">I206_104605</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012644.1">
        <property type="nucleotide sequence ID" value="XM_019153904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I7A7"/>
    <dbReference type="STRING" id="1296096.A0A1B9I7A7"/>
    <dbReference type="GeneID" id="30170508"/>
    <dbReference type="KEGG" id="kpin:30170508"/>
    <dbReference type="OrthoDB" id="2261376at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000140">
        <property type="entry name" value="Putative MFS phospholipid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="37"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCF51425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC70654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="516" mass="55836" checksum="A54BD84DDE37D0D5" modified="2016-11-02" version="1">MRLPWSKKDVDLEPKTGDDPKDSNVLERKMGLSKKGAIFAAGASLFSDGYANASIGPAGTIIKTYIYPETFKNRPVNAKLLPAIAFAGIIVGQLSFGWISDKIGRKFGMLLCTGIVFVFSALQAASKGPGPQGTINALLAYRFLVGVGIGGEYPTGSVAAAENTEDPDIPKKSQQRLFVLATNTMIDFAFVISYFVCLVCLWIFGMNHLNAVWRLTLGLGVVPPLFLFYFRLKMREPEAYAKHSMKNTKIPYWLIIKRYWVKLAAVSATWFLYDWITYPFGLYATPITDVADPNGTLYTSIGWGCLINFFYVPGTLIGAFVVDWFGPKYCMIFGLCCQALVGFILSGTYNLLTEPGRIAGFAILYGVFLGFGELGPGNCLGLLASKAIGPTAARGQLYGIAAAVGKIGAFIGTYTFPQIQASFGPPGSYGNNTGIFWLGSGLAVASALITLIFIPNIKPDAMHNEDILFREYLEANGFDTSSMGLKDTVSDVEGNQIAHHGKADKEGLKTTTAPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I7K5</accession>
    <name>A0A1B9I7K5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aspartyl aminopeptidase</fullName>
            <ecNumber evidence="4">3.4.11.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I206_02261</name>
        <name evidence="14" type="ORF">I206_104723</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate.</text>
            <dbReference type="EC" id="3.4.11.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the peptidase M18 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.21" evidence="4"/>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012766.1">
        <property type="nucleotide sequence ID" value="XM_019154026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I7K5"/>
    <dbReference type="STRING" id="1296096.A0A1B9I7K5"/>
    <dbReference type="GeneID" id="30170630"/>
    <dbReference type="KEGG" id="kpin:30170630"/>
    <dbReference type="OrthoDB" id="9880441at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05658">
        <property type="entry name" value="M18_DAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.250.10:FF:000001">
        <property type="entry name" value="Aspartyl aminopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="entry name" value="Aminopeptidase i, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002759">
        <property type="entry name" value="PRK02813.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570:SF3">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101821">
        <property type="entry name" value="Aminopeptidase/glucanase lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11 13" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 11" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="208"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="208"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="223"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCF51547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WWC70772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="505" mass="55924" checksum="79C8D209EFA17F24" modified="2016-11-02" version="1">MKVPPSPPQDATKFCEFVTASPTPFQAVENLTSKLEKNGFKRISEKNIDLNSFKSGSKLFYTRNQSSLVAFTLPNKISSENKKKNNTSISFAVGHLDSPCLKIRPISKKSKLGYLQVGCELYGGGIWSTWFDRDLSIAGRVIISNNTNNNQGESKYISKLVKIDRPLLRIPTLAIHLDRTINEAFKFNKETEFLPILGLVSDQLNNSNSTGNGNGNGISRSGTPQAFRSGTNTPSKSENENDISKMESKHHPLLLAVLADELGCEVSDIQDFELSLYDTQPSTVGGLSNEFVFSPRCDNLMTSFCTIEGLIEAADNGGNEDTIRCVILFDNEEVGSVSHHGAESNLLPSFVERITQLPEYQNIGYHNLLANSFLVSADMGHAVNPNYENKYEPNHSPYINGGIVIKTNANQRYTSNAQTTFLLRRVAKKAGVPVQEFEIRNDSTCGSTVGPHLSTHVRTVDIGLAQLSMHSIRETAGSHDVRYYIDFFKTYFDSLREIDLDLTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I7N2</accession>
    <name>A0A1B9I7N2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DCG1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_02244</name>
        <name evidence="3" type="ORF">I206_104706</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HyuE racemase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012749.1">
        <property type="nucleotide sequence ID" value="XM_019154009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I7N2"/>
    <dbReference type="STRING" id="1296096.A0A1B9I7N2"/>
    <dbReference type="GeneID" id="30170613"/>
    <dbReference type="KEGG" id="kpin:30170613"/>
    <dbReference type="OrthoDB" id="412018at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047661">
        <property type="term" value="F:amino-acid racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052186">
        <property type="entry name" value="Hydantoin_racemase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053714">
        <property type="entry name" value="Iso_Racemase_Enz_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28047">
        <property type="entry name" value="PROTEIN DCG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28047:SF5">
        <property type="entry name" value="PROTEIN DCG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF51530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC70755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="27017" checksum="3FA6DBC5ACFFBE09" modified="2016-11-02" version="1">MTSLESKIHSSIGSPSSPIEILLINPNSTKAFTLDLVPVLKKSIPSDVLIDFLTAPESAPRSINDNHDCALSTTVCEEYLNLNNPALTFLEGYSCIIVACFSQHPLVDSLKRAVKGQSRPAVILGILDAAIYSAMGLGGKFGIVTTGQQWEPLFDEAIASMGLSSRYSGTKGTGFDAVSLHGSEVSDIMIKASIELVKQGAEVIILGCGGMSNMRSTLERDLCEKVGRRIPVIDGVQAAVDLGIGYARMGIAPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I7P3</accession>
    <name>A0A1B9I7P3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin-like protein ATG12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_02185</name>
        <name evidence="2" type="ORF">I206_104648</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
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            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
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            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="kpin:30170554"/>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
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    </evidence>
    <sequence length="98" mass="11183" checksum="2A9294097FBF48DC" modified="2016-11-02" version="1">MLVKYPVNFVAATRDEAKTEPDFEVTIDVDSDQKLEKAFETVIKKLHPEDSEKHKYTFLLQSPNFLPIVINGKSKPSDFPNFSRDWKIIVISAKAKSA</sequence>
</entry>
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    <name>A0A1B9I7R2_9TREE</name>
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        <lineage>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
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    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
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        <property type="protein sequence ID" value="OCF51602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="kpin:30170686"/>
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    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
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    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AA_transpt_TM"/>
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        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF683">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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        <name evidence="2" type="ORF">I206_104760</name>
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    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
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                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
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        </source>
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            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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        </source>
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    <sequence length="454" mass="52403" checksum="F01C9D0056AA000D" modified="2016-11-02" version="1">MQWFSKSKYAKGVVESDQHLTANEGSRPRLAIAHFMLGNTYPFVEKDWLRTFDLVQDTGLDALALNIGPEEWQFAQACTAYRLISTSTYDIKLFLSLDLMVLPKDPKLIFDMVVQIIQSGPSAQLRWDDKLLLSTFGGHELGDEGWKEVLRGIEKTLSEKVFFIPSFFLPPEEILKKDYVDGAYHWNGAWPMDNSTINLDSDQPFLNHEKPYMASVSPLFFTHYGTEGDWAFNKNWIYRSDDLLLPTRFSQLLSLPINKSPEMIQVISWNDFGESHYIGPILGAQPGSENWTNGMIHEGFRLITKYYIKQWKDQIIVKGKNGDGDKAKHEEKAKLIIWYRIQSKEMSLTEDKVAKPNHSEWAQDLLNFFIILPESKYSLKDQYNLYIKNDDQTSKAYSLNVGKPNLINQYFKLGKVEFKIMKNNQEIIIEGKGIDIIQGGNWNYNMWTGIFDAI</sequence>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">CBS 10737</strain>
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    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="5">CBS 10737</strain>
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            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Chapman S.B."/>
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                <person name="Goldberg J."/>
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                <person name="Imamovic A."/>
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                <person name="Shea T."/>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
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                <person name="Hansen M."/>
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                <person name="Imamovic A."/>
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        </source>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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                <person name="Young S.K."/>
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    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Roberts A."/>
                <person name="Saif S."/>
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                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">CBS 10737</strain>
        </source>
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            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Dewar J."/>
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                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
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    <dbReference type="KEGG" id="kpin:30169649"/>
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    </evidence>
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    </evidence>
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        <source>
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    <sequence length="278" mass="31754" checksum="9E5452195F235343" modified="2016-11-02" version="1">MPLLTSRARHFLQPLKPLTLSIGFSFIVPLRFFGSAPDHSKVQCTRRLIRQPSPAASRESPYPIVFLRMKGVEGLEDETDWVDWSSMFAEKGYTSVEIDISSPTEFSKSSELEEMKEDISILKSMVNLLSSEIRLLSIPFPPILIAFGKSTILAQSFIEDNPSSGLILINPLSDKDERSIELQNKSNFKFPNFTFEPHFPILILSNQQSLRNLSVSNRLIREYGQLPNPNTDEEKKGWFKNRRNKGIEIGVLDEEGFESGLNENGRIQVERWMDRQGF</sequence>
</entry>
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    <accession>A0A1B9I9Y6</accession>
    <name>A0A1B9I9Y6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_01553</name>
        <name evidence="4" type="ORF">I206_103444</name>
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        <lineage>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
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    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="OCF52267.1"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="PPM-type phosphatase domain"/>
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    </feature>
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    </evidence>
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    </evidence>
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</entry>
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        <name evidence="6" type="ORF">I206_103331</name>
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    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
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        <source>
            <strain evidence="5">CBS 10737</strain>
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    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013593.1">
        <property type="nucleotide sequence ID" value="XM_019153432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IA95"/>
    <dbReference type="STRING" id="1296096.A0A1B9IA95"/>
    <dbReference type="GeneID" id="30170032"/>
    <dbReference type="KEGG" id="kpin:30170032"/>
    <dbReference type="OrthoDB" id="426865at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000007">
        <property type="entry name" value="40S ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF52374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC69392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="150" mass="16413" checksum="C2039DC26FB911A7" modified="2016-11-02" version="1">MSAVQTFGKKKTATAVAHVTPGRGLVRLNGSPISLVEPVVLRYKVYEPILVVGPEKLANLDIRLRVKGGGHVSQIYALRQAIAKGIVAFYAKNEDAASALELKKTLIAYDRTLLVADPRRTEPKKFGGRGARSRRQKVSLIKCMLGYIPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IAC7</accession>
    <name>A0A1B9IAC7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_01707</name>
        <name evidence="12" type="ORF">I206_103287</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013636.1">
        <property type="nucleotide sequence ID" value="XM_019153475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IAC7"/>
    <dbReference type="STRING" id="1296096.A0A1B9IAC7"/>
    <dbReference type="GeneID" id="30170076"/>
    <dbReference type="KEGG" id="kpin:30170076"/>
    <dbReference type="OrthoDB" id="2018507at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967:SF57">
        <property type="entry name" value="AUXILIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="130"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="433"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="580"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="445"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="502"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="531"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="604"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="616"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="647"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="730"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="779"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="821"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="842"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="868"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="881"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="902"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="916"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="927"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="969"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1002"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1049"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1080"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1155"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1182"/>
            <end position="1210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCF52417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC69349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1220" mass="131077" checksum="13E29AC3D37CD258" modified="2016-11-02" version="1">MYSSSYSPSASPYTSPPPPPHDPYRSSPIPVNPKQPYNATFSPPPQMPNNFAPMPSGQSSHRYQQYANPPQQYARAPPNRYSSPLPPQGYVNVSNGYPQQQQQPPPPPPPQRHKGTLAPGQIVKVGDQAVRIERYLSEGGYAHVYLTTSEKPIYPPTKGEKKGRWGEKGYTEHCLKRIAFEDDTVWIDVKKEIEVMKSLPPNPHLIQYLGSAHSRLPTGGHEVFILMEFCSGGGIIDLLNKRLRDRLKEIEILNIFTDVCEAVAAMHHLSKPLLHRDLKIENVLSQPISTSPTPQRPNSLMFKLCDFGSTTFPADKPPQSKVEADALAMDLNKHTTLQYRSPEMVEPMLGLPVGLPSDVWALGCLLYKLCYYTTPFEEHGPLAIVNAKYTFPPVPAYSPRIQHLIASMLMEQPVRRPTVFEILKIAHEMSGTKPEIDYPIPSRSLGASSQPHQPTRINAQTSNLLDFTGSSSPLNGTPTLQPSFASSVPPQRRGRPTREGSQKSISQPYAATSMPTPPSLPPADHAPKPNIQVTGEMSKPQSAPTSALKSSPGLDAFGMPSLPASSSYKAENRGFGDSFAAHASKTGGFNGNSRLGANLPRPPSTSGFGDSFGTSEPTSLSARSPGLSSLNRVGSNQSGSAAIKQDSPITTVKSPDSSSSAPNGESNFETRFPSLETLDSDHFSPPPQQSQPKPESLISPVTLSPPTRPTFDNRPSIMGNMTGGNLKSPMISTAPTDHPQPRSTQVTGTAFKAVKSPPSSQQKTDYFGSVASSAVKPGVSTNVSSSAGAKSPPPRDLMDDDQSGSDSLKLVPMQPGRSTTPLSASSMTNPSSSPNHLNTSRPQGSPASAQAAPLSGHHRPLLPHINSAKPNSNINSEEWSPLEKMRLSQDANRGEERKVEIELDSSDEDAFPEEASGTQYKPLTSPSKDKGDEQLSRQKTSDRASTFGRLSPTKSRDPIKSATVGVPPSAQSWTSGQRSRPQSMFVTPSSSSALSKGFRLSESPSNGNFPQSESTTRPSHGRKGSINDIVSKYENLKPPSASFKDLKNPSPSTSSAHGQDGTFTNGAKKPSIASKPQALRKSTTEQSAISPTYASNETTKNASDSASGIAKPIVNAKGSPLIAPKPVRHGETPRPEGFSRSSSGRAFPITKPKPSSINTSSTQNINQSEKIEDKDENGNGSGMSSPEKQQSVNSLIARWNQGQTANSNANKVVPKRGGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IAD4</accession>
    <name>A0A1B9IAD4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_01857</name>
        <name evidence="7" type="ORF">I206_103139</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013784.1">
        <property type="nucleotide sequence ID" value="XM_019153623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IAD4"/>
    <dbReference type="STRING" id="1296096.A0A1B9IAD4"/>
    <dbReference type="GeneID" id="30170226"/>
    <dbReference type="KEGG" id="kpin:30170226"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000036">
        <property type="entry name" value="NADP-dependent oxidoreductase domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="18"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="4">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCF52565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC69202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="329" mass="36357" checksum="46307EDD6EB8A05F" modified="2016-11-02" version="1">MSLGRTVKLNNGVVIPQVGYGTWQAAPGEVEKAVEEAIKVGYRHIDCALVYRSFSIPLRVFIVATGIKASGVPREELVLVSKLWNNSHRPENVEADLDLTLKQLGTSYLDVYLIHWPVAFKPGKDLFPKDSNGVVQLDEPAEKGGPSIVDTWKEMVRISKETKKVKAVGVSNFTVEQLKKVIDATGVTPSMNQIELHPSLIQPELFKFCNDNGIAITAYSPLGNNITGKPRVIDHPEIKKIADRLGKSPAQVLIAWVAKQGFVVIPKSVTPARIKSNFEDFELSDADLEEINKIGLANQVRSNIPFEYETSWPVDIFGTPEEKGQVKAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IAR0</accession>
    <name>A0A1B9IAR0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rieske domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_00001</name>
        <name evidence="7" type="ORF">I206_101323</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF52705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013924.1">
        <property type="nucleotide sequence ID" value="XM_019151786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IAR0"/>
    <dbReference type="STRING" id="1296096.A0A1B9IAR0"/>
    <dbReference type="GeneID" id="30168370"/>
    <dbReference type="KEGG" id="kpin:30168370"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03477">
        <property type="entry name" value="Rieske_YhfW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
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        <location>
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    </evidence>
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        </source>
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        </source>
    </evidence>
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    </evidence>
    <sequence length="530" mass="57635" checksum="55BD24094C64C450" modified="2016-11-02" version="1">MSGTDSSGASKTVWLERDDLLSKAPSYPQLTTDAKTDVVVVGGGMAGLHIAYELLSSGQKKVILLEDGKIGSGETGRTTGHLSADSEYNDHLKLHGAEGTAQIAAAQQAAIDRIATIVDKHQIDCDFVRLPGYMFQGLPTSSADFKVDTLEELYNAAEDTGKLDVTIVNDAYIKGFKSGPAIRFGNQATFHPTKYLQALSKVVSDLGGEIYEKTRYMSHTEENGGVTATLDNDKKVQAGSLVMATNVPLQKLVMIERMEAMRTYAIALKIPAESVSSNGEDALWWDLGDPYHYVRVTPSKQEGYKLLVVGGEDEKVGQHDDYEERFQRLESWARERWTSAGEVEYKWSGQVMDSADGVAYIGRNPGENNVYVHTGDNGDGLTYAAVGGIVISDLILGKENAWAHTFSPSRQHSGSHLKQALQTLPGIIKENLSDQLYFTKWVTTCAKTMSDIEDLVPGQGDVVRQGLSPIAVYKDEQGGIHKMTAICPHLKGIVAWNSAEKSFDCPIHGSRFTCKGEVVNGPAKAPLQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IAZ6</accession>
    <name>A0A1B9IAZ6_9TREE</name>
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            <fullName evidence="7">Mss4-like protein</fullName>
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        <name evidence="5" type="ORF">I206_101219</name>
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        <dbReference type="NCBI Taxonomy" id="1296096"/>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
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    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="OCF52808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="WWC67311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <source>
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        </source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF52808.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC67311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="19437" checksum="C332D653402BB9D9" modified="2016-11-02" version="1">MTQPTQAEIFAALSAQSSSSSRFKPSTKEYTSFENPKDEIVSSSNSLNNRKIYCSREKCSSLILLKGVAKLIEIEGSILPDDSSSPFIKSSSPHLYWSIPSGPFSFENIGFSRPDTSIINDSLPNFIPKDVNEKSKIKWLICAECDLGPIGWSFEGGKGAWLDVKRLRYEDVKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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    <protein>
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    <gene>
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        <name evidence="3" type="ORF">I206_103089</name>
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    <organism evidence="2">
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        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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        </lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013833.1">
        <property type="nucleotide sequence ID" value="XM_019153672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IAZ9"/>
    <dbReference type="GeneID" id="30170276"/>
    <dbReference type="KEGG" id="kpin:30170276"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
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            <end position="105"/>
        </location>
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            <begin position="79"/>
            <end position="91"/>
        </location>
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        <source>
            <dbReference type="EMBL" id="OCF52614.1"/>
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        <source>
            <dbReference type="EMBL" id="WWC69153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IB70</accession>
    <name>A0A1B9IB70_9TREE</name>
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        <recommendedName>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
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        <cofactor evidence="1 9">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the 2-oxoacid dehydrogenase family.</text>
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    <dbReference type="EMBL" id="KI894007">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC67320.1"/>
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    </dbReference>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:lipoic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000013">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
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    <dbReference type="InterPro" id="IPR001078">
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    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
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    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="E3-bd_dom_sf"/>
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    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <dbReference type="Pfam" id="PF02817">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5 9" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="11">
        <location>
            <begin position="56"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="12">
        <location>
            <begin position="256"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="182"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
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    </evidence>
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            <dbReference type="EMBL" id="OCF52799.1"/>
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    </evidence>
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            <dbReference type="EMBL" id="WWC67320.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IBZ5</accession>
    <name>A0A1B9IBZ5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Signal recognition particle subunit SRP68</fullName>
            <shortName evidence="10">SRP68</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_00479</name>
        <name evidence="13" type="ORF">I206_100847</name>
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    <organism evidence="12">
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        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the SRP68 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014397.1">
        <property type="nucleotide sequence ID" value="XM_019152259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IBZ5"/>
    <dbReference type="STRING" id="1296096.A0A1B9IBZ5"/>
    <dbReference type="GeneID" id="30168848"/>
    <dbReference type="KEGG" id="kpin:30168848"/>
    <dbReference type="OrthoDB" id="10255118at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15481">
        <property type="entry name" value="SRP68-RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.40">
        <property type="entry name" value="Signal recognition particle, SRP68 subunit, RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026258">
        <property type="entry name" value="SRP68"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034652">
        <property type="entry name" value="SRP68-RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038253">
        <property type="entry name" value="SRP68_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 68 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16969">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038995">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="590"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="621"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="633"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="643"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCF53178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC66940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="653" mass="73542" checksum="FE14F9B8A25EBE26" modified="2016-11-02" version="1">MSKVDVSFPLLSQLSKERAVYGLRNGDHERYRRHCTNKIHRLRTTTNQTCGKGKQYKAPPKLEVENIKDVRHLQLLLFSAERALAHSHEFKAQKAKPNPTSSPYQLKKDQISWLRRSLKLSTNLFELVNNAPTDDKVDGVKLNVRTKVEVTIYHLLVRSELYFEKANYGNCLYDLIVVRKLLNILNENSKNSYDEALSNEFIDLNEPLIRYCAYKLGRSESHDIQGIVNDIEDKTLEEESLPGFISLSSNLKEELSNQMEVDKAKLQPFVFAEQKIEFRNPELVNVIIKVQETLSKFESKRNNNKNRSKNVSMKGWDKVLSVLGEAEGIARKLKDDHEASGSSTSLRSTQITSSLNLAHAYIVHLLLSHRIKRDLSLIDTLQSNFSSFLPANVGDTKIKGGKTRVEEVVKGLGGIIKLLDTVLQSLRGISDLSIVQEKEGVRIGVEGLENYYHALKCFTLARLHCLHPTPSYSSAVALLQKATPSIHQAKSSLIDPITPIEEEILPISSEQIDNLEEDIKVLDIGAKKGLFSQNIEKPVFFDMAFNYIDIPFDELEILSGKKEKTTSTGTTTTVVENLTSVGNKAVEGIKKLGRETRETTPAVEIRPPASTTRNTKQPAKEDDDDEEEDTEESQERGQEGKKGWLGGWFGRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9ICB9</accession>
    <name>A0A1B9ICB9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tetratricopeptide repeat protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_00563</name>
        <name evidence="4" type="ORF">I206_100764</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014481.1">
        <property type="nucleotide sequence ID" value="XM_019152343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9ICB9"/>
    <dbReference type="STRING" id="1296096.A0A1B9ICB9"/>
    <dbReference type="GeneID" id="30168932"/>
    <dbReference type="KEGG" id="kpin:30168932"/>
    <dbReference type="OrthoDB" id="1872379at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052769">
        <property type="entry name" value="TPR_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="201"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF53262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC66857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="38740" checksum="EBEFDEBF45CF722E" modified="2016-11-02" version="1">MSNISEPTFDDLPTFDARKFEPPSWAKETFHQWGENHGESSKSSKSNDKDNVTSKDEYNQSLNLNNENSDDEIDIWEDAEEDIIEPEEAKFNNDELKDLLFKAKKLKENGNELFKNKPPNYEKAIEFYLKAINHLPPTPELDQKEIIKEQEEKVKISNSGIEEVTDEEAFKIQENSNKLNNSNQEESDRINIQLEIKELTKAVWGNLAACYIAIKDDKKAVEACTEALKIDPKYVKGLHRRATSNERIGDLTALLSAKEDYTLLQTILPKSSTILPFVKKSLSNLSSQIEIKEKEQMDEMMGKLKEMGNSLLSNFGLSTDNFKFEKQDNGGWGMQFER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9ICY8</accession>
    <name>A0A1B9ICY8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chitin synthase export chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_00565</name>
        <name evidence="13" type="ORF">I206_100762</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CHS7 family.</text>
    </comment>
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        <property type="protein sequence ID" value="OCF53264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC66855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014483.1">
        <property type="nucleotide sequence ID" value="XM_019152345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9ICY8"/>
    <dbReference type="STRING" id="1296096.A0A1B9ICY8"/>
    <dbReference type="GeneID" id="30168934"/>
    <dbReference type="KEGG" id="kpin:30168934"/>
    <dbReference type="OrthoDB" id="2189463at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022057">
        <property type="entry name" value="Chs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329:SF2">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12271">
        <property type="entry name" value="Chs7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="46"/>
            <end position="70"/>
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    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="110"/>
            <end position="137"/>
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    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="149"/>
            <end position="173"/>
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    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF53264.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC66855.1"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1B9ID75_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_00791</name>
        <name evidence="3" type="ORF">I206_100535</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014705.1">
        <property type="nucleotide sequence ID" value="XM_019152567.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A1B9ID75"/>
    <dbReference type="STRING" id="1296096.A0A1B9ID75"/>
    <dbReference type="GeneID" id="30169160"/>
    <dbReference type="KEGG" id="kpin:30169160"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF260">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="48"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF53486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC66632.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="481" mass="51856" checksum="60A163409AAA34CF" modified="2016-11-02" version="1">MPIAINNTPPAHPHLPIPLGGLSVWQHSTRDHPLLNAGRDDPLPSEADVVIIGSGLCGAVTAHSLLNDPSRPGSVVVLEAREICSGASGRNAGHCRPDESRGFPAFSALHGAEEAKRILKSERVTFEKVNEFIEKTKIDCEWTPRDTYDVSLSEDFKQYASNALKDLLEAGGQPEVEELSKDQAIKETRIGIAHGAVKWWAATVNPAKLTLGIHQLNQSLGGYSLFAYAPAHAVTQAEDGESWVVQTPRGKVKAKKVVYATNAYSDALLEELDGLIVPTRAQAIKLSPAPAGPEQFPRIEGSYSLRFLPQHFYSVCSRPDSSITLGTSRKWHGMSPATAASIQNTVDDSSYSTEVTDNAVDQFSKLFPEGGWSADGIQEGKAKGYEYSWTGIIGMTPDSVPFVGSVPGKPGQYIGAGYNGHGMARIFICAPALAKHILTGEWDDVMPSSFRITEERLNKLRKGLDKGKLSHNGGLPSKLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IDS3</accession>
    <name>A0A1B9IDS3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_01086</name>
        <name evidence="5" type="ORF">I206_100239</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Sykes S."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
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                <person name="Young S.K."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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                <person name="Litvintseva A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="Mohammad A.W."/>
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                <person name="Litvintseva A."/>
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                <person name="Mohammad A.W."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="Zeng Q."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
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        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019015015.1">
        <property type="nucleotide sequence ID" value="XM_019152877.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30169472"/>
    <dbReference type="KEGG" id="kpin:30169472"/>
    <dbReference type="OrthoDB" id="2554322at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="762"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="860"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="976"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1067"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="331"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="544"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="873"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="899"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1009"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1074"/>
            <end position="1090"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF53796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC66321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1351" mass="144950" checksum="E8747E2D244410D6" modified="2016-11-02" version="1">MLEEMSNSPSGSRRRPKPTQENWDDDFEFSLPKKAGSSSNSKSRVKDENVPLSTTRNESPTEDWDENWDESPPRPLPPPIMTTQHQRKKTSIPPPISIPSSSSSRGPPRLSPSQTSSLSISPLPTAHSSPQHPLLPSRSHSSAGLSLEQQPRLRSGSTTANGTIARNKLIKRHPSTSFVPILSHSSSHVDLSALSEASLRSSNVANRSSPNLPPGSPYLPRSTSGEQMPPPPLPAGGILSRARSRSRSKVRPDSKNGVRVSSIPFSPSKEDMTDTEKEKRPGFWKRLSGAPVTASKQNDGTTQHRRRRSSSVGSKQVISGSPRPPVPPLPTNLRSPSGASSTSTSSAKSGPTSAFSALLRRSSSSLSRRTDKSKETPPPSSYPYFTRHGASTSSINSVVQQGVPIPSRRGNITPDLPSSASFTGGFHLPSPSPRSPYHAPQFRMPSSPIGQSEIPPLPHSTSFPGPIGRQQEGSSSDTETEGESKTPKKRKKIRPVSALPASTSEIAGTQIQNPIPGLPISRQHSCEASIGLGRSSDSPSGFASTTTSTLKRLSSLSKKHGRRLSGGWKFGTASSTDSSKSTMTPLEPVVGSPSKPHNRDEGQPVSPASPTPDLNPQSEEELRKAIRAGSVSAPTSLFMSPPSSLDSQTSTAAEITKFTPSEALAKEKEKKDKHRRRQSWNDFVIPREVMMKQKGLKEGIGAVKMFAGGVASLKTLLNTHADLRDRILASGTPSDAAYFATLDAEFEQWLEMAVVLIEVGSTGTDPANQPSFSSPPRSRRVTLASDESKAASATMSKAISAPNPPVQLSAWRKASLPDPEEHSSGNGTYGPPNPDPDHWRASTGRQDLSKRQLEVLRTMLRTPVANTPDRPVLGLRTSSTLSASTNSSYLNTKIGEDQGSPSPQRLKSTRSTRGVTPESDISFPSPGDSAHIQPSASFPSPLSGRIQHHPPSQAQKSLKDRRASKAGLAGLKEFLRSLKKDRGTQRLPSGDAGDSSPLRIKSRMFGIKASTSPPASPTSPLSPAFTKNPNDVFYPTQRSTFSALGSAASPGIPETPQTAPMLQQRFSARNGSRSRADTDSSPKLGPEQKRPSIRNIFRTTSGNWSELVNSSNNIGPLSPGLSKKSSIQKLGFSKSNSAQILSKISVSDPIPSKIPLSASSRTLYANDLNPYFGATGEDQSEMTLRAGTAKKRTSGLGLGLGWPESQSQSNTSSIEPSSGVAIGEMGTVFGSPSKMDYTFKASINMPKSPSKIRLPSNRSSNSISTLNSTTSIRIPSNENQIKSLKYVEYESNDSQFPQNVEVQDLTIALTPENLPTLLEYLKQCERMLGYWRERVEEIMGVGANLAGNRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IE22</accession>
    <name>A0A1B9IE22_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Nuclear pore complex protein Nup133</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_00815</name>
        <name evidence="12" type="ORF">I206_100512</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin Nup133 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014729.1">
        <property type="nucleotide sequence ID" value="XM_019152591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IE22"/>
    <dbReference type="STRING" id="1296096.A0A1B9IE22"/>
    <dbReference type="GeneID" id="30169184"/>
    <dbReference type="KEGG" id="kpin:30169184"/>
    <dbReference type="OrthoDB" id="103454at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037624">
        <property type="entry name" value="Nup133-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405:SF11">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="10">
        <location>
            <begin position="91"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="9">
        <location>
            <begin position="840"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCF53510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC66609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1221" mass="136424" checksum="247396DBDF90FE4F" modified="2016-11-02" version="1">MFNSPSTRATPRKANSRASVARSRHQTPSIFAESASLSQAPTPSIRSSRLAVVRRGASPTSSAGDTVRTTRVEEGYEKDRVFWSKDERHLVSSLGPLPKEVASLVKNSDFVAHPIAGHVDPKSGFAMVASPSICIAWNYTKRTHSAPTTYTFPAPPVSYSTTPTQPPSLAALYTGSASSEPGIILVSTSGEIRFWESMSVALANVDRFQEIYVEVGEDDSVEKLWKTDGHNFLLTTSTSIAFRLTISSSGGRLVPTLTQLTRPGGMFGRASPQLFNAREDRGGVSSVTGAGGDLYMMARRMLQKWAFGADGHKYIQEYDLHEAIGSWCFDSWSSGNVSLDLNDLVAFGQDELAVLISYVEQQSGTSEYPRIHNSHAIVLFSIHPRSQSLVISRVVDTSYLAHSDPRMLDVPRLLVPPGSSMAFIRFAEVVLMVSLDEGSPYEEAITLKDSGRNAFIGAGSIASTSSKKGHGLPSIVAIPALGGLMSIEALETSGSSDPLTQITSATARLKSKMEQAVFFGERSDNPLSFDLPAGFQGDLAEAAEAVSAEIVSSNSSYMPGLFELRAHLSDRLLRLKELMNFIRHNGLLTILPQSTRRRLSRDAEKIKGAIDLWDYQNRQMDQIHTRSPQSLLSDSIHTYMHQADIVEEEDFVRLFFRSQVQNLDKLLEIVFTTARSALDSANRSELSSWATEANRIFIIVERAAAQYREEELYTYEIDREKPAIEIWTAQDSLLEALDFLYTTTEQLIKERSRDLGSVIDEPPSDTAEPGLKREQQLQSRLKGQMAILAAALCTNMEDKCRATSRREIDEGADPQEGVQLREKWAEMKPRVIRPLVAIDRLSEAYELAENHTDYLTLVILCHNQAKSDTARLQRYIERFGEEFAFVLYHWYIDQGQAYELLNQDEVYGVLVTRFFAEHQCPELAWMHHLAFRRYDGAAIALKDAMADENTTKLEQQQLIGSIAKLAAIADVRSNGVSESRKRLLIELDDELDLVHIQTTLIDYLSPPQRRHAIKLDEQITLLADRPAFKRLFINLAEQLIRGLALDLEGLIDVLTLKENFERTGDAALALERLVGDTALPEGRKQVALLSIWRRVYIRDDWAAISNTTGRSEQAQRSKVRGTLAYQTIKLVNDIKDFPRNFILSPFTSSQPPLPTELTARFPTFSAEDISSLMNDHEKEIEILNRYLSENALEERIREVAELVKTDIEDEKREEGDVDIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IEL8</accession>
    <name>A0A1B9IEL8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Solute carrier family 25 (Mitochondrial 2-oxodicarboxylate transporter), member 21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I206_01037</name>
        <name evidence="14" type="ORF">I206_100288</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014949.1">
        <property type="nucleotide sequence ID" value="XM_019152811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IEL8"/>
    <dbReference type="GeneID" id="30169406"/>
    <dbReference type="KEGG" id="kpin:30169406"/>
    <dbReference type="OrthoDB" id="434783at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051752">
        <property type="entry name" value="Mito_2-oxodicarb_carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356:SF1">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="20"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="110"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="203"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCF53730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WWC66387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="296" mass="32000" checksum="03A11B71AE634C2C" modified="2016-11-02" version="1">MSAAAANPKPATELKKPLPLPFAYTFASGAIAGCTELLLLYPLDVVKTRQQLDTAKTSTGMIQTFKNIVAQEGPGRLYRGILPPLFMEAPKRAVKSSWGAFFTNNGQRKNTQTLAIVTGCFAGATESFVVTPFELVKIRLQDKNSSFKGPLDVVKHSFKTSGPLGLYQGMEATFWRHWWWNGGYFGAIYGVKGQLPKATDKKGELLNNLIAGTVGGFVGTALNTPFDVVKSRIQLHGTGEWTYPALIQVARTEGLGALYKGFAPKVLRLAPGGGVLLLVVEALSTVFRGYLGPPYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IEP2</accession>
    <name>A0A1B9IEP2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_01218</name>
        <name evidence="2" type="ORF">I206_100108</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019015130.1">
        <property type="nucleotide sequence ID" value="XM_019152992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IEP2"/>
    <dbReference type="GeneID" id="30169587"/>
    <dbReference type="KEGG" id="kpin:30169587"/>
    <dbReference type="OrthoDB" id="2558794at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCF53911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC66207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="96" mass="10632" checksum="83EF003DB20CB45D" modified="2016-11-02" version="1">MFARSALRTTVQASKSMVARQQIAKRSYTIPTAGEQLSAFFKARPVPVDVYPILTFTAMMCSYCAYMGTKHIREDSDHVRWGPGVGGVKFELPGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L044</accession>
    <name>A0AAJ8L044_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Trafficking protein particle complex subunit 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_100566</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058332.1">
        <property type="nucleotide sequence ID" value="XM_070202231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L044"/>
    <dbReference type="GeneID" id="30169128"/>
    <dbReference type="KEGG" id="kpin:30169128"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034498">
        <property type="term" value="P:early endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055505">
        <property type="entry name" value="DUF7077"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045126">
        <property type="entry name" value="TRAPPC10/Trs130"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022233">
        <property type="entry name" value="TRAPPC10/Trs130_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056913">
        <property type="entry name" value="TRAPPC10/Trs130_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251">
        <property type="entry name" value="EPILEPSY HOLOPROSENCEPHALY CANDIDATE 1/TMEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251:SF3">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23274">
        <property type="entry name" value="DUF7077"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12584">
        <property type="entry name" value="TRAPPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23036">
        <property type="entry name" value="TRAPPC10_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="TRAPPC10/Trs130 N-terminal" evidence="6">
        <location>
            <begin position="24"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7077" evidence="7">
        <location>
            <begin position="742"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="domain" description="TRAPPC10/Trs130 C-terminal" evidence="5">
        <location>
            <begin position="1038"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="453"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="463"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC66662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1213" mass="137188" checksum="F22BEE1EEB732CCB" modified="2024-07-24" version="1">MPRPVTITYTLHPSYTSPSSSNQTNQILNLAIQGIKQHLPLRNLHWKSSTRTSLRTIQEIDIELIELGEISSTTNNNKFNLGNESSILDNPLVNLCLVVCEDAEIYKNQTRNFIRDWLSLLAARRTPHAPLIVLVNPPNQSGGSNSGSKNVWGKDKGVLGKIKNDFNVGKRDRCIQLNLPRESSGLNDPAIWPELINKLKESLISAFDSLIIEREEEVKRGESQRLNIGWNFCTWFLLKESLANSFEAVNLPEDSLIIYEELEASFFQVLKEQNLSWFGISKLGAMNFGDDSLPILDVSQKPYRELIRNSQISIFDFRIYLFARQGQLLGKLGRITEVAKRGQWFVASLTRRLREAENSLAEHFIESWTYTACMDIVSRCDQWSRIDRPNGDYSGLVAYESARSELLDIARIQVERIGVSSGHLPPIYPFNPATSPYPKLSEEEDVLFETTSNGLSDDEELQHTPSNNQGSPTERPELSNEQLIDAQKDQNNCRSLYLGLTQKTIKAYGSCGKVNSVIRLKADLAALALYTENWVEAYDLSRALARDCAELLTWDPISKFALEGALQAHRELDKEKDEDWENLALAYLRVCALVIDEKATDQQDEDQYQELRKVVDGLKETDNEQEVEGHKAFNVRLISEAVRHEVGGSLTSVQVEVNNILPICVDADGISIDLADSDGEIITFSSDGKTLQPGTNAMKASCSTSTQGLYTLHSATIVLGSISFTYDKFNEGQTLRVKRDPQGIEAKLRMPYNIKLDEDPKVVVEVRSGIVDMKNIKIGLRSLIPEVRYLLQDAEFDERLVSLDESGLILFSDIQSGGEVVISIPYAGVPQGEYAKAQITIQYDTSSSSRDWIDSQVVFMGLPLTVNVQDFFRPDCLLSHFTVASDGREYLRIASVELTPPEGGAYEVQASRKKWDDTITVHPNQPLSCLFKVKQLHKDDQGAVLRLKIRYRSLEEEVRHAIEYAFRQLSPAARDKIRNITREWMNDKAKWLEPYLLGISLAQTLGEIFESQNIDGLESVLKAMSKDENKIWRTLEIPVDVPQHRLLTIIRMNPTTPLNQIYEGRAINMKLSLTTSFSWCGQIIKNENEKKMLVFDIQNNEDWLIVGKKKGYYMANPNEIEEQDIILIPMKSGQLFLPTINIDLLSNIIPNQIQIQNQNNSRSGLISNENEILCETYFENSGESIIVLPCKKEINHFLPILIPNGEAWESERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L2K6</accession>
    <name>A0AAJ8L2K6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_101703</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058542.1">
        <property type="nucleotide sequence ID" value="XM_070202441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L2K6"/>
    <dbReference type="GeneID" id="30174697"/>
    <dbReference type="KEGG" id="kpin:30174697"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF78">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="19"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="54"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC67790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="670" mass="73794" checksum="AC09C4C6E4FC0DEE" modified="2024-07-24" version="1">MSPNPEGESSRTQRRSTRACDNCKSRRTRCEYDNDNISCKSCVENGLECTFMAPVRKRGPQAGGRKGDRRSASPRSSDRWSTKPKSPENDSQRVSPPYPRRTLPFGGVPSKLVDQLLPLYFTHNVWPLVYKATFNPHTAPSPLLLSMLAIAACVTPLKDGDSFPSERLFRMAEQSLHESRNECRIDLIQSLLLLSLRQTGCGDKQSASMYAGRACCMALNMGLNLAPGGLGKLPDPTEQEIRSRVYWNTYVLDKTLAEETGRPFLLTYRRTTTALPSTSELEEFEAWPPPTISATISSSVGVIPRRGHVLSCFAWTCRLAMVVEGVLEMDPTCPPMTTEWDNQFLEDLPGKQQYMAERPATHLDGWYRALPLYLNVDGSASPLPHHAVLLAWYHTTRILYHSRFIRSKGIAQSPMVNTSLQPISARQACSDAAQATIAILTLLDRHNLLTVASADVLHILSLTALFEAKVNFAQCCIWLREFSKSWPAASSHRLFFEGLIKGGLHLSSTESDQPSDPLPGSGDTAASPSLPAGLHAIRRNLSISGNVSPIRPDPSDIPLESTLNPSNLFQLPQLYWNHFNTGSNFNNALGTVTNTDSTWNSDFDIGLNTNDINDTFDTNWNNQVGGVVDMSAENWLESLTTSSGQPDNSISGDAVQSALMSFMIQAGRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L3L8</accession>
    <name>A0AAJ8L3L8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_102728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058717.1">
        <property type="nucleotide sequence ID" value="XM_070202616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L3L8"/>
    <dbReference type="GeneID" id="30171452"/>
    <dbReference type="KEGG" id="kpin:30171452"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="539"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC68793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="607" mass="64698" checksum="396C56034E7E5D66" modified="2024-07-24" version="1">MVSNRHDFTDSEPENEVDSGVDSQAGPSNPRKRQLSEGVAESSNADGGDSRGGSEDFDDLLANDEDVEERTKPVPPPKKAKKNGTGKPLKITLRPGISNLINSQTPPLKSNSNKKSNSTRHSDRSSLSPPPPITLKFGLKSAMAEKAAYSSSEDDDPLPVPAPPSSKKKKPSSTTSSASKSKAKSQAEKVSSTATSSALAPRKSYDWLAPSAAGASHRGPPERGEKEKEKERQDSINNDNAKITGWSPADEAIGGLLDDAPESFEKKPVKKSHKKKAADAPPGPGKAWRKGIKKGMTTAVKAEDGLFTPSGSPLVHAVTPQSREGSPDPLEISPRMIIERPIAPAISRAPREPSPPFVLADAKVLGFPVYPNPIQVPKVPLGPFPKVTQYFAPINGGDVGPFPRKEPVRNWTHTDKIITGIGGGQLKLKSWVSGPESELSRLVQSDKEANEIARLAKSKTNATNKAAGQGISTGTVTPNSNIIEERPLLSTNNSFDASTSTLPTPILGPINNEEKQVRGDEEMSEIADFDEDLLPSRATTPVSISTPTTTTTTTTTTPKIKLKSNSTGGSKTKKSAPRKSNLRQEIVPSEENSEIDITIAENEVEAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L3Z7</accession>
    <name>A0AAJ8L3Z7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I206_102857</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058742.1">
        <property type="nucleotide sequence ID" value="XM_070202641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L3Z7"/>
    <dbReference type="GeneID" id="30171577"/>
    <dbReference type="KEGG" id="kpin:30171577"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="264"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="694"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="729"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="813"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="264"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="381"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="696"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC68921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="842" mass="93460" checksum="148CA74CE7079E6A" modified="2024-07-24" version="1">MTLKDDPQESLEKTGSHKTDPAPSKLKDLSDSEVLQFPGITREHWWQLWRPRHSPPPPKATLEEAEIIPLAYVSTLSKLTFQMDPSREEKRQAKAQHWNDQLNTARPRRSLKAKWRIKAMSNRGLPEDLSNYGLLDTYLHRYQALELEWRQRTGRKTGSITWALNDVMTGFWAGGLFKVASDTSQLMIPLLIKALINFSKEVCLSTSVFLPINGDRVGGRAKHPNGKLLTYLSSDISRIDYCAQWFHAVGSLWLNHINLSVDPLVLLIIQIGPSALVGFSLFVLLAPLQTWFMKLSFKVRKKSMKWTDSRSRLLRELLSSMEVIKVFTYEIPFLKPFSVPALASVLAFVTYAATHDSLDPVFEAEVRDKSHVIDISLKLAVTVSNATFSWSSKSNVESEPGFKIEDLNLNIPRGTIVGIVGSVGSGKSSLLQGLIGEMSILTGSVTFGGRLAYCQQNAWIQNATVRDNILFGQVWDEPRYWKAVKDANLVPDLEILGDGDLTEVSRFVSASANTANKMCINLSGGQKQRVNIARALYYNADIVLFDDPLSAVDAHVGKALFENAIMPLASQGKTVLLVTHALHFLPAVDRIYFLSNGSISEQGTFSELSQSGGAAAKLFSEFGGQEKQKVEVPDELEVQDSQIDKQTQLLSNKSMGKAVGTGKLEGRLMVSEIRKTGSVVYAGYLHAGRSRYTFPLTVLFATIMQGSQVMATVWLTWWQDSHFNQTWSVYQGVYAALGISQAMFTFAMGATLGVMANLASQNLHSAALDNVFYSPKSVFDTQPLGRILGVFGKDIDTIDNQLPDSLRMMAMTLVTLIGSIAIITVFLHYFIAVIFFVGVGYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L575</accession>
    <name>A0AAJ8L575_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vacuolar protein sorting-associated protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_103766</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC69823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058929.1">
        <property type="nucleotide sequence ID" value="XM_070202828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L575"/>
    <dbReference type="GeneID" id="30176084"/>
    <dbReference type="KEGG" id="kpin:30176084"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02678">
        <property type="entry name" value="MIT_VPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19521">
        <property type="entry name" value="RecA-like_VPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000043">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000015">
        <property type="entry name" value="vacuolar protein sorting-associated protein 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.80:FF:000014">
        <property type="entry name" value="Vacuolar protein-sorting-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045253">
        <property type="entry name" value="VPS4_MIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF83">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIT" evidence="11">
        <location>
            <begin position="3"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="165"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="76"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC69823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="439" mass="48490" checksum="26E0F0EE5BA99C82" modified="2024-07-24" version="1">MSNSNFLDKAIALVQKAIDEDVKQNYAEAYKQYQDALDYFMMAMKYEKNDKLKELIRKKFTEYLDRAEKLKEHIAKSEEKRTKAKVGVNGGGGSTAGGPDVKGDGEGDDPEIKKLRQGLQGAILSESPNVQWDDVAGLAQAKEALKEAVILPIKFPQLFTGKRTPWRGILLYGPPGTGKSFLAKAVATEAKSTFFSVSSSDLVSKWMGESERLVKQLFQMAREQKPAIIFVDEIDSLTGTRGEGESEASRRIKTEFLVQMNGVGNEETGVLVLGATNIPWQLDPAIKRRFEKRIYIPLPDVQARRRMFELNVGTTPNGLTPRDFTNLAEQTDGYSGSDIAVIVRDALMQPVRKVLSATHFKEVLVQVESDGKTKLTPCSPGDPAAVEKSWTDVNSEELLEPLLSVKDFEKAISVNRPTVTQADITKHIEFTNEAGGEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L5P3</accession>
    <name>A0AAJ8L5P3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">I206_104009</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. GCN5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058970.1">
        <property type="nucleotide sequence ID" value="XM_070202869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L5P3"/>
    <dbReference type="GeneID" id="30172786"/>
    <dbReference type="KEGG" id="kpin:30172786"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010484">
        <property type="term" value="F:histone H3 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05509">
        <property type="entry name" value="Bromo_gcn5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037800">
        <property type="entry name" value="GCN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750">
        <property type="entry name" value="GH11602P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750:SF3">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="16">
        <location>
            <begin position="575"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="15">
        <location>
            <begin position="818"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="236"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="354"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="877"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="13"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="68"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="245"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="370"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="411"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="490"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="WWC70063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="909" mass="102626" checksum="34DE34226480F80C" modified="2024-07-24" version="1">MPRRKPASRNKGLSIATSTPAASSRATSADTRDSSSLSPAKSTAAISVGEDQEVQAEEEGSDANGVEEVPEEEDGDQDEDEEVEDDEEEGTVEVDVEDGEEEDDENEEVEEDEEDEDGDEDEDDEEDNDAEEEEEEDGNEDEDEDEDEDEDEDDDGGEGQDDVPIPQIEVSQAEEEDLLDEKIDLSCPPNLKFKYPKAVQDILKISDRERSFKIARFIKCQVPDCECEGLEPPPHHQIKLIGHDQDDEDEDEDDDEEGDGDVTMSEAMEERKRHWRTSKGWWRLCGNCNHGWQGEGHVWPKDVNSDERKRRAKTVGRIEELLQDDGLLVKFPTPRRENTVSLFKQLNHFIRPAGKSTTVPALPEPTDLTSPRESRSGKSPRVRDVSDGEMDVDGEDGERPRKRRKSGTAQSDEEDQVIDDDADLESAKPHKHGKKKPGKTAGKGREPRTVVRGTHGIVSMETDADGNQHVAGAEDSKEANEDEEDDEDVPLAKRPELDEQERKRRTEIKEKEKEKEEELMRRLTKGANVDDGSAGLGGGQAGIDVEIWEGVELPKLPLRPAAIEQQNKEIMLPVVSSREPTQVATILLIGLKNLFQRQLPKMPREYITRLVLDKNHISMAIVKRGWKVVGGICYRPFESRGFAEIVFCAVDSSEQIKGYGSHLMNSLKDHVRAAHPTINHFLTYADNYAVGYFKKQGFTKEISYPRERWVGYIKDYEGGTIMQCTMLPKVKYMDVHQMLADQKAAILAKIRTISRSHIVHPGLAIFKSAKPGDEIKLTKEQVPGLAESGWNPDLDDIIRQPKRNPHHVLLQLVLNDLQNEPSAWPFTKPVDGNVVVDYYEVIKDPMDLSTMEYKLENNHYESVEDFVADARLIFDNCRQYNGEKSTYTKQANQLEKALDKILKKRQSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L6L6</accession>
    <name>A0AAJ8L6L6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Chlorophyll synthesis pathway protein BchC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_104221</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059022.1">
        <property type="nucleotide sequence ID" value="XM_070202921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L6L6"/>
    <dbReference type="GeneID" id="30172570"/>
    <dbReference type="KEGG" id="kpin:30172570"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="10">
        <location>
            <begin position="44"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="9">
        <location>
            <begin position="202"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC70271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="392" mass="42288" checksum="1577B11CEF6FC139" modified="2024-07-24" version="1">MSAQAVLPKGSPHPAEFKPKDNPAFILHDKLKTGYEEQPIPEVGPDEVLIEIKKTGICGSDVHFYNTGAMGLVKLQEPMCLGHESSGIIVQLAVNSVVGKGTIQLGDKVALEPGVTCRMCTDCRGGCYQICEHMVFAAYPPSRGGTLQRYYKLPADLVYKLPESVGLEYGAMMEPLSVAVHAIANKGQLRTGYNVIIFGAGPVGLLAMGVAKGLGANRIVAVDINKERLQFAKRYAATDIYIPIKQNEGESRPQYSLRAAQDLLLTLGIPTRGPGSIDLVMDATGAEVCIQMGLNAVRPGGTYVQTGFGPPDIQIPLFRVTTEEITIKGGWRYGNGDYPLAIDLVNRGLVNLEPLLTHTFKFKDALEAFEITKAGKDKNGKFVIKCVIDGPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L6X9</accession>
    <name>A0AAJ8L6X9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alkyl transferase</fullName>
            <ecNumber evidence="4">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_104661</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059084.1">
        <property type="nucleotide sequence ID" value="XM_070202983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L6X9"/>
    <dbReference type="GeneID" id="30170568"/>
    <dbReference type="KEGG" id="kpin:30170568"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904423">
        <property type="term" value="C:dehydrodolichyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016094">
        <property type="term" value="P:polyprenol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1180.10:FF:000005">
        <property type="entry name" value="Alkyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291:SF43">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT DHDDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC70710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="304" mass="35094" checksum="3CA15E1704221C3E" modified="2024-07-24" version="1">MSITNQSFSPVKIKKSTILNEIVHFSFSIITSFLLYLISLGPIPQHIGFVMDGNRRYAKYLGKQVSEGHGEGFTALKRTLEICLRLRIRVVSVYAFAIDNFNRSEKEVSTLMRLAKDRLTELCQHGELLEEYGVKIKFIGQISLFPLDVQEAIKDMEEMTKNHKNGILNVCSPYSSRDEITSSIRQTIESINNNNNNDYNFDEELIIKKEKIKSNLLFNNLGTSKAISKVDNKLFKRPEENGKLDILVRTSNVKRLSDFMMWQASNDTQLHFVNTFWPEFGLSDMIPILLGWQQKQWMRQLGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L853</accession>
    <name>A0AAJ8L853_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_105913</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC71954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059309.1">
        <property type="nucleotide sequence ID" value="XM_070203208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L853"/>
    <dbReference type="GeneID" id="30173105"/>
    <dbReference type="KEGG" id="kpin:30173105"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF7">
        <property type="entry name" value="NMRA LIKE REDOX SENSOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="6"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC71954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="286" mass="32373" checksum="F77074E790BBA2D6" modified="2024-07-24" version="1">MSTIAQNIIVFGATGQQGASFIEALSTQNTLENVKYAIYALSRNPSSNQSTKLSNLPGVKVISVNKDYMNKPELAFEATGLKIDEIYGIFNVQGYVSDKVELAQGKAIIDASKKWNVKQFVYSSVSFGGLDDTKASGMEVKRDIENYLFESNLGYTILRPTQFMDNLLPNSAFIKHQLISIKDIGKTASQVIINSNKWLNKIIELAGDNLTIQEIENIYKEELNEPIELTYWPLATFVRWVSPLGPMAKFFDNYGFKVNINQLKKDLPEVEFEDFRTYLRRYKASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L8P3</accession>
    <name>A0AAJ8L8P3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_106186</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059368.1">
        <property type="nucleotide sequence ID" value="XM_070203267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L8P3"/>
    <dbReference type="GeneID" id="30173380"/>
    <dbReference type="KEGG" id="kpin:30173380"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="595"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="636"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="749"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="817"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="71"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="238"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="503"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="851"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="302"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="507"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="520"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="874"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC72224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="912" mass="100010" checksum="116D12D98916839F" modified="2024-07-24" version="1">MTSSHSQTDRSLLHPNPSPAPTSFSSTHNHHQQHTTSNPIIPHNQQHNYVPSFDDLGLSSQGITERALFSENNTPIPTPRFTSPAPPSFTPNQNHNDLSTSPHSDIVESSSIPEWRKASPKWLYPFIIGVPLCIGMSMAPKAELYVNLACLAHPPSASQDSTSHQYVVNSINRFEDFSKSGISYLSFVESQGLGRIQPIEDSNPTLGGIPTGGDYVLSPADKWFLKLQHDMYEYRLHHNGNSTKSPSSSKPINLPTFTTSYERPEPTSPLPRPDKPFPSNDDDKQKQTPYPSDDDDEDQGDDNDKDRDQDDKDHRPYQAIDPRLCKKDVKVQAAAAKLTMVMTLTMGLLSALTTGFWGKTSDKLGRTKVIAIVELGLLLNEICFIVVANFPYLIPGGYRALLLGPTIEGLLGGYSTISATLNAYVSDVTPDGSRVTIFARIGGMFMAGFALGPVLGSLLISWTGDIMTPFYVNAVVFAIYIPLILLMLPESLSNQARATLAKNASTAREEAKKRDQLEREWEDETPFPADGVDETDPLLSGWSRMSFATTGNGASKARKKTIGNFRRIFRRVFGFLEPLAIFIPVKKEGENRRDWNLTAVGAGLFFMSMVFGIMSIKAQYTFYAFGWTSAQLGPYMSITAFSRSFVLIVLVPIIMHFVKPRYQQDETSTSILAGHPTIDEEAFTNEVASTSAITTESNTASSSSLTNSSSDIMMKTKTKRSAHLDLLTVRVSLLLESIPYLLLSLSPPPIGFILLSIMTTLGGSGNPAANSLALSLLNDPSTQSGKLFGALSVLHALGANLISPLMFGTVFASTVGIYPATIFTIATCSLILAQICMSFIRLEPLIVSQKDNYNNNNKKNNERIRGRSRKIKRVNSSNLSNTSGNESGIQNIRNNSKNINKIGYGTMEENSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L9N2</accession>
    <name>A0AAJ8L9N2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_106095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="kpin:96955766"/>
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    </dbReference>
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        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
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        <location>
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            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC72135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="189" mass="20526" checksum="DBF7BB90682E4849" modified="2024-07-24" version="1">MADKKKDANKKGLKFGPFEQALLMLVVLGFAYIGYHVLTRQEAARGRTKALSKVKSSSSSSRSSSSSTSQKPLSSSDVRAGGMPSSSSSSSKRVGNPAPKQISGSSSKDDPSSTSFRKNYFLTMQGPGRPALVPFQDGLRPKKDAADLMAPPIDKEKLKAMMKNPWAGEMIEKDIQLLKIAKRQKEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LBE9</accession>
    <name>A0AAJ8LBE9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ARM repeat-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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            <taxon>Cryptococcaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144526">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059356.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LBE9"/>
    <dbReference type="GeneID" id="30173323"/>
    <dbReference type="KEGG" id="kpin:30173323"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040144">
        <property type="entry name" value="RAP1GDS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10957">
        <property type="entry name" value="RAP1 GTPASE-GDP DISSOCIATION STIMULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC72170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="454" mass="49798" checksum="3F3232C27F1DA4AE" modified="2024-07-24" version="1">MGSITDDTAENPTSEAKLVERLSALGAEENKREEIISILDTLTVALRNDLSGEEDDELLRQVGRVAANLVIDCDANRNILVKAGYVDSILSHPIFQLPARSAPASAVLAITASLHNLTVDKNELHLRTIIDFTHRWTEDFYSSSPLDETITIARWAWSIMASILEDPPSSLPFNTISTLLLPISSHAFDSNIDIDSHLHILTHSCNTLDSCITQANSSRTDLLEHLGSLTDFVEKADVPNQTEVEDEGEDQEDDDEEDFEKRLGKAKAATVRGLVDLSTDVPITSSFWNTMRRWLDIKERSDLLNCALLTFGNSVKDGLMKNLSVARDNQDVLGKAGVIEKLYEMGVWSEKTDMLGSVQGGAAGIVKNLCRSNGDARIIDALAKMLVDGEKYPVLQSESVIALTLLATFGGEDINAAVELSLEGKGGDIIRKMGEDPRKEIRENANTLLKAIQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LBG5</accession>
    <name>A0AAJ8LBG5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_107075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
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            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC73110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009820.2">
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    </dbReference>
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    <dbReference type="GeneID" id="30173750"/>
    <dbReference type="KEGG" id="kpin:30173750"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="356"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC73110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="377" mass="43041" checksum="E377E8F8475E5586" modified="2024-07-24" version="1">MASCLPGNIRFTLLSASLLCVTSYLLHNHKHHHIPYQFLLNLVNLISIIAYVPLLSARLYEYVRPLEFLLVLTIFQLAATCGFLALSFLSIYTLYSFPTMTSTSNTPDVTSPPRTAQPLFMLVRLDMNDFYPHLLQLVHISILAIQLMASLLLIIEIRGSPRYSMIDKSLAGLLEKDINDLIKLRQDIRYLKTPTVRWNERHSIGHSTFTDWSPHKRTLDETGEGTPRRRSRTSSNNTSLITPSAPSKQNIDLEIETNHNKDKGYEFNNQDNIRRSSKNNRRLSVRFDLSRHLEETISPRTELFVNPALQDYFSLPITTSEVTRPIPLSIVNSSKEANGFSPCSNGSETLEDILEEEHDHSEQKDNAWMDVRGEESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LC22</accession>
    <name>A0AAJ8LC22_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Solute carrier family 25 (Mitochondrial iron transporter), member 28/37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_107362</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="kpin:30174057"/>
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        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048250">
        <property type="term" value="P:iron import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000172">
        <property type="entry name" value="MC family mitochondrial carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758:SF4">
        <property type="entry name" value="MITOFERRIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758">
        <property type="entry name" value="MITOFERRIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="56"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="183"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="274"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC73395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="39741" checksum="FE27CBD73B2A98D0" modified="2024-07-24" version="1">MSSSTSSSSSSTTQFHIHPHSAHLTGSVPPIQPAGESSVALEEEEEHDYESLPVGSGWAVNMAAGAMAGISEHAAIFPVDSIKTRMQVLPALNPILSPLGASSATASASSSAAATATAGVRPSPPQLNTIMQHVRSISTTEGLRSLWRGVASVILGAGPAHAAHFGMYEFIREISGGRGEGWSGVAGTALAGAAATISSDALMNPFDVIKQRMQIRNSPHRTVLSCAKTVYAREGLAAFYVSYPTTLTMSVPFTAVQFTAYESLKTLLNPDGSYSPITHCTAGGIAGGLAAAVTTPLDVAKTLLQTRGSNSDPRIRAARSMGEALRIIKDRDGWRGLRRGMLPRVLTVAPSTAISWMSYEFFKVLIRQNGHLPESGQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LCC0</accession>
    <name>A0AAJ8LCC0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_107545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059643.1">
        <property type="nucleotide sequence ID" value="XM_070203542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LCC0"/>
    <dbReference type="GeneID" id="30174242"/>
    <dbReference type="KEGG" id="kpin:30174242"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044851">
        <property type="entry name" value="Wax_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595:SF57">
        <property type="entry name" value="OS04G0481900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="488"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="354"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC73573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="62582" checksum="7150F6EE9625083C" modified="2024-07-24" version="1">MGYIQIPLYELVSRLPTPHPQNGLDVFIGLATVHLMILTHLTPHTGGWRLFRMGIIAPLCLTGFGYIVVGQIEKDDLTHWGTCVLMCIYSMRVLEYFVFFPAEENCHRIVPRSQIHPRAKSTHLMTPESNGHSDQSSPSNIQAGELEDDEVLIAEPVPAPFTLKKLYWSWSLIWSYRGIGWNYQCPLPSESTNHPFSRKSSRLSWGYATIRYYIIGYLIDDFFRSIRNIYGKEFFAGNIPYNTLNQFERGLYSTAVVIRVWFGLIHSWTISAIIFVTLGGILGWNDEIFAPWGWPPMFGSLNQLWKHPGLSTMWSKTWHGYNRRWLYVLGWIGIGENVLGLTHTGISSHPNMPPSEKSSNSSNTSGQISPSHPIPTSSPSSSSSTNQKVNLPTRKISNRLMIENLIKSFITFLLSGFNHDVGSFALILKNNPPAQSQIKTSIYLTDIFKLTPFFVIQPIGLILEAIFKINYRKFKIYYLGISKGKESSLLIFFERLFGFIWTWVWLGWTARFFVQGMIQLGAYRRDGDRDLYWNLFGGLIWGKWYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LCW9</accession>
    <name>A0AAJ8LCW9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_107832</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009516.2">
        <property type="nucleotide sequence ID" value="XM_019157876.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LCW9"/>
    <dbReference type="GeneID" id="30174534"/>
    <dbReference type="KEGG" id="kpin:30174534"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF12">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="61"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC73860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="160" mass="18639" checksum="2349BEAECBE4330F" modified="2024-07-24" version="1">MHYISTVYYRIQSRYGFLDWLSIQNWQFKHRYLCALQPLSDINIEQQDDIARAIDEHFGAFFLWMLYGLGAKLCENDPGIIPVSHEVYFDTALRHFTPLSTIQSLTTVQALLLLIVYTFRHTSSELSLWHTGGLAIRSAIELGLHRKIRLKDIRESDPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MMN2</accession>
    <name>A0AAJ8MMN2_9TREE</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_101141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="412"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="726"/>
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    </feature>
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            <end position="923"/>
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    </feature>
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            <end position="1059"/>
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            <begin position="414"/>
            <end position="428"/>
        </location>
    </feature>
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            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        </location>
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            <begin position="1026"/>
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        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MNL8</accession>
    <name>A0AAJ8MNL8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BIR-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_101922</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="kpin:30175356"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Unplaced genomic scaffold supercont1.2, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Baculoviral_IAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46771">
        <property type="entry name" value="DETERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46771:SF5">
        <property type="entry name" value="DETERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="210"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
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            <end position="310"/>
        </location>
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        </location>
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        </location>
    </feature>
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        </location>
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        <location>
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    </feature>
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            <end position="450"/>
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    </feature>
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        <location>
            <begin position="463"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MNM6</accession>
    <name>A0AAJ8MNM6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Solute carrier family 25 (Peroxisomal adenine nucleotide transporter), member 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_104103</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059000.1">
        <property type="nucleotide sequence ID" value="XM_070202899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MNM6"/>
    <dbReference type="GeneID" id="30172690"/>
    <dbReference type="KEGG" id="kpin:30172690"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF2">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G13870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="5"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="134"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="239"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC70156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="37315" checksum="2D51338503896406" modified="2024-07-24" version="1">MNTTLPPFLQATSGALGSAVGNALVYPLDVATTRMQNNARKPHYERLNLRDTLSHLLSQKNYLSNLYSGIEADTLSTLLSNFIYFYTYTSLQKGLHIWYLKHPILPNKSIKSSPAGIGGLSSKASDSLPKINKPNPIEELLIGIISGLISKGISLPISTICVRKQIENDFENDNNDETKKKKSSLLDSLNSIYNEQGIEGLFSGFKPTIPLTLLPSLTLYIHSLLVRLILPSKYHKNPPPAAITFLLGALSNALATLPLYPLVLIKVLSQSGREKGKDSKKVGILETLIRIIRRGGIRTLYTGLEGQLFKGFVQQGVMMLVKQRVEQGVVKAYRARSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MNV3</accession>
    <name>A0AAJ8MNV3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sister chromatid cohesion protein PDS5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_101891</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058571.1">
        <property type="nucleotide sequence ID" value="XM_070202470.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30175387"/>
    <dbReference type="KEGG" id="kpin:30175387"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19953">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039776">
        <property type="entry name" value="Pds5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663">
        <property type="entry name" value="ANDROGEN INDUCED INHIBITOR OF PROLIFERATION AS3 / PDS5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663:SF0">
        <property type="entry name" value="PRECOCIOUS DISSOCIATION OF SISTERS 5, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20168">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1164"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1168"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1213"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1255"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1279"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1294"/>
            <end position="1303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC67972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1303" mass="146180" checksum="5DA0BC660BB71C14" modified="2024-07-24" version="1">MTRASQTQSLAKLDFSEPLIQSGKRENTEALLKRIKTLHQKLSTLEQDAVDIKSLDPIRKPLIKDVILHHKDRGVKAYAACCLADLLRLYAPDAPYSESQLRDIFNFFLVQLTSNLKLTTSSTQPLQISRNKSNIINQPSQPSQTTGQRVTDIPYYSEYYHLVESLATIKSVVLVCDVPDSDMLMEGFFNGFMEIVRPDMNKTLIRYLRDILVALIEEASQLPQGVMDCLISQFENYASRPEVLSFQLTVDVCNQVADKLKRPIYAHFSEIQANHGRDPSPDDIKALTESHALLITIYKFCPDLLLNVIPLLEDNLKVSDELIIRQLSVKTLGRLFAQRAGSEDPSKKYPSTWRAWLGRRVDKAFNVRLTWVEGTKGVLTNHPEVREELQSSLRDRIHDSDERIRAAICKIVGSLDYETALHHISLDTLKEIAGRMSDKKASVRSESTSALAKLWNLAYSEIESSNPDAIKQFAWIPEAMLLATCNSIVTLEMRMQLTSIFKTTILPLPKETDDEQAWVDRLLFVTSRLNDDAFVALRKIIGLAEYAKGNSPFMAFVLFCEDYNGGVIADGSQDAKLKLNFVIDAIARSYFGDAEKAKKDLNAFAAANEARLFKLYKTCIDIQSSLASIVKAKNELLRKVHQSHDDLLETITSLVNISTWNIVNQSSIPPLLKRISKPESEASSTPALRVLGILAKEGAPLFKHHAAQLVVAMMDRKNDHLVELALQAMGAVCKIYPEVAPAEHRPIERAINIALEGTPRQAKFAARFLARSKEPDACESLVTEIVKEFKKEDQKHLLTHLRALTELALIKPRVVEAQSEEIMDFIMAQVINSPSPSTDVGEDDKWVEEDSLEPLDRAKISSLKFLTHRTLGFARDPEADTILRPVLKLLSDVLFNDGKINENTQEGGAVRCHLRLKSSVCLLKLANVRTFDKAIAEQCQFDLVVGAVQDPCYMVRHLYLRKLGKVVPTQRLSPQWNIAPILIAMDPEDENKQAGLRIMQKIVATCSNLSTADKIERTEMPLARLLHFLAHQPDVHWAKAEQGEEIIGDQQNLHDVARFIEMYLDCVAHRDNVGLLFAIAQGLKGLRDRSAESSVPLWILSELAVIIIRNRADKNAWPIPIYPGKIRFPKDIFHHADNHEEKSKVQHTQYLTQEVREWAKTLGRRNVNVASAPTAQKKAQSGNNHTRSPPTSAKRKAATSGNKKSSKKIRIEESDDDEEDDNEEDSDDEDNGDDEDESEEGEEEGDDDEGVLGRGGKRGAKTKAKRAVSGKKAKKVKVKKSDKSVDDGDKSEESDLTDLSDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MP63</accession>
    <name>A0AAJ8MP63_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein sorting-associated protein 54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_102503</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS54 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058672.1">
        <property type="nucleotide sequence ID" value="XM_070202571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MP63"/>
    <dbReference type="GeneID" id="30171223"/>
    <dbReference type="KEGG" id="kpin:30171223"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039745">
        <property type="entry name" value="Vps54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012501">
        <property type="entry name" value="Vps54_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019515">
        <property type="entry name" value="VPS54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07928">
        <property type="entry name" value="Vps54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10475">
        <property type="entry name" value="Vps54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 N-terminal" evidence="11">
        <location>
            <begin position="180"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 C-terminal" evidence="10">
        <location>
            <begin position="691"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="935"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="254"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="965"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="983"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1073"/>
            <end position="1084"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC68573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1092" mass="119903" checksum="3023691BD9342E72" modified="2024-07-24" version="1">MSQPPTSAPTPVPSSPPAPSESFLSDLDGTAPSILDTSFGDPSYDLGRFDGGALNLVSWKLDVNARNEDGVEKRGFNAISTVLNHPTKKADPLRSTRKPLPPLPFTPPVIPKPPPASHYDGYLQTITPLYDNFISLSQKASSSSSTSAGLDRIKSPSSSEFTSTDFPSSSVFTPNDLPTLDSIPSMFFEKDFNLSNPATWSEIISSPSASSSAVEAPNEGLQDTLSSHLDLLERHLVVEISKRTNSFFGALTNLQELNTESSSCLNRIDELKESLKEINEKQSKKGLTLISKQDDLHTLKITQKNLDHLKELDELLIVLKRLVGEGDWSNSLSYLEDIIKWYNRYSITVKTESEGSSSNLPLSTLPALASLPATLENHLNTIAIQLESALSSFLSTTLANETSEFDHSSFASTIEPILVGLVRCGKLELVEDVWRDNVIVCIREGSRNHLPIGQEDEDGTDKPPEARGASLAQSLQAMDHSSFLLLSTQMYASLTSRIKLAQSVGEKIDRILKSITSVPKLSISPSLLSTPIAESSSETPLPNLQEAITSGCELAHTRASKILAVRAEQHASLGLEEFVEIFRENWEFILATEKIAGKMIVGLRGVTTSQARSFLVSYHSVRLTKSAKLVEEEQWTQIDVPSDVQHVINLLIQSAVSDPPECTIPPPAANGESSNSAITVGMKKQVDVEDKSYFLVKATSESLVLLGDYLKIVVNLELVVTDVMSRIIEFLKSFNSRTCQVVLGAGAMRSAGLKNITAKHLALASQSLSIIISLIPYIREFVRRHLSPKQAVMLTEFDKLKRDYQEHQNEIHAKLVAIMSDRLAVHVGSLREIDWEATPNRDAPRPYAEMLVKETATLHKVLSKYLAASTVDSVMSEVITAIVHRLSEEYSKIEFKSEEAKKRMLQDVALLIIKLTPLSESGKEVNKLETLVKEKPTPRKPIGQAMSGFLRRNGSQKSESGSPIVEDEIEVEEKEEDEEEGDGLIKGKAAREDEGQGGDKVEEAANEKEEAKIDNVENIKLPALNQDEITDKVEEEESTNHEVEKGLPAVQKDPINSQSEIPDKELPVPPSKSTEDVKSPEKDSPPPPTPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MPE5</accession>
    <name>A0AAJ8MPE5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_102763</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058721.1">
        <property type="nucleotide sequence ID" value="XM_070202620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MPE5"/>
    <dbReference type="GeneID" id="30171487"/>
    <dbReference type="KEGG" id="kpin:30171487"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF233">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="510"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="444"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="833"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="939"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="126"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="179"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="254"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="279"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="372"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="387"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="833"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="844"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="856"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="878"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="891"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="975"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1019"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1042"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="539"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC68828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1056" mass="117284" checksum="465898B5BD7330EE" modified="2024-07-24" version="1">MPSSSYHKYRQSDPEDGELLEDVRQFSHKSSLPSRPPPPKIIRPPKPATTSTNQSWTNPLDNAGPSKPRISTSPIRSLNKLPPAPLTASTSSSSYKSTSPTRSIDSKSFHGLPSKPSVVGISTNQKGKEPDHHRREINDLHERKYSDKPPTHEGRSGEYDNAPLRHHSLGHVTNKSPSRHRDVENSWRAESGRDNRYRPDSREDRYRPDERDDRHRIDDRDRYERDRLRGGRHSHYANEISEDGYSSARGTHSSRREEFVKERGHSKEYDQYQGYVSPPRKRPASPKPHWKHEREHIDYKHRTDHKDRNGRDVRIGEDGGNPKGSTMSPAKKDKELMGTTESQDRKKSQTAPPATPPLPVSPALDLEEGESQPHNPHSRGASSYNGPMPPRDPPPPPPPPEVEMAPPGTPPPPPPDTPPPPPVPSTEQTPAQVDVEEKAITMNPYAPKPIPHAPNRNLLDPPTRANTPTTKKDTGNPYEPSTYRFRTLTAEEELRKLGKTFEGTTTLAAYDLGAKLGEGTFGVVTKGIEIATKRAIALKKLITHNPRDGVSVTTVREIKILKSLNHENVVPILNMVVERKVPGDRSSRGEVFMVFPYMDHDLCGLLGNKDFKMTHSMAKLLMQQILQGMAYIHANNFIHRDIKTANILVDKHGQIKIADFGLARTWTHDALMPPHLANEYTNMVVTRWYRAPELLLGDTHYGPSVDMWSLGCVLGEMYFRHPILAGDSDRDQLYQIFSRVGQLSQESFPNWDRLPGFPEAIGHPWDKTPVDITLLDSAPKWGMDRGGADLMIKLLMLDPKKRITAHAALDHEWFWVSPLPADPIKTTINVDSSHEMTTRQKQEPVVAPAQVRPAPSRQSHQHAFNNVQSRPPPPSYAQSRPQQSFQNQQQHGYNNFPQSGYQPGFQSQPSMQNGMPFGGGGPPMGMGMNVNMSMGTGMPIQPGFNGGPASFGGPASFGGPASFGGPASFGRPPSNFKQQPQQNRSNGLPSAPFKLSGQGGLPAAPFKLSARPTGGMGRPQNQGYNGNSVKRGPPTNGTGNGWRDEKRHKADEGLPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MPG7</accession>
    <name>A0AAJ8MPG7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aldose 1-epimerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_103000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldose epimerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058766.1">
        <property type="nucleotide sequence ID" value="XM_070202665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MPG7"/>
    <dbReference type="GeneID" id="30170364"/>
    <dbReference type="KEGG" id="kpin:30170364"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09019">
        <property type="entry name" value="galactose_mutarotase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047215">
        <property type="entry name" value="Galactose_mutarotase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF6">
        <property type="entry name" value="1-EPIMERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042590152" description="Aldose 1-epimerase" evidence="4">
        <location>
            <begin position="21"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC69064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="381" mass="41747" checksum="BC33C36668A70FBF" modified="2024-07-24" version="1">MKLLSSLLTVFATGATLALANNDALQPYTIYAYGINATFIPYGARLTSLYVHDKNNTPRDVVVGYDDPAQYVKDTATNHTYFGAIVGRYANRIKNGTFTVGEAEYHVPTNEHDGENTLHGGTMGYDARNWTLTQYNTSSVTFTLLDASGEQGFPGAVLTHVTYTVTSPPRLTTRIVSVSLDDYTPIMLSTHIYWNLGAFQSPTILNDTLYMPYADRIIDIDPILVPTGGLSSVKYPWQSPSVPLNFTSPKQIYEGALYSQQCGEGCTAIDNAFILDRPPYSSPEDASGPVLQLTSADTGITLTLRTNQQSLQIYSCGGQNGTIPVKASQGHGYVEKYGCLVIEPQQWIDGINQPEWGQMDRQIFGPDSPPQVLWAAYDFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MR57</accession>
    <name>A0AAJ8MR57_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">40S ribosomal protein S28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_104579</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059076.1">
        <property type="nucleotide sequence ID" value="XM_070202975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MR57"/>
    <dbReference type="GeneID" id="96955748"/>
    <dbReference type="KEGG" id="kpin:96955748"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04457">
        <property type="entry name" value="S1_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000025">
        <property type="entry name" value="40S ribosomal protein S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000289">
        <property type="entry name" value="Ribosomal_eS28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01200">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC70628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="66" mass="7406" checksum="9FCE4D790D672973" modified="2024-07-24" version="1">MESTNKQPVKLARVLKVLGRTGSRGGVTQVRVEFMDESNRSIIRNVKGPVRVNDILALLESEREAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MR92</accession>
    <name>A0AAJ8MR92_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FCP1 homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_104684</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012727.2">
        <property type="nucleotide sequence ID" value="XM_019153987.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MR92"/>
    <dbReference type="GeneID" id="30170591"/>
    <dbReference type="KEGG" id="kpin:30170591"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000270">
        <property type="entry name" value="Nuclear envelope-endoplasmic reticulum network protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="411"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="309"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="333"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC70733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="620" mass="68929" checksum="01D5A7F05EC08977" modified="2024-07-24" version="1">MNTLSRLDSYVFSFFTFPSRSPSSSKIPLPRNVTPPPIPSSSTSSSSSSSIPLLNPNSSPRLSNLPPTPRPKSRRRPTPSIHRRKKGIITTYSSIKVPPPTTPILLRIALVLWSILLSFWTSLVGETRSGRSRTRKIRKNKSTSNGVGVLRELGESLMVSAGISESNNQLQLQQKQQQQQKHKRLSTISNEIEGSGSEIERELENSLNETSDEDEEDENWIDPLVTRAPSNQDSLEQSPPSDNDFTSTITTTIEDDEKRNKDHANFSFRLKSAQSKTSDLHIIDPSPPDTIRRKSSTLTSFRRQPSPPSILSNPIPKLSIPTITQVEEENEDSLTPVSSKTPTSTVGKKSSILANPISTSILDPTVPAPIKKNDSSIFRKTNLMSSTLSTTTTTTTGSINTRIPRSISTTPFHLQKTLILDLDETLIHSTSRPLKSLNGNGFSSSGGGGILGLSLNGFNSGNKFNRSNREGHCVEVVLNGRSTMYHVYKRPYVDHFLKKVAQWYTLVIFTASMPEYADPVIDWLDSGKNLFSKRFYRESCHLQLNGSYIKDLSLVEKDLSRICFMDNSPISYNWNKANALPIEGWTSDPNDEALLQSIPVLDSLRFVNDVRRVLGIRGFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MS82</accession>
    <name>A0AAJ8MS82_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cystathionine beta-synthase</fullName>
            <ecNumber evidence="4">4.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_106493</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-homocysteine + L-serine = L,L-cystathionine + H2O</text>
            <dbReference type="Rhea" id="RHEA:10112"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="4.2.1.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.22" evidence="4"/>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059427.1">
        <property type="nucleotide sequence ID" value="XM_070203326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MS82"/>
    <dbReference type="GeneID" id="30175667"/>
    <dbReference type="KEGG" id="kpin:30175667"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004122">
        <property type="term" value="F:cystathionine beta-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000003">
        <property type="entry name" value="Cystathionine beta-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000118">
        <property type="entry name" value="Related to CYS4-cystathionine beta-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="7">
        <location>
            <begin position="20"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC72531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="397" mass="42587" checksum="09FC674B97B4E29B" modified="2024-07-24" version="1">MGGDTKSHHHWQGVLNSALDAVGHTPLIKLDRIAKAEGLKCNLLGKCEFFSAGGSVKDRIAKRMVEHAEKEGVLIPGQSIVIEPTSGNTGIGLALACAIKGYQCIITLPAKMSLEKEVMLRALGAEIVRTPTEAAWDSPESHIGVARKLQKSIPGGVILDQYSNPNNPLAHYYTTHEEIMYALKTSDLPRKDISLLVAGAGTGGTITGLGRAIRDYESSLVNGAASSHSRTTILAVDPEGSILGGGEPGNYQVEGIGYDFFPEVLDPNPPVVDQWIKTNDEEAFAATKRLIREEGLFVGGSSGSAVSGTLRYLHSAEGKVISEDEKANVVIILPDGVRNYMSKPWFLETSKKAINENVGEKEDIKVTIKGILGRDLNDVSKVVHDAKENGKKLENGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MSL7</accession>
    <name>A0AAJ8MSL7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Class E vacuolar protein-sorting machinery protein HSE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Class E vacuolar protein-sorting machinery protein hse1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I206_106900</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the STAM family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC72936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059526.1">
        <property type="nucleotide sequence ID" value="XM_070203425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MSL7"/>
    <dbReference type="GeneID" id="30173924"/>
    <dbReference type="KEGG" id="kpin:30173924"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16978">
        <property type="entry name" value="VHS_HSE1"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ENTH_VHS"/>
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        <property type="entry name" value="SH3-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR001452">
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        <property type="entry name" value="STAM"/>
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        <property type="entry name" value="UIM_dom"/>
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    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF3">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00018">
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        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00790">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
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    <dbReference type="SMART" id="SM00288">
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="SH3"/>
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        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="13">
        <location>
            <begin position="16"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="246"/>
            <end position="305"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="176"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="402"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="363"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="419"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="488"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="511"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="576"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="597"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009666"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017923"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
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            <dbReference type="ARBA" id="ARBA00018978"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022927"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50179"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC72936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="638" mass="70309" checksum="E8CFB55825C6BBF2" modified="2024-07-24" version="1">MFSTTTNPYDEIIVKATDENLASEDWALNLDVCDKVSGEGESGARQAVASLTKRLSHRNPNVQLYALELANTLVQNCGKELYGELSSRGWTGALDRLVNDRTTAAPVKRKALTYIKSWAKQFEETGDPNLGIMGELYDQLRAKNFNFDEAEPQNTEDTAEARQRLEDEQLQRALEISKQDKGGRPNYSYQPSHPTAGGSSSSATNNTLVGGSSSSSRPAYQSSQSQQPVYSAPIPEPEPEQPLDINNATRVRALYTFTSAEVGELNFERGDVIKVLDRGFKEWWRGACNGKIGIFPVTYVEAVPEPSPRELQEEAQEEARVFASLGLVDQLLQTLKGIDPSRGDRIDDRPEIEEMYQASVGLQEQINALIKKYSDQKAELEHMNANFLRAIRQYEDLRNPAPPPAAYGYAPQQSPPADPYAQGGYQQYPQQPQPQQQAYPQQPPYAQQQQQIPQQYGAEPQHPPQQYASEPPHPPSGYYDQSPNGHIPQQAFPQAQAAPSTVPVGEPQLGQYYQQRAVSSSSVNRLPPSNAATAAGLNLPPTEPIRQNTEPGVAGLGAGSDPQAEHKKAWDDYYASQAQNQLPHPQNLGQQGGYNPQQAQTQQVDNTQSAYGQSPYPPQQGQVDNAAQDFSRMSLRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HTY2</accession>
    <name>A0A1B9HTY2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_07114</name>
        <name evidence="12" type="ORF">I206_106312</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894015">
        <property type="protein sequence ID" value="OCF46727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007946.1">
        <property type="nucleotide sequence ID" value="XM_019158808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HTY2"/>
    <dbReference type="STRING" id="1296096.A0A1B9HTY2"/>
    <dbReference type="GeneID" id="30175483"/>
    <dbReference type="KEGG" id="kpin:30175483"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000117">
        <property type="entry name" value="MFS hexose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="464"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="37"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCF46727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC72350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="560" mass="61927" checksum="A3B6F0078124E521" modified="2016-11-02" version="1">MEHAVHEPNASNADLEEIMKNRDTRWYRGYLGKLNLICLLCIITSMNNGYDGSMMNGLQSLNTWKDYFGTPTGSTLGIFNAIQSIGGIAGLPFAPFLNDRFGRRWTMFIGAAIQCVGVALQTGAQSVGMFIGCRFLIGFGLAFSCLAAPTLLTELAFPTHRGPITSLYNSTWYLGSIIAAWTTYGTFRIPNTWGWRIPSLLQGLPSIVQLALLFFIPESPRWLVDHGKDEQAIRVLTKYHCGGNTEDPLIAFEYNEIREALRLEKAANKSSTYLSLFRGRGNLKRMRVIIAIAFFSQWSGNGIVSYYLNLALDGIGIRSSGQQLIINGVLQVYNLATAYLGALLVDKLGRRPLWLISVAGMTASYTLWTICNGIYAKSATNLDADGNPIGANLAAGHGVIAAIFLYYASYNLAMSPLLVSYTVEILPFRIRSKGLMVMQMSVNASLVFNQYVNPIALGKLGWKLYIVYTCWLAFEFVYLYFTVIETKGKNGPLPLEEIAALFDGTEAKDEVQAATHNQAIVQPDHGLGSDYDEKAMQSKDIPVHQEHQELQTAPALSRDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HTZ9</accession>
    <name>A0A1B9HTZ9_9TREE</name>
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        <recommendedName>
            <fullName evidence="5">Acetylornithine deacetylase</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_07133</name>
        <name evidence="3" type="ORF">I206_106331</name>
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            <taxon>Fungi</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">CBS 10737</strain>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
    <reference evidence="3" key="4">
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            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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</entry>
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    <name>A0A1B9HU25_9TREE</name>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Murphy C."/>
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                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">CBS 10737</strain>
        </source>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Murphy C."/>
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                <person name="Shea T."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
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    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="595"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="720"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="749"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1419"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1609"/>
            <end position="1619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1620"/>
            <end position="1633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1651"/>
            <end position="1663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1671"/>
            <end position="1683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1684"/>
            <end position="1701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1702"/>
            <end position="1723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF46769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC72392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1812" mass="199923" checksum="DBE6D1421BD3A2E1" modified="2016-11-02" version="1">MSTPNQGNSASPAPQNLGYPFIANQQAGGMNYLPPNQQQQFMPNMDMSTSSPIPGASGGQGDPGPSSMAQQQQGQFRPQFQQQGGITPQQMAMLQQFSQAAQSQGGQQRQLTPQQVQMAMTAMQAQQQGGGSMNPQALMAAMRATQQNQGMQGQMSQQGQMNMQGQQQQPRPPNQQMNNFGGNQTQQPGQQTPNSAQMAYQQQQRIQQMMQARPNPGSPIRPHQQQQPNSMPPPPVPNSSQQPQQQQQQQSGNYIQQHNPGPSPQIASSPQGGFHLSQEQRDFLTQQRNNLYANPQFLAMPPQQQQAIMVNQQQQLIRTMTAGQIPQQSQQSNQQQQRQSQQGIPQPPTPSGRPSSSHGTPGPSQSPIIPRQPTPQQMGTPQAQQVHTPQSSHIQTPQQPLSSLPQHMAPPRPASAASQRAPSPHHGVSGIPNSPVVMQPTNTPPPSNGMFPSGNQQMGNASSPTPSNVSHHSQHQTPAPHHIQPPPHSVSPVHGRSQTPIQPQQVNTPQSAQSMNQVGMNGQYQPNQQFQMQPHQQVMATPQQGPQSFSQEYSGQARSSASPAQQGSYPVQPIVPNLQNMTAAQQQQMASAMSFMSQAAQAQQGSAPNTAQQQQQPQPQQQVRPLQQQGQARPPSMQMPNINTSDFPFDPRLLPLIQHVSDEKWRTAMMAQNPQMVVAAQQAAQILPTLRHDVIQRMQNVLYHTAKLQAAQGIRPQMPGQIQSDQSIPAFSPTNNQQISTPGAIPPNQQQRIWQAQQAAQGSPVSVNGASPAMRPPPPHLPPVSNMPGSPSTQRNALDRRSSQSNNKDVSVKSEKTPQQASMPPPAFIPSHTAPSTAGPSKAPDTSVPPSQPGSVALATKATPQSLPVKEWQNALRLDLPITNISALPINEIEEGEDPTFNGSLPPLSEWEKSNIQGWLEKDKKFVGYERENQAKRILKMKKWAEENDKATPWWMLRKGEARTKPTQRLRILWPTDKEKDRANRTHRGRKQIKFTPAQFKSMAEVEDQLVPVRLDLEHDNFRLKDTFMWNCSDKVVTPELFAQSLCDDFQVPPQHFFSRIVATIQERVKEYQDQVLPIIQRHPREEQRGKLDPEGDANQRAMYEIFRKIREGSGIGQEEEEIKTDPGEINDDVRIVSFDQNGPGSGFEDGAEETVPVEPLNDSEGRKPEIIDDEQVIKPEIVEEDRPMTVEEVMQLLPKEQTEELRILIKIDIIIGTQNLSDSFEWDLNSTVTPEEFSASYVTELGLSKEFATALAHDIHEQILVHNRSLFLVGHAFGSGLILDDEVRLAFLPPVTTSLRKEDLAMSSYTPIFNELAEDQLALVEAQREKESKRKKRTGRARRGVILPDRDPVKTQRSLLNPLGANGLPVFSAPELIAKDSLGGLTSRRRGAAIAAEANMALIAQDLPITGPSSPAHNHTHHHGPTISARGKRIGRPPKNAQRDLPRAGASPANFPGYDSQPGAGGLLTPQLHHGIKRSFREDSMDDLSTATGSPAISRKRANHSRIPDSPSQEPDTPVKQDFATLSHNGVTHIPYQNELTAIKEEKKPWHCRNCGVPEHLSGGPRKDKNGQKVLCGNCSRYLVRTGKDRPCDYTTDEAYHLEISRRLSLSQSQSQIRADSTTPTLVSPNKQPDQKLLNEPSSESSESSSSDDDDDDEDESDSTFASSGKSKKGPGRGRSRKSQSTITSSQVQVQAQQPQETPRNVSSTSQHSPNIAISPTSGKKVHVEMPVWASRALAEMRSKYPRDDFTVLQKPRPADIVGPIEWRAKCMDCPGRIYSLGPGETLLNFEVHLKNRAHIQNRLNREGKTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HUI6</accession>
    <name>A0A1B9HUI6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_07310</name>
        <name evidence="12" type="ORF">I206_106505</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KI894015">
        <property type="protein sequence ID" value="OCF46923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008142.1">
        <property type="nucleotide sequence ID" value="XM_019159004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HUI6"/>
    <dbReference type="STRING" id="1296096.A0A1B9HUI6"/>
    <dbReference type="GeneID" id="30175679"/>
    <dbReference type="KEGG" id="kpin:30175679"/>
    <dbReference type="OrthoDB" id="10020333at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14019">
        <property type="entry name" value="STKc_Cdc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045216">
        <property type="entry name" value="CK2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="383"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="121"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="236"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCF46923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC72543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="915" mass="102793" checksum="211AD91B2300A832" modified="2016-11-02" version="1">MDSTTSASTSSHSTSRITTWPLETLSTGASSSSSRPFHLNIPSRNTSITTSIASRGVKRQITGDRERLKSISPKRKRVNRELTPIDDSTPTLAENGEGISSFQFLNASGPASNYPTTAIAGSSSYAQEQDQIEEASENDESKSVLFSEQAGNGKNRYAEEIADNEGELDEKEEEGDETILVPEEQFVEEVFMLEEDNQEETRDVQEEILVEQMDDFDPHDGLLNMNEDVLTKSRPVTVNLRNVMPPPKDVRSHTKSKSTSSTSASGSGPNTIMKTNNLKSRPDTMTQVIEGSSSKKRQTQKQSFVELNQAAHSDNIEYDEDGLRGEEEEEDSISPESYHSGDSDNYEMEHRPILERTAIKKDIRNFTESLTVLRDGVDGYLPFKVVDRLGEGTFSSVYLAHDCLNRTYANEYWSGIPDEEDQDLEQAQPEVKVALKKILATSSPARIENELAILEALRGCRNVSQLISAFREEDQVIIVLPYHRSDDFRHFYRHMDPPHIRSYLQSLFRALKDIHKRGIVHRDVKPANFLYDYETGQGVLVDFGLAERYTPPRRPTCQHAPGTLVSLQGSKVKTSETSIVEQAVYDARKRSRQGEGRIGFPHEDKRPAIKTNRAGTRGFRAPEVLLKCPDQTVALDSWSVGVMLLSILTHKFPVFNSSDDIEALMEIAAIFGRAAMERCALLHNRTIMTNVPTVDSHPSSLASLVVNLNPHIYTPHMTNPTTEDARRHIEAIDQAIDLCQKLLRLDATKRLSAAQALRHPFLAAHDGEEDEEEGRDEVLEPKEGKCGELHEIVDGRHRTYLHPDMRDLAFGQGIPPTRDSLCPEHEHYQERFQINPLVTSRWVNQAAEDDSQADQEEDEMEDGEGDFIVEQPTINLRRYSNSYGHGDRLLKERDMNALTTQNGHNLIGKRRGGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HUM5</accession>
    <name>A0A1B9HUM5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin heavy chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_06744</name>
        <name evidence="11" type="ORF">I206_102161</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasmic vesicle membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the clathrin heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700117">
        <property type="protein sequence ID" value="OCF46970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC68238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008189.1">
        <property type="nucleotide sequence ID" value="XM_019158443.1"/>
    </dbReference>
    <dbReference type="STRING" id="1296096.A0A1B9HUM5"/>
    <dbReference type="GeneID" id="30175113"/>
    <dbReference type="KEGG" id="kpin:30175113"/>
    <dbReference type="OrthoDB" id="2113814at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071439">
        <property type="term" value="C:clathrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000001">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000002">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000005">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000082">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.730:FF:000005">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.110:FF:000003">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.110">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055358">
        <property type="entry name" value="CHCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015348">
        <property type="entry name" value="Clathrin_H-chain_linker_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016025">
        <property type="entry name" value="Clathrin_H-chain_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022365">
        <property type="entry name" value="Clathrin_H-chain_propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016341">
        <property type="entry name" value="Clathrin_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292:SF1">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00637">
        <property type="entry name" value="Clathrin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09268">
        <property type="entry name" value="Clathrin-link"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13838">
        <property type="entry name" value="Clathrin_H_link"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01394">
        <property type="entry name" value="Clathrin_propel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002290">
        <property type="entry name" value="Clathrin_H_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50989">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clathrin heavy chain linker core motif" evidence="9">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="549"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="698"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="845"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="991"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1140"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1286"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1434"/>
            <end position="1577"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1614"/>
            <end position="1641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF46970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC68238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1683" mass="189570" checksum="FD2C293AFBD70981" modified="2016-11-02" version="1">MAAPEKPIVFTEHLQLTALGIQPASISFQSLTLESDAWICVREQLDTPQVVIVNLNDSNDIVRRPITADSAIMNPRAGEKILALKAGRQLQVFNLVSKSKIGAHLMSEDVTFWTWINETTIGIVTEREVYHWKVMDGQAAPSKIFDRHATLAGNQIINYRISHDEKWLVVVGISSNPQAGQPGSNGFKIKGAMQLYSVERGVSQPIEGHAAAFATIKQDGAAQESKLFCFAVRTATGAKLHIVEIGHQAPNPPFQKKAVDVFFPTEATNDFPVALQVSPKHGILYLVTKFGFIHLYEIETGQCIYMNRISGETIFTTAQHESTSGIIGVNRKGQVLSVSVDEDTIVPYIQQVINSPELAIKLAQRAGLPGADHIIQQQYQVYIQNGQYSEAAKIAANSPRGLLRTPQTIETFKKLPNVPGTLSPILQYFGILLEKGELNKYESLELARPVIQQGKKQLLEKWLKENKLECSEELGDLCRMTDMNLALSVYLRANVPNKVVAAFAELGQFDKIVLYSKKVNYTPDYAQLLQHLVRINPDKGAEFATQIVNDESGSLVDLDRIIDIFMSQNMLQQATSILLDALKDNKPEQGPLQTRLLEMNLVAAPQVADAILGNEMFTHYDRPRIANLAEKAGLMQRALEHYEDINDIKRVVVHTNLFNTDWLVNFFGKLTVEQSFACLHEMLKTNIRQNLQLVVQIASKYSDLLGPVKLIELFEQYKSSEGLYYYLGAVVNLSEDPEVHFKYIQAATRTGQIREVERMCRESNFYNPEKVKNFLKEARLSDQLPLIIVCDRFDFVHDLVLYLYQNGLTNFIEIYVTRVNSARTPQVIGGLLDVDCEEQTIKNLLASVTGTFPIDELVDEVEKRNRLKLILPWLNTKVEQGSTDHSVYNAIAKISIDSNNNPEAFLKENNLYDPAIVGKYCEKRDPYLAYIAYAKGLCDDELINITNENQMYKHQARYLVKRREIDLWTQVLDPESIHRRALIDQVIATAIPECTDPDDVSVTVKAFMHMELHGPLLELLEKIIIEPSPFSDNKSLQSLMFLTAIKNDKGKVMGYINKLSGYDVDAIAKVATEAGLYEEAFTIYQKHDNHAEAMNVLVEHMVSIDRGFAYANKINQPAVWSRLGKAQLDGLRVKDAIDSYIKAEDPSNFAEVIEIANRAGKHEDLVRYLQMARKTAREPKIDTELAYAYAKTDRLHDMEEFLAMTNVADILQVGEKCFEDELYQASKLLFSSISNWARLATTLIYLGENQAAVDAARKAGNTQVWKQVNAACVDKKEFRLAQICGLNLIVHAEELPALLSLYERNGYFDEIISLMEGGLGLERAHMGMFTELSVLYAKYRPEKLMEHLKLFWQRVNIPKVIKSAEQAHLWPELVFLYIVYDEPDNAALAMMERLGDWDHDQFKKVIIKVANMEIAYKAVSFYLAKQPTLLPDLLAALTPRLDHGRVVKILQNEDHLPLAKPYLIATQKLNLSVVNEAYNDLLIEEEDHVTLRSSLETHDQYDAIKLAKRLESHELLEFRRIASLLYRLNGMWEESLGLAKADRLWRDALETAAASKDVSVAEELAGYFVSIGNKDAFAAILYVCFELVRSDFVEEMSWRFGLSDYSMPYKLQQQRDTSSKIAALEKEVKDLKAKTKEKEPENEPSLMGSGLGQRLMIGGPGGGPGFGGMPNGGGLMSQPTGFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HUN2</accession>
    <name>A0A1B9HUN2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">tRNA (Uracil-5-)-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_06742</name>
        <name evidence="8" type="ORF">I206_102163</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700117">
        <property type="protein sequence ID" value="OCF46968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC68240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008187.1">
        <property type="nucleotide sequence ID" value="XM_019158441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HUN2"/>
    <dbReference type="STRING" id="1296096.A0A1B9HUN2"/>
    <dbReference type="GeneID" id="30175111"/>
    <dbReference type="KEGG" id="kpin:30175111"/>
    <dbReference type="OrthoDB" id="10250660at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030697">
        <property type="term" value="F:tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000201">
        <property type="entry name" value="TRM2p tRNA methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030391">
        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025795">
        <property type="entry name" value="tRNA_(uracil-5-)_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="RNA M5U METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061:SF30">
        <property type="entry name" value="TRNA (URACIL(54)-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51622">
        <property type="entry name" value="SAM_MT_RNA_M5U_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="370"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="554"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="554"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="527"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCF46968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC68240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="609" mass="68576" checksum="A2D8AB3C463DADD8" modified="2016-11-02" version="1">MTTQPPSPGTSSPPHKRLKSSEATNTIDIISTNEFTEINEAPIKSSFLPDPTDIIPKASTSSLTKPNGEIKVKGKKNRKQKRNLPEKYSAQDVLFHDVRDFLGTNYVDELISKKEGLEWEAPEELKLYEEVTLTVGAFTVSGESLSLFPGTKPWAIITPFAHPGDKIRAKIHKHDRLCSFADLIEILEYSEEYRGGEGDRRKYPQNGCKYFGECGGCQLQPVPYPLQLLHKKRTVQLAYQRFSNLPQDILPEIQDTIGSPKQWGYRTKITPHFDAPPKWIQKQLKENGEEAAMNSLANGNGERKGWELRIGFERKGRPGVMDIEECPIATPVLNRKMTEERKRVQETIMSFQRGATLLLRDSLPNPNPIPTSDSPFSSETTSKVETEDHIAITNHKLSVYEKVGKYIFSFTAGSFFQNNNSILIPLTEYVKEAIFPVQETKKLKVKLPNYLIDTYCGSGLFGITLNEKFEKVAGVEISNDSIIAAKKNAELNGLKDKTTWLCGKAEDIFGGLDEKGFKGEKSCVIVDPPRKGCDEPFLNQLLNFKPLTIVYVSCNVHTQARDVGYLINESEIRGKEKNWKYVVESIRGFDLFPQTAHVESVAVLRLLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HV87</accession>
    <name>A0A1B9HV87_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thymidylate synthase</fullName>
            <ecNumber evidence="2">2.1.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_06962</name>
        <name evidence="10" type="ORF">I206_101947</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dUMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate = 7,8-dihydrofolate + dTMP</text>
            <dbReference type="Rhea" id="RHEA:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.45" evidence="2"/>
    <dbReference type="EMBL" id="KV700117">
        <property type="protein sequence ID" value="OCF47184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC68028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008403.1">
        <property type="nucleotide sequence ID" value="XM_019158657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HV87"/>
    <dbReference type="STRING" id="1296096.A0A1B9HV87"/>
    <dbReference type="GeneID" id="30175331"/>
    <dbReference type="KEGG" id="kpin:30175331"/>
    <dbReference type="OrthoDB" id="766at2759"/>
    <dbReference type="UniPathway" id="UPA00575"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004799">
        <property type="term" value="F:thymidylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00351">
        <property type="entry name" value="TS_Pyrimidine_HMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.572.10:FF:000013">
        <property type="entry name" value="Thymidylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.572.10">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00008">
        <property type="entry name" value="Thymidy_synth_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045097">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023451">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000398">
        <property type="entry name" value="Thymidylate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020940">
        <property type="entry name" value="Thymidylate_synthase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03284">
        <property type="entry name" value="thym_sym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548:SF2">
        <property type="entry name" value="THYMIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="THYMIDYLATE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00303">
        <property type="entry name" value="Thymidylat_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00108">
        <property type="entry name" value="THYMDSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55831">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00091">
        <property type="entry name" value="THYMIDYLATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate synthase/dCMP hydroxymethylase" evidence="8">
        <location>
            <begin position="25"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCF47184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC68028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="333" mass="38499" checksum="9EC577B041EE8F66" modified="2016-11-02" version="1">MTDPVLESNGIPIHEREDPDHEEYQYLDLISKIMLKGQSRPDRTGTGTLSLFAPPSFRFSLENGILPLLTTKRVFLKGVIIELLWFISGSTNSNLLKEKGVGIWDLNGSKDFLEKNGLGFRKQGDLGPVYGFQWRHFGEEYLNCDTDYKGKGFDQLKDVIWKIKNNPTDRRIILSAWNPKDLHLMALPPCHMFCQFYVTLPDSNIPNDKPKLSCLMYQRSCDLGLGIPFNIASYSLLTYMIAYITDTIPFEFILQMGDSHIYKDHLEPLKIQLNRQPKSFPNFKFKRTKEEIGDIDGFILDDFIIENYKPHGKIEMKMSVSLKKFIKTKKREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HVE6</accession>
    <name>A0A1B9HVE6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-splicing endonuclease subunit Sen15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_07022</name>
        <name evidence="6" type="ORF">I206_101887</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEN15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700117">
        <property type="protein sequence ID" value="OCF47244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008463.1">
        <property type="nucleotide sequence ID" value="XM_019158717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HVE6"/>
    <dbReference type="STRING" id="1296096.A0A1B9HVE6"/>
    <dbReference type="GeneID" id="30175391"/>
    <dbReference type="KEGG" id="kpin:30175391"/>
    <dbReference type="OrthoDB" id="10002170at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042777">
        <property type="entry name" value="Sen15_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018593">
        <property type="entry name" value="tRNA-endonuc_su_Sen15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28518">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28518:SF1">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09631">
        <property type="entry name" value="Sen15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA-splicing endonuclease subunit Sen15" evidence="4">
        <location>
            <begin position="141"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF47244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC67968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="179" mass="20193" checksum="847A067695230C33" modified="2016-11-02" version="1">MSISPPSFLLPYLEKYPIQAGALLTTIYDLTLSVGWIDTRIMELGGWVVLIGHKNKSDPLRAIIPIPIHTTCLKPSSLKSIFNQLKITLINDLPKPFENLSPTINDLKNQIIQKNSSQSNLIKNDDDNISEKQNQKEEEEDEIILDKETIYTSIVTPDSTVVYYKISKGIKKPSDIPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HVK9</accession>
    <name>A0A1B9HVK9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_07078</name>
        <name evidence="8" type="ORF">I206_101832</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
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    <dbReference type="RefSeq" id="XP_019008761.1">
        <property type="nucleotide sequence ID" value="XM_019158148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HW96"/>
    <dbReference type="STRING" id="1296096.A0A1B9HW96"/>
    <dbReference type="GeneID" id="30174812"/>
    <dbReference type="KEGG" id="kpin:30174812"/>
    <dbReference type="OrthoDB" id="38531at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057688">
        <property type="entry name" value="DUF7928"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408:SF3">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25550">
        <property type="entry name" value="DUF7928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="517"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="556"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="958"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="996"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1037"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1089"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1122"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7928" evidence="4">
        <location>
            <begin position="280"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="3">
        <location>
            <begin position="768"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF47542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC67675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1151" mass="129181" checksum="7C3529CED86270D9" modified="2016-11-02" version="1">MGIFGKAKPAFSPPELPVHDPVPPRATQRRVSLFPSLASIGLVEPDADAPIDPITRGRTFSGEQQRGINGRKLSQAIVPAWHRKASEALARRDTNPVNLRLGETTRFNQDGMNNAFYKSKLTIDNGSSDEEDSDGEFAPDRLSVTRKTRRNKGKGKARATSDALPGWEAAPPLKARIKKGKGKDKKSKNKHRSKRVMRRLDENLDAYNAYAQNGLVPLTRAANATRDETLALNPPPMSIGNTILEEDENMVKSASHTMSLNTAAQSDHPRAVLFGDGFDALDVMADHIFRLGVQKKKWFKAPRMGVRRNEAATGVTIRARTGLYRTFPVDYEALKPFEEAITRLNPEVAIKIKSDIVGTIFDTYINPSPSMNELVIDENTRIQILDNIELLARARKHQYAAFVRSEQVLVVWADAVENVIPAAEALEESLIQFIWQGPEVNVKFNQVMIHDAKNREEERDQERRDSENSNEKYGIDGVVLPELKADDNGSMKTKEEDLDPEDIAKREMKRKWRERPVMMIAPVSDGLAIMLLITIISLGIRTLLKEFLLDGKPIRFVLLIFAPGLMCVATFAAMVIINSVGQIFGPVRQVTQNSRYFSGIAPKRTMGELAHVTVKLPVYKESLEEVIMPTVESLKAAITTYERQGGSVGILICDDGLQLLSKAEADKRRRFYFDNNLAYVARPGHGVDGFIRKGRFKKAGNMNYAAALSLRVEEVMDDLRPAAMEKLDPDHFWNELDENDIYDAALAQALEEKEGKAWAAGNIRIGEIILIVDSDTRVPEDCFADAVSEMQESPEVAIIQHASGVMQVAHHFFENGVAHFTRMIQHAISYCCASGEVAPFVGHNAFLRWSALQECMFVDPDDGANKIWSEDHVSEDFQIAVTLQIKGYTVRWATYSGSAFEEGVSLTVDDEINRWQKYAFGCSELVFKPMKSWFRGPITPLFHGFVWSDIPIHSKFSICGYIFSYYAISIAWLTTVANYFIEGFNLPVDGYYLNSWKITLVCLTVFTGLSNVAYIVLRYRLKVPDSSRLAVDQIKWIPYLTIFFTGMSMPLSAATVAHLVGYNMTWSTTVKTVEKSNFFLQLPIIWRRFWPQLSFFGLCVPMMIITSGSLMPAGYRIGSHSIEVFVPMGIITAAHLLYPFALNPWFLSFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HWG7</accession>
    <name>A0A1B9HWG7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_06502</name>
        <name evidence="3" type="ORF">I206_101525</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008818.1">
        <property type="nucleotide sequence ID" value="XM_019158205.1"/>
    </dbReference>
    <dbReference type="STRING" id="1296096.A0A1B9HWG7"/>
    <dbReference type="GeneID" id="30174871"/>
    <dbReference type="KEGG" id="kpin:30174871"/>
    <dbReference type="OrthoDB" id="43122at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38700:SF1">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38700">
        <property type="entry name" value="YALI0E22418P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="762"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1071"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1402"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1437"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="534"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="763"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="814"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="835"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="871"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1402"/>
            <end position="1416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF47599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC67615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1458" mass="158329" checksum="2D90D6CAE823AA91" modified="2016-11-02" version="1">MADPTYSPHQIGELLFEKEPKYLPQQQHIPLSSSSSINQSYHSRFRYHAQPQSQASIQLYDSYFPPQAQSSSSSNYSSSKQTTQTQTNNVDEIIYRYSSEFDRITQAPGTPTVGIYSQDGLWDEDDLDFNPKHSGGASSSRKSTLTDKKNNRSGTIYTATPVEGKSWTWRRPSMSQLNSPSIAVETQPPMPLTAPPKGLEKKKSKGLLRGKGRRGELFVNVASDPDESFEAPPPLPIPATPSSFITESTPASYSSSTFSPVNYPSPILDTPSLISTPPLTVASASTNKPSKAASSWKRGMQKIFKSKSSIALREAAQKEASMSPPPPMPNPPLPPTTSRLEKPFSSTPPTEMDQRRIKESIPLHTAGYLSTPPSATTDAFVTPLFPNFPTDPFASSLDLTCNNPIPSPTVEALRPSLKHNSPSLRDLKSFLPNATKPAILKAKSFATLHQREDHRSTVTKINTQSRANHSSKLSKRMSSLVGLNVFAYSAPERAGSNLVTSEYLERPPTQASLAPPIESPPLLPPQPSYFTKASRSSSLPSITTDSSSSPEESPTLSIQPPNAPLPPIPGSSSTSNLTAPMQRSGSGAVLLPRSRSTSMSFKSPPTSSSFFDLYEQLGIWPSAEKDKKEIQEEPEEISDTAGIECEKLQAISNITAAEEEKENISPPVEVFTTAEEDLEHAVDITEDISKSQVQLNMPRSNTDSSIASWNVALNSFPAAPCGDVLDFGLPYVADEEGFEPMASGSQEPHDQSDALSIVAVAASSRNSSHQTTVDNSMSTDKRGSGSTVTHATSVGMSHLASSSSSKRPGRAAGSGNSSRDNSTPGSRDDVTDREEILEDSEDDDVPLSKLHPEAAAAQLQRRETRKRTRQARLDKQAKAVERRKSEKTQGRNPGGEHSWDGEGGVPPGILSKKLELVISRRAENEAAIAIARIAEGSAVSNPVQGLKAHRSMRENVPTQLDHGVRRAQSQGHAHVSLVSPTFKDTPAVPPIRTAIPLRHPQTYGLFNPESAISPTNTSFGRTPSAKHGDSNSVVAMLGHNHQEPSASYGQGRSQAYPMSQPMAVYDRSRQNSVATTVSSRLPPAPNGTRAPSRQDDLPILSAQVTRSNTNATQYSIASSAVPRVRAHSNGLSPITTHKEDSAALHVRSTTEPIPSTSASKNTTVLPIANNASAGPAQRVHATVPAFISALNGKKIMLDLTTTTTAREVLVNTYHKGDLADASVGKSWVLCEIFAEMGCERQIREYEPLLPIVKGWDSTAKFNCLVFKQSNRGMPTWARAVPTNPPMLGQWVQYETKKGKWTKRWLETRGGQVFLAKNEKNKDEVHFNSLFFDIYAITRGYDSPRPATFMLKRVEPASNFEDSQDYAHIFSCDEGIAFKLMAAIYDAKSYSIAQSYPQMINNQLPSPSSNSNANHSGSMRKHSNISSVQNVISSKPLINLENDDQNHKSGFTGKGLLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HWK1</accession>
    <name>A0A1B9HWK1_9TREE</name>
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        <recommendedName>
            <fullName evidence="5">DUF962 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_06557</name>
        <name evidence="3" type="ORF">I206_101471</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC67562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008871.1">
        <property type="nucleotide sequence ID" value="XM_019158258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HWK1"/>
    <dbReference type="GeneID" id="30174926"/>
    <dbReference type="KEGG" id="kpin:30174926"/>
    <dbReference type="OrthoDB" id="5511466at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009305">
        <property type="entry name" value="Mpo1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34205:SF2">
        <property type="entry name" value="DUF962 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34205">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06127">
        <property type="entry name" value="Mpo1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF47652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC67562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="169" mass="18778" checksum="8C8C4D51D06144FF" modified="2016-11-02" version="1">MSTSKSSLANPTYEPVSAPPGGFQSFQSFYPFYLGEHSKPLTRRLHLVGTSIALASFARSTLSLVPNLLASAAKSLPASHGIHALHNKGFLVSLGLDVYLAKWSYDTQFLEIEGAGRWLLGGVVGAYAFAWISHFFIEKNKPATFKYPIWSLRGDIKMWWEVITLRRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HWS2</accession>
    <name>A0A1B9HWS2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_06594</name>
        <name evidence="4" type="ORF">I206_101435</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008907.1">
        <property type="nucleotide sequence ID" value="XM_019158294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HWS2"/>
    <dbReference type="STRING" id="1296096.A0A1B9HWS2"/>
    <dbReference type="GeneID" id="30174963"/>
    <dbReference type="KEGG" id="kpin:30174963"/>
    <dbReference type="OrthoDB" id="5580261at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="MRX11"/>
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        <property type="entry name" value="MIOREX COMPLEX COMPONENT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28002:SF1">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 11"/>
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        <property type="entry name" value="FLILHELTA"/>
        <property type="match status" value="1"/>
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        <location>
            <begin position="112"/>
            <end position="130"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="156"/>
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        <location>
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        <location>
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        </location>
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        <location>
            <begin position="72"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF47688.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC67527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="311" mass="35354" checksum="9196D973F075801B" modified="2016-11-02" version="1">MLRQSTKYIIERQSTSVLNIRNVRGTQQDIFSNRPNVTRIFKYTTNSKEKSNINSNFSSINSKNQTNSQLHSTPTSTSTSSSSNLNSTSKPKSKLILKYIENLNKISKKTGVSINLLTISFLILHELSAILPIFLIYWIFSIFGIGLNLINYISFITSSSSSSSTQNKNSNYKEKVEVKEEEEEEEEEEEEVEEIKPVDGFIKKLIKNWYFEGESRIEKVGKKYGILGFEKIQKQKIDINHSNINKIEEGKKAIDINTNSGTTIKVANAIAAYVVVKALLPLRIAFSIGFSPTFARYTLIPLQNTFKRLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HX96</accession>
    <name>A0A1B9HX96_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Importin beta-2 subunit</fullName>
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    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_05741</name>
        <name evidence="9" type="ORF">I206_107415</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
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            <taxon>Tremellales</taxon>
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    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI894014">
        <property type="protein sequence ID" value="OCF47878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009097.1">
        <property type="nucleotide sequence ID" value="XM_019157457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HX96"/>
    <dbReference type="STRING" id="1296096.A0A1B9HX96"/>
    <dbReference type="GeneID" id="30174110"/>
    <dbReference type="KEGG" id="kpin:30174110"/>
    <dbReference type="OrthoDB" id="951172at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000402">
        <property type="entry name" value="Related to importin beta-2 subunit (Transportin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="7">
        <location>
            <begin position="31"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="334"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF47878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC73445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="929" mass="102441" checksum="5D25C7B3D7E3A537" modified="2016-11-02" version="1">MSWQPSEQGLQEVLGMLRDTSSTDSEVQRNVAQRLDQLRDVPDFLAYLAHVLIHCTGEQDSHRAVAGLLLKNSLNSRSGPVNNDNDARAMAYVKATVLNGLADPDQIVRQTAGTVITSLISNEEPGGWPEALDALTKGMGSSDANIIEGAFNSLQKICEDAPHKLDFQIQGKNLLDHLVPQFIEYTAHGAPKIRLYALQILQSLLAIRVPSVTANIDTYIQALFAKAADESPDIRKCVCASLGLILGTRPDKLVPEMSNVVDYIAFCTQDEDDTVALEACEFWLTFAEDPTLKDQLRPYLPKIAPLLLKGMIYSDWDIAILDIDDVDENVADKETDIKPRNYSSKVHSTHESNDPSSSKGGAGGFSREAQDKAFDQDEDNLDDEDEDDDDYFDDEDGSGEWNIRKCSAAALDVIAVSFGNDLLEILLPHLRDRIFSQEWTQRESGILALGAIAEGCIDGLEPHLPQLIPFLLKTLQDKKALVRSITCWTLGRYASWCVHVNQADKTQYFIPTMEGLLQMVLDGNKRVQEAGCSAFATLEEEAGTEMAPFLEPILRNLTFAFSKYQQKNLLILYDAIGTLADSVGQALGQPGYLDILMPPLIERWQRLGDQDPDLVPLLECLSSISIAAGGSFSTYTGPVYERCLRIIHATLSQYQVFEQNPEEVEEPDRTFIVVALDLLSGLVQGLGDQMHPLIRDGQPPLLHLLALCLTHFEPPVRQSAHALLGDMSMTCFPLLKPVVPQFLPSVIEQIVVEPPADCISVCNNAAWAVGEIALQYNGDSSALEPFVPSLISRLVPILLNTKSPKSLTENAAVTIGRLGLVCPALVAPDLPNFAQAWCTALWEIKDNDEKDSAFRGFCMLISANPEGIQNSFIFFCNAVCKWQHPSGQLDQMFRTILQGFKSGLGANWEAQTNTFPPVIRQRLAERYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HXI7</accession>
    <name>A0A1B9HXI7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_05848</name>
        <name evidence="9" type="ORF">I206_107520</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat ESC family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894014">
        <property type="protein sequence ID" value="OCF47982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009201.1">
        <property type="nucleotide sequence ID" value="XM_019157561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HXI7"/>
    <dbReference type="STRING" id="1296096.A0A1B9HXI7"/>
    <dbReference type="GeneID" id="30174217"/>
    <dbReference type="KEGG" id="kpin:30174217"/>
    <dbReference type="OrthoDB" id="7318948at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051243">
        <property type="entry name" value="PcG_WD-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10253">
        <property type="entry name" value="POLYCOMB PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="176"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="248"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="444"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="497"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF47982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC73548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="600" mass="66857" checksum="0F32F003BAD5D1FD" modified="2016-11-02" version="1">MDPPEIIDLTEDYPTPSSQALPSSEASEHEAEGSIAGSSLKWYKKVNKRMGRGGHPYACQAIAVQGASGDTLRYEDVKFWPYVGPLNPWKTPRSVEEAWNNYDNTVAICAQKKMIVGRCTDRDPWKVLWEMDVDDDLYTLAWTYHLFTCHPLIAVAGKKGFVHIIDAVLKRCLRVLRGHGGDILRLAVHPTHPHIIASTSYDKTTRIWNILGSDLPIIPAGERYNENFPMGDADEGDCTFAILAGEGRGGHRAYVADAAFHPTKNAVATVGLDRQVKIWPLPQLPKPSINPLPTPIGYKAKIVHLPLFSTSKLHADFVDNVEWLNEYTLMTRSRKEVKIWEWTAFSRFFRPDSLTSRTSEPSSADYTDSGSFSLVSEYPIGSDCWAMNASFHRQFTPTSQEVINFEKNEHLVTDPLIALTAHRESNGPLPEILLFNPLLAEDGVSPTPITRKRLRDRRDSSSSNENDSEHESSEFMSSPEKTKDGQRSVGRPRKIQSGRSMESSSFQNGTSTPGRSITKSEGTTSVSPEKQSGTQSNKSLEPWRLVATDYQALMRQNRQKGLKIFAAGTNLCNVAISPRGAEWIIGVGEPGTVFVWKIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HXJ9</accession>
    <name>A0A1B9HXJ9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_05847</name>
        <name evidence="4" type="ORF">I206_107519</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894014">
        <property type="protein sequence ID" value="OCF47981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009200.1">
        <property type="nucleotide sequence ID" value="XM_019157560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HXJ9"/>
    <dbReference type="GeneID" id="30174216"/>
    <dbReference type="KEGG" id="kpin:30174216"/>
    <dbReference type="OrthoDB" id="2564908at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628207" evidence="2">
        <location>
            <begin position="28"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF47981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC73547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="203" mass="22201" checksum="37D51814B2444E7E" modified="2016-11-02" version="1">MDFLSSSVDIAFFLLTLLIIYNQPILPTSSSTTEQQNEIHPPNQESNLPDSPLPSPGYLSVPSITITPSSLGNLPIKPPLPGAGGVKGKHKKKSVSFSLSSMDDLKQNENTLSNSNVIKRFRPPTPFFKSSSSNHQSILLNLEMSPINNENSLSSPINNNAVIQKREKELGVNEELEKGQLDHGILQEDSMGIQKKWLVTGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HXW6</accession>
    <name>A0A1B9HXW6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">tRNA (uracil-O(2)-)-methyltransferase</fullName>
            <ecNumber evidence="3 11">2.1.1.211</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I206_05958</name>
        <name evidence="14" type="ORF">I206_107625</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>uridine(44) in tRNA(Ser) + S-adenosyl-L-methionine = 2'-O-methyluridine(44) in tRNA(Ser) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10339"/>
            <dbReference type="Rhea" id="RHEA-COMP:10340"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74478"/>
            <dbReference type="EC" id="2.1.1.211"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TRM44 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.211" evidence="3 11"/>
    <dbReference type="EMBL" id="KI894014">
        <property type="protein sequence ID" value="OCF48091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009310.1">
        <property type="nucleotide sequence ID" value="XM_019157670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HXW6"/>
    <dbReference type="STRING" id="1296096.A0A1B9HXW6"/>
    <dbReference type="GeneID" id="30174327"/>
    <dbReference type="KEGG" id="kpin:30174327"/>
    <dbReference type="OrthoDB" id="10047021at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141101">
        <property type="term" value="F:tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011671">
        <property type="entry name" value="tRNA_uracil_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210:SF0">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07757">
        <property type="entry name" value="AdoMet_MTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 11" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCF48091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WWC73653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="679" mass="78492" checksum="57BD565951B8B168" modified="2016-11-02" version="1">MSNSIAGGGFKPPPFESNKIPEGIKSILTSEEEEEEEEWIPIISSKCYFPIKIFFSTIKSLSLHPERNSSLILRADILPFNSTDKNKDKTFILRDSNDKLELFEELNVKLLPKQPRRDSKIDQNILFYRSNTESIEEDEIKGKTKEHGLVITIPQIKFENEIPFYHPKVKKLAYHYESIIPEEKFNKSETNKLKEEESELQKEEEVKGIISIHYLPFKNSEISKLNENLETLSIEEEEQNLIPDPELIPRSKKIRKRSPLAGPSIEIDSKKNNEIINPPAIILNQNADIPINVKKDKNGRIASEGFERLFRTSLSLLETIHRHGYGQLVGYQKRRIHDVIVPRDNFQDLYLILKDRHRQLDSRAPKQGGLSKLEDVKRHVWKRQSLLSTPDDNSLPTKVDLSEWGEQDIAIAAFLMLLWKDMYPPLPLSEVVSKNEEIQEEIREWDTWGRPEGGFIDLGCGNGLLVHILISEGYNGKGYELRSRRTWPLYPLKTQEALIELPIDPPSWFPDTIEEWQSGIWPNKPKDLIGENSFLIGNHADELTPWIPLLSLLPSIPVPYLSLPCCLHSLDSHFDILDFIAPEHPHSPKGGFENGLEPGISRYQSYLIWLGWFGLKCGWYWEKEGLRVPSTKGWGIVARKRWTTNEENKECREWALEQVNEVKRKGAFKVREKEGKDHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HYM1</accession>
    <name>A0A1B9HYM1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pirin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_05160</name>
        <name evidence="5" type="ORF">I206_107296</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC73329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009602.1">
        <property type="nucleotide sequence ID" value="XM_019156884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HYM1"/>
    <dbReference type="STRING" id="1296096.A0A1B9HYM1"/>
    <dbReference type="GeneID" id="30173529"/>
    <dbReference type="KEGG" id="kpin:30173529"/>
    <dbReference type="OrthoDB" id="10261807at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd02910">
        <property type="entry name" value="cupin_Yhhw_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43212">
        <property type="entry name" value="QUERCETIN 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43212:SF3">
        <property type="entry name" value="QUERCETIN 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin N-terminal" evidence="3">
        <location>
            <begin position="8"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF48383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC73329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="274" mass="30929" checksum="A6BDD5AF77759C6A" modified="2016-11-02" version="1">MQFKFRANEDRGGADHGWLKTFHTFSFANYYDPFYEKFGCLRVINEDRVLPLNGFPKHSHKEFEIFSYIISGELTHKDSLGNIEKLKKGNIQMTSGGTGISHSEFNENLKEQVHFLQIWSLPFKNELKPKYFTRNFENFEKENKLLHIVAPIGYEGVEEIRECKGLTPIHSPLHFFASLLSPNKSVIHKLLSSINGKLTKKIYIHLVQTSGYNTKSASKDGKGPLIQISGGSELTKLGEGDGVFITSGKVGEEIKIENIGNGVGEVVLFEMDDE</sequence>
</entry>
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    <name>A0A1B9HYQ6_9TREE</name>
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    <gene>
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        <name evidence="2" type="ORF">I206_107289</name>
    </gene>
    <organism evidence="1">
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
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    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC73322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009609.1">
        <property type="nucleotide sequence ID" value="XM_019156891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HYQ6"/>
    <dbReference type="GeneID" id="30173536"/>
    <dbReference type="KEGG" id="kpin:30173536"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCF48390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC73322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="169" mass="19259" checksum="951E34CC3B5C2EF5" modified="2016-11-02" version="1">MNRSNSDMSVGKSGSNLVPHLNKNLSGMRIGKTKNSKWSVLSYNLTHPAKIRCPNPWPAFLKSSYAYKAGISSQLPHTQDAYRYVVLWLDGLAWDVIYRLGMIFDSGNYNDIQNRPSNETRKWSMMHTYFINPNITMMRVLNYTMLSGPPVTIVSMTVSNPDEVSWTCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1B9HZK4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">F-box and WD-40 domain-containing protein MET30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_05441</name>
        <name evidence="8" type="ORF">I206_107016</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
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            <authorList>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HZP9</accession>
    <name>A0A1B9HZP9_9TREE</name>
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        </recommendedName>
    </protein>
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        <name evidence="9" type="ORF">I206_05548</name>
        <name evidence="10" type="ORF">I206_106907</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Nonessential protein required for the fusion of transport vesicles derived from the endocytic pathway with the Golgi complex.</text>
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            <topology evidence="8">Multi-pass membrane protein</topology>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the SFT2 family.</text>
    </comment>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
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        <property type="entry name" value="Vesicle_transpt_SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137:SF36">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SFT2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="156"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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        </source>
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        </source>
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    </evidence>
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        <source>
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</entry>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Nusbaum C."/>
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            <strain evidence="2">CBS 10737</strain>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
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                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        </source>
    </reference>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
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    </reference>
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                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
        </source>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="OCF48835.1"/>
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        <source>
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        <source>
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    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
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<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
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    <gene>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
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    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC71952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010266.1">
        <property type="nucleotide sequence ID" value="XM_019156464.1"/>
    </dbReference>
    <dbReference type="STRING" id="1296096.A0A1B9I0J0"/>
    <dbReference type="GeneID" id="30173103"/>
    <dbReference type="KEGG" id="kpin:30173103"/>
    <dbReference type="OrthoDB" id="10255344at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="15"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="191"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="760"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1010"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1549"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1697"/>
            <end position="1819"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="235"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="951"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1086"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1191"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="771"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1697"/>
            <end position="1714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1719"/>
            <end position="1736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1769"/>
            <end position="1798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF49047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC71952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1819" mass="205021" checksum="00CEC670F0D86D1F" modified="2016-11-02" version="1">MSFIGAGELEHKVTQLQRQLDHKDHELNSIKNEQRKKDEDLTKAKRAKEDAEYKLRDEAERAHQAEKTMTTKTNEITQLKLKLSNLESSLDQANEKLKKEEKDNERISNALDEALNSGSDGASQQIKSLQSRIKQLEANLKSIEQEKEKLQSQGQGNSNDPWGSGEPLTRNERNRLMVLQNQNENLREENARLQASGASRTSSSTNDIFGAASSPSRPKTKRRSMSASGPAPSELIELENQVMTLQEQLALRKKDLDKAVNEKLALEITSKKKMQKMESDMEDVKEELDFYRRNQDSGSNLEINKLKKAMQVENDNLRAQLTEKTNEIAVKSQEIQGLEKRVELISALESDLEKERKARISLEQLPTSAGLPTESLAAEEKIRTLEAELLKVRSNSTHTSKGDVEIRQVKRELQKTLRDKEYLESLVKENDELLAEKDEEIQRMRTAIPVPGSPVLHPTGERTEELENEKMALEDQIQQQKDKYEEELKVIDSRLQDTMNRLAELTVVEQQLRAECKQAQNKVNIANIERDDINSQLQELNAEMCARKDEYEILSLQAQQLRADLGQAREMNLASRQQIDQLREQLDTTQKSLVEKEKIIDDLESQRNELAITASTRQHDDAEYAELEEKFKAAERDLIGAQADLVTMEKQKAQMEKKVEISNIQSEAAAQQMKDLTANLAAVEAQMEESEVRAKASSKEKDDTVRVLTDQLDDLKAELSALQIELDDRNTELAASRASHDEVEGRFEEAVKSLNEVQGRLGDMENAQADRSTESEAREKDEELFHLKELKDRLAQELNNAREQHEKELTATTSKQEQDLLETQTRIQELEKHVERLQSALSAAHDAKKAGAISDNEALHRMEQKISQLRSERDDLRHNLSFVQNERHFAIRAATSDKESAIEDVKRMKEALKQSNLVREKLQAELDVVNESRSAGREANDAENAEMSDRITSLESALADQADKVKSLELALQNKAGTLSSLRSQLLSSESRAEGLQKELLEMIHHVGQTAKLSEPPRPPSSFSENNDLPTDLVPTLNNGSGERTRRTSLGHMRSRSNVSVSANTLQNLNMERQLQARIGRRDARIAELTHDLEKANLNLTLAKEAQEETLEEISELVEAKDRLQRQLRQNQTVQEEDPEVLRNLVLSLVIYRQSHQSSQMRHGVAVDALSKTRIAAGKLRASITEHEYKASESAQRIHDMEQERSTLERQIKAIQEEEARSRTGLKEAQEAIEALQTRINTHEAASASANEEAQILSAIEAQVAEKEERIIALNAQNTEYTARVGVLEKELIELSRSKDEKIAELGTKVDELESVLRDVTQKVQSLEAEKAGLIEEISAAERALEEGTQESALEKDRFESTNHELTIRIQELKEQLNAKVNELTEGLEKSESLETKLRVAEARETELVASAEADKVVMDGLRQELQNLKQSAEGESQAVIILKEELITLKGSTKIAEQDKQALAREITELKDVISSKDNVQESSRKRLDETIIELQAAKEARIVVEDMISEIKGELERSEGAKRSAENSLKEAQIKLDELSAQIESTRQELAGSREQSEMAKTASDEQQVELERLVSENTELKVQLVTAQSQIAPKTDVDEGMINDLKERIEQLESSLTQKTEEVDEADDRTREAFKANAKLEKKLGKLQRQLETAQVEKNTALNKLATQPIIAPPPQPISQVNSAPTTKQRVVSAPSPANIQTQRTPLSSVNIFKPTPNSNPNSNLEENTNANAKIGHKRHREDEPIKSIGTEAILQTPDMTKPIIKTQSVSPNKTNKSSFTPQRGLHTQSQQQNLDIGKQRPAFPLPPTRSVFQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I0S6</accession>
    <name>A0A1B9I0S6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_04827</name>
        <name evidence="7" type="ORF">I206_106004</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010358.1">
        <property type="nucleotide sequence ID" value="XM_019156556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I0S6"/>
    <dbReference type="STRING" id="1296096.A0A1B9I0S6"/>
    <dbReference type="GeneID" id="30173196"/>
    <dbReference type="KEGG" id="kpin:30173196"/>
    <dbReference type="OrthoDB" id="10255969at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43117">
        <property type="entry name" value="OSMOPROTECTANT IMPORT ATP-BINDING PROTEIN OSMV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43117:SF4">
        <property type="entry name" value="OSMOPROTECTANT IMPORT ATP-BINDING PROTEIN OSMV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="19"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="298"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCF49139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC72044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="547" mass="61911" checksum="A5C193F3FD11B3FB" modified="2016-11-02" version="1">MSKSLPLVRFPPNALIHRLGSPNTSISTALLRFPEQGWTINKDNKEGWAIVGDSEGRKLAIDTLLSRHRIHPLTPPPGPFPYLSNLPSSIKGELSTYKPIRHLAFSRPTPTGEFTDFTARYGALLEEDKLTFLENLLKTLNYSIEEKEIKKVMKLMGIENLLNLPNISLSSGQIRKSRIALSLLTKPLLLILEDPMSGLDFKSRKEVSKILGNLNNNSNNNNNNNNNEPRIILVIRDKNLNNLPDWITNVVEIKSGKVWIGSKNEFLSSYSTLENGNENTKIEEVNFRKGEEEGKEVVKLDKVSVSYGEGSRPVLNEISWTIREGEKWHLVGANGSGKTTLLSLILGHHPRSYSIPSESLTLFNKARREISTVELKSMIGHTSPEIFIAFPRNMGLSAYQTIGSGFKGIFTRSQLNENQKERILNLLNQVKDLLQPTTNLKVNKEEEEGMKLKEIALKEFSHFTHSQQNLLLFLRSIIGKPNLLILDEPSQGVDEIIWERCKLILKNEWKNNPKMSTIVVSHYQDEVPWREGQGRVLKLDKGRATME</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I0X3</accession>
    <name>A0A1B9I0X3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_04865</name>
        <name evidence="11" type="ORF">I206_106042</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010396.1">
        <property type="nucleotide sequence ID" value="XM_019156594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I0X3"/>
    <dbReference type="STRING" id="1296096.A0A1B9I0X3"/>
    <dbReference type="GeneID" id="30173234"/>
    <dbReference type="KEGG" id="kpin:30173234"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043359">
        <property type="entry name" value="GLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="184"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF49177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC72082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="387" mass="43245" checksum="FC59D3D90C335043" modified="2016-11-02" version="1">MTSINSSPPSSSPLQAQSSPILSNYDSPKPNQEIDESKPKSKVKSKKKRKSKLPEVELDDQIGDLLGEEELEVEVEEENQNEAGPSISNKGGKKVKTEEIDELADETKVEGDGNQGTFKCEWGDCEEVNGTHNGLIEHVKEDHINALKDAFICEWINCPRTGQKQASRHSLSTHMRMHTGERPYACTYAGCPKSFTRSDALQKHIRSQHIERPPKPVPPPPAISLNQTTPGISKATKNKSKARHAPIASTPLTRTPLNALPISDEDLLLDEDIAEVLPRIRKREILNPTFEEIEALNYLRSIFPRQILDSKNPIPDSLDEPPSELGIPEEAQLIQSVPDPDIPGGELDLLGRSEWQARYIMIKARLMLVEEENSMRRMELLQLLQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I0Z5</accession>
    <name>A0A1B9I0Z5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">aspartate kinase</fullName>
            <ecNumber evidence="2">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_04873</name>
        <name evidence="10" type="ORF">I206_106050</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aspartokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="2"/>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010404.1">
        <property type="nucleotide sequence ID" value="XM_019156602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I0Z5"/>
    <dbReference type="STRING" id="1296096.A0A1B9I0Z5"/>
    <dbReference type="GeneID" id="30173242"/>
    <dbReference type="KEGG" id="kpin:30173242"/>
    <dbReference type="OrthoDB" id="4323675at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1B9I175_9TREE</name>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Murphy C."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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        </location>
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    </evidence>
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            <dbReference type="EMBL" id="OCF49293.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC72197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="174" mass="20309" checksum="84AC60984FB81DFD" modified="2016-11-02" version="1">MSSTYHEAMDEGTIPTSNSGDNTYKKDQDVDYSYLHPPERDGTVPGAERRNKWWIDTSDEGKKWAKSVLGLLRDKDQNGVQTIDSKTATKIIEASIRTNYFKKHGYTERFCDNPHLHEYQTVLNHAVLEFCTSLKEEKPELHDMWCRERAPEEVTLPDAKKSLDWYFSNPDRYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I1D3</accession>
    <name>A0A1B9I1D3_9TREE</name>
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    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_05025</name>
        <name evidence="9" type="ORF">I206_106200</name>
    </gene>
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        <name type="scientific">Kwoniella pini CBS 10737</name>
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    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
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    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the cullin family.</text>
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        <property type="protein sequence ID" value="OCF49334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="kpin:30173394"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031461">
        <property type="term" value="C:cullin-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000001">
        <property type="entry name" value="Cullin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000002">
        <property type="entry name" value="cullin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000034">
        <property type="entry name" value="Related to Cullin-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000036">
        <property type="entry name" value="SCF ubiquitin ligase subunit CulC, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cullin family profile" evidence="7">
        <location>
            <begin position="446"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="357"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="377"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF49334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC72238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="807" mass="91916" checksum="E0BE9EE2C8659D8A" modified="2016-11-02" version="1">MAMSMGAARRGKPKIRPPKRPTSETPIKDTWTKLANAIREIQNHNASKLSYEEHYRYGYNMVLHKHGDQLYNGVKALIAEYLDRLAEEKIVPTFPRSGGTRGAGKLGGGAEAIERALEGDRFLKAVKSAWEDHTGSMRKIRDILKYMDKGYSFANGLPLIYDVGLTLFLSHIIRSSKHPIHTHLISTLLSQVQLERDGETITRSTIRECTDILLRLNVPEREGGKTVYVTDFEPEFLKRSAEFYGLEAIEELEKGDAAQYLRRVERRLAEEADRTVHYLSTTTHPALQELLIANLLTPHLQTILDMPGSGLVVMLDSDRIADLRRLYSLYLKVPRDAGKTSLRAALRLDIEERGKNVNEGSSIEAGPSTIDQDDDQAEGKGKGKEKEKVKSAPTNNALSSALKWVQDVLDLKDKFDNILDSAFMGDKQVQVSINEAFQSFINANPRAPEYLSLFIDENLKKGTKAKSDSEIESALEKTIVLFRFLLDKDKFERYYKNHLARRLLYARSASDDSEKQMVTKLKMEMGFQFTQKLEGMFTDMRLSNESANTFRNYLNRHGALPIDLSVNVLTASYWPQPIVATNTCTFPTALQPAMETFQRYYDSRHSGRRLTWQGNLGTADVKVRFKNRSHDLNLSTHALVVLLLFEDVKSGENLSYPEIKSLTDLPDSDLIRTLQSLACAKFRVLTKIPKGRDINPNDKFEFNENFTSPLARIKIMQIASKVENSKEREETQEMVDEERKHQVEACIVRIMKDRKIMSHNDLISEVAHQLSTRFSPSMSLIKKRIEGLIDREYLERTDDMGSYRYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I1F7</accession>
    <name>A0A1B9I1F7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_04970</name>
        <name evidence="7" type="ORF">I206_106145</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010500.1">
        <property type="nucleotide sequence ID" value="XM_019156698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I1F7"/>
    <dbReference type="STRING" id="1296096.A0A1B9I1F7"/>
    <dbReference type="GeneID" id="30173339"/>
    <dbReference type="KEGG" id="kpin:30173339"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000135">
        <property type="entry name" value="Peptidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF74">
        <property type="entry name" value="AGR407CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628290" description="Peptidase A1 domain-containing protein" evidence="4">
        <location>
            <begin position="20"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="718"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="5">
        <location>
            <begin position="107"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="400"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="400"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCF49281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC72185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="740" mass="77531" checksum="9DFB97A13FF66EC2" modified="2016-11-02" version="1">MITTQHILTVLTLLSISLASLPPAHHPAQNLETSPSSIPEIRSKGYLPKIQNRRKSTQLYKRGPSVGISDVNLEIHERAASVDIGKGKRALNVNGTEVNLGTAQNTYVVPVSIGSPASIYPLQLDLASSDLLVASTLCTTTTCPTSLGPTVNAYYDVSKGSSGFEVVNGNKTYWNSSYADGTTASGIVVREVLTMGEVVLDGQVMGLMNATNLTLSQQKISGIIGLGFPRLSALSHILLEPTTADDTSSSSSSASISASSAANSASSSISTSSASSVSTTSSSKATPTYYPPVLENLVSQPHVPYPVFALALAPPPSNTTSTSTATSSSATSSSTSRYQSQIGSLTLGGVSNHYISNDTDSGRTVDDIEWHQVIPFGKAKSSTNDSAQALSRTNTISSTAISTSASTTPTSSSSANGDSSRKKRSSSSELNTFPSNLDELGDEEYLFWTLELHNLSLNGTDITLNSSYADLGLGSLALLDVGFNGISGPQQDVVKIFEKISDARQVDEGQWVVPCNTKMTLGFSFGGRYIQLQPSDWISTQIDSSSLCLAWPIVAPSTGDGMDWQLGTPFLKKVYSIFSYGINGIQAPLVGFLPLENNPTSTNSGNGTNTTTYNPDSPTPTTIEELHLTTTIQTILPNQILPDPTYTTPSYVYSTILQTGINQYIGLANNSIYSEIEEVPVVSLDSAATSRMASMAGGENGGSAASGSGTSGASKNDLSLIGIGMISGLFLGVFGILGHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I1H9</accession>
    <name>A0A1B9I1H9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_05080</name>
        <name evidence="4" type="ORF">I206_106254</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010606.1">
        <property type="nucleotide sequence ID" value="XM_019156804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I1H9"/>
    <dbReference type="STRING" id="1296096.A0A1B9I1H9"/>
    <dbReference type="GeneID" id="30173449"/>
    <dbReference type="KEGG" id="kpin:30173449"/>
    <dbReference type="OrthoDB" id="2597023at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="84"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="404"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF49387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC72292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="519" mass="59527" checksum="41C850D4AC170AF0" modified="2016-11-02" version="1">MSYQRCDSYRPRNQPKRDRDERTYSPPSSEYSHRKKSPSPFTEYNRSSPTSRRYRSDKLSPSSRKYRTNKSRSPPTIPQTSPIKHSNIFKGLTFYIDRSNYDSKTLLHLRDLIRFNGGSLYARPYESYVTHIITFIPSSKMKNQIWYIENRNNLNSEKPGMWDWTQMDLIRHFSKLVGPGSNDYWSKYNRKHVIREEWLNQCIKYNKLFDISGDYDGWEIKAMVNQPEVVPQDSLNKSKITQTDNTAIEENHDDPAKVSGNETNDALDKLATLSPQTSELLIEDHHAETSYVDLEIEVEVKREKEDEDSSIVNRLTYNTGFSRSKSQDEIPKTPVTHLFQSDLAEAKAPQRSSNKNNLQADDLSIIQVLNQNPSQYRLDKDGTTSTTSPIHTRSFNTSSVSNPTRSKVFERGIIPLTFFVHGSGSNKVFTEIAISDRGGFIVSPSYASIFTFPSSGYSIQDDPKGLEILKHLSNQPGRIAISVDWVQHCIEQDDLLPLDEYIISYKENSLMTPPASCQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I1N8</accession>
    <name>A0A1B9I1N8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_03987</name>
        <name evidence="12" type="ORF">I206_104432</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010685.1">
        <property type="nucleotide sequence ID" value="XM_019155727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I1N8"/>
    <dbReference type="STRING" id="1296096.A0A1B9I1N8"/>
    <dbReference type="GeneID" id="30172356"/>
    <dbReference type="KEGG" id="kpin:30172356"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000061">
        <property type="entry name" value="MFS sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF28">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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                <person name="Litvintseva A."/>
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                <person name="Young S.K."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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                <person name="David-Palma M."/>
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                <person name="Mohammad A.W."/>
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                <person name="Yurkov A.M."/>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Litvintseva A."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Heitman J."/>
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                <person name="Sun S."/>
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                <person name="Mohammad A.W."/>
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                <person name="Yurkov A.M."/>
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    </reference>
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    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="569"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="238"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="266"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="314"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="404"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="418"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="583"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="604"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF49959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC69993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="668" mass="72777" checksum="E0E32ABD1C852972" modified="2016-11-02" version="1">MSQYPNNFNAQAFFGQSQSAPALNGNANANGTASPNPNMNTPSPMMGSIRPSALQNFNNSPVASPTPNRPLQFNSSQLASLTDFHQRQQALLAVQQAQAQARAQGQNVNVPVGQGQPRPNLQAMQQILHQRLQAQQQQNALQNFLQNANQNQTQNQVITPAQLQAQAQAQIQAQTQTPPLPLGHLVPSTISPQAKPNPTPPKPLTQNPAFNPALLNAAKIAQNTLNISNPSFSLNLSQTLPSGSSAQQSNNIPTKPANIPLTQTFVPPPDAIRPPSPVKTDTKAADKMDKADGGEKKDEKEKEKKKRPKKKKEKKEDEKDKEKADDKEKGKDKDDDKDSNAPTPSAEKPVKPKKPRTEEEKARRAEARRKKIAADREKAAAAAAAAKTNGEGDEGVFSAAPTANDATPSGEGTNGTKVGEEKDAKEPELKPIEPKAVLATPAVAPETRSRRQEGMRGSMRNEIARLMYGAGDVPEPDIDTVDYMEDMVTEFLADLCRPIPPLRPTLTSQPLPVPLSFDVIRHRLKTPAYGKYLERFDHMVYMSEILKQHRRIANPNLNDLVETVGNDYLGLDDPSANPNGLKRSGEGDEEGRTKKRGRPNSQKVLKDKSEKRKPGPQKGWKLNRDPNAPSLKRLIPGMGAIGQKRKYIRKITTPGAGGGVKREGSINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I4H9</accession>
    <name>A0A1B9I4H9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">mitochondrial processing peptidase</fullName>
            <ecNumber evidence="5">3.4.24.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Beta-MPP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">I206_03739</name>
        <name evidence="19" type="ORF">I206_105351</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins. Preferentially, cleaves after an arginine at position P2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.</text>
            <dbReference type="EC" id="3.4.24.64"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.64" evidence="5"/>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011636.1">
        <property type="nucleotide sequence ID" value="XM_019155482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I4H9"/>
    <dbReference type="STRING" id="1296096.A0A1B9I4H9"/>
    <dbReference type="GeneID" id="30172108"/>
    <dbReference type="KEGG" id="kpin:30172108"/>
    <dbReference type="OrthoDB" id="10251424at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000002">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000001">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF149">
        <property type="entry name" value="GH01077P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="16">
        <location>
            <begin position="54"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="17">
        <location>
            <begin position="206"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OCF50417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="WWC71396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="479" mass="52911" checksum="743B05168B936936" modified="2016-11-02" version="1">MVASRLISRALARPPTPRVLKPALSRNLAAVHPVTLPSLDPETKTSVLSNGLSVSTETIPGAQTSTVGLWIDAGSRADAEGASGTAHFLEHLAFKGTKSRSQTQLELEVENLGAHLNAYTSREQTVYYAKSFDKDVPQTVNILSDILQNSKLEESAIERERDVILREQEEVEKQLEEVVFDHLHSVAYQGYPLGNTILGPKEHINSISKSDLQNYISKNYTADRIALVGAGSIEHDALVKLAEKNFASLPVSSNPIPLGGQAHPPTDFLGSEVRVRDDTMDTLNLAIAVEGVSWKSPDYWPMLVMQSVFGNWDRSLGASPLLSSKLSHIISSNNLANSYMSFSTSYSDSGLWGIYMVTENLMNVDDLVHFTLKEWTRMSISPSIAEVERAKQQLKASLLLGLDGTTAIAEDIGRQLITTGKRYTPKEIERYVDSVTPEEIQRVARKYLWDKDIAIAALGRTEGLFDYNRIRADMSSMIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I4V2</accession>
    <name>A0A1B9I4V2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_03873</name>
        <name evidence="3" type="ORF">I206_105218</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
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                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
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                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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                <person name="Heitman J."/>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Goldberg J."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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                <person name="Mohammad A.W."/>
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                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
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                <person name="Young S.K."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
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                <person name="David-Palma M."/>
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                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
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                <person name="Yurkov A.M."/>
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                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COX17 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF51170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012389.1">
        <property type="nucleotide sequence ID" value="XM_019154986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I6L6"/>
    <dbReference type="STRING" id="1296096.A0A1B9I6L6"/>
    <dbReference type="GeneID" id="30171605"/>
    <dbReference type="KEGG" id="kpin:30171605"/>
    <dbReference type="OrthoDB" id="2558495at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1130:FF:000005">
        <property type="entry name" value="Cytochrome c oxidase assembly protein subunit 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007745">
        <property type="entry name" value="Cyt_c_oxidase_Cu-chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16719">
        <property type="entry name" value="CYTOCHROME C OXIDASE COPPER CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16719:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE COPPER CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05051">
        <property type="entry name" value="COX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 8" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR607745-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF51170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC68950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="81" mass="8630" checksum="8E67B450A9DF9092" modified="2016-11-02" version="1">MSLIGSSSSTPDSSRSSTPETSSKAVNPLNPQGLKPCCACPETKSKRDDCFIKSPAGEGDVNCREFIEAHKACMRGYGFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I6M0</accession>
    <name>A0A1B9I6M0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Peroxin-10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">I206_03251</name>
        <name evidence="23" type="ORF">I206_102901</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="23" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF51185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012404.1">
        <property type="nucleotide sequence ID" value="XM_019155001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I6M0"/>
    <dbReference type="STRING" id="1296096.A0A1B9I6M0"/>
    <dbReference type="GeneID" id="30171620"/>
    <dbReference type="KEGG" id="kpin:30171620"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000671">
        <property type="entry name" value="Unplaced genomic scaffold supercont2.18, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025654">
        <property type="entry name" value="PEX2/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350:SF0">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14634">
        <property type="entry name" value="zf-RING_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="21">
        <location>
            <begin position="302"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="OCF51185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="WWC68965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="359" mass="40424" checksum="1D22C8CC656F57B5" modified="2016-11-02" version="1">MDQPIASSSRLPPPSLPDVDEETNKTTFELAAQRQILKSYQRDSSQINKLIDLVSETIRNIAGTRWLARKQLIIDLLVKGVYLSLTFGRGIQTIGEEYTDILPFHSRRGKLPSKKRRIITILLILLPSLIFSPVTSNYLRHEDLENSNNQSRLQKAKLTLARFIESPIGKLIPEIHMMLFSFRGKFFEMARRITGVTYVSTQSPKAFESQPATYEPLGLMIAIPLLHRLIRSLSSNIEHTENLTNIGILTPYKDDLLPLSPPLTPPLTAEETILIKADQKKLYDKLNTYLDEETLNLPERQCTLCLESRGTSSGSGGTTAVTECGHVFCWGCLGGLEKLECPLCRQALRMERLVAAYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I710</accession>
    <name>A0A1B9I710_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Neutral amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_02044</name>
        <name evidence="10" type="ORF">I206_104513</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012549.1">
        <property type="nucleotide sequence ID" value="XM_019153809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I710"/>
    <dbReference type="STRING" id="1296096.A0A1B9I710"/>
    <dbReference type="GeneID" id="30170413"/>
    <dbReference type="KEGG" id="kpin:30170413"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF479">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="54"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCF51330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC70562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="476" mass="51003" checksum="5859A1A0CC1D769E" modified="2016-11-02" version="1">MSDVEKNLNDHSASGSLDTQTIPVPEGGKYDIDDADHDAVFGVRKEGAVNYRSMGWIQATIVMLKTIIALGVLAMPTVLSATGGVPGALIILVIGLITTWTGHVVGLFKKNHPEVYSMDGVGYILGGKWGREFFTIAYPMFMIFLSGSGFVAISIAFNAVTAYGTCTVAWVVVAMVGTFALASIQTLSKVSILGWVGFVSVMAAILIITIAVGIQDRPSAAPQTGPWDKDISAVNHQGTFLGGMGAVSTVVFSYSGTPAFFNVVGEMRKPRDYDRSLYCCQSIVTATYLTIGIVVYYFCGQYLANPALGSAGVIIKKVAYAVALPGLFVSVTIYTHVGAKMIFVRFLRGSEHLTAHTFTHWAVWLGTVAGCVTLSFILAEAIPFFGDLVNLIGATLGTLMCMIACGWMWLHDNLPRRKTDKSLYYKMLVVLNVAIIIAGFFIVITGTWSAVVAIRKSYSTGLITSPFSCADNSNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I7E1</accession>
    <name>A0A1B9I7E1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase subunit a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_02085</name>
        <name evidence="13" type="ORF">I206_104551</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012590.1">
        <property type="nucleotide sequence ID" value="XM_019153850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I7E1"/>
    <dbReference type="STRING" id="1296096.A0A1B9I7E1"/>
    <dbReference type="GeneID" id="30170454"/>
    <dbReference type="KEGG" id="kpin:30170454"/>
    <dbReference type="OrthoDB" id="10264220at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026028">
        <property type="entry name" value="V-type_ATPase_116kDa_su_euka"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF63">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001293">
        <property type="entry name" value="ATP6V0A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="418"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="471"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="547"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="580"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="642"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="779"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="679"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCF51371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC70600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="847" mass="95959" checksum="E9E761C5AD75A841" modified="2016-11-02" version="1">MSTNYPSLFRSEEMSLVQLYIPSEVAHDTISELAEMGDFQFKDLNPSLTSFQRPFTPRLRRLAEMARRLRLFRSQITGLSPTLGIPPLAAVPPFTTVGPRAQNAYDELEEKLKEHERRLTDMNKSWEELGKRKSELEEKRWVLRETAGFFNEAEHRHTEIRTSFDESDNAPLLEHAAEYGNLPGEGGLSGFDLEFVSGTIERSRMPTFERILWRVLRGNLYMNYSEIEEPFVDPTSGKETHKDVFIIFAHGEELLAKIRKVAESMGGTLYNIDSSQDKRSDALREVSARLEDVDTVLYNMGQTRRVELSKIAEQLEAWTDAVRREEEIFKTLNLLSYDQSRKTLVAEGWCPSRDITAIQLGLRRAMDTAGTSVPAILSELRTHQTPPTFHRTNKFTEGFQTLIDSYGIATYQEINPGLYAVITFPFLFAVMFGDIGHGILMFLTAAAMIFWEKQIAKGGVNENLETFFFGRYLIVLMGAFSIYTGFMYNDIFSKSLHIFNSAWEWPHNATGLVEAIPTGHRYAMGMDPGWHGADNALIFNNSYKMKLSIILGVIHMTFAICLQVPNHLHFKKYLNIYAEFIPQMLFFHSIFGYLVICIIYKWSIDWSTASTAPPGLLNMLIYMFLSPGTIEPGTQLFAGQGFIQVVLLLIALVCVPWMLALKPYMLWKEHQRIKGQGYHGLTGQENGHNGGERHSTEHLDEEEEEVGMAVAESSDEDHPFDMGDIIVHQVIHTIEFCLGCISNTASYLRLWALSLAHAQLSEVLWSMTLDLALEYEGGVIGGGLFVFFMFAVWFGGTVAILCVMEGLSAFLHALRLHWVEANGKHYMAGGYPFTPLTFANLGAEEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I7G1</accession>
    <name>A0A1B9I7G1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_02214</name>
        <name evidence="9" type="ORF">I206_104676</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012719.1">
        <property type="nucleotide sequence ID" value="XM_019153979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I7G1"/>
    <dbReference type="STRING" id="1296096.A0A1B9I7G1"/>
    <dbReference type="GeneID" id="30170583"/>
    <dbReference type="KEGG" id="kpin:30170583"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016652">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19120">
        <property type="entry name" value="AKR_AKR3C2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044494">
        <property type="entry name" value="AKR3C2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="27"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF51500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC70725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="297" mass="32903" checksum="3825189A8D713F57" modified="2016-11-02" version="1">MPWEDIKLNDGRKIPGISFGTSRHSGDTVSTVDEAIHAGFNSLDTAQIYKSENAVGQAIKESGIPRKELWITTKWSGLKNAKESIKDSLNHLGVNHVDLYLIHFPAVAKDDIPGSWAHLEEFKKLGYTKSIGVSNFEISHLKELLHHAKIKPSVNQIPFHPNILAKQEPLIKYLQENEIAIEGYSPLAPLWQDGAGAPVLKAVKSLASKYNVPEERILLAWTRSKGVIPVTSSSTKSRIESFIAAGDLTLSDEDIKSIDKAGYKAFLLTELKKSLINGVKWFTVAGLVTYFAVRRYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I7G7</accession>
    <name>A0A1B9I7G7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleotide exchange factor Fes1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_02216</name>
        <name evidence="7" type="ORF">I206_104678</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FES1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012721.1">
        <property type="nucleotide sequence ID" value="XM_019153981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I7G7"/>
    <dbReference type="STRING" id="1296096.A0A1B9I7G7"/>
    <dbReference type="GeneID" id="30170585"/>
    <dbReference type="KEGG" id="kpin:30170585"/>
    <dbReference type="OrthoDB" id="10250458at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050693">
        <property type="entry name" value="Hsp70_NEF-Inhibitors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013918">
        <property type="entry name" value="Nucleotide_exch_fac_Fes1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316:SF18">
        <property type="entry name" value="HSP70-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316">
        <property type="entry name" value="PROTEIN FOLDING REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08609">
        <property type="entry name" value="Fes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nucleotide exchange factor Fes1" evidence="5">
        <location>
            <begin position="98"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="329"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCF51502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC70727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="409" mass="45421" checksum="5B94D77403510245" modified="2016-11-02" version="1">MPDLNELLRWSIANSTQPQSQGEQASSQSQSGEQVSSSEGGLTIRYNPPSSTSNRQNGGTAVLHSSDSAPADLSPASTPGPGTPTGENPLTFSLPTTSTNESSVTKRSDLTTEMLDLILGKSDSITMKEKMAFAIDESNPLEERVEALDDFEMLIELIDNANNMPILKLWQPLLDLLSSSETEIVSNALWIIGTAVQNNIKAQAALFINNAFPLILKTYNESTSSSVKAKSIYALSASLKHWPLASKALSKKYIEINDKTGYEILLKGLKDNEKNVKKKVSFLISTLIMQSNQEYNQNELDNEVKNVIEELNKSYSNDNNNDNQKIIKGLRLSNIIKELLNNLENLNLEDNLEFEENLIKSLINALKIDELTLDEKLKFKNIWNGLNDKQKEDRGISLEEDKEVITLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I7H1</accession>
    <name>A0A1B9I7H1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-rRNA-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_02172</name>
        <name evidence="9" type="ORF">I206_104636</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the RIX1 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the IPI1/TEX10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012677.1">
        <property type="nucleotide sequence ID" value="XM_019153937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I7H1"/>
    <dbReference type="STRING" id="1296096.A0A1B9I7H1"/>
    <dbReference type="GeneID" id="30170541"/>
    <dbReference type="KEGG" id="kpin:30170541"/>
    <dbReference type="OrthoDB" id="361362at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024679">
        <property type="entry name" value="Ipi1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056:SF2">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12333">
        <property type="entry name" value="Ipi1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Pre-rRNA-processing protein Ipi1 N-terminal" evidence="7">
        <location>
            <begin position="144"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF51458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC70685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="722" mass="78894" checksum="6C5A8060CAF23151" modified="2016-11-02" version="1">MPKATKKKKEKQADFRKAKLKLGKGKKQASNATDTSFKARSIALPGQQSISRAILNADGLGPTEPTTANGLTLDDLFIRFRHPNAGVRKESIGGVKDILSIDAGRDVGKVLRALGSLVSDDDAAVRKALLGLLAWYLPQMPVASLAPHLPLLVLQTSSSLSHIFPEIRLDACKLVHLLLNHVPSHVVGNWPRESSNILEGLRLAVGLGGEKGVNSQIGRLTGGAKLVTLKAMMEFVKRGLNLRTGENDQAWSDGWIEKKVKGKGVEKVVKAEPTYEDLAENGWLIGSSFDLREDIGNAWEVGRLGGQGKEDEDGIGSVLSQLYISLHPLLLSTFLENAPTAFSPSSTSSGSAEDIPLALCTTTASLTELLARAVLTRSTQSSSEIKEVRSCISDFLKRMAAWFPFSSTRLNVVTPSGLTAGFELSLVYSNLAVLLAPRPVELIWPKDLRKEPGWRERIKAVEAAWSQMRARQNVKGKGKAKEKGADNWAMEEVASWVIEVLGPKKDILSPSLTPAAYSAILPIIFSLIVQPPSLSDEEEDIPSSVGEAFLSHLLSTSSTSSSRSTGDMFMISLIEIHEQRFPVYPFFIPTSSSVIRTKTQQWFESIPKVIWELGNRDQESTRVLLDFLLHLGLKGKTAVDETYSILKGDSFSSVSSKLSPFFHLQHPSKGSLPGSWTRLSDDRVKRLALNVASVWSEWDDGQLKESATLAVRGSSLEAYWNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I7I6</accession>
    <name>A0A1B9I7I6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_02197</name>
        <name evidence="3" type="ORF">I206_104659</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012702.1">
        <property type="nucleotide sequence ID" value="XM_019153962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I7I6"/>
    <dbReference type="STRING" id="1296096.A0A1B9I7I6"/>
    <dbReference type="GeneID" id="30170566"/>
    <dbReference type="KEGG" id="kpin:30170566"/>
    <dbReference type="OrthoDB" id="2565307at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="892"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF51483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC70708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1093" mass="121904" checksum="4FE733994199F7C5" modified="2016-11-02" version="1">MNPPPDKTPQPGTSSSPHTRPSKILGPVPSTSNGVSNAKAISASDKPAIYLPRIVRPLNRQPTPSNSTIRLNGLSTKRSHPLPLANAGKARKVTENGHIIPRVPPKFSNQEAVLEVMATEECTKTPQIRSESRSLSNNASRRAVLPREYRQIPGKGSHLSSAVKNSTSSITRNGMTVQNASATPSFSLTSGLAQPTMRSANAAIPAQRSTPLVQANSAFQHPSLTATTSQPPNPSHESSSISKTDPPVPTLSQGSIRSDSIASHGFSRTELSIPLVNPRKRRPATVSSAEGASKRAKTTRTKDAAKSISRMETTVIDMTMIDSDDEMTIQNVDLVERVKTEPTSPGKSPAQSVDPKTHLPTDDSPHGSKPGHLSLKLRDNGRDVSLEMQVRDKYPTEPLSPDEIWQVACNETDAFWDTSPSSILHRQEYVGGEEWKRRLVNLRKTRKGGAESTTRHRSACDARLPFLVRNIRSGVKGIARTRFPYLKATHTNYRPTKSSFQQFWETWTFRESNIHTCRQDLFLMVKFGHFLQIDSGPTIQTSPDSAKIEIFCNNVESSIFSMNMSLDRNMAIRPSEFKIPVHYLTELNRHHQLGIPSDVELPGTRLRITAKFLSDGKPCLDPFESPWTVFTSRNGNVMPRPRGWFRLSNKAEQRLEMRPPPAWAFDPAQILPPLPQKLSQIPTNRIVLVCRDLTYTNKVNYGLTSKHLSGFSNEEEIATYLAVIHKGNFHVEVTRELLAGTPCVRIRLRDRKMINADTQISTPSMAAPTYFPVISTLVESVTPTQEVQINKQTNSLYVSTHNSPTFEIRVDNVSDEAPANQELYDQSKAGAAIMANDVDLLMTDLSPMNVNDSMGDSLCINDKDEQPPPVTSPTRRINPNWTLLRNGLTMVPPTSVDKRKNESISLGKPTSLPSSAVGTPVLVPTSNGLVGPIMSNRINKYTNWSTRIDPGTLADLFPELDKIWDGGTSRYLIRDHEESVTWTRYHLTEKQRFMACCWNRWVYQKGPIPTSHRSDYYISFIRAYGEVMIKAGLTREIGDTLHVYWRDNHISLKEMGDTLKVWNEISGFHMKLRKAREDAENPNRLDVSVKIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I7J4</accession>
    <name>A0A1B9I7J4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_02202</name>
        <name evidence="3" type="ORF">I206_104664</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012707.1">
        <property type="nucleotide sequence ID" value="XM_019153967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I7J4"/>
    <dbReference type="GeneID" id="30170571"/>
    <dbReference type="KEGG" id="kpin:30170571"/>
    <dbReference type="OrthoDB" id="2564847at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF51488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC70713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="460" mass="52070" checksum="5446511A982851F1" modified="2016-11-02" version="1">MSLYSRQSSAFSLIDMSSTHTTPAYTDKTLTPRLIILPDDVIVQIRSILILNAQKATAGKLMRCSKAFYGLFLPVLNYPTLGLRAGTKSHGVFEGLMKVDLSDHRLDENSTIPTHTFFSKYPFPTPSTHARKLSLLQQCTQLTIHDLSSAKIIVDYQSAIGKDESQTIFPNVRKLNLGSDLIFALISGIYNQEWFQNIQDLAQSISPREICLTLPSPTMQDNMSKIPKVLLTPQDSHDIYPHFDNVVPDFGCGSSNRSNVRTIDETTLNAIMSDIWINEQQMRSLNSLLKSFKPSVATFHNVTIQSLPLISSVKKYSVYFADLGCSFRCKDKEVNFWSEVLLERVSLKRANRIMECIDRTAIEEGAEYNFIDAELHDCEVCEAARNLEMDRDSDEDNEEGNYWAFDEEKNEQSEGKVEKIVRGLISMANQDKEIADKLNKAISFCRRADLETCKCCDSKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I806</accession>
    <name>A0A1B9I806_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">W2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_02341</name>
        <name evidence="5" type="ORF">I206_104802</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BZW family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012845.1">
        <property type="nucleotide sequence ID" value="XM_019154105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I806"/>
    <dbReference type="STRING" id="1296096.A0A1B9I806"/>
    <dbReference type="GeneID" id="30170710"/>
    <dbReference type="KEGG" id="kpin:30170710"/>
    <dbReference type="OrthoDB" id="1727522at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11560">
        <property type="entry name" value="W2_eIF5C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051245">
        <property type="entry name" value="eIF5-mimic_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057397">
        <property type="entry name" value="HEAT_5MP1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043510">
        <property type="entry name" value="W2_5MP1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14208">
        <property type="entry name" value="BASIC LEUCINE ZIPPER AND W2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14208:SF2">
        <property type="entry name" value="PROTEIN KRASAVIETZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25504">
        <property type="entry name" value="HEAT_5MP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="3">
        <location>
            <begin position="267"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF51626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC70850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="433" mass="49198" checksum="78DBCC836FD4D39A" modified="2016-11-02" version="1">MSHTPTSTAPAGNADKKPSLTGVRIKQRKGQAKATAKFEPETFRDALLLHLALIPTPYTTDSLVTKLVQAGTTLEFLKYSEQLFEILFIGGLLQPGGSYLDDKRSPIYILKENSEEDPTWEQDVGVKGMIEVLKRVIQRYKYLQKPLEENFLPDLLGYLPKWNNLESRNKLSEAIALLVIDLQISPKCLISLTKEHVNKDNSALNFFTHFAKVILSKQTIDQFSSTIKRSGLKDILSVFPLQIRDKKHLDDHFKKEGLQPIVDWYARLALGEVKEETINSVERMISDEDSNEQIIETLKTQQAEKPVPESDLVDWVWQGLMRTIDMSARADQIDAFVVQYVAKYAPVLEPFTNTAKAQVNLINSVQVACHTDTRIIKSFVQILKTLYNADVISDQAIIYWHQKGAKPNGKQHFLKATEPLVKFLEEQDSDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I8E0</accession>
    <name>A0A1B9I8E0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_02485</name>
        <name evidence="3" type="ORF">I206_104946</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012988.1">
        <property type="nucleotide sequence ID" value="XM_019154248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I8E0"/>
    <dbReference type="GeneID" id="30170854"/>
    <dbReference type="KEGG" id="kpin:30170854"/>
    <dbReference type="OrthoDB" id="3146826at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF51769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC70993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="84" mass="9180" checksum="D91D21BC4981FD20" modified="2016-11-02" version="1">MSDDFETTQTNIPETAQNVELEDRRQEESEATGKISQEEVKGLKDSIGGGEVLDDSEGYTRSSNKDVSALKQEDEVDAAVADLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I8V7</accession>
    <name>A0A1B9I8V7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_02667</name>
        <name evidence="2" type="ORF">I206_105125</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
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                <person name="Shea T."/>
                <person name="Sykes S."/>
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                <person name="Nusbaum C."/>
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            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Heitman J."/>
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                <person name="Young S.K."/>
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                <person name="Gargeya S."/>
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            <strain evidence="14">CBS 10737</strain>
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    <reference evidence="15" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="15">CBS 10737</strain>
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    <reference evidence="14" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="14">CBS 10737</strain>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
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        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
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            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
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                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
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                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013321.1">
        <property type="nucleotide sequence ID" value="XM_019153160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I922"/>
    <dbReference type="GeneID" id="30169756"/>
    <dbReference type="KEGG" id="kpin:30169756"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="161"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="235"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF52102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC69667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="272" mass="31669" checksum="0B93BAA39F0CCB23" modified="2016-11-02" version="1">MPLPQLPSSCPPKRPRYVPSSSWPNPPPSPLVPTKKVKLEIPTSPRNRAIIHPAPASSNYSLPPHRILPPSSPYPTDDTTTSPKHTLASPTSTYTENPNSTQQSSTDKNAHEMIKENLEKYKNFNLNDDINYKKLSNIAKIAQIEKEKYYKNQYENRTKILEKSIKDIIHLKEENDSLINELSNIKMNNKFKENENFELNYKLKEIIKENEKLKKLLNDSEIFNKEENLKYDQSIREYLIKMNKISDEKSKLEKDKLILEEEIHNLKMKLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I9M2</accession>
    <name>A0A1B9I9M2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable vacuolar protein sorting-associated protein 16 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_01355</name>
        <name evidence="6" type="ORF">I206_103642</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Essential for vacuolar protein sorting. Required for vacuole biogenesis, stability and to maintain vacuole morphology.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the VPS16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013290.1">
        <property type="nucleotide sequence ID" value="XM_019153129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I9M2"/>
    <dbReference type="STRING" id="1296096.A0A1B9I9M2"/>
    <dbReference type="GeneID" id="30169724"/>
    <dbReference type="KEGG" id="kpin:30169724"/>
    <dbReference type="OrthoDB" id="1792at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098588">
        <property type="term" value="C:bounding membrane of organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.780:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 16 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.780">
        <property type="entry name" value="Vps16, C-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016534">
        <property type="entry name" value="VPS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006925">
        <property type="entry name" value="Vps16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038132">
        <property type="entry name" value="Vps16_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006926">
        <property type="entry name" value="Vps16_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04840">
        <property type="entry name" value="Vps16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04841">
        <property type="entry name" value="Vps16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007949">
        <property type="entry name" value="VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps16 N-terminal" evidence="4">
        <location>
            <begin position="6"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Vps16 C-terminal" evidence="3">
        <location>
            <begin position="535"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR007949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF52071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC69699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="862" mass="97407" checksum="E9535C9D06E154FA" modified="2016-11-02" version="1">MALSSPTATWDTIQNVFYRKEEIYSMSWSIQDLSDYKISVGKNGGPIAIIRNENKILSTKKHSIGKPKIEIYNSSGILKSNILWDLNEKPILIHFTINNLIIILKSGLYRIYDLSNLSFYKQFSSLGGLLNNTNNNNEEEDGIINILEVKAYEEGMVILTSNLEFLEIRGWNGSRAIPLISSGLIEKPSSWAILSPDISTTAHIQIIISTFSTILTLDTLEKIDQKIIKGPFSNISISPNGKFLALLNKKQLWVVSIDFNRNLSEVDLNQFFSDSSEIIEEIQCEWCGDNAITLSWNGKVILIGPGGDSLSWDYSPAVQIVGEIDGLRIISSGTCEFVQKVPDATLAVFSPGSSHPAAILYDALDHFERKSPKADESIRSIRPDLGNAVDTCIEAAGRELEVIWQRKLLKAAQFGRAFLDLYNPNDFVTMAQTLKVLNAVRYYENGIPITYEQYIASSPSTLILHLLSRNLHLLALRISQYLNLRPDPVLSHWASAKIIRSSQKGVDPSDGGLGDDEQICKAIVDKFEKEGERGVSYAEIARKAWENGRARLATMLLDHEPRAAEQVPLLLQMKEEKIALEKAVDSGDTDLVYQVLLHLRSTLSPGDFFHILDDSISPKLKPAVNLLQVYARQADRDLLRDFYYQDDRRTESGCLEMEEASQQAYAEDRLEHLKKAAKAFGESKERQFESKMADDSYRLLTLQQIYEKELDQKFTFSGLSVNAFIHKLILEGFTKRAERVRIDWKVPDKRFWWIKLKALAERKDWEGLESFAKSKKSPIGYEPFVTHLLSLTPPQPTHAASFVARCDPRQRAELYVQCGDWGKAAESAKERNDRGKLDELKRRAPNGIAQREVDEVIRRVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I9R5</accession>
    <name>A0A1B9I9R5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_01472</name>
        <name evidence="8" type="ORF">I206_103524</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
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    </reference>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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    </reference>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
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    </reference>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
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    <reference evidence="6" key="2">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
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                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
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                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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            <end position="238"/>
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            <end position="48"/>
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    <evidence type="ECO:0000313" key="7">
        <source>
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        </source>
    </evidence>
    <sequence length="327" mass="37176" checksum="B504EB05A8BAA742" modified="2016-11-02" version="1">MTTTNLKRPSSPVEDNQVESSTKKIRSSSPSSQLPCDSSTINSNSEVATDSNSKKISIHEWLHPNDEQINQTIITHSPLLHESSSTFITFTLSFLPFSNQIKQISTLEKECKRIIRELNVINLINELIFSQDNQNQGAFEKKNLIILTKNGKEKIREPDHRIWACRTLILRQGKDGTKGEDDYQLHEASFDDNEKYGGQTILRALRENKGIDVLSVCCRWYGGDMIGPIRFQHITTTVITSLKSTLKLMNLRDLRINIESLDEEIIHLRSKLSSISENFTSSQSQSTIQNGKGKYDEIDDEKKLERLVIAREKTKDALEKKLANQGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IA64</accession>
    <name>A0A1B9IA64_9TREE</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
    <gene>
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        <name evidence="3" type="ORF">I206_103194</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">CBS 10737</strain>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC69256.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IAC1</accession>
    <name>A0A1B9IAC1_9TREE</name>
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        <lineage>
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    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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            <end position="518"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
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            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF52423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC69343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="518" mass="56170" checksum="9ADB59A9086B94BD" modified="2016-11-02" version="1">MTQSANMDSTLVPTPIENLDPANANFEQQAQHVTIRKRDFGFLPIPRSRRHDPHKTVTEEFGFTWKMNLVFAFASTVSVMNLYYIQPMLVAIADDFSVSHTRISSIPTLVQGGYGVGIILISPLGDLVRRRQLVLILITLTTILSIGLALAPTVAALEAISFIVGILTVTPQICIPWTADLAPANKRATSMSITLSGLIFGLVLGRVLGGIISNFASWRDTYWLAVGLQGCMTLILYFTLPDTPDKNIGLSYFGVLWSMVKYFTMYPTLVQACLVSMFSSAVFAGFWTSLTFVLNNSPYHYNSFEIGLFGLLGIIGALLAPQWGRLVDRVHPYLGQITGISINLVSMIVALVGANKNISAVCISIIGYDMGQQLTQVSSSYRIAGLDPKARARLNGCSLLAVFVGQTSGTAILTHIYNSHGWTPTGGTAVAFIGAALIVLFIRGPHEIGWIGWSGGGQILKKEKLTDLSPEAITEKIKIKITKQEKVNPQEQSASNSEVTPEQNDSIPATTEKGAAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IAC8</accession>
    <name>A0A1B9IAC8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_01693</name>
        <name evidence="8" type="ORF">I206_103301</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="OCF52404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC69362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013623.1">
        <property type="nucleotide sequence ID" value="XM_019153462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IAC8"/>
    <dbReference type="STRING" id="1296096.A0A1B9IAC8"/>
    <dbReference type="GeneID" id="30170062"/>
    <dbReference type="KEGG" id="kpin:30170062"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF32">
        <property type="entry name" value="ARGININE METABOLISM REGULATION PROTEIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="417"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="445"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
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            <end position="66"/>
        </location>
    </feature>
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        <location>
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            <end position="87"/>
        </location>
    </feature>
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        <location>
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            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
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            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="486"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF52404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC69362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="547" mass="61818" checksum="ACEC32E7EB027AE1" modified="2016-11-02" version="1">MSLASEESPEIQRPSLLPRPQGAHHDQQEDLRSVLANVPHSFGTTRSYVDMPSSDRSNNNPTQSHEILSPRPRLPASLSTLLNQSESVRLEDRERTSSDLSSFRRSSASPRRPAHQASDVQERGPRVRTPCRPILTPQRHSYHSNISRPTHPSRDAFRTFPPNRSRPSTPPRPIEQQVRRRPEQNLPHLSETTIGQALSPLRPGFARNVSDDRRSEVNFQSGNVRYSTEMQRSVTLPNRPGGYTPRPDQPRHTEILLILNQDRRRDMRNWSAGDSQRYEQGYRDAIRDVASGHGRVGNKNINIRIHDPRPEEQLLSTEPLTRSTPVIGMPPPRSLQVQQQQRRNDNLRIDSHLAQLPMTHNWSNHSPSALPTPALLTSQSIVHPPPASDYFGTAFHHTGQSNPSYSPPKRGKRQQISCYPCRSRKLKCDGKKPCAQCSRRHIDGHCDYAPNIKRRGRGKKISNGGRGRGGSEEHDTEESTTMARKRYSDHDEGHGESSAMAQERSRRYNQDDQYDIGELAMDGGMGTGSRPSRPGSEKGEERNEEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IAN4</accession>
    <name>A0A1B9IAN4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_01985</name>
        <name evidence="3" type="ORF">I206_103009</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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                <person name="Litvintseva A."/>
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                <person name="Litvintseva A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
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                <person name="Sun S."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
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                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
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                <person name="Cuomo C.A."/>
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                <person name="Litvintseva A."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="kpin:30170323"/>
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    <dbReference type="Proteomes" id="UP000094020">
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="MFS_Sugar_Transporters"/>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00083">
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    </dbReference>
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        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="176"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="517"/>
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        <location>
            <begin position="77"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IBL1</accession>
    <name>A0A1B9IBL1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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        <name evidence="3" type="ORF">I206_100997</name>
    </gene>
    <organism evidence="2">
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        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC67090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="30168698"/>
    <dbReference type="KEGG" id="kpin:30168698"/>
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    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF53028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC67090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="155" mass="17614" checksum="838B76FFA1C41D9A" modified="2016-11-02" version="1">MSSSSSSERKKAEEKLKAKKKEEEEIKRKRKEYLKKCDPSTIEELINSKEIESKWFEEGKWRPGWANVEFDEDACLKNVLKNKADGFYTPAGTILPLGAQMPEMTVLKYGGYFPEGTSFPGGVSVPMHARMVNLLPEETQSKYDPKIDESLCSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IBR9</accession>
    <name>A0A1B9IBR9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_00396</name>
        <name evidence="3" type="ORF">I206_100930</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Abouelleil A."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
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                <person name="Goldberg J."/>
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                <person name="Imamovic A."/>
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            <strain evidence="1">CBS 10737</strain>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 10737</strain>
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    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
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                <person name="Birren B."/>
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    <reference evidence="2" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
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            <strain evidence="2">CBS 10737</strain>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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            <strain evidence="10">CBS 10737</strain>
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    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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            <strain evidence="11">CBS 10737</strain>
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    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000036">
        <property type="entry name" value="Glutamine-dependent NAD(+) synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000003">
        <property type="entry name" value="Glutamine-dependent NAD(+) synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02090">
        <property type="entry name" value="NadE_glutamine_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014445">
        <property type="entry name" value="Gln-dep_NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090:SF9">
        <property type="entry name" value="GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="NH 3 /GLUTAMINE-DEPENDENT NAD + SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006630">
        <property type="entry name" value="NADS_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="9">
        <location>
            <begin position="3"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00052340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF53034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC67084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="712" mass="79494" checksum="9A393110A36D587F" modified="2016-11-02" version="1">MHLVTVATQLDQWSLDFEGNCKRILKSIAIAKSRGATLRVGPELEIPGYGCLDHFLEGDTILHSWEVLATILQSEEAQDIVCDIGMPIEHKNNNYNCRVIIHSGKIVMIRPKMWMANDGNYRELRHFTPWHKHRQTEQHSLPRIIRNVTGQDYVPFGDAVVSTEDTVIGVELCEELFTPASPHILMGLDGVEIFTNSSASHHELRKLNRRIDLIKEATMKLGGIYLYANQQGCDGDRLYYDGASLIAMNGQILARGSQFSLSDVEVITATVDLGAVRAHRTTSSRRMQSAQSEAYQRVYVDTRLDGGQGIRVGDDETKGTTEVKYHTPEEEIALGPACWLWDYLRRSRQAGYFIPLSGGIDSCATTVIIHSMCRLVADAASKGDEQVIADARRIAGEPEDSSYLPTDPKEFAGRIFYTCYMGTEHSSPETRKRAKDLSEAVGGYHVDLNMDTAVSAVKGIFSLVTGKRPQFGVHGGSSAENLALQNIQARLRMVLAYMFAQLLPWARGKTGGLLVLGSANVDESLRGYYTKYDCSSADVNPIGGISKTDLKKFIAWAEVNFDLPILKSFLDAIPTAELIPIGADNVAQSDEVEMGMTYDELSVYGRLRKVEKCGPYSMFGKLVQEWGTFLSPTEIAQKVKHFFFNYAINRHKMTTLTPSVHMESYSPDDNRFDLRPFLLPSRFNHQFRKIDELAEKLPNRATQPGNDKAKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9ICD7</accession>
    <name>A0A1B9ICD7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear speckle splicing regulatory protein 1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_00487</name>
        <name evidence="6" type="ORF">I206_100839</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NSRP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014405.1">
        <property type="nucleotide sequence ID" value="XM_019152267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9ICD7"/>
    <dbReference type="STRING" id="1296096.A0A1B9ICD7"/>
    <dbReference type="GeneID" id="30168856"/>
    <dbReference type="KEGG" id="kpin:30168856"/>
    <dbReference type="OrthoDB" id="446635at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053246">
        <property type="entry name" value="NS_splicing_regulatory_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018612">
        <property type="entry name" value="NSRP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47845">
        <property type="entry name" value="NUCLEAR SPECKLE SPLICING REGULATORY PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47845:SF1">
        <property type="entry name" value="NUCLEAR SPECKLE SPLICING REGULATORY PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09745">
        <property type="entry name" value="NSRP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear speckle splicing regulatory protein 1 N-terminal" evidence="4">
        <location>
            <begin position="104"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="197"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="325"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="360"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF53186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC66932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="441" mass="50030" checksum="FC647A6C3800110D" modified="2016-11-02" version="1">MSSNGTKLSFSFAAPAAASSSKPGPSSTPKSNMELLMAKSKPSSSSNLPSVGKKPTLPFDEDGDDDDDDENEGGLNALAGPSKKQQNKNKAPIGQTNLLSRSERKAQKVAESIDQSIFDYDKHYDTMKSIEKAHEEIRKKEAEERKPKYIESFLASAQTRKLDKLRAEEKMLSREREKEGDLYQDKEKFVTDAYKKQMEQVKKAEEEEKKREDELRKSRSGPGLTSFYKSMLESSEAENAAAVAATQAQSVPSFTVRPPTSGPSRDDFDDEEEYDPLLAREAKSVNEKAGSSRVDEKSGKDVEINDEGEIIDKRSLLKAGLNIMKKPKPTLPNSLLTSQRSGEINEGPYKSRAVGTAASHTERMERERKRLAEQMKEQVEKKRREEEERIRKEEEEARKRREGDNGDAEKRRQDAKERFLARKRQREEDEKKEKEKKAREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9ICZ7</accession>
    <name>A0A1B9ICZ7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_00575</name>
        <name evidence="4" type="ORF">I206_100752</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A1B9ICZ7"/>
    <dbReference type="GeneID" id="30168944"/>
    <dbReference type="KEGG" id="kpin:30168944"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="31"/>
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        <location>
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        <location>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
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    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="244" mass="25525" checksum="33120F2B11C4BEDD" modified="2016-11-02" version="1">MIAFGTMFSSTYFSLFSILALSATSLISATASSSDENTATSAVVSSCSRRVPASGPTSSTDSGPSETATIAGTSIPPVSSAWAGVVASLAAEAGSSASESSGSTASAAATQGTNSTGSEDSEKNSFRYLVKLDPYTCGMCYGRFMCNDQSSDGQTVSIILPTLHPNDHSWFANWTFTAYDHTEGEDIQSWAAGVPVKTFGCKFEILAGGSKDENTTVEFHHKSPYVKGIDDKNLLEMTCEDMKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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        <name evidence="2" type="ORF">I206_100576</name>
    </gene>
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        <lineage>
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    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCF53446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC66672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="598" mass="67888" checksum="6164CFD62019B9DB" modified="2016-11-02" version="1">MCLSKRVVSDADSKSTIAKTKNKTFQIDADSTPTGYFLAFFGADIPLLPPTSLVDTVKLVNLCEMFESTAEHNKLLQQRLQEQSKDKVWELLSIASQLDDRALGRQCLDRMDMNSFVYGREPGDSKGGDFQGKMSRLSYEWQGRLYSLALKQEKMTAQRPQPHYRISRKDNRIFDGYKDEPTEVTAMEFIDDWSMLLSRWKRQYLPQHRKGKQKLKSGPDRRKIGIWLLGIITAYLTWQIGSKYRQQAEKHSRYVETAFTTRRQVQVFMPIDKPRAYKNPDFCKTLWSAVVSGYRVTLYNWDIRTKTTSIEEEFDTHKPKVSGLARILSNNQLLQDLGILPQDFVFLVDAMDVILQLAPSVLISRYSLLPGGLEGKPIIAAVFNCWPNAWNSSACLDIPASPLPSDMFYPTGQKLSPTMAVLPIHANSGLVLGSVSELRGLLQKVDATIASPEYPWAQFDQGAFNIHLQKRELVVDNTLSMFYCAEHHTNSLSLLPVGGSLKPSDKYQYPFTISHSDLPDTRPVGKDRRTLNIPVAMHFNGIGAKPGFNQYWDDMFSDVNAADAQTRNWQETKVRIVKKSGREEMSVKEICGTQLGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IDB1</accession>
    <name>A0A1B9IDB1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Threonine dehydratase</fullName>
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        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Threonine deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I206_00760</name>
        <name evidence="16" type="ORF">I206_100565</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
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            <text>L-threonine = 2-oxobutanoate + NH4(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
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        </reaction>
    </comment>
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            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from L-threonine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1296096.A0A1B9IDB1"/>
    <dbReference type="GeneID" id="30169129"/>
    <dbReference type="KEGG" id="kpin:30169129"/>
    <dbReference type="OrthoDB" id="4418812at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04907">
        <property type="entry name" value="ACT_ThrD-I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01562">
        <property type="entry name" value="Thr-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1020.10:FF:000001">
        <property type="entry name" value="L-threonine dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000008">
        <property type="entry name" value="L-threonine dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1020.10">
        <property type="entry name" value="Biosynthetic Threonine Deaminase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001721">
        <property type="entry name" value="TD_ACT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038110">
        <property type="entry name" value="TD_ACT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005787">
        <property type="entry name" value="Thr_deHydtase_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01124">
        <property type="entry name" value="ilvA_2Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006674">
        <property type="entry name" value="PRK09224.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF11">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00585">
        <property type="entry name" value="Thr_dehydrat_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51672">
        <property type="entry name" value="ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7 12" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ACT-like" evidence="14">
        <location>
            <begin position="515"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCF53457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="WWC66661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="598" mass="65478" checksum="F01403617C8E1F62" modified="2016-11-02" version="1">MVATNGLAIPSRANGISSSSSHSFSKSPPSYMEYTSSAPFPPATKHDDNEEIPSHLYEKLPNHILETNSKGQKTPDYLKMILMSKVYSSPLNLKETPLTHAVNLSAKLGNEIWLKREDLQPVFSFKIRGAYNMMASLSEEEKKKGVVTCSAGNHAQGVALSGHSLGIPAIVVMPVSTPSIKWRNVQRLGAKVVLHGRDFDEAKAECSRLEKSEGLTFIPPFDDPYVVAGQGTIAMEICRQVRDANEISGIFASVGGGGLTAGISAYIKRVAAPSVKVHGVETVDGDAMDRSLKKGSRVTLDEVGPFADGTAVRIVGEEPFRVCKEYLDGVVLVNNDEICAAIKDVFEETRSIPEPSGALALAGLKAHILRNNLVGANKKFVAVISGGNMNFGRLRFVAERAEIGERREVLISIKVPEKPGSFLKFHSLLEGRAVTEFTYRYSSPQTGYIICSFILSCASSSATGPTPEARQKEINELFENFKKEGIEAFDLSEDEFAKSHVRHLVGGRSDVEDERLFRFEFPERPGALGNFLKGMKSDWNISMFHYRNHGSDVGKVLIGIQVPKDSYDAFGDFLSELGYVYVEETQNPAYISLLRTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IDQ2</accession>
    <name>A0A1B9IDQ2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="7">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_01066</name>
        <name evidence="11" type="ORF">I206_100259</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="7"/>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014978.1">
        <property type="nucleotide sequence ID" value="XM_019152840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IDQ2"/>
    <dbReference type="STRING" id="1296096.A0A1B9IDQ2"/>
    <dbReference type="GeneID" id="30169435"/>
    <dbReference type="KEGG" id="kpin:30169435"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08558">
        <property type="entry name" value="PI-PLCc_eukaryota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000039">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF36">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="9">
        <location>
            <begin position="528"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="31"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="476"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF53759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC66358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="823" mass="92269" checksum="393FBFE67ACFD10C" modified="2016-11-02" version="1">MSPPESPKINYFSMLRLTQNNNLGLKSKANSIHSAPVSPTGEETDSYFPSVPGPTPARTRPKRRFTLPTRGTSLPPTFEMDSTAVDGIVPLALVQGVPMLKISSRKMKQVIMRIRNDGISWSSKKDNTVSINEVRDLRLGQPPSDTYNSSRWITIVYVRGSQWKVLHMVALTDEIYDLWVQTLKSLVSVTTDKHVSDVTPADPDLIWIRQLWPIGSKVIDREKAEALCTQIGLQIPTQVAKAYHGSLDISTFHQLIKDCQTRPEIDKIYAELTKDGPLDPTLVNQFLTDTQKLADTKGIFEKYLSGSDRVWSLSSLINFLCSADNSSNMPQDMGQPIQHYFISSSHNTYLVGEQWRGESTVEGYIRVLLAGCRCVEMDVQSGDNEPVVYHRKTLTSSVSVRDICRAINQYAFVSSPYPVIISAEIHCSYEQQNRLASILKDVFGERLVTAPLAGPCTDLPSPEQLMHRILFKAKPPKAEPKSPKLSPIFPAPDSATSSTESDSGFARLTRRLSIQGKTEKPDLFSKDLADLLVYTTGVKYKGFSKLNEYATKEQFSVSERTASKIVRENKQDWIKHNFNHISRVYPRGTRLTSSNYDPTIAWSAGCQLVALNWQTLDEGFLLNHAMFHGSTGYILKPLALRSKITETLKRYRIKVDIISGQRMPLSPDLYVEITLKPSSTYSSWSSASSSSSSSSMSPGFIPGSLNGEQNISLPPSPMSPTKFRRTPTSQGITLNPHWRMNDNIVFDLNITPAELSLNFLHLEVKNRQSGLIAQHIRPLNLVPKGYHHLPLYDGMMSRFVFATLFTKIEIDQLEHNIHSPTFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IDX3</accession>
    <name>A0A1B9IDX3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Solute carrier family 30 (Zinc transporter), member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_00937</name>
        <name evidence="13" type="ORF">I206_100387</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014850.1">
        <property type="nucleotide sequence ID" value="XM_019152712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IDX3"/>
    <dbReference type="STRING" id="1296096.A0A1B9IDX3"/>
    <dbReference type="GeneID" id="30169306"/>
    <dbReference type="KEGG" id="kpin:30169306"/>
    <dbReference type="OrthoDB" id="9944568at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000021">
        <property type="entry name" value="Solute carrier family 30 (Zinc transporter), member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000024">
        <property type="entry name" value="Solute carrier family 30 (Zinc transporter), member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 63C, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="12"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="327"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="11">
        <location>
            <begin position="404"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="140"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="190"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="511"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="207"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="257"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="286"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="520"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCF53631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC66485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="531" mass="56978" checksum="747D4124E3615CB0" modified="2016-11-02" version="1">MGISRSARILTLLVIDTVFFFIELISGYAVGSLALVADSFHMLNDVLSLVVALYTIKLATSPSSSANSYGWQRAEILGALINGVFLIALCVSIFLEAVGRIVTPPEISNPKLIVIVGSLGLLSNIVGLFLFHEHGHSHGHSHGAIALPDDDDDNDEEVREDSVSELFQHPAGTRAQIIETAQEFGYGQNQASRSLDNGIPKIMSPPSHHHRALSNGRRSHRNSSISRSSESRKGSASKVPPVAGQNDTLPPFGGLNDGNSSTASSATIVTQSAPAAPAKSNLSHSNSHDHDHEHDHNDGNGNGKKLATNASDAENGHADEHDHGHGGHGHSHGSMNMQGVFLHVLGDALGNVGVIAAGLVIWFFEGRWTLYFDPAISLLITCIIFSSALPLCKSASYILLQGVPSHVSLDAVRKSIVNVDGVDSVHELHIWQLSESTVVASVHVMIVPGQDYMDVANRIRQRMHGHGIHSVTIQPEFLTDEEALSTNGEACLIRCPPDQCQGDTCCPPINAKSGDEEEHDHDHDHDHDHSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8KXP7</accession>
    <name>A0AAJ8KXP7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial inner membrane protease subunit</fullName>
            <ecNumber evidence="8">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_100273</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase S26 family. IMP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="8"/>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058265.1">
        <property type="nucleotide sequence ID" value="XM_070202164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8KXP7"/>
    <dbReference type="GeneID" id="30169421"/>
    <dbReference type="KEGG" id="kpin:30169421"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052064">
        <property type="entry name" value="Mito_IMP1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383:SF16">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383">
        <property type="entry name" value="PROTEASE FAMILY S26 MITOCHONDRIAL INNER MEMBRANE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S26" evidence="9">
        <location>
            <begin position="27"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC66372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="235" mass="26767" checksum="7D6AFAB7DB24210D" modified="2024-07-24" version="1">MASSFSRFQHVFSRYRPPPLLPTTIRTIQILATLHLISTTLVELRICTGFSMLPTLSQHGDCVVVSPLPYWSPFTEKHKDKRPKRGDVVVATSPMDSRQTVCKRVLGIEGDMIEIEPRRGGQRKWIDNSGVGFMVDIPQDVELEHEENKEKHITYKDLSIKPKRNGENQWIKIPKGHVWLVGDNLSNSTDSRKYGPVPVAMVKGKVLARIYPNPTWIENNLKEIDQQTSNPQMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8KZQ4</accession>
    <name>A0AAJ8KZQ4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cell cycle control protein cwf19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_100651</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWF19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058349.1">
        <property type="nucleotide sequence ID" value="XM_070202248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8KZQ4"/>
    <dbReference type="GeneID" id="30169043"/>
    <dbReference type="KEGG" id="kpin:30169043"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006768">
        <property type="entry name" value="Cwf19-like_C_dom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006767">
        <property type="entry name" value="Cwf19-like_C_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF5">
        <property type="entry name" value="CWF19-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04677">
        <property type="entry name" value="CwfJ_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04676">
        <property type="entry name" value="CwfJ_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cwf19-like C-terminal" evidence="4">
        <location>
            <begin position="653"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="Cwf19-like protein C-terminal" evidence="3">
        <location>
            <begin position="785"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="301"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="488"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="548"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="313"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="347"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="447"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC66746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="914" mass="103335" checksum="DE01C78836B1C829" modified="2024-07-24" version="1">MGESSRRERDRSRSPSRKHREHKEKHRGKDSGSSSKHHSHKSSKHDDDEDRHRKHRKEKIRDRDETEEERKERKRSKKDKKRSDENGLRVLDDDYDESMWVEKETDGISTSNIPTSDSLALQSNPSNPPPKVPLPHSTASGTQMRERDSWMLEPSDVTTASIPIPSRDVPRNTGSGGLTEGYGDEVASNRNLSGGMDFFEGLGTVHERKDPKADLPDPSKLVVDKRFELNTQLLEGKHIDDYETKEKKITPGGPGYQWRMMKLKRLYEQAEEQGRDIEDVAMERYGNLDEFNEAVEERRVLDARESRRKSRRGPGGSDGFSTPGGGSSGFRTPDTSGRRFMFTNPAGGEEFGSSRPSSRGGFRRPGEEGDSFVTPSGRVDELRRRESDNSRTPKERTIGFTSHTTGAPKVSTPIPSVFTPTALTRSGSGYPFNTTAEKSGAGLEAGQVQNPDSTSSRPPLTTEQLNKLQAKVIRAKLMDEPNAVSLEEEYESERIRSEQAAQGGLWEGTTDSNGLQGQFGRTDERGNRVETQVLPTLDGRGRLYDVGLGQADDLESRPGNKRKKVEKFETRDKEGNVLRYNADDDTQSLGELVRQEKFGAGSSDQKNMDAEMAAAIGRDAKFASDVDYMDENVDKLARRKMKSDAMKRAFAINDYARTKKAMDDCPFCYQDERNPLAAIVALGTRTYMCCTQFEELVPGHCLIVPIQHHLSMLELDDEDWDEVRNFMKCLMLMWSKKNYGVIFFETVLTFKFQKHTYIEAIPIPFELFEDLPQFFKESILNSEGEWTQNKKLIDFSLKKGGFRNLMVSNLPYFMCQFDYKGEKGFGHIIEGLNESGSGIGKSQGEENQSDLGGVAGKEDEFPRYFAAEIIGNLLDLEPRKWRKPKKIDYNLNKERARKLGEQFQPFNWTIGQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L017</accession>
    <name>A0AAJ8L017_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Meiotic nuclear division protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_100520</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the MND1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058322.1">
        <property type="nucleotide sequence ID" value="XM_070202221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L017"/>
    <dbReference type="GeneID" id="30169176"/>
    <dbReference type="KEGG" id="kpin:30169176"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040661">
        <property type="entry name" value="LZ3wCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005647">
        <property type="entry name" value="Mnd1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040453">
        <property type="entry name" value="Mnd1_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18517">
        <property type="entry name" value="LZ3wCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03962">
        <property type="entry name" value="Mnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026991">
        <property type="entry name" value="Mnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mnd1 HTH" evidence="7">
        <location>
            <begin position="15"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine zipper with capping helix" evidence="8">
        <location>
            <begin position="145"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="80"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR026991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC66617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="199" mass="22178" checksum="918C61062D640E50" modified="2024-07-24" version="1">MSKRGLSMEEKKMKMLEIFHETAEFYSLKELEKIAPIVQSVKEVLDDIISDGFVQMDKIGTGNYFWSLPSAAGATKQALLAKNKKELEAINEKIKEVQADIEDAEKGREDTPDRRNLIAQLNGLNETSSSLKKELSAFGAADPIKYEKKSKAIQVCKNSAVQWTDNTLILLTHISNSGVDTEGIKANLGITDEWEDLQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L0V6</accession>
    <name>A0AAJ8L0V6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Chromosome transmission fidelity protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_101896</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058573.1">
        <property type="nucleotide sequence ID" value="XM_070202472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L0V6"/>
    <dbReference type="GeneID" id="30175382"/>
    <dbReference type="KEGG" id="kpin:30175382"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057646">
        <property type="entry name" value="WD40_WDHD1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022100">
        <property type="entry name" value="WDHD1/CFT4_beta-prop_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048591">
        <property type="entry name" value="WDHD1/CFT4_hel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932:SF10">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20946">
        <property type="entry name" value="Ctf4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12341">
        <property type="entry name" value="Mcl1_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24817">
        <property type="entry name" value="WD40_WDHD1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1 first WD40" evidence="9">
        <location>
            <begin position="15"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="138"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1/CFT4 second beta-propeller" evidence="7">
        <location>
            <begin position="399"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1/CFT4 helical bundle" evidence="8">
        <location>
            <begin position="699"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="790"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="795"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="819"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="836"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1008"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1019"/>
            <end position="1034"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC67977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1059" mass="116109" checksum="6BD894F1BC026927" modified="2024-07-24" version="1">MVEADSSSITSIPCHLSGVTRVCFSPDGSTIFTGGSDCLVRIHKADQPDSEPGFHDNHTDAVTSLTCSKTNLITASEDNIARIFSYPENEFTGFLTRSSGVPIRWVSVDNSGERVAVCSDDLLVKIVNVQDATKVSLLSDNNKSVRSATWDPSGKYLITASCDGKLKVYDTTSDTPICLKIMEGVIGSSESESSVSCYAAWHPAGNYFAVPLRTNDIGIISREGWSKQTTFTHDGPKTSIGELAWSPNGKYLASSSNTTIYIWATDSRQVIAKYSNSEGAISGLCFSPKSNLIAYTSLDGSFHRWSNPIPDNLPNPYSTAREEAKNLDKLLDDEFGDDEVDMEDKGEDLDNDENDLFGDDGWIVDDEDGVKGAYGKDDDERKWSNGRTEVVNVTKAQASFTPGSTEFKSKKRYLAFNMIGVIDVTDQETHNVVNVEFHDKSTRRGYHFQDHNKYTMASLGEQGVVYASKAESNSPSSVYYRPYDSWASQSDWSITLPPGEDAIAVATGGGASAEGGLGSVIVATSNGYVRFLTASGLQRYIWRLGEDVVSMAAGRDKVIVVHREGGTSLDGCQNLRYSLMELDTFEILQEGRVPLPKKVTLKWLGFTSDGVPAIYDSAGLLSTLDRYRRPGQARWIPLLDTVSLRKEGKQEGYWPVGVTSTHFSCIILKGSEKEPWFPRPLIQEVEMHMPLLNMDNQQGKLEESLVRGHLVLSTLTDSVDPDIDYQIKEKEVSLDKEYLQLVQIACKADNLQRALDVARLMHNPGTIEAAAKVAAFYHLPGLQERIVAVKTEKERRKREKKNRPRAAEYTPSSLPIPPSTNGSASTSRGFTSDFAPRPGGSRRSFGGVNRDATPVNSAPKETYIPETPGEDDLNTPAPEDYVEEEQSVSPVAKRRKLDDDEFAVPQVKQKDDFPFPNSAPKNPFAKKAMGSNPFAKSSGGSKPLDQVKSTSFFDRVDDINLSGAPKVSAKPRNPVKVKGKDTNGLGKQTTLFGAGVTKQRPPPAPLPKSTTDSFVSTETEGDYEVTQLEEDEETVESRPGILEESNVQETLSPGEMEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L1D5</accession>
    <name>A0AAJ8L1D5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Arginine N-methyltransferase 2</fullName>
            <ecNumber evidence="10">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I206_101127</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that methylates the delta-nitrogen atom of arginine residues to form N5-methylarginine (type IV) in target proteins. Monomethylates ribosomal protein L12.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="10"/>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058434.1">
        <property type="nucleotide sequence ID" value="XM_070202333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L1D5"/>
    <dbReference type="GeneID" id="30168568"/>
    <dbReference type="KEGG" id="kpin:30168568"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019702">
        <property type="term" value="F:protein arginine N5-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000430">
        <property type="entry name" value="Arginine N-methyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017408">
        <property type="entry name" value="Arginine_N-MeTrfase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051038">
        <property type="entry name" value="RMT2/GAMT_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026480">
        <property type="entry name" value="RMT2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32379">
        <property type="entry name" value="GUANIDINOACETATE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32379:SF1">
        <property type="entry name" value="GUANIDINOACETATE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038148">
        <property type="entry name" value="Arginine_N-mtfrase-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51559">
        <property type="entry name" value="SAM_RMT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="51"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="RMT2" evidence="12">
        <location>
            <begin position="139"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC67220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="391" mass="43781" checksum="CB620DB0787B3A59" modified="2024-07-24" version="1">MSDVKMEDGQIPFDLITLAHQLLISSQNESLSEVKKLLDQGAPAWYQDDALGWSALHYAAERREPKLLEILLQGGAIWNALDRWGRTAGEICLSLGDEKGWEIIRNEGIRSEMLHHALAGPSSPQSDSSTNIKLKAEDKTSAGDNLTFLKSQLTWNIGDDGKERVLDADGNGVMMGWEEPLMIEHVRYMTNDHPNAQPSAEGMTILNVGFGLGIVDRLFQQTQSSSHPKPLNHHIIEAHPQVLQYIRDKGFDKIPGVKILEGRWQDFLQDPEKLGEVLEGTPGGMGYDAIFVDTFAEGYEDLKAFFEVLPDILEPENGIFSFWNGLGATNATIYAVSSGLAELHLEDVGLDTKWYDVLIPDSLREEVWKGVRRRYWELPGYKLPIAKMKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L2C3</accession>
    <name>A0AAJ8L2C3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_102186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC68263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058623.1">
        <property type="nucleotide sequence ID" value="XM_070202522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L2C3"/>
    <dbReference type="GeneID" id="30175090"/>
    <dbReference type="KEGG" id="kpin:30175090"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022036">
        <property type="entry name" value="DUF3605"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35020">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-INDUCED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35020:SF2">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-INDUCED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12239">
        <property type="entry name" value="DUF3605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WWC68263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="326" mass="36927" checksum="A03150AACC1BC4CD" modified="2024-07-24" version="1">MPQFSEVIYLNDRRYPGPNAHEASKDISGLPTQEELDAYPRMFTWGELKEIIVSGRLEGLMRNKEMQVRYNIWTKGIKEKYGSTENYLRQGRLPFPQSTPESRFDDPIPSSAVPHEYLKYDLDLSLDSSKYAVLVNDWPYNIPYGVRHFCVWSKVPIAHPSLVNNDSTLWAKIEEEGLAGFTGIIPIPAPDKPSSDPSCVSSIPRTNVSVNGDSKGKQLIHPQGWGSTDLSEFGEDTWLSVDLKFGGTDFRKWAGVQYETPGGEEVGKMVNGLWDRRGWECLWFVNPPRLQSVPGLSHFHVFARRKTPEEIDAAELIWGTGEKHVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L411</accession>
    <name>A0AAJ8L411_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal lipase-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_102689</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012199.2">
        <property type="nucleotide sequence ID" value="XM_019154796.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L411"/>
    <dbReference type="GeneID" id="30171411"/>
    <dbReference type="KEGG" id="kpin:30171411"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00741">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="2">
        <location>
            <begin position="276"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC68755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="444" mass="49054" checksum="AEE48BF49C283DA4" modified="2024-07-24" version="1">MNRSSPSRLSVSVTTCPSLSFFFAITPKHHEKIYAGFDEHKLQMTTMLCTIAALLLPPLLITAIPSLSTISILSSEKSAVGELPSGKTLLSQSDIAEIGRLATAINFGYCPKEDKLQPHHPSNFVIQARESHHRHVHTFSYTPSNAQESNVVVSSDDVQYIDDRLIGGQMRWYISHTPSTQTLTLTLSSLSSSDDLLDLLESQTKNNETLIPLASTLFPFEHLPPDPFSEFPSIYHSYLNAISSHGNSALSTMLELIENPPPTLNSHRNILREYVASLVESHSAVQENPIKKVEIIGHGLGSAVGLLIALGLKLELDSTSIREKDHLQITANLLGLPRVGNEHFGKVVRALLDTKEKRTNLQINRITSYLDTITHLPEKHLGLTHHSDDEIWVGPDPRFVYFCKSDETDGCSGHVELGKTSLMDHMGPYDGIRIDPLCKVGSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L5X8</accession>
    <name>A0AAJ8L5X8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_103952</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
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    </reference>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <source>
            <dbReference type="EMBL" id="WWC70008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="572" mass="66747" checksum="6B94307054831ABF" modified="2024-07-24" version="1">MLIQDTINYKIQKSPPINKIENNKNNQEHPIEKFDSHLIEDILINLSIKDLISCSEINKFFHNNIREIPSIQFKLYKKLYKVFDFDNDYNNNNENFDFNFKINSTKNIINLIEINRNLIRLTPRILKLNFKLNLNLNLNSKEKELIFKIQENYLITIPKYIKKDLIIIIDIQGIIHSISFNQFYKNDIILENFSQGIEIPFEIWEKRIENEIRINLVKNSLDKEILIVELSKGKWLIYDWKTTELLHEFPPDPKITWGSLYGSIINHQGLLIGLDIPSLPWMPNSKPKDACLAVFNLCCKPVCPIFENHPMVFLEIPIKNIQLSILFKILNQIPKNKKIIVHSEGLPILHETFNPFLIRITIPFKIIIGPNQGSISELNIVIPIKQLESIKMDNLQKVWHKGRTWRRSSNPLDGVNSIPFEKYYQRCHFWIDDYNKIEKNSINSIDYQVGQKIIKIDKDLMKKTGKLKLEISDFNHLKITNHVNLYGALRGLELDKIPEDGNRPAKPRSVPQSYKLSETAATTHLSARFKCSGILPLGMPGEIEKVVCDEKGQKLIIQQKNQDKLWILDFGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ8L6K2_9TREE</name>
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        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_103728</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
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    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_070202819.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="kpin:30169640"/>
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        <property type="component" value="Chromosome 4"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Related to Cleavage stimulation factor"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
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            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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        <location>
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        <location>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="WWC70265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
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        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
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    </dbReference>
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        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
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    </dbReference>
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        <property type="entry name" value="Lactamase_B_2"/>
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    </dbReference>
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        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="198"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC70265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="524" mass="59582" checksum="E3EEBEB419CA75C6" modified="2024-07-24" version="1">MTHPVISLIAPSASLLRDHHGPFQSSRAKPVEDDCSNETRHKPKYFRNPWPSYRTASLKDAYLAYQLGAAIALHPENSPGSSKLKRSRSRSEVNLSYEPDQYELDESDEDNPREEDVSLRAENSTRKIPKKIYVRPELSKIWDDDEIEDWRDPPVEVVTPTWLSRADQISQKEKVTWLGHAGVLVEVPWKGRDGFAGILFDPIFSYRCSPTQSVGPARYLDPPCKVSELPDIHICCISHDHYDHLDYYSIIDLWKYHQSTIHFVVPLGLKQWFTASGIPSTRVTELDWWHETFVSFPNSSPYSDTDPTYPPEESENEMRVSSETIHEPSSLNLKIAFTPAQHRSGRGLLDHMTTLWGSWCLGVVEERDKDKVDQRGMRGWEGFKIFFGGDTGYRYATAPEGDDDAICPAFKEIASHYSPFDLSLLPLSTGSSLPFLRTMLSLSLDQYTLTSSLHCSPQDSLEIHRILESKRTLGIHWGTFCDEDESRGTRVDFGRSRRSMGISGDWNDEGCFVVGDIGETFVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L882</accession>
    <name>A0AAJ8L882_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Immunoreactive mannoprotein MP88</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_106466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059424.1">
        <property type="nucleotide sequence ID" value="XM_070203323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L882"/>
    <dbReference type="GeneID" id="30175640"/>
    <dbReference type="KEGG" id="kpin:30175640"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042460903" description="Immunoreactive mannoprotein MP88" evidence="1">
        <location>
            <begin position="20"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC72504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="36214" checksum="FE7B73A2D9FF4E29" modified="2024-07-24" version="1">MIASIAVGAAALLAGVAQAQVTATGTMGPTNPAQATLGTAVNQTSMARLVSLNAIDDFCLFAPPEANSVIGETEAEEVAWCVQARNNARQIPDGTFTSVHFVKTPLYWQIQGLGDLTKLNIASGDEGGELDPHGATGLGNPVGGNVTTNATGTDVHYEEWMNYMSYQQFCLRICIAENSTYSAALMCQHTLDEMGCNWVMPGDYTDNSFTECDGDSAYPPGLYPLSNGSTSTFQQRYTGTYTDGSGSVGMWTQGQTVTPQTAYSTPATSNCVTYSTIGNGLAAVATGSSNSSSSSSSASASGSASSAAASGSAKAASGSGASSSKSGALPLAAGNNLFAGVFSLLAVFASAGAFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L9L4</accession>
    <name>A0AAJ8L9L4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carbohydrate kinase PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_106726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007751.2">
        <property type="nucleotide sequence ID" value="XM_019159079.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L9L4"/>
    <dbReference type="GeneID" id="30175754"/>
    <dbReference type="KEGG" id="kpin:30175754"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47098">
        <property type="entry name" value="PROTEIN MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47098:SF2">
        <property type="entry name" value="PROTEIN MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="2">
        <location>
            <begin position="231"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC72762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="458" mass="50192" checksum="2DB8857D7395B2A7" modified="2024-07-24" version="1">MNHSQAGPSSPRLAPPTFASIGTVLIDAFDSPPRPILDTVPSPDQSFKTSSARHDTQGAGLPTPPTPPTPEKNESSANITQATSINSTQLPRANPPIRPLRAQNYLATPITSPATSSGPSTPQLSLDDSSEPNLDEIYEMLGGGALYALVGARLWLPPSQLRTLVDRAPESENSELPSDAEDKLKALGEDIWVWNRAEGSKMIRARIRYEGDVRFFQPIVQARHRTMAQIYQSPLFGAEYLHISPPYSPENVFNLLEEMKTIEENAENQNWKPKIVFEPTPPSCHPGQREWLEKIVPNIEVLSPNHEEIFSILGIPLIDMSSMEFISTVEGIIKYFLDEIGIGKDGQGVMIVRCGKLGACIGTKQKGLRWCPAYFQGKDQVKVKDVTGAGNSFLGGFVAGLSLANGDPYEAVLHGTVSASFVVQQFGLPILSSIEGVERWNDDSPQSRLEELRKRLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L9X9</accession>
    <name>A0AAJ8L9X9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L-serine ammonia-lyase</fullName>
            <ecNumber evidence="5">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_105774</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="5"/>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC71815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010126.2">
        <property type="nucleotide sequence ID" value="XM_019156324.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L9X9"/>
    <dbReference type="GeneID" id="30172963"/>
    <dbReference type="KEGG" id="kpin:30172963"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000040">
        <property type="entry name" value="L-serine dehydratase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF2">
        <property type="entry name" value="CATABOLIC L-SERINE_THREONINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="11">
        <location>
            <begin position="34"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC71815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="350" mass="37555" checksum="4E32D87304A7DA7C" modified="2024-07-24" version="1">MTVMPLTPPAEPLLELELTKGFIPKQTYPCPWIETPLIESAPLSKLAGCRIFLKMENFQPSGSFKSRGIGNLVRCAVERSSSTEPLHFYASSGGNAGLGCVTAATTLKQKSTVVVPTITKQAMIDRIISAGATQVIKYGNTIADADEYLRNSLLPDDSQGVYVPPFDHPDIWNGAESIMHEVHNELNTLPDGIICSVGGGGLLIGICQGLDRLSGTTSRTQVIGVETLGCESFSQAIIAKEVVTLPGITSIATSLGCTRIAARALEYGLRENVHSALVSDKEAVDACIRFAEDHKILVEPACGATLALVYSGRLGQIMNLKPNDKIVLVVCGGSNISIDMMYKWKKEYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LA59</accession>
    <name>A0AAJ8LA59_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_106091</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010446.2">
        <property type="nucleotide sequence ID" value="XM_019156644.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LA59"/>
    <dbReference type="GeneID" id="30173284"/>
    <dbReference type="KEGG" id="kpin:30173284"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01417">
        <property type="entry name" value="Ribosomal_L19e_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.240:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1650.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01475">
        <property type="entry name" value="Ribosomal_eL19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035970">
        <property type="entry name" value="60S_ribosomal_eL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039547">
        <property type="entry name" value="Ribosomal_eL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023638">
        <property type="entry name" value="Ribosomal_eL19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000196">
        <property type="entry name" value="Ribosomal_eL19_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015972">
        <property type="entry name" value="Ribosomal_eL19_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033935">
        <property type="entry name" value="Ribosomal_eL19_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057259">
        <property type="entry name" value="Ribosomal_L19e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057260">
        <property type="entry name" value="Ribosomal_L19e_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006343">
        <property type="entry name" value="PRK08570.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01280">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25476">
        <property type="entry name" value="Ribosomal_L19e_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01416">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48140">
        <property type="entry name" value="Ribosomal protein L19 (L19e)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00526">
        <property type="entry name" value="RIBOSOMAL_L19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL19" evidence="6">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="164"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC72131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="195" mass="22553" checksum="393348772F5C1AFF" modified="2024-07-24" version="1">MVNLKQQKRLAASVAGVGQRKIWLDPQEAAEIGQANSRSGVRKLLKDGHIIIKPTVIHSRARTRDHAAAKRAGRHTGFGKRKGTAEARMPTKVSWLRRMRVLRRLLKKYREGGKIDKHLYHTLYLEAKGNRFKNKRVLMEHIHKAKAEVLRTKHLAEQQEARRVKNKAMRERKAQRLAEKRQGITAVEQEDEVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LAZ6</accession>
    <name>A0AAJ8LAZ6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_106819</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC72855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059511.1">
        <property type="nucleotide sequence ID" value="XM_070203410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LAZ6"/>
    <dbReference type="GeneID" id="96955777"/>
    <dbReference type="KEGG" id="kpin:96955777"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="20"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="20"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC72855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="67" mass="7152" checksum="4D12373FDB9658E3" modified="2024-07-24" version="1">MQTNATASSSSPTVKIPAIRRPWTEEEDAALIAAVKQYGSARGPGSAWGIIAKAVGGHRTNKDCWKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LB86</accession>
    <name>A0AAJ8LB86_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_106777</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059499.1">
        <property type="nucleotide sequence ID" value="XM_070203398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LB86"/>
    <dbReference type="GeneID" id="30175704"/>
    <dbReference type="KEGG" id="kpin:30175704"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC72813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="39116" checksum="A7A45BC047D10B40" modified="2024-07-24" version="1">MTIAPSIPLPGLSRVAVLGAGGASGLAAVAQLLDKGARPDQIVGYEARSTAGGVWNYDGDAGECQAIWSEDGTLLLKTEKEIYDAGRNGPTAVYDELRTNLPAECMTFRNAPHPDGTPIFPTHRGIASYLQNYAKDRDHIVVTNGHFNVPFIPSVPGLNTWRGKLLHSRWWRDAKSVRGRNIVVIGSHASGTDIARDIALDDEASQGSLRKIYQSAREKQKARPNEDQEEQTLYPNTKWKDHVEIVPVIEKVEGDKIYLKGGRILEDVDTLLFATGYLYSKSTPEERALSAGPANRPINLDVTDTFYAPDPTLSFIGLRDLNIGHPQEFENQDDWLRAIGEVSANVDLPTADFIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LBB4</accession>
    <name>A0AAJ8LBB4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycoside hydrolase family 5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_106085</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059336.1">
        <property type="nucleotide sequence ID" value="XM_070203235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LBB4"/>
    <dbReference type="GeneID" id="30173278"/>
    <dbReference type="KEGG" id="kpin:30173278"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046557">
        <property type="term" value="F:glucan endo-1,6-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF43">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="5">
        <location>
            <begin position="179"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="493"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="497"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="510"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC72125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="768" mass="81556" checksum="39BF50889FE19A98" modified="2024-07-24" version="1">MVLIDLQKVLSTLGLVSSIAKPIPVVGGLAGGLLDSAGGVVSGVASGGALNGLLGGSANGIVAAVNIGDGNFSTASTDPSSDDSSGSTSDITAQDACSITPYSPPSPVLLESFAPYDANKALIYRYRQQQSVNLGSWFVQEQWMNPSLFSCASGNKQAEFDVANGWGSVDNARQVLERHWDEWITEDDFKYLASIGINTVRLPIGYWSLGPVYCQGTAFESVSAAYTNAWPRVVRAINWAEKYGLGVLVDLHGAPGSQNAQAHSGVSDGQQNLFNNPTNVQLTINVLTYLTQQLVKVNNVVGIQILNEPSNVDSLPSFYSQVLGVLRQVSPEAAVFPFYLNDAFDMSRFADYISTRKDFVVLDHHSYFVFGDANSQATPASQLVASLQPGQGSLSNQMVGAATEGRRNIVIDEFSCALSTQALSNSQDQAGDRRQFCTGQMESYTNATAGYSFWSYKTENCASDVNWCFTSAVGNTLPSTFFSYPKTTIQAIQGGVPSSPSQDPTTDTSFLSFGTSSPSNDNDYAPPTTDDWLAAMGASDPEYDQVTEALATTEFDAVSDSTAAAASAASDEIAPDSSMTTTTLWAAASTPSMSISGSDDVAQAAFAVAPLANAATISSSRQQLSQIGAKKRSLGLTSLPQRAFLLSSSLAKHRFVARSARAHSRRHANVVRRDGADGESAVLYTPEQAAIAKGYSDGWKAAKAFATFNNSRLGFTGQFISDALNAMDNKIVSGDEGFYKTWFRTVKGLADGEVQVIKLLAMQAEGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LBI4</accession>
    <name>A0AAJ8LBI4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_106927</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC72963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059529.1">
        <property type="nucleotide sequence ID" value="XM_070203428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LBI4"/>
    <dbReference type="GeneID" id="30173898"/>
    <dbReference type="KEGG" id="kpin:30173898"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000196">
        <property type="entry name" value="Cell division control 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="92"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="429"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC72963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="470" mass="53354" checksum="8C677FE96DA5A247" modified="2024-07-24" version="1">MSEGYYEHSNGNGTTNGTYGEGRSNAASPNGDSLHNSRAISPSGYPVKTEPGLNGNANAGSVQAQQPARKKLASWVGFSNLPNQVHRRSVRRGFQFVAMVVGESGLGKSTLINTLFETKLYQPKNVPAPGEDRGQTVQIESISAEIEENGVRLKLTVVDTPGFGDFVNNDESWKPIVDNIEARFDAYLEQENRVNRLKLVDNRVHACIYFIQPTGHSLKPIDIEFMRRLHTKVNLIPVIAKADTMTDDEIVLFKQRILSDIAHHGIRIFQPPQYENEDEETIQENEEIISKVPFAVVGSDTLVNSPDGRQVRGRAYPWGVIEVDNEDHCDFVKLRQMLVRTHMEELREHTNDVLYENYRTDKLKAMGVSQDETVFKETNPAAKQAEERALHEAKLAKMEAEMKMVFQQKVQEKEAKLKQSEEELYLRHREMKDALEKQRQELEDKKRRIESGRPLTPEKGSQKKRFGLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LBU5</accession>
    <name>A0AAJ8LBU5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">I206_106935</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the diacylglycerol acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="5"/>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC72971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059531.1">
        <property type="nucleotide sequence ID" value="XM_070203430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LBU5"/>
    <dbReference type="GeneID" id="30173891"/>
    <dbReference type="KEGG" id="kpin:30173891"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07987">
        <property type="entry name" value="LPLAT_MGAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007130">
        <property type="entry name" value="DAGAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317:SF0">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03982">
        <property type="entry name" value="DAGAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="178"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="80"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="WWC72971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="510" mass="57764" checksum="B427599A1A07C9CE" modified="2024-07-24" version="1">MSATIPTSSSTSTSTLLDIPKSKTRSESLSTKHGPLAPHAFESHGPSPVQGDIPNGHMSKDESLRRRNLAKRGIGIDESGNIHKSIENEEDHDDFLDLNDLDNRDEEVDGEEGEDEFKGHRRASSLSEASRKVREKIRSPLVSTIKLDELRDTLEIGIEKKFAPLSIPPHRRLQTAAVALWALLVPICLIIFLLCISFPPTWVIMIPYLIWIQFDTAPDWGGRPKEWARRFFFWTYFAQYYPCSIVKEADLPPDRPYLFGYHPHGIIGMGAFATFATEGTNFSEYFPGIKPHLLTLESNFKIPFYRDILMFHGICSVAKKACANILSRGPGTAIAIVVGGATESLSAHPGTADLTLKRRFGFIKMAIREGADLVPVFSFGENDIYEQLANAKGSWLYKIQKNFQKMFGFTLPLFYGRGLFNCMYESDHVFQAYELTDDVDACKDNIGLMPFRHPIVSVVGKPIHVKKDAHPSDEYVQELQHQYIEELMRIWDRYKDLYARGRTKELTLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8ML33</accession>
    <name>A0AAJ8ML33_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_101319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058467.1">
        <property type="nucleotide sequence ID" value="XM_070202366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8ML33"/>
    <dbReference type="GeneID" id="30168374"/>
    <dbReference type="KEGG" id="kpin:30168374"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="189"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC67411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="396" mass="44744" checksum="3A6D50E518AC4FB1" modified="2024-07-24" version="1">MTNHLIDPSLWPDLEAKARLEYKPNQGLAFGPFLFGYAADGFAFGFLALQILQWYTLSYRTETRIVRAIVIWTLLLSTLYTALSIRYMLNLFAYGFDVYRNFYNFSWVSTFLLLSGFIQTPISCFFAHRAYIFTGRSKAFAWTTFPIIVVTLVICITLKATAPPVWTEHLLAQSRLTMTLILTWLALTVVRDTIISGTITWALVSGKTDVQAFEKTDKWAKKAVIIFIEAQYAATLFALAFVISFIAIPRSNLTAFFMCTPKAYAVTVMGALNGRILFKRDLIPANAVQLKHPFFGVFNSCASGISCLLPHTNKRNQNQNQSDSINATQTEIHVETETIQQTSQLEPLQVKQSVNRDPKPYSSPYSLDLGGMSLHDGVDYYGHRSRKRDTNGEHPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MLU4</accession>
    <name>A0AAJ8MLU4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NADH kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_100326</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058275.1">
        <property type="nucleotide sequence ID" value="XM_070202174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MLU4"/>
    <dbReference type="GeneID" id="30169368"/>
    <dbReference type="KEGG" id="kpin:30169368"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000009">
        <property type="entry name" value="Poly(P)/ATP NAD kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF26">
        <property type="entry name" value="NADH KINASE POS5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC66424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="43051" checksum="2069CA2B5697E133" modified="2024-07-24" version="1">MYAVTSLVSPLVRASIRGIKRKGPLYRSIHQLKHLPQPTQKEIINKPRLQPCNWPKAESSAMGAARFSPVHELSEWTSSPTTLLLVQKKNDARTTKAMGDILSYLHSTYPHLKLIVEPHTAADHPDFGDLIVTSGDEDLLPLHTNLVLTIGGDGTILHVSNLFSQGECPPVLSFSMGSLGFLLPFHIDSMKSTIRNTLNGPVSVLNRMRLACKPLSVKGEPLDRCTKSVGDAGWQVMNEVTLHRGRHAHLTVVDAYFDGQHLTEAVADGLLLSTPTGSTAYSLSAGGPISHPETDTFLLTPIAPRSLSFRTVILPGRGSVQLEISPLARSSAELSIDGKEVCLLNPKESVHITKSPYPIPCIERVGGESGWVRDINSLLQFNTGFRNKSLLGHGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MN76</accession>
    <name>A0AAJ8MN76_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_102286</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007641.2">
        <property type="nucleotide sequence ID" value="XM_019159347.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MN76"/>
    <dbReference type="GeneID" id="30176025"/>
    <dbReference type="KEGG" id="kpin:30176025"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WWC68361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="490" mass="56752" checksum="FE475F646C8A7FB4" modified="2024-07-24" version="1">MPELIERPCDYPECKMTVLSYNARCVWCHQIWCHEHIKQDCHKCASAQRVDNYDERLAELQRIQEVADAEELTRLLSQVRLNSAVFIEQAQELRPNRTCTMSIPPDYQTLKTSKWFAYCNVHFLITFDDGVKWLLRVRQNRSHRLPTALTTPVIKSEVATLMLLKSKGVPVPAAYLPPHLREKNDAQNMTDLDYFFYEYISGIPLHLPFKGYFSEIDLPEDQLEGFIEEYCKIKIQLSNLHLPYSKLGCIYPSGEGITEVGPIVSLGCFMNPTSPHFMGPFTTYKEMMLAKIDAALRYVKVNALQGGYTVDEYLWHLEMRELVAASKVLIAIPTELFIKHNDSKGDEMMVNEDGKIIGIIDWEWAYVTTKSDAFSTPHFFNRTFAYMKGSNSLSHAEDLLIECYKRHGRDDLAECVKEGKLYLRMERIGYYDPAFTKSGFREVFGEDVPKDFNPPDDDAGWRKYMLKRYEHDQTLKEVIDKYGTKQELAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MPS4</accession>
    <name>A0AAJ8MPS4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_103140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058788.1">
        <property type="nucleotide sequence ID" value="XM_070202687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MPS4"/>
    <dbReference type="GeneID" id="30170225"/>
    <dbReference type="KEGG" id="kpin:30170225"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000063">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.113, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC69203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="137" mass="15401" checksum="4DFB6DC015B81B9C" modified="2024-07-24" version="1">MSFSLPYKYITAEQLADLIKSKPTSELKEFAVVDVRDSDFVGGNIVSAINCPSDTFHANVDELVKKLESVPKVIFHCALSQARGPKAARIYAETRSHALPSSSSQEVFVLRDGFSGFQSKFRHDPELIEKFNKYYHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ8MQ98_9TREE</name>
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        <name type="scientific">Kwoniella pini CBS 10737</name>
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        <lineage>
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            <taxon>Tremellomycetes</taxon>
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        </lineage>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Murphy C."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
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    </reference>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="kpin:30169968"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="LAAT-1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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            <end position="60"/>
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    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="121"/>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC69457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="286" mass="31971" checksum="07A1D644474929DD" modified="2024-07-24" version="1">MKENKAAENVLATIGAALWALQAIPQVYKSYRTKSTRGLSPLMMCIWAASSLFFCVYVSSRHLAIPMVIQPHLTLIFLSIAWAQCLYYSYDYSFLKSLLYWVIWMTLAAVFEVGSIFGLLAAKRKGTEVPMVVYGYTSSALSFIGLLPQYYEIYRSKEVTGLSLTFVFTDIIGAIFYILSLFFRTRLDISAFVMYAVTAVMVIILVILALILNPRAAKQKRVQASISPTMPPLPTSNETGDIVVEEKPECNQSDQTRNPEPVTGLEYFVQENATHSYPAMPGSTLV</sequence>
</entry>
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    <name>A0AAJ8MQE2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
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    </gene>
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        <lineage>
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            <taxon>Kwoniella</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 10737</strain>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="kpin:30176109"/>
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        <property type="component" value="Chromosome 5"/>
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        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
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    </dbReference>
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    </dbReference>
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        </location>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC69848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="360" mass="39141" checksum="A2E18C39E61585A7" modified="2024-07-24" version="1">MRKYIISHREGIDGLVLQDDAAIPELRGPTDIKIRIKYLSLNARDLQIVSNDYPAPHDVPQDCVPVSDGCGIVEAVGEEVTLFKVGDKVAPVFPQGHHYEEDLALRTLKRGLGGAIDGVAADYFVCDQEDAVHIPSNFDCLQGSTLPVGFTTAWSSLFSHHPRLQAGQTVLCLGTGGVSLCAAQIALSAGARVILTSSSQTKLDKVSKLLKEQLPPRAPQNAIQTIDYSKIDDWDVEARKLNGGKGVDIVIEIAGRATLARSIRSTKQGGLVAISGYMSDYKPIPDHLIQEDLAKVILYSAANVRGVFVCNREDFKTAVSALEMGGVKPIIDKVFKFEDLKEAYRYMEAGRHIGKVCIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HSS0</accession>
    <name>A0A1B9HSS0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_07806</name>
        <name evidence="9" type="ORF">I206_103853</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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            <taxon>Fungi</taxon>
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    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV700118">
        <property type="protein sequence ID" value="OCF46324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC69909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019159491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HSS0"/>
    <dbReference type="STRING" id="1296096.A0A1B9HSS0"/>
    <dbReference type="GeneID" id="30176175"/>
    <dbReference type="KEGG" id="kpin:30176175"/>
    <dbReference type="OrthoDB" id="442863at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
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    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="C:ribonuclease MRP complex"/>
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        <property type="project" value="InterPro"/>
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        <location>
            <begin position="1"/>
            <end position="23"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF06978"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08170"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF22770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF46324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC69909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="782" mass="88223" checksum="DF66C4AA12FD61AF" modified="2016-11-02" version="1">MPKAPSAQAGPSKNNGGRPLKPIHKTVELLKKNEGAKRKGKGKEREILGDGVIGLIDEVKRLPGLIQVEKFAEARALEIYAFQSAIKIAAAQGSTRAFQSLPRHLRRRAASHNPRRVPKRLRSKAAAEIDSGDTIAKKHRKIARLRAKGTLRDHLSRTEQFALRQKNKTWLPTHLWHAKRYHMTNIWGYRLPITPTLKSFRPAYRAGRRKVIGFDTSYYGIIELEGQREEIISLLGRISAGKFAGIKYEDGSRVAKIMLYHFDAFPIHLIGEAEVIWQPILEGPNVRRVWLRLHPSIFNEVWDSMKIATSQLRHIGSSKIKELQIRDLRAGINSIDLIGPKAGKVLRRIMRLCRDEKSIKSQFFESLRYMDDPSHLTEGMMIGLKMHDPRLNFPPARLISRDIEDSDEGILRNNAIQPSSDLAQSSLWNSDIREDLSKAAYTKYQLDARRHRLGAPGTKLRLRSDDDRLPIMLYQRSITSSTSPSEGFYGFTILLPSGTWTQYLLSSMVYSGVLFGGIRERAIQHREAGIPSFPEHYGQTCKAGIEWEIRKGDKEKETHDRKPPGKRVEYGLIGTKDPWIANWDKVINGKSTEESIMNGSTKNKPWLLSSPFTAHLKSSLDPSALLKMLNAFRAQRSMSPISSERSQQMFETALVHVEVNVLGRGSPGDMAILSKIPLGERKLWIEAYEKAEKATAGEVSDLHKLGERLPDESEIIGYTSTGNFSLSRGQGYALATITLQGWVDLLKSAEEDNQIGWKGRTIVRVKNRDGALSRLAELKLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HSV9</accession>
    <name>A0A1B9HSV9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_07596</name>
        <name evidence="4" type="ORF">I206_102228</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894017">
        <property type="protein sequence ID" value="OCF46363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007582.1">
        <property type="nucleotide sequence ID" value="XM_019159288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HSV9"/>
    <dbReference type="STRING" id="1296096.A0A1B9HSV9"/>
    <dbReference type="GeneID" id="30175965"/>
    <dbReference type="KEGG" id="kpin:30175965"/>
    <dbReference type="OrthoDB" id="2565309at2759"/>
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        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="19"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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    </feature>
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            <begin position="640"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="519"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="392"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
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            <end position="460"/>
        </location>
    </feature>
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        <location>
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            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="673"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF46363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC68304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="698" mass="80800" checksum="108FD234BC40907A" modified="2016-11-02" version="1">MAIQPILPNEIDKQSKKLFNSNFKPSRRNKEPKPPSLSWSKLPPPAAEIDERLNFRVRRFKLWKEVNLELRRIVIDPNKRIHLRRYQSYAIPAVLSDQYRKLLPIPLPRLTKSGIATPIPEDEWSWSTPIRYQIQQPQYDSQNQLKSDEYQPVNEEQLTDEVKSLNRLVGQGGLLTPPLSAHEKDERALPCHRSNIRLSNPKINLPLERSKTGQYHDESNQSEREVAKFEKNSLTHILNSKITKESTSSPQNQYWLPPLPPSNQLPWYTKALSKKDRKVNYQKMLESKWILDQEYERRFRIGMKKLMELIMAWQNENTVPHNQWSKGDKVKWKDGVDINQIENIISFYRAIRKSSSNIFDYLDTNEIQQVPFRDRVHGWVKDEGVRKKRQKEKKEAKRKAEEEVKDNFSLQAIPPAPSQDQSQIDRSKQNIQEQSSNTLSSLTIPYSQTIRTDSHPSSSVSRERDKRSISQSKRAMEPFDISSLNHNTKDSNMENRRGNYDNTQNREIVESSHENQTSLSTLLTRLDALQRQKEELTLRLAQKDMTAKQAETFTDESANDYLDIPIRNNSFSTSSDQGKSSNAIEQIRFGSLNIDDDTALPISSDYPNSNFQLPSEQQIHISLPSSAFSRKRLNPDDRIEQSYSSSFNGDSVKHHDVDNFDDYPSIDGDTIDILSTTEEAGMQKDTQFSTLGTDSLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HT15</accession>
    <name>A0A1B9HT15_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ser/Thr-rich protein T10 in DGCR region</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_07639</name>
        <name evidence="2" type="ORF">I206_102269</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894017">
        <property type="protein sequence ID" value="OCF46405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007624.1">
        <property type="nucleotide sequence ID" value="XM_019159330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HT15"/>
    <dbReference type="GeneID" id="30176008"/>
    <dbReference type="KEGG" id="kpin:30176008"/>
    <dbReference type="OrthoDB" id="191601at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008551">
        <property type="entry name" value="TANGO2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17985">
        <property type="entry name" value="SER/THR-RICH PROTEIN T10 IN DGCR REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17985:SF8">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05742">
        <property type="entry name" value="TANGO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCF46405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC68344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="39463" checksum="061A9DF88DD857B3" modified="2016-11-02" version="1">MCIAFYTLSQPGYKLILASNRDEFLARPTEPAKWHNFSASPNANGKVDRDENEGWVLSGIDAGATNGGTWLGITKDLRIGLLTNNRLTPPIPPFKPSLNPPSRGLLLKEFLSPKPENAPQVHQYLKSHYKSSNEYEGFNLLLFSLRNPNPEIGYLTNRPEPHLSNLHIPLTINNHDDFSIKCFGISNSPMNKPWPKVENGQKQMEKNLKQWKLNNENEKQLINRMFDILSPNIPIKTENDSKLSIQIPLINLSSHLTNSPIDNKINKINEENPTVSIDTNTNTNVLEEDKLKMKSKWYGTRTSTIILIKDNGETIFVERDILILDQNGNPKKGNDERWFNFKGDIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HTQ4</accession>
    <name>A0A1B9HTQ4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Fe-S cluster assembly protein DRE2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_07504</name>
        <name evidence="13" type="ORF">I206_106605</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the anamorsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KI894016">
        <property type="protein sequence ID" value="OCF46651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007870.1">
        <property type="nucleotide sequence ID" value="XM_019159198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HTQ4"/>
    <dbReference type="STRING" id="1296096.A0A1B9HTQ4"/>
    <dbReference type="GeneID" id="30175873"/>
    <dbReference type="KEGG" id="kpin:30175873"/>
    <dbReference type="OrthoDB" id="311633at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03115">
        <property type="entry name" value="Anamorsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007785">
        <property type="entry name" value="Anamorsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046408">
        <property type="entry name" value="CIAPIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273:SF14">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05093">
        <property type="entry name" value="CIAPIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anamorsin C-terminal" evidence="11">
        <location>
            <begin position="201"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Fe-S binding site B" evidence="9">
        <location>
            <begin position="276"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 1" evidence="9">
        <location>
            <begin position="276"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 2" evidence="9">
        <location>
            <begin position="287"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCF46651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC72641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="312" mass="33849" checksum="74DECCDFA5493482" modified="2016-11-02" version="1">MTVMNGFATASSSTNTTMQVVVGSMERIQEYQSILTELKNRGGNVQGEMVDRILDNATTFPSSPLTIHLILPLPLPTTIISSIPPSTQLFIHLPTNHSENDLTSLHTLLASKSFTPLLPTPSSSIIAYTSPSTPSVPVPSSAPISLSSGSAKPLTLKRSGDKARKAALWALDSPLLEDGGKSLLTPEDKQRPECIFPENDGKKVKRRRACKDCTCGLKELEEKEEEQTNLTIKEAQKSFFLEGDDDIPEHLKNATVGIEGIWPTEKRAEAKKTSSCGSCYLGDAFRCSSCPYLGLPPFKPGEQVKLSIADDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HTR3</accession>
    <name>A0A1B9HTR3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_07503</name>
        <name evidence="3" type="ORF">I206_106606</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894016">
        <property type="protein sequence ID" value="OCF46650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007869.1">
        <property type="nucleotide sequence ID" value="XM_019159197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HTR3"/>
    <dbReference type="GeneID" id="30175872"/>
    <dbReference type="KEGG" id="kpin:30175872"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF46650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC72642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="261" mass="29120" checksum="DB7BDB5D43BD5E96" modified="2016-11-02" version="1">MPTSPHDECETIDCTQIAKQVTTATSYAPRWERQGSILDLPFFSPSTTFQSQKQEQPTLLPTPAPSPPVYTVPPFPLSESDFALAEGIDDELLRRLEKEVKAKKRADHRAVKRQKREEGQIATLRRISENSEGLQVFLVDDDEVKDDLGVEITRKHPNVEGKHEHKCSSELSSEIKDMVNIMETQDTFHSLSESSLALQYEESQQSSQASDSLPHCSIQSQSSSEDSYLPTPSPSPTKVSYSSNFQGVMIPDTKFGFGVCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HUR2</accession>
    <name>A0A1B9HUR2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">High-affinity iron permease CaFTR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_06772</name>
        <name evidence="10" type="ORF">I206_102135</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700117">
        <property type="protein sequence ID" value="OCF46998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC68212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008217.1">
        <property type="nucleotide sequence ID" value="XM_019158471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HUR2"/>
    <dbReference type="STRING" id="1296096.A0A1B9HUR2"/>
    <dbReference type="GeneID" id="30175141"/>
    <dbReference type="KEGG" id="kpin:30175141"/>
    <dbReference type="OrthoDB" id="4364at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004923">
        <property type="entry name" value="FTR1/Fip1/EfeU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632">
        <property type="entry name" value="IRON TRANSPORTER FTH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632:SF2">
        <property type="entry name" value="PLASMA MEMBRANE IRON PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03239">
        <property type="entry name" value="FTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0410">Iron transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="372"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCF46998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC68212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="414" mass="45549" checksum="EEC52B6184E3C730" modified="2016-11-02" version="1">MGHQYFNVPIFFIVFRETIEAAIIVSVLLSFVEQLMLTGKLSSSSTSIDDDNASPTDNSDRRRKLIKRMRIQIWAGTAVGFLLALAIGAAFIAVFYTKLNDLWAKTEQIWEGIFSIIAAIIIYVMGIAFLKMDKSRIKWRLKLAAAFDKSQAKMQASAEETEKDKREARSGKWALFILPFITVLREGLEAVVFVGGVSLNVEAVSIPIAVIVGIIAGLVVGYAIYRTGSTATLHWFLVGSTSFLFLIGAGLFSKGIGFFQYYRFAKGVGGDVAETGDGPGSYQVAGNVWHLTYGNPETGSPTTNGGWQIFNAIFGWNNTATIGTILGYVFYWILIMVTLIYLRWKEGRTTFKYPTTENGKIAWATKESAAAKRRNAGKGLERRVSDNSGSDDKHTKTEPETPGLSGVPHLNETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HUV4</accession>
    <name>A0A1B9HUV4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mannose-P-dolichol utilization defect 1 protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_06824</name>
        <name evidence="12" type="ORF">I206_102083</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
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        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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        </source>
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            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
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                <person name="Young S.K."/>
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                <person name="Gargeya S."/>
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                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
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                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
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<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
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                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF47246.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC67966.1"/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="528" mass="59989" checksum="F52E8C906820575F" modified="2016-11-02" version="1">MSKSHNRHFFYHKETNTTVWDKPSSNEKEKEEQDIRPASPPLAQTTSQSTQRRSNQDTDLSGKPLATGKVPPTGPSERKEHVRGVETKPHYDKYWAQRDVSYQAQTQAQHQERMAEKEKRRAREPSPIKTGQEYKRFRGDNDGNESRRQPELKPLQDYKPAQPSPRPSDTSSVTTDKPKDDPRTRPYNGAYVPPVVRHHNPHYTKPSPRSPTGSRGSATPSYQPNSGPKYQKDFSRPPPSADYRKDDYSRPPPSARHDSATYTSRGPPISRGEVDEAEIERAKIRDEARKAQEKLEFLKQAEARLEREMSEKRRPGPPTEKDNYSRSSRPSYDRPGPPSDIKRSYPPRERDYPPSQHHNPRYDKGSDSRYEGGRGGYQPEATRGGGYDNRSSGPPRGYDNRPPPRGGYDDRSYQSRPPPFRPNSPPPPSSRYADAPREGRRSPPPFGSRSGPRPDSPPRRGDRDLASRLGGGRGRSELAAEPMSAQAIDRERDRRSPPPSYRDRPRSGPGPSRPLAERMSFDDRRGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HVJ8</accession>
    <name>A0A1B9HVJ8_9TREE</name>
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        <submittedName>
            <fullName evidence="14">Ferro-O2-oxidoreductase</fullName>
        </submittedName>
    </protein>
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        <name evidence="14" type="ORF">I206_07076</name>
        <name evidence="15" type="ORF">I206_101834</name>
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        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
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        <property type="protein sequence ID" value="OCF47297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Chromosome 2"/>
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        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:reductive iron assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="CuRO_1_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13877">
        <property type="entry name" value="CuRO_2_Fet3p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CuRO_3_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FET5p Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Cu-oxidase-like_N"/>
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        <property type="entry name" value="Cu-oxidase_2nd"/>
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    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
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    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
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        <property type="entry name" value="Cu_oxidase_CS"/>
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        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
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    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
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        <property type="entry name" value="CuRO_2_Fet3-like"/>
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        <property type="entry name" value="IRON TRANSPORT MULTICOPPER OXIDASE FET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628140" evidence="10">
        <location>
            <begin position="21"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="576"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="13">
        <location>
            <begin position="29"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="11">
        <location>
            <begin position="160"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="12">
        <location>
            <begin position="389"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCF47297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WWC67916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="632" mass="70955" checksum="4CF56B57896805A6" modified="2016-11-02" version="1">MVAITTFFAVFPLIMRTAHAAISEHWWNISYATANPDGLYERRVIGVNGTWPPPPITVTQGDTIRIHAYNGLGDPAIGTALHSHGMMFNNSNWYDGAVGITQCSIPMSHTLDYEIDTSIQTGTYWFHGHYLGQYVDGLRSPLIIEPKNGTGRSDDLEWDEEFTLVVSDWYHRQHLDLLTNDFLTWHNPTGAEPVPDSALIYLVKDGQYYPSAEAITNGEGTNDNLSIPFEAGKKYKMRVINMSALAMFLIAIDQHDIQIIEVDGVEVEPYPIDALTISVAQRYSVIIQAKETSDKNYAMAVMQSEEMYDYLPDELVMNNTIQITYNPEAPPASEAVYDEISDLDDTVLVPLLKREMAPADIEFEIHANFDTYDDGTNRGNFNNVTFQEPKTPSMFTALTMGNNSFRSDVYGKMTNAIAYPHMANIQLTVYNWDAGPHPFHFHGHEFQIVQKSMDVTSDDPEDNPPLVEGQSNPMRRDTVTIPSTGKVVLRWRADNPGAWFFHCHVDWHLSSGLAVVFIEAPEKLQENHDVPQPLIDQCKYWGLPTSGNVVGLNSTTDFIGQPWGPFPMVIGWTPKAILSIVACIITALIGAFTVIWYGKDELGSKDIEEEIKQKLELKRNKKGLVKRITGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HVP3</accession>
    <name>A0A1B9HVP3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_06223</name>
        <name evidence="8" type="ORF">I206_101804</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008547.1">
        <property type="nucleotide sequence ID" value="XM_019157934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HVP3"/>
    <dbReference type="STRING" id="1296096.A0A1B9HVP3"/>
    <dbReference type="GeneID" id="30174592"/>
    <dbReference type="KEGG" id="kpin:30174592"/>
    <dbReference type="OrthoDB" id="5204190at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF13">
        <property type="entry name" value="MFS GENERAL SUBSTRATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="494"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="517"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="382"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="382"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCF47328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC67886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="553" mass="60499" checksum="5952F8D09F355A2D" modified="2016-11-02" version="1">MSAIKSYTEPSSSSASSSTRSTIKPDTEPNENTSLLLSKSDDAITKTKKEGGFFGPVPRVFFTSTLLSMTFAFTQTTLIYAFRVMTCEEYHKTHTWNGNGKDKCNIPYVEAKTARQIAIMSTVTVSAMIANLFLSGWSIKKFGVKATMFQQTFWAALRNLCQMYAIKTGAGTGMLIIQSTQLFNILGSAGGYQIASNVFVSMLVPAEERTKQFGVLAGMIMLGSSLGYTLGGLAYTYYGLLAPFQCAFYLLCFCTVFGALFLPYLPPDKKEESTNSEEKKKQSFLAPLKLFIPKLVETSDGRLKRDYNLLLLGAGAFVSVLATGYVHLALQLVGTDVFDFTPSESGMMLSGNLLIRAFFLSICFPWIITYGRRLISHRKDVPTGAASEEHPERPIEAEEPDDIGAPREDQARQPTDIQHGSTFDLYFLRWSIFVDGLLTGLTTLSNQGWHLYLAAGVLPFASATGAACKGVTLDFVEPHQRADALSAIALIEKVAQVSTISLFSNIFAVLSEQGKPTLVFLANGVTAMIAFILLLFVRMPKPKPDEGRIALSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HW40</accession>
    <name>A0A1B9HW40_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_06369</name>
        <name evidence="6" type="ORF">I206_101662</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008687.1">
        <property type="nucleotide sequence ID" value="XM_019158074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HW40"/>
    <dbReference type="STRING" id="1296096.A0A1B9HW40"/>
    <dbReference type="GeneID" id="30174738"/>
    <dbReference type="KEGG" id="kpin:30174738"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF20">
        <property type="entry name" value="PRO1A C6 ZINK-FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="48"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="77"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF47468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC67750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="809" mass="90541" checksum="5E584AAFEEC1D188" modified="2016-11-02" version="1">MSLHLDYAEISRQARKIVDANRARSIIDQVISDPESKQKVKYTRSTTGCLSCRSHKVKCDETVPACLRCVASQRKCEYPQPGESSNSNNNGKKRKSTSVSNSRTGGRRSTSVREEEGESKIEFNNSNNEGSKRFKEDYKKQSNQQRQQQDNNNNKNTNISPKSMLVDDGSKVDPSPTDNSRLGGPSPMDILNLTTTPDFSFLNDFIPFPHITPPSQPIPQQQGSSSQNIFNTSPTTIFTNDLTRPQQTGYGAIASTNNVITSNARNSVSDSVSNQYQNQAQAQALQNTLPHFDNFGKSLLLNRRLIKVNNNGNNDGNMVQDEEGRRSFTPQMQVIHPRLQMVDTFLQAFVHDEVLFEFGPSHRHRNLSNNTLTAGVIDVLTNAFPSPIARTLFHHYCNTASKILITMGNIGPNPLLTLCTPVKLLDTNSAASAAIRMSMLSTAIAHFIHETNSLLKQSNSSNLGLSYNLGLEGMGVGQWERMKLKMKEMSNKFKKASLSNITLAASSEKSPDQVDSILAACTLLCIRDVISADPTWRDNLEFALNLITKKGGPQVMLQGSEYTFTRRYLLENLATHDVFASFITGKEPSMLGNYDSWWFDSVETSQTRWEWESVERSFGISRAMVDLVARIAVLDSQKRRLGLSLKGGSDEMWDVGQHFERESHCLLLELDIWGNSLNALPQHVRVTCGDYIYKYMAVVFILADILEQPTSTPRIIKSIDHILELISEASAMRMSVMLIWPLLIAGVFSLPAKRQKVVELFAALSDDYCEDLEVAKELLDEQWRMVDSGQGKQPWDAIMKKLGKYVLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HW85</accession>
    <name>A0A1B9HW85_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP phosphoribosyltransferase</fullName>
            <ecNumber evidence="5">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">I206_06422</name>
        <name evidence="18" type="ORF">I206_101608</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="5"/>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008740.1">
        <property type="nucleotide sequence ID" value="XM_019158127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HW85"/>
    <dbReference type="STRING" id="1296096.A0A1B9HW85"/>
    <dbReference type="GeneID" id="30174791"/>
    <dbReference type="KEGG" id="kpin:30174791"/>
    <dbReference type="OrthoDB" id="2574at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.120:FF:000003">
        <property type="entry name" value="ATP phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000123">
        <property type="entry name" value="HIS1p ATP phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00079">
        <property type="entry name" value="HisG_Long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020621">
        <property type="entry name" value="ATP-PRT_HisG_long"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018198">
        <property type="entry name" value="ATP_PRibTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013115">
        <property type="entry name" value="HisG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00070">
        <property type="entry name" value="hisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03455">
        <property type="entry name" value="HisG_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403:SF8">
        <property type="entry name" value="ATP PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="ATP PHOSPHORIBOSYLTRANSFERASE ATP-PRTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08029">
        <property type="entry name" value="HisG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="GlnB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01316">
        <property type="entry name" value="ATP_P_PHORIBOSYLTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 17" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP phosphoribosyltransferase catalytic" evidence="15">
        <location>
            <begin position="95"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine biosynthesis HisG C-terminal" evidence="16">
        <location>
            <begin position="266"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OCF47521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="WWC67696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="343" mass="36260" checksum="D6C04A963A64F031" modified="2016-11-02" version="1">MSAQSTIPPTSSPSPAEPSSMGGRASKSSFGAESTMSLLVDSLKDRLLFAVPKKGRLMEKTLEILAGADIKYNRAHRLDVALVQNHPIALVFLPAADIPRFVALGSVALGITGQDVIAESTHADNITELLQLGFGKCSLQVQVPVTGPIQTVEGLSGGRIATSFEVLAAELFNGKSGIDSKTGKSTKVEYVGGSVEAACALGMADGIVDLVESGDTMRAAGLHAIHTLMKSEAVLITSKEPHQTLTPELKSLITLIKSRVAGVLAAKKYVYASYNIERKNLDKALTITPGRRAATVSPLETEGWVAVSSMVERKEMAKVMDELETTGAEDILIFALDNCRVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HW99</accession>
    <name>A0A1B9HW99_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit B</fullName>
            <shortName evidence="5">eIF3b</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 90 kDa subunit homolog</fullName>
            <shortName evidence="5">eIF3 p90</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Translation initiation factor eIF3, p90 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">PRT1</name>
        <name evidence="8" type="ORF">I206_06442</name>
        <name evidence="9" type="ORF">I206_101588</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="5">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 6">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the eIF-3 subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008760.1">
        <property type="nucleotide sequence ID" value="XM_019158147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HW99"/>
    <dbReference type="STRING" id="1296096.A0A1B9HW99"/>
    <dbReference type="GeneID" id="30174811"/>
    <dbReference type="KEGG" id="kpin:30174811"/>
    <dbReference type="OrthoDB" id="10250414at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03001">
        <property type="entry name" value="eIF3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011400">
        <property type="entry name" value="EIF3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 EIF3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036424">
        <property type="entry name" value="eIF3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="43"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR036424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF47541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC67676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="755" mass="86437" checksum="A6FAD5EC9A646D57" modified="2016-11-02" version="1">MSEFEKIEGLTEEEQLDFEAELQEGYADIEDKYAVDTQQGFENVLVVDNIPVIDEGKKQKLVDRLRQLFAKAGAPIEEDDISMPWDDKAATNKGFIFLTYPDAQQAENALRALDGASFGKSTLYVNRFGDIERYANLPVGEGELPTGWREKAFVEKDHLRSWLGDSAGRDQYLTFRDTDVAIWWNGRNGNAEPVKVDGKPLKNSKWGELYLQWSPLGTYLTSLHRVGVALWSGPKLDGPIGVNVLRFTHPGVRLIQYSPCENYLVTWSEDPLENFENHPNAALRETFGPEDEGNVFVVWDIKAQRVLRTFPPEKPVQGEDGPQQMPWPLFKWSPDDAYIAKVNVGTGISVYELPGMGLLDKKSIKIEGVQNFEWCPMSDKDFAARKAGKGKECSFVFWTPEAQNQPARVSIMSIPSRNILRAKNLFNVTDCKFYWQNQGDYLCVKVDRHARKAKSKKATFCNLELFRVREKDYPVEVIEFKDYVPQFAWEPQGNRFAIVSSNDPNYGQGIPGVVVKYNIDFYQLDQKKGDFIAIKHLDGKIANTLVWSPRGRHIALATIGSSQKFDVEFWDLDFVVDERRETSEPGANVTMLASGEHYGITDIAWDPSGRYLATSASAWRQTPEPGYCIWDFKGQQLVHQPQDRFKQFLWRNRPATLLSKDQIKKVRKELKEYSRTFDEEDAAEENRGSAEKLAQRQRDISEWNAWRSRNNKKLSERRSELGKEKKVPIVNHQDDEKVEEIVEELIDETEEVVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HWF5</accession>
    <name>A0A1B9HWF5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_06507</name>
        <name evidence="3" type="ORF">I206_101521</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008823.1">
        <property type="nucleotide sequence ID" value="XM_019158210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HWF5"/>
    <dbReference type="GeneID" id="30174876"/>
    <dbReference type="KEGG" id="kpin:30174876"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF47604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC67611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="287" mass="30425" checksum="8F37250EBAAEF165" modified="2016-11-02" version="1">MSSTNGRVLRNVEGNIQRRGVQTSNGNGSEYHGDNDGNVNHFPTNRAPWSRPAHEYLGNSSNPQHSHMSWTSAGSAGDLPQGGRGRINHFGDNTGGVGIYGGSNSGFRFETGFGDSGSPDTNQHTSDWVPPSTESGREANPPPTAGATAQPTELADATDSDPDVSVPDDNHWPTNSSSGSGPNATQHHQDSAAPDAYTSPSELVAKYFKPLDGQTAVQADTAQRHRFGSRPNAPESNGQPIPTAYGPAAEIGRYIFSPQTPGQTLERQSDDSPDDEWEKVSDESTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HWG4</accession>
    <name>A0A1B9HWG4_9TREE</name>
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        <recommendedName>
            <fullName evidence="8">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_06514</name>
        <name evidence="11" type="ORF">I206_101514</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="8"/>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008830.1">
        <property type="nucleotide sequence ID" value="XM_019158217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HWG4"/>
    <dbReference type="STRING" id="1296096.A0A1B9HWG4"/>
    <dbReference type="GeneID" id="30174883"/>
    <dbReference type="KEGG" id="kpin:30174883"/>
    <dbReference type="OrthoDB" id="4699125at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000005">
        <property type="entry name" value="Phospho-2-dehydro-3-deoxyheptonate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DAHP_synth_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009395">
        <property type="entry name" value="PRK12755.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE DAHP SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225:SF12">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE, TYROSINE-INHIBITED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001361">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP synthetase I/KDSA" evidence="9">
        <location>
            <begin position="54"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR001361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF47611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC67604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="389" mass="41936" checksum="3120232DFFAABE8E" modified="2016-11-02" version="1">MSHGTPSPDRNRPLDDRKVTGYDPLIPPALLRHDLPVPTVANKTISAARRTAASIVQGTDPLSRLLVIVGPCSIHDVDQAKEYASRLRKGVQEGRWPGLEVVMRVYFEKPRTTVGWKGLINDPDINNSFSINKGLRIARQLLCDINEMGMPVGCELLDTISPQFIADLITWGAIGARTTESQLHRELASGASFPIGFKNGTDGSVGVAIDAMQSASHPHNFMGINSQGMASIVKTSGNADCHVILRGGTHGPNYASEHVQKALTTMRTKTPDNFASIMVDCSHGNSSKNHLNQPKVAADVAAQIAAGEEGITGIMFESNLKGGKQSSDKPRDQLEYGVSITDACVDWEMSVDMLDVLNKASLTRRSILDAKHANGNGELPAVKKLKTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HX48</accession>
    <name>A0A1B9HX48_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar protein sorting-associated protein IST1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_05704</name>
        <name evidence="4" type="ORF">I206_107378</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IST1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894014">
        <property type="protein sequence ID" value="OCF47844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="1296096.A0A1B9HX48"/>
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        <property type="component" value="Chromosome 11"/>
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        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Vacuolar protein sorting-associated protein IST1"/>
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    </dbReference>
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        <property type="entry name" value="Ist1"/>
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        <property type="entry name" value="IST1-like"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="IST1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="183"/>
            <end position="257"/>
        </location>
    </feature>
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        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF47844.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC73411.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="30955" checksum="5575569CBC481D34" modified="2016-11-02" version="1">MVQWNGPRAKVQIKLSIQRLRTLQEKKLALAKSSRREIADLLNKNRIETARLRVETLVQDDIYIELLEIIELYSETLQARFNLLDASTGEEPEPSIADAVCAIVYAAPRTEMKELQLLRELLMHKFGRNFSLSLTQTPPPPSVPSRITSKLKVFVPSKELVDAYLLEIARGYGVDWAPELTEEEEGIEPLKRDLPDDDQNEANNKDESAGSDDDEGDGDKIEKLDKEKQKEKDKSPKKNSPEKKSSPLPPVPKKLSAEEELAQRFERLKNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HXX3</accession>
    <name>A0A1B9HXX3_9TREE</name>
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        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_05969</name>
        <name evidence="4" type="ORF">I206_107634</name>
    </gene>
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        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894014">
        <property type="protein sequence ID" value="OCF48101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009320.1">
        <property type="nucleotide sequence ID" value="XM_019157680.1"/>
    </dbReference>
    <dbReference type="STRING" id="1296096.A0A1B9HXX3"/>
    <dbReference type="GeneID" id="30174338"/>
    <dbReference type="KEGG" id="kpin:30174338"/>
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    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
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        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36812:SF9">
        <property type="entry name" value="MYB-LIKE PROTEIN X ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36812">
        <property type="entry name" value="NEUROFILAMENT TRIPLET M PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="668"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="636"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="853"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1029"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1161"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1244"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
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        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
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        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
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        <location>
            <begin position="645"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="863"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1029"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1049"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1172"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1244"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1270"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1285"/>
            <end position="1296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF48101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC73662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1319" mass="148228" checksum="2A671B6E048777A2" modified="2016-11-02" version="1">MTSTPDAGPSTNLSIHPSRLAKFHQITETDFQTEYTSGNPSTANNVKGSTTLDSGANSVPLRPKIKKRRVLVWTLPLKPLSKAASAEKKAKDKQKAKFYEGSFRSEAEREKEQQRKTAKARRASIKRAEKIRKERQKLKDKADKDEARRAYANEVDDRDSNNEHAESSATGASRNSDYILNIGHKKRQKGDKDKKKGKDKDKKQSKKKDKHKRKERHMDRDRNKSISNIPRELCPLELQALDVARKMNQTSVRSTPTETNAGDSTDQQSPSVTTRNTPTIPLTNEVEEEERIEYGPRLGILTNDMMNGPTGDNSTVYADSAQQPEAGPSRRPVYYVQYPVGGESFDTDGDGIFMKPEVEEQIAVWVDIALPGRMTLLKKIEAEGGQPSSDHADEDTQLIILHPASTYVFDMYCHPDWLRPRDRARYAPKRRKYGNRENSWQKKVLLKAPWVDKCLEAGRFLGQEDDWGGCRAGGPPVGTLMSTDPTLALPEDLNGQGDGSDHMFEGSNGVVENTEAQDTAQQSPLKDMDNRGDDRAVDADVIMEDVLSEVPMADSSIPSPPPTEVIENIAPQNNPDSEDDMEIMPTPVTGDRPNFSHVSKDKLVPKKAFSQLADTPAHISSDDYADSDATEIAPWTTTERPKQKSPPNLSSAAPGTATEGSKQTELLDPKTMFSGLKFWLDTTYPDRIPLIKRIKAASGDLVTSYSESTHVLINNYKEQQWRSIVQGLSKEGIWSLNIRWIHDCLDQGRKLHEFDFAVPYGVPLRDKEDEKKDEKTAVPYKFDDQDDHHLSNEELIAIFEREQKMIVKGGTLRALGAFLASKYGRYNENYWVKLHRAWSKKADRFEYLKKDAKDSMVKPGPATQSSPTPSQSSSQKTKSSTAVIPHEQLVEILTAEVPHQGSRNNTEFGIYLNQKYPVHPAITWSAYLSKFKSRKGQFAKLKTKQPARIARLDVSLPTSLSKVPLDKKLYSDEELVQIFSSPELNQAGSKSFNSLGKDLAAKYGVYHVTTWGILYSEWIRKSGRFKPTANNTSSLTQTDSTPTNKREPSTSVSTRPSISSPSKSKSISLAEYDDEEGGSLTASEKAVIFKEREEEFTQRKLNQVEIGLLLKTEVGIYARSHWRREWTAWWKRQGPYANIMECLQSTVAAKAYADQTMPIRGSRHKAKVESPAQDQRSPTVQSSGRSVVTRPYTMEEEKNMARYIAGYSKNTKMPQTWVKFAAMYPTRTASAYCKHYSTDQFRIDRYKPHDQSSNMKEDDTTPGTADNDLINHSQPSGSQSQPVEIDSDDDDDDEDNSVIMVNDNNNDKDYADVITIDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HY49</accession>
    <name>A0A1B9HY49_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Inactive metallocarboxypeptidase ECM14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Inactive metallocarboxypeptidase ecm14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">I206_06073</name>
        <name evidence="21" type="ORF">I206_107739</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="21" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Inactive carboxypeptidase that may play a role in cell wall organization and biogenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894014">
        <property type="protein sequence ID" value="OCF48205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC73767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009424.1">
        <property type="nucleotide sequence ID" value="XM_019157784.1"/>
    </dbReference>
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    <dbReference type="STRING" id="1296096.A0A1B9HY49"/>
    <dbReference type="GeneID" id="30174442"/>
    <dbReference type="KEGG" id="kpin:30174442"/>
    <dbReference type="OrthoDB" id="3626597at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Carboxypeptidase B2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF147">
        <property type="entry name" value="INACTIVE METALLOCARBOXYPEPTIDASE ECM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 18" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628250" description="Inactive metallocarboxypeptidase ECM14" evidence="18">
        <location>
            <begin position="20"/>
            <end position="545"/>
        </location>
    </feature>
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            <begin position="180"/>
            <end position="537"/>
        </location>
    </feature>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
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    <feature type="compositionally biased region" description="Basic residues" evidence="17">
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            <end position="155"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
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            <end position="268"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="16">
        <location>
            <position position="503"/>
        </location>
    </feature>
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    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022645"/>
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            <dbReference type="ARBA" id="ARBA00022670"/>
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        </source>
    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HY74</accession>
    <name>A0A1B9HY74_9TREE</name>
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    </protein>
    <gene>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894014">
        <property type="protein sequence ID" value="OCF48222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC73785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="kpin:30174459"/>
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    <proteinExistence type="predicted"/>
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        <location>
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            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF48222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC73785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="473" mass="53028" checksum="138FB0D32731B2C4" modified="2016-11-02" version="1">MDDSSDQSRRGQKRRLVNPGMGTSHPGSLDPTDSASIPYNAPPYNWPSYPGYAESGDPSGNRSEQTMYGRPPGTQIHNYSFGDQRIQHEDFSQSAPQTQFTNTLSNARVAGDLHFNYTTEPSASLVTYGQADIDRMWATLTEGIKGQHTGPASNYHDTVLDPFGQQQKPDFTPDLGANPLDAQFVSQQIPNLAHDLEIDPSGITDPAYNPSWSIYPALQAEGSAIAHQHGILEENKPSRDRRETIDYRPMTNKKIKDDFHILITKIMSRAVDPQLPHKSRFDIPENVIESLVADPATQQSQLSEGSESFYNLSPGQNSDIQTTQNNLYRLGKNKDETERMERWLEVFKQGNLVPDAYHIELNLSLSYKKKSFSMKDTTPVTVDHFDLMAKRALAEQDHKSVEAITRTKELWISLNDSSKHTSRVTTDASGFSLAQMQKAFDHSLNDESAAVEAPKAPFNLQEDFDQFLGRDYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HYM4</accession>
    <name>A0A1B9HYM4_9TREE</name>
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        <recommendedName>
            <fullName evidence="6">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_05166</name>
        <name evidence="4" type="ORF">I206_107290</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF48389.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC73323.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="459" mass="51281" checksum="600124C01DC7D12C" modified="2016-11-02" version="1">MSNRFNSKWQFLDYNQTQVVPYPPIFHLLSVILAFLAFAIIALWAAATVGYEPSTIFDTDINRTDDKHWFTTFIPRKIIESEKGKLCESAMFPTGSSLMTNAQFPSYTYTIIRYNRDPLYRLAVAEYRGSNLSVCAIDTLKITVKMVSGVVGIAAEVQCPEPWPAQLYTSINLDPGEIWAKTNLQDLALDLLSRLKVIFDSGQYTNNTTKGKWTMLNLILRDMTLNALEEDPNHRLQTVPPLTLNAMRLSNAEDSTWNGTSSASGAYYGRPPEIYNDFVIPLTNFIQVFISSIYSDLGIREGNIYANLTTLNQLINAKDNVANTSILGPKDLINTKELLSNIPINPYSSYSDLSIIRNNASVATAYLCHVTKLKSPADWIDSVAGLTLSIWGGLWTTYMLVVSYLSSRKAERMTDQTSISNDQGQMDKRTAFQSTSKSDTIDAVPLLLLRTEIPHPNSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HYN6</accession>
    <name>A0A1B9HYN6_9TREE</name>
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        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
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        <name evidence="6" type="ORF">I206_05164</name>
        <name evidence="7" type="ORF">I206_107292</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
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        </lineage>
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    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A1B9HYN6"/>
    <dbReference type="STRING" id="1296096.A0A1B9HYN6"/>
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    <dbReference type="KEGG" id="kpin:30173533"/>
    <dbReference type="OrthoDB" id="338650at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000824">
        <property type="term" value="F:inositol-1,4,5,6-tetrakisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF108">
        <property type="entry name" value="KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="212"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCF48387.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC73325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
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    </evidence>
    <sequence length="417" mass="46042" checksum="FE1C075FEE0F700F" modified="2016-11-02" version="1">MSSSLTIGESTPLANQVAGHDGVMSDASGSLVIKPALPREIAFYQTLNSSSREDPIRKLKPFVPKFYGTLRLEGQLSSEGDIKGLPGKEEIPESVVIQNLSYAFTHPNIIDVKLGKVLYGPDASEEKKYRMDKQARDTTTHETGIRLTGFTTWHEPTQSYIVTPKSFGKTISVSQLPEGMKRFFPLPNDVVPSLVSASPTKSQSELEIIPEKTGVSLESGIPPTPITASNAPSSESASSENKPQEYTNHTIRPDCMIKVLDLILEEIDKLFSVLSELEIRFVGASLLIVYEGDSSKLPKSLEKLEKKKALNLLKANKINEQRSAFSDDGSIYSSSNDSDFEDDFENEEGDDEILNEDEEENKIKLECSPIKLKLIDFAHTWLTPEEGPDQGVLLGLQTLKSLIEGRKDQIESAQKHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HYP1</accession>
    <name>A0A1B9HYP1_9TREE</name>
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            <fullName evidence="3">Uncharacterized protein</fullName>
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        <name evidence="4" type="ORF">I206_107283</name>
    </gene>
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        <name type="scientific">Kwoniella pini CBS 10737</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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            <taxon>Cryptococcaceae</taxon>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
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    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="OCF48395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HYP1"/>
    <dbReference type="STRING" id="1296096.A0A1B9HYP1"/>
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    <dbReference type="KEGG" id="kpin:30173541"/>
    <dbReference type="OrthoDB" id="10255630at2759"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="620"/>
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        </location>
    </feature>
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        <location>
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        </location>
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        <location>
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        </location>
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        </location>
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            <begin position="1"/>
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        </location>
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            <begin position="136"/>
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        </location>
    </feature>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF48395.1"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="WWC73316.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
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</entry>
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    <name>A0A1B9HZG0_9TREE</name>
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        <lineage>
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    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC73035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009896.1">
        <property type="nucleotide sequence ID" value="XM_019157178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HZG0"/>
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    <dbReference type="KEGG" id="kpin:30173826"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="OCF48677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC73035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="36369" checksum="A9EB90321B96ABB9" modified="2016-11-02" version="1">MQEGMVSDRAALRALEFDEKAFVKITPNFQMVKFSEKSNHIQSSHSQGDYRMSTHSGMNHPILKNDESRISINWDQITSLLEWQSSIKRNCRFVNDEEDLFKIIFCSVDEQIHAGCTWDVFRADDPDDDTSFWDGDEAYHRDDALKQIINEDYMLRQHLVKLQGLVVPRYYGMFVWHEEHDNKQENWIIATIMEDVGDPISEVMSRYSLPVKRQILDCFKHLHNIPHVVHQHTKYNHILERDNDDKRNIQVGKFFLIDFQHAVCLADWQYQEGQKELDREDKIMMWRLALRTDPTTGLIVDKRVRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HZM0</accession>
    <name>A0A1B9HZM0_9TREE</name>
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        <recommendedName>
            <fullName evidence="5">ELMO domain-containing protein</fullName>
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        <name evidence="7" type="ORF">I206_106939</name>
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        <lineage>
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    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.</text>
    </comment>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC72975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009956.1">
        <property type="nucleotide sequence ID" value="XM_019157238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HZM0"/>
    <dbReference type="STRING" id="1296096.A0A1B9HZM0"/>
    <dbReference type="GeneID" id="30173887"/>
    <dbReference type="KEGG" id="kpin:30173887"/>
    <dbReference type="OrthoDB" id="28413at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048870">
        <property type="term" value="P:cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024574">
        <property type="entry name" value="ELMO_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006816">
        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050868">
        <property type="entry name" value="ELMO_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771:SF56">
        <property type="entry name" value="CED-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771">
        <property type="entry name" value="ENGULFMENT AND CELL MOTILITY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11841">
        <property type="entry name" value="ELMO_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04727">
        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16457">
        <property type="entry name" value="PH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51335">
        <property type="entry name" value="ELMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="2" id="KW-0581">Phagocytosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0729">SH3-binding</keyword>
    <feature type="domain" description="ELMO" evidence="5">
        <location>
            <begin position="393"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCF48737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC72975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="809" mass="90979" checksum="BB1AA040F256759E" modified="2016-11-02" version="1">MSGQTSAPTPITRRGAIPTNVVTYKGRRIPARIDPEARVAYIVEIMSTSFATKEHHITLCLRDESDTLLTQNNLPSKVYNHDVLKLVPSAATEALVVITSLRSSARRGSLADSNLDLPTSSDGIPLKLALFNLQKYIKEEDFAVEFMLKGGMKMLVRLLERHEGGLGGNSLAYALQGIRGILEFESGWGELSDQFIDRMLNLVITASQPNVLKPATAIIRKLVISSPQLNAKDNNLAGLKMPVTPYGQTKKDRKGKSKEVTQVNQYGFDRIYNRIKYVVGDDDGTDHRGISGVELFFKVVVKRLEGTGDLELVAQSLGLINSCLRSGHQENSKQYPELVDLLERLSIRRYVSRLMPTSSNNVVEPQILTFQARYGVILQNTRLRPVRPGSTPVQEKMLRELWEYGRLGQPEQPSPGQMRKTGMARTAAGWKRIGLCQDGEEEAGFLMELEMFRDVGELGLESLHYFATHEDNFYNLIMEQQAKPAERRCPIGKASSECVKILCEHYKISQAGHHSPANFQLFLLNFSKLHQLVLRFFMRMWQESASQTPDFPKVSFLVRSQIRLSLSDEGNKTWLNLEQDFLDTEYRTIRDRQMELLEKEDGMMSRYGVRELRDKLGREGYEVLSEQRIGCMLQGGWFNSALLNVPGISSSVRPNAQKPLRFMRLSLNRKVIAWDQFSHRIENPSFEFLRERLDIASISSVRLQTGCAVNSRSPNLVSKLSFSIMGEGETSLLDLDAIHAAQMAEWTDGIRVLRGEGGMSSKESADYIHILAELALKVRLLDITGDGVEIPEKITFGAAPQSVDFVFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HZR9</accession>
    <name>A0A1B9HZR9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Decapping nuclease</fullName>
            <ecNumber evidence="6">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_05536</name>
        <name evidence="9" type="ORF">I206_106919</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside-ribonucleotide in mRNA + H2O = a (N(7)-methyl 5'-triphosphoguanosine)-nucleoside + a 5'-end phospho-ribonucleoside in mRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66928"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17313"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:172876"/>
            <dbReference type="ChEBI" id="CHEBI:172877"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:66929"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60880"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:60881"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78683"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78684"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DXO/Dom3Z family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="6"/>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC72955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009974.1">
        <property type="nucleotide sequence ID" value="XM_019157256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HZR9"/>
    <dbReference type="STRING" id="1296096.A0A1B9HZR9"/>
    <dbReference type="GeneID" id="30173905"/>
    <dbReference type="KEGG" id="kpin:30173905"/>
    <dbReference type="OrthoDB" id="5853397at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034353">
        <property type="term" value="F:mRNA 5'-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110155">
        <property type="term" value="P:NAD-cap decapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013961">
        <property type="entry name" value="RAI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039039">
        <property type="entry name" value="RAI1-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395:SF9">
        <property type="entry name" value="DECAPPING AND EXORIBONUCLEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395">
        <property type="entry name" value="DOM-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08652">
        <property type="entry name" value="RAI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RAI1-like" evidence="7">
        <location>
            <begin position="25"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF48755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC72955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="390" mass="44280" checksum="1D23CAA6E1677416" modified="2016-11-02" version="1">MSSFKTSHFLPLPPLSLRTPPPSYRKPTIISTYSHLPDRSIQHDDSSMTYYRAAPIGADLNYGFDRRIERDEDLDEHLDGVCDALRHVEEKGGKGERKGGIITWRGMITRIMTAPYEDREGWEMTAIALDGSVYVELHDPPDVRANRRKQQSTWAWQTYMGYSFESFSTVPAEAGTGDKDFPEGWGGDVNTNVQWCNVVRSAIGDIPLCLGGEVDCVRAEPGTSHPGLESCVELKTNKVIENEKQEFIFHKKLLKHWAQSWLLGIPEVQVGFRDDHGILLNQRRFETEKIPRFIASIPSAHPPWTPNPCLHFLHAVLNLVITNVLPTDPCSRYTPGSINPEDDLPPATIWRFSFIPRRGCELYKVGEMGVDQDGRWGGMLKEDYVRWRMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HZW8</accession>
    <name>A0A1B9HZW8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetylglucosamine diphosphorylase</fullName>
            <ecNumber evidence="3">2.7.7.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_05591</name>
        <name evidence="9" type="ORF">I206_106863</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate + UTP + H(+) = UDP-N-acetyl-alpha-D-glucosamine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="3"/>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC72899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010029.1">
        <property type="nucleotide sequence ID" value="XM_019157311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HZW8"/>
    <dbReference type="STRING" id="1296096.A0A1B9HZW8"/>
    <dbReference type="GeneID" id="30173960"/>
    <dbReference type="KEGG" id="kpin:30173960"/>
    <dbReference type="OrthoDB" id="532420at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04193">
        <property type="entry name" value="UDPGlcNAc_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000075">
        <property type="entry name" value="Probable UDP-N-acetylglucosamine pyrophosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039741">
        <property type="entry name" value="UDP-sugar_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952:SF2">
        <property type="entry name" value="LD24639P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952">
        <property type="entry name" value="UDP- GLUCOSE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF48810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC72899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="520" mass="57892" checksum="2681D671B5FC741F" modified="2016-11-02" version="1">MSSLPIQINGANGNNSPSKKDSLLERVKATYEEAGQSHVFTFFDKLSTSEQNNLLKQLDEIDIHRVNRIYKNAILADGSQTLPNDHEEISPLPEEACATIINNPIEESKWRKLGLEAISKNQVAVLLLAGGQGTRLGSSLPKGMYDINLPSKKSLFEYQGERIGKLAKIASEKAGKKEGEVRIKWYVMTSGPTRGETEKYFKEKDFFGLNKDDVIFFEQGVLPALSEDGKLLLSTPSSLSVAPDGNGGLYAALRRPLSSNDSRTVLSDMKSNGIEYIHAYCVDNCLVKVADPVFIGYCLSKQSQAGAKVVKKTIPNESVGILALKGKTFTVIEYSELSKEKSELKKPNNENGGEGELLFKAANIANHFYNRNFLEKIELIENKMSYHIARKKIQTINLKTGEIFKPNEINGMKLELFIFDVFPFINDLAVFEVSRQEEFSPLKNSPGSKADCPETSRKDLLAQQKRWLLFNGAIFDNENIEIEVTPNVSYSGEGLDWVKGKKFIKSGVLSKKEDLEGLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I035</accession>
    <name>A0A1B9I035_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_05655</name>
        <name evidence="2" type="ORF">I206_106797</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
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            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 10737</strain>
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    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">CBS 10737</strain>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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            <strain evidence="4">CBS 10737</strain>
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    </evidence>
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                <person name="Heitman J."/>
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                <person name="Young S.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
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                <person name="Imamovic A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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                <person name="David-Palma M."/>
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                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
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                <person name="Cuomo C.A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="6">CBS 10737</strain>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF49079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC71984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="355" mass="40012" checksum="16167795B946C93B" modified="2016-11-02" version="1">MSGQAFEPKNMLYRNLGATGLRVPVFSYGGWLTVGYEQKGDIVKELMQTAFDAGINMFDNAEAYAGGESELQMGRVIKELGWKRSDIIVTTKIFFGIGRKERHNTRGLSRKHIVEGLNDSLERLQLDYVDIVFAHRPDVTTPMEETVRAFNHVIDTGKAFYWGTSEWSAMQIQQAHEIARRLNMVGPAAEQPHYSMFHRERFEQEYEPLWRYENYGSTIWSPLDSGLLTGKYNNGIPEGSRYHSNLNGAMDDNVKHLTSPEGQAKIEKVKKLTAVAERLGGSMTSLALAWTLKHKGVSTCILGATKPDQIKENVKALDIYPKLTPEVLEEIEKILDNKPALPTAYGRRSDEGDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I0Y1</accession>
    <name>A0A1B9I0Y1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_04862</name>
        <name evidence="9" type="ORF">I206_106039</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL43 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010393.1">
        <property type="nucleotide sequence ID" value="XM_019156591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I0Y1"/>
    <dbReference type="STRING" id="1296096.A0A1B9I0Y1"/>
    <dbReference type="GeneID" id="30173231"/>
    <dbReference type="KEGG" id="kpin:30173231"/>
    <dbReference type="OrthoDB" id="88at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039927">
        <property type="entry name" value="Ribosomal_mL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="7">
        <location>
            <begin position="36"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF49174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC72079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="150" mass="16777" checksum="DA6D4F969E4BE2A6" modified="2016-11-02" version="1">MPRLVPSSSSIPKTYPVPGYNHFLTPLRKLIFDYDAESPSQHGIRSFIRKPLINLARENPDVEFVVRRLKRGKAAVLRGHYVNGRDKVICVNKLEMDGVTNKVKLLLNSSGAKIKPLKNLTLEAAPASESARGVWSALHDQMKDGQGYRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I138</accession>
    <name>A0A1B9I138_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Catalase core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_04866</name>
        <name evidence="2" type="ORF">I206_106043</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010397.1">
        <property type="nucleotide sequence ID" value="XM_019156595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I138"/>
    <dbReference type="STRING" id="1296096.A0A1B9I138"/>
    <dbReference type="GeneID" id="30173235"/>
    <dbReference type="KEGG" id="kpin:30173235"/>
    <dbReference type="OrthoDB" id="3358373at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36195:SF4">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01990)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36195">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01990)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCF49178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC72083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="43532" checksum="A698E9B3F82C3FA7" modified="2016-11-02" version="1">MQAISDTLQSATELVVGPTIVAGPEEWLKADETEQREEDEDAKILRVGELVHDMQSHNFDAHQHKFRGTHVKSLGFVKGSIAINSDLPSYLQHGLFAEVGKKYDCIGRYANEPSFILPDNTSAPRGFSLKIFDVNGERLSPAPNGSTNQGTQDFLFNNAPIVELTNLNTTIEIFELRTKYFDNPTQLNLELAKRSDRLKQFAPFMLPNKYVIGSTFYSQSAFKFGPYACKFSLLPISQFQEEFKGKTIPKDSNKTFHRDHIREYYSKNPTEYKLRAQFSSDLNKQPIEDASIEWKESYSPWYDLAIIKFDSQETFSDERRIWWEDHIGLSPWDGLLDHRPLGSINRLRHKAYEMSRAYREKGNQTKVYLPLKVEDIPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I1E4</accession>
    <name>A0A1B9I1E4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BUB protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_05055</name>
        <name evidence="9" type="ORF">I206_106229</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010581.1">
        <property type="nucleotide sequence ID" value="XM_019156779.1"/>
    </dbReference>
    <dbReference type="STRING" id="1296096.A0A1B9I1E4"/>
    <dbReference type="GeneID" id="30173424"/>
    <dbReference type="KEGG" id="kpin:30173424"/>
    <dbReference type="OrthoDB" id="248495at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13981">
        <property type="entry name" value="STKc_Bub1_BubR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.430:FF:000003">
        <property type="entry name" value="Checkpoint serine/threonine-protein kinase BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015661">
        <property type="entry name" value="Bub1/Mad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013212">
        <property type="entry name" value="Mad3/Bub1_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030:SF4">
        <property type="entry name" value="BUB1 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030">
        <property type="entry name" value="MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08311">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00777">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51489">
        <property type="entry name" value="BUB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0137">Centromere</keyword>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BUB1 N-terminal" evidence="7">
        <location>
            <begin position="70"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="981"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="272"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="373"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="509"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="577"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="607"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="778"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1006"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="383"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="519"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="609"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="634"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="657"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="680"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="787"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1008"/>
            <end position="1023"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF49362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC72267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1319" mass="146418" checksum="9C817C9BEBF3F4BA" modified="2016-11-02" version="1">MDSLFSPAQRPASPSSGPVTDFALIESQKENIRPLATGRSAATLSNVFKEPTAADKVVQDGHERFRKDIEEAERRDKEGEDMVDGIQDVLDVYNKYILFVVQHHPSSDTHLLPLLETSTRRFVNDARYTQDVRYLKLWVMYARQIERREEIWSFLESRDIGTRHSVFYEEWAGALEGLGRRKKADEIYRLGTARKALPLDRLKNRHKQFLERIMAPPSGIVPEDDPSSSSAPLRTPGRSVLGQVATASTSVAGATQLAPSLRVASKGNGSKMEIFSDGSGKNEDSAPGEWADFGTRDARRKENTVEATQWKGETLPQSAARTRVAPRTPKVEVFKDVTENEGIRVADEVFVRQRQPPTEAELLKSDPLRHYDTSNLSTAIPSLPAPPSARKPPKPNGKPTGGFVMSPWECPKDGFEVRSAAGKLERRMFDWNAVFKNDDEWSFEEIRARQRGLLGRDWKGEVKEWERTWHLPGSSTPKAEVKKVKPPSPTVNTKLAELEVMRMFDQTIHGGKIRGAGDSDTDESSDEDEEDEPIQCAPTPLPSRQGPVTMLAPTPGGAVPPTPTPAGQVQSRLFSPADENGQSYIPSQPFVFSDENTPSVKPGLAVFSDENSVPPSANKTGKFNIFSETPAKTPLNNKTPLATTSSSKPKAFGVFSDEQQGNAQDAVQATPSAPPKRKPLSQNLFATPALTRQSSYGRGTTEIIQEVPEGEEDEGAADLVHQVQEEVGQIELNDGHEDDEDNERPRGGMRRFQINAMTPITERTCEYTNMTNLRSSVGGNARPFSVAEDEDENVSQDNEEFPSNVSEPALVASDSKSQILPPISDVTTDHDHSLLSEEDLPSGDLDGKFQLPEGFTIHRNQNDIHTMVLTDGETMHTAREGSVEPTTEHFVTASHGHGAHFSIPNPCEPYSEEASTAVMKSIQPPITSLNGFMDCRESTSGKWGVLQKYAKNKGRRGSTNSRASVAPSDDVVNIELEGKGFEIQEKIGEGGFGLVFSAVDIAQRQLQDDADSDDEDDDQETDEPQDKSILAIKVENPSSIWEYVILSRIYQRINPTFLPSIIQMRSIYAFKDESFLLMDYSSQGTLLDIVNKATSIGIAPSTQGGTSTLDELLTIFFMIELLKIVENLHENDIIHGDLKIDNCLIRLDEIPNSKWSPSYSQTGAEGWNKKGIKLIDFGKSIDLTLYPAGKNQKFINGDWKADEKDCIQMQEGTSWNYHTDYFGLASIAYTMLFGKHINVEKNDGIWGIDQGLKRYWQQDLWHELFNTLLNPGEELPITPRLVGIRVKFESWLEDNCQKGGKSLKSMLKKIELAAITGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I250</accession>
    <name>A0A1B9I250_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Splicing factor Cactin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_04152</name>
        <name evidence="8" type="ORF">I206_104272</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CACTIN family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010849.1">
        <property type="nucleotide sequence ID" value="XM_019155891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I250"/>
    <dbReference type="STRING" id="1296096.A0A1B9I250"/>
    <dbReference type="GeneID" id="30172521"/>
    <dbReference type="KEGG" id="kpin:30172521"/>
    <dbReference type="OrthoDB" id="265955at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019134">
        <property type="entry name" value="Cactin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018816">
        <property type="entry name" value="Cactin_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737">
        <property type="entry name" value="POLYGLUTAMINE BINDING PROTEIN 1/MARVEL MEMBRANE-ASSOCIATING DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737:SF4">
        <property type="entry name" value="SPLICING FACTOR CACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10312">
        <property type="entry name" value="Cactin_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09732">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Splicing factor cactin central" evidence="6">
        <location>
            <begin position="234"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Splicing factor Cactin C-terminal" evidence="5">
        <location>
            <begin position="637"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="608"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="194"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="87"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="615"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF09732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCF49630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC70322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I2I8</accession>
    <name>A0A1B9I2I8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alternative cyclin Pcl12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_04277</name>
        <name evidence="4" type="ORF">I206_104148</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010972.1">
        <property type="nucleotide sequence ID" value="XM_019156014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I2I8"/>
    <dbReference type="STRING" id="1296096.A0A1B9I2I8"/>
    <dbReference type="GeneID" id="30172646"/>
    <dbReference type="KEGG" id="kpin:30172646"/>
    <dbReference type="OrthoDB" id="244495at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF108">
        <property type="entry name" value="PROTEIN CNPPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="2">
        <location>
            <begin position="75"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF49753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC70198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="349" mass="37657" checksum="7A5C24F85E23D347" modified="2016-11-02" version="1">MSSSSSASIPAYRPSTSTPPSGKRKVTKPAASRSSQDPFYGHEETAVMSARFITSLFQCPNIPASTAPGAPTPTLAHFVAYALHRTRLPSVVTFAALMLLSRLKQRYPAARGSSGHRLFISAFMIASKVICDDTYSNQSWSIVAQKMFALKEVNQMEREMCGYLEWNLNVAGDEIVDFEAKIRSEHGPRAVARASTASSSSSSAGSVIVPIPVVSASRSYPTPETTPDPQPSSRPIRAVPSPYKARATYQPQQSAFPSPPISPVSHHSSPHPPHFTSSASSSLQSSPASDDCKTPSPVTLTGQHHHHHSKSSTRLPAKGFDMTRAFESRSRSHAVNMHLSNEPIHVGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I2K7</accession>
    <name>A0A1B9I2K7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit L</fullName>
            <shortName evidence="4">eIF3l</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_04303</name>
        <name evidence="8" type="ORF">I206_104121</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit L family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010996.1">
        <property type="nucleotide sequence ID" value="XM_019156038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I2K7"/>
    <dbReference type="STRING" id="1296096.A0A1B9I2K7"/>
    <dbReference type="GeneID" id="30172672"/>
    <dbReference type="KEGG" id="kpin:30172672"/>
    <dbReference type="OrthoDB" id="15082at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03011">
        <property type="entry name" value="eIF3l"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019382">
        <property type="entry name" value="eIF3l"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10255">
        <property type="entry name" value="Paf67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="335"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="577"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCF49777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC70173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="612" mass="69596" checksum="89773CFDA20A3DEE" modified="2016-11-02" version="1">MADPTAFYEPAEDELLSSLAVPVQSYNPDSEADEYRRLQELEQHAYAQQQLMVAEQEQEQLQALEQVPEDVKRFLVLFHQAILENDLPTITNMYESGWNKLTQAHYSQNEWPEAELISPLVGNDQVFLTLYRELYFRHVYAKLQPTIDDRFQSYENICELFNYLLNSEGPVPLDLPIQWLWDMLDEFVYQFSSFASWRANPKNKNEEELEALAEAQHIWSCYSVLNVLYSLVQKSQINEQLKAEKEGKSPEEVAEIAGDYGSKPLYRNLGYFSLICLLRVHVLLGDPTLALQTMEHVDLSGGAFLTRITACHVTTYYHVGCAYMALGRWPDAIKTFISVLIFFIRMKQYHTRSYQYGSIAKQCERMYALLAICTTLSPGPSDESIMSIVKEHYADQLAILQRGGDEALETFKDLFLSASPKYLNVNPPPYEDPSALEAYLANPPIDATQRFLDLFISDVVAVKGVSNVRQLLKLYTSIDASKLVTFSQDEGDEEEVLQQLMVLKAASRTYAKGQAQDKLLDGERIVTNNLDFTIDGAMVHVEETTSHRRFAGFFIRNAEHSQRVFNTIKASPLPIQRKPATATTGAPQDKNEIKKTGAAWQPKRARVVTAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I2Y1</accession>
    <name>A0A1B9I2Y1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Anaphase-promoting complex subunit 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_04433</name>
        <name evidence="6" type="ORF">I206_103993</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the APC3/CDC27 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011121.1">
        <property type="nucleotide sequence ID" value="XM_019156163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I2Y1"/>
    <dbReference type="STRING" id="1296096.A0A1B9I2Y1"/>
    <dbReference type="GeneID" id="30172802"/>
    <dbReference type="KEGG" id="kpin:30172802"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF13">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="492"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="560"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="628"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="662"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="730"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I383</accession>
    <name>A0A1B9I383_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_04547</name>
        <name evidence="5" type="ORF">I206_103880</name>
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        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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            <begin position="1"/>
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        </location>
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        </location>
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        </location>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF50016.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC69936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
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    </evidence>
    <sequence length="267" mass="26749" checksum="95D86B1835600ED6" modified="2016-11-02" version="1">MLSFGLFLALIPLIYRVKAQDQASNGTSPAEGQNGAPDLSQYPQWITNDYQCVIGCLSGFNDTITIIPQPDLENAAFTCASTNCAGDGTGNYYQTLYYIQLFYATGSIYEWSDSAPDGYKHATFSNGDEVQSSASVAQATASDPWSVDVAEKTGGAGIVEPSAVSATSGVSAISVASGTASASAGVNNGGSDTISSTSDEGSTGSHTGSSAKPSGTNGTSNGTADRNSSSGALPLVIAGSGVMGLPTLVGMVFGVGVAVVGGVFTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I389</accession>
    <name>A0A1B9I389_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mediator complex subunit 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MED10</name>
        <name evidence="8" type="ORF">I206_04534</name>
        <name evidence="9" type="ORF">I206_103893</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 10 family.</text>
    </comment>
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        <property type="protein sequence ID" value="OCF50003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC69949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011222.1">
        <property type="nucleotide sequence ID" value="XM_019156264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I389"/>
    <dbReference type="STRING" id="1296096.A0A1B9I389"/>
    <dbReference type="GeneID" id="30172903"/>
    <dbReference type="KEGG" id="kpin:30172903"/>
    <dbReference type="OrthoDB" id="337270at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019145">
        <property type="entry name" value="Mediator_Med10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09748">
        <property type="entry name" value="Med10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="151"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF50003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC69949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="207" mass="22460" checksum="B90245C8A21C16BC" modified="2016-11-02" version="1">MSLGAPQLPSPAPTPGSGLGMVSQPSPDGPPDQSALRTELESQLLRLTQDLYELEICAGDVGPGMEDAVPKYLMKVNQGFINLERIAGQLGDSVPHQIVDNIDRYKNPHVFTKNTLTRAVGENQYALGRVLGLESFRRQLHDALKDEFPDVPLPGRRHEPDIPAIVQNDNETLSDGYSRSTQVNGDVDVKVEEDNGLPDGNAKSGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I3E3</accession>
    <name>A0A1B9I3E3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein CPL1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_03372</name>
        <name evidence="4" type="ORF">I206_105725</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011275.1">
        <property type="nucleotide sequence ID" value="XM_019155121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I3E3"/>
    <dbReference type="STRING" id="1296096.A0A1B9I3E3"/>
    <dbReference type="GeneID" id="30171741"/>
    <dbReference type="KEGG" id="kpin:30171741"/>
    <dbReference type="OrthoDB" id="439917at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048661">
        <property type="entry name" value="CPL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038955">
        <property type="entry name" value="PriA/CPL1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192:SF2">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21671">
        <property type="entry name" value="CPL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628349" description="Protein CPL1-like domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Protein CPL1-like" evidence="2">
        <location>
            <begin position="236"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF50056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC71766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="322" mass="34822" checksum="30E7EA7E03A1A2CB" modified="2016-11-02" version="1">MSTSCIIVALTILSTIPSLVFAATYNSIFATCAGSGYVPNGGAQSGAWSSASACAAYCYARDTSYIYSAWTSTTSGCSCGSNSFQTGSVAYGNPGNCGGNYEVSITHTTFNFISCTNTYQFTGAIIQSSSTDFFAIFNQCRSYRYMAIWPTSGNTFLYACGSAYTLPSTQTCDYQVNRLYSHPADATASQLARREQVETAKRRLDSLNQQESMSMKDQWCPRGFTSCQLEDDPNSFECVDTMNDLESCGGCLYNPYSPENTGQKDNATISAGQDCSAIPGVALGHSSCDQGRCKFDCKIGWKSDKNKCVKFWKTTYSTKSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I410</accession>
    <name>A0A1B9I410_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Kinetochore protein SPC25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_03574</name>
        <name evidence="13" type="ORF">I206_105524</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Chromosome</location>
            <location evidence="9">Centromere</location>
            <location evidence="9">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the SPC25 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011474.1">
        <property type="nucleotide sequence ID" value="XM_019155320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I410"/>
    <dbReference type="STRING" id="1296096.A0A1B9I410"/>
    <dbReference type="GeneID" id="30171943"/>
    <dbReference type="KEGG" id="kpin:30171943"/>
    <dbReference type="OrthoDB" id="4056921at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23784">
        <property type="entry name" value="RWD_Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.457.50:FF:000001">
        <property type="entry name" value="Probable kinetochore protein spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.50">
        <property type="entry name" value="Chromosome segregation protein Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045143">
        <property type="entry name" value="Spc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013255">
        <property type="entry name" value="Spc25_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14281:SF0">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14281">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC25-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08234">
        <property type="entry name" value="Spindle_Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 9" id="KW-0137">Centromere</keyword>
    <keyword evidence="2 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="4 9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromosome segregation protein Spc25 C-terminal" evidence="11">
        <location>
            <begin position="179"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="119"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="132"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCF50255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC71566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="310" mass="35297" checksum="239F509E3524B5B2" modified="2016-11-02" version="1">MPPPPAYLPRPISLQAILDESSSNSTSPSIDLQWEPFQKHVESFLNAIDAYTIAAKTEIAARATDHVNTMRDLKAEKEETERRIHLEREREGEMLATLETERHTLTDLTSSLNHLQSSLQKVKDQSSSLENEINHLRKSNTSEKTEKDRQQSRLNEMRKRDEDELIELEESIGLRVEAVKRDLLMIRFTLLDPTDPQREFSFLIDISKQDYSVPNCDPPLANLPDLLQQLNHDREFFAFIKRVRKSFRALIPIPAPSTKFDELSGPGLGLRTPAPPTLLGSRILSSSTRENVVVDSHAIESLSLTNRIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I4D1</accession>
    <name>A0A1B9I4D1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal protein S9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_03699</name>
        <name evidence="7" type="ORF">I206_105394</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011597.1">
        <property type="nucleotide sequence ID" value="XM_019155443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I4D1"/>
    <dbReference type="STRING" id="1296096.A0A1B9I4D1"/>
    <dbReference type="GeneID" id="30172068"/>
    <dbReference type="KEGG" id="kpin:30172068"/>
    <dbReference type="OrthoDB" id="10254627at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCF50378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC71438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="38866" checksum="BEEA3FC3D1343710" modified="2016-11-02" version="1">MSLPIASSSIRSLRSIPLRPIFRSYASLTPYSPPITSDYTSNKRPNRPNSSEFFTGRPKFNESLNELKETINLIQKKLRKKFVYPLPNELPNLNPPQTNWLNKEELSNLLDIKLKTNTLRQVIELLNELNHLRYISELSEQFDLVKEINIILNNYERLNSSNISLLSEVEKEKGLTIKEEEELNGIDEFGRSYSMGRKKTSSSRIWLIPSNKFREIENSINENENEITNNKLEQSQVLINHIPLSQYFIRPSDRETILRPLKITGYLGAFNIFGFSRGGGMSSQASSVGLAIARALSNLKDDAKDILQADGALMRDTRTTERKKTGRAKARKGYTWVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I4N7</accession>
    <name>A0A1B9I4N7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcium-binding protein NCS-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_03800</name>
        <name evidence="10" type="ORF">I206_105291</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the recoverin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011695.1">
        <property type="nucleotide sequence ID" value="XM_019155541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I4N7"/>
    <dbReference type="STRING" id="1296096.A0A1B9I4N7"/>
    <dbReference type="GeneID" id="30172169"/>
    <dbReference type="KEGG" id="kpin:30172169"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Murphy C."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
                <person name="Sun S."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Chapman S.B."/>
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                <person name="Goldberg J."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </source>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
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                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
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</entry>
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                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
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                <person name="Young S.K."/>
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                <person name="Griggs A."/>
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                <person name="Hansen M."/>
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                <person name="Imamovic A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
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                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
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                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
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                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Pearson M."/>
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                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF50668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC68448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="419" mass="47153" checksum="72F29E0CBD54F062" modified="2016-11-02" version="1">MPYIQVPDTSFDLFYRLSTPLRSNQATSIEEEYETILLFHPYWVDSFYFYPQFDDPSFNENYNIIAFDAPAHGSTKAKGISSEPVTWSYFASIVKDALTILKIPAVHVIGSTMGCCAAMHFASKYPEITKTLTMSAPPALEEATNWSLTFRECMHILINSVKTNDPEPLDAITSVIFDYNATSHSSQVLKDLEEEYCQSIRSRLLRGELNGEMTVPILISLALSRKHLLSLDEMVNLKPPVLIIQGTNEGWEASDDQWAKILEESDQIHRQKYGKGLNIKRMVLDDLPRWMSLTCPETVNPIIKGFVRTGSSGDVSSLAEFEVDQSTSTDTTMRMISTTRRRLSINPPKPRLPFSRTDPIDVGPVRQETVGSDKPDLMANKRFYSGSRHVNIPSNTRSGKNRSSSIDINVHVDVVTKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I5E6</accession>
    <name>A0A1B9I5E6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Endoglucanase</fullName>
            <ecNumber evidence="9">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I206_02810</name>
        <name evidence="14" type="ORF">I206_102460</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the glycosyl hydrolase 9 (cellulase E) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="9"/>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF50754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011973.1">
        <property type="nucleotide sequence ID" value="XM_019154570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I5E6"/>
    <dbReference type="STRING" id="1296096.A0A1B9I5E6"/>
    <dbReference type="GeneID" id="30171179"/>
    <dbReference type="KEGG" id="kpin:30171179"/>
    <dbReference type="OrthoDB" id="10257085at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001701">
        <property type="entry name" value="Glyco_hydro_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033126">
        <property type="entry name" value="Glyco_hydro_9_Asp/Glu_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22298">
        <property type="entry name" value="ENDO-1,4-BETA-GLUCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00759">
        <property type="entry name" value="Glyco_hydro_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00698">
        <property type="entry name" value="GH9_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6 8 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008448413" description="Endoglucanase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="557"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 9" evidence="12">
        <location>
            <begin position="49"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="489"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCF50754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WWC68531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="592" mass="64128" checksum="9FBD56C70AB13474" modified="2016-11-02" version="1">MIPLHLISVIPFLLSPHISAQLTPSPTYTPPTASSGLASSTSTPNTQWSNILGNSLYFYDAQRSGKLNEGTYGNRVEWRNDSALQDGSDWNLDLTGGWYDAGDYIKATFPLTFTLFALAWGALTHGEGFDQAQQTAYLDGTLRWGYDWLIKAHPSDDVLFVQVGSGDVDNAYWGGDENIPGPRPAYPINSSFPGTDAWSSAAAAFALGSVLYTPSISYNVTSSSSAPSSIGNATYSASLLSQAKTLYNVANSTSNKTTYYDSLGGSVSAYASSNWADDFTLSSLALAIATNESTYYADAYNNYVSYAISGQQQVWNWDSAIPAIYVLFAEIAHARPGLAAGAGLDRNLTGWQNETEKLFDSIIDGSFKRSYLTRGGLLYFEGDSDEASLNPATAIAMLMFKYAPIASSQDKTERYNNFAQGQLNYMLGKNPMNAVYLVGSHPNSPQNPHSAPASGGNNIKEIRTSPPTEAYVIYGAMVGGPLSDDRFWDWRDDWVQNEVALDYNAMIPTLAAMQILNQTSDPPYVSIQAGTYSIPSEQPCDAALPCEGGGLSKGAKAGIAIGVIVGVLLILAAIWYWKRKQIGAWWRKGYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I5M2</accession>
    <name>A0A1B9I5M2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Xylitol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_02859</name>
        <name evidence="11" type="ORF">I206_102508</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF50802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012021.1">
        <property type="nucleotide sequence ID" value="XM_019154618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I5M2"/>
    <dbReference type="STRING" id="1296096.A0A1B9I5M2"/>
    <dbReference type="GeneID" id="30171228"/>
    <dbReference type="KEGG" id="kpin:30171228"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="9">
        <location>
            <begin position="68"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="8">
        <location>
            <begin position="324"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="263"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF50802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC68578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="448" mass="48229" checksum="ACE51A2B1D8A7CA8" modified="2016-11-02" version="1">MAEFHFLNTVQPKQVTSLNLPPNHSCNLVAKRKIEVRPNDMPILQPDGVLVKVISTDKQANICAFLRICGSDLHNYLAGGVGGRPVQYPIVMGHESSGEVIAVGELIKSHKIGDRVAIEPGLPCRRCINCKEGKVNICLDMRYCGAPGSVGSLSRYFALPADMAPHIPDHVTWDEAGCIQPLAVGVQIGKRVDLRPHKTLAIFGCGPIGLITAAVAHAYSARKIIAFDNNLKRVEFAKKYKSPLTGKPIIDHVFHIKDLPTESLQPKQQQQQQQQQNGSLANKLGENGSGGGGIGDGEINDHEIETLGDKKWEQAKKIAAEFVEIAGLTAEEGVDRVVEATGAEDCMLLGIAIAKQGGNYLAVGLGHIQTNCFPTLAVTNKEINVMGITRYTASCFPSALDMLSRGVVDIKQLITRTFPLSQATDAFEAVAAGGDMKVVVKNQEGFDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I5U7</accession>
    <name>A0A1B9I5U7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="7">PPIase</shortName>
            <ecNumber evidence="7">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_02956</name>
        <name evidence="10" type="ORF">I206_102602</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="7"/>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF50895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012114.1">
        <property type="nucleotide sequence ID" value="XM_019154711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I5U7"/>
    <dbReference type="STRING" id="1296096.A0A1B9I5U7"/>
    <dbReference type="GeneID" id="30171325"/>
    <dbReference type="KEGG" id="kpin:30171325"/>
    <dbReference type="OrthoDB" id="271386at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000008">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="8">
        <location>
            <begin position="5"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>cyclosporin A</name>
            <dbReference type="ChEBI" id="CHEBI:4031"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="65"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>cyclosporin A</name>
            <dbReference type="ChEBI" id="CHEBI:4031"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="94"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>cyclosporin A</name>
            <dbReference type="ChEBI" id="CHEBI:4031"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="104"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>cyclosporin A</name>
            <dbReference type="ChEBI" id="CHEBI:4031"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>cyclosporin A</name>
            <dbReference type="ChEBI" id="CHEBI:4031"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>cyclosporin A</name>
            <dbReference type="ChEBI" id="CHEBI:4031"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001467-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCF50895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC68669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="176" mass="18949" checksum="43D31E59DB9A8DCB" modified="2016-11-02" version="1">MSSQKAEYVTFDTSVGSFTVELYTAHAPRTCNNFSKLAERGYYNGVIFHRIIPGFMIQGGDPTGTGRGGTSIYGDKFTDELHPDLRFVGAGILAMANSGPNTNGSQFFITCAPTPFLDGKHTIFGRISSGMKTVQRLEAVRTDSEDRPVEDIKIHKARLGDAAPPSGGMDVAKIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I5X7</accession>
    <name>A0A1B9I5X7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH-ubiquinone oxidoreductase 49 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_02974</name>
        <name evidence="8" type="ORF">I206_102620</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF50912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012131.1">
        <property type="nucleotide sequence ID" value="XM_019154728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I5X7"/>
    <dbReference type="STRING" id="1296096.A0A1B9I5X7"/>
    <dbReference type="GeneID" id="30171343"/>
    <dbReference type="KEGG" id="kpin:30171343"/>
    <dbReference type="OrthoDB" id="1009at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.645.10:FF:000005">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="entry name" value="Cytochrome-c3 Hydrogenase, chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01358">
        <property type="entry name" value="NDH1_NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01962">
        <property type="entry name" value="NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004739">
        <property type="entry name" value="PRK06075.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 49 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="HydB/Nqo4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADH-quinone oxidoreductase subunit D" evidence="6">
        <location>
            <begin position="187"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCF50912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC68686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="457" mass="51695" checksum="E2F3CE267E78E681" modified="2016-11-02" version="1">MIRNLRPIIRNVSSSSSSKSQFRLISNSTLRSMATPAVEPSPVRAHSVEELHSLSAEEILKEGTSRKDAQMRHFTVNFGPQHPAAHGVLRLILELNGEEILRADPHIGLLHRGTEKLIEYKNYTQALPYFDRLDYVSMMTNELSYTLAVEKLLNIEVPERAKWIRTLFGEITRVLNHLMAVLTHAMDVGALTPFLWGFEEREKLMEFYERVSGARMHAAYIRPGGVAFDLPHGMLDDIFKWATQFSSRVDEIEEVVTGNRIWKGRTIGIGTVTAQQALDYSFSGVMLRGSGVPWDIRKVAPYDAYDKVEFDIPVGKNGDCYDRYLCRVQEFRESLRIIDQCLNKMPTGAVKVDDHKIVPPPRASMKESMEALIHHFKIFSEGYTVPPGETYSSIEAPKGEMGVYLVSDGSNRPYKCKIRAPGFAHLQGSDFMMRHQFLPDAVAIIGTMDLVFGEVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I674</accession>
    <name>A0A1B9I674_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_03089</name>
        <name evidence="12" type="ORF">I206_102734</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF51024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012243.1">
        <property type="nucleotide sequence ID" value="XM_019154840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I674"/>
    <dbReference type="STRING" id="1296096.A0A1B9I674"/>
    <dbReference type="GeneID" id="30171458"/>
    <dbReference type="KEGG" id="kpin:30171458"/>
    <dbReference type="OrthoDB" id="10249309at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1070">
        <property type="entry name" value="Translation initiation factor eIF-2B, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051501">
        <property type="entry name" value="eIF2B_alpha/beta/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042528">
        <property type="entry name" value="elF-2B_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0396">Initiation factor</keyword>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
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                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
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                <person name="Zeng Q."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="Zeng Q."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
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                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
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                <person name="Cuomo C.A."/>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mohammad A.W."/>
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                <person name="Yurkov A.M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I6J3</accession>
    <name>A0A1B9I6J3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">30S small subunit ribosomal protein S8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_03216</name>
        <name evidence="5" type="ORF">I206_102866</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF51150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC68930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019154966.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="30171585"/>
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    <dbReference type="OrthoDB" id="409928at2759"/>
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        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Mitochondrial 40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF51150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC68930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="167" mass="17869" checksum="90A7539A4B117B93" modified="2016-11-02" version="1">MTTRSLGPLPANLCAHLQNTSRGFQAKTSVPFSTSSLAISSILLRSGLISNVSLGSPAGPDPTSFNSLPIPARKLWIGLKHRNGQPVLRRMGLVSKPSFRVVVDRDELGRLLVGKRARNVAGVGMGEILIVRTAEDAKNGRTGTNRFLEGWEAWRAGLGGEVICRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I6W9</accession>
    <name>A0A1B9I6W9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_02007</name>
        <name evidence="4" type="ORF">I206_104477</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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            <strain evidence="3">CBS 10737</strain>
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            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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</entry>
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    <accession>A0A1B9I757</accession>
    <name>A0A1B9I757_9TREE</name>
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        <recommendedName>
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    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
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    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="6">CBS 10737</strain>
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    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <location>
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    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
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    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF51375.1"/>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
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    </evidence>
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</entry>
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    <name>A0A1B9I7D7_9TREE</name>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
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                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
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                <person name="David-Palma M."/>
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                <person name="Mohammad A.W."/>
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                <person name="Yurkov A.M."/>
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    <dbReference type="InterPro" id="IPR010828">
        <property type="entry name" value="Atf2/Sli1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037:SF1">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07247">
        <property type="entry name" value="AATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCF51965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC69809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="52586" checksum="CE7BDD8AFF9FEAC9" modified="2016-11-02" version="1">MVRETARLGLSERWSLSRKNVNSPITVIYHASIPADCVAKEDLVEAARKLSEIYPVLSCGVDGASSRTPEYVYRKDLSSADVVKIVNLDKEDSLEQLVNRAVIQGKSYHVDSGALWEIQLHRVSSSTPPSPRDRLVLLIDHILCDGLGARNLFADLLGLLSGIPIPDQPDGLPARMDDTVNLKPALESTEPSIWSYIQPYVGSVARRLSSFLTSPPLYAPFPPRQQPGYNSVTAPQQYSHFDLPSSDLSALLSEGKKHAIPTIHPVLHIAAVIALYRATKSTTGLSFYSSIPISERNPSLGHPRSTGNYVTFHFSTDRINRSTIIWEHARGFSSTLRRPETKLVARQTLGKLDAIDGDHKEDDGPSGWEEHLKKVMSDSLGPHKLSLAVSNVGLMELPSTGKLAGEIQDVYFTQSASAMGGCAVLSILSTRGGSMTVSVSSKIGSLPAGVFEAFAEQLKPIVYAIARGDVGENTQAGDSIAGVPDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I952</accession>
    <name>A0A1B9I952_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_01344</name>
        <name evidence="3" type="ORF">I206_103653</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I952"/>
    <dbReference type="GeneID" id="30169713"/>
    <dbReference type="KEGG" id="kpin:30169713"/>
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        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF52060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC69710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="162" mass="17637" checksum="ED29648405F864CC" modified="2016-11-02" version="1">MPSSQRSDRKSKGGGSSSSASGTSKSTFSSRIAKRVPGGKIDSTMLAKFQQHADVLLDCASASSAGPSKTLADLDTQYDLMTKVQQNEFERKVYETLLEIGIEHEVKTQELMSDIAPTKLSNDSLLQAEIFQDLNNESDEEWSMSGKGEGEDEDEDTKMSGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I9E7</accession>
    <name>A0A1B9I9E7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tubulin-folding cofactor B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_01528</name>
        <name evidence="7" type="ORF">I206_103469</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TBCB family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013461.1">
        <property type="nucleotide sequence ID" value="XM_019153300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I9E7"/>
    <dbReference type="STRING" id="1296096.A0A1B9I9E7"/>
    <dbReference type="GeneID" id="30169897"/>
    <dbReference type="KEGG" id="kpin:30169897"/>
    <dbReference type="OrthoDB" id="5295208at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01789">
        <property type="entry name" value="Ubl_TBCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045172">
        <property type="entry name" value="TBCB_Ubl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF85">
        <property type="entry name" value="TUBULIN-FOLDING COFACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14560">
        <property type="entry name" value="Ubiquitin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="5">
        <location>
            <begin position="177"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCF52242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC69527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="241" mass="26794" checksum="213C0C111647548E" modified="2016-11-02" version="1">MTLISIFVTSPDTHSERRFDSSLTISQLKDKLVPITGISPQYQNLTLYASSDAVLSGKAIISLSEESRTLEEYSVKEWQCIKIDNTDPNYRPGEFTDESNLERFELTNEEYESRNDTVLSHLKANKLGRFAPIPTNLTCQPPIPSTYDSNIIPGSRCRVSHGDSGEGRIGTVRFVGEASIGKGGIWVGVELDEPQGKGDGEVEGNRYFQCSPRHATFVRPEKLTIGDYPEEDLLASDEDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IA76</accession>
    <name>A0A1B9IA76_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">I206_01643</name>
        <name evidence="18" type="ORF">I206_103351</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 14">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013573.1">
        <property type="nucleotide sequence ID" value="XM_019153412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IA76"/>
    <dbReference type="STRING" id="1296096.A0A1B9IA76"/>
    <dbReference type="GeneID" id="30170012"/>
    <dbReference type="KEGG" id="kpin:30170012"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000008">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 14" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="15">
        <location>
            <begin position="48"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="16">
        <location>
            <begin position="247"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OCF52354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="WWC69412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="448" mass="49462" checksum="4D003652F9C6BBA0" modified="2016-11-02" version="1">MREVISVHVGQAGVQIGNACWELYTLEHGLSPDGRLIEGSPHGGDDGFSTFFSETGSGKHVPRSLYVDLEPNVVDEVRTGTYRSLFHPETMITGKEDAANNYARGHYTIGKELVDNVLDQVRKLADNCSGLQGFFVFHSFGGGTGSGFGALLMERLSTDYGKKSKLEFSVYPAPKMSTSVVEPYNSVLTTHTTLEHSDCSFMVDNEAIYDICRRNLGITSPSFTNLNRLIAQVVSSITASLRFDGSLNVDLNEFQTNLVPFPRIHFPLATYAPVVSAEKAFHESNSVSEMTISCFESNNQMVKCDPRQGKYMACCLLYRGDVVPKDVNAAVANVRTKRTIQFVDWCPTGFKLGICNEPPALVPGGDLAKVSRSLCMLSNTTSIATAWARLDNKFDLLYSKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGIDSVDVEEEEGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IAA6</accession>
    <name>A0A1B9IAA6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chaperonin GroES</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_01686</name>
        <name evidence="6" type="ORF">I206_103308</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Eukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60. Binds to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GroES chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013616.1">
        <property type="nucleotide sequence ID" value="XM_019153455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IAA6"/>
    <dbReference type="STRING" id="1296096.A0A1B9IAA6"/>
    <dbReference type="GeneID" id="30170055"/>
    <dbReference type="KEGG" id="kpin:30170055"/>
    <dbReference type="OrthoDB" id="184876at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.33.40:FF:000002">
        <property type="entry name" value="10 kDa chaperonin, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="entry name" value="GroES chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772:SF0">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00056825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF52397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC69369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="105" mass="11159" checksum="2803E7A04196DB34" modified="2016-11-02" version="1">MSATFKSIRSLQPLLDRVLVQRFKAETKTATGLFLPSSSTSSPLPEATVIAVGPGAPNKEGVVSPVSVQVGDRVLLPGWGGSPIKVGEEEYHLFKDAEILAKINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IAG7</accession>
    <name>A0A1B9IAG7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">UDP-N-acetylglucosamine transferase subunit ALG13</fullName>
            <ecNumber evidence="4 12">2.4.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Asparagine-linked glycosylation protein 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ALG13</name>
        <name evidence="14" type="ORF">I206_01891</name>
        <name evidence="15" type="ORF">I206_103105</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 12">Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UDP-N-acetyl-alpha-D-glucosamine = an N,N'-diacetylchitobiosyl-diphospho-di-trans,poly-cis-dolichol + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23380"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19510"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57269"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
            <dbReference type="EC" id="2.4.1.141"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Heterodimer with ALG14 to form a functional enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.141" evidence="4 12"/>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013817.1">
        <property type="nucleotide sequence ID" value="XM_019153656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IAG7"/>
    <dbReference type="STRING" id="1296096.A0A1B9IAG7"/>
    <dbReference type="GeneID" id="30170260"/>
    <dbReference type="KEGG" id="kpin:30170260"/>
    <dbReference type="OrthoDB" id="20273at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039042">
        <property type="entry name" value="Alg13-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12867">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12867:SF6">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYLDIPHOSPHODOLICHOL N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 28 C-terminal" evidence="13">
        <location>
            <begin position="4"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCF52598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WWC69169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="186" mass="21196" checksum="505FEAEE6E32D039" modified="2016-11-02" version="1">MTSILITVGSTLFPSLTDKILSSEIISILIENGIEKLIIQYGNANLPFNFKKEINFKNEEKGKGFIKIEEEKLKIELIRFTNDFENLIKNCDFIISHAGSGSILTTLRMIPPKPLLIVPNESLMDNHQSELAEKMKEQGYSEVSSIDDLQVTLPIFLKSRGKKIKSFPQMNRNRFKNILDDLMGFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IAQ1</accession>
    <name>A0A1B9IAQ1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphotyrosine protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_01781</name>
        <name evidence="7" type="ORF">I206_103214</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the low molecular weight phosphotyrosine protein phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013710.1">
        <property type="nucleotide sequence ID" value="XM_019153549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IAQ1"/>
    <dbReference type="STRING" id="1296096.A0A1B9IAQ1"/>
    <dbReference type="GeneID" id="30170150"/>
    <dbReference type="KEGG" id="kpin:30170150"/>
    <dbReference type="OrthoDB" id="3388at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16343">
        <property type="entry name" value="LMWPTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050438">
        <property type="entry name" value="LMW_PTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017867">
        <property type="entry name" value="Tyr_phospatase_low_mol_wt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11717:SF7">
        <property type="entry name" value="LOW MOLECULAR WEIGHT PHOSPHOTYROSINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11717">
        <property type="entry name" value="LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00719">
        <property type="entry name" value="LMWPTPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="Phosphotyrosine protein phosphatases I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphotyrosine protein phosphatase I" evidence="5">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617867-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCF52491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC69276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="151" mass="16947" checksum="1E97F7123E8F7CC3" modified="2016-11-02" version="1">MAEAVLKYEITQRSLKFDITVDSAGTGAYHEGEEADDRTIAVCKKHGIKADSIARAVTKDDFNKFDYILAMDQSNLQTLLNRQPFTSKSKISLFSSFSNLIPNSEKGLSKTKSENINDPYYGGKDGFEISFKKCTEFSKGFLDYLEDKKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IAX2</accession>
    <name>A0A1B9IAX2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_00071</name>
        <name evidence="4" type="ORF">I206_101251</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF52775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013994.1">
        <property type="nucleotide sequence ID" value="XM_019151856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IAX2"/>
    <dbReference type="STRING" id="1296096.A0A1B9IAX2"/>
    <dbReference type="GeneID" id="30168440"/>
    <dbReference type="KEGG" id="kpin:30168440"/>
    <dbReference type="OrthoDB" id="63070at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051859">
        <property type="entry name" value="DCAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847:SF7">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="452"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="634"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="723"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="280"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF52775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC67343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="745" mass="84008" checksum="10EA5BDA54084EF2" modified="2016-11-02" version="1">MADDLHPDLDEFYDTTGGDEDQWEDEDDEESGALRTRNRGPGRGYQVFVDPDDLYDDEDEDDDEDYIFEDDIGEVYEDDEEEEGEEDEDLGNGMIIDNEEDGSAEALREIEALINSRRIGQVRTALTANDEGDSSILQQLLNRGIFRITRGTNIDESLSREAERNRQRSEWKTPPKEPHPNGVGLLKGGEFGRVGQWKAGKNQYGVRRPKMNQPWMNGWSGPKITSASSRAIVPNTSGTIVASYSSIPYVGQYAKEDYSLFYTATQYFTLHLYATNQSKKNHIASNPRKRRRSRSQAAQPSAIAQEEEDDEEEENEDDYETEDSEEEERWGALGGTHFTSSEDSSLKRIKKVQGVEGSWTVTDCDADKKGDKMIYSSITPYVHMLYTNATDQEHVELDFTGRRRDRDAIWGHDRFGIWSIRFSADGKEVVAGARSGRIMVYDIDAQRRTLAIQGHADDVNAVSFADESSTNILVSGSDDGYVKVWDRRSLSSSTPSGILVGATEGITYTSPKGDGRYIIVNSKDQAARLYDLRKMRSANEFDNEPDAVARYGQPRFDYRGMDYAPPTRLAHPKDCSIMTYRGHSVLRTLIRCHFSPRESTGQSYIYSGSADGLIHIWSLDGRLLNRAESLPLRQNSSYSDPSMADPTLPNASGRYQAHHGRNRYASHGMEFAVRDVAWHGYEPTLMSTCWETNRGSRGGNVAKHEWKGLGKNGLNRLEDWVEKRQSENEPSGGTRMPGSVLDWDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IB31</accession>
    <name>A0A1B9IB31_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I206_00172</name>
        <name evidence="17" type="ORF">I206_101154</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine from methionine and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-methionine + ATP + H2O = S-adenosyl-L-methionine + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AdoMet synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF52872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014091.1">
        <property type="nucleotide sequence ID" value="XM_019151953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IB31"/>
    <dbReference type="STRING" id="1296096.A0A1B9IB31"/>
    <dbReference type="GeneID" id="30168541"/>
    <dbReference type="KEGG" id="kpin:30168541"/>
    <dbReference type="OrthoDB" id="5852090at2759"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18079">
        <property type="entry name" value="S-AdoMet_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000001">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000003">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000004">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="S-adenosylmethionine synthetase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-adenosylmethionine synthetase N-terminal" evidence="13">
        <location>
            <begin position="19"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase central" evidence="14">
        <location>
            <begin position="129"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase C-terminal" evidence="15">
        <location>
            <begin position="253"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCF52872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="WWC67247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="396" mass="42824" checksum="7196D2FA1D7D1A30" modified="2016-11-02" version="1">MTGVLNGNGPSAELAPGHFLFTSESVGEGHPDKICDQVSDAILDACLAQDPFSKVACETAAKTGMIMVFGEITTKAQVDYQKVVRDTIKQIGYDSSDKGFDYKTCNVLVAIEQQSPDIAQGLDHGALEKIGAGDQGIMFGYATDETPEMMPLTIMLSHKLNAAMAAARRDGSLGWLRPDSKTQVTVEYKKGEDGAMIPIRVDTVVISTQHAEEITTEDLRSEILEKIIKKVIPANLLDDKVIYHIQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDWSKVDRSAAYTARWIAKSLVAAGLARRALVQLSYAIGVAEPLSIFVDTYGTGKKTDAELVQIVRQNFDLRPGLIVKALNLQQPQYLKTAAYGHFGNPAYSWEQPKQLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IB60</accession>
    <name>A0A1B9IB60_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Dynein light intermediate chain 1, cytosolic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_00082</name>
        <name evidence="12" type="ORF">I206_101240</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">CBS 10737</strain>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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            <strain evidence="11">CBS 10737</strain>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
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                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
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                <person name="Birren B."/>
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    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">CBS 10737</strain>
        </source>
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    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF52863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014082.1">
        <property type="nucleotide sequence ID" value="XM_019151944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IBQ7"/>
    <dbReference type="STRING" id="1296096.A0A1B9IBQ7"/>
    <dbReference type="GeneID" id="30168532"/>
    <dbReference type="KEGG" id="kpin:30168532"/>
    <dbReference type="OrthoDB" id="1915122at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040153">
        <property type="entry name" value="Rcf2"/>
    </dbReference>
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        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="6">
        <location>
            <begin position="90"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCF52863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC67256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="234" mass="25836" checksum="FD377361CE950BA1" modified="2016-11-02" version="1">MKLASTEDIQAYNDATINGGIRGIMYGIGLSVPGFYLLNKRVAAYRSLPTPLKAAGYVMVIVPCISITAEKQGEAFTRSQYSGVAKLELDREAEIEHQRWQSLSSVQKLGDWAARHKYQLVGASWVGSLGAAWALVNRNKFQSTSQKVVQARMWAQGLTVGLLMVSALLTGFDSSKSEEPRAPHEDHTWKAILEADPHLNAEERKQLHEITQAVKERKDQLVQGASDAISTKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9ICD5</accession>
    <name>A0A1B9ICD5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rubisco LSMT substrate-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_00434</name>
        <name evidence="6" type="ORF">I206_100892</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014352.1">
        <property type="nucleotide sequence ID" value="XM_019152214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9ICD5"/>
    <dbReference type="STRING" id="1296096.A0A1B9ICD5"/>
    <dbReference type="GeneID" id="30168803"/>
    <dbReference type="KEGG" id="kpin:30168803"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1420.10">
        <property type="entry name" value="Rubisco LSMT, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015353">
        <property type="entry name" value="Rubisco_LSMT_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036464">
        <property type="entry name" value="Rubisco_LSMT_subst-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF34">
        <property type="entry name" value="N-LYSINE METHYLTRANSFERASE SETD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09273">
        <property type="entry name" value="Rubis-subs-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81822">
        <property type="entry name" value="RuBisCo LSMT C-terminal, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rubisco LSMT substrate-binding" evidence="4">
        <location>
            <begin position="358"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF53133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC66985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="503" mass="57487" checksum="F0C87E5B8A5F91DC" modified="2016-11-02" version="1">MTLYDPAVSIECEKKTFNPEQFLEWFEKAGGWYDSKYLGLKPFSGMGYGAVALDNVPEDIPLFHVPDSLILSPYTSELSKHLSQEEWERIDRGWDRLILVMMWESGRGKDSPWSSYLSNMPSEFDTPMMWNEEERKELVGTDIEDRIGREDAEKEYSEYLLPIIQAHPNLFPPDSTDHSLESFHIQGSRILSRSFTVPSSRFGESTIRDDSDLSDDEDEEGEQIVVMIPFADMLNAGYERDNANLFTDEKTKEEGGQWDKRGFTMKSTKPMMKDEQIFNTYASPPNSELLRKYGHVDIIPIPDEQIELLNKEEMGDWPFGNPGDEILIDGKIIVKSVEKVLGKKKGDEEKWQAKVSKRVDWWLEEGLDDMFPLTLSPEFDDEFIAFIRLLLYDSEWLRAKKKGKLPTTTIDKEVASVIVGAVQSRLSRYTSNVKSDLEVITSVPSSHISRLVSSTSATLQSGINDTTILRKAYAAIVRLGEKRILQVASRNAEKHLPQKRKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9ICK6</accession>
    <name>A0A1B9ICK6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_00680</name>
        <name evidence="4" type="ORF">I206_100645</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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            <end position="97"/>
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    </feature>
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        <location>
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    </evidence>
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</entry>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Chromosome 1"/>
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        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:protein modification by small protein removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
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        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
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    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
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    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF7">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE 1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08324">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="7">
        <location>
            <begin position="2"/>
            <end position="142"/>
        </location>
    </feature>
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        <location>
            <begin position="206"/>
            <end position="336"/>
        </location>
    </feature>
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        <location>
            <begin position="353"/>
            <end position="646"/>
        </location>
    </feature>
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        <location>
            <begin position="149"/>
            <end position="182"/>
        </location>
    </feature>
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        <location>
            <begin position="196"/>
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        </location>
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        </location>
    </feature>
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            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
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    <name>A0A1B9ICR7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Glutathione S-transferase omega-like 2</fullName>
            <ecNumber evidence="3">1.8.5.1</ecNumber>
            <ecNumber evidence="4">2.5.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glutathione-dependent dehydroascorbate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">I206_00492</name>
        <name evidence="19" type="ORF">I206_100834</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Active as '1-Cys' thiol transferase against beta-hydroxyethyl disulfide (HED), as dehydroascorbate reductase and as dimethylarsinic acid reductase, while not active against the standard GST substrate 1-chloro-2,4-dinitrobenzene (CDNB). May be involved in cell wall organization and biogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate</text>
            <dbReference type="Rhea" id="RHEA:24424"/>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:58539"/>
            <dbReference type="EC" id="1.8.5.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 21">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GST superfamily. Omega family.</text>
    </comment>
    <dbReference type="EC" id="1.8.5.1" evidence="3"/>
    <dbReference type="EC" id="2.5.1.18" evidence="4"/>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014410.1">
        <property type="nucleotide sequence ID" value="XM_019152272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9ICR7"/>
    <dbReference type="STRING" id="1296096.A0A1B9ICR7"/>
    <dbReference type="GeneID" id="30168861"/>
    <dbReference type="KEGG" id="kpin:30168861"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045174">
        <property type="term" value="F:glutathione dehydrogenase (ascorbate) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03190">
        <property type="entry name" value="GST_C_Omega_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000162">
        <property type="entry name" value="Glutathione S-transferase Gst3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000038">
        <property type="entry name" value="Glutathione S-transferase omega-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047047">
        <property type="entry name" value="GST_Omega-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016639">
        <property type="entry name" value="GST_Omega/GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419">
        <property type="entry name" value="GLUTATHIONYL-HYDROQUINONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015753">
        <property type="entry name" value="GST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01206">
        <property type="entry name" value="Xi.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01148">
        <property type="entry name" value="Xi_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST C-terminal" evidence="17">
        <location>
            <begin position="176"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="14">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="131"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="149"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="16">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="16">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00055859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00070045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OCF53191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="WWC66927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="329" mass="38337" checksum="C7C353ED43BB41FC" modified="2016-11-02" version="1">MNNAQKDITSWADKSGSFKRQVSSFRDIIEPNGQFPPEKGRYHLYVSLACPWAHRALIVRQLKGLEDFFDVSTVHPHMLEKGWHFAKSSENPAPQSEHSDDTFPAATVDNLFGVSHLRELYFKVEPDYQARFTVPVIWDKKTNKIVNNESSEIIRFLNTAFNDQLSGEQQSLDLYPKELQKEIDGLNEWVYNDINNGVYKSGFATTQEAYEAAVKPLAEGLEKVEKILSDGRDFLIGGRLTEADVRLYTTIIRYDPVYYVHFKCNLGLIRHDYPHLHKWLQRLYWKNPAFKDTTNFEHIKEHYYYSHKHINPNRIVPYGPNVDIEPLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9ICT3</accession>
    <name>A0A1B9ICT3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">DNA polymerase epsilon catalytic subunit</fullName>
            <ecNumber evidence="19">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">I206_00758</name>
        <name evidence="23" type="ORF">I206_100567</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="23" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17 19">DNA polymerase II participates in chromosomal DNA replication.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="18">Heterotetramer. Consists of 4 subunits: POL2, DPB2, DPB3 and DPB4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 19">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="19"/>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014674.1">
        <property type="nucleotide sequence ID" value="XM_019152536.1"/>
    </dbReference>
    <dbReference type="STRING" id="1296096.A0A1B9ICT3"/>
    <dbReference type="GeneID" id="30169127"/>
    <dbReference type="KEGG" id="kpin:30169127"/>
    <dbReference type="OrthoDB" id="10060449at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05779">
        <property type="entry name" value="DNA_polB_epsilon_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05535">
        <property type="entry name" value="POLBc_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000002">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000005">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000010">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1600.10:FF:000006">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013697">
        <property type="entry name" value="DNA_pol_e_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029703">
        <property type="entry name" value="POL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055191">
        <property type="entry name" value="POL2_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054475">
        <property type="entry name" value="Znf-DPOE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08490">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22634">
        <property type="entry name" value="POL2_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22912">
        <property type="entry name" value="zf-DPOE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23250">
        <property type="entry name" value="zf_DPOE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01159">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 19" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 19" id="KW-0235">DNA replication</keyword>
    <keyword evidence="14 19" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 19" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="12 19" id="KW-0408">Iron</keyword>
    <keyword evidence="13 19" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 19" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 19" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase epsilon catalytic subunit A C-terminal" evidence="21">
        <location>
            <begin position="1518"/>
            <end position="1908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00057054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00065544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU365029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM01159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="OCF53455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="WWC66663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="2251" mass="257251" checksum="563A81BBFD63119D" modified="2016-11-02" version="1">MSFRGSFRGRGKGGNGSNTRFTGKKRSNRGGGVAYGIDRPAPKREDDGTAIAEKFEEIKVQDEIDEKLGFWRFESSRADGEKKIGWLVNMHQTLVQSSTIAGGLAAVDFYFIQDDGGMFKATIPYEPYFYVTCRAGTETMVEEWLLKRFEGVLVRVEREKKWDLSLPNHLLSAPPIFLKLFFHNTSDLHSIRREILPLAEANSAKFTAVDAYADVVGAENAMNGHGDDQGEKAWGAEDESRKRRDREPSECIIDIREHDINYYLRVAIDLDVRVGLWYNVISHTGVISLERITSLVKRAEPVVMAYDIETTKQPLKFPDQQTDQIMMISYMIDGQGYLITNREIVSEDIDDFEYTPKEEYPGDFTIFNEPDEPAVIRRWFEHIRDSKPTVMVTYNGDSFDFPFVDVRAKIHGISMYNEIGFKPDIEDEYKCRGIIHMDCFRWVKRDSYLPQGSQGLKAVTKAKLGYNPTELDPELMTPYAIEQPHSLAQYSVSDAVATYYLYMKYVHPFVFSLCNIIPLNPDEVLRKGSGTLCETLLMVEAYQAHIIMPNRHEDPHGMTYEGHLLASETYVGGHVEALEAGVFRSDIPTHFKMEPSACQQLIDDLDAALKFSLIEEGNIKLEDVDNYDEVKDQIQTALELMRDNPNRMDKPLIYHLDVAAMYPNIMLSNRLQPDSMKDEAACAVCDYNRPDKTCDRRLEWAWRGEYFPAKRDEVNMVRYALEQEMFPPKHPNGPKRRFIDLPQGDQSALIHKRLGDYSRKVYRKTHETKIITKTSIICQRENSFYIDTVRAFRDRRYEYKGLHKTWKKNLDKAIDEGGAVSAVDEAKKMIVLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGITCLTGASIIQMARQLVEQIGRPLELDTDGIWCMLPGVFPEDFKFKLKNGKSFGVSYPCTMLNHLVHAQFTNDQYHELVDKESGKYEVRKENSIFFELDGPYKAMILPSSKEEDKLLKKRYAVFNPDGSLAELKGFEVKRRGELQLIKIFQSQIFDKFLLGTTTEECYAAVAEVADQWLDILQSKAASLDDDELVELIAENRSMSKTLAEYGTQKSTSISTARRLAEFLGEQMVKDKGLSCKFIISAKPNGAPVTERAIPVAIFTAEEPVKRHFLKKWLKDNSLTDFDLRTILDWAYYTERLGSVIQKLITIPAALQKVANPVPRIRHPDWLFKRVAAKEDKFQQHKLTDMFARMRTEIRPTNGNGDIEDMGKNKTGPKMAVVKKKKIVREKTPESVPDPNEDYSSYIRVMKSQWRKQRIERARARKQRPRQDGTVSSMLQTRTINLASRQWDVIQIATTNRPGEFKLWLAIDGTFQSVRLRIPREFYLNFKTLPVEGTFSDRYETTSVARVLPRGQAARHLFRLLVDEALYVEGESHFSSMINNPNVDGAYELQVPLVVRALLHFGTSCTLKTTSLGGLNRGLDKGFDLSELERPGMSVLRHKYLDEGKNIKYHFLYHATFNSRHLIALFSLGQPVRTYVVDASRAPERLPNPSRWYTERLEKAPKGIFNYEEAIEFVTNYYKTELSALKQLSRDLQSIRHGLNVITLCSPFEHSYYQVVSPVFSEFPFITFKGLDEKPSLGWLVQTSRRMINQYLKLSSWIKDQIEIAAHYDVPIGNLGQDAPIFLADIEFARRLKQQDMVLWWSASSRPDLGGSEEDANLSEELVTPRMSTKGCYSSVVLEMEIADLAINAVLQSALVNEMEGSGAGSLAFDSASHNLDEYAKGTANTSVMLGDAVLSTQTFGVLKSMVRSWFLEKARAHVKGIYSTPADLVVDQFWRWISSSSSNMFEPALQRFLHGLMRKTFLQLLAELKRLGTQVVYADFNRIFLLTTKPDAGSAYAFAKYLVTAANSQELFRHLVIDVTQFWNYLAWMDIANFGGVKVSPEIASSRNPPASRFEISMDWNIQSFLPGILQPFFERNVADFIFKLYGAKRSSHDEREPLKVIHNLNIDLPGENTSTINPAKEKEFAMGKKSISHDLTKKLLKDIMSVKKLQIQSHTDEIAAESLLFPSLPGSRFDLYSKTIRLNPVLELTKSILEVFGLDKEHMIEIQILKKNLLDLIGIKEFSSESIFHNPCAASTNDDLKINLIICKKCNSLRDIDLCRDPDRLPSWDNDNKEMLSPPRKNWVCHKCDSEYDKFQIEQPLIENISKMITSYQTQDVICMKCSSSKSDNLASTCHCGGSFKSSLNKNEMKLRLRMIKSVAIYHELPLVGSYVEEVLSRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IDD2</accession>
    <name>A0A1B9IDD2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="3">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Nuclear thiol peroxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I206_01004</name>
        <name evidence="17" type="ORF">I206_100321</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peroxiredoxin family. BCP/PrxQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="3"/>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014917.1">
        <property type="nucleotide sequence ID" value="XM_019152779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IDD2"/>
    <dbReference type="STRING" id="1296096.A0A1B9IDD2"/>
    <dbReference type="GeneID" id="30169373"/>
    <dbReference type="KEGG" id="kpin:30169373"/>
    <dbReference type="OrthoDB" id="338622at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03017">
        <property type="entry name" value="PRX_BCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000157">
        <property type="entry name" value="DOT5p Nuclear thiol peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050924">
        <property type="entry name" value="Peroxiredoxin_BCP/PrxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801:SF23">
        <property type="entry name" value="PEROXIREDOXIN DOT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="15">
        <location>
            <begin position="113"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCF53698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="WWC66419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="261" mass="28186" checksum="8C9F0156DD03E1F9" modified="2016-11-02" version="1">MAPKSSTSAAPPSSRRSARIADQPKSSSGSAPANGDGKVTSKKETVSKKEPNSKKRTAEETNGATETKKTKAEEPKSKSTKTASKKEDSKAEAEKKEEAPASAKADTGSKGALKVGDKLPKITLKDNEGTDIDVSSLAGDKGVVIFLYPKADTPGCTTQACGYRDHLKEIQDHGYDIYGLSKDKSEAQQKWINKKNLTYKLLCDPESKLIKRLGAFVQPNNTKRSHFIFEKGTGKLVDIALGVKPADDPTNVLKFLDKHHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8KY86</accession>
    <name>A0AAJ8KY86_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_100578</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058335.1">
        <property type="nucleotide sequence ID" value="XM_070202234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8KY86"/>
    <dbReference type="GeneID" id="30169116"/>
    <dbReference type="KEGG" id="kpin:30169116"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF5">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="5">
        <location>
            <begin position="65"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC66674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="349" mass="38937" checksum="97942763EE334C92" modified="2024-07-24" version="1">MSDAYTLDDPRIKPVPLQQYPWSPLPQAKSKDRIVKVSIIPTATLSAPVKVFSAFAKGDEKEDSPCWSFLIEKGDDAILWDMGLRQDPQNAPKKIVDGPLKEFVPHTGPGPIARLRKHGYDLGKLGLVVFSHQHFDRPDSLESMQPGFPEDVNSAWPSDWLKNYHFVELPDENDKGVWTGEIAELSPKDQSDHRRRWEKIGCFDRGVDWFGDGSLWFLDAPGHCPGHIMALCRVSAQPDTYVLLGGDASHHQALYLPVPEDGVDLRSPIPVIDGKPQLAIDPKLATYTIGQMTRMSAEDNVMVILAHEGQVEGIVDLYPGDLSGWMSKGWKEAKERGVEEDATARQNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L2F3</accession>
    <name>A0AAJ8L2F3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Adenine nucleotide transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_102032</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC68111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058595.1">
        <property type="nucleotide sequence ID" value="XM_070202494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L2F3"/>
    <dbReference type="GeneID" id="30175245"/>
    <dbReference type="KEGG" id="kpin:30175245"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF1">
        <property type="entry name" value="MITOCHONDRIAL THIAMINE PYROPHOSPHATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="9"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="165"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="348"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="37"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC68111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="463" mass="51798" checksum="12E0BC54830B9612" modified="2024-07-24" version="1">MAPAPHPPLTPFGSALAGALGSVFANAAVYPLDTVKTRLQAEDDEDEDDEEDDEERDNEVDLPTTNTAKRSSTSDLKKISHLSEFQRYIYSRVKRWGMFMMLLKILKKEGISGAFHGFGASMIGTFSQQFAYFFFHTLLRTSYLRRLSLKTTTSTSKTIINSPSISTSAELFIGALAGAFAQIFTIPVQVIATRQQLWQPSISSSKDKKAVIAPSLFETANEIINENGITGLWTGLKPGLVLTINPAITYGVFERLKSYRLSKRLNGNHNIGKGGKLGVGESFILGMISKTLATVVTYPYIFAKVRLQAKVNPEDDQNEIEDQTLSIESEILDEKNKIDEEDIHLNKNENLTPSYASIASISPPKFGSSIINLPKNQFENLPLNKKQNHKLHHHHKHHKHALSLLKSVYIENGFKGWYKGLTAQIIKAVLCQGILFVSKDQFESYVWILMIFLNNLKKRISSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L368</accession>
    <name>A0AAJ8L368_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Histone H3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_102026</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC68105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058594.1">
        <property type="nucleotide sequence ID" value="XM_070202493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L368"/>
    <dbReference type="SMR" id="A0AAJ8L368"/>
    <dbReference type="GeneID" id="30175251"/>
    <dbReference type="KEGG" id="kpin:30175251"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000001">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="8 9" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="11">
        <location>
            <begin position="46"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC68105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="138" mass="15609" checksum="B0DC4A6314C7A15B" modified="2024-07-24" version="1">MARTKQTARKSTGGKAPRKQLATKAARKQAPSQVSGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAIGALQEASEAYLVSLFEDTNLAAIHAKRVTIQPKDLQLARRLRGERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L3L1</accession>
    <name>A0AAJ8L3L1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Carbonic anhydrase</fullName>
            <ecNumber evidence="2 8">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_103913</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="2 8"/>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC69969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011202.2">
        <property type="nucleotide sequence ID" value="XM_019156244.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L3L1"/>
    <dbReference type="GeneID" id="30172883"/>
    <dbReference type="KEGG" id="kpin:30172883"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071244">
        <property type="term" value="P:cellular response to carbon dioxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00883">
        <property type="entry name" value="beta_CA_cladeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002:SF76">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC69969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="247" mass="27487" checksum="9E9A94A187D8393F" modified="2024-07-24" version="1">MPFHAEPLRPNKEIDLDLEHSIAAQKFPDIKAVLQGNRWWAKEVTQKQPEVWAEQVKGQAPNFLWIGCADSRVPEVTIMARKPGEVFVQRNVANQFQPQDDASQALLNYAIMNVGVNHVIVVGHTGCGGCIAAFDLPKPTEGEQFCDPATPLTRFLDPIIRLKHSLPEGSDVNDLIRENVKLSVKNVVNSPTIQNAWEKSRKGEFRKVYVHGWLYDLSTGLLIDLNISQGPEPIVPDEAKPATNGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L5U3</accession>
    <name>A0AAJ8L5U3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_104675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012718.2">
        <property type="nucleotide sequence ID" value="XM_019153978.2"/>
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    <dbReference type="KEGG" id="kpin:30170582"/>
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        <property type="component" value="Chromosome 6"/>
    </dbReference>
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        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC70724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="303" mass="34035" checksum="E9AB1FF303F5A822" modified="2024-07-24" version="1">MLRKNGSNEYITTQDKVDEMEDIIDNFWNSSISWTEQKGSWIELNFIGNEIWIYGINGPSYSNISFNLDEKDLGNFSQEIDEIDYHHLIFELHNLNNTNRILKLTNLDQGKRMSFDYAIINNSEEIISSSKTKVNSEISTLTNTKELAAQITTSLSISSTSTITNSTITSSANDLNFTTNRNSTSLENSTQTQAQAQAAAAAASSAALAALLPTQYSIKQLSSLKEIYEFKWNSAAYFVIIFSSCVIGIFILFIIHISLKSYIKKNKPSQGYLERDEQHKVEDQSGMRIGNPINVTKNGQVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L624</accession>
    <name>A0AAJ8L624_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_105227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059188.1">
        <property type="nucleotide sequence ID" value="XM_070203087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L624"/>
    <dbReference type="GeneID" id="30172233"/>
    <dbReference type="KEGG" id="kpin:30172233"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="215"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="465"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="770"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC71274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="893" mass="97992" checksum="BA9ACBE479B8F6A0" modified="2024-07-24" version="1">MAPAGLVITKLGIQATATDDVVRGLMCLKISLPKDSEARPGARWALFNSTPPRLLSTPIIHPLPLPVPSSRDPQLRTASKILALPLPSIYPPSSPSGLGGKPYIDISSTTGKVYLVIDPISSRRNSQTRASGSTSQSTSRKEWLICMEFEVPLENGVEEGISKVLLPIPKCLDNTIRFQILSPNIPTSSSSSSSLSSLNQEVNILTDPKMLPLPANAFKSSTSSHRANRHTVRSSKEDKGKGKIKSTVGEDGWEDGEVLGPDDVPSESSQEDTDISDDEGDDSGGGSWLEGRFPSTEVLRLEWSFNSASSSDIPSLQISPRYDKQSSTISIAYVTQIPMTENPISFEIDVPDGWGWSDFTVQGENLMNWRCVDGGWGVSETNLDDSMQEAEYEDSFATVRAKSAFSRKLTPASSTESGHSDILPTIRSTNNATSSSASLMRQTFPSLHEKMEDFSFEMASVEHKPATPTSLRKSPLQMLLSSTSSKGHTSRERPRAGKSFNLYLGAEGDRTIAIQGTLSLIDSMTLVSPSIPMKIPFIRFENQTSQCQVECPWATYGSSKTESSQVELVDIALGGRLAWTGQDGSKFSTSASPLKGDVKVRLRRSPWGIINAFAVFPFPSSREEVGFSIDCYEDIRLLRSTIDGKDVARTMYSENHNQQIRLGKHDQKPGGVVEVEWEMTLGTSGVIGLPVFESTGDGSLKVELSGDEWSSSLPLIKTNMKRDSPNSLTYPLASSIEAKLSLPVPGIVKSRRKTLLSLSNLINLILLWLLLSMGQQLQRLKSEIDFVRDEYKDLRDYGIQLPNQVSEIPITTATVTEVVITTSTQTADQQTSTSHNSDKEKGNLIVVERNKYDLGRVVRGNIHWGDWLTHPTVRTITRGVGWFWNTLWDLVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L690</accession>
    <name>A0AAJ8L690_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BAR-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_104053</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011063.2">
        <property type="nucleotide sequence ID" value="XM_019156105.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L690"/>
    <dbReference type="GeneID" id="30172740"/>
    <dbReference type="KEGG" id="kpin:30172740"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07599">
        <property type="entry name" value="BAR_Rvs167p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000048">
        <property type="entry name" value="BAR adaptor protein RVS167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000100">
        <property type="entry name" value="SH3 domain-containing YSC84-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF1">
        <property type="entry name" value="REDUCED VIABILITY UPON STARVATION PROTEIN 167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="BAR" evidence="5">
        <location>
            <begin position="15"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="363"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="281"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="306"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC70106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="423" mass="47900" checksum="03DC7F56BD75AB27" modified="2024-07-24" version="1">MKGFTKALQRTPHNLTSRIGMTKKSTDPEFNDYERKFSAIETACEKMLKDSTVFRDSVSNLLSSGSSFSASLATLFSPMGAEYNLASKHPQAEVTVKNITVYQGIMEEMRETLLPELELIDSRIVQPCKELNDITKKIRKTITKREHKLVDYDRHNNSLNKLREKKEKSLSDEKNLFKVEQDFEIASGEYEHYNNLLKTELPQFLEMGTRFIDPLFHSFYYMQLNVFYIIQEKLQSFADGKYDLSRKDIESIYYEQRGDTAEQIEEMAIVKRIASTAKMLHAHRSASGTPTRTGSIASRTTSNSYLDRKESYSSSSPKKEVFSPPSRTVAAPPPYTSTNSSSSIGTKKAPPPPPPLKPKPSFNKAVYATAVFDFEAQAEGDLSFRAGDRIEIVEKTDNPDEWWTGRLNGMTGVFPGTYTQVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L8S3</accession>
    <name>A0AAJ8L8S3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_105566</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UTP23/FCF1 family. FCF1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011431.2">
        <property type="nucleotide sequence ID" value="XM_019155277.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L8S3"/>
    <dbReference type="GeneID" id="30171900"/>
    <dbReference type="KEGG" id="kpin:30171900"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09864">
        <property type="entry name" value="PIN_Fcf1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000019">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037503">
        <property type="entry name" value="Fcf1_PIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PIN" evidence="7">
        <location>
            <begin position="51"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC71608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="181" mass="20633" checksum="84C88BB7AED3258B" modified="2024-07-24" version="1">MIKPSDPRLKENVEKAAKKAEKEKAVEEKKAVAQVSSSLFLSHNSDLGPPYRILVDTNFINFSIQNKIELVQGMMDCLMAKCIPTITDCVLAELEKLGPKYRLALRIAKDPRFERLHCDHSGTYADDCLVNRVTVHKCYIVATCDRDLRRRIRKVPGVPLMYVVKRRYQIERLPDGGASFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L930</accession>
    <name>A0AAJ8L930_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_106381</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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        </subcellularLocation>
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        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
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        <source>
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    </evidence>
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        </source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="315" mass="35399" checksum="ED057D407FEC298B" modified="2024-07-24" version="1">MTSTSAQPACLRCRSRKTKCLGRTESTDCQSCMDVGIKCEVIPHQRGRKVGTRLSDSVRARLKRKRHKEAEERKAKRQITLISNDDHRQQVRVNGSSNNHIDPSISSTYPTTSTNRSQDPSSSYSVSRHTIRPTSSARVTSHQANPGLASVDARHTDYSDIGPSVRRTSSIARIFSDVDKDKERNSNSNSALSLWREDPITCGYINDDTAKDLFNLFMSKIAPNVYIFDQALHTYDYVQKTSSFLFCVILATAAKFSSNINGYTHKKCLALAKDQILRVFADDIKSEQTIQALFVLTEYKEAEDENAFLLLGMAW</sequence>
</entry>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Imamovic A."/>
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                <person name="Shea T."/>
                <person name="Sykes S."/>
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                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">CBS 10737</strain>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="David-Palma M."/>
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                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
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                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        </source>
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    </evidence>
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</entry>
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    <accession>A0AAJ8LAR1</accession>
    <name>A0AAJ8LAR1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family-domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
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                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
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                <person name="Howarth C."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
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                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="WWC72212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042464977" description="Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family-domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC72212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="21041" checksum="2E8095D38B828945" modified="2024-07-24" version="1">MFAKLTITALLLAASAQAAISILYPNSEAIWYKNNTVQMNWTLTMPETDIYFFRTYLSNEDQSILAGNHSIADSTSATAQDVRILLPQIPSGKGYIVNLVNTTNENQIFATSNPFEIADGIVTTSSTSGSSTSSSSSATSVNNIPNAITTSQIPFPSSSVFPSSSSTSSAKSLFDNTLHALLAQGVAIILVAFGTLVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LAT7</accession>
    <name>A0AAJ8LAT7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_106729</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
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            <taxon>Tremellales</taxon>
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        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the complex I NDUFS4 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007749.2">
        <property type="nucleotide sequence ID" value="XM_019159077.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LAT7"/>
    <dbReference type="GeneID" id="30175752"/>
    <dbReference type="KEGG" id="kpin:30175752"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.190:FF:000001">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 21 kDa subunit mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.190">
        <property type="entry name" value="atu1810 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006885">
        <property type="entry name" value="NADH_UbQ_FeS_4_mit-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038532">
        <property type="entry name" value="NDUFS4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219:SF8">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04800">
        <property type="entry name" value="NDUS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC72765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="177" mass="19775" checksum="D6AE66BC1610063A" modified="2024-07-24" version="1">MSASRSLLRTSTRSFAGIRALHTSRAAFNKPDAFATPVPTAQPGQNAPAEFQFPGLPQVETVSGAPSEMLQRHVRIYRPTKSTMQSAKGKTKRWMLDWDVLQGAGRWENPLMGWAASADYVQGTSLIFPSKESAVRYAEKQGWPYKIDEPKKVIVPPKNYANNYVHVPGKLRIHHTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LB83</accession>
    <name>A0AAJ8LB83_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_106407</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008043.2">
        <property type="nucleotide sequence ID" value="XM_019158905.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LB83"/>
    <dbReference type="GeneID" id="30175580"/>
    <dbReference type="KEGG" id="kpin:30175580"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000003">
        <property type="entry name" value="Calmodulin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="3"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="75"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC72445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="142" mass="15754" checksum="8B09D146167F3F22" modified="2024-07-24" version="1">MSGNNAEYREAFALFDKKGTGQVPKESLGELLRSLGQNPTQAEVQQLEQNIGSNSFSYDQFLNVLNRPDGWKPAGTADEFIKGFQVFDKSGNGFIGAGELRYVLTQLGEKMSDEEVDELLKGFPVQDGQINYHSFVRSILAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LCI5</accession>
    <name>A0AAJ8LCI5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA-dihydrouridine synthase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_107665</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059670.1">
        <property type="nucleotide sequence ID" value="XM_070203569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LCI5"/>
    <dbReference type="GeneID" id="30174370"/>
    <dbReference type="KEGG" id="kpin:30174370"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048337">
        <property type="entry name" value="FAM50A/XAP5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007005">
        <property type="entry name" value="XAP5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12722:SF0">
        <property type="entry name" value="PROTEIN FAM50A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12722">
        <property type="entry name" value="XAP-5 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04921">
        <property type="entry name" value="XAP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM50A/XAP5 C-terminal" evidence="3">
        <location>
            <begin position="183"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="DUS-like FMN-binding" evidence="2">
        <location>
            <begin position="447"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="DUS-like FMN-binding" evidence="2">
        <location>
            <begin position="527"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <begin position="68"/>
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            <begin position="70"/>
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            <begin position="97"/>
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    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04921"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC73693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="745" mass="84130" checksum="BF4D5029CDE789B5" modified="2024-07-24" version="1">MSGPPEEARRNLMLAKQREREAAEHQRQKDALIKEGEKDHTVDRFIGVTENLDERLIKTTVGLVTLSDFQKTKDDLEERQRQLAAQVAADKGAKSVTKPKKTKKKEKSKLSFADAEEEEGDTGEKRPREDAVDENGERKKKFSKNPAVDTSFLPDRHREERELIEREELRKKWLAQQETIKGETIEITYSYWDGSGHRKSVECMKGDDIGTFLNKCRQQFPELRGTSVENLMYIKEDLIIPHHYTFYDFIINKARGKSGPLFNFDVHDDVRLLADATVEKDESHAGKVVERSWYNRYKHIFPASRWEVYDPDKEYGSYGQHPLLNSTGYHMVLSGFRNSKIALLERLFAFRPLTMPVAIARSPSPNQNIRDAKRHKAQHAPVVSEEDMINAAEGSIRSAAIAKNDLVTVQDIPNRTEAELIEEQMAMPIEYPKTYENELNYREKLVLAPMVRTGTLPMRLLSLYYGAGLVWSPEVVDKAIIGAERTVDLIFQIGSSNPELAVKAAQTVQQDVSGIDLNCGCPKSFSTGIRNLTVHCRTRDMRPGERALWERLADIVALGKKRGLPVICNGDGDGWSNWEKIRTETNADSVMIARAAERNPSVFLPTGPVCNMTEVIPKLLAIAKHTQNPWGNTKFLLTQFKPSPAPISNMSKQERKNAAEIVSKSKSIEQVAEGFSIPLDGTESIFKAVIEKIGERPQTDTNIWEERHKAEENGVIVEHYFPVESEAQVDGFDVGIGQATSSSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MMD2</accession>
    <name>A0AAJ8MMD2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF2264 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_100299</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
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            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="654" mass="72853" checksum="F7BDE83B0562DB71" modified="2024-07-24" version="1">MLLGTNDFLNNPYLNREDVLKGCIALLDPLASHTSRGGALLDIGSTATHYDVKAVALEAFARPLWGLASLLAGGDKYEGAERWVRGFDSGTNPKGDEYWGESMDKDQRMVEMSPLSFAVAMAPEVFYNNQSPEAKKNICAFLQSCIGKKMPDTNWLWFRVFANLALRAVGSDFHNPDQMEKDLLRLEEFQLPPHDTEGDDAASAGWSRDGPEDVRQLDYYSSSFAIQPAQMIYAKLAAKTDPERAEKYRQRARDFLADFVYYFSDEGAAIPFGRSMVYRFAVIATASTMALADIEPAAPLTWGHVKGLVLRHLRYWNDAKDIFRSDSTLNIGYRFDNMNMTENYNAPGSPYWCMKAFICLAAPASHPFWTSEELPWPKDILPLTKSLPDPSHIMCRQADHTFFLSSGQVPHYAMRHGPAKYCKFSYSSAFGFCCPTGDMDLGQLAPDSMLALKDASDGVDSSDGETWRVRRNPIDAKIIGRGTDKVHLRSKWRPWKDVEVETWLLPPPNAQSSYYLRIHKISSDRRLESSEAGWTNYGQGEDGRALIQSFSGLMSKGGDQEIGWSRAVTAGGAVGVVDVSYKGSSGKRQGQLVQIDPNANVIFSRGILPSLKGIIEPGESWLVTAVFGKPSKEGKTQGWEECWKQVPQVPSWIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MMY8</accession>
    <name>A0AAJ8MMY8_9TREE</name>
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        <recommendedName>
            <fullName evidence="6">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">I206_101458</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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            <taxon>Cryptococcaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
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            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="WWC67549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="30174939"/>
    <dbReference type="KEGG" id="kpin:30174939"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
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        <property type="entry name" value="PH_domain"/>
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        <property type="entry name" value="Sec7_dom_sf"/>
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    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF373">
        <property type="entry name" value="PH AND SEC7 DOMAIN-CONTAINING PROTEIN C11E3.11C"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="778"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="1209"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="794"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <begin position="1015"/>
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        <location>
            <begin position="1511"/>
            <end position="1539"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
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            <begin position="306"/>
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        </location>
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        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="1516"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC67549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1539" mass="167541" checksum="0E59089E37149813" modified="2024-07-24" version="1">MKSPSLSSSSRSPNPPLSARAPSPNLPNRPSTSSNRSFKRSEADFEAALLDPKSTIFLSASPNNSPIIENDEVKSKNLKSSPFLGIAVDSNAPLPIEKHSFEEDLNNLKYDDESGKKGLGILMESPLTPDKNGSIGIIPPTPSTIGNKNGRHNRRSSQMTTDSGYQSSNYSDTTNGTPGRRKVSQSLGIDAELGEKTISKSHQMPPKRRSIFRSPGTASSPDLATLVRKAKEAKSSPQPPMANTSRNDAAQKQYQDPPASAGPSTTTIPINSGRPGTSGSIRYSSNDNTGSPNHSHAESSATASARNRERSRTNSRVDDEHLERYGNMLGGNQMASIAEGSGTIGSSARSRQQSDEGFKSMRTKARGVFGKMFGSSKDHHLPPITPPSATSSRFPVQSSSQPPVPPVPSAYASNRRKAPSPPDESVEVFRTNDHMRSQSTRSVSASTIPARQGSPHAGYDGRTSVTPTDRRVSGYSDLSVDKPLPAVVEPENAPQRTPSNTLRVSGHTRQPASTAEEDSPHSMESPLKPSASPGTRAVHTFKSDMAGMLEDIGQTDPAKELGLPPDSMRRERNRTTSNETARHETSRSRYPSELGTSPSMRDHSHHHKTHLSPVPNQRTSSLPFSSPQLDQPIPKRTTSSPSPNPSLNGDSASGLLPNQAVVSRASSKSSGKKSDHQGSPSHPTVPSPNRSPSLSRGIKKPFDELASVTGSGSQQGSPLMPSSVRLVSSPNEQEQGKLAAALPLDLLQTSGLEKMSSFRNMSPWGKQPTRMMSAPNAHDNPHLGLNRDDQVEVVDTPSETPKTAHEEDEEEKGRRLACEFLEDDFTNVSGEKVAEFLGGPRPINSIALKYYMQYFDMKGQTLVDSFRDLCQKLHLKAESQEIDRIIEAFSARYFDCNPSTVYGTPGVVHTVTAAMLMLNTDLHIAELNKHMSRTDFVRNAMRAIQESMPSAERERDGDSTPDLTRGDSSSMKAGFGSNGSMAPSFVSVRAKPSITANAPPTQRSASAPVVTIQHQHGPIRTESTSSIGTNGIADGKRGGSSTTVSSFTYNKAWEMEAENALREIFASVKAERILLPISGTGQGTTQSSRQSMISISSNGPFDRARNVRSPSDRVNALKRGSIRGVQGLLNNPYGSQWSASDGRLSPTPSYATSINEGLGSFAPTLGFASNLSHTVIREHDDEVRSMDSNTSVDTAEDMDDDELALLGAPWAKEGLLSRKLYWESINKRAKKNDWKQFFVVISKGELYMFTFGEKGSGNMGFTMGGSVGGGNWLENANANGQISLMHTMSVALPKPGYNANRPYCFSLAIPTGETSFFQAGTEDLVQEWVSTCNYWAARKSRQPLKGGVSNMEYGWNRVIIDSNGNDENEDDKISLRSNKSNLSRLNINSSTGGTYGRKSIIMNGNDKIFINDWKSPPPATMPSPLDEENQLEALQNYIKDLVEELENHKAIEEPMNKLYTPGSKNFLKAKENWKSKSHYIHTEIFKYETYVEALRNAISLRVKKQGEKKLEKSLARSMTSLHRQISNNQNGKEEEEEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MNE5</accession>
    <name>A0AAJ8MNE5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_103844</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC69901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058939.1">
        <property type="nucleotide sequence ID" value="XM_070202838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MNE5"/>
    <dbReference type="GeneID" id="30176166"/>
    <dbReference type="KEGG" id="kpin:30176166"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF5">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="5">
        <location>
            <begin position="174"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="357"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="597"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="689"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="905"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1001"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="392"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="609"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="621"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="715"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="726"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="907"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1005"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1035"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1051"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1072"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC69901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1107" mass="122785" checksum="322DD1F84BDBEFC4" modified="2024-07-24" version="1">MPDLLTPQALATAGPLVLETLFKHFIGPRPSADKGKAREDLMYDEAFVIMKTFLEIATKHPVAALQRFGQVRTPSPPWVGVHRVTIPRTSLNDAAKYMIDGFGGEEMAYKIAGGTKWWQVRAGLGVEGEWIVMKKDWKGVVAEEKREKERRENEGEEEGDEGEFRPEMDRLRCMLYIHGGAYYWGSINTHRYTIWRYARKMHGRCFAVNYRKTPQYPFPCALQDCLAAYIYLTNPPPGSQHRPVDPKSIILAGDSAGGGLCLALLQILRDTPGLDLPAGAVLISPWSDLTHSFPSILQNTATDIVPPYGFIHKPSSLWPPPPPPLTQEVQSNLKSRVKEVVSRFHHHPHRAEEIHEALSKASLEEEDISTIGKPTTIPDKLKTSDPAGGLAKSKDKSESDLHPMADKSENKHPEPHGEPSGNPSRANPALLFSKLATKSEEIKDSETATRARTLAQCDIPLKLTVKEEEILIDTQIQLYATNAQLCHPWVSPVLGYLGGLPPLFVMCGDKEVLRDEIIFLAHKAANPDGYPIRDDVKALLPSLHGIEEKHGATNVHLQVYDGVCHDLPLLSMTRPSRGAFRAIASFARYVTPSAPGSRYISRSYPATPKDSEDSTPHESMSRGSSHGGLQSLSTTDEVGVPSTPIDTEQRIVDNTLTATPAVLSPEQSIDLKRRPPTLDLALGDELHRADSPRSIEEAPSVSIVSTPKPEESKHTLNIKTPTRNVSFASSFDSSMGSERERERKASILPPSPNPQNGSGSEMPKEGRRGNSQPSGDDSGPRFEVEEQYANDWKAKQGEAGWAGIYNGDDPFTAHMIRERVSTIGELRPLEPPEKLQAIQMPLDEVGFIKEGPALRYINGQALWDKKYHRAAKGVKRRREKNLKIAQREGGKIGNHWLEKVEKRIGNESGGITSGGGNTPASSSKEKQDPIDWSESWTWALNGESPPPSAIVSRRDFGEARQLALMADRLDSTHSTVIHGLSIWVGLASFFSNSNERNKASQAVKAAREVKKLEKGNKNNNNNKKKNKKDDRDIWTDLDDEDENENEGSNNQINENRTQNQSGINKYIDLIEKTSTTTKTQGKSTKGQKGYKRKGPITRWFDNFKKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MQE9</accession>
    <name>A0AAJ8MQE9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar protein sorting-associated protein 45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_103550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058889.1">
        <property type="nucleotide sequence ID" value="XM_070202788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MQE9"/>
    <dbReference type="GeneID" id="30169815"/>
    <dbReference type="KEGG" id="kpin:30169815"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="598"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="599"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC69607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="703" mass="77078" checksum="2DBA59AF226A3475" modified="2024-07-24" version="1">MDVLKAVQTYINKMITEVPGMKVLLLDAHTTPIVSMVTTQSELLAHEVYLTDRIDNINREPLNHLSCIAFLSPSESSIQAVKAELTKPRYGGYWLYFSNTLTKNQIEEMASVDEFEVVKEVQEYFADYLAQYPSHFSLTQAALAEGGDGPSNPPIFLPPPLHLPPPTLASHLQAILSVLLSLKKRPVIRYERMSSAGKKLAMEVQASINNPPYRELFDFRSTQGAAPLLLVLDRRNDPVTPLLSQWTYQAMVHELLGINNGRVRIEGEEKIELRDLVLSTSSDPFFSQNLFANFGDLGASISQYVTEYQQRNSSLNPGSKDKGSANRIETVADMKKFIEEYPEFKKLSGNVTKHVTLVGELSKIVERDGLLEISEVEQSLASVESHASDLRSVQTLISSPKTRSTNKLRLAILYALRYQKLIGNQIPQVIDNLISNGVSADKARLVYIMLNFAGADIRQDDLFMNENFFSRGKSALKGLKGVENVYTRHEPHLTQTLDLLLKGRLRDNSYPFVDGDEAARTQKPQDIIIFMIGGTTYEEGRAVALLNQKLQNEASGGPGGTRILLGGSMVHNSSSFLDMVENCALNYPDSIYAPPLGQPTSSLLSSSNTPIPSSSSTPIPSSGGGPSINLRAGGYELSVGGVAGSGIYRTNQDSGANAQFELPKMDTVAGVAGGIRDGAGKLWGNVRQKVEERVSRGPTPQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MQL4</accession>
    <name>A0AAJ8MQL4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_104788</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059100.1">
        <property type="nucleotide sequence ID" value="XM_070202999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MQL4"/>
    <dbReference type="GeneID" id="30170696"/>
    <dbReference type="KEGG" id="kpin:30170696"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="186"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC70836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="367" mass="41802" checksum="E6DC790D17D75D6D" modified="2024-07-24" version="1">MSVIDITGMPVEQVEAIAKMAFGDDVGWHIGPFLLSVIFDGILLGVISQQYMTWWTYSRLTERKINVYVTHFLVTAAVAYTACEISYALHNFVYNFGKFRVFLEIRYPQVFPILGWITSAPIQLFYTERTFRLNGNNWLLCILLMGLILGTFGMTVWVLVFCQTLSSELQALLIVRQVQAWQCLTLATDSIITISIAWGLYRSRTGWSKTDALVKRLMIITLETQLGPTILMLAFVIEFAISPPTTLGIFFEQLIPKFYLVGFLATLNSRYNLRRDSQPELNAQCSPKTETRLNTYLLGSGQMQQATVNIETGTYFETHHMQKSQIGLNRLPLQDNSQSGNQEDLDEKFIWSNTQSTHSLHDVAELM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MR45</accession>
    <name>A0AAJ8MR45_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I206_105346</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059205.1">
        <property type="nucleotide sequence ID" value="XM_070203104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MR45"/>
    <dbReference type="GeneID" id="30172113"/>
    <dbReference type="KEGG" id="kpin:30172113"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10509">
        <property type="entry name" value="Zn-ribbon_RPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034014">
        <property type="entry name" value="Zn_ribbon_RPC11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF12">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="12">
        <location>
            <begin position="66"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="10">
        <location>
            <begin position="4"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="4"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC71391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="108" mass="12743" checksum="BA5E9F7A195D1AFC" modified="2024-07-24" version="1">MLFCPYCANNLTIGDREDSSDKCWICPTCPYQYIIDRQISMRTHLKRKEVDDVLGGKEAWANVDKIDTACPKCDFRKAYFRQLQIRSADEPMTTFYKCCECAHQWREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MRI9</accession>
    <name>A0AAJ8MRI9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phorbol-ester/DAG-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_104986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC71033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059146.1">
        <property type="nucleotide sequence ID" value="XM_070203045.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30170894"/>
    <dbReference type="KEGG" id="kpin:30170894"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00029">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1076"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1081"/>
            <end position="1095"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC71033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2345" mass="258120" checksum="74F113F977E80A9F" modified="2024-07-24" version="1">MDARRDSRLEGNKDARKALGVRPGGQPPPRLHIERPSVPSAPPSPTLRAPSSPKSPPGSRNVSIAIPPIAIPPSPTSDQPKRFRRPTISSKNKPLRITSNRGLYETQKLLSHLLDKIEARDAAPDLLERAAISAKEISGKGKSKSKGKVKRLGHAIAAAAQHATIPSTPGSSSLLSPPSSAALGAGLGSEDFEDIYLVEGEMDTEAIYNLVEQTRGLLVLAEKQGLDLFHDEGGRGSLAGVPILDSTPVKNKRKTGRFSSIAPVNSIKPSFSFQHGQSEKQEEEEVKPRQSTSISISGSALLSRILGILHTLLTVDCIHRTHLFRPFCPPYALQAACLDIANYIYMKSDTETKIKVVGMVVDGLYGMGLMVERVCQWLEGKMGELLNRLARDRGGPKKGTETVENMSWTDPFSTKEAPGKAVPTFAISTDSQDSLPPPPAANTPGWLRFSPTSPSFPFFPAGDVAGLLSTHAAKEVTTTTIQIASLVPRILLGITTIVDLSISKLTTIHRIHRLLALILTAKPDSALDLLEIIAYAPPVPRRTALEILSTFYPMVLGHNTISRRLANTTYAAQRAKWESGQEKALGEDDVVHYFIPWRCSSKDDPSNQVNKCDICDGEIHGFALKCSMCKEYRHLHCYHTSVQTYDVITITSEDSAHQMVHIKYSPIPPRLDEQVLFGSTAKGNSSSTRRRVGQHDLILVNLFNLALCEECHLPLWGDMSQAYGCMNGCQRFFHPKCLDHMERHGRGQCRFGRDVIIDEISSQGSDPFLISLERFKQSFDTIFKQLCLNVDELARKTYDEIAVLWGGLWIQYQLLKNGISSGSIRITGYNPKIEPDLLNVKSTLKVYEEQLKARYTEASPASSDFTHISGSEIPLGCSYLFSDRYLTYVIALLRAPTSNNPLASGTQTPSDGLLTPSGLPAPDDIQPNEESFEMLPLSIISSSLSSDLGISDPTISTIFLNQLRSIGLITTNNKSFISQEDLNSPNIWAGFNLPLLMDNSTTINLLILSIENLLDTLDLSMNEQGLRLLSERCWPSLLCSSYSLDRLGKILINWIMNEDDCLLGIVRSYASKHKKLPGIRSTPSSSNANSSSKLNINTNQNQNSVNIYKESRLKVMNKFGKPWLKALHDLDPISYAAMVYEECKNPLAAGKLNFETDESDDQMASKMAGIALERMSSVVDADVIFSTLMELVTAWLEDLGALADQDVVYRSLPRLLRHSSSIPSSSFEQPDLFSLSLSVSQTGPEGLIRVCRWLRVLSFSGVDVPWELLMDLVELQSTTRNEIDARLDLVIAIGANSTSLNPEAFAGLCAKMSNGIFQDIAESKGSGHPLTPNELDLIRQFMLLCLRAYGVPIEEVSQTAFSNGDLQTKQPASMSKKRRAVSGRANLSLEKEMILSAATMLDCTDVPCELILDFLWLLFTRAMMVDKVDGFINRACSRLYQLIWPLVDLSTVDRRSRTRILLKMLSVNSNALEKIVREQLDSGSGGRAQVRERLLTFILDLADSSILFEVTAWESSAVGLILLLFDVLTDTSEMISDNLVILHALLPTHLQAMSECFEDYLLRHNDEKRLVLLTRLRKLRLNLPIWPIISWTKIEELLAEQVASIAQTRPSRTSQTVSALTDSQSVRCSLISLGLDMLSAGVPIPWIIAQRFQQHVASCLALPWTNPVESLTSLVLPSLRGVLDSSVRITISGQTFESKAKKTASVGTLFVPIIIDLGGELGKFEYLTQRVLLDILMVTFFKQNVRTVELAALSSLQTLAQFVATSECAENRLLALQILQIAPVRMDRESVIRAVPSVFATIAGVLVKENEAEHADSAVIEQSRVFLRDIIKSFGRSGLFVQLFRIDDTATTSPKEISTLGKALQLLHASEKSIDGRPTMFDNAFNNLSDVLKRGRQTIEQVLASLCRFAESLHVELSEEVAQSIGLFLARLGKHVAEWDSQEFDPNPALRTCAAVLDLVQPAASITLLHQTSTFLHLTLARFSVSQETLSKLLDISERIARGQSTEDTVRTVTFELAGSIVHGLNVTPTTLLTLLNFLAISAFPERALDSRSFTQQKRVLADSAPGCIQILLRTHPTFTIGNMEPDVTLAIMLKTATVLCRAEMIVEGIISQSLANITNEAASTQVNLLIFILLSSLDLQMGPARKRIISLYPLLSRATSLCLRASADLLTLQDMSGDGAELLSVVFAVFRLALLALRDQTNTGDRIRGNIEEDTMDGFWCRIWPDWYRLITISLDSTCVNGPLKAVSHSVFLDIIIFLGITHSTILSKHSGTLSHALTVLVKYQESIGTGNTSGKLQKAAQVLDKISIGIGIGNLGENDRLGIINTIRKDLSATERLKALRNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MSI6</accession>
    <name>A0AAJ8MSI6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_106810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC72846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059508.1">
        <property type="nucleotide sequence ID" value="XM_070203407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MSI6"/>
    <dbReference type="GeneID" id="96955776"/>
    <dbReference type="KEGG" id="kpin:96955776"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WWC72846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="67" mass="7051" checksum="8F80F4E9CA6AC7F4" modified="2024-07-24" version="1">MGMSTTPKTILVTGATGPQGGALIDTSLSEPNIESAFRILALAWDPHTLCAERLLSKSTPSDCPHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MSX2</accession>
    <name>A0AAJ8MSX2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Anaphase-promoting complex subunit 4-like WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_106688</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059483.1">
        <property type="nucleotide sequence ID" value="XM_070203382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MSX2"/>
    <dbReference type="GeneID" id="30175792"/>
    <dbReference type="KEGG" id="kpin:30175792"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="16"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="4">
        <location>
            <begin position="26"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="60"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="101"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="250"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC72724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="367" mass="40025" checksum="94B6BF1309CD3F9D" modified="2024-07-24" version="1">MLSSAFRAPAKDIELTSPPPDSVSALAFSPTADILAVASWDNNVRLYDVNSQGQSQGKAMYSHQAPILDLAWSKDGQFLFSAGCDNTAQMYNIQTQQAQQVAQHDAPIKCIEYAEVPGSGPVLITAGWDKKLKYWDLRSPNPIATLDLSDRAYSMDVAQSLLVVATGDRQIHVVNLSSPTTIFKSIESPLKWQTRVVKCFPTGDAYAIGSVEGRVAIQYPGGDEKKNYSFKCHRYDIPTGTMPGTPSVSGSQHVFAINTITFHKTQYTFCTGGSDGSLTFWDGVARTKLKTFSCKDLSNGDTDARPPQFGTPIVATSFNHTHEIIAYAFSYDWSKGHGGVPPAGSNITKVMLHPVKPEEVNKKPPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MT27</accession>
    <name>A0AAJ8MT27_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Chorismate mutase</fullName>
            <ecNumber evidence="4 13">5.4.99.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I206_106632</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>chorismate = prephenate</text>
            <dbReference type="Rhea" id="RHEA:13897"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="5.4.99.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:13898"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; prephenate biosynthesis; prephenate from chorismate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="5.4.99.5" evidence="4 13"/>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059460.1">
        <property type="nucleotide sequence ID" value="XM_070203359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MT27"/>
    <dbReference type="GeneID" id="30175846"/>
    <dbReference type="KEGG" id="kpin:30175846"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.590.10:FF:000002">
        <property type="entry name" value="Chorismate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.590.10">
        <property type="entry name" value="Chorismate mutase, AroQ class superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008238">
        <property type="entry name" value="Chorismate_mutase_AroQ_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037039">
        <property type="entry name" value="CM_AroQ_sf_eucaryotic"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01802">
        <property type="entry name" value="CM_pl-yst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21145">
        <property type="entry name" value="CHORISMATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21145:SF12">
        <property type="entry name" value="CHORISMATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017318">
        <property type="entry name" value="Chor_mut_AroQ_eu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="Chorismate mutase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51169">
        <property type="entry name" value="CHORISMATE_MUT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0827">Tyrosine biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR017318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WWC72668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="296" mass="33356" checksum="8424A4C2BDB8B489" modified="2024-07-24" version="1">MNFTSGAAVSELLSLDHIRNQLIRLEDTIIFLLIERAQFAYNKKIYQPGAFQDELNFSGSWLEWFLFEIESFHAKARRYTSPDEHAFTPLDKLPQPIIKPQSLPSLLHQPAAKHPSVNVNHRILDFYIQQIVPGITSTTRIAKGKAVLEDDGNYGSAATRDVEVLQALSRRIHFGMFVSESKFLEAPHDFIPHILNPNPEALAGLITKPAVEAKLLIRLANKARVYGGEMDADGKVVEVADEEMAARGKIDLATIVSMYKDWVIPLTKDVEVDYLLHRLDDVPQSQIEVWMKGKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MU03</accession>
    <name>A0AAJ8MU03_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Spermatogenesis-associated protein 20-like TRX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_107324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC73357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059596.1">
        <property type="nucleotide sequence ID" value="XM_070203495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MU03"/>
    <dbReference type="GeneID" id="30173501"/>
    <dbReference type="KEGG" id="kpin:30173501"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02955">
        <property type="entry name" value="SSP411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024705">
        <property type="entry name" value="Ssp411"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004879">
        <property type="entry name" value="Ssp411-like_TRX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899:SF1">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03190">
        <property type="entry name" value="Thioredox_DsbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006402">
        <property type="entry name" value="UCP006402_thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spermatogenesis-associated protein 20-like TRX" evidence="1">
        <location>
            <begin position="12"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC73357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="748" mass="83961" checksum="790F5A90914D1276" modified="2024-07-24" version="1">MSSSTSIPELTNVLGKSKSPYLLQHKDNPVAWQEFTPSTIQIAKKLDKPIFLSSGYSACHWCHVLAHESFEDEEVAETMNKYFVNIKVDREERPDVDRVYMTYLQATSGGGGWPMSIFMTPNLEPFFAGTYFPKVRFKSLLMRIAELWEEDKEQCLAMGKGAIESMKDMSGSSARIPGTLDEILSTCPSTKIYSQLLKLCDTRYGGFTQGGSRSSGPKFPSCSMTLEPLARLASYSISDQVDNEKAREMAIKMIRGIWKGGIHDWIGGGVARYSVDAKWIVPHFEKMLYDQAQLVIGALDFALLSNPSEAEDNTHRERLQEDRELCFDLAADILKYTLRDLKSPDGGFWSAEDADSPPSKGAKKSEGAFYIWDARELDEVLAEDSDLVKEFFGVKDDGNVELQHDMHGEMKGKNILYQAKGYDEVARQFGRTADDVRDVVKNSIVRLKARRDQRERPGLDDKILTSWNGLMLSTLSQAASTLPETYPIKSKCLPAAEAIVSFIKDRMWDESKRELARSWREGKGPIGQTDDYAFLIRGLLDLYESSGKEEYALWAIELQEHQDELFWDETGDGYFASASDEHVLVRMKDAQDAAEPSATSVTLHNLSRLSLIHSNEYEKYEKKAEDTYLSIGEELKQMPRAFGYSACGLMDIEKGYREVIIIGSPSDNKTTQLLQVIRSTYSPNQVIIQIDPSNPPYGLGKLNDVVKSLVDNIEAGKEDEVSLRICENGSCGLPVKDLEEAKKLLGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HTE4</accession>
    <name>A0A1B9HTE4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cyclin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_07390</name>
        <name evidence="10" type="ORF">I206_106721</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the cyclin family.</text>
    </comment>
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        <property type="protein sequence ID" value="OCF46537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="WWC72757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_019159084.1"/>
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    <dbReference type="STRING" id="1296096.A0A1B9HTE4"/>
    <dbReference type="GeneID" id="30175759"/>
    <dbReference type="KEGG" id="kpin:30175759"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
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        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:cell cycle G1/S phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="CYCLIN_CCNO-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20559">
        <property type="entry name" value="CYCLIN_ScCLN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000010">
        <property type="entry name" value="G1/S-specific cyclin Cln1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
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    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
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    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0195">Cyclin</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="106"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="8">
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            <begin position="201"/>
            <end position="312"/>
        </location>
    </feature>
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            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <end position="381"/>
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    </feature>
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            <end position="38"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="359"/>
            <end position="369"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCF46537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC72757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="465" mass="51472" checksum="4993444A66385F11" modified="2016-11-02" version="1">MPPTAAVKSARSSIYGWTKKRSVSPSSSQQSTSSSKPKMAQQPQHHYSQPAAPTPRRPEESPYFEEDYSDEIVAYMHSMDNATLASAELMDMQPELQWFMRPYLIDFLIEVHQQFRLRPEVLYLAMNIVDRYVSKRVVYKKHYQLVGCAALWIAAKFEDGKDKVPLVRELAEMCCKAYDESAFIQMEGHVLSTIGWTIGHPSAEAWLRIKTTGHSYEDPKVQNMARFLMEITLFHREFVGIQSSLVASGALMLARFICGKARKPVARHENVAVRIALAIDKHFAEKLENVSEIVIRKYAPTYYGRCSTICREWYLSGRRFVYNPEAPATPISTNLPTPGLAPSGSGGWPSKRGSWATGSPSGSISCASSEAGDDAPLTPITPVHSHVMDPFSVASKENIAPAVYGSNPSASISKDSVSSVSVNVTTSKPLPQAPVYSHAQRPPLHALPAVGELSLPNRSMRRLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HTH8</accession>
    <name>A0A1B9HTH8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_07426</name>
        <name evidence="4" type="ORF">I206_106685</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894016">
        <property type="protein sequence ID" value="OCF46573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007792.1">
        <property type="nucleotide sequence ID" value="XM_019159120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HTH8"/>
    <dbReference type="STRING" id="1296096.A0A1B9HTH8"/>
    <dbReference type="GeneID" id="30175795"/>
    <dbReference type="KEGG" id="kpin:30175795"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628135" evidence="2">
        <location>
            <begin position="21"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF46573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC72721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="295" mass="27275" checksum="705D5C2023CB2B3B" modified="2016-11-02" version="1">MRFTLAFSIITLLASTSVLAAPVPNTEGPATTEVAAVPTSSAPAVPATTSSTPTEECSEDCESPAAGTTENAAMATTSPEAAPSSGGSSGDTGDMGGTPIPSSEAPAAPAPAPSSESPESPAAPAPSSESPSPESPSSESPSPSTPSSGCEGEGCESTPSTPSSGTELPCDEFGNIIGGGGKSSSPIGGGGSSPSGTGGFGADCDEFGNPIGGGVSSSSPVGGSGSSPKGSGGSSPGESSGSFPSGSGGSSPSGSGGKGGEDCDEGTGSTGSSGSSAPGEGSTPGKREVDNEVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HTK0</accession>
    <name>A0A1B9HTK0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">Pyruvate kinase</fullName>
            <ecNumber evidence="6 16">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">I206_07448</name>
        <name evidence="21" type="ORF">I206_106661</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="21" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="6 16"/>
    <dbReference type="EMBL" id="KI894016">
        <property type="protein sequence ID" value="OCF46595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007814.1">
        <property type="nucleotide sequence ID" value="XM_019159142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HTK0"/>
    <dbReference type="STRING" id="1296096.A0A1B9HTK0"/>
    <dbReference type="GeneID" id="30175817"/>
    <dbReference type="KEGG" id="kpin:30175817"/>
    <dbReference type="OrthoDB" id="108365at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00288">
        <property type="entry name" value="Pyruvate_Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.33.10:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.20:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004491">
        <property type="entry name" value="PRK05826.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004978">
        <property type="entry name" value="PRK06354.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13 16" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 16 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 20" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="18">
        <location>
            <begin position="83"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate kinase C-terminal" evidence="19">
        <location>
            <begin position="444"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OCF46595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="WWC72697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="583" mass="63552" checksum="9D9D1F1705B6ACA7" modified="2016-11-02" version="1">MSYALGHVPPSRPLTPSPSQNQSYRLPLDSRAQLRQRQFSIGGPLSIMSTSPYSNNTPTSQLAWQASFSTNFNEMTPEEKFFRKTSIIATIGPKTNNVDTLVALADAGMNIVRMNFSHGSYEYHQSVIDNARAAAAKSPNGRPLAIALDTKGPEIRTGLMKDDADVPIDAGHEFWITTDKSFAESGTKEQIYMDYTNLPKVTAPGKVIYVDDGVLSLQVISIDGEKIRVKSLNSGNLSSRKGVNLPKTAVDLPPLSEKDKADLAFGVKNGVDMVFASFIRSGNDVKEIRKVLGTEGANIKIIVKIENEQGVTNFDEILRETDGVMVARGDLGIEIPASQVFVAQKMMIAKCNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAVMDGADCVMLSGETAKGKYPIEAVKMMAETAYLAERSIAYPHLFDQLRSLTPRPTETAETLALSAVAAAMEQDAGAIIVLSTSGVSARLLSKYRPECPIICVTRNQQTARQLHLSRGVYPVWYPEPRGIPGDKWQIDVDNRIRYGLRVALQLSIVKPEATVMAVQGWKGGLGHTNTLRILSVPADPADLDLHSIERDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HTR9</accession>
    <name>A0A1B9HTR9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chaperone regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_07510</name>
        <name evidence="4" type="ORF">I206_106599</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
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    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
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            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
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        </source>
    </evidence>
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        <source>
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        <source>
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        <source>
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    </evidence>
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<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HU18</accession>
    <name>A0A1B9HU18_9TREE</name>
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            <fullName evidence="5">Acetyl-coenzyme A synthetase</fullName>
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        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
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        <reaction evidence="5">
            <text>acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate</text>
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            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
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        <property type="component" value="Chromosome 9"/>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="entry name" value="ACAS_N"/>
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        <property type="entry name" value="AMP-bd_C_sf"/>
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    </dbReference>
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        <property type="entry name" value="PRK00174.1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
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    </dbReference>
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        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="9">
        <location>
            <begin position="60"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="7">
        <location>
            <begin position="108"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="8">
        <location>
            <begin position="556"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF46765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC72388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="680" mass="75506" checksum="B463A1240D200E0A" modified="2016-11-02" version="1">METAQTVVHNVHPLPDSVPESEDLFPPPPRLRGQEGRPKPHIGPNYQSYLNEWKKTVGPNSDKWWFEKANECLDWYTPFKTVRAGGFENGDVQWFPEGTLNASYNCLDRHFYKNPNKTAIIYEADEPSESREISYAELMRETCRVANVLKSWGVKKGDAVSVYLPMTWQAAAAFLACARVGAVHSAVFAGFSAESLRDRVNDCECKVLITTDEGRRGGKSIATKAIVDAALQQCPLVEHVLVLRRTGNKVPFTEGRDKWWDEECAKVPTYCPCEPMASEDPLFILYTSGSTGKPKGVVHCTAGYLLGAYLTVKYVFDVHADDKFACMADVGWITGHTYIVYGPLANGVTTTVFESTPVYPTASRYWDFVDKWKATHLYTAPTAIRLLRRMGEEHVKNHDLSSLRVLGSVGEPINPEAWHWYNDYAGKKNCAIVDTYWMTETGSIVVTPLPGAISTKPGSATFPFFGMDVDIIDPQSGQVLQGNDVEGVLVAKAPWPSLARTVFKDHKRYLETYMKPYPGYFFFGDGAARDYDGYIWIKGRVDDVINVSGHRLSTAEVESALILHKGVAETAVVGSHDDITGQAVYAFVTMKPEFDLKSTKEADLNKELAIQVRKVIGPFAAPKKIYLVTDLPKTRSGKIMRRILRKIVAGEGDQLGDLSSIADPSIVDEIKEKVGAAVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HU30</accession>
    <name>A0A1B9HU30_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_07158</name>
        <name evidence="3" type="ORF">I206_106356</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894015">
        <property type="protein sequence ID" value="OCF46771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007990.1">
        <property type="nucleotide sequence ID" value="XM_019158852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HU30"/>
    <dbReference type="STRING" id="1296096.A0A1B9HU30"/>
    <dbReference type="GeneID" id="30175527"/>
    <dbReference type="KEGG" id="kpin:30175527"/>
    <dbReference type="OrthoDB" id="4850at2759"/>
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        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37948:SF1">
        <property type="entry name" value="BLL5189 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37948">
        <property type="entry name" value="ZGC:113208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF46771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC72394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="347" mass="39340" checksum="0CA85B896148F74E" modified="2016-11-02" version="1">MATLADENGLLVNSQFSEGEEGEDLNELEDYEKQRIANIKQRDTLLASLGLSNSSNQIFGSGSGSRTKLNSNEIRRKKELKIKEAAFKKQFNEPTRRSGRIAAKEVEYKPLVDDDDLTPPPTLKPQPLIPKGKPISLAPGPSYSDEEDEETFKSAPRPTRGDDGRLIFEGRWKGVFTPNLTPEEMFKGGAFGGGFFADTYSNILKTPLNSIDDLHSLPFTLSNSEELLINQSPDGENNRWKVRAGQSLQEWEKAGWIWAEDPRGWAQWYTRFWDGRRCRDDDRQVRRWLKVAGSTGRFKRALLKKLMQSGGKSSIADEDIGAVLRQCLWQWAYELNEKEFDKAMNGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HU67</accession>
    <name>A0A1B9HU67_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_07201</name>
        <name evidence="6" type="ORF">I206_106397</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the GSE complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
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        <property type="protein sequence ID" value="OCF46814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC72435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008033.1">
        <property type="nucleotide sequence ID" value="XM_019158895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HU67"/>
    <dbReference type="STRING" id="1296096.A0A1B9HU67"/>
    <dbReference type="GeneID" id="30175570"/>
    <dbReference type="KEGG" id="kpin:30175570"/>
    <dbReference type="OrthoDB" id="10020193at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11384">
        <property type="entry name" value="RagA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000488">
        <property type="entry name" value="Small monomeric GTPase (Gtr1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039397">
        <property type="entry name" value="RagA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF1">
        <property type="entry name" value="RAS-RELATED GTP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
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                <person name="Chen Y."/>
                <person name="Heitman J."/>
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                <person name="Young S.K."/>
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                <person name="Litvintseva A."/>
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                <person name="Mohammad A.W."/>
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                <person name="Yurkov A.M."/>
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                <person name="Heitman J."/>
                <person name="Sun S."/>
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                <person name="Young S.K."/>
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                <person name="Gargeya S."/>
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    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
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                <person name="Hansen M."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">CBS 10737</strain>
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            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
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                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Mohammad A.W."/>
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    <dbReference type="OrthoDB" id="2804112at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCF47498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC67719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="36150" checksum="A2D1439652FFF5F0" modified="2016-11-02" version="1">MSFIIDCSTSLDNDGRYDIDTDLIFFQHPRSGYNAGVSTALRGSTSNNVPPELLIAAQLSPPVQIRGLTRQLSRVKPSSTIADGSISESAANVVNVIRRLAAGSLWDYWLIRHPIYGTAVLKLIEEAVKEDGFYVGPLLGLQGDVVPRYYGLYQTIGEYRYYAMLLEYIPHPLGSGFLLLSQEWNGVLHRDIDIRHILVDDHDRVCLVGFRHSKLLSLKEENDVDRIMGELGAIRMGIGLEDEEDITTDTIPRSYFELLPDPEGYIQEMKDIESQPEPDWLDNQVMRADPWGVPDLSSVPEETTITAENYRYWEQQRATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HWB6</accession>
    <name>A0A1B9HWB6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutathione hydrolase</fullName>
            <ecNumber evidence="8">2.3.2.2</ecNumber>
            <ecNumber evidence="8">3.4.19.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Gamma-glutamyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Gamma-glutamyltranspeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_06439</name>
        <name evidence="12" type="ORF">I206_101591</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 8">
            <text>an N-terminal (5-L-glutamyl)-[peptide] + an alpha-amino acid = 5-L-glutamyl amino acid + an N-terminal L-alpha-aminoacyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:23904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9780"/>
            <dbReference type="Rhea" id="RHEA-COMP:9795"/>
            <dbReference type="ChEBI" id="CHEBI:77644"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:78599"/>
            <dbReference type="ChEBI" id="CHEBI:78608"/>
            <dbReference type="EC" id="2.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:59468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>glutathione + H2O = L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:28807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Sulfur metabolism; glutathione metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-glutamyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.2" evidence="8"/>
    <dbReference type="EC" id="3.4.19.13" evidence="8"/>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008757.1">
        <property type="nucleotide sequence ID" value="XM_019158144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HWB6"/>
    <dbReference type="STRING" id="1296096.A0A1B9HWB6"/>
    <dbReference type="GeneID" id="30174808"/>
    <dbReference type="KEGG" id="kpin:30174808"/>
    <dbReference type="OrthoDB" id="1081007at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103068">
        <property type="term" value="F:leukotriene C4 gamma-glutamyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.40:FF:000001">
        <property type="entry name" value="Gamma-glutamyltranspeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF9">
        <property type="entry name" value="RE13973P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="523"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="541"/>
            <end position="543"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="565"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="593"/>
            <end position="594"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="621"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCF47538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC67679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="720" mass="79475" checksum="95A2D2A77300B629" modified="2016-11-02" version="1">MSSTPFRRSEEISETNPLLTNSIEDANAEEEGLDRPLVERRLSPAWQFWNHPPFQKRVRFDDVTDTRRYSQHTEDDESILPISNENENHKIHKHHHRPLYQKYGQWVMYMILILLGMIIGTIFSREFWKRNNELGDGPMVPPVWTLPPPTGLPRNEAYLIQAQNGAVASEDKTCSDLGLSILKDKNGSAVDSAITTTLCIGLLNGFSSGIGGGGFMVIRIPQIYNSSFELVDELISEGEEKVIAIDFRETSPDKSEKEMYGEKKAGRVAAQVGGLAVGVPGELRGLELAHQMYGKLPWEEVVMPVAELARGWRVSRELARRLRLFGQFMLSSPAWSAVYAPRGTLLVEGEYVQRINYGKTLEVIAREGAQAFYEGEIAASSIETIGSAGGVMDLDDLKGYKARAYTAIHSRFMGKEVYTTDVPSSGGILLAFLRLIEPYNIPFTGGLKSPLNVHRLLEGMKFAFGARSEITDPAPQFGGNLTRFEEFYKGDWADEKRKMLDDNRTHPIEYYGLQHDTPIDHGTTHLSVLDQWGGGASVTSTVNLIWGSHVMDPKTGIIFNDEQDDFSVPGAADAFGLWPSPWNYPQPGKRPLSSTSAAILLTPATKQSPSSIYAVIGGSGGSRIFPSILQVLLNLFSGMDISQSIEACRVHNQIVPPLTTIEVGPEGSPEEIIKDLKERGQEVGEFDVNIGISEVQAIVIENGTIWAASDSRKNGVAAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HWE4</accession>
    <name>A0A1B9HWE4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">serine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Seryl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Seryl-tRNA(Ser) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I206_06495</name>
        <name evidence="15" type="ORF">I206_101533</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="15">CBS 10737</strain>
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    </reference>
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            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
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        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
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<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
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        <name evidence="3" type="ORF">I206_101518</name>
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        <lineage>
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            <taxon>Agaricomycotina</taxon>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">CBS 10737</strain>
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    <reference evidence="3" key="2">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Shea T."/>
                <person name="Sykes S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
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                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 10737</strain>
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    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <property type="match status" value="1"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF47607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC67608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="70" mass="7935" checksum="DE13B3FBAF11BD5D" modified="2016-11-02" version="1">MATIYRQAQRMAHESPVIFWSLAMGFAGPIMVLTVPPIRKSFGYKQAERIPTTFPVPNRPRRAVSGYEDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HWN3</accession>
    <name>A0A1B9HWN3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_06593</name>
        <name evidence="3" type="ORF">I206_101436</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008906.1">
        <property type="nucleotide sequence ID" value="XM_019158293.1"/>
    </dbReference>
    <dbReference type="STRING" id="1296096.A0A1B9HWN3"/>
    <dbReference type="GeneID" id="30174962"/>
    <dbReference type="KEGG" id="kpin:30174962"/>
    <dbReference type="OrthoDB" id="129353at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd17724">
        <property type="entry name" value="BRCT_p53bp1_rpt2"/>
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    </dbReference>
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        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047250">
        <property type="entry name" value="BRCT_p53bp1-like_rpt2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="294"/>
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    </feature>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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            <begin position="1091"/>
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        </location>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
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        </location>
    </feature>
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        <location>
            <begin position="126"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC67528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1390" mass="152097" checksum="845D628E62D74E95" modified="2016-11-02" version="1">MPPEITIQSQESTQQPSIEIQPATVATSAEPPLSTVNEESPEILNSDARSSTEASLGRNGFQGSSVEETGESGLNWTQSQIKQNQRLLVDKPEGRSNELNEDLEVQATVWETSLPDQGRIQAGTEQIDDQLAEESEDEVITSPDIPGPSNHPRWNTRSPVTKPQTTARASSPLTELDELANDSSREMLDLEGGLEETEVDVPQIQTPEQSPPPSTPPARRVNSFRSPTSPQVDVSGRKLRGVTSYSPSKFLTSSNGHQSNRKSTDMTPFKPFASEKTLMINKRSEPSQDSEESLFGKEAEIVKKLKPIENLQRILSGNADATVRTEPSRLLRRQPLNGMADKEEQEGQPDSGSSQNNGTNVGAPKGHIDGTQEEQEDEQEGVNWEKSLPVNGDTFTDRFSQTSPTPPQPHIPPNMPSSPHQSQSQSQSLPAGNNTRLHHFAYSGSIASQGAIHLSDGLFSDVGDEVPDFSQSQHDVLLPATQMFARQSSPYQAPLESLPEETRSSRASVASQPDDTQLNEQELPSAKTHADNHFGPPSAISRAASTTSITSRISVPSHRQLARRIRTRENSEEALPTTTILFTEQPSGVHKSPGGDTTRRAVSRAPSDLSTTSRISVPTHRLLTRRKRAQDESDVFPPNLHRTASAVPTETPALALKLNQSETAIPRAGSSPFKKSSPHRVSSEPPMLQETLRNSIPSGSSLPQGAQHAAQNSVDAEISPAEAVLKYTSPVAPSFPFRRSLSPTSPSLKAVNNLVPPNLPSILEKTQMDEKPDEPAAAGSKQDDPTLQPAPAPRTSPKHYAGRNKRKRIVSSPNSDDGMKTDSSSTTPEDEEDHTYRPVPETKLPKKMSIKAHGASSKPRDVSKSPDPLLLSSKRKRKPIVRSSSACNPPSDSQSSSSAPEDLEDNTYQPSLLPKLKNPLIENTRKRGSAPSSTSSGIHVTKKVKKIHNNAQVARLSPSISISSLSEAVTAKPERFAVLAAFFHRYYAGEAVWTGRAYNIEFCDGEKKQNVKPDMMRRLILKKGDALEGVESTLPKHLEVAQDWDGHVRGVKCVSLKGEKLGRVPLKDFGINNKVIHASFSDRLFEDPHASKITRSDGHKKPSIPRSPTKRSGAVYGTPSKSARSNSPTRLISNRLKGMLFFITKGTRDDQASITLAIRQNAGKITTDWEDLFDKSSPGGYGFDKNLDGTPFLILLGGSKGGTIITPKAMVALAKGIPCLSERFVDDISEGNDVDWRSYLISPGFSIHVEHYMSQVVDIAWGGEGWDPEIAGPIRRPMKGKTILFVLPGPKFEGLKRLIPVCAYSMGADELHTVTNTKTSENTIKDSKWNYILFEDREYIDKHGNSKSLPKWLSDEKDRLVNVHWLKQCLITGRALPPSLDLEKTEEKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HWV3</accession>
    <name>A0A1B9HWV3_9TREE</name>
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        <recommendedName>
            <fullName evidence="5">Cytoplasmic protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_06645</name>
        <name evidence="3" type="ORF">I206_101385</name>
    </gene>
    <organism evidence="2">
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        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Cryptococcaceae</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC67477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008958.1">
        <property type="nucleotide sequence ID" value="XM_019158345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HWV3"/>
    <dbReference type="STRING" id="1296096.A0A1B9HWV3"/>
    <dbReference type="GeneID" id="30175014"/>
    <dbReference type="KEGG" id="kpin:30175014"/>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="PFA-DSPs"/>
    </dbReference>
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        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
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        <property type="entry name" value="Siw14-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF74">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE-LIKE PROTEIN OCA2"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF03162">
        <property type="entry name" value="Y_phosphatase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01911">
        <property type="entry name" value="PFDSPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF47739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC67477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="23135" checksum="31E7C68D7A7DE44C" modified="2016-11-02" version="1">MPSEMFVESDDNPPIVVPPINFSLVVPGIYRSGHPNKKNFNFLKKLNFKTIIYLENENENEKEQEKYRKDFLNFINININDENENENKIIIKRFDLSKESNLFTLNGLNKLNELLKIILNFKNYPILLHDDNGKGTVSLICALIRKIQNWSLTSIFSEGDLFAGPASGSEGVGLGEAGMEFIASFEPKKVVFDKKYKPDWVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HXL0</accession>
    <name>A0A1B9HXL0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_05866</name>
        <name evidence="11" type="ORF">I206_107538</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894014">
        <property type="protein sequence ID" value="OCF48000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009219.1">
        <property type="nucleotide sequence ID" value="XM_019157579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HXL0"/>
    <dbReference type="STRING" id="1296096.A0A1B9HXL0"/>
    <dbReference type="GeneID" id="30174235"/>
    <dbReference type="KEGG" id="kpin:30174235"/>
    <dbReference type="OrthoDB" id="16510at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008504">
        <property type="entry name" value="Emc6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029008">
        <property type="entry name" value="EMC6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07019">
        <property type="entry name" value="EMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF48000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC73566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="138" mass="14799" checksum="C01C22EA8394C726" modified="2016-11-02" version="1">MNPTAPPPTGAHLAPEASPLHPPSVIHNTRILSSLGTYSACFSGLIAGLLGLTNLYGFALYLISSIFTSIILLLFKCNGDVIKYVAQSHSNLSNGENGTFGNGKKWKGYWALSGIGQENLLGFLLFWIGSFALIHVYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HYH4</accession>
    <name>A0A1B9HYH4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_06182</name>
        <name evidence="12" type="ORF">I206_107851</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894014">
        <property type="protein sequence ID" value="OCF48314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009533.1">
        <property type="nucleotide sequence ID" value="XM_019157893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HYH4"/>
    <dbReference type="GeneID" id="30174551"/>
    <dbReference type="KEGG" id="kpin:30174551"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF53">
        <property type="entry name" value="ALPHA-GLUCOSIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="481"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="59"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCF48314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC73879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="585" mass="64649" checksum="75EA39559A10EC1A" modified="2016-11-02" version="1">MVGVSFKKETDIVKLTEDQLHAVSHLDPELVRIGHEVIENQKKEGFIQAWRNHGRAAGWSIFLTSALLMEGFDTAIINSFFALPAFLNSFGVKGKKGKLAIPANYQSGLVNIAYVGQIIGLFLNGWCQERFGSRKTFIGGMIIMTLTIFLAFFAVSLNMLLVAELAMGIPWGMFQTLSTAYAAEICPIQLRGYLSAFASVGFGGGSFIASGVLRACLSITGEYGWRLPYALQWVWPVPLALGCYFAPDSPWWLVRKGRIEEAEKVLIRCARPGFYAEKEAQGFIAFMQHTDALEKLDAKGGSWKEMFKGVNLRRTEIMFGVWLVQLWNGNIITGLTVEMLENAGMSATAAFNMNLVLSAMSIIGVAISWVALRYTGRRKIYITGIALEACCLLPIGILGTVAQTNARLNAMGALMIIINLLFHFSLGPVCYSIVGELPSSRLRSRSIVLGRFVYVVSAIIASQLRARMVTATAWNWQAKSAYFWLGCNLICLTWTFFRLPETGGFSFAELDILFANKVPTRQFTKVKIRNDAAEIGTEKQIHDQDHDEGKGEIEHVEGGTVLDPEERAVVQLEEVPGHVPQNSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HYV1</accession>
    <name>A0A1B9HYV1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SDE2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_05212</name>
        <name evidence="12" type="ORF">I206_107243</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDE2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC73277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009653.1">
        <property type="nucleotide sequence ID" value="XM_019156935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HYV1"/>
    <dbReference type="STRING" id="1296096.A0A1B9HYV1"/>
    <dbReference type="GeneID" id="30173581"/>
    <dbReference type="KEGG" id="kpin:30173581"/>
    <dbReference type="OrthoDB" id="547031at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053822">
        <property type="entry name" value="SDE2-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF1">
        <property type="entry name" value="SPLICING REGULATOR SDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22782">
        <property type="entry name" value="SDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SDE2-like" evidence="10">
        <location>
            <begin position="78"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCF48434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC73277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="260" mass="28384" checksum="C2937657C73246D1" modified="2016-11-02" version="1">MLQTIQINLPSPLLAKTIHLTPQQTISDLFTYTELSFEDVYLRTRSSGPLSPSTSISSLQHGDTNHLIEINVCARLLGGKGGFGSQLRAAGGRMSSGKATNMDSCRDLSGRRLGTIKEAQRQAELLESAPALRAKLAAEEKSKLEALERQLGISQPDALDDQNGEGSSKRKVEDVNLEELAAKKHKFDDNKFLEESREINDNVRNAVSKAMLLKKKKKTASASATAKSDVKTKGREKVEEITKKEKEKMAMPPPALANVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HYV6</accession>
    <name>A0A1B9HYV6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ZZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_05248</name>
        <name evidence="9" type="ORF">I206_107207</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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                <person name="David-Palma M."/>
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                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
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                <person name="Sun S."/>
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                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
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                <person name="Berlin A.M."/>
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                <person name="Nusbaum C."/>
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                <person name="Litvintseva A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
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                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
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                <person name="David-Palma M."/>
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                <person name="Bowers K."/>
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                <person name="Mohammad A.W."/>
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                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
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                <person name="Cuomo C.A."/>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
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                <person name="Dewar J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
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                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="11"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="452"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="503"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="187"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="468"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF48633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC73079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="579" mass="66436" checksum="973ACFC8B79C16EA" modified="2016-11-02" version="1">MGRSRLEDVTCAICYDSLFNKRDDLRDLIPIATCDCGHVFHEPCLLEWFRTQSEQYLAAAREQGIDGRFGSPTLSDAPAECPSCRAECFADPETGQPSIHRLFIDFDNIFDNNNNSIIGSSPPPSSKMDKKGKGNAKEEEFLNLARRAKGIREEVKGLNAESTEEHMEGMIRRGENLVMDLIGIQVLDTVKNYIEGLTKEIKTLRKTLESNPLNPGLRERISTLRDQIINLERQSRLSLQREVRKVKDEEQARCERKVKRAEEERDLLQRAYEKEKVSRKTGMRSMEERVVDLERRLEEMSEQLKKEKEDRVALQATLQERTQQLKLSTKRVEDRKDLKRQLSVLQKENDKLITRIQSHQLVDKPEIEKEDNSVQEISRSRFPRLASSPSIHAKVEEDESLQIDMPAYDDSFVSPDRLLPARTTLKSLKTGNHHLEGGRHGRKHPTARIMEFNLEGDKENKNRRRSTSSKYFPSSSSVSDEEESPKKYPIKKKLTVNEEINKRSLTNPFQTTKQSVQRRQQLPTLGNTSNNGVIDLTESPNSSKLLKKDSNTASILRLADRNGRPLKGVVSGQKMKRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HZL3</accession>
    <name>A0A1B9HZL3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Importin beta-4 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_05451</name>
        <name evidence="11" type="ORF">I206_107006</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC73041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009890.1">
        <property type="nucleotide sequence ID" value="XM_019157172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HZL3"/>
    <dbReference type="STRING" id="1296096.A0A1B9HZL3"/>
    <dbReference type="GeneID" id="30173820"/>
    <dbReference type="KEGG" id="kpin:30173820"/>
    <dbReference type="OrthoDB" id="7862313at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="9">
        <location>
            <begin position="27"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="8">
        <location>
            <begin position="516"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF48671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC73041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1081" mass="118122" checksum="8C4A84F50B2F8CCB" modified="2016-11-02" version="1">MDPNYVSQLRQLLEHTIAPDTNVIKAATTQLNTQFYKSPQCIPALYEIAATTDNQSIRQLAAVELRKRISSGDGRQWKKNPQELREQIKSSLLERLTQEQSAIVRHALSRAVAAIADIELTVNPPQWPTLLPGLYQAAASPTKTHRETAIYVLFSILDTVAESFETQLQSLFKVFSQSLVDPESSEVRVTTLRALAKVAEYIEAGDKHDVKAFQELIVPMLKVLEQAITEGDDEGVKHGYDAFETLLIIEAPLVSKHVAELVQFFLGVAGNKEVDDEMRCGALNVLSWVVRYKKSKVQALGLAKPIVEGLLPIGCEDDPEDVDEDSPSRLAFRTLDNLAQALPPQQVFPVLTQQLQVYMGGDARMRKSALMAFGVSVEGCSEYIRPHVDQLWPVIEGGLQDGEVIVRKAACIALGCLCEWLAEECATRHAIIVPILFNLIVDPSTQKNACTCLDSYLEILGDDIVNYLTLLMERLLVLLENGTIAVKITVTGAIGSAAHAAKEKFVPYFDQTIKRLVPFLHLQASDEESDLRGVATDTIGTIADAVGADVFRPYFEGLMKAAFEALTMDNSRLRESSFIFFGVMAQVFEGEFAQYLPQCVPALIASCQQDESADEFLNDGEGGSSNPSALAEAFTTGTSKDAGEDLDDEEDETDLAALEQMFSKVNSAVAIEKEVAADTIGELFSATKSAFMPYVEETVKVLVELLDHYYEGIRKSAVGALFAFVKTMYELSEPAEWQPGAHVRVPLHEHVKKIVEMVLPPIFEAWKTEDDKSVVILMCAELADTMNKCGPAIVEGHLDEVATFAIEILEKKSLCQQDPDGDDENVGVDADSSEYESALVSNAADVFGAMASVLGPDFAQAFGQVLPLIANYTEPKRAQSERSMAIGSLGEIIVGLKDGVTTFTQPLLQIISRGLVDEEADVRSNAAFAAGVLIENSSTDLSSNYQALLAALQPFFSPAEHSAPAIYNARDNAAGAVARMVIKNPSALPLEQVISVLVSVLPLRFDPLENRAVYGALFSTFRNQPQILMPHIDHLLQAFAYVLLDPTHSDDTTDETKAELKALIEHLKSQVPDKVSSAGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HZN0</accession>
    <name>A0A1B9HZN0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein BTN</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_05517</name>
        <name evidence="11" type="ORF">I206_106940</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Vacuole membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the battenin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC72976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009955.1">
        <property type="nucleotide sequence ID" value="XM_019157237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HZN0"/>
    <dbReference type="STRING" id="1296096.A0A1B9HZN0"/>
    <dbReference type="GeneID" id="30173886"/>
    <dbReference type="KEGG" id="kpin:30173886"/>
    <dbReference type="OrthoDB" id="5965864at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003492">
        <property type="entry name" value="Battenin_disease_Cln3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981:SF0">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02487">
        <property type="entry name" value="CLN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01315">
        <property type="entry name" value="BATTENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF48736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC72976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="536" mass="59287" checksum="F8BC2EB258AAB813" modified="2016-11-02" version="1">MPDSNLPLQPMGPDFHERRPLQSESHARDDSSIDEDDVDDFTAANDESLKNVTASKYTNKRLFAAFMIFGLLNNVLYVIILSAALDLVSSSTPKGIVTLFNIFPALATKVAWPLISNGKIQYTRRVGLCTCVSWLGIMTIAFSTSLAPRLLGISMASLSSGLGELTFLQLTTTLPTRSTSKTALGAWSSGTGFAGIAGAGIWWLLRGLGVKGGLGLSSFLPLFFPITYTFLLPSRAELEAISDDITGLGEYEPINTDSIPPSIFITPPSQDVVPQLSSSSASRTRLQEPNDDLKPISEEYQKVYLSTKEKLDLLKPLVFRYMIPLCAVYVEEYVINSGVAPTLVFPIPTHGIWSKLFKSPRDYYPFWSLTYQTFVFLSRSSISLSIPPIPLKFLPLPSIIQFIILLLLSLQSKYFIFTKSNFKPKPLKKIILKNSDEIDNSITIIFYLICLEGLCGGLAYVNTFYHVQNEGTNESQNENENSKEKEKENLKKEFRIGSVGAADSTGILFASLISIPLELNLCNSQIEQGRTMCRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I0P3</accession>
    <name>A0A1B9I0P3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FCP1 homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_04771</name>
        <name evidence="4" type="ORF">I206_105948</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC71989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010303.1">
        <property type="nucleotide sequence ID" value="XM_019156501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I0P3"/>
    <dbReference type="STRING" id="1296096.A0A1B9I0P3"/>
    <dbReference type="GeneID" id="30173140"/>
    <dbReference type="KEGG" id="kpin:30173140"/>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009651">
        <property type="term" value="P:response to salt stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000043">
        <property type="entry name" value="General stress response phosphoprotein phosphatase Psr1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="431"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF49084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC71989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="604" mass="64686" checksum="E7F5C626E971FB54" modified="2016-11-02" version="1">MASSQIDTSSSNTPASEQVKSQSQSETKNVESISYPSVQKQSPIILGPPSLTVTPASPTTTQTNTVADPSDDPSASTTTDEQVIAKEMKEKANHPTDSETALLTQQSSTMESNTDETVNGGSKGVSGSSPLANLTRRLSGKSSSPNTNTSKALDTTSKEKPSTSTTTNTTTKAIPNQASSSTTRPTNASSTQKASQKKKKKRKGLAGFLLTLECLSADEFEEDPKKVNRAQQTTTQKPGTSVTTSQSTAAPSTSQPKDKKIDDNLVNNEGSSSGHQVEPTTTTGTTLVDTNGEGAVKPDEEIVVAPTEPHTLPVDETAGVTSSAVQPPGGGSSLLGTPTRSHPTRRDSDVVPASTSADQDRTETSGGYTDISNSEIQDESSGVAVEEGVDEYGMEDDYEDEEDRLIEQGGMGIPLDENGQPAPLLPPILKEHLGRKCLVLDLDETLLHSSFKSLPSADYIVPVEIESQIHNVYVIKRPGVDHFLKEMGKIYEVVVFTASLSKYADPVLDMLDTHRVVTHRLFRESCYNHKGNYVKDLSQLGRSIETSIIIDNSPASYIFHPNNAVPVSTWFNDPHDTELTDLCPFLADLSTVDDVRGVLDGRMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I177</accession>
    <name>A0A1B9I177_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">25S rRNA (uridine-N(3))-methyltransferase BMT5-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_04976</name>
        <name evidence="4" type="ORF">I206_106151</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010506.1">
        <property type="nucleotide sequence ID" value="XM_019156704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I177"/>
    <dbReference type="STRING" id="1296096.A0A1B9I177"/>
    <dbReference type="GeneID" id="30173345"/>
    <dbReference type="KEGG" id="kpin:30173345"/>
    <dbReference type="OrthoDB" id="273345at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070042">
        <property type="term" value="F:rRNA (uridine-N3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019446">
        <property type="entry name" value="BMT5-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF26">
        <property type="entry name" value="FERREDOXIN-FOLD ANTICODON-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10354">
        <property type="entry name" value="BMT5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="25S rRNA (uridine-N(3))-methyltransferase BMT5-like" evidence="2">
        <location>
            <begin position="99"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF49287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC72191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="401" mass="46008" checksum="3785E98E2774118F" modified="2016-11-02" version="1">MAKLKAALANQQYNAAKAAAKKRSLQNEENKKQSIKANLTGSKKGSKKQKIKTSLSLQNQSEHNDKEGGENSKKLSSSSSSSNLNKKSIIPFDKTDSILLIGEGNFSFTLSLLNFPHNLNGKQIFSTCFDNKEICFKKYPDSEEIIKDLIKKGVKVEFGIDATCLEKFKVLGKGKKFSKVIFNFPHVGAGITDQDRNILTNQHMLLKFFRSVEGFLTDGPEELTTKEKNKNKRKLSELNSDSEEDENENEMEMEEEEEEESPYIIEEKEGNENQFISFRNFEKQEEQKELKIPNKKGSILITLLNCLPYKLWSLTKLATKPPFFTPGLGGESKKFKQPRYKLKRSFKFDLNLYKNYEHRRTIGFKKGLSKSKNEEILRKNGDARMYEFVLKNNDNSKDQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I1G5</accession>
    <name>A0A1B9I1G5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_05072</name>
        <name evidence="3" type="ORF">I206_106246</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010598.1">
        <property type="nucleotide sequence ID" value="XM_019156796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I1G5"/>
    <dbReference type="STRING" id="1296096.A0A1B9I1G5"/>
    <dbReference type="GeneID" id="30173441"/>
    <dbReference type="KEGG" id="kpin:30173441"/>
    <dbReference type="OrthoDB" id="2348401at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2440">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007250">
        <property type="entry name" value="HSP9_HSP12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04119">
        <property type="entry name" value="HSP9_HSP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002590">
        <property type="entry name" value="HSP9/HSP12_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF49379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC72284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="84" mass="8768" checksum="48899AE183F7E36C" modified="2016-11-02" version="1">MSDTGRQSLTDKAGAALKPDSEKTYLEQGKDMLAGKADSAASTGQPQSQKSYTQEIGDAVSGNSNENQTSIADKAKDALGMNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I1L6</accession>
    <name>A0A1B9I1L6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">MFS transporter, SP family, solute carrier family 2 (Myo-inositol transporter), member 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I206_03953</name>
        <name evidence="14" type="ORF">I206_104466</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
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        <reaction evidence="8">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="kpin:30172322"/>
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        <property type="component" value="Chromosome 5"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
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            <end position="522"/>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I226</accession>
    <name>A0A1B9I226_9TREE</name>
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        <lineage>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
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    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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            <end position="73"/>
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            <begin position="235"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF49603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC70348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="299" mass="32201" checksum="30309F24DC437543" modified="2016-11-02" version="1">MATATATMDDLVASLGGSMHVSSDLKALQEYLAQNMIRPTIQLPLASPNVFSRPIPPSRSTSSTRKPSSLPSSYTYPHETHQAYPSPIAQSSFSAFQEESEGGPGPSTSEMMMMSTPTGITRPGGPLRRTSSYGFGCSIQVAPASPPATYSSFDSDAFAPIWQQRQQEQQQVSDPWAKVKTQQTNAFSSFNPNSAFSGSTGSSSFGNFRQPQGFGLSAGSTGLGQIGGGPPTPPAEDDDEMDEDSIDAEMDDMDDEEDDNKVQRSLGFPVVDSTNQHHNHDIWGRGRGKEIANNGMRYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I335</accession>
    <name>A0A1B9I335_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dynactin subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_04406</name>
        <name evidence="7" type="ORF">I206_104019</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011097.1">
        <property type="nucleotide sequence ID" value="XM_019156139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I335"/>
    <dbReference type="STRING" id="1296096.A0A1B9I335"/>
    <dbReference type="GeneID" id="30172775"/>
    <dbReference type="KEGG" id="kpin:30172775"/>
    <dbReference type="OrthoDB" id="417208at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03359">
        <property type="entry name" value="LbH_Dynactin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047125">
        <property type="entry name" value="DCTN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126:SF1">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21711">
        <property type="entry name" value="DCTN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCF49878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC70073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="189" mass="20608" checksum="C16B9A3DED1072B0" modified="2016-11-02" version="1">MGAFDSIITYEKGTYIETDTGNKVSRKATIIGATNIILGGKSIIQLGSILRGDLKRSISGQNVVISIGRYCLIGENSIIRPPGKLYKGTFTFYPIRISDFVHINSNCIIEAGQIGLGVEIGKNCIIGKFVIIKDLAIILPNTVLTEGTVVPSMSIWGGNPGKLIDTLPETYQETMEAKCKNYYQRFRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I349</accession>
    <name>A0A1B9I349_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein SEY1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SEY1</name>
        <name evidence="12" type="ORF">I206_04500</name>
        <name evidence="13" type="ORF">I206_103927</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="8">Enriched in the cortical ER. Concentrated in punctae along the ER tubules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC69983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011188.1">
        <property type="nucleotide sequence ID" value="XM_019156230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I349"/>
    <dbReference type="STRING" id="1296096.A0A1B9I349"/>
    <dbReference type="GeneID" id="30172869"/>
    <dbReference type="KEGG" id="kpin:30172869"/>
    <dbReference type="OrthoDB" id="1597724at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016320">
        <property type="term" value="P:endoplasmic reticulum membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01851">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000727">
        <property type="entry name" value="Protein SEY1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03109">
        <property type="entry name" value="Sey1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030386">
        <property type="entry name" value="G_GB1_RHD3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008803">
        <property type="entry name" value="RHD3/Sey1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046758">
        <property type="entry name" value="Sey1/RHD3-like_3HB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45923">
        <property type="entry name" value="PROTEIN SEY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45923:SF2">
        <property type="entry name" value="PROTEIN SEY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05879">
        <property type="entry name" value="RHD3_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20428">
        <property type="entry name" value="Sey1_3HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51715">
        <property type="entry name" value="G_GB1_RHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="topological domain" description="Cytoplasmic" evidence="8">
        <location>
            <begin position="1"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="723"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="8">
        <location>
            <begin position="751"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="755"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="8">
        <location>
            <begin position="775"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="domain" description="GB1/RHD3-type G" evidence="11">
        <location>
            <begin position="95"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="105"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCF49969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC69983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="844" mass="94862" checksum="F08FDA3A4351AD2A" modified="2016-11-02" version="1">MNQTPETASNLLANPPPELQRILDDPRTTDEARQAVKEVSVVSPPPVQNGLASTPKEPNGTNHSGEGRLQIVNEHQEFTKQLSPYLDKWGLLDKGFAYDVVSVFGSQSTGKSTLLNRLFGTTFDVMDESKRQQTTKGIWMCPSTYGNTLVMDVEGTDGRERGEDQDFERKSALFSLASTEVLIVNLWEHQIGLYNGANMGLLKTVFEVNLGLFGGGGDSSKPKPQEKTLILFVIRDHVGATPVSNLTATLTQDMEKIWASLSKPSHLADATLSSYFDLSFATLPHKILMPEKFEDEVLELRRRFTDRSRSDYVFQPSYHKRIPADGVGFYMEGIWQQVLTNKDLDLPTQQELLAQFRCDELSAAVTEIFLASSKIVRKPVEAGQVVEGLGALMKDWLDTALGKFDRDASRYHAGVYQRKRLDLLTGLHASLSSLFLGQLKNLHKIETAKFSKDIVRGTKEVGYDFAKVVNEGSDNARQRFLDGAKEVKIDGTDWEYEHELALLDEDLKSIADRCRADETKKMVNTIERNVKRQLLEPVEVALSQPSVEMWNIVLKTYKQVNEDAEQSYLTKAKAYNCSEEENNAALLSLRARTWLSLRRKLEEQTSDATILATLRSTFEEKFRYDESGVPRVWKPEDDIESAFTKAKEETLSLLPIFASISPTSSSLLPTLPSPESTFDIESDPIPFDPSTAFVLLSPTKILSIESRFKREADAAYVEAKRSMVSSVAQIPLWMYGILIVLGWNEAMTVLFNPLYFAMILVLGASGYIILQLGLAGPLLQICKTVFYEVKRIATDKLREAFKELPENQKQQILNTPYLSNTLNDGLKNEERKKGDLINEKMIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I3B6</accession>
    <name>A0A1B9I3B6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_04557</name>
        <name evidence="2" type="ORF">I206_103871</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF50026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC69927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011245.1">
        <property type="nucleotide sequence ID" value="XM_019156287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I3B6"/>
    <dbReference type="GeneID" id="30172926"/>
    <dbReference type="KEGG" id="kpin:30172926"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCF50026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC69927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="421" mass="47983" checksum="A9D44AD841C3B3C8" modified="2016-11-02" version="1">MSQIHRQTSLNAEGSGLQQTRATEIRSQLDKLGLQLTRFGLAHDEAQPRYALDSIRDDDRARFTDFHRDQVVNTLINKPVIKLCGDSVSLELTQQDADWIPTIHVDLSNLGPMINKYTSSDNATAEEQFCLNTASTFRRSLPSHLLQCMRQKDFLSLNEASVRLCLGHTLADIVRDDDDYHKKEGEIRSKLEVMWSEGSQSQINLEKAYLLAHGEKHAGYIRSEGKGFNPDAGMYELRQSNALLPTFSPAELNDHLTTVTKRGDEAEAARDARKEQGLTRSWDEWGRSRVSNLTEDRKREIEEQMALREKQFEGSLDSAITSCVSQQGYLKDNEWQSKGNLFSIFYTPGLGYSSIDKTGLGGRIVKFDPNVDVKVKYWKRRDGPNDNESWRQVTYVPSMDYYQSQIEKAKDFSVQDLLKQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I482</accession>
    <name>A0A1B9I482_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylserine decarboxylase proenzyme 1, mitochondrial</fullName>
            <ecNumber evidence="12">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 1 beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 1 alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="12" type="primary">PSD1</name>
        <name evidence="14" type="ORF">I206_03654</name>
        <name evidence="15" type="ORF">I206_105440</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="12">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Phosphatidylserine decarboxylase 1 alpha chain</molecule>
        <subcellularLocation>
            <location evidence="12">Mitochondrion inner membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Intermembrane side</orientation>
        </subcellularLocation>
        <text evidence="12">Anchored to the mitochondrial inner membrane through its interaction with the integral membrane beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Phosphatidylserine decarboxylase 1 beta chain</molecule>
        <subcellularLocation>
            <location evidence="12">Mitochondrion inner membrane</location>
            <topology evidence="12">Single-pass membrane protein</topology>
            <orientation evidence="12">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="12">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="12"/>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011554.1">
        <property type="nucleotide sequence ID" value="XM_019155400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I482"/>
    <dbReference type="STRING" id="1296096.A0A1B9I482"/>
    <dbReference type="GeneID" id="30172023"/>
    <dbReference type="KEGG" id="kpin:30172023"/>
    <dbReference type="OrthoDB" id="4330at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03208">
        <property type="entry name" value="PS_decarb_PSD_B_type1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033661">
        <property type="entry name" value="PSD_type1_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF6">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5023243593" description="Phosphatidylserine decarboxylase 1 beta chain" evidence="12">
        <location>
            <begin position="1"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023243592" description="Phosphatidylserine decarboxylase 1 alpha chain" evidence="12">
        <location>
            <begin position="493"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial matrix" evidence="12">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial intermembrane" evidence="12">
        <location>
            <begin position="114"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="35"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="294"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="493"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity" evidence="12">
        <location>
            <position position="493"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="12">
        <location>
            <begin position="492"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="12">
        <location>
            <position position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCF50335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WWC71482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="529" mass="58906" checksum="400B4E8E0764F75E" modified="2016-11-02" version="1">MIIRHSTRVISKASIPLRSTSALFNHNSRQHIRSPLISTRWNSNIPKQPYTPPRINEKPSLQEDQSGTGQSSKGKPLNEKVAQAWSTPTRWYPIPIALGALVLLAVQYRKSTRSDIEVESQGEGGAVVKKGGKRVDGPWQVRVLGALPLRSLSQLWGYLNGLVLPVWFRPFGFKLYATIFGCNLDEVPKDLKEYESLGDFFYREMKEGQRPISDAPMVSPADGRVLHFGEIVGSRVEQVKGITYSLEALLGSESSIHGDTQSVQNKGERVDEKNFANINDISYSLSSLLGRGSDNGETKSYEDASLPKTSDKEADASHTENGPEKTIHDGKVAKVLGKLAWFGHKTSSKSELLPKINTPENNLYFMVVYLAPGDYHRFHSPTTWIVERRRHFTGDLFSVSPYIANRMKDLFVLNERVALLGRWKYGFYSMIPVGATNVGSIKINFDQSLRTNTRKITHPPHTYAEAVYSSASSIVNGQPLLTGEEMGGFKLGSTIVMVFEAPKNFKFQVEPGQKVKMGQTLGKLEGEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I4B2</accession>
    <name>A0A1B9I4B2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">THUMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_03686</name>
        <name evidence="5" type="ORF">I206_105408</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011584.1">
        <property type="nucleotide sequence ID" value="XM_019155430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I4B2"/>
    <dbReference type="STRING" id="1296096.A0A1B9I4B2"/>
    <dbReference type="GeneID" id="30172055"/>
    <dbReference type="KEGG" id="kpin:30172055"/>
    <dbReference type="OrthoDB" id="367221at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11717">
        <property type="entry name" value="THUMP_THUMPD1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2300.10">
        <property type="entry name" value="THUMP superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040183">
        <property type="entry name" value="THUMPD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452">
        <property type="entry name" value="THUMP DOMAIN CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452:SF10">
        <property type="entry name" value="THUMP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143437">
        <property type="entry name" value="THUMP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="THUMP" evidence="3">
        <location>
            <begin position="186"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="316"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF50365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC71452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="423" mass="47166" checksum="0E245C76B4A6314B" modified="2016-11-02" version="1">MSGQPGASGEKRKAQGGPSTQKHKFYKFKGQNRGGRGGGGRGRGGGGRGERGGGSTRLPRNDGHDDGKPKLNPLGKYRINPLPDILTAPGICVTTIMNKERSAEAELIDYLERIADEIYPETIEDDVEREGSEDLDFEAQLKKDLESMDQNNKSKRFRLCVHDMICVIYINVLPPLSPYKLVRHIMEQAESSARTQLKWCKRIIPIDGTSKATVKQLSELAAEIVKDGFKAEDSRPIKYAIDTNTRQSDRLERMSMIHTVAKQVSLLDKSHSVDLKNPEKTILLELYKNSVGMTILDDYERFKRYNPSSIASAAAQAKGKSQMNENSELSRSAKPVDVASQAEETNNQVTGTPKHIYRERRAEAIASKYTQNDLNKNDGQNDDHVEKDAEAGEILEEPQGILGEDWEERVANGKLERVRKDGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I4C5</accession>
    <name>A0A1B9I4C5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 18">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="7 18">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">I206_03691</name>
        <name evidence="21" type="ORF">I206_105403</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="21" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 19">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 18">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="7 18"/>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011589.1">
        <property type="nucleotide sequence ID" value="XM_019155435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I4C5"/>
    <dbReference type="STRING" id="1296096.A0A1B9I4C5"/>
    <dbReference type="GeneID" id="30172060"/>
    <dbReference type="KEGG" id="kpin:30172060"/>
    <dbReference type="OrthoDB" id="275353at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000019">
        <property type="entry name" value="Phosphoglycerate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000031">
        <property type="entry name" value="Phosphoglycerate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="entry name" value="Phosphoglycerate kinase, N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406:SF0">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="12 18 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 18" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="24"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="64"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="372"/>
            <end position="375"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
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            <dbReference type="ARBA" id="ARBA00016471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
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            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
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            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU000696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OCF50370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="WWC71447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="417" mass="44894" checksum="19033434AE73EE9A" modified="2016-11-02" version="1">MSLSSKLSITDVSLKGERVLIRVDFNVPQDKELNITNPARIVAALPTIKYAIDQGAKSVILMSHLGRPDGSPNPKFSLKPVASKLSELLNKDVKFLDNCVGEDVKKAVLAGENGQVFLLENLRFHVEEEGKGKKDGEKIKADPENVKKFREDLTALGTVYINDAFGTAHRAHSSMVGVQLPQRAAGFLMKKELEYFAKVLEHPERPFLAILGGAKVADKIQLIENMLDQVNTLIICGGMSFTFKKTLENVEIGTSLFDQEGSQKVQSLVEKAKKNNVKLVFPVDYVTADKFDKDAQVGEATDESGIPSEWMGLDAGPKSRELFAQTVSEAKTILWNGPAGVFEFPNFAKGSNALLDATIKAAKNGATVIVGGGDTATLVANAGKESELSHVSTGGGASLELLEGKTLPGVAELSEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I4X2</accession>
    <name>A0A1B9I4X2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_03900</name>
        <name evidence="3" type="ORF">I206_105191</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011794.1">
        <property type="nucleotide sequence ID" value="XM_019155640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I4X2"/>
    <dbReference type="STRING" id="1296096.A0A1B9I4X2"/>
    <dbReference type="GeneID" id="30172269"/>
    <dbReference type="KEGG" id="kpin:30172269"/>
    <dbReference type="OrthoDB" id="424465at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050910">
        <property type="entry name" value="JMJD6_ArgDemeth/LysHydrox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480:SF6">
        <property type="entry name" value="2-OXOGLUTARATE AND IRON-DEPENDENT OXYGENASE JMJD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480">
        <property type="entry name" value="ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="161"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF50575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC71238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="417" mass="48474" checksum="8281075FDB3A564F" modified="2016-11-02" version="1">MPNWAGISAKQQHEIDRLITSTPTRELPTYDNLSYQDFLSNHLIPNHPFLLSSFATSKWSSSHDFRLKNLDNSTALPNLSALRKYAHHVVPVANTLRQEFSEFERTEKALGEVLDLWDIDEGNGLYVKDWHLMAEIEKEGRGVKEVYQVSECLRDDWLNPPYTPDSRIITSETEVNSASTSDFRFTYLGPPLTYTPLHRDVYGSYSWSANIVGRKIWWLFPPDKLDKVKDEYGELVFDVRELQDEGGAIKILQQEGEIIFVPSGWHHQVVNLDFCISINHNFFSSPTLSRIYDTLCNSQERVEEAISDVKEMIIGRLGTSDNAWEKEWVEEVQGLLERDAGWNWKGFWTTIKQNVEMPPALDHLSPTIEMRNKWIYDIIERYETRRERIYLEEVQQIIADIKMVVGSFSNINTEHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I687</accession>
    <name>A0A1B9I687_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I206_03101</name>
        <name evidence="14" type="ORF">I206_102746</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF51036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012255.1">
        <property type="nucleotide sequence ID" value="XM_019154852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I687"/>
    <dbReference type="STRING" id="1296096.A0A1B9I687"/>
    <dbReference type="GeneID" id="30171470"/>
    <dbReference type="KEGG" id="kpin:30171470"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14127">
        <property type="entry name" value="STKc_CK1_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000160">
        <property type="entry name" value="Casein kinase I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="34"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="330"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="399"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="455"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="399"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="432"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCF51036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WWC68811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="502" mass="55081" checksum="CC64D6D36B2C9C28" modified="2016-11-02" version="1">MATTHVIGSSNPGAHLSSSGSHSSSSSNIVGVHYRVGKKIGEGSFGVIFEGTNLLNSQTVAIKFEPRKSDAPQLRDEYRSYKILSGCLGIPQVYYFGQEGLHNILVIDLLGPSLEDLFDMCGRKFSVKTCCMTAKQMLSRVQTIHEKNLIYRDIKPDNFLIGRPATKGANTIHVVDFGMAKQYRDPKTKQHIPYRERKSLSGTARYMSINTHLGREQSRRDDLEALGHVFFYFLRGGLPWQGLKAATNKQKYEKIGEKKQTTPIAELVEGYPNEFSIYLNYVRKLTFDETPDYDFLRGLFDLALQNIGDQDDGTYDWMMLNGGKGWEMNGRQSAAQAEVSRHNTRTRDREYRDRVDKLRNGSAAGGQQPSPLKQRKSGGAGSALPNASNQAIIGVSASSPLPQSRRQSQQGTNNPNSGSAHPFASANALHPGTNNDSYDPSNVAIQSQAGLQAISPMNVNGRPGNTAANSQQAGEGDYNTGGGRQDKGGNGFIRLLTCGCFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I6V8</accession>
    <name>A0A1B9I6V8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Taurine dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_03345</name>
        <name evidence="8" type="ORF">I206_102992</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF51278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC69056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012497.1">
        <property type="nucleotide sequence ID" value="XM_019155094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I6V8"/>
    <dbReference type="STRING" id="1296096.A0A1B9I6V8"/>
    <dbReference type="GeneID" id="30171714"/>
    <dbReference type="KEGG" id="kpin:30171714"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF10">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="6">
        <location>
            <begin position="55"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCF51278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC69056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="359" mass="40247" checksum="485F81578957AE8A" modified="2016-11-02" version="1">MPVAVQERNPIETIKSALSNVTVSETQEPVDLRSYSHFDATPSIGTEFRAYSPDGKPTLSVRDILGNAEREKALGRLVSERGVVFFRDAVISPEEQLKLVDALGKHGGKPSTSGLHVHPLTMGGSEFGDEVSVISNQFVFDNKYKRDDFTVLKRRFHADLWHSDITFEPVPSDYASLQIRELPKVGGDTLWASAYEAYDRLSPAYKTLLEGLTATHTGQGFIDIAKRNNVTFREPRGAPENVGQSLSTIHPVIRTNPVTGWKGLFVNRGFTKRINELTQHESDNLLDFLFEHISANHDLQVRFRWEENSLAIWDNRSTFHSATEDLDGDTRVGTRSVSLGEKPYLDPKSKGRREALLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I7C5</accession>
    <name>A0A1B9I7C5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_02128</name>
        <name evidence="3" type="ORF">I206_104594</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012633.1">
        <property type="nucleotide sequence ID" value="XM_019153893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I7C5"/>
    <dbReference type="GeneID" id="30170497"/>
    <dbReference type="KEGG" id="kpin:30170497"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF51414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC70643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="389" mass="43515" checksum="30DA74934D519709" modified="2016-11-02" version="1">MSTSSNIIPSCASAYGGQASSSIAEHNAERTRVMSSHSVTRQDIAKAFKRKSGLLEVDPHFCEFDISPLLTMYHQPSTTPAARTATIAAMFHTAMTNGLLLNTRRFRAKEALSKWNQEEEYRSSHQWQAVKHHFGLSGVNDEKALKVLRWQFKESANPKDPGSPSDYCKEMFTIDLTQHVCDTIYQGFPNSRAPSVLPKEALEECPETIHPWVRARWKSRSGIYHPDAYPKLRSNLLLVDSLTRGTLFSDWDHARDQDPDNWRRDDDQKNDAISPGGAQLPPHGNLPSANMSDMTISDGGLAHREEPETSNYLGSGEDWSPKDNKHNNFGPNDLNLDIKPSAPSHPARYPDPTTESTVTDREEIQNAAKSRLKRTKSPHATCFTSCCPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I7L4</accession>
    <name>A0A1B9I7L4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_02173</name>
        <name evidence="3" type="ORF">I206_104637</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012678.1">
        <property type="nucleotide sequence ID" value="XM_019153938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I7L4"/>
    <dbReference type="GeneID" id="30170542"/>
    <dbReference type="KEGG" id="kpin:30170542"/>
    <dbReference type="OrthoDB" id="10445700at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628397" evidence="1">
        <location>
            <begin position="24"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF51459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC70686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="149" mass="16379" checksum="1EFA3A04FD6A6513" modified="2016-11-02" version="1">MFSISSSTKLAALLAMLGNQVTANSAHAKYEIYPAQLSKLVDLTTNAPLAVPPAAYKFDAMNDRGSMTSKTFKWVALDENDDQKELWSIELTASPGYPWDENKAARYELKLDSPWATISDDYQAAHLASNGSSYICYFPPCADAPVFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I866</accession>
    <name>A0A1B9I866_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I206_02440</name>
        <name evidence="15" type="ORF">I206_104900</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012944.1">
        <property type="nucleotide sequence ID" value="XM_019154204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I866"/>
    <dbReference type="STRING" id="1296096.A0A1B9I866"/>
    <dbReference type="GeneID" id="30170809"/>
    <dbReference type="KEGG" id="kpin:30170809"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14125">
        <property type="entry name" value="STKc_CK1_delta_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000159">
        <property type="entry name" value="Casein kinase I hhp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="25"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="314"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCF51725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WWC70948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC71089.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">CBS 10737</strain>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
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    <dbReference type="KEGG" id="kpin:30169971"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC69455.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
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    </evidence>
    <sequence length="229" mass="25922" checksum="7F41D9892AF354A2" modified="2016-11-02" version="1">MIHQCLEHIDADFISHICHCIVQIPWSSCFPSSNFRNRPKSPDLEAQEGELETLLSGSNAGWDDSDMFSLSTPRAVKERQAKGLDPSKPMINPFKSHSTKADPPAYESHLNPSYSYSNPSSYPQRPVSGYSEFEIEIDEDAKSLSINPTKLAEIAKQFEPTLTLDDIRREEEEQAERDREAERVNGPSMRKDYARTGSCSRIGRINQDQDEEFGEFEEGKSNDAESESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IAB0</accession>
    <name>A0A1B9IAB0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    <gene>
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        <name evidence="3" type="ORF">I206_103169</name>
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    <organism evidence="2">
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        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Murphy C."/>
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                <person name="Roberts A."/>
                <person name="Saif S."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
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                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
        </source>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
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            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">CBS 10737</strain>
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    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">CBS 10737</strain>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A1B9IAV6"/>
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        <property type="component" value="Chromosome 4"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF52557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC69210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="36589" checksum="B4926C99F0B41E3D" modified="2016-11-02" version="1">MGVTMKVKSIRPTHNKKPSQEAISSRKLSTISENTVTSLNQPFQDDTADLVLISSDGLIFKVHHTKLNGCRIEFRNALFNNCLSTPPPSPVSTTTTTITTTTINLDLPEIHFLDPTIESSIILSLFLRLLYNLSLPIPNLPIYFQAYENLVKFIKRWECNFVCNDLSRSIRSWLEEGNISSSKVFKIGDSLNDIDLMRDALKKGGEYTWSGRLIEDPSKRKGRQMSRTSSFTNNQNSLSSLNASARAKPLQESISFDILRDGLPDQPSLDLTAVPYEYFISLSDEVKFALLRASRVGRDPNLDTDWEDVSVEFNHVLRDLRQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IB61</accession>
    <name>A0A1B9IB61_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_00203</name>
        <name evidence="6" type="ORF">I206_101123</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GcvT family. CAF17/IBA57 subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="OCF52902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC67216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014121.1">
        <property type="nucleotide sequence ID" value="XM_019151983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IB61"/>
    <dbReference type="STRING" id="1296096.A0A1B9IB61"/>
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    <dbReference type="KEGG" id="kpin:30168572"/>
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    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GCV_T_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045179">
        <property type="entry name" value="YgfZ/GcvT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602:SF0">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00093447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF52902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC67216.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IB65</accession>
    <name>A0A1B9IB65_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_00189</name>
        <name evidence="3" type="ORF">I206_101137</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF52888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014107.1">
        <property type="nucleotide sequence ID" value="XM_019151969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IB65"/>
    <dbReference type="GeneID" id="30168558"/>
    <dbReference type="KEGG" id="kpin:30168558"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF52888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC67230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="164" mass="18374" checksum="144DE2479BFFC02F" modified="2016-11-02" version="1">MPIPITRTKRHTPKFRPSYPKISKQIDIQVILERKMSAPPKIAFTDPFNGSTSVLIPPVDYISPSAFHTPKIEDSPTYKVDYVLPFHAVKHINDTKRSSQFMPTKEDNAALPVSRFSGEEDEEPLLSQEMDTYPIVGNEGSDAGFETSNLVNMADPLDGLGRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IBJ4</accession>
    <name>A0A1B9IBJ4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I206_00066</name>
        <name evidence="14" type="ORF">I206_101256</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
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        </source>
    </reference>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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        </source>
    </reference>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 10737</strain>
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    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">CBS 10737</strain>
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    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
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    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
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    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">CBS 10737</strain>
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    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014299.1">
        <property type="nucleotide sequence ID" value="XM_019152161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9ICH0"/>
    <dbReference type="STRING" id="1296096.A0A1B9ICH0"/>
    <dbReference type="GeneID" id="30168750"/>
    <dbReference type="KEGG" id="kpin:30168750"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF9">
        <property type="entry name" value="CRYPTOCHROME CIRCADIAN CLOCK 5 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="7">
        <location>
            <begin position="44"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="618"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="625"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="325"/>
            <end position="329"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="371"/>
            <end position="378"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="491"/>
            <end position="493"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="5">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="5">
        <location>
            <position position="478"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="5">
        <location>
            <position position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF53080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC67038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="651" mass="75760" checksum="03D187C8C9306E38" modified="2016-11-02" version="1">MKKSNSKSTKKPEIPLTSLIKPDLTSPKSLKSNSIGKEKEENKINVIYWHRTDLRLKDLPALNKLLNKNENEIKKINNFWPIWCFDPNYLYKHRVGLNRWNFLLESINNLSLEYKKLNKNQKLWVLRGKPFLIFKKLIKDWKITHIVWEKDSNAYSKIRDEKIITLAKELGVEIITTPGRHLYDPDEVIKANKGKPTMTLHQWQSITSKMKDIDKPFPAPESIPDPGPSDLKDHHEENWGEYEGIDLNADVRTGKDTCFDSLTGPSDDPFSVPTMEQLGFPPATTTIHGGTIEGYRRLKLFLSDPEKVSTFSKPHSAPTSLEPSTTLLSPYIKFGCIGIRELWWGCKEVVEKWRKNGGKGETKEPENMFGQLQFRDMYACAEAAIPNFERIRGNSICKYIDWSLQNQYDKNGNEILPRPKDEKDEQAEKRFEAWKKGETGFPWIDACMRQLKYEGWIHHLARHSVACFLTRGQCYISWERGMEVFDEWLIDWDPASNPGNWMWLSASAFYSQYFRVYGLVSWPQKTDKTGELVRKYCPELKDFPDKYIYCPHLAPLTIQEKSNCIIGKNYPFPILNEQLEKELCISKLKDSYKLNFNGNHLEVLNGNVNKKLKELHENNGNTHFKKSEENEKKRKAKGEGALDKFIKREKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9ICI4</accession>
    <name>A0A1B9ICI4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Capsular associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_00650</name>
        <name evidence="5" type="ORF">I206_100675</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014567.1">
        <property type="nucleotide sequence ID" value="XM_019152429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9ICI4"/>
    <dbReference type="STRING" id="1296096.A0A1B9ICI4"/>
    <dbReference type="GeneID" id="30169019"/>
    <dbReference type="KEGG" id="kpin:30169019"/>
    <dbReference type="OrthoDB" id="202415at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF35">
        <property type="entry name" value="PROTEIN O-GLUCOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="3">
        <location>
            <begin position="302"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF53348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC66770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="643" mass="73578" checksum="A17E7E1483C3DD0A" modified="2016-11-02" version="1">MAVPKGIASRNRVLALAGLLFSLLFLLHFLFPGSNKLLAHTQRWTTASSSVIRSKFLREKAKEPKSSIHHPIPKLMLDAKEEFEIKLKKQSKTLNEAIEEYKKRYKMNPPKGFDEWFEFAKKHNSIIIDEYDQLNKDLKPFWLFSGEELRRRCIQVGFLPSVDLVRIENGQTRTIDVSKGFDDSEVGARAKGFRVMLEKFQDKLPNMDFPINEKAEGRILVPWEENLFSNLTADSTKGIEHVLGGEFIPDWRGDGNVWEAYRRTCEPSSQARRLFGSLRSHLKEGQAPISRLADAGITSDTISEDFKFPSNVDDKFDFCDHPWAHYNQGHFFSDWRTIHALYPMFSPAKGVGYSDILIPSHYYFSSTKRYTYGWDPVNMVIKDVDEMETPWEEKSDDIFWRGATTGGGSSPPGFLAQYQRHRFIKMTSDTSDVNKTVVFADPPGTNNFVSAQVPIGQLNEDMMDVAFTKAVGCTQYPGGCDGMRKDHRFADAVPLGENWRHKYLIDVDGMGYSARLFALLKSESAVLKSTVYTEFMSEWLQPWLHYIPISQLYQELYNVHAFFSGPSEAMLDASNATRGTYQAPGLTTKRLDGDAELRKIAKAGRDWMFTIGRKIDMEIYVYRLCLEWGRLTADDREAMTLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9ICJ8</accession>
    <name>A0A1B9ICJ8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CENP-C homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_00670</name>
        <name evidence="10" type="ORF">I206_100655</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CENP-C/MIF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014587.1">
        <property type="nucleotide sequence ID" value="XM_019152449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9ICJ8"/>
    <dbReference type="STRING" id="1296096.A0A1B9ICJ8"/>
    <dbReference type="GeneID" id="30169039"/>
    <dbReference type="KEGG" id="kpin:30169039"/>
    <dbReference type="OrthoDB" id="1939643at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019237">
        <property type="term" value="F:centromeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051455">
        <property type="term" value="P:spindle attachment to meiosis I kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06993">
        <property type="entry name" value="cupin_CENP-C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000033">
        <property type="entry name" value="Centromere protein C 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028386">
        <property type="entry name" value="CENP-C/Mif2/cnp3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025974">
        <property type="entry name" value="Mif2/CENP-C_cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16684">
        <property type="entry name" value="CENTROMERE PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16684:SF11">
        <property type="entry name" value="CENTROMERE PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11699">
        <property type="entry name" value="CENP-C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mif2/CENP-C cupin" evidence="8">
        <location>
            <begin position="609"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="67"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="513"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="703"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="208"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="397"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="427"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="524"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="547"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="712"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="725"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00057947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00075033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCF53368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC66750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="759" mass="83257" checksum="02C043ECDD822E65" modified="2016-11-02" version="1">MASRTPGRTRRGEEKHVPYNDDPKMVGTRSNAPMPTNVARLHDGFEDPAEFFQSPGTDVGSRTISSVFARTPKTPGARSDYTVQTPMTGDTIGTMRKSKGRRSEFGNASDDEAEEELDGLLGRDDLLDDEDDLNPATPKYHNSSNPPSVTLPSRSRISVSSPGLNRSFDAIPSPRASNSAARSSPRKSALSRIIPSKATRGGRTSDLTDGDIGADDTQELDAGFDADLGSSPLKNTTSRLSARLSNSPTNAKKQSPSQKKRTGTTRRETIPDSYPEESVAGDVSFGDDLQEETSARRKSTKIGTNSKASNLTREDEDDASQQSASDNDGPSYDNDGGMEGFDDTAQDISLGNNYAENEDNGGDVTALVDDMAGDNGLEDVEEEDEEDLDLEQDAIDTENRSGEETERPKKSTKRPPVAKTKKSAPRQAREDSARSRTIRTREGSVVAKPKRTRISQVGIVDEEDEEEDGYHGTFKTRRSTRTHYAPLDWWRNERVEYARGPGLPVIKAIVTMEKEEPQPLSKVGRARSVAKARQRSVSESKRKRYQDDDDDEEGYQPEPADEDGWDANTDSTGLVKDYPSGAEATRIIACPKSMLKPKDQKTKDESQTFRYQKIFGEGNFMAAGVVHIGVGKSKAPKPSKDNAYVFYVIQGAVQVQIYRTSFVMAPGGQFLVPRGNDYSIENISPDKEAQLFFAQARKIRADEEETEDQHSILINGNRSLSIPASSSKNKSVNQLKKKKKLSTRVRDESGTGSGDGDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9ICM0</accession>
    <name>A0A1B9ICM0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_00664</name>
        <name evidence="3" type="ORF">I206_100661</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
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                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 10737</strain>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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</entry>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">CBS 10737</strain>
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    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="7">CBS 10737</strain>
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    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="6">CBS 10737</strain>
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    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
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                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </evidence>
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    </evidence>
    <sequence length="255" mass="27402" checksum="6A490206BF5F922C" modified="2016-11-02" version="1">MGRVIRAQRKSGGIFKSHTHHNKNPARLRNLDFAEKNGYIRGVVREIIHDAGRGAPLATVVFRDPYRYKLRKETFLATEGISTGSFIYAGKKATLNVGNVLPISQCPEGTIISNVEEKIGDRGALARTSGNYATVIGHSETGVTRIRLPSGAKKTVSSRCRATVGIIAGGGRIDKPFLKAGRKHHAMRAKRNSWPRTRGVAMNPVDHPHGGGNHQHIGHASTMARDAPSGQKAGLIAARRTGLLRGTAGKTVDTA</sequence>
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<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019152285.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="30168874"/>
    <dbReference type="KEGG" id="kpin:30168874"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC66915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="115" mass="12922" checksum="72E07FCC91B6DB7A" modified="2016-11-02" version="1">MEESWNEYSKKSGRQEWEVTDISTKTDGRDSEHPNLSVDHYGNGAASQHGYTMCERVLNHVGDEKIHDHFAVAGGVKPWGYWEKVDKGSTEDEMPACQLSYSIVNGGKFIAPDEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9ICT6</accession>
    <name>A0A1B9ICT6_9TREE</name>
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        <recommendedName>
            <fullName evidence="8">VASt domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="9" type="ORF">I206_00648</name>
        <name evidence="10" type="ORF">I206_100677</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YSP2 family.</text>
    </comment>
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        <property type="protein sequence ID" value="OCF53346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC66772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_019152427.1"/>
    </dbReference>
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    <dbReference type="STRING" id="1296096.A0A1B9ICT6"/>
    <dbReference type="GeneID" id="30169017"/>
    <dbReference type="KEGG" id="kpin:30169017"/>
    <dbReference type="OrthoDB" id="2162691at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:endoplasmic reticulum membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum-plasma membrane contact site"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120015">
        <property type="term" value="F:sterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13220">
        <property type="entry name" value="PH-GRAM_GRAMDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051482">
        <property type="entry name" value="Cholesterol_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319:SF4">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="794"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="domain" description="VASt" evidence="8">
        <location>
            <begin position="531"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="303"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
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            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
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            <begin position="154"/>
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        </location>
    </feature>
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        <location>
            <begin position="177"/>
            <end position="193"/>
        </location>
    </feature>
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        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
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            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCF53346.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="914" mass="100400" checksum="00983679D6DD1446" modified="2016-11-02" version="1">MPSILSRFKRSPSTSSTTSESDLFAEALERDRKNRRVSSVSSTSYTLPEGEEDLSYNDSPRPGKGGSLFVENFDNSSSIGGSPIKRQITPSPRNKPVPLSLPIPNSESKSNQPLGTPKLVLTEEGSNSPRSFSSSPVVTSPISRNKANRPNLRLGSSNTSQGISEDELETPTAYDHSFNSPISRMSLPVTTDSPNRDRSGSIISSTGGGRSRRGSILSRHTNKDMISPPLSPNALQPIDSRQTSGSKKSSRKKKRSKSINSTSGQSGIAAALAKGGLHLPGTGQGQVTPEDIINSLKNKKRSLQKRSPFLTSSKDNHDDYSLNGEEYDGEDGAGFDDDFDDDDDSDSDLDDDLPVTGFAVASNRRNADFHALFPSIDDGDYLIEDYGCALSKDILLQGRLYVSENHLCFHANILGWVTDVVVAFADIKTIEKKMTALVIPNAIQVSTGNAKYTFASLIARDSTYDVMMNIWRLCNPNAVMSSISLGGTNILGSRPGSVAGDEVEAPVSGGAARGSKGHAPTQCACGKEARHYNETALDTTFHSTPEKIYELMFNSGWFKNFLSENQKLRDIECSEWRPISPENPLLTRSSSYIKPLNGSIGPKQTKCHIVDEHDHLNYDDYISLITTTRTPDVPSGGVFSVKTRTCLMWAGKNSTKVIVTTTVEWTGKSWVKGIIEKSAIEGQKQYHDDLEQGMRQYIKENPGEFAGIGGGSDDDEIELNQIENEKLEEKENKSEAQVYADQTRKKRQEEDMGLLQYSFDTLISGLKSIFSGIKGIFESLNDLLIDTPFKIQNLMGIIIILLIISNIYTFLNIDKSAKKERRYKKLGSESGSGSGFKSGKVMKNDDFDSDFFEKAIKRILYEQQSINSDPIEEIKNLLNNLDNIESRVGKLRDSIVKIKADVGGNNNKKLDNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9ICW5</accession>
    <name>A0A1B9ICW5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_00678</name>
        <name evidence="3" type="ORF">I206_100647</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Abouelleil A."/>
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                <person name="Berlin A.M."/>
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                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
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                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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            <authorList>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
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            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
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        </source>
    </reference>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
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                <person name="Young S.K."/>
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                <person name="Gargeya S."/>
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                <person name="Berlin A.M."/>
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                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">CBS 10737</strain>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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                <person name="Birren B."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="EMBL" id="OCF53254.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC66865.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Abouelleil A."/>
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    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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    <dbReference type="PANTHER" id="PTHR16184">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184:SF6">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF53396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC66722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="30184" checksum="9A3319D3E58AD9E3" modified="2016-11-02" version="1">MTYLTPHLPFPSSSSSLPPSNSHLIISDTVASPSHFALFHLVSSALGKEKRKVIWVDFRGEGRASWEAILKKVGTPLPPLTSPQFIHITPSSLPSFIGPSSSLKNAPRLFDDNDRPSLKTTYNSILPHISENSLVILDGLTELNWIGFSSLEISKFVRAVFSKVKSIKAILVSTLHADHLPLSSSIIPQTEQGDDEILQRLLRIGQGCWWRVSHLASGRSADVMGEISSHPLSKPIGLDESEKFPHIPRSNPLQYRLEPNTVRVFAKGTGRGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IDH2</accession>
    <name>A0A1B9IDH2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Formate dehydrogenase</fullName>
            <shortName evidence="5">FDH</shortName>
            <ecNumber evidence="2 5">1.17.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NAD-dependent formate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_00975</name>
        <name evidence="10" type="ORF">I206_100350</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>formate + NAD(+) = CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:15985"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.9" evidence="2 5"/>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014888.1">
        <property type="nucleotide sequence ID" value="XM_019152750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IDH2"/>
    <dbReference type="STRING" id="1296096.A0A1B9IDH2"/>
    <dbReference type="GeneID" id="30169344"/>
    <dbReference type="KEGG" id="kpin:30169344"/>
    <dbReference type="OrthoDB" id="418179at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042183">
        <property type="term" value="P:formate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05302">
        <property type="entry name" value="FDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000057">
        <property type="entry name" value="Formate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03210">
        <property type="entry name" value="Formate_dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033689">
        <property type="entry name" value="FDH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005750">
        <property type="entry name" value="PRK07574.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938:SF9">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="7">
        <location>
            <begin position="76"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="8">
        <location>
            <begin position="169"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="214"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="269"/>
            <end position="273"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="350"/>
            <end position="353"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="5">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="5">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCF53669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC66448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="413" mass="45628" checksum="43EE322BDB0C378D" modified="2016-11-02" version="1">MSSLLRSRLISSKNILRNINYTRQFSSTSSNMVKVLADLKLFLKVLAVLYKGGQAAQEEPRLLGTIENSLGISDWLKKEGHEFIVTDDKEGPNSEFQKHIADAEILVTTPFHPGYLTADLIDKAKNLKLCVTAGVGSDHIDLNAANKKNITVAEVSGSNVVSVAEHVVMSILLLVRNFVPAHEQIVSDDWNVAEIARNAFDLEGKTIGTVGCGRIGYRVLERLQGFNCKELLWFDYTDLPEDKKKEEFKRVEKLEDMLAKCDVVTINCPLHEKTKGLFNDEMISKMKKGAWLVNTARGAICDRDAVKKALESGHLNGYAGDVWDVQPSPKDHPWRHAFNTLGGGNGMVPHYSGTTLDAQARYANGAKDIIQRYFAGKEQEPANLIVVNGDYASKAYGQRDNKNKATGQKPAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IDN5</accession>
    <name>A0A1B9IDN5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_00949</name>
        <name evidence="3" type="ORF">I206_100376</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014862.1">
        <property type="nucleotide sequence ID" value="XM_019152724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IDN5"/>
    <dbReference type="GeneID" id="30169318"/>
    <dbReference type="KEGG" id="kpin:30169318"/>
    <dbReference type="OrthoDB" id="2596859at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="798"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="808"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="848"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF53643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC66474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="988" mass="109414" checksum="D616F7B2C15BB054" modified="2016-11-02" version="1">MDTCALNMIPQAGNSSTSIVLGPPITPTTKMSAIPLEDNDFGLDDIRQFTPKPLNRSLPSAPPESSRTVRRSLDSSYSCHSTFSSHTNSYSNRTPPSHQRSASLSRESSYTSCNPNTEDDNRCRVSFDATPVQPSVAAFPSNYRQNSHSRRMSGGSFGQVQDENQERNDQEEADKQINFKKARFLEAPLISRSNLSASSDIRRSYMSAFNGEEEPELYAEEFRIPVDENIRSIPGVVGLGEGWAGGPQSKPKKKWYSRRTTVEEDPLSLWNEDKVISPNTSPLKGLWSKSKRNLFGQSSPALLDSTQGSEPPRSLSRIGRLFSMSRPNLTTTDQSPSGPRASSKPMKDMSKRSSLGIFSSSEITLHPNIPSTVIPSSPSMPILALAEPTTPIPRRHRQYSRSTLARSEGDSNSITDAIPIEASSPKRNSLRPPWRPSSMVITNRHSALVAADEGMGTSGSSTSIETPKSRESSCSPSSRGLALTRTATFGLNDIAAEQRIDEENASIEQELDDEWVQVRKGSSSSGLDSDKNKPLPRVPSPYRRPTTKQRKDSWLKRVKSALTASTSSSELSTLSETVDRLLPRRKSAKARKGSSEDYVADPIWCEPRMEPLKTSPIVPQRKSSRRSRRSSWMLRSSSSLSKRLSRLTEHEEGDDDRDLDIEEVDHANRLTASMDCRNLQENIERLDRQTPKRGKSFLGRRRSSNFSLLGIKSRRSSSVHPLDNVDGLPASVSMPTLSKLTAIDLNLHVDITGEGLGLEDILDEERRGSIVHSLGCMTPNLNNTREEVIQSTFDTLSAKSPDIKPKNHVNQGSPTTSSYRSKMKMRHNSLPLSTTTENHTRHRRTTTVSTINSSPSPSLITPRHPAELATFLNALTFMDADNGNEQERLENEIDLPTKANTKVGSAFDHNVVNDNLLHLPKSRKFSASTHRLSAESYLTQTSLYDTEEVVHGQAIRVESIGHFHKQASVISLEELGKNWSGGLQMTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IDT2</accession>
    <name>A0A1B9IDT2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">40S ribosomal protein S29</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_00889</name>
        <name evidence="8" type="ORF">I206_100438</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014803.1">
        <property type="nucleotide sequence ID" value="XM_019152665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IDT2"/>
    <dbReference type="STRING" id="1296096.A0A1B9IDT2"/>
    <dbReference type="GeneID" id="30169258"/>
    <dbReference type="KEGG" id="kpin:30169258"/>
    <dbReference type="OrthoDB" id="2565333at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.830.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="entry name" value="30s Ribosomal Protein S14, Chain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_uS14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_uS14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039744">
        <property type="entry name" value="RIbosomal_uS14_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_uS14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004424">
        <property type="entry name" value="PRK05766.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12010">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12010:SF2">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCF53584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC66535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="629" mass="72899" checksum="7C7BF857D6B9A0F9" modified="2016-11-02" version="1">MFPQRYQATKTIPDASSSSSSKKRLSSFSSSSTLIDSKPNPHLKFEDIHKIEILHQICAFEHIFQEFFAILDELIKPAIRATFKIHYNRQQLFINPFTKTIAKRIDNETELKYMTRRITDSQRQFKGNLVPEYWLKKIEKNFLSALSNTQIHLRSILEFDNQVGLFTRPMLKKSEISLKGIEFVLFSFPDGVDDPKELGFNDALTFTYEQFDHKDVLALGLGMARAINHRCNANIYWKFPTQLTEIKNTSIKGILCSIGKLRILDNHLQPDQQLFAFYSEKFGMLMEISTINENQRWHLHSRESSPSPRLPSLLPEAGLELHSSSDSTEIRTPPHIPDSKAYHCDVYTRKSSRKVASISDYKQQSFNLPREVIHRKSIAQRIYLDPDTDEDPEESSTLSVSYPIPLSNLPISKKRSRVISSPESDLAEIRDVQFRSTTQDQSNAAVIDTRKGYSFDEPITIDIDYIEYEEDITNIQSSSNSLLAAVVDEVIDQSSKHISNEVRYTSCSYTKSNSPGFLVDETAITTLQVSERDVKICKRYMPDLKNRLKRFERAVEGFKRDKKRYQEWDDRWKRAHSNVWFSRPRNYGKGSRQCRVCAHQAGLIRKWGLDMCRQCFREKSKQIGFYKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IDU4</accession>
    <name>A0A1B9IDU4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Leucine repeat containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_01185</name>
        <name evidence="5" type="ORF">I206_100142</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
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                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="Zeng Q."/>
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                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
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                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Roberts A."/>
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                <person name="Shea T."/>
                <person name="Sykes S."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF53470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC66648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="335" mass="36146" checksum="EC54729273721023" modified="2016-11-02" version="1">MTTAGPSIQRHSHSPHPHPIQTYQQQYRHHPYAPPNLKNTSSSSRSSQQRSSPNANGELPPSPPRSRRDASETPSIGLGVAFGGSSGGKWWDEELPPPPASLSSILDSFRKSGEGDRELLLAILGAKKAEEERLSALIQTRLTILQARLSLHSTAASLSSSPSPPVPVLENGTILNSSNVQSNNEIPLLVERTPSLTSSRGEGSSSSGMPSPPLPNQTGYVQPPPSVQINGNGNEKEQSHSIGGRGYWQLPSLQSSIRGPNNIQNRSPNGINERVLPLAPIREVRIEDRRFNVERNNSGSISPKSNESDSKRSSSGLEMLLDAGRVVNESSERDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IE32</accession>
    <name>A0A1B9IE32_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_00990</name>
        <name evidence="3" type="ORF">I206_100335</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC66433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="kpin:30169359"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051908">
        <property type="entry name" value="Ribosomal_N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43441:SF5">
        <property type="entry name" value="FAMILY ACETYLTRANSFERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43441">
        <property type="entry name" value="RIBOSOMAL-PROTEIN-SERINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="43"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF53684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC66433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="259" mass="29732" checksum="48FF3E5C65B715C0" modified="2016-11-02" version="1">MTAYLNTYSPKKVDVPRDIHLHTPPEEYDYNFCFEVKELQSDRVQLRPFVPSLHAQLFIDGLQKCGPDFTAWLIDWHSLEDVLVWQETVIRSQPSAMTYAIYTAPPASDEIVDPKNYEFAGMISMINSDVANMSSEPGWVCVLEKFQRTHVLTHAAGLIIHRILDMPSEGGLGLRRCQWFTTTLNEKSKAAALRLGFKLDGILRTHRVLAKGKKGVRPGRKGDYQEDQMTRDSWLASIGWDQWEEGIREHVDKLMARRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8KZC2</accession>
    <name>A0AAJ8KZC2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_100385</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family. ADAT3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_070202182.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="30169308"/>
    <dbReference type="KEGG" id="kpin:30169308"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chromosome 1, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF156">
        <property type="entry name" value="INACTIVE TRNA-SPECIFIC ADENOSINE DEAMINASE-LIKE PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SET" evidence="4">
        <location>
            <begin position="75"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="5">
        <location>
            <begin position="545"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="41"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="285"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC66483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="687" mass="76861" checksum="68FCE5475DA0DAF8" modified="2024-07-24" version="1">MENHQNDLSDFSQVGTSKLSLGSQLNDQIYHTQAVEGIKVSNENTAQNNKASKTNNKNNHNDESSNSLPHPINPLKLHLVSHPLRGRGVFTPFTIPAGTIIEESPVLVISQKEWEEGNMNESILGSYGFCWKDGGMGIGLGLASLFNHSASPNVNFIRSYSTSTIKFITSKRIEKDEELCICYSADESKLWFVKSDSDKQEGIDMGSSSDEEDGGFSKLNIGEEDLIDENNLKLKKERERRLKASLSKDINGKVKKHGKSLTSDNVQIQSPQPIKFNAAAGPSSITLSADSSRTSTPSSSSTSLYPEASSGFITSLPPPLHSGRDRSKRSTEAIELTQELDWDEEFWTGQNPSGTEREDEVAEYIREKGPAEKEAEEGADETMDIWALEFTDPRLTRNALDFSKDLTASDERLRHLKRVCRRKENNQEICRVVLAMVAEYDSSALQSIMTSYSSTLSHLIPVIHRVPSTIATTQEQLKIKSHLWPVSFSPAPIIPNDSSDWPIGRKAWVTSGIKRVIQIALEAKSKGELPIGTYCAALPKTFWPKKEEGFIQPTEELRASSYDTRQSENHPLRHSALNCIKSIANLRTVEPFISITPERNGSDYLLTSLTLFITHEPCVMCCMALLHSRVREVFYIFPRKKGGGFNGSELGIHARKDLNHRFEAWRYDGIIEDDVRQQLEVEEEIQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L0L6</accession>
    <name>A0AAJ8L0L6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Allantoate permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_101080</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058428.1">
        <property type="nucleotide sequence ID" value="XM_070202327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L0L6"/>
    <dbReference type="GeneID" id="30168616"/>
    <dbReference type="KEGG" id="kpin:30168616"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF41">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC67173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="516" mass="57751" checksum="B42991512119FC8E" modified="2024-07-24" version="1">MQDQDEKGFVPNTEQSVVVPDEHHRQVDTKQDDEAAGFLAEVASRPDAEEILAPFTPSESKKLLRKIDAIIIPLLFVALMMGSVDKVSLATSAVMGFRTDTHLVGQQYSWTSSIIYFGAIAAIIPSLMAMQRLPPHIYISFNVSVWGIITLCLPACKTFAQVMVVRTLLGVFESVIFAGFGLIVSMWWTREEQPLRTAIIFSTASSITNGLLAVAAWNYKGTRISKWQLLFLLVGGITFTWSLLLWAFLPANPTKARWLTLRQKVGATRRMQDNHTGMENKQFKLSQFKEAFIDPKTWFYFFTNVLLNIPNGGLVGFNSIVVKSLGFTTQQTLFLGILTGVFSWISSFFWGWVAVKTGRRHLAAMGSCVLPLIGTILLYKLPRNQVALLYLYLGYMYWGPYIVMMGSMYANTGGYTKKMTVYALGYIGYCVGNIIGPQTFLAKQAPLYVGGVVAMLVCYSLAIVVIGLFYLYLLRLNVKKAAEYEANKATLEAEDQLLSDWQDLTDLQNPRFVYAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L180</accession>
    <name>A0AAJ8L180_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Calpain catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_102628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058698.1">
        <property type="nucleotide sequence ID" value="XM_070202597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L180"/>
    <dbReference type="GeneID" id="30171350"/>
    <dbReference type="KEGG" id="kpin:30171350"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042498996" description="Calpain catalytic domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC68694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="31176" checksum="F6221407684AC7C8" modified="2024-07-24" version="1">MLNSLLYLLPLLGLGLTVIPLGSASPIDSGMSATEQIVKRDDHPLWLLQPKPVDILADKFKDDWLLAAAAALANTYPEKIQVLFSNVTDTKSETDNVDETMVKVWNNEEWQKWNNLPDDQKGGGPSSKEHKVVYSNITADYSGANQYWWIAALENAFIQEGGYDGITSNGFVKGDPHIALKMMTGLSAKLYNANNTQKNDLWYELRKSARRPTCVKIQWPEDADNDNENLWNAVLRVEPKGEYGTVYMFNSKIASEAAIEFEDLVEGIKYYVHQEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L1S8</accession>
    <name>A0AAJ8L1S8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="10">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I206_101716</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="10"/>
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        <property type="protein sequence ID" value="WWC67803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_070202446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L1S8"/>
    <dbReference type="GeneID" id="30174686"/>
    <dbReference type="KEGG" id="kpin:30174686"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:3'-5' DNA helicase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
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        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
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        <property type="entry name" value="Helicase_ATP-bd"/>
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    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
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    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF105">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
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    </dbReference>
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        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="206"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="438"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="775"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="905"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="787"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="832"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="852"/>
            <end position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
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            <dbReference type="ARBA" id="ARBA00022723"/>
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        </source>
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        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="942" mass="103966" checksum="42A74B45F182BAEB" modified="2024-07-24" version="1">MSGFRLYSDRLTLPSGNARASSSRHLTSSRSPPANDVQASASRRVSQEVAILVDSDEDDLPVAQTKPSHYFNASHKTASHQTESSNGHGSKPLHHKIGSMDLDAKEALKVALAKLDKEIKDVEAQLRPLQELHTSLNAERRSLETQLSKSVNISRPANDNTTVGTSIQQGTTNYHTTSFVFSPQILQKLKSTFGLNSFRLCQEGVINAAMDGRDIVCVMPTGGGKSLTYQLPAVMGSGLTVVISPLLALIWDQVRALKEIGVECVMMTGATSTSEQNTIYERMKNGASRGEKEIRLCYVTPEKVSKSKRLISTLEKVNENGRLRRFVIGKLKIMDCTTYMLTSYIDEAHCCSQLGHDFRPDYKKLSMLKTLFPRVPIQAVTATLSSKTLPDLLKILRLGPITDGNSAKSSGTVFFSAPLFRPNLHYKVLPKPSNAKMAISAMGQWIQDNHPGQSGIIYCLSKKDAETVADELRDWSNGDIKTGVYHAGIEDYEKERIHVKWREGRINVICATIAFGLGIDKGDVRYMSKSLEGYYQETGRAGRDGANSDCVLFYRGQDAARLSSLTYADVEGSGKLQEMLKFAQDLKTCRKVAFAKYFSASAHLSASAWDAPDTLSSSSGTTSTCGICDNCTRNPGSIISKDVTIEAWKILKVTRAVQTEQGRVTLTNLSDLARGLGGGMFNVIGGEGRKGKRKANGEKEKFDINSIGGKIALGKDDTETLIIHLLLLGYLQDYNVNVYIIPSDTAFRLTRLRLEDIEDRPPVKIECIFPAPKVKKTKTKRGKEGDGADEDDKEVSEADVEDDEGEGDGEHEEKRNSTKQGKKGTSDPPPKSKPKAKGKGKSRKKDEDEEEPVQREWFDIDFSDKKIKKDPIKPKNSARATPKGRTAKHSNPKQEEEEVIVIEDDLDDLQPDLRGSVTPRDQSIEVEDEEEMWAQIMNGDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L2I6</accession>
    <name>A0AAJ8L2I6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_103323</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_070202724.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="30170040"/>
    <dbReference type="KEGG" id="kpin:30170040"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035516">
        <property type="term" value="F:broad specificity oxidative DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051747">
        <property type="term" value="F:cytosine C-5 DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032852">
        <property type="entry name" value="ALKBH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31573">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31573:SF1">
        <property type="entry name" value="DNA OXIDATIVE DEMETHYLASE ALKBH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="244"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR632852-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC69384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="389" mass="44367" checksum="B7AA5E80015A2F32" modified="2024-07-24" version="1">MKRSLGSSTELSSPRASKRQASLAGFLQPKLKNGTSPKKVKLEEGKEGKPIIIDIDDETQSVFENVNKPLMDKGKGKAIEIESEIQNIKAGGGEEEEDGKSTDENLDTSWPPKDHPYHPPPSSNYNHPILIGSIPNTLKPIHFIIKPKIINNPITDLDLIYYKSFINPKLSSNLLMNYLLENLPWYRVKYMVRGMNINTPRYTTVFGKDSTLTPWNGYQKCNPRAIPEILERLMRKVEQITQSQFNFCLVNYYSSGDDSISYHSDSESFLGLNPTIASLTLGQSRDFLLRHINFKNHPKTGKEIKIEKFNLQDGDLLIMKGKTQHEWQHSIPKRKNLNKGRINITFRKGIIKYSTENYYNYNVGKGNLYKWDSKKKVMVESLPSDGGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L4A6</accession>
    <name>A0AAJ8L4A6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_102591</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058692.1">
        <property type="nucleotide sequence ID" value="XM_070202591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L4A6"/>
    <dbReference type="GeneID" id="30171314"/>
    <dbReference type="KEGG" id="kpin:30171314"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01857">
        <property type="entry name" value="HSR1_MMR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043358">
        <property type="entry name" value="GNL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709:SF2">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="420"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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            <begin position="260"/>
            <end position="361"/>
        </location>
    </feature>
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        <location>
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            <end position="674"/>
        </location>
    </feature>
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        <location>
            <begin position="720"/>
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        </location>
    </feature>
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            <begin position="274"/>
            <end position="316"/>
        </location>
    </feature>
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            <end position="349"/>
        </location>
    </feature>
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            <end position="361"/>
        </location>
    </feature>
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        <location>
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            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="748"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC68660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="766" mass="85516" checksum="808149D04D7A6851" modified="2024-07-24" version="1">MPPRTKAQSSGLGKALINRKAKEAVAPQESQLYTLDESNPLASVTHERDLDNFLANAALADHDFTTERSKLRIISAPNMPAPETNPFLLTAQQEKEVVKKKVELANELTVPRRPPWTRKMTRLELEKQERDSFVEWRRDLAQLAERSELLMTPFERNIQLWRQLWRVLERSHLIVQIVDARNPLGFRCADLEDYVQEIGSDEKDEEITVPGKGKRKSLLLINKADLLTYDQRCQWAEYFENNNISYAFFSAANAAALQEQAERQRQRQAGEYPSQEEEETNGEDEEAVVSGEEVEPQSEDEDDVDEEDEEGVEDDLAEKVAQTNLDGEYEEGWSTEGEDEDDDQPEGEVEERLADGQKMPLKDVARKIAAKFGSPPEGEEESIRTRVLSVTELEDLFMNSAPNIKEFATPQNPEPTKLMVGLVGYPNVGKSSTINALLGAKKVSVSATPGKTKHFQTLVLSDTVTLCDCPGLVFPQFANTQADMVVDGILPIDQMREYSAPADLICKRIPRDILEGTYGIRIDVREVEDGGTGQVGWEEFLSTYAIARGMTRSSFGMPDTSRAARVVFKDYVNAKLLYCHPPPGIDSDEFMESSRQITLAQLEEAYENGRKRAPVSHVSKNADTYVKPAGSGLSVPSQDVEEGEVEGESSNKGRERQLTTKQIKANAASAPMRSNKEKMTALDNVYFNEAGSQPRLVVKGRNLKLDVPDIATGQSFARSQQFPHQRMLGPDGMPVIGGNPKEVGGSNGKKHFKRKEGKKRSGRGYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L4T8</accession>
    <name>A0AAJ8L4T8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I206_102851</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058737.1">
        <property type="nucleotide sequence ID" value="XM_070202636.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30171572"/>
    <dbReference type="KEGG" id="kpin:30171572"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054295">
        <property type="entry name" value="CHS4-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF16">
        <property type="entry name" value="CHITIN SYNTHASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22997">
        <property type="entry name" value="CHS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="470"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1045"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1075"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1100"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase 4-like" evidence="13">
        <location>
            <begin position="390"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="594"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1196"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1250"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1303"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="155"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="599"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="626"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1196"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1349"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1361"/>
            <end position="1370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WWC68915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1385" mass="153753" checksum="D3E6005DD80DA7FA" modified="2024-07-24" version="1">MSRPSNNQNVSFKDDVHPSRRAQRDDQPPRPPAKNLPSKNSLTTTVSGSSSGYNAEALGYDNDGYVDAAQGFSASNDADIRRKKSLIRPERERIDPGHRLWHYREHAAEDQVDVQPSCANLRRGKSLLARDTDEIDHQSGLNIFKRGATIRRRASQATPRQPPNGAQSNRAGHANRESEEKFGCLGNFAPGPKDAWMVYCYLLTFLVPGFVLRNVFGKRTPEAQRAWREKMGIVGIVAALMAIVGFVTFGFTQTVCGNTELRIAGGTADNASLIINGYDYDLGNWKHPAAGSTFNGSTSPLYMDQYMAGGKDVSFMFQNVNRHCLGVITPAAGTGITHNGNQMAWYFPCNIHDQNGTSAVNLTGYSDANNCHTTTTARSSFAALPPTAEIYYTWNRVANESRNLAVYKSSQVSYPSFFDTVKQRNETFAGKDITAFVQRNGLEQYAQCMTDIIQVGFVDSISIGCVASDIVLYVSLVFILGAVMIKFGMAVVFGWFLSWRLGNFEGESYQQRMKRAAEIENWTDDIYKAAPGYLRPNAANKGGSGGGNARKTVFLPTTSRFSKAEPMLVSSSRPSTAYGLADSRRQAASVYGGKLAPGMQTTPPGSPMLRNSRSSTSLPFRDDSHQSLSDQSMNNNNPTNCPFPLGNVVPQPAPDFEPFRFPLVQSICLVTAYSESIEGLRTTLDSLATTDYPNSHKLILVICDGMVRGSGSKQYTPDIVLGMMKELVVPPEEVEAHSYVAIADGHKRHNMAKVYSGFYDYDSETVEPSKQQRVPMVLVAKTGNPLEANDAKPGNRGKRDSQIVLMSFLQKVMFDERMTTFEYEFFNSIWRCTGIPPDRYETVLCVDADTKVFPDSLTRMNACMVNDHEIMGLCGETKIANKSETWVTMIQVFEYYISHHLTKAFESVFGGVTCLPGCFSMYRIKAPKGDRGYWVPILANPDICEHYSENVVDTLHKKNLLLLGEDRYLSTLMLKTFPKRKMIFCPQAVCKTIVPDTFRILLSQRRRWINSTVHNLFELMLVRDLCGTFCFSMQFVVFMDLIGTLVLPAAISFTLYIIIIAIIPESVTHMPRPTVSLILLAFILGLPGVLIVITSRKVAYVGWMLMYLVSLPIWNLVLPAYSYWHMDDFSWGETRKVVGETKEASHGDKEGTFDSSHIVMKRWVEFERERRWRNGTESRDSQYYDVVQRANSPKGYSVVSTSETSYSGFGGTNEGNPLFRQSQSFQSMSQMVPSPEGNPASVSQLALPPARGASLGRDHSSGSAESSGSNTLERANSDDPSYGYHAYPNESYQDDAEQPILPANYLPQPISHPVHVEPERTRRPSQRGVSLVDTGPVRQQVAPHDAVRRVSRHQRRSSSRNQLVSPISSNGGHGTLPPGAAPPSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L4Z5</accession>
    <name>A0AAJ8L4Z5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_103631</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013301.2">
        <property type="nucleotide sequence ID" value="XM_019153140.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L4Z5"/>
    <dbReference type="GeneID" id="30169736"/>
    <dbReference type="KEGG" id="kpin:30169736"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000024">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00250">
        <property type="entry name" value="RNApol_arch_Rpo10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023580">
        <property type="entry name" value="RNA_pol_su_RPB10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020789">
        <property type="entry name" value="RNA_pol_suN_Zn-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000268">
        <property type="entry name" value="RPABC5/Rpb10"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003089">
        <property type="entry name" value="PRK04016.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431:SF3">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01194">
        <property type="entry name" value="RNA_pol_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005653">
        <property type="entry name" value="RNA_pol_N/8_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46924">
        <property type="entry name" value="RNA polymerase subunit RPB10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01112">
        <property type="entry name" value="RNA_POL_N_8KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC69688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="69" mass="8000" checksum="2F1DB9EF95A63BA2" modified="2024-07-24" version="1">MIIPVRCFSCGKVIGNLWDSYLELLAAGVDEGDALDRLQLKRYCCRRMVLTHVDLIEKLLMYNPLSRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L567</accession>
    <name>A0AAJ8L567_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_104761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012803.2">
        <property type="nucleotide sequence ID" value="XM_019154063.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L567"/>
    <dbReference type="GeneID" id="30170668"/>
    <dbReference type="KEGG" id="kpin:30170668"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC70809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="237" mass="26254" checksum="2D3B12EA7E25EC2D" modified="2024-07-24" version="1">MMGFKKKFSSLIPADARNHLQNALTVEWEGQGKTVLVDLPETNKHQNNEVEMAGLTSNSAAYGRLIDDDDDIPYSRPSRSDYHNYSKSYQSTTHKHRKSPSYSSKNLPPIPPNQSESVYTYNQNPFETEYESPQTSSSSSMFSNNSPYTTYSPSLGNQASFGINEGYNNGSLNRKMINGGGERKMPNPWSKHREDDIDFLGDLGGVRNGGLGSPTSSNGTRDSQGSGNYNSLDNPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L582</accession>
    <name>A0AAJ8L582_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutaredoxin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_104252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059026.1">
        <property type="nucleotide sequence ID" value="XM_070202925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L582"/>
    <dbReference type="GeneID" id="96955744"/>
    <dbReference type="KEGG" id="kpin:96955744"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WWC70302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="70" mass="8328" checksum="ACEDB177A6E92D97" modified="2024-07-24" version="1">MAPRIRLPRFTLFTGGKECSLCEVAKQDLANLRRSIPFELDLWNIRDPPIGANEREAKKWRRLYQYDICF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L6H2</accession>
    <name>A0AAJ8L6H2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_104161</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059012.1">
        <property type="nucleotide sequence ID" value="XM_070202911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L6H2"/>
    <dbReference type="GeneID" id="30172633"/>
    <dbReference type="KEGG" id="kpin:30172633"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05676">
        <property type="entry name" value="M20_dipept_like_CNDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017153">
        <property type="entry name" value="CNDP/DUG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF4">
        <property type="entry name" value="CARNOSINE DIPEPTIDASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037242">
        <property type="entry name" value="CNDP_dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="10">
        <location>
            <begin position="210"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="9">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC70211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="474" mass="51865" checksum="49114BE12FCCBD12" modified="2024-07-24" version="1">MAADPQFLKYVDEHQDDYIKRLSDAVAIASVSGNLAYVKDVEAMGEYLVQQLTALGATVEKRPIGTHTLEGKEVDLPPVIIGQVGNDPKKKTLLVYGHYDVQPALKEDGWLYPPFELTPDPKGSGKLYGRGSTDDKGPVLGWINVLEAHKNLGIELPVNLKMCFEGMEENGSVNLDKFIESEKDKFFSGVDCMCISDNYWLDTKTPCLTYGLRGINYYEIKINGPDRDLHSGVFGGTVHEPMTDLITLMSKLVTGDGQILIPGVKEMIAPLTDDERAKFEAIHFAMKDIHDAVGGDVTIYNDGVKTLMGRMRNPSLSLHGIEGAFSAPGSKTVIPCQVKGKFSIRLVPNLTVAGVTEKVVEYVKAEFAKLGSKNKLDVYLTHGGEPWLHYSYRAAHKATEAVYGQTPDYTREGGSIPVTLDFANILGLNVLLLPVGRGDDGAHSTNEKIDTSNYINGTKLLGSYMYELAAIAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L7P5</accession>
    <name>A0AAJ8L7P5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I206_105670</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059264.1">
        <property type="nucleotide sequence ID" value="XM_070203163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L7P5"/>
    <dbReference type="GeneID" id="30171797"/>
    <dbReference type="KEGG" id="kpin:30171797"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140575">
        <property type="term" value="F:transmembrane monodehydroascorbate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08761">
        <property type="entry name" value="Cyt_b561_CYB561D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045150">
        <property type="entry name" value="CYB561D1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422:SF45">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422">
        <property type="entry name" value="OS05G0565100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="13">
        <location>
            <begin position="115"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WWC71712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="257" mass="28112" checksum="1DE36A77423ED7DB" modified="2024-07-24" version="1">MSSSTREEVAPLLPSTNADSEPSGLRGESSESTPGPAGNLDMVPTTRDKLALGSIGAGLVLVLGTTWYLVFSGDLKAMGWFAVHPPMQSLAITAILLGITPLQPPSTNSSIKQNRFKSHQSIMLGLALPILTIGSLAMVYNKYIHGSSHFTTWHGKLGLISIIWIITQAFIGASSVWFNGKLFGGKENAKKVYKYHRLSGYLLITLMLFTIYLAGIHSDWANGRKHLNLRILAYYVGLPLIWIGLEVRSRPSKMKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L8F3</accession>
    <name>A0AAJ8L8F3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Alpha-aminoadipate reductase</fullName>
            <ecNumber evidence="6">1.2.1.31</ecNumber>
            <ecNumber evidence="5">1.2.1.95</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">L-aminoadipate-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">I206_105184</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+) = L-2-aminoadipate + ATP + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46936"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.2.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12308"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(S)-2-amino-6-oxohexanoate + NADP(+) + H2O = L-2-aminoadipate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12304"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.31" evidence="6"/>
    <dbReference type="EC" id="1.2.1.95" evidence="5"/>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059172.1">
        <property type="nucleotide sequence ID" value="XM_070203071.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30172276"/>
    <dbReference type="KEGG" id="kpin:30172276"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004043">
        <property type="term" value="F:L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009085">
        <property type="term" value="P:lysine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014397">
        <property type="entry name" value="Lys2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03443">
        <property type="entry name" value="alpha_am_amid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF1">
        <property type="entry name" value="L-2-AMINOADIPATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001617">
        <property type="entry name" value="Alpha-AR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="18">
        <location>
            <begin position="881"/>
            <end position="958"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="WWC71231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1415" mass="155154" checksum="769357447FBE223C" modified="2024-07-24" version="1">MSVNQNGPQGNDLKQKLDRWSKRLGTLPSLALPTDYPRPTPSKLVESTQTLPIPANLAPVLGKLTYEFSTLYPSSAPPTPYHILLTSFAILLFRYTPDPSMVICTSANGTSHPLLLKLDIAVENTFFDVLRQIMEREAEASEDIVSINSLVDHLKPEGPLFRVRFFDSTQVQSDPSTSLATDLTLFLLTSPTDVPATRSAIAPLYLRLAYNSLLFTQSRITSLLESLLQLLSSAASKDPSHPIGSLPLRTTVQAEALPDPTADLDWCGFVGAIPDIFSANAKAHPDRICVVQSESAPGQTIMDGPSRGRRIFTYQQIDEASNVVAHALLKNGLERGEVVMVYAARSVEMVVCVMGILKAGGVFSVVDPAYPPSRQNVYLSVSTPRALLIISSAGVLAPLVSDYIKENLNLRLLVPAISLTENGVTGSRSGEEDILSPYQQHAKTPAGVVLGPDSPATLSFTSGSTGIPKGVKGRHYSLTHFFPWMGQRFGLNETSKYTMLSGIAHDPIQRDMFTPLFLGAQLHVPTADDIGTPGRLAEWMADSEVTVTHLTPAMGQLLSAQATREIPTLRNAFFVGDVLTKRDCTRLQALAKNVCIINMYGTTETQRAVSYFAIPSVNDDSSFLSTQKDLIPAGQGMIDVQLLVVNRTDRNVSCAVGEMGEIYVRSGGLAEGYLDPSATAEKFVTNWFGEGVQREDTLVKNKPDAAKHWFGIRDRMYRSGDLGRYLPDGRVECTGRADDQIKIRGFRIELGEIDTHLSRHPLVRENVTLVRRDKDEEKVLVSYFVPIDGDDLDGLMSSSEADGEENGTADLGTEMIKGVKRHRRLIKDIREHLKKKLPSYSVPAVYFPLKKLPLNPNGKIDKPALPFPDTTLLAPTPAANADHTPTQKTIHDIWLKLLPSPPPSVSLDENFFDMGGHSILATRLIFEIRKTFVVNAPLGLVFDKPTIAGQAAEVDQLRNSDLRGADGAADGKADTSGDVDYAADVPTLIKELPEKFDPLPSDFNEKKLTIFLTGATGYLGAFILKDLLSRRVAKVICLVRAKSSEAGLQRLRESGEGRGVWDENWIKDGKVEAVIGDLAESNFGLSTSEWTRISKEADSILHNGAIVHWVYPYPKLRAANVLSTLTALRLCTEGKSKQFSFISSTAVMDNEAFIAKSDEAIANGENGVPESDDLSAGAQGLQGGYGQTKWVCERLIMEAAKRGLNGWTIRPGYILGDSKTAVTNTDDFIWRMVKGCIQLGLIPDINNTLNVCPVDHVALLASCSVISQLPNKKYSIAQVIGQPKIRFNDLLESLIIYGYKVLKVEYIIWRKKLEQHVIETQDNALFPLLHFVLDDLPTSTKSAEMDNKNSKELALINKENPINGVDLEKIGLYLNWLIRAEFLEKPTEFENKNIKELPKLNGIAMKAIGRTTAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L931</accession>
    <name>A0AAJ8L931_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase S9 prolyl oligopeptidase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_106933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC72969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059530.1">
        <property type="nucleotide sequence ID" value="XM_070203429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L931"/>
    <dbReference type="GeneID" id="96955780"/>
    <dbReference type="KEGG" id="kpin:96955780"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="1">
        <location>
            <begin position="20"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC72969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="119" mass="13873" checksum="9D9C8AF778D660EE" modified="2024-07-24" version="1">MNVYTFKNGLKMNNIFRRYLFETEEDYTKELQKWSAMYHIDPANNYPPVIIVHGKSDTIVPVTQSHQLAEKLRKMGVEVRENYVDGMDHLFEAYLAGPEDPMWEKAVVPVLAFVKKHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LB30</accession>
    <name>A0AAJ8LB30_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA ligase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_107516</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059638.1">
        <property type="nucleotide sequence ID" value="XM_070203537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LB30"/>
    <dbReference type="GeneID" id="30174213"/>
    <dbReference type="KEGG" id="kpin:30174213"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903461">
        <property type="term" value="P:Okazaki fragment processing involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF12">
        <property type="entry name" value="ATP DEPENDENT DNA LIGASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00333">
        <property type="entry name" value="DNA_LIGASE_A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="5">
        <location>
            <begin position="432"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC73544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="933" mass="105940" checksum="C3488D5B89B70845" modified="2024-07-24" version="1">MDIPFESFAKLVFHLGNPPKSTQTPSKTSKALSPIKIFQSWLNHLAKPFPPGTGKHLFRLLYPHEGSRRRYGLKEAKLALELGRIMGVEGLSKWDCVTWDNNDRGTGCLGKEIELAIRDRSTSSKKSTMTIRELDLLLDELATSSSFSQLSQNPSTVRAPQEILLTLYRESNLSPYGLCVLTQIILRDLRPLLNPLPKLPIRNPTTMLRLKSNTGPEQLTLRDAMICWDKRMWDFYTGGTGNIDVCADMIENLDKTNLEGIVMTGPKLGTNVKIPKCRKGRSISDALSEFTDPRYGPPAEEIWAETKYDGYRLQIHVTCSNGESSIKIYSKSTRDSTEDRLNTHSIILASLSLPVPSYLPIHHTLKQRLTDLPMQHNRKGISSIILEAEVCPYNESSREGGRAPGIEEFWWLGHAGVTTEPALINHFDAAFSKHSAKHLCLIFFDVLYLNGQSLIHRRYEDRRIILEQIVQPIQGFSHLAERTRISLDVNRQSALQSLEEAFRRSCQRREEGLVLKASGSTYTNMRWQWVKLKKDYIPNLGDCIDLVLLGAGWDIDRARDLRVDTSVFTTFYLGVLTNPHRTTFRKELPNFEILFKVSYGPDRTQLDNYNECLRYGKWGNKPFDKDDPFKRRLIGLSWTYSLQKGMTPPSVLFERPLCAEVMGAGFQKLPGSNYYEIRWPRLQKIYEPSERQWVDALSAQDLIKTAHQSLGYNIPTNSTYSPPSGEDSIRAMWRSHSTINLIDIPQLVSPTSPKSPKRVKSEPNIALLRDTSPSPFISHQTASNEFVNQAGRKLNDIMTNGIETSRQPIHPTSKSPEICTRNAEEALIPEIPNIPRPITPNNTIILGPPLPITPRKSPHRIIAPHISPVKRLISSIDWTNIDIRNQSTPNQVFSKRLKLNEIAKEKVKKNQIIKPLSLRSRLKLISRRIGLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LCF8</accession>
    <name>A0AAJ8LCF8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Uracil-DNA glycosylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_106995</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC73030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059539.1">
        <property type="nucleotide sequence ID" value="XM_070203438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LCF8"/>
    <dbReference type="GeneID" id="30173831"/>
    <dbReference type="KEGG" id="kpin:30173831"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008263">
        <property type="term" value="F:pyrimidine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10028">
        <property type="entry name" value="UDG-F2_TDG_MUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015637">
        <property type="entry name" value="MUG/TDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12159">
        <property type="entry name" value="G/T AND G/U MISMATCH-SPECIFIC DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12159:SF9">
        <property type="entry name" value="G_T MISMATCH-SPECIFIC THYMINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="5">
        <location>
            <begin position="141"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC73030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="463" mass="52646" checksum="68A9EE6F7D817A84" modified="2024-07-24" version="1">MKLKVPVIELASPSKEKRAIGEDETKSPSRRISPRKRIRKVVKDEHEYDENQSEDASEYEEIQSPAIVSSGKRSRKGKEQEIDLGILKKSKNKIPRGYAPPEAYSHLRPVNDLLEHDLHILFCGIKGKANVADCRDYGVIGKRSSTMGHHFSHPTNKFWRSLHQSGLTPRLLDPTEDHKMPAYGYGLTNLVDRPTSEQSELSTLEMKLNVFNLTKKFLKYQPKLVCFVGKKIWDVYESVISKTATPIESVQEVKGQLYIESKMESSSSSSGSHSKIKMKEEKIDIKEEDIISSSNNGSLSETKVAVKKELLNSPESSSLSPISSQEQTSQLKIENTVNIDVDSKLSSLESKTIKTNAILKAKKSKVDPFNATKPRKYRLPHHELNFHTIKGYTYFWVVPNTSGLERTPLSEQIINFTSLKLFMEDLINDWNPINAHEDDWRDIDPFGVEFTIEEMKKKANQQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LCM7</accession>
    <name>A0AAJ8LCM7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">26S proteasome regulatory subunit RPN2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_106764</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the proteasome subunit S1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059494.1">
        <property type="nucleotide sequence ID" value="XM_070203393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LCM7"/>
    <dbReference type="GeneID" id="30175717"/>
    <dbReference type="KEGG" id="kpin:30175717"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000017">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016642">
        <property type="entry name" value="26S_Psome_Rpn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048570">
        <property type="entry name" value="PSMD1_RPN2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040623">
        <property type="entry name" value="RPN2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18004">
        <property type="entry name" value="RPN2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21505">
        <property type="entry name" value="RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015947">
        <property type="entry name" value="26S_Psome_Rpn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit 1/RPN2 N-terminal" evidence="9">
        <location>
            <begin position="8"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome regulatory subunit RPN2 C-terminal" evidence="8">
        <location>
            <begin position="773"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="809"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="900"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="937"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="827"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="849"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="869"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="942"/>
            <end position="956"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC72800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="987" mass="107654" checksum="C7F37942783D0968" modified="2024-07-24" version="1">MPVASVTTSALGSLTLLEDEDKDIRVYALNHLLSIVGQFWAEMSDKLSYLELLADPMSKELPIESRPQAALLISKIYFYMGYLEEAVEFALKAGSSFEKEKEGEFRETIISGCLDRAIDQTSRGEKIDPALSNIVDSVLRSTSGENGKLAMGLALSLRRLDLVEMIYLTSRASSQPSTSSQASSSRPTHDESLLRYVLSEVVSGASGNESWSGEFRSNLFNLLLRLFNFNPNPDWNSITTIWAQNFDVDACGDALVKLVKDGNHLDAYQIAFDLNEVAPQAFIDGTRSKLAERGLAPPEENPDESDPQVILDNILVGVTSAELFLNFLNKNNKTDMSILKVTKDTLEDRYSIYHSAITFTNAFAHCGTTSDKFLRENLDWLGRASNWAKFSTTAALGLIHKGSWVNGVKVVQPYLPGGSAPNKFSEGGALFALGLIYNGRKELAEVELKKGLGETMDPIIQHGAALGLGVSAIATADEDIYDQIRTVLFTDNATAGEAAGYAMGLVMLGTASEKALDEMLSYARETQHEKIIRSLAMGIAFVMYAQREKADGIIRILTEEKDAILRYGGMFTIALAYAGTGNNKAVKKLLHVAVSDVNDDVRRAAVTALGFVLFRNHTQVPRVVQLLAESYNPHVRHGATLALGISCAGTGLETAVELLEPMTKDPVDFVRQGAYLSLAMILIQQSEAQSPKSASIRELFSKVVADKHEDPMARFGASLAQGIIDAGGRNCTLNLSTRAGTLNMNTIVGLTLFVQFWYWFPLAHGLGLAFTPTALIAVDDKLKLPKIDITCNAKQSLFAYPSTEKKVEEKKKDKAKTAVLSTTAKAKARDRQKKVEAGEAMDTDEKSETAGTSDKPSTSVPAQKKKPSEPSSYTLSNLSRVTPNQLQYISFPSEGRYAPIRPSFEKPDGINASGSIVVVKDNTPEKDGEYVELDKSLWPGQSPEQDAQNEVPQARSSAEVGAVSTTGAEEEDEEIEPPQSFEYPFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LCZ8</accession>
    <name>A0AAJ8LCZ8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_107877</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_070203617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LCZ8"/>
    <dbReference type="GeneID" id="30174577"/>
    <dbReference type="KEGG" id="kpin:30174577"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056840">
        <property type="entry name" value="HEAT_IPO9_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF9">
        <property type="entry name" value="IMPORTIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25018">
        <property type="entry name" value="HEAT_IPO9_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="6">
        <location>
            <begin position="23"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="937"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="945"/>
            <end position="956"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC73905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1044" mass="116029" checksum="73CCEF5C170CF5CD" modified="2024-07-24" version="1">METQVLSCLQATLNPDEAIRKNAEEQLKQLFLMPEGGLSLAKILLAQEADLAQRQIRVLLQQYINQHWTPASASFQHPITPIETKSQIRPIIFSGLSDPQRKIRLSAAFALSTVARFDWPDDYPDLLSQLVGLLGRSSNSVHGAMRVISDFVRNDLSEDQLLPVVQDLLPAVLGILGDPERHSATTRAQTISVFRQTLRMLETVKDEHPASVKSAMDSLSPVWLSAFTQLLSLDASEEVRKNWEELSLRIEIFRTFSLFHNAFPKYLHPHLPTYIPLAIQNLHSLQLQFQAFYLTNGDDAPEPPSPVSDVGMLDPRIDITDLACAIFDFLTPAVRTKNAPAVLLDASGSGNETMQGVVDIVLQYTQITRENEEEWMEDPNAFVIDEDDETEQYGIRSSGYDLIGSMMDKWSKPVTLILQSKVQEKIQHSAQLKASGNADWWKPLESALSLVGGVSDDLREILEEDEAGGKTPTFDVRYLFDQVIPGLLQQAETPFLQGRAFVFASQFASSLSKPLAGQYLAAAVQVLNSQEISVPVKISAVKTIKNFCRHIPSEVIQPQSRQILSLLLPLLPEISNETLYLVLETIRAVFALDTNLINGESVGEIAVRIYDVWVKYTDDPVTTAIVEETFESLASLPDPTVAPALVRLIGPKLAEAISTPVDDDTVHIPGEAVQLANSLIRTRGGPLEPELIGSVTVAVMGVLRTTDDMDVIQHGMIHLTLVVRKDCDKLIQWHDREGNNGIHSIFHLLSRFLAPTFSESGGIFVGELIMHLFRKAGSVMAPVLPDLLRAIVDRLTTAKLPSFIQTLALPFAYLFGTEYTTSTIDLLTSFSVVTNGAEKSGLQVVLEAWCEHSDTITGSWNIRVSALGLSKLFMADDSRLKGVVCKGDLIVDERNRDTIMTRSRTRNNPNQFTQIPFPLKAFKLILKDVQSEPLQKDKGKKVDYDIEDDDGDEDWDDDDLLAGGDEVGEFDYLSSWLDTKDGNENDAQDDDEDLKSDPLAQIDMGQHLTDILRQSYGNNNNDIHFMINELSDVEKNTLRGVLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MLD1</accession>
    <name>A0AAJ8MLD1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prefoldin subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_101638</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058533.1">
        <property type="nucleotide sequence ID" value="XM_070202432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MLD1"/>
    <dbReference type="GeneID" id="30174761"/>
    <dbReference type="KEGG" id="kpin:30174761"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23156">
        <property type="entry name" value="Prefoldin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016655">
        <property type="entry name" value="PFD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016396">
        <property type="entry name" value="Prefoldin_subunit_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="93"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="213"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC67726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="27394" checksum="D5E56A3CB08336BD" modified="2024-07-24" version="1">MASAGPSKGQMETNPRGIPKAPFVADVDEYVGGKDAEIQSTMKKFEETTAKYRYMEISLQQRRKALLTKIPDIEQTLQVVNFLQIRRKKSLGEKVEEEKLSDDEDDLDDLEEEDEGKKKENEPLKTLFELNDTLYAEAQIEETGQVGLWLGANIMLMYPLQEAIDLLSNKLQTAKKSHEETVEDLEFLREQITIMEVNFARVHNWDVKRRREKGITGQQSGLLPSQRGEGKDDSDDERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MLM1</accession>
    <name>A0AAJ8MLM1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RTA1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_100115</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058237.1">
        <property type="nucleotide sequence ID" value="XM_070202136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MLM1"/>
    <dbReference type="GeneID" id="30169581"/>
    <dbReference type="KEGG" id="kpin:30169581"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF1">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="296"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC66214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="35170" checksum="136761E82EA9CBC2" modified="2024-07-24" version="1">MPYNGPINNPPAIGEAPFLEYGYVPSLAMGIIGCMTFLLVCGLQLWWFVKKRGTRSVHGLLFFACIIEALGYGARLYTHEHQFSGMSFLLGIFLIQIATILISASIYKSIQRGLKYMPNGDKLSPMRVRSMLTVFIILDVVWVLMQIAGQYFWASAQAAEIVNATPMFAIGTSTVIFLSGNVLQAITIIIITVFCYVILKRSTKVLAMTSPETIVPHIKPLMAQIMISLGLFFIRLLIRIAEGAQGAYENAATHEIYFGIFEYLPIFAIVLLWAIRPLHKFIFPLGHPKYHTQETAQDATTSSVSGSGLNAVEHGAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MLU2</accession>
    <name>A0AAJ8MLU2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RAVE complex protein Rav1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_100813</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058381.1">
        <property type="nucleotide sequence ID" value="XM_070202280.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30168883"/>
    <dbReference type="KEGG" id="kpin:30168883"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052208">
        <property type="entry name" value="DmX-like/RAVE_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022033">
        <property type="entry name" value="Rav1p_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950:SF9">
        <property type="entry name" value="RABCONNECTIN-3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950">
        <property type="entry name" value="RABCONNECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12234">
        <property type="entry name" value="Rav1p_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAVE complex protein Rav1 C-terminal" evidence="2">
        <location>
            <begin position="688"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1457"/>
            <end position="1503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1457"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1489"/>
            <end position="1503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC66906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1538" mass="172193" checksum="71E408E75EA17318" modified="2024-07-24" version="1">MPLRLRQAVAGRPNALSTRNVGGIVLNEKGYIIYPSGSNVVLTTPEGDLSDTLPFWASLHHRATTSTPGNVRGVCCSQVENIIVAWSESHVVLWQHSSTKKAGSWNNHSTVLASSAITSLDYISGTLVLGTQNGIEYWRMDPQAEVVVWDRLWARPYPTPSDIHISPASGHIAWYTKGQKSAYVLGTDRKNQAVGMAQEIRHPREISWIGWRKPSIGSVDSHLYTITTNSVFRIYSPVLDDPSWFQLLSSLDHKAFSKSAKLDTGKGKEPQSNQFGAMWVWDAEILREAVKGDLTRIREKQIEVPVNAVKLLQGLESEENDIIAWISENGEIVLRSIVNMERKPPTLLKTLPLSVSTLPILSASSSLSSAQLLYIPGPSAALHALLPPTEERPTATSHRISLIKLLSSKQAAIITESASTTLTETGRVQLSNPIEKFARTPNGRGLLAICENGEIGTWYKQQLSLKPAKWHLGPRTLIGRGHWTAPTVPSEAALFAKGRAIVLCTRSSDGHPIITLQHLDSNASEPREPLMLPHFNPKKDDHVEMLLAVSDIDDGYSGGNRRTQRAIITAATRNGEAWVWRVISRITPKEGDLETQPEIQLVSHYRLPLDDLHEEVIPKMILPVDPMGWHQSVIDWTTDTPLQDLILTISSDGDLEFWTPRIGGHLAGQQLDEKVKYGDIACENREVEKGDEAWIKTGTVKTGRQNILMARCSSRKKTVLVCELEDGRHEMTIWDSKVSEFSTGLELTHIFEQGDIILDLDWTTTSDLQSVLAVGFAHKVVLVCEQRMSYIETTPGWAPFLTIDMERYTPVPISDSIWLAGGALAVGTGNQIYLFSRFLGGDTPSPSPAGSVKSVALDEEEPEDIFQLIAHRNGPLVDYHPIQLGQCLLWDKADLVKGILLDLLKSYKKCEEDGKERIRFSRLDPSEFYSKRKRAKAVKVNSNKYDGLFDSFQPPQDDEDDEFTDRAVSELVDRLNGNIAFPLSTPEKSFLATIAQATLEAEQQRRSLDLCGMRYLYSLRMFANWDRLSSISNTPISASTSTFPNHNMLGADHKEEKRNNHFSFRNIVWATHSESHELLLSASKQMCKDGKLLWKDARRMGIFLWLKPGETFKSQLEDIARNRFMQDEDRDPTSCSLIFFALGKKKVVHGLWRQAPSHKEQTLMLKFLANDFELDRWKTAALKNAYALLSKQRYEYAAAFFMLGGAPKDAINVCLRHLNDWQLAVALARIVENQEQDGKSIGPLLRWILQDTVLPIAFKGGHRWLASWAFWTLGRRDLSVKILISPMNDIALDFASDPDHPLEVGNPDNDDPSLLLMFQHLKSKSLQTAKGTNEVSTKLEYDFVLHNARVFFRMGCHNLALDLLRSWSFERPFFPSRTKQITRTQSIAPATPSSIPSPSVSLSTISTSPISARPTISGLNNLTSSYIGHNRRPSFMLTSEKRRESLFMDIDVLAESSNVTSETQTPIESNAHTPDGASTPEEVITNGHTIHEETNESDRADKEIEEIKSPPKKIGNLMKELKQDVQQGGMEFNMDNFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MM72</accession>
    <name>A0AAJ8MM72_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA repair and recombination protein RAD54B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_100360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058282.1">
        <property type="nucleotide sequence ID" value="XM_070202181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MM72"/>
    <dbReference type="GeneID" id="30169334"/>
    <dbReference type="KEGG" id="kpin:30169334"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18004">
        <property type="entry name" value="DEXHc_RAD54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000020">
        <property type="entry name" value="DNA repair and recombination protein RAD54B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="355"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="686"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="978"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="993"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1026"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1053"/>
            <end position="1063"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC66458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1115" mass="124004" checksum="969A568AB73009EE" modified="2024-07-24" version="1">MTYSPSAGPSKKRGLAAIIDSVPTQADHIPDSCSEGSNSDLEDNDDDDVDMSVLPTPRPIPLTPHSVSSRPSSKGKERAIDAPRVETTVGMSGRNVYHVVKPGQYAQYFAVQWRKPQQKKTWDGDAFIKLEGQKMTMIDEEGACKGTTGTGGRELGEDQEWKIGGFDVLIEREVDIQEFKAGTGILNKPKATGKLGPTAYRPATFAKPFKAPTQTHAPKPVAGYIPGRTSSEGLTSAPEGVPLSYKPDPVTPLSKPIPAKSFYAPSATKSSAKGSKIVLGEKSSKERLQWGGALHNPHAEGAIVMPRPPEHLMKMWRKKDPELDVVDVVVDPILGSLLREHQKEGVKFLYRCVLGYTAAEAEGCILADDMGLGKTLQTITLIHTLLFQSPFYNKSSTIQKVLIVCPVTLVENWRKEFRKWTSNKTDKRINVLVADGTDWRVSNFVNNKSQQVLIIGYERLRKEIKDLVSCIPPIGLVVCDEGQRLKTKDNKTTQALNLLKTERRIILSGTPIQNDLAEYWAMVDFTCPGLLGQYRAFNKQYERPIVAGRAVGASAKVVEAGEEKAAELNKLSREFVLRRTADVMENFLPPKHEYVLFVAPSILQLSVFAKILNPSITSGFLGGRGQQSLGLIDMLRKISNSPMLLRKRDEDNSSLNELGSAYSEAKSAIPLDTNVNDVTTSGKMLLLDKMLHSIYEETREKVVVVSNWTSTLNLIQDMLKIRKYPFLRLDGSTPQKQRQDLVDTFNRDVRREESFVFLLSSKAGGVGLNLIGGSRLFLFDSDWNPSTDLQAMARIHRDGQKKPVYIYRLLTTNAIDEKVYQRQITKMGLSDQMMEQGETSKESKDSFSHAELRDIFTLNLKTDGCQTHDLLGCDCNESHKLADIGSEENSTVLGDEGDDDDEERRKGFVNAAQYDPKPTAKMIQKAAAEQQQKLKALKKWSHFDSYDHYSFRNVGDTLLYNMLYSAWDSDEDAKGAAVAQTDEVVHGKSASKTGKDRGDDVVRKKRKVIQETEIENRDPVDKVLDSADEEDDEDKGDVDKARSDSDDSTVEIPSKRKSVEKAKSRSGSKRNSSEEYEDCLGMSRKKKHDLKRIADSGGAGRVMYVFEKISKAKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MME8</accession>
    <name>A0AAJ8MME8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_100901</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058392.1">
        <property type="nucleotide sequence ID" value="XM_070202291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MME8"/>
    <dbReference type="GeneID" id="30168794"/>
    <dbReference type="KEGG" id="kpin:30168794"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042595162" description="Ricin B lectin domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="3">
        <location>
            <begin position="90"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="417"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC66994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="459" mass="45425" checksum="8F67D04FE810ACD8" modified="2024-07-24" version="1">MFNLVTLLPLLALIKSGQAKPLPQAGDVGTATSTNSSAHAGYPPATSSASTTVNTNPASGQPSETSNNLVAVDQSTPTDSIYSNATLHGVQIQSYRDGKCLSPDPRTTLQDGLPVDLYPCVNSDNTSVALAWDITPGVGSLIISGTDFALVADEDDIENPNALVLKQSCGCEDLTPWYTTNDGRISIYGAGVCLTEDKDTDKSGPDQDLGIVLYKCTDQDTDQMFLTINNSTHDLEPIVPPNAEYSAARESAIAAAQTGTMTAPGEAGTTSSKDAGQIAADTATTSTQNAESTSNPNGDGTATDSTDTNGKNDAGEAGGDGTGSVGGSATATSSSTSQNPEATSNPGGNGGSIDSTAQNGGNGGSTDSTAQNGGNGGSTDSTAQNGGDGGSTDSTAQNGGDGGSTDSNTQNGGDGGSTDSNTQNGGNGGSTDSTSQNSGDSGSTDSKAEDGGSEDGASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MNC2</accession>
    <name>A0AAJ8MNC2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Defect at low temperature protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">DLT1</name>
        <name evidence="8" type="ORF">I206_103769</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Required for growth under high-pressure and low-temperature conditions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DLT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC69826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MNC2"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038869">
        <property type="entry name" value="DLT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40021">
        <property type="entry name" value="DEFECT AT LOW TEMPERATURE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40021:SF1">
        <property type="entry name" value="DEFECT AT LOW TEMPERATURE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC69826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="279" mass="31760" checksum="C92472419A1732B1" modified="2024-07-24" version="1">MNSHPPPLQSSYLPIYPPRFRQNDKIQQSQQQQQKIRQTKRRKKRFLPTLKGFRSFLYHSSFYLFILIITVLLVASAWGIGEQAIRNSGQRNWNVFVLVAAYVALGTISVLHVWSRVLSVKRILRTMPKPYIPTKQIDLPKSVAKHVATEYSRTAVIAHISQATTGQQEGWGRPGTKWEDKHFRTYILSTIPIMKQTLCPIAPSTASPLSLQPLLDAASSINDNGAIRLFVNSYAKIIARARYGRKEPTQADAEAVEKVVEVVLLTLEVKRRRERDMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MNZ7</accession>
    <name>A0AAJ8MNZ7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Translation initiation factor SUI1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_103092</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SUI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058779.1">
        <property type="nucleotide sequence ID" value="XM_070202678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MNZ7"/>
    <dbReference type="GeneID" id="30170273"/>
    <dbReference type="KEGG" id="kpin:30170273"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11566">
        <property type="entry name" value="eIF1_SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005874">
        <property type="entry name" value="SUI1_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10388">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SUI1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="eIF1-like"/>
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        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="4">
        <location>
            <begin position="54"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC69156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="154" mass="16454" checksum="179F99C1B0420413" modified="2024-07-24" version="1">MSTTATSKVDATTKKSKAPASSGVENLGPAFDPFAPVDDTPSVEKTVGSKNDKIHIRLQQRNGRKTLTTVQGVPKKFDHSKILKAMKKEFACNGTVVKPEQVEGGEDDSPAPVGVKPNMGDVLQLQGDQRVAVKQFLIDAGIVSQKEAKDLIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MQQ8</accession>
    <name>A0AAJ8MQQ8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_104924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_070203021.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="96955749"/>
    <dbReference type="KEGG" id="kpin:96955749"/>
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        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC70971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="31505" checksum="5D3CDF17A13F7D6E" modified="2024-07-24" version="1">MDRAFRIGQKRTVDVYRLIGQGTVEELMYERQIHKQQRSRQLNDGTFESRIHQGFDGAKTAEDQGELFGIQNIFRFDAKGFVSQNIERVRQAEDRFVQDLIEAEYDESDGEDEESEDEAGKYMRNERKARDLHRAHLNAMSKRQGENDGLSRRNNEGVVKDILGDGSGLKKEVNEDILQRLGVNTRIHEQAFRDSPEERAIYEIGVQILRSNPDMAKKIKANDLGKLGRSVAKRKQVTDVNEEPWAKRLQEKSERAKSEGSRERKRVLAELSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MQS4</accession>
    <name>A0AAJ8MQS4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_104969</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC71016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059140.1">
        <property type="nucleotide sequence ID" value="XM_070203039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MQS4"/>
    <dbReference type="GeneID" id="30170877"/>
    <dbReference type="KEGG" id="kpin:30170877"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004128">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000001">
        <property type="entry name" value="Cytochrome b5 reductase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051872">
        <property type="entry name" value="Cytochrome_b5/Flavoprotein_Rdt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237:SF1">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="159"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="88"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC71016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="237" mass="25560" checksum="83E0DE44100F4AB3" modified="2024-07-24" version="1">MSWLVPSLPTWGRSTPASSSTSLIPDEEDIDAPPPFPLLNSHQRSSAPTPSSTPSFSIAPPSPPKANGNDEEEPSDLNIAIVDAPLGDMLPPVSTTRKPNFGIQKGGLDPASNGLNGAEKKPDPVKKKKGKVALTPGHSALDWARLTSSGQDLRGVHGFQRVTLAELKEHNTPDDAWSVFNGMVYNITPYLPYHPGGEDEMMRVAGRDGTKLFMLTHSWVNLDFMLKECMVGVLVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MRA1</accession>
    <name>A0AAJ8MRA1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_104714</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059090.1">
        <property type="nucleotide sequence ID" value="XM_070202989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MRA1"/>
    <dbReference type="GeneID" id="30170621"/>
    <dbReference type="KEGG" id="kpin:30170621"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03272">
        <property type="entry name" value="ABC_SMC3_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000370">
        <property type="entry name" value="Structural maintenance of chromosomes 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000424">
        <property type="entry name" value="Structural maintenance of chromosomes 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041741">
        <property type="entry name" value="SMC3_ABC_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58104">
        <property type="entry name" value="Methyl-accepting chemotaxis protein (MCP) signaling domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="11">
        <location>
            <begin position="523"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="245"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="717"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="282"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="407"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="987"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="245"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="733"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="757"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC70763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1209" mass="138418" checksum="9425061FBBF4E930" modified="2024-07-24" version="1">MYIKTITIQGFKSYRDQVAVDPFSPGHNVVVGRNGSGKSNFFSAIRFVLSDQYTKMNREERQRLLHEGTSKTTTLSAYVEIIFDNSDARFPTGRNELVLRRTIGLKKDEYSLDRKSASRSEVDQLLEAAGFSKSNPYYIVPQGRITHLTTMNDKERLRLLKDVAGTEVYEQKRAESTRLMEETDAKRDKIAEILGTIEERLNELDEEKQDLKEYQEKDRERRCLEYALHSRDLEDVTAALDEVETERRNDIHNSNTKRKEFNEREEEVQKHEESLTTAKHALSTTQLALRQYEAEMADLVRARTEIECVIADFTTAGEAGEQRRAEVAEELRTLEERIEEASERLDGLITDANSKIADERQARETLESTQSKLAVLFAKQGRAQQFPTKAARDQYLRGEINSLTEYETDQQRRVDSLREVVENAKEQLSEAVARSAQRGREEDERRGNLRRMAEEVSALKGNLDGMQERRKELWREDGKLGQTVSNARSELDSAERAILGMMDKDTSNGLRAVRSIAKRLKLDGVYGPLYELFEVSDRYKTAVEVTAGNSLFHVVVDNDDTVTRLLDVMNREKSGRVTFMPLNRLKSQSFNYPKANDALPMIQKLQFDRQYVMAFEQVFGRTIICEDLQTAAQYTRSHNLNAVTIEGDRVDRKGALTGGYHDVRRSRLDAIKASKKWRTTYENDSTRHAEVKEGLTKLEQDISRTMGQIQVIEAKRKQSLDARGVSSTQSRDVTVRDEEGAKSRVSKLEQNLEDAEGELRDAKSKRASYEEELRSPMRQRLTDAEVTQLQGLTQDAEVQKKELLEATQARTKVIGERNGLEIELTESLRRRREELRSRLDQMEGDAGSGVLQSGEVELRNTELRNLIRSIEDLSAQVTESENRIEELTTEIAQITEDLDKVQSEQLENTRAIMKVQKNAERYLTKRQTLINRREECNNKIRDLGVLPEEAFSKYTDQRSDKIVKRLHKVQESLKKYAHVNKKAFEQYNSFTKQRDDLLARREELDESAEKIQELIVTLDQRKDEAIERTFKQVSKYFEEVFEKLVPAGQGQLVMQKRIAGYVDEESEESGMTGREKSEIDNYTGVSIRVSFNSKADEGQRIQQLSGGQKSLVALALVFSIQKCDPAPFYLFDEIDANLDAQYRTAVASMIHDLSSNAQFITTTFKPEMLVQADKFYGVVFDSQKVSSITVIDREAASDFVETAAQVGQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MS71</accession>
    <name>A0AAJ8MS71_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UV excision repair protein RAD23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_106463</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RAD23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059423.1">
        <property type="nucleotide sequence ID" value="XM_070203322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MS71"/>
    <dbReference type="GeneID" id="30175637"/>
    <dbReference type="KEGG" id="kpin:30175637"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14280">
        <property type="entry name" value="UBA1_Rad23_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14281">
        <property type="entry name" value="UBA2_Rad23_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01805">
        <property type="entry name" value="Ubl_Rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000254">
        <property type="entry name" value="UV excision repair protein Rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000002">
        <property type="entry name" value="UV excision repair protein RAD23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000003">
        <property type="entry name" value="UV excision repair protein RAD23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.540">
        <property type="entry name" value="XPC-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004806">
        <property type="entry name" value="Rad23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015360">
        <property type="entry name" value="XPC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036353">
        <property type="entry name" value="XPC-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00601">
        <property type="entry name" value="rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621:SF0">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09280">
        <property type="entry name" value="XPC-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01839">
        <property type="entry name" value="RAD23PROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101238">
        <property type="entry name" value="XPC-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="7">
        <location>
            <begin position="143"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="7">
        <location>
            <begin position="355"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="78"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="190"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="79"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="193"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC72501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="400" mass="40514" checksum="ED43586CB08E5414" modified="2024-07-24" version="1">MVKITFKTVQNKLFTVDAEGSETVGDLKKKIQETQTFPAENQKLIYSGKILNDAATVESLKIKEKDFLVVMVSKPKAPPASAASTSTPAPAAPASSAPSTETPAAPAEPASAPTTEAPAAAPASTESSTAVESGLGGSFVTGAALQAATDGMVEMGFERDLVVRALRASFNNPDRAVEYLMSGNIPQVEGTGPAAQAPAPSAPAPAAAPSEPAQAAQPVSAPAAAQPPAPQQTGSAGSAENLFAAAEAAMNRDRGVPAGAGAGAGGLGGAPGGAGGPGAGGLANAPHLQQIREMVQQNPALIQPLLQQIAASNPQLAQLINENPQALYELLGAGGEGDEEDEGFGGPQVMQVNLTQEEAAAVERLEALGFDRQMVLQAYMLCDKNEELAANFLFDQGEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MTR6</accession>
    <name>A0AAJ8MTR6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="9">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_107340</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase H family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="9"/>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059602.1">
        <property type="nucleotide sequence ID" value="XM_070203501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MTR6"/>
    <dbReference type="GeneID" id="30174035"/>
    <dbReference type="KEGG" id="kpin:30174035"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18037">
        <property type="entry name" value="DEXSc_Pif1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.970.10:FF:000002">
        <property type="entry name" value="Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.970.10">
        <property type="entry name" value="Ribonuclease H1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037056">
        <property type="entry name" value="RNase_H1_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF5">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="132"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="56"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC73373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="622" mass="68985" checksum="77722CFC7697CE1B" modified="2024-07-24" version="1">MPKAKWYAVRVGRRPGVYATWEEAARQVNGYPGAVHKSFPHPKAAEGWYRAGLRQRPANTSSSVRYNDPEQSIKTEDLNGGIPSTNHVKRPYTHPTSMVTGPAVNTDIGPSSSASEPDLSSQQEEILKRILKGENYFFTGSAGTGKSVLLRAIIKAFRQREEDERILEEDRWRRYLSGEVNNERSEVQRWKLGVTASTGMAGVNIGGSTVHSWAGIGLGELPAEKLYQNVLRNKITAKRWKTTGALIIDEVSMIGAKLFDKLEYIGRKIRKSTEPFGGLQIILSGDFYQLPPVTKGSSSTTSFAFEAESWERVIPKDNMSALTRVFRQKEDAFVRILESMRRGVIASKDIDVLKGLERTVEYPKGVEPVGLYPQKAEVAAINADRLKALDSPSQVFMAFDVPGITSQGYALDTARATHSLNRNTIWPQELELKIGALVMLVILTPNQDGVLVNGSTGTVVDFMTIAEALAVNIRPVSGSFGLSPDTKVRWPVVEFIPSKFASGNIAKRVLVPQMTVDVLNASGRPEATRHQIPLILAWALTIHKSQGQTLERVKIDLNNIFVEGQTYVAISRAVSLDTLQILNFSAHKVMAHSRVIEWARPFEQEQKDEEEWDELMATADLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MU04</accession>
    <name>A0AAJ8MU04_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">M protein repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_107866</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
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        <location>
            <begin position="1046"/>
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        </location>
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            <begin position="473"/>
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            <begin position="860"/>
            <end position="998"/>
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            <begin position="1"/>
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        </location>
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            <begin position="55"/>
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            <dbReference type="EMBL" id="WWC73894.1"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MU37</accession>
    <name>A0AAJ8MU37_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NADH dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_107432</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019157474.2"/>
    </dbReference>
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    <dbReference type="KEGG" id="kpin:30174128"/>
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    </dbReference>
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        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="NDUFB10"/>
    </dbReference>
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        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE PDSW SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
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    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC73462.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="80" mass="9532" checksum="2BE45D86EC3FC8EC" modified="2024-07-24" version="1">MATTPTMDEYRQILKSRDEHIRESWIKAMEARLIREELQKCYRGEGVNHLQNCKELAEKYAGMIRENKVKGYKQIDTEMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HSD4</accession>
    <name>A0A1B9HSD4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_07844</name>
        <name evidence="3" type="ORF">I206_100029</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700119">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="WWC66129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="kpin:30176213"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF46174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC66129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="528" mass="60194" checksum="047A598A9E37FE4E" modified="2016-11-02" version="1">MPEYLENFGEPLYFSSIFEEEQDISQIDNQYVSPSPEPLNSSDQIFKSYPLSQALFQTIYNKGYTAGSTSSVSQQLTHWFKIHSDSIILITMLALTTGKMALSKRPSKSIKLLKSNTTKQIRSIGNTIPNLIKLSENSKSYTTKSSSSTNEIIEYDKIFEKLKKDLLISSSQNKFQPEPEHESEPEENIKTLSDKALIGFKEKGQTKFSGNTAKDIFYAMKKMKEMNLAGLNSHKIVIEYNSDGTKETKLEPKESEEDLNDSSIPSTYYKDPEVEIDAEDMAGEEELLSEIEEKGLSSIMALKKIWSKIEFQVVEWDETKGELIMNIFDPEKPDNLIHEGLKVHATFHDGIPTSIFHNGLIFEIEETQKDLIDGASIWKFSRLVEDVASKVTEVEREEEVNEPNLFDDIILSDRAKNAHIFEKSVPNTDVMSLIEAIGNEQKVEFWFDEKIGNSIAIGRTGKKENWKMRLAIYDLYEEPQWSEFTASVYFNGYPKTITLEELPEHPIPIVVCDEGQYVVRGREEDNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HSP2</accession>
    <name>A0A1B9HSP2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_07760</name>
        <name evidence="10" type="ORF">I206_103808</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasmic vesicle membrane</location>
            <topology evidence="1 6">Peripheral membrane protein</topology>
            <orientation evidence="1 6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="6">Cytoplasmic face of coated pits and vesicles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the clathrin light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700118">
        <property type="protein sequence ID" value="OCF46280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC69865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007499.1">
        <property type="nucleotide sequence ID" value="XM_019159447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HSP2"/>
    <dbReference type="STRING" id="1296096.A0A1B9HSP2"/>
    <dbReference type="GeneID" id="30176129"/>
    <dbReference type="KEGG" id="kpin:30176129"/>
    <dbReference type="OrthoDB" id="5512at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000996">
        <property type="entry name" value="Clathrin_L-chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639:SF7">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01086">
        <property type="entry name" value="Clathrin_lg_ch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="26"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="125"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="188"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="160"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCF46280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC69865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="284" mass="30890" checksum="AABDD4218AE925EE" modified="2016-11-02" version="1">MSDDPMADFLAREKAALGDDADLFASGSAPLAPSGMDSFADFTSPAPPSEPTKPSSPKGIEGFPSLDSPGLGGGEIRVTGVSGTGEDEDRAQFENQFPDLSGEVGYEAAPKPVFNALSPQPYGQSPYPVTAAPKPRSAQSILPPPTFNNILQSTEQEDTEPIKAWREKQAEQIKKRDEEDKQRRDEMANKAEKAIDSFYEDYNKMKERNIRENKENEAAFLEKLNEGIAKGTAWERITDLIQLENSQSKTIRPSVPGGSDLARMKEILLALKREGDKAPGAAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HST4</accession>
    <name>A0A1B9HST4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alanine--glyoxylate transaminase</fullName>
            <ecNumber evidence="3">2.6.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_07814</name>
        <name evidence="13" type="ORF">I206_103861</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.44" evidence="3"/>
    <dbReference type="EMBL" id="KV700118">
        <property type="protein sequence ID" value="OCF46332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC69917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007551.1">
        <property type="nucleotide sequence ID" value="XM_019159499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HST4"/>
    <dbReference type="STRING" id="1296096.A0A1B9HST4"/>
    <dbReference type="GeneID" id="30176183"/>
    <dbReference type="KEGG" id="kpin:30176183"/>
    <dbReference type="OrthoDB" id="7403325at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008453">
        <property type="term" value="F:alanine-glyoxylate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004760">
        <property type="term" value="F:L-serine-pyruvate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019265">
        <property type="term" value="P:glycine biosynthetic process, by transamination of glyoxylate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000049">
        <property type="entry name" value="Alanine-glyoxylate aminotransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000027">
        <property type="entry name" value="Serine--pyruvate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
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        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152:SF24">
        <property type="entry name" value="ALANINE--GLYOXYLATE AMINOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152">
        <property type="entry name" value="AMINOTRANSFERASE CLASS V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="11">
        <location>
            <begin position="66"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013049"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR000524-1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR000524-50"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004075"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCF46332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC69917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="382" mass="41116" checksum="5A5A3F2AFB88F13A" modified="2016-11-02" version="1">MSEFKQADHKLLVIPGPIEFSDPVLLANATPGTAHTSPAFIPIFGESIKLLRKVLLSKEESQSQPILIAGSGTLGWDAVGANLVERGDEVVVLNTGYFGDSFAECLEIYGAKVNQVKAEVGNVPTDESIIEALATKPKIITITHVDTSTGVLSPAAHIASLVKKHSPETLIVLDAVCSVASEDIKFDEWGLDVVISATQKGLGVPPGLSVVLASKRAVEASENRKTPQQGYYISWKKWIPIMKNYEAGKPSYFATPPVQLIYALHTALKSITAKPISERIEAHKAASKYVKDELTALGLDFVPKSRDIAANGMTAVRFPQGLKAPDVLPKLAERDIVVAAGLHKAIVTEYFRIGHMGVTAVDRQRGDLEKVINGIKEVLGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HT53</accession>
    <name>A0A1B9HT53_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_07679</name>
        <name evidence="3" type="ORF">I206_102309</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894017">
        <property type="protein sequence ID" value="OCF46445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC68384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019159370.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="kpin:30176048"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF46445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC68384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="278" mass="31715" checksum="89DC0016A548772B" modified="2016-11-02" version="1">MPLPYLKGFLAHFGSVESVAEESPPEGISASNKAVSDPLNPMQEDPVEESSKTNYHYDVILDPAKRAQWLQGNKRPKSYNLCFDPGEGDGKCHYNEATFCWKRSIRATVEQTETNPDSGEEELIGRYEIPAAVVFHAEVQYPFTGYNHTTAYLDSFYETGEGGWENWYRRVSKFSFSCNVDLSQRDSRIEPSEQPKPVWTFGEASLILCFNTKDAESNDTTEFDYPSLGHYYQGDSYDKDIGVRRITSDQSVDFRARITLFGRDTEESQMEGIEYKPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HTA8</accession>
    <name>A0A1B9HTA8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aconitate hydratase, mitochondrial</fullName>
            <shortName evidence="8">Aconitase</shortName>
            <ecNumber evidence="8">4.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_07359</name>
        <name evidence="13" type="ORF">I206_106753</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="8">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.-" evidence="8"/>
    <dbReference type="EMBL" id="KI894016">
        <property type="protein sequence ID" value="OCF46506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007725.1">
        <property type="nucleotide sequence ID" value="XM_019159053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HTA8"/>
    <dbReference type="STRING" id="1296096.A0A1B9HTA8"/>
    <dbReference type="GeneID" id="30175728"/>
    <dbReference type="KEGG" id="kpin:30175728"/>
    <dbReference type="OrthoDB" id="2224430at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000003">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000004">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1060.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="entry name" value="Aconitase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005558">
        <property type="entry name" value="PRK07229.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF2">
        <property type="entry name" value="HOMOCITRATE DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0408">Iron</keyword>
    <keyword evidence="5 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="10">
        <location>
            <begin position="63"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="11">
        <location>
            <begin position="588"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="511"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCF46506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC72789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="793" mass="85431" checksum="A1438A7F36BFA321" modified="2016-11-02" version="1">MVILSSTRASLFRNIISKRGLATPSTLPIKDCTSITPPYPRLLETLDKVRDVLPKGSKLTLAEKILYSHLRNPEESLGGNGKIRGERYLKLRPDRVAMQDASAQMALLQFMTCKLPSCAVPASIHCDHLIQAQTGAASDLTRSIETNKEVFDFLESAAKKYGIEFWKPGSGIIHQIVLENYAAPGLLMLGTDSHTPNAGGLGMLAIGVGGADAVDALTDTPWELKAPLVTGVKLTGQLQGWATPKDLILHLAGKLTVRGGTGRIIEYFGPGVPAQSCTGLATIANMGAEVGATTSTFPYSDNMRQYLHATGRGPVAEAADAAAKRGFLSADEGAEYDEVIEINLSELEPHLNGPFTPDLATPLSSFSSFLNTNKYPTNLSSALIGSCTNSSYEDMSRVASIAEQAKAAGLKSKVPFLVTPGSELIRATVEKDGLQSTLEAVGATVLANACGPCIGQWKRDEHKGEDNAILTSFNRNFKARNDGNLKTMNFLASPEIVTAMAFSGDLNFNPTTDSIPTPNGPFKFTPPSGDRLPPTGYSAGDLSYAPSPSPVPQPNTDIAISPSSTRLEILEPFGTNFKDGQGELPPMTCLMRVKGKCTTDHISAAGAWLKYKGHLSNISENTLMTAVNDELDSINKAIDLDGKEDTIPNTMKSYKSKNEPWMLVVDDNYGEGSAREHAALQPRFYGGSMIVARSFARIHETNLKKQGILPLWFIDKSDYSKISSHDKISTKGLEKIMKGDTSSEIITLEITKPSGETLEIRTRHTLSKDQIEWLRFGSALNYIGAMAKQSGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HTF0</accession>
    <name>A0A1B9HTF0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cyclin-dependent kinase 8</fullName>
            <ecNumber evidence="4">2.7.11.22</ecNumber>
            <ecNumber evidence="3">2.7.11.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">I206_07393</name>
        <name evidence="24" type="ORF">I206_106718</name>
    </gene>
    <organism evidence="23">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="24" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="4"/>
    <dbReference type="EC" id="2.7.11.23" evidence="3"/>
    <dbReference type="EMBL" id="KI894016">
        <property type="protein sequence ID" value="OCF46540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007759.1">
        <property type="nucleotide sequence ID" value="XM_019159087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HTF0"/>
    <dbReference type="STRING" id="1296096.A0A1B9HTF0"/>
    <dbReference type="GeneID" id="30175762"/>
    <dbReference type="KEGG" id="kpin:30175762"/>
    <dbReference type="OrthoDB" id="6284126at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07842">
        <property type="entry name" value="STKc_CDK8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000408">
        <property type="entry name" value="Serine/threonine-protein kinase SSN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF495">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 23" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="15" id="KW-0804">Transcription</keyword>
    <keyword evidence="13" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="33"/>
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<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1B9HUG0_9TREE</name>
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    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1">CBS 10737</strain>
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    <reference evidence="2" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 10737</strain>
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    </evidence>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HV27</accession>
    <name>A0A1B9HV27_9TREE</name>
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        <recommendedName>
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        <name evidence="7" type="ORF">I206_06892</name>
        <name evidence="8" type="ORF">I206_102016</name>
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        <name type="scientific">Kwoniella pini CBS 10737</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
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    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">CBS 10737</strain>
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    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
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            <location evidence="1 6">Cytoskeleton</location>
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    </comment>
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    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
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    <dbReference type="GO" id="GO:0005885">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0034314">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="InterPro" id="IPR007204">
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        <property type="entry name" value="ARPC3_sf"/>
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    <dbReference type="PANTHER" id="PTHR12391">
        <property type="entry name" value="ARP2/3 COMPLEX 21 KD SUBUNIT"/>
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        <property type="entry name" value="P21-Arc"/>
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        <property type="entry name" value="ARP2/3_P21-Arc"/>
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    </dbReference>
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        <property type="entry name" value="Arp2/3 complex 21 kDa subunit ARPC3"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCF47116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC68095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="199" mass="22184" checksum="D4F877CFC72083A0" modified="2016-11-02" version="1">MPAYHSIFNHDTSSRQVGNMALLPINTKVRGPAPLAADPSQPDIIEESLDLFRANCLFRNFEIKGPADRLMIYLILFISECLTKLSPTPGKPSPGYQEALKLLQTQAVDTFALPGDAGFPLNSLYHPPANRMDADALRSYLTQTRTELAIRLVDRLYPFEQELGSDGQPTGQSGARSNKPSKWWMSFQKRRFMGRSLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HVL7</accession>
    <name>A0A1B9HVL7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sterol-4alpha-carboxylate 3-dehydrogenase (Decarboxylating)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_07094</name>
        <name evidence="5" type="ORF">I206_101816</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-beta-HSD family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700117">
        <property type="protein sequence ID" value="OCF47315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC67898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019158788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HVL7"/>
    <dbReference type="STRING" id="1296096.A0A1B9HVL7"/>
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    <dbReference type="KEGG" id="kpin:30175463"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09813">
        <property type="entry name" value="3b-HSD-NSDHL-like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000652">
        <property type="entry name" value="Chromosome 12, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000944">
        <property type="entry name" value="Sterol-4alpha-carboxylate 3-dehydrogenase (Decarboxylating)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF51">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="7"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="3">
        <location>
            <begin position="309"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF47315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC67898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="433" mass="48068" checksum="F9AF6CBC56391C4C" modified="2016-11-02" version="1">MSSESYLVVGGCGFLGRHIVEQLLARGETQVSVFDIVQRHFDSNVTFFIGDLSKPEDVQNALYKSKASVVIHTASPAHGMGRAIYEKVNVEGTRTLLDACQQPESTVDKLVYTSSGGVIYSGIEDITDVDERVDYPATPLDAYNETKVAAEKMVLEANGVGGLLTCAIRPAGIFGPGDRQMINGFYGVIKNGQTKWQIGDNLNLGDFTYVGNVAYAHLLAADKLDSIYPYSLLRDPISSIDISLGKHKIPTSSSKPIGPNPNPTEEDLKLAEKFEKGQVDESDLRPVLRNKMDQFSNESSKDENGEEGQGISIAGQAYFITNGEPIYFWDFARTIWKQLGHIPPYTIVLPTIIGLLLATLAEMFSQFTGKEPGFTRFRVSQATQQRFYDIEKARRLLGYHPIVGLDEGMKRWTEWYSEELKKQKLAIESEKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HVR6</accession>
    <name>A0A1B9HVR6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_06260</name>
        <name evidence="4" type="ORF">I206_101769</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
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            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008583.1">
        <property type="nucleotide sequence ID" value="XM_019157970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HVR6"/>
    <dbReference type="STRING" id="1296096.A0A1B9HVR6"/>
    <dbReference type="GeneID" id="30174629"/>
    <dbReference type="KEGG" id="kpin:30174629"/>
    <dbReference type="OrthoDB" id="239865at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051150">
        <property type="entry name" value="SWT21/TCAB1_mRNA_Telomere"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13211">
        <property type="entry name" value="TELOMERASE CAJAL BODY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13211:SF0">
        <property type="entry name" value="TELOMERASE CAJAL BODY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
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</entry>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </source>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
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                <person name="Birren B."/>
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        </source>
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            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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            <dbReference type="EMBL" id="OCF47511.1"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="531" mass="57550" checksum="7079D5A3CB8A851B" modified="2016-11-02" version="1">MNINMRPTSSGSRKGKEVVEMASLSITETSSAAGRRRTEGPDEKDKEDMAMAKWRKWVVEKPIDTGSSDHSPIRSRRASPASTMATGLHGSASPRISVFTTSPRVTLSPRQFPPPAGSPLEPVGSAGSSSSSPGAGRLSGFSPKASSTRLGSGSAIDAEVCNTESVMALRDVELAIDEEVLERNERMRHYNGSQARRMSTHPRISELPNPFSDISQRLGSRRVRPIVLELIQALGHYLDAVWCITYPNRPCPWVIGVDESPMPASVRRMTMAQNGESLGSVTTWKSPMVTAVQQGKKSGHVVQPPTVQDVKFWGDEVTFAIRDVDEVVGIYKGVGWAFGSAMRDGVYGTVTSDNVLGSNGEGGGMARLLNDLEEAIWGDAQPRPTDLSYDLPIDFDPYAVPDDQELLIAASVPRGGQARSALTDFFGESRITGKQGSTAVQGGVPIMEEEIDALPDLIQNSDEQDIEDGNSETDNKSDMIKSPTLSRGRSTMTIPGVNDLPPTTEGMTLEELGKRRHLEWLNNQRLGLDSW</sequence>
</entry>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
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                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">CBS 10737</strain>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 10737</strain>
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    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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    </evidence>
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            <fullName evidence="10">PLP-dependent transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_06462</name>
        <name evidence="8" type="ORF">I206_101568</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008778.1">
        <property type="nucleotide sequence ID" value="XM_019158165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HWC8"/>
    <dbReference type="STRING" id="1296096.A0A1B9HWC8"/>
    <dbReference type="GeneID" id="30174831"/>
    <dbReference type="KEGG" id="kpin:30174831"/>
    <dbReference type="OrthoDB" id="2161780at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF165">
        <property type="entry name" value="DECARBOXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G04980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCF47559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC67658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="535" mass="58023" checksum="7333E2200953647F" modified="2016-11-02" version="1">MSPANQDDFQSSLDTVISHISKRQSSIDKIPILPTSDSIANSISSLPSSLPEIGLGVSATTNYLIENVLPGILQAQNGPRYYGFVVGGVTPAAQLADILATSYDENVQVNLHQQTASTAIDQRTLELVLDLLDIPRSTFMGRTITTGATASNVLGLACARDHLLSQSPHLPSNYSWARDGPPSAPGLPSPPIVILSLYPHFSISKAASLVGLGSSPKIIQQLSAHSEDELAFDLSKFENRLKAEQEIRRGVIVVYGVGEVNTGGFGRDLDKVADLCRQYGAWLHVDAAFGGFAGLMPELSPYTKDMDKADSLTLDGHKWLNVPYDCGLFYTRHTSSLTNIFQPPSASAPAYLASNATTVEQGIEGDLPEGTILAADVPSPLFVNIENSRRFRALPLLASLLSLGKEGYREIITKNIHFARSIAIYIDKSENYELLNSSPSHLKSSQKDSIISSNIVLFRPSKNSPYPPSIPTSSIRLTKIINDSKQLYVSATSWRGQSAIRIAVSNYLTDEKRDLQIVLNVLEKVGKGEEVDFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HWH1</accession>
    <name>A0A1B9HWH1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal RNA-processing protein 41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_06525</name>
        <name evidence="11" type="ORF">I206_101502</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the RNA exosome complex. Specifically part of the catalytically inactive RNA exosome core complex (Exo-9) which may associate with the catalytic subunits RRP6 and DIS3 in cytoplasmic- and nuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric base ring of RNase PH domain-containing subunits and a cap ring consisting of CSL4, RRP4 and RRP40.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008841.1">
        <property type="nucleotide sequence ID" value="XM_019158228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HWH1"/>
    <dbReference type="STRING" id="1296096.A0A1B9HWH1"/>
    <dbReference type="GeneID" id="30174894"/>
    <dbReference type="KEGG" id="kpin:30174894"/>
    <dbReference type="OrthoDB" id="437922at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11370">
        <property type="entry name" value="RNase_PH_RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000004">
        <property type="entry name" value="Exosome complex component Rrp41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF0">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="8">
        <location>
            <begin position="23"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="9">
        <location>
            <begin position="157"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00063066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00077929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF47622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC67592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="261" mass="28824" checksum="AE382FB173C90506" modified="2016-11-02" version="1">MSSSRIEILNDGGLRHDARRPYELRSTSFQLNTHPTAEGSSTVTQGLTTVQVSIFGPREPRQRSQASHDKAIINVEVGVVPWAQGGGGIKRVRGDKRLQEIGASIRQTFEPVIMTHLYPRSEITINVQVLSADGGILPTSINATTLALISSGISILDYITSISIGLYLKQPLLDLSFLEEQDLPNLIISCLTNSNKITLAQMETRLHIDRFEEMLNLGLEACKVLKIEMELIVKEQTEKIVERMNVKSIISSNASGMNIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HWM0</accession>
    <name>A0A1B9HWM0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Glycosyltransferase family 31 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_06580</name>
        <name evidence="12" type="ORF">I206_101448</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008894.1">
        <property type="nucleotide sequence ID" value="XM_019158281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HWM0"/>
    <dbReference type="STRING" id="1296096.A0A1B9HWM0"/>
    <dbReference type="GeneID" id="30174949"/>
    <dbReference type="KEGG" id="kpin:30174949"/>
    <dbReference type="OrthoDB" id="2139606at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051072">
        <property type="term" value="P:4,6-pyruvylated galactose residue biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF333">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 31 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="53"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="160"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="319"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="360"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="433"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="580"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="865"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1182"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="247"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="284"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="321"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="362"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="590"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1211"/>
            <end position="1221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCF47675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC67539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1221" mass="136159" checksum="746B589C02B108A0" modified="2016-11-02" version="1">MVNNYNNSNSIIEHTSKSNIFNSNSNDDKQINNHKDDKNNLIISPINEITITTIPPSPSPCPTRNRIITPQPIVQPSSIGSTNSLTSNSRSRSRSRSNPHIFGSKHSTIGDRNYFPLSSSSSSSTTTPIPTPHIHSSPNKNHKHLRPIAITRSQSHYINRHTIKDHPQEKNGNIPSIKDKSHNNPLKRLSIDDTFHNNYNNAVTTGSDVHTPTQEYGSHSGIITRRRPSISTPTSNTYTSPRSRQTSLLRSPPSVPASSSSLGWLTGNRLTLPPINNKHSTSDDEREEDEDNEEEEENSKTLRTNKKWDWRMASNGLPKYGESSTSGSASGSSSTTNTPFISMTPPSAYDVKSMPPPLPIVNSYNTSPPRTSILPSQAPLASPSNLQPLPQDPYNILPLSVPSSPLISPCVSRAPTPHQSPHPSLQDLASEYAASANVQSSSSRTESSPRTSISTSSSRYGWGTGRSDSRSSEEDDLIPPFSPITTSTSHRPVISFPRSGWWQRSLISSKGDTPVSPKINLSNNNGNPSRIIRFPVSANKFVPTGTRNWGWLFEVIPGFASSTTTTIASTDSSIIRKNDSRKNSITTKTRNRERERLMSGHSRGRSDVHGPFTSRRKSINQKVLGSKWLARVMVFVPTEPWSISLFLIFFAAFAVTLTFTIKHILNPDKEPLPWRQYCTSDYPTLYSLQDPSLPSPHVNSMVNSNPSFPSTEHIESVPVNSFAPSSSKPLTLMPLTPEHPAWPYHPHDKPPFSPEMSTKELDESLNPVGVLIGVFTTDAGVERRHMIRQSYASHWRSRRDGTEGIRIRFVMGRPRKRFEKAVQLEMEAFNDILLLDMDENMNSGKTHAFFSWAAENATVPSWEYPQPEPIASDTDTESNSVDARQGRLSPIWKGEKKPDYVVKADEDSFIMLGELEKRLRVSPRSKAFWGYLVKNTFMAGECYALSFDLVQYIHASPALRTLTRGKEDKLVAKWMNMHPEREQIVWVTERCWIYDHPKAGTVYSHGFLFPSIVNEVRTENLTGLSPSTLSLRGGAEAAKSYSSVSKFGVAYRPISTEMTVPEQVEALIEGSPLSLLKDTSLNSDSSVQQQQQQQQQTFSKIENIQTQVNKIYSNRPTRKERFLNDENELGGTVVVHYIKKNEWFQETMIALLGGASNLDDQVWHKGVSTGLGALEKRKGRVIRNGKGNDNSIEPGKFIDHNDRDEKEEEGEGVKLRKGDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HXJ5</accession>
    <name>A0A1B9HXJ5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_05865</name>
        <name evidence="6" type="ORF">I206_107537</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
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    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 3"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049984"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC73565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="193" mass="21193" checksum="4BCC5427DB88E4C4" modified="2016-11-02" version="1">MSRSAIRPIFNSFRPTFQTKIHPISRQHAPTSISSTILKRSFQNLLAPNPDSTDAPNLAINKLTARGFILSDNLVIPGGCIFHSGRAVLWDVDPPKTDVGNLELMWKDWDIGRFRVFEVVVPRPEILLFGTGQTAIPAPKAIREYISSLGIQLDVMDTRNAASTYNLLAEEGRTVAAALCPLSPIDPKTGSSR</sequence>
</entry>
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    <accession>A0A1B9HXN0</accession>
    <name>A0A1B9HXN0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL3m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_05891</name>
        <name evidence="11" type="ORF">I206_107559</name>
    </gene>
    <organism evidence="10">
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        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
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        <property type="protein sequence ID" value="OCF48024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="WWC73587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="kpin:30174260"/>
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    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
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        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="50S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019927">
        <property type="entry name" value="Ribosomal_uL3_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_uL3_CS"/>
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        <property type="entry name" value="Transl_B-barrel_sf"/>
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        <property type="entry name" value="L3_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3M"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4 8 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF48024.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC73587.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
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    </evidence>
    <sequence length="311" mass="34134" checksum="95BF3862B7D787D3" modified="2016-11-02" version="1">MRSILRSIPKSFSRGLATVAEVVEPIASSSQASSSSIIGKWTPHTLRTGLIARKRGMTALWDQDGRRWPVTVLQVDANQVVRHNPPPPTSPFHTLQIGASTRPEKTTPAQQLGHFKKAGVEPKYKLKEFQVSNDAILPIGTELNAGHFVPGQYVDVQGITIGKGFQGVMKRYGFRGLKASHGVSVKHRSGGSIGQNQDPGRVIPNKKMAGHMGTKTRTTQNLLVHRIDTILNLIYVRGSIPGSDDSFISIIDSKKLLKSKSKLNLKKGKSENEWLSNNVLSLPTPAGTSERIKNENWPAIVEWKGEGWSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1B9HYN5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_05176</name>
        <name evidence="5" type="ORF">I206_107279</name>
    </gene>
    <organism evidence="4">
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC73312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009618.1">
        <property type="nucleotide sequence ID" value="XM_019156900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HYN5"/>
    <dbReference type="STRING" id="1296096.A0A1B9HYN5"/>
    <dbReference type="GeneID" id="30173545"/>
    <dbReference type="KEGG" id="kpin:30173545"/>
    <dbReference type="OrthoDB" id="2564983at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF289">
        <property type="entry name" value="GLYCINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="3">
        <location>
            <begin position="9"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF48399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC73312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="404" mass="45115" checksum="7D364F944338202E" modified="2016-11-02" version="1">MPSTQPREIVIVGGGLIGVSTAYYLSKNSNLHSESKITLVEQDNVGAGNSGYASGLLERTEDELSQEGFDLHYKLSKDYKGDLKWGYKSIDLYKTTSHSSSSSSSSLSSSIITFPFLPSTSLIRTKTETAICQPFDLTRHLCGLFLTYPGASIVIAKATSCIFEDEVEVENNEKEEKGISDMILNHTPCIEKITQFFNGTDKEDNKNDNDNEKEENEKINNNEKIRKRKIKGINVKQIINGVEEIIHLKANTLILSPGNDLINLSKNLFGEEISLNLKIKKKEWESIILKPKEKLNPLVIKFDENKQNLEMIFRDDGKVIISRPFQENSLNSYIESISSKFNSSNGTLILSKTNWSISFLSDNFPLFGKFGEELDIDGIWYGIGGNTVQCPAIGSRLASEVLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HYP7</accession>
    <name>A0A1B9HYP7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial Rho GTPase</fullName>
            <ecNumber evidence="15">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">I206_05182</name>
        <name evidence="20" type="ORF">I206_107273</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="20" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 15">Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Mitochondrion outer membrane</location>
            <topology evidence="2 15">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the mitochondrial Rho GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="15"/>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC73306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009624.1">
        <property type="nucleotide sequence ID" value="XM_019156906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HYP7"/>
    <dbReference type="STRING" id="1296096.A0A1B9HYP7"/>
    <dbReference type="GeneID" id="30173551"/>
    <dbReference type="KEGG" id="kpin:30173551"/>
    <dbReference type="OrthoDB" id="10020961at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01893">
        <property type="entry name" value="Miro1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01892">
        <property type="entry name" value="Miro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000011">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000553">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000277">
        <property type="entry name" value="Mitochondrial Rho GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001330">
        <property type="entry name" value="Mitochondrial Rho GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013566">
        <property type="entry name" value="EF_hand_assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013567">
        <property type="entry name" value="EF_hand_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021181">
        <property type="entry name" value="Miro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052266">
        <property type="entry name" value="Miro-EF-hand_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020860">
        <property type="entry name" value="MIRO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819:SF1">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08355">
        <property type="entry name" value="EF_assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08356">
        <property type="entry name" value="EF_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037488">
        <property type="entry name" value="Mt_Rho_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
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                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
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                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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                <person name="David-Palma M."/>
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                <person name="Mohammad A.W."/>
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                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
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                <person name="Cuomo C.A."/>
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    <reference evidence="3" key="2">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF260">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="67"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF48542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC73169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="483" mass="52546" checksum="DA64CC9651613718" modified="2016-11-02" version="1">MSSSKNEVGLPPVGMENSSISNLKLIDNVLGLPIESGMSMSHWLGTVRNNPLLDLRSSEKLPASAEVVIIGSGISGALTALNLLESRTPPNSIVMLEARELCSGATGRNAGHCKPDLWRGFTEYAKRFGNDQALKILANEKETREALVKFIEDNKIQCEVWNGKTMDVMMDNTVVEKAAETMKAFKAAGGDASFIDVILNPAEAEDISRVKGAKAVYASPASTLHPWKLVEFVIKRCLRLGLNVQTLTPVTSISGSNNKWIIHTDRGDIRTSTVIHNTNAYAGYLLPETKKSITPIPHMCNLVYPPSSHSGSKGLSNSYAVIYTEGLFSINPRSTSDGAILFGGVQPAQDALESFVKEKAERQYDDRLKDFQPITECVKTLGGNVFDWDKPPKPGFAVRYDRSWSGIIGLSSDEVPFVGAVPGKAGQWMSCGHNGHGMARIFTCSRGLAKLVQGSSWVETGLPECFQVTRERLNGQAFRPSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HZ85</accession>
    <name>A0A1B9HZ85_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_05383</name>
        <name evidence="3" type="ORF">I206_107073</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC73108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009822.1">
        <property type="nucleotide sequence ID" value="XM_019157104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HZ85"/>
    <dbReference type="GeneID" id="30173752"/>
    <dbReference type="KEGG" id="kpin:30173752"/>
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    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF48603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC73108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="410" mass="46247" checksum="1E52009E2C36397F" modified="2016-11-02" version="1">MGGSRIRKSEPYEHDWTENQICLVLDKISNSKNLVKIFFNKQGIESPSSILAEQELCIELLGSTSWITYMIQNKRVIRDSNGLLRLKSEQWPKRLRVISKLFDFVHPSAEKIRNQLGPYHSVVDLNLYNSDGYKQWKEWQAQGQNTWYFKYVFIKQHIDPKWLKRNISSPSSTTGMETASRREYNPINTSQYPREAPPHLRGTRATYTTTDSSKIDISMNDIEMTLPLSSHTPSSTPSIPAYLPPTPISAPRGQGYPAPTHHNDLTGGTQRDSEENKITGREEFIAAMLVLISQELNHRPSSCMAGCSIIHNKAISISEQSVLYLIKKLGGNIINASTTSIQDTLKDKKQDTSTAFILWSTEDDYLSGPIGLDREKGDSPTPITLVGLVHLIIAKRKIELGEGQIDLLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HZE8</accession>
    <name>A0A1B9HZE8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP synthase subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I206_05391</name>
        <name evidence="17" type="ORF">I206_107065</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC73100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009830.1">
        <property type="nucleotide sequence ID" value="XM_019157112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HZE8"/>
    <dbReference type="STRING" id="1296096.A0A1B9HZE8"/>
    <dbReference type="GeneID" id="30173760"/>
    <dbReference type="KEGG" id="kpin:30173760"/>
    <dbReference type="OrthoDB" id="9805536at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18116">
        <property type="entry name" value="ATP-synt_F1_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1-ATPase_alpha_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.150.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004039">
        <property type="entry name" value="ATP synthase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="entry name" value="ATP synthase alpha/beta chain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a_nt-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009884">
        <property type="entry name" value="PRK13343.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082:SF2">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039088">
        <property type="entry name" value="F_ATPase_subunit_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="15">
        <location>
            <begin position="56"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="13">
        <location>
            <begin position="180"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase alpha subunit C-terminal" evidence="14">
        <location>
            <begin position="410"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCF48611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="WWC73100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="540" mass="58023" checksum="7E902CDE315EB8C9" modified="2016-11-02" version="1">MRVAFRNTLRGAVASSARTRAAPLAARTYATAKPAASEVSSILEGRIAGASVGGDVQETGRVLTIGDGIARVYGLRNVQAEEMVEFSSGVRGMCLNLEADNVGVTIFGNDRLIKEGDTVKRTGQIVDVPVGPGLLGRVVDALGNPIDGRGPIESVGRTLAQLKAPGILPRRSVHEPMQTGLKSVDSLVPIGRGQRELIIGDRQTGKSAVAIDTILNQKKWNDGADESKKLYCVYVAVGQKRSTVAQLVQTLEENDAMKYSIIVAATASEAAPLQYLAPFSGCAMGEWFRDNGKHALIIYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLNADYGSGSLTALPIIETQGGDVSAYIPTNVISITDGQIFLEAELFFKGVRPAINVGLSVSRVGSAAQTKLMKSVAGSLKLYLAQYREVAAFAQFGSDLDASTRYLLNRGARLTELLKQPQYQPMPTEIMAPLIYAGVNGKLDKVAVDQIGAWEKSFTDLLKSQHSALLEKLSGGVLTKEIEEEMAKVIDAHVADFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HZF3</accession>
    <name>A0A1B9HZF3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mitogen-activated protein kinase organizer 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_05425</name>
        <name evidence="8" type="ORF">I206_107032</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat MORG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC73067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009864.1">
        <property type="nucleotide sequence ID" value="XM_019157146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HZF3"/>
    <dbReference type="STRING" id="1296096.A0A1B9HZF3"/>
    <dbReference type="GeneID" id="30173794"/>
    <dbReference type="KEGG" id="kpin:30173794"/>
    <dbReference type="OrthoDB" id="1068471at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051980">
        <property type="entry name" value="WD_repeat_MORG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842:SF3">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING PROTEIN 83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="24"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="66"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="108"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="288"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCF48645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC73067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="321" mass="35439" checksum="E3170E1BB3DC0C09" modified="2016-11-02" version="1">MAPSRGEEEVQQDFSYPSKLVQTLDAHSGPVNVIKYNHGAKYLLSGSTDRSIRLWNPALGKEIKCYNGHAQEVLALDITHDNAKFASSGGDRAVFLWDVPTGSVIRRMQGHFGKINAVAFSPDSQVLASAGFDAKVMLWDMRASSRDPLQTLKEAKSTVSSIILPNSPQIITGSYDGFLRTYDLRFGLITDDLIGEPINTIKLSNVNPEESILISTNLENTEKNISKIRIFDRKDGSCLQTFSGNEIVPNRWGINWGYGESCVLAGDKDGGLSSWNVLNGKQLPDHPKQIHKKQITSIELNPRGKEMITASLDGSIKVWHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HZM6</accession>
    <name>A0A1B9HZM6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphoglycerate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_05503</name>
        <name evidence="7" type="ORF">I206_106955</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
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        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
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        <property type="protein sequence ID" value="OCF48722.1"/>
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    <dbReference type="STRING" id="1296096.A0A1B9HZM6"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:NAD binding"/>
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        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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    <dbReference type="PANTHER" id="PTHR10996:SF264">
        <property type="entry name" value="HYPOTHETICAL D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE (EUROFUNG)"/>
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        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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            <end position="360"/>
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            <end position="329"/>
        </location>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCF48722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC72991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="39992" checksum="C9F3BDA6A09ABB62" modified="2016-11-02" version="1">MTYLPTPPSEPNSDRGTKTKTETEIEIKSKSNISSKEATIYLHTPFHPKAEEYAKSKFGKIIRPEDENFNEIFPQTDGILLRVGNLTRDMILKANKLQIISRNGVGIDNIHIETAKERGITITNCPGGNAQAVAELALTLTLTLLRRVVEIDNRIRLGEKVTSIKALSPGLFGKTIGLIGMGDISYEFSKLLLSFNCKILIYSPTSNLKKWTLEDDPNSKYSSFIIPHKRILNLNELLKNSDVISIHCPLNEKTKGLIGKEEFKKMKKNSIIINTARGGIINERELENALENNLISGAGIDVWEIEPAFGDTMGKLGKLKNTVVLPHLGGSTDSVTLEGCMTAIDIMADYFDGKPIKNRVI</sequence>
</entry>
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    <name>A0A1B9HZN6_9TREE</name>
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        <name evidence="3" type="ORF">I206_106944</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC72980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009951.1">
        <property type="nucleotide sequence ID" value="XM_019157233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HZN6"/>
    <dbReference type="STRING" id="1296096.A0A1B9HZN6"/>
    <dbReference type="GeneID" id="30173882"/>
    <dbReference type="KEGG" id="kpin:30173882"/>
    <dbReference type="OrthoDB" id="2563633at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF48732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC72980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="162" mass="18504" checksum="1B5852F4541446AD" modified="2016-11-02" version="1">MSSDPSGSIVRKAFLIEAFLNLLSFPLITNTKTTLYYLLLNSKDINESTILFTRLFGGIIIGGLTTSLIYGSKYINSRRNTYYTLGFGEILLIPILSLELFKSLEEKNQSALSFKTSLISICLLLPPLIWRIYILFIRPDLIGNEKELKKLERQPLLRDDQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I020</accession>
    <name>A0A1B9I020_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_05653</name>
        <name evidence="4" type="ORF">I206_106799</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Sykes S."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
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            <strain evidence="3">CBS 10737</strain>
        </source>
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            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
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                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
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                <person name="Nusbaum C."/>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 10737</strain>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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            <strain evidence="2">CBS 10737</strain>
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            <dbReference type="EMBL" id="WWC71831.1"/>
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            <dbReference type="Proteomes" id="UP000094020"/>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
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                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
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                <person name="Goldberg J."/>
                <person name="Griggs A."/>
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                <person name="Hansen M."/>
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                <person name="Imamovic A."/>
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    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Saif S."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
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            <dbReference type="ChEBI" id="CHEBI:57783"/>
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            <dbReference type="ChEBI" id="CHEBI:85101"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
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        <reaction evidence="5">
            <text>a (2E,4Z)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:61892"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85099"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="1.3.1.124" evidence="3"/>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC71965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010279.1">
        <property type="nucleotide sequence ID" value="XM_019156477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I0J8"/>
    <dbReference type="STRING" id="1296096.A0A1B9I0J8"/>
    <dbReference type="GeneID" id="30173116"/>
    <dbReference type="KEGG" id="kpin:30173116"/>
    <dbReference type="OrthoDB" id="2136131at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008670">
        <property type="term" value="F:2,4-dienoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05369">
        <property type="entry name" value="TER_DECR_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045017">
        <property type="entry name" value="DECR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE [(3E)-ENOYL-COA-PRODUCING]"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
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    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048009"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCF49060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC71965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="289" mass="30765" checksum="8E2A2CD87C0264D7" modified="2016-11-02" version="1">MLSSGSHKANASNVFRQDLFKGKILFCTGGRSGICYQIVETMMSHGVDAVIVGRDAKGLAESAQALEKSTGQRCLPASADVRDPKQMEQAVKQTIEKFGRIDFVICGAAGNFLAPISSLSTNAFKTVIDIDLLGTYNTIKATIAHIRKSKGSYIHISATLHYRGLPYQAHVSAAKAGVDALSSVLAVEEGPRGVRSNVIAPGPIGNTEGMSRLTPKGWKPENDIPLGRMGNTSDIANAAVFLFSPAASYITGTITVVDGGEHHIRQMSLPYPQSLLDPESVKNLIKGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I0M8</accession>
    <name>A0A1B9I0M8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cation-transporting P-type ATPase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_04777</name>
        <name evidence="13" type="ORF">I206_105954</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC71995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010309.1">
        <property type="nucleotide sequence ID" value="XM_019156507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I0M8"/>
    <dbReference type="STRING" id="1296096.A0A1B9I0M8"/>
    <dbReference type="GeneID" id="30173146"/>
    <dbReference type="KEGG" id="kpin:30173146"/>
    <dbReference type="OrthoDB" id="158672at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000083">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF21">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="932"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="992"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1031"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1062"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="11">
        <location>
            <begin position="99"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCF49090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC71995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1101" mass="122156" checksum="D12840CCB013114A" modified="2016-11-02" version="1">MTLPDDIERDGAIDKKSFDTESRPHHTPTLLKSVTIRDANQDNTLGLDRMNRATRSRRDSASRMIGEFRTLSIDVTDTQQRQAAAVVQKGAAKEIAELEWHKYSVVDILQRLSVNDKVGLEDEQVKRKSSQYGLNEINPPKPNLFLKWLEYVLGGFGSLLLIASILCFIAWKPLGEPNPAPANLALAIVLLIVIIVQTAFNAWQDFSTNRVMASISGLLPSAVLVLRNSVQSQLAAKELVPGDIIYVSLGNKLPADIRFIDVSSDLKMDRSVLTGESEPIQATIDMTDENLLETKNIGMQGTLCVSGSGVGVVVQTGNLTVFGRIAKLSSTGAPSLTTLQKEILRFVLIIVVCALTIATIVIILWATWLNKKHKGFITVPTLIIDVVSVCVAFIPEGLPASVTISLAVIAKKLVNNKVLCKSLMTVETLGSVNVLCSDKTGTLTENKMTVTNLACLDDEMDLTQARDRIITGKDKNNVVSQMAAIMGICNAAQFDESTNDQPITLRKVNGDATDSAILRGAESLRPVKESLSEWTEIFKINFNSKTKYMLKLCRRASAKSPLFPAPCDSYNEFGPDDLMLMCKGAPDVLLKRCSHVNDPSGGPPLPLTEETISKLTAVQEKWASKGQRVLLLAKRIIPRSSIPKEYSFNQPEFSDFINTDLNQQLTIVGLVGLVDPPREDIPNTVRIMREAGIRFFMVTGDFALTAISIAKQCGIITSNNLHYLKDLPRTLEQIKLYDREELNVTPGLVLTGNDLMEMNDCQWEQICQYTEIVFSRTTPEQKLRIVKEFQKRENVVAMTGDGVNDAPSLKAANVGIAMGGGSDVAMEAADLILLESFSSIVVAVEYGRLVFDNLKKTCLYLLPAGSFSELMPILLNVLLGLPQILSSLQMIIICVVTDVLPAISMCFEKPEAGLLNRPPRNTKKDKLVDWKFLLHAYGFLGLLESLAAMSMSFWWLNKEGFKFSDLVLAYGGLPPQYDPDAYAEAISKAQSIYFFTLVGMQFGNLLATRTRRLSILQFNPFKWSDENKRNYWIIPSMIASIVFLFFFSYVPFFQHTFLTRGVPVEHIFIPFTFAIGLLLLDETRKFFVRRYPKGLLARIAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I150</accession>
    <name>A0A1B9I150_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerophosphoryl diester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_04876</name>
        <name evidence="4" type="ORF">I206_106053</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010407.1">
        <property type="nucleotide sequence ID" value="XM_019156605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I150"/>
    <dbReference type="STRING" id="1296096.A0A1B9I150"/>
    <dbReference type="GeneID" id="30173245"/>
    <dbReference type="KEGG" id="kpin:30173245"/>
    <dbReference type="OrthoDB" id="1058301at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08570">
        <property type="entry name" value="GDPD_YPL206cp_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43805">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43805:SF1">
        <property type="entry name" value="GP-PDE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="2">
        <location>
            <begin position="12"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF49188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC72093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="379" mass="42718" checksum="E4D249584689366E" modified="2016-11-02" version="1">MSPIPFRKPKEIECWGHRGASAHLPENTLASFRAAIKEGCNGIESDVHATSDGVVLMFHDPTLDRTTNGKGLIKNQPWNGVIENVRTIKEPIQPIPLFEELIALLMEPENQHVTLNIDCKMQNDPERLFPQMARIISKYPDNARTLCPRIILGLWHPLFIQPAYKYLSNCTRYHIGFSIPIIKSYFWKYCQGFSICFPILMSNEGQNFLKECRENGKEVTVWTVNDENEMRTAISWGIKAVLTDRVGKFVELKQAIIENPSEMNITGLSKLTFPWSSWRYYSVAHVTIRSLGAMYLKAHGQLYDPFIDSNLPSSSSTENDNILSFSSSYSPPLAASSPTLIPTSPETDDSSSKSTTGNSTIRRLSLSISPEFLIRENPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I194</accession>
    <name>A0A1B9I194_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_04983</name>
        <name evidence="3" type="ORF">I206_106158</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010513.1">
        <property type="nucleotide sequence ID" value="XM_019156711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I194"/>
    <dbReference type="GeneID" id="30173352"/>
    <dbReference type="KEGG" id="kpin:30173352"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF49294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC72198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="112" mass="12573" checksum="DF5956D8A67F4A3D" modified="2016-11-02" version="1">MSSESGISNIQPSITEDMSMDGKFDEMFGYNTYVLNRWRDPTDIPEDVQAALQKNNSSIIIDEVSETAHRKGMKRQWQEQMEKFRSAGILGTNLAESSSDQTFDGFAGEPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I1M5</accession>
    <name>A0A1B9I1M5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NAD-dependent protein deacetylase</fullName>
            <ecNumber evidence="9">2.3.1.286</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I206_05051</name>
        <name evidence="17" type="ORF">I206_106225</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-acetyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-acetyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:43636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="ChEBI" id="CHEBI:83767"/>
            <dbReference type="EC" id="2.3.1.286"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="9"/>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010577.1">
        <property type="nucleotide sequence ID" value="XM_019156775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I1M5"/>
    <dbReference type="STRING" id="1296096.A0A1B9I1M5"/>
    <dbReference type="GeneID" id="30173420"/>
    <dbReference type="KEGG" id="kpin:30173420"/>
    <dbReference type="OrthoDB" id="420264at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017328">
        <property type="entry name" value="Sirtuin_class_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF6">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037938">
        <property type="entry name" value="SIR2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 9 11" id="KW-0520">NAD</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 9 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="15">
        <location>
            <begin position="55"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="19"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="378"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10 13">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="83"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="93"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="165"/>
            <end position="168"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 13">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 13">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 13">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="277"/>
            <end position="278"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="301"/>
            <end position="303"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR037938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCF49358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="WWC72263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="398" mass="45956" checksum="CF241852163137AA" modified="2016-11-02" version="1">MMTLKYWMNRTGEINIHENDDSTFVSSDKEDSDSEESFSSHSSSPIPITNLDNLKINNSECIKKVSNLIKLGKAKNIILLLGAGISTSAGIPDFRSPKTGLYNNLKKFNLPFPELIFELNYFKKNPKPFWELAKEIYPGKYFPTPTHYFLNLLNKKNLLKRIFTQNIDTLENLTGLNENLIIESHGSFSKSHCLKCKKEIKREKILKDGLRKGKVIKCDYFINENENENENENEKNQQKCNGLVKPDIVFFGENLPDRFFKFLPDLKECDLLIIIGTSLQVQPFASLIDKVPLNCPRLLINREPVGPFTQIKLNEKRDMYYKGDSDKGIYELSEELGWKDELNELIESGNKKLKIRYEESESENTIKNKLDTTLKEGFEDETEEADELEEAMKKQLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I1P2</accession>
    <name>A0A1B9I1P2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Class II aldolase/adducin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_03970</name>
        <name evidence="3" type="ORF">I206_104449</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Abouelleil A."/>
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                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
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                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Murphy C."/>
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                <person name="Roberts A."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
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                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Imamovic A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="5">CBS 10737</strain>
        </source>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
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                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">CBS 10737</strain>
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    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        <subcellularLocation>
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            <location evidence="2">Nucleoplasm</location>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_019155831.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A1B9I1Z2"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="U1 small nuclear ribonucleoprotein 70 kDa"/>
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        <property type="entry name" value="RRM_dom"/>
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    <dbReference type="InterPro" id="IPR051183">
        <property type="entry name" value="U1_U11-U12_snRNP_70-35kDa"/>
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    <dbReference type="InterPro" id="IPR022023">
        <property type="entry name" value="U1snRNP70_N"/>
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    <dbReference type="PANTHER" id="PTHR13952">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KD"/>
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    <dbReference type="PANTHER" id="PTHR13952:SF5">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KDA"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="RNA-binding domain, RBD"/>
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        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="163"/>
            <end position="240"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="8">
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    <feature type="region of interest" description="Disordered" evidence="8">
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I253</accession>
    <name>A0A1B9I253_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_04144</name>
        <name evidence="7" type="ORF">I206_104280</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1296096.A0A1B9I253"/>
    <dbReference type="GeneID" id="30172513"/>
    <dbReference type="KEGG" id="kpin:30172513"/>
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    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="MFS"/>
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        <property type="entry name" value="MFS_trans_sf"/>
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    <dbReference type="InterPro" id="IPR050375">
        <property type="entry name" value="MFS_TsgA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702">
        <property type="entry name" value="L-FUCOSE-PROTON SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702:SF13">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
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                <person name="Litvintseva A."/>
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                <person name="Mohammad A.W."/>
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    <dbReference type="InterPro" id="IPR045154">
        <property type="entry name" value="PCF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054127">
        <property type="entry name" value="Pcf11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047415">
        <property type="entry name" value="Pcf11_CID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921:SF3">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX 2 PROTEIN PCF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21936">
        <property type="entry name" value="Pcf11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="31"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="688"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="701"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF49752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC70199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="726" mass="81489" checksum="3B04937A531DB3A5" modified="2016-11-02" version="1">MSYQAYPPYQQQIPQQGGQGSYYPPSHVVPPHDPFRAYYSDRLRQLTFNSRPIIQDLSMMAGAQRDQNNWEGMNMIVQEIEEATLRALPTQKLPLLYLIDSISKNIGPPYTTHLLPPIIPRLYLRTYREVDGVTKAKMEEMINLWRSGGPNRTELYPNGVREQIERDIFGSSYSSSSNGNGNGVGIINNFPTLQQVKQTVQNALDKKQREAASKAWDLPTGQQVNALTGILNLLNSTNVSPQELNQIMEQVKSIDLTLQSTSVNPIRQPVFSPQPPPSAHLSTPNWNQPPPVTPVSQNPSITPFQRQPIPQSVNVRPPFISAPTPQANLNTPIPGSTTPVPVPSVPIPTITNLPIDVSKILNSLNKSGIVSQNRTPEPEPQVKVTVEKSPLEVYEDYIINLNLSLRNIDLNAPNKLSFNHLPHRCKQCGMRFASDGPKFQAHMDWHFRRNRKERESVGRGSHRRWLVRSYEWINDTYTSNAEAGPSNTVNSPGKSNTSLKGTISLERMNQLKEKWVKVPQDTKKASSICPVCKEAFVKEWSEDEEEWIWKNALNINGTYYHATCRAEQLSAMRRLKGSDPNKRSTSGSPRLTTTPQPPDVTAQTQNPLSMQIKNENLEVPSSTTASPQSQKRKAEEDDLENGNKVEDGLESKRVKVELESQTTEVVENDLQGNQDISPIIKEERIEEHISGNDEQVDENGSLETQADTQQTDNSEIENVVLETTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I364</accession>
    <name>A0A1B9I364_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Inosine triphosphate pyrophosphatase</fullName>
            <shortName evidence="10">ITPase</shortName>
            <shortName evidence="10">Inosine triphosphatase</shortName>
            <ecNumber evidence="10">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="10">NTPase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">XTP/dITP diphosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_04439</name>
        <name evidence="13" type="ORF">I206_103987</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ITP + H2O = IMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>XTP + H2O = XMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10">Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10 11">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="10"/>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011127.1">
        <property type="nucleotide sequence ID" value="XM_019156169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I364"/>
    <dbReference type="STRING" id="1296096.A0A1B9I364"/>
    <dbReference type="GeneID" id="30172808"/>
    <dbReference type="KEGG" id="kpin:30172808"/>
    <dbReference type="OrthoDB" id="6288734at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009204">
        <property type="term" value="P:deoxyribonucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.950.10:FF:000009">
        <property type="entry name" value="Inosine triphosphate pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03148">
        <property type="entry name" value="HAM1_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027502">
        <property type="entry name" value="ITPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="RdgB/HAM1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00042">
        <property type="entry name" value="RdgB/HAM1 family non-canonical purine NTP pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067:SF9">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE/HAM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 10" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="67"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="143"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="173"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
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                <person name="Litvintseva A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
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                <person name="Sun S."/>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="David-Palma M."/>
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                <person name="Bowers K."/>
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                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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    <sequence length="709" mass="77833" checksum="D25121E5901D4DA2" modified="2016-11-02" version="1">MGQQNSRLEYDSTLSQTHQPQPAFTSLDPDPFHHSPPNQEPYQLSQQPISPAFYDAPHSAPVVPVSSKPKGLIRSLSAKRRGESRHINTSQSQFRQPELPPLGSLKALKTLGAQGADLKSSMREFEVLVQKAEISAGIRSPSPITLNDSNYETSSTFPRRSSKSPRENGSISEENFIKLREGNNSPLPKLSVTPAYLRPAPFRRNSCSSSIHSTRVSIKSARRAEREWRAKVAALSSGLSPHTQINTSPIRVNSKTKGGPVPPRRNNRSTSPGIYLTSMTNRSTSPEEGTVIITPPHSMTTAVSFGTPLSNKSFETLGHYPNSSITESPTPISTYTDNVRERKPSVPHSAYSITCSTIKDEDELGRPISLASGQWLAPSALQPSPVKVKINTAVDDTGDRYTPNSLYVNGTSTPTSPHHDNLPPLESFKSSPRMVNSQVLPLVETPKKNGNAQIEREEIERKHLSLPSPPRPNATPTRRPSLHIPTLNIPNTPPCLPPLTFSPSSVELTTPRNKPLTTPTKLSPIVKEPSTPYSPTTAHILTASSPSIDQMAYSSFVNSPQRQNERDPITPIRRHPFTFGAEPSPEPSNQCSPELEIKNESILPDKFDPKYEKGGMAIPRRSSIDPFIPRQLPSTTRNSALTLRSQGNIQNIPSIKNNVIGNNVREEAGLKRLMKAKIDLTPGMENGCRPPKSGLPMADLERWLRNASM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I3J6</accession>
    <name>A0A1B9I3J6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosomal protein/NADH dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_03417</name>
        <name evidence="5" type="ORF">I206_105681</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011319.1">
        <property type="nucleotide sequence ID" value="XM_019155165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I3J6"/>
    <dbReference type="STRING" id="1296096.A0A1B9I3J6"/>
    <dbReference type="GeneID" id="30171786"/>
    <dbReference type="KEGG" id="kpin:30171786"/>
    <dbReference type="OrthoDB" id="1696305at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="3">
        <location>
            <begin position="45"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF50100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC71723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="151" mass="16789" checksum="6C02ED33F247C159" modified="2016-11-02" version="1">MASSIASTSLRRLPFKEAINLLRNGNDNLILSNDIKSITIKFIAKNSESGPRQFLKNHLPKISYINPKIEIKINRLPDPRSKSKDPKLIKINKEINWENGIMPKPEMEIGFVGAPSQTVPLSHLDGDKILAQLISVAGEERVRAVDGPNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I488</accession>
    <name>A0A1B9I488_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RecQ-mediated genome instability protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_03655</name>
        <name evidence="7" type="ORF">I206_105439</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011555.1">
        <property type="nucleotide sequence ID" value="XM_019155401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I488"/>
    <dbReference type="STRING" id="1296096.A0A1B9I488"/>
    <dbReference type="GeneID" id="30172024"/>
    <dbReference type="KEGG" id="kpin:30172024"/>
    <dbReference type="OrthoDB" id="341511at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.770">
        <property type="entry name" value="RecQ-mediated genome instability protein Rmi1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049363">
        <property type="entry name" value="RMI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042470">
        <property type="entry name" value="RMI1_N_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013894">
        <property type="entry name" value="RMI1_OB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790:SF15">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1 RMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08585">
        <property type="entry name" value="RMI1_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21000">
        <property type="entry name" value="RMI1_N_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01161">
        <property type="entry name" value="DUF1767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RMI1 N-terminal" evidence="5">
        <location>
            <begin position="11"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="RecQ mediated genome instability protein 1 OB-fold" evidence="4">
        <location>
            <begin position="70"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="219"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="440"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="526"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="526"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCF50336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC71481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="558" mass="64073" checksum="E8281DA64DF45DA4" modified="2016-11-02" version="1">MMDTQPIVSFLKRTYPNPEVDPVWVQECTRALLEAGQEVTIDTVHTQFLYSDLAQSTLASRTFPSGDLHEKILFQRPTILQMHHISEIGHSAFQIKHTMEQRSEVLSGQSLIRRMEDEVVEDEQEQNIDQGKVPPYPRSMLKLELSDGRRIIKAMEYKKINNLVLGQTSLGCKVVCNNVKCLRDTLLLTPQNTQVLESSVEYLELTQKEEFMKDLNRRMGKLDDGSTNIPAQRRIKPPPPIRPKHNASIKPPAAQIRSKITHSPEIIPTAGPSRTSHYFQSNPAEQVHPPHLVRPKPIRAQGLKSSSSASNSRKRSMNDDSEDEEEPISKSRRSRTAAKLATAKVTQLYHDIPDDKFTEMDEDFGNENDDEFDYDIDESFIRQINEVEAKASGSGIYYKNFKSHKYNDVEEEEEDDDDDDDFMIIDEKIIKQIDNLSSSSFSNQNKGIGKEKENQNQNRKNYINQDNLNDEKEILSTEDDEFELQLDDKFIKNLNEIEFKQNKKDKDNYKSFQNKNNRLFSLSLSRSNSDSLISNSNSNSINNSQKENIQPEIIEISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I492</accession>
    <name>A0A1B9I492_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">U3 small nucleolar RNA-associated protein 25</fullName>
            <shortName evidence="7">U3 snoRNA-associated protein 25</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_03664</name>
        <name evidence="12" type="ORF">I206_105430</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
            <location evidence="2 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the UTP25 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011564.1">
        <property type="nucleotide sequence ID" value="XM_019155410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I492"/>
    <dbReference type="STRING" id="1296096.A0A1B9I492"/>
    <dbReference type="GeneID" id="30172033"/>
    <dbReference type="KEGG" id="kpin:30172033"/>
    <dbReference type="OrthoDB" id="10264378at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010678">
        <property type="entry name" value="UTP25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053939">
        <property type="entry name" value="UTP25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053940">
        <property type="entry name" value="UTP25_NTPase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933">
        <property type="entry name" value="ORF PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06862">
        <property type="entry name" value="Utp25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22916">
        <property type="entry name" value="UTP25_NTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="UTP25 NTP hydrolase-like" evidence="10">
        <location>
            <begin position="234"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="UTP25 C-terminal" evidence="9">
        <location>
            <begin position="510"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="18"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCF50345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC71472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="710" mass="79357" checksum="68057E2FC35D2D34" modified="2016-11-02" version="1">MSTAQEIKLLTLLNVSAVKRPRELDLPGGHRGSPSFSKTPSLVPESEDGKEPKKRRKSVVFGGEVGPSGSTYGKGKGKGKAKKIEETPVVNGTKNAEEIPVNGNDEVFEEEGESDDEGEASSSANDDLFNVHFGPTPSILTKENISLSEGNKWKAERKSLKGFGRAVELSAGSSVSNEQLKTRITPTISASLKASASTNPLLSTSLSHLGTYKDLYLHSLDGEADGAETQVLGKHKEAMRQAAIIHALNHVMKTRRKIIRNNEKLAHAASSDNPSSIPEPPRDQSFTRPKILLLLPFRSLALHYIKTHLLPLAPAGTQIENQRPFSSSFALPEDEEDPLASTSAHDDFPIDHLVNFRGNSDDNFRFGIKFTRKAWRIVMPPANEEKLLDCDILVSSPLGFKMAAEKEDSTDLLSSIEILIADGLDTMAMQNWEHVQFIFNNLNKIPKSPHGCDFSRVKPWYLESQAQYLRQTILLSRYDTPEIRAIFNRNCQNLQGKIRLEKVDYHGVLDLVKPGVRQVFERIDLDTPKVLNGEAAVEEVDKRLEWFTKKTIPALLRSAISRQNTLIVVPSYFDFVRLNNYLRKNDVTTYAAISEYSSNSEISKARTLFFKGKKAFLIVTERLHFYRRYKIRGAKTVVFYSLPDHAQFYSEFMNTPFLGSKGQGEVEVDEAEVSSRVLFSKFDALKLERVVGSTNARRLLTSGEGRLEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I4H1</accession>
    <name>A0A1B9I4H1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_03745</name>
        <name evidence="4" type="ORF">I206_105345</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011642.1">
        <property type="nucleotide sequence ID" value="XM_019155488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I4H1"/>
    <dbReference type="STRING" id="1296096.A0A1B9I4H1"/>
    <dbReference type="GeneID" id="30172114"/>
    <dbReference type="KEGG" id="kpin:30172114"/>
    <dbReference type="OrthoDB" id="21617at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="7"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF50423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC71390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="295" mass="32774" checksum="F8409EEE760BF151" modified="2016-11-02" version="1">MTYPDNSASSVNSLLALLRSAQDGSTPSISPSTSSQNPTQPSHRSPIQAQTSSTKPNIPSKRQLDDLLSSLNARAPTGKQERLIEPFGPVGEITSPSKPLYDPQNQYSSSSRPQSDTSADNFGRKGKQSTERNANNTPTPPKTKLKPFERINEQGYAFISFSKALPILSELLEDDNFKIELKKMKKEQDALERRLWAKREKIKAEHEKTIQAEKEIAKIARKVVPLEKKEAWARTLSSTLSTFYLQQCLQATDGLASKQRQILIELGVPGLGDDGEKGKDRVKRIMELLEAGLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I5H1</accession>
    <name>A0A1B9I5H1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_02825</name>
        <name evidence="4" type="ORF">I206_102474</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF50769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011988.1">
        <property type="nucleotide sequence ID" value="XM_019154585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I5H1"/>
    <dbReference type="STRING" id="1296096.A0A1B9I5H1"/>
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    <dbReference type="KEGG" id="kpin:30171194"/>
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    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45570">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45570:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628352" description="Carboxylesterase type B domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="78"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF50769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC68545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="578" mass="63731" checksum="6F12232563DDF1C4" modified="2016-11-02" version="1">MTILFISLSILIFIRIISSQSIWDNSNRISDDELCLISILGITVKGLLTNEGACRYTVKYGISKRWKESYSTLNDLNDQQSFNNLPPSCPQKEGTYVSGDYQSEDCLFAIIYSPSSINSLLKLPILVWIHGGSYTAGSASSPGLDGSKLAIRGNMIVIILQYRLGILGFLPPYSSDSWSDPNLGLRDVILALKSIQNGIEFVGGDKDKVTIGGQSSGASIARALLGAPEAKGLFRAAILQSDPMSYGNSPNDITSKLRDLYYSQEPLKSCTNIECLENVPHASIIAAQDDLTLSAPMLIKGIPLPMVIRPTFDNPTLPSDPTLSLFSNPTSLPLWNISILLTTVKNEAGSAVSDLFPNPVPLSFDTYYATLSASINTYRANQLATSKEYALLDNTGFGKGGDEFREKYETAATDGIWKCPNRDVASIWRKNGGNVWVGEWTKGSTYPSNKDHAYCTIKGKVCHEDDIYPTFGNSPNTTIETTSIEDEVLSYWSNFIINLDPSSSINEQTIRHESIKNWFGWLWSPKKSFQSPSLRASSEWSMYRSFEDVFTIGGGQASSCPEGFWGKKVEYDWQIYGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1B9I5Q0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_02899</name>
        <name evidence="3" type="ORF">I206_102548</name>
    </gene>
    <organism evidence="2">
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        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF50842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012061.1">
        <property type="nucleotide sequence ID" value="XM_019154658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I5Q0"/>
    <dbReference type="STRING" id="1296096.A0A1B9I5Q0"/>
    <dbReference type="GeneID" id="30171268"/>
    <dbReference type="KEGG" id="kpin:30171268"/>
    <dbReference type="OrthoDB" id="506498at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="39"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF50842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC68618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="269" mass="29710" checksum="2A94EF221B8AC3E2" modified="2016-11-02" version="1">MKHHSKTTPCAPCNFHLLNIAELPPDLKLTQTLVFDFAGTWAIEVANTHSFSDVLGVDINWGMMTHNTRSRYGNLDFAAVDVEEPLPWPRGSFDVIHVKGLLLEISHYTRLIEKLAMVLRPGGLLAIVEIDPNHVSADGHQLPKCLRQWDACVRSALGGRGVDIDFPSRIGSVIANAGVFASNPYSQYLGVPASSHISRGDVNSAARSGQIHHQLLIANLRKTFSALVEYGYNRPDLEDMFSSCLAELTNPNATYVHRLYAVYATKAYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I5Z1</accession>
    <name>A0A1B9I5Z1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amine oxidase</fullName>
            <ecNumber evidence="5">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_03005</name>
        <name evidence="9" type="ORF">I206_102652</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="5"/>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF50943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="1296096.A0A1B9I5Z1"/>
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    <dbReference type="KEGG" id="kpin:30171374"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF386">
        <property type="entry name" value="LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="142"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="35"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="244"/>
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        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601613-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF50943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC68718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I605</accession>
    <name>A0A1B9I605_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Vacuolar import and degradation protein 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_02983</name>
        <name evidence="13" type="ORF">I206_102630</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF50921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012140.1">
        <property type="nucleotide sequence ID" value="XM_019154737.1"/>
    </dbReference>
    <dbReference type="STRING" id="1296096.A0A1B9I605"/>
    <dbReference type="GeneID" id="30171352"/>
    <dbReference type="KEGG" id="kpin:30171352"/>
    <dbReference type="OrthoDB" id="5364245at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46459:SF1">
        <property type="entry name" value="E1A-BINDING PROTEIN P400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46459">
        <property type="entry name" value="E1A-BINDING PROTEIN P400-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07529">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00573">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
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                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
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                <person name="Griggs A."/>
                <person name="Gujja S."/>
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                <person name="Imamovic A."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
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                <person name="Dewar J."/>
                <person name="Goldberg J."/>
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                <person name="Imamovic A."/>
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                <person name="Nusbaum C."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
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                <person name="Birren B."/>
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                <person name="David-Palma M."/>
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                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
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                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
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                <person name="Cuomo C.A."/>
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            <strain evidence="2">CBS 10737</strain>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
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                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
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    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF51257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC69035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012476.1">
        <property type="nucleotide sequence ID" value="XM_019155073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I6U2"/>
    <dbReference type="GeneID" id="30171693"/>
    <dbReference type="KEGG" id="kpin:30171693"/>
    <dbReference type="OrthoDB" id="2565175at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="582"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF51257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC69035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="634" mass="73309" checksum="ADF141B1C6197827" modified="2016-11-02" version="1">MEKLILRNPSNSEFESVDGIRNYLCRQRGSQPVPIAKWWNDRLHDSNPESSQKEWINETFLYLSAFAERCRIEEHTPRVGNMFDYDKETLELLRQRERFVARFGDLGERTMKRLDNKVIRNPYRDAFKSNQHLIDDSEVFVTYPRLSQVDSKATSEAVSYLVEFARRERDLRQGSQNRILNPWKNKGKGKGPSTQRNSTVSDHQGSSIPAMAAGNLDHDGQMLLERLAADVSLNPFSEHFDNPSTFCDYLRSPGPQISDLTEIVDQATTENIGQYITSLAADQRNVQDPQTIANLVEGEDTENMLSPVRSISVMDLINHIDTVSKQHGLDTPEYVQEETAVSQSSEFHADSTDREMENFARSFSSKNRGRAATGFLQELEEYTAKDSFDSAQFRVGQTADILSQNWPYFKTLKRKRAAFAENVERYAEWLAEKGTRASRRNTAYQNYTESLPSSSDNERWKRELIEWNQFQLDFRDRWKGFGEKGRQQLERLTIFIDSSGLKDKTSWLEYTTKEGIRSILTQPRWRAFLELEKTDTSRAERLLEFGVWYTNERISGKERENLILKQPVLEHEMREYKRLNGVKASENHTVDHSESSLGNLHEQSDDEGEDFGEAEMRSHRLMLFGLSAVPSTSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I737</accession>
    <name>A0A1B9I737_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peroxisomal ATPase PEX1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Peroxin-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I206_02069</name>
        <name evidence="15" type="ORF">I206_104537</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012574.1">
        <property type="nucleotide sequence ID" value="XM_019153834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I737"/>
    <dbReference type="STRING" id="1296096.A0A1B9I737"/>
    <dbReference type="GeneID" id="30170438"/>
    <dbReference type="KEGG" id="kpin:30170438"/>
    <dbReference type="OrthoDB" id="2187at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19526">
        <property type="entry name" value="RecA-like_PEX1_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000149">
        <property type="entry name" value="Nuclear valosin-containing protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.10:FF:000006">
        <property type="entry name" value="Peroxisome biogenesis factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015342">
        <property type="entry name" value="PEX1-N_C-lobe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF12">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09262">
        <property type="entry name" value="PEX-1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="393"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="677"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCF51355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WWC70586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1003" mass="110245" checksum="CAD37D18C84999F1" modified="2016-11-02" version="1">MARKAIVKYRSLRSNLVHLPLSIFAQLAQQQARPQSLIIHLSPLSASSSSLSARQPKAAYLGWSGLAASSSLTQAGEGIESIELDPEVAISLGWSEGTLVEISIIHNPTKAKSISVTPLTSDDWEILEQHASFLETHLLSQLRAAQKGQEIDVWVMGKTKIRIRVDETSPSTSTKEAALLNMDTEVYVAPRPREMSKPKEQIISNPSQQNGSGNVDGKRKGKYISLRLIPYRVASTWGTPDNASINKSKLALCSSNTIERIRRKLGLKVDKNDVIIQLDETDEDKVMPNDTSAVQVEAEKKSLEPEIKNTELQLVEWDEMPDGHVTIIGGAQAWENQWSIVKILPKLPRNGKSARRTSTTSAIPASPTLPLPGQQQLINNAITYLSRSLLSGSNRPILIEGNRGSGKTIVAKIIAEQVEKDRSILAEPVYEDVAKLDPESRLSIIKETISDWVSNAERRRPCCLILDGLDNLIGVETELNSSSNPAILADHFSRLFSSSSLPSGVLVIVTSTSSTTLHPSLSAKHVFGETLKIPPLTKELRQDILRILANEQASPPASKLINGVHEESAADAIDYLTLSGLTEGYSISDLADLLGNAAQQSIIRSIKYGEIFRLTMEDFVLAQEAFTPLSLRGVSLQKSEVKWSDIGGLHEPRRMLRETLEWPTKYAQIFANCPLRLRSGLLLYGYPGCGKTLLASAVAKECGLNFISVKGPEILNKYIGASEKAVRDLFERASGAKPCVLFFDEFDSVAPKRGHDSTGVTDRVVNQLLTEMDGAQGLTGVYVLAATSRPDLIDPALLRPGRLDKSILCDMPTHEDRKEILLSVAKKLHFSLDVNWDEIAKRTQGMSGADLQALTYNAHLEVVHSTLDKLSLEEENNGKAKSQKNGYLDIGSQKSNYKQIQPIEEEVSAAVRSELVNRMNVIGKNNTRQKGEERDLTNGKKENEKPIISYQYLLNSLESTRPSVSSADMKKLQDIYRLFASDRDGKMGDGDLGRSTGTRVSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I748</accession>
    <name>A0A1B9I748_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vps72/YL1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_02081</name>
        <name evidence="5" type="ORF">I206_104548</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
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                <person name="Imamovic A."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="Gargeya S."/>
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                <person name="Berlin A.M."/>
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                <person name="Griggs A."/>
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                <person name="Imamovic A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
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                <person name="Heitman J."/>
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                <person name="Litvintseva A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
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                <person name="Litvintseva A."/>
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                <person name="Mohammad A.W."/>
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        </source>
    </evidence>
    <sequence length="2008" mass="226277" checksum="CE77BE20A4DA2760" modified="2016-11-02" version="1">MPPRAGPSNGPARKKKAIPTFIPSTQFANTSSPRSPREESEDPLALSPIKVTPIVKNRTRRGTRSSNARQSSPVQLYSDLPSSTQRVTRGSKRRDREVEELDEDDEDLVPPSEDDEYEVWREARRIRLNQVEEKGTGRGFEAERRGMDVGKIEDKRMKRPKKPDKTIQERTFESLLPTPSPPSHSPSISSSMSDTRSRNTSPTQPLSYSQQDDPFYILHEGQQYTPYLAIEAGNQHDEMELLNKVQAQQKLPAEVGNTMSDSDKSRSPTPQTMLLLPLQDQAFETLAPAPSNVKIPPTSSQMNSGISPAQNTSQDIAELLSSPYRSPTPQTIPFLPLGDQGFETMLSEAGFSAVEDSEATRPTAMQFLMPPHMSLPPQQDEEFDTRSPIAMMDVEESVAKTLSPHAPFDGDITITLSPGRNEMLLSPPKHPEPIQQSSPARSLSQMFAAVAETNDSHAFAMPNLPTPPPIDPLLQQFRGARTFRTRTVLQLQPYTKEKQIYEAALRKGGLKKGKKAIAPSREITQEEDHDDEAQVSESSEASAAEESPERIVIGDTPPLKKTREPKKLVDTDFDEFFFEHGTAADEDNSDHVESLQKIARKRLKAAKEEKKRLKEAEKERERFESLMRDMRGEQDSSENEAHDKIQDDARPFIAKKRSAVRTPNGVKTYGNRTKLNRVAVLSPPDAADNALPSITHSMLSPSKSQGNTPTASFRTAFSGFNDIDMDVGYGQPQDESFLMEDESVQRQTPSLARENSFFINDLARSPSPSRLRSNSDSDSSTNSGIVQDRRKKIAGRMMPAAMLKRLEAEAAAKERQRQEKKSRRQAVTESPIRPGRAVKRRGGGHGGLEDIDALFEDDDPENVSSHTPSISYNRSPPNSFDQPIVVSDGDSSSEAEEDNQTEHTLARLHRGDFESIVSGVRWKQNTAKRKDRKFRVKSRSDHGRPALGLAKRVRAPISETNRAMLQSRLDFPVMDKSPITSTKKTRKRPFHQGRQQRPAIRLDDHVIFTAADFEFDDVEESPRPVLKQKTIPRQFARTTSANLNQTKSLDTDMGKARSWANFDKFSIDFDITPLPSGLYCNSASIPGTGQLARLVKDLQGLDCDTDLAACFDYGIELRQDMTPSAIQAVVPLLFDAAFRQMMTILNEDEAESLPLGCFIFLGRYITVHQRDLVETTLPMVSDVQTSIRQLNLKLEGIDIGRNKQGRNSLLEFRWAMLELSCRVQSKRKITEDSLVRLCAVKLFRQLLSYGFDRTIRPLKQIMRGESESAEISDITVTMWISMITTLNAWDNAKTESTENTFMICLNEAFDSIFEHDRSGPIAAERIWFLVFGLCALSQFNMNGKIDSLFITTPRWLLVRRAVGLIKVAFDEDAEKRAQLDQLRGRDRYIKVMMARCVRLSAIWKWSFDRESFSVATRDLGIIFKDRQYRNLPTEPPVDYPDFITRFDMSLTAAADTKRETAFELYLRLVCVAASDIISSAQTLTEAQQAEKDVQRLVMSIIPVSAVKFNRLFPPSPKDLGQLINRYSTMIAGCYFSPSLLSYLLANSKSWSSFESADFDSRQIAIRGLMYLCVATRHHNQPLKPIINRLNELMKILQGELEYLVGPSASVNQSLNNGPTKMEIERTMVLIVSCFKQMIKYHSFAVEEQEKAVYPDPSLLHESWTVRIFDLELSKDLKCGLQVIATIQSFLDTRASALPKLAKQRREAKESHNESFDEFGSLGIDFTDADVLALGGELGEEDQEVEQKDVEFAAIIENVISPKIYRLLSDMLPPVPDDEAGKRDKDMDRQPFISRLTKCWSDCAAVLVVEHQKLDWSTFISPFGRQSWARLGDEKGRVQVGLHFMLNVAQLDLGAFVYHEEDFVALFFQVIGTDRLTVEHHYTSALLAMRGSLEHPLLAPLRNIEAFERELSRDGFMGIRGEALRAIFETIPDLLRSSRTAASIKSFTYKCINLFVSSLISYEKQIDSNKIIHKESYRAFTDTIIRDLRRIAGDFITPLSVPGLKHFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I8R6</accession>
    <name>A0A1B9I8R6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Allantoate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_02663</name>
        <name evidence="9" type="ORF">I206_105122</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC71169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013166.1">
        <property type="nucleotide sequence ID" value="XM_019154426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I8R6"/>
    <dbReference type="GeneID" id="30171032"/>
    <dbReference type="KEGG" id="kpin:30171032"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF59">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF51947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC71169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="545" mass="61242" checksum="94315241CDB8A82A" modified="2016-11-02" version="1">MFEEKKDLEEHIEGISNEPVLEDKKRHKANNQLDEAAAYLAQAGHVEYTAEERRAVIRKIDLFVCVPMCMTYFLQQLDKSSLSYAAIFEIQKETGLVGSQYSWLSSIVYIAQLCLQPASSYALIAFPIKYWVTFNMLAWSIVTVCTGAAKNFTGLIICRLLLGIFEATILPSFIFLTQMWYTRREQSFRTIAYQIANSFAAILGPIMSFGIGKATENSSTVKEYQGIFFFIGSVSVAFVPVIFFMLPNSPTTARFLRKGNDRVIAIDRLKENQTGTKSSQWKWNQVWETYKDPKTYIWAVMYFCTSTPSGGFGAFGGLVVKGLGFTSFKAILMQAPTGAIAILTLLITIFLTNRFRARWAIVAACVVPPIAGAVGLVKVQRSDPYILLACYYVAQSLAGIQPLLYSWANLNQAGSTKRVVVFATMFVAQCTGNVVGPQVYLTRESPYYHTGLYVNIGCWTVLFCLIVFMRFYLTYLNKKQVQRRVALGLPADLKDMSIMPYGELEAYKAELAQQMTAAGLDSAKLYENAFDDMTDFENPYFIYVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I8S2</accession>
    <name>A0A1B9I8S2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_02632</name>
        <name evidence="2" type="ORF">I206_105092</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC71139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013135.1">
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                <person name="Heitman J."/>
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                <person name="Heitman J."/>
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                <person name="Litvintseva A."/>
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    <sequence length="733" mass="80874" checksum="A3FCE109FC9EA0A0" modified="2016-11-02" version="1">MSNQHHDPSADLAARMNGLGVNGESGYSSPQQQPNSHHQSPVNMTHNYANIQSPPSRAAPGLQSQPYSPFPDQTGYPYYPGNAPGGPLGVGLTSATYATSPANIGPNHATYAYVPQTSDLINLNNSQQTSASYDGSFPTPNELYGGQGDQSQAHHRTNQDASSILQQVPRLTRQPYRPPTGQSAYQQAAMQQANASANGYYNFQDPRYQWVGQSQNMYTHQGNMRKKDGQNNTYNSRNNNSYSFRSNQNVNNSHFGYNDSVTPTRGAFAGTSSGLNPYNASSNLYHLAQAQGYGNAFGYSPGYQNASGFVLRPKRSEDPNVVRSALLEEFRLNKVGKWELRDIFGYLAEFSGDQHGSRFIQQKLEIATPEDRQKLFDEIMPNSYQLMTDVFGNYVTQKMFEYGDQKQKATLAKKMEGHVLALSLQMYGCRVVQKALEHVLVDQRSLLVSELEGHILECVRSSNANHVIQRLIQLGPPQSVPDSFIGHIEELAKHPYGCRVVQKMFENLDESMVRSLLDEMHNFTADLMEDQFGNYVVQSVIIVGKPEDRDKVIKEIKGRVIPFARHKFASNVVEKAILNADESDRKLLIDELVGLKEDGTNQVGMLLRDAFGNFPLQTALKAASPEHRQELLDIIEPLLPQVRNTPVGKKLEVQIEELKKGNDQSANGSSVGDSTTDTNGTDTTPGGLTMSRSTSEETSLSSPPENIVDIRAKSTTPRVGNGNGAKTLEDLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IAQ7</accession>
    <name>A0A1B9IAQ7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_01784</name>
        <name evidence="3" type="ORF">I206_103211</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013713.1">
        <property type="nucleotide sequence ID" value="XM_019153552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IAQ7"/>
    <dbReference type="STRING" id="1296096.A0A1B9IAQ7"/>
    <dbReference type="GeneID" id="30170153"/>
    <dbReference type="KEGG" id="kpin:30170153"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="1">
        <location>
            <begin position="7"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF52494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC69273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="377" mass="41693" checksum="E180AEC9FA476D94" modified="2016-11-02" version="1">MTIQNSKLFAPIKVGTVDLKHRIVMAPLTRFRAEKGTGVPGEYAEEYYSQRATDGGLLITEATFISEDARGYDNVPGIYSKEQIAGWKKITDGVHAKGGKIFVQLWHLGRVAKISPVIYAASDIPDPTDEGPKPTLHVLTESDIDKTVGDYVHAAKSAIEAGFDGVEIHGANGYLIDQFLQSVSNQRTDQYGGSLENRFRFPLRVLNEISKAIGPGKVGIRMSPFGKFQGMREEVPLDTFIPWTKAIVENQPNLAYIHAVESRVAGSTDTPIEQRVGADNLDEIRRITTEAGVKFMVAGGFGSEGGFPKEHADKSDDLIAFGRHFISNPDLVNRVKNDYPLRKYNRDTFYSPGPKGYIDQKEYNAISQDHAEEVETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IAU8</accession>
    <name>A0A1B9IAU8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pre-mRNA-splicing factor CWC21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_01982</name>
        <name evidence="10" type="ORF">I206_103012</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC21 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013908.1">
        <property type="nucleotide sequence ID" value="XM_019153747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IAU8"/>
    <dbReference type="STRING" id="1296096.A0A1B9IAU8"/>
    <dbReference type="GeneID" id="30170351"/>
    <dbReference type="KEGG" id="kpin:30170351"/>
    <dbReference type="OrthoDB" id="10267305at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21372">
        <property type="entry name" value="cwf21_CWC21-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051372">
        <property type="entry name" value="CWC21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013170">
        <property type="entry name" value="mRNA_splic_Cwf21_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562">
        <property type="entry name" value="SERINE/ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562:SF5">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08312">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01115">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="CWF21" evidence="8">
        <location>
            <begin position="63"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="24"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="143"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="143"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="317"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="337"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCF52689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC69076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="402" mass="45276" checksum="B0A9C7C4A77F07AC" modified="2016-11-02" version="1">MYGNVGLLTARGSGTNGYVSRNTAHLKVRDGPPGGSYGSGSRYGDYDDAKGPPVHRAPDQGILEHERKRRIEVKVMELRDELEEKGIDETDIDDQCDALRAKLSSANLPAPRSRPTDSHSIAAAKEAEMSRMGRALGVSASHVEGKAFQRETEEERAARLAEREERDKARVEAALQREREAERGKKEWEEKERLRRREEYKKQQEGSKSSRRDDVPPRRSISPPAVRRSRDDSPPRRRPRSPSESLSPPPTRRRRSPSASHSPPPVKRGRLPTDSRSPSPRRRRPPSDSRSPPPARRRRSPSESRSPSPPPRRTARRYSSSPPRGRASPSPRRKLRDRSSSRGRARSDSRSVSPPPRRTRYSSDSRSPPPKRARADSSEEGTPRSVRSLTPEPTKKRVEKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IB07</accession>
    <name>A0A1B9IB07_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxin-7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_00114</name>
        <name evidence="11" type="ORF">I206_101209</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the WD repeat peroxin-7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF52818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014037.1">
        <property type="nucleotide sequence ID" value="XM_019151899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IB07"/>
    <dbReference type="STRING" id="1296096.A0A1B9IB07"/>
    <dbReference type="GeneID" id="30168483"/>
    <dbReference type="KEGG" id="kpin:30168483"/>
    <dbReference type="OrthoDB" id="273771at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005053">
        <property type="term" value="F:peroxisome matrix targeting signal-2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044536">
        <property type="entry name" value="PEX7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027:SF1">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="108"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="151"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF52818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC67301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="335" mass="38128" checksum="8D818555890B1465" modified="2016-11-02" version="1">MTMGQPFLRLKTPKFSHNNLSFSPYFENRFALASGSNFGLVGNGRLHIIDLDQNVFGGLKCIKYFETRDVVFDVAWNETHENQIFAACGDGSIKMFDVTLEGLPIKSWHEHSSEIMSIECSNLQKDKFVTASWDSTVKVWTASRQTSLITIQAHKGQIYQATFSPHNPFLLTSCGSDGNLNLFDLRQQNSNHDLNNSIKPIISINSNLNSNLNLNQEIEILHCDWNKYDENLIAIASKDNLIKTFDFRLGSNQFGKIIGKNQLSCRKIQWNPYNRNQLASVGYDMTCKVWDTNSTLPIFIHSEHTEFTMGICWSLFDPGLLASAAWDQEVHLYRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IB43</accession>
    <name>A0A1B9IB43_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="4 14">1.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I206_00165</name>
        <name evidence="17" type="ORF">I206_101161</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32271"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 14">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="WWC67254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019151946.1"/>
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    <dbReference type="STRING" id="1296096.A0A1B9IB43"/>
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    <dbReference type="KEGG" id="kpin:30168534"/>
    <dbReference type="OrthoDB" id="419183at2759"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
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    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
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    </dbReference>
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        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
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        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004429">
        <property type="entry name" value="Isopropylmalate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00169">
        <property type="entry name" value="leuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
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    </dbReference>
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        <property type="entry name" value="Iso_dh"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="12 14" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5 14" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0520">NAD</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="7"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCF52865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="WWC67254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="373" mass="39702" checksum="9E21BEF123D70B3D" modified="2016-11-02" version="1">MSDKTFKIAVLPGDGIGPEVVDQALKVLSTISEYSNLSLDLQKYDFGGIAIDNHGVPLPDVTLNACKAADAVLMGSVGGPKWGVGPVRPEQGILKLRKELGLYANIRPASFASENLLKRSPLKEEVAKGTDIIVLRELIGGIYFGDRQETDANGVAWDQCTYSIPEVERITRVAAKIALAADPPLPITSVDKANVLATSRLWRKTVTELMAKEYPQLKLEHQLVDSAAMIMVANPRKLNGVLLTENLFGDILSDESSVIPGSLGLLPSASLAGAPDANSTTMGLYEPIHGSAPDIAGQGIANPIGTILSAAMMLRYSLGKGKEASLIEKAVQKVLDSTDVGGYDFRTKDLGGDAKTEQVGDKVVEALKELLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IBE1</accession>
    <name>A0A1B9IBE1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_00060</name>
        <name evidence="4" type="ORF">I206_101262</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF52764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013983.1">
        <property type="nucleotide sequence ID" value="XM_019151845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IBE1"/>
    <dbReference type="STRING" id="1296096.A0A1B9IBE1"/>
    <dbReference type="GeneID" id="30168429"/>
    <dbReference type="KEGG" id="kpin:30168429"/>
    <dbReference type="OrthoDB" id="2603at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF52764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC67354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="43310" checksum="F5F96691D974496E" modified="2016-11-02" version="1">MTTVKRNETLILKKHRTPHSFFTPTHLSFIDPHTGNSNASWNSRRARKGRYSTKVHNIHYTKSSLNDLENEEPSIQSNTFSRIKKEESKLQFNLKLDITFWLAIAFTLGSMVWVVNGFLVFLPILRPSLDIPSYTKTASATAFLGGSIFEIGAYLGILEVLNRGKEIHFNSSFGKLLHHRRKQQPESTIKSDIVKSKHKHGNTSFNTSTETSQDDLPISNKNKFIWWGKPMWHDMGYLAALIQFFAATIFWISTLTGLPGVIPGFSEGEGSIAIIDIFFWTPQVIGGTGFIISSLILMIEVQKKWYLPNLTEIGWWVGVWNLIGAIGFTLCGALGYSLNSKAIYQSGLSTYWGSWAFLIGSICQVYEAIWREPESDNSNKEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IBZ2</accession>
    <name>A0A1B9IBZ2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histone deacetylase 1/2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_00264</name>
        <name evidence="4" type="ORF">I206_101062</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF52963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014182.1">
        <property type="nucleotide sequence ID" value="XM_019152044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IBZ2"/>
    <dbReference type="STRING" id="1296096.A0A1B9IBZ2"/>
    <dbReference type="GeneID" id="30168633"/>
    <dbReference type="KEGG" id="kpin:30168633"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF2">
        <property type="entry name" value="HISTONE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
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        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="2">
        <location>
            <begin position="104"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF52963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC67155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="612" mass="67684" checksum="5119545A681A4D49" modified="2016-11-02" version="1">MSTLSDPVTAGEGSSKPSKRVAYYYDQDVGNYTYYLGHPMKPHRIRMAHNLIVNYGLTDEIENDAPNLNGEGKRELNDEFLSLSTTIIPENKFIKNSLSGSRSKTMQVFRPHRATKAEMTRFHTDEYIEFLENVTPELAEEMTGGGVRCLIGEDCPAFDGLFEFCSISAGGSLGAAERLNSGAADIAINWAGGLHHAKKTEASGFCYVNDIVLGILELLRIHPRVLYIDVDVHHGDGVEEAFYTTDRVMTCSFHRFGEFFPGTGDVRDIGMKRGKNYAVNVPLRDGITDESYHMIFKPVIQHIMDWYRPGAVVLQMGADSLSGDKLGGFNLTLNGHGECTSFVKSFGVPVMMLGGGGYTTKNVARAWTNETAVMCGRTLPEDLPYNQYMEYYGPRYKLEVLANNTDDHNPTDYLEKIRTQVIDNLRNLPHAPSAQIQHVPGQSISRLIGLTKESDLKDPDDEIDDRVKKYVMQKNLNGGYSPNSSDDEDTPMNGDSDEDDAAYALPGRSRRQGGIRSRRRLPTRIVNGKRNNGHEESDDEDDDPCGANKKKKRNFFNKSTTNGVQSIVNKKINGIATPYGNGTAITIGNGGVVEFWKDAGGISRGESPISTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IC72</accession>
    <name>A0A1B9IC72_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_00559</name>
        <name evidence="11" type="ORF">I206_100769</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC66862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014477.1">
        <property type="nucleotide sequence ID" value="XM_019152339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IC72"/>
    <dbReference type="STRING" id="1296096.A0A1B9IC72"/>
    <dbReference type="GeneID" id="30168928"/>
    <dbReference type="KEGG" id="kpin:30168928"/>
    <dbReference type="OrthoDB" id="9988775at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000001">
        <property type="entry name" value="Acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000010">
        <property type="entry name" value="Medium-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000011">
        <property type="entry name" value="Medium-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF12">
        <property type="entry name" value="ISOVALERYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016578">
        <property type="entry name" value="HsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="9">
        <location>
            <begin position="41"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="8">
        <location>
            <begin position="155"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="7">
        <location>
            <begin position="269"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF53258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC66862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="403" mass="43433" checksum="AAA42FDC40CFE4DB" modified="2016-11-02" version="1">MSLRTACPLRRLSSRSIRLDRRCMASAARPSTGPVSFTLDDDQRGIQELAQSFTRDKIVPAAAEYDRSMAYPWPILKEAHSLGLLNTHIPEAYGGPELGLLECALVSESLAYGCTGIQTAMEANGLAEAPLIVAASHETKTKYLGRMTEEPLMAAYCVTEPGAGSDVAGIKTKAEKKGDKWVLNGSKMCIIVLQRITNAGHANWFFVLAVTDPSASPSKGMTGFVVDADTDGIVLGKKEINMGQRCSDTRMVTFQDVVVPEENVLGKPGEGFKIAMKAFDITRPLVAAAAVGLAQRALEEATKYAQERKTMGQPIINHQGVAFMLADMAIGAEAARGLVWRAAWAKDCGERNTFYASMAKAFASKTAVENANLGVQVYGGAGFNTEMPMEKLYRDAKIYELCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9ICD3</accession>
    <name>A0A1B9ICD3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA (guanine(10)-N(2))-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.214</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I206_00609</name>
        <name evidence="15" type="ORF">I206_100718</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM11 methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.214" evidence="9"/>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014527.1">
        <property type="nucleotide sequence ID" value="XM_019152389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9ICD3"/>
    <dbReference type="STRING" id="1296096.A0A1B9ICD3"/>
    <dbReference type="GeneID" id="30168978"/>
    <dbReference type="KEGG" id="kpin:30168978"/>
    <dbReference type="OrthoDB" id="296065at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160102">
        <property type="term" value="F:tRNA (guanine(10)-N2)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RlmKL-like_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016691">
        <property type="entry name" value="TRMT11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059073">
        <property type="entry name" value="TRMT11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370">
        <property type="entry name" value="RNA METHYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370:SF3">
        <property type="entry name" value="TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25904">
        <property type="entry name" value="Tmrp11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017259">
        <property type="entry name" value="tRNA_mtfrase_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00507">
        <property type="entry name" value="N12N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51627">
        <property type="entry name" value="SAM_MT_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 10" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA (guanine(10)-N(2))-methyltransferase TRMT11 N-terminal" evidence="13">
        <location>
            <begin position="4"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA large subunit methyltransferase K/L-like methyltransferase" evidence="12">
        <location>
            <begin position="189"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="418"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="427"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00066937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF25904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCF53308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WWC66811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="487" mass="55178" checksum="27F154AA0B9AA49E" modified="2016-11-02" version="1">MTLYILRVSQDHLTFRIPSLLSISQLFNFPIRFISTDLYRGVLIVELQKEEDVQHILERDTLVSSISELYAEGKTYADLHEQMRGNLQVLKPYMRSSFKFTMEGVNHRVVETRIRETVESFAYTALKGDIKMKNYDEEFVIFEDYDFEAAHTSEARIGRDGNFVRVYFGRRIGFGKARLLANSHEVKARAYYGNTSMDSHMGFLMAGQALPAPGKIMYDPFVGTGSMLYAAAHWGSYVIGSDIDGRQIRGRDKTKGIKPGILRAAEQYGIENLFLDCLTYDITKSPIRRGGWVDAIITDPPYGVRAGAKRLGRKEGGKPLRDEPYLMPDGTYSHTRPGYVPPSRPYELANLTLDLVQLARWLLVPGGRLVFFLPTVTEDYTEVDVPVVEGMKELKVGDGSVQDFGKWGRRLITMEKIAQDDGPPPTFEDHEQFDPKNRPDYLPGHHAFRERYAAGFRPRQKNDDSSPISTSPPTLEPVVNIEKGQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9ICL3</accession>
    <name>A0A1B9ICL3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Hexose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_00524</name>
        <name evidence="12" type="ORF">I206_100803</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014442.1">
        <property type="nucleotide sequence ID" value="XM_019152304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9ICL3"/>
    <dbReference type="STRING" id="1296096.A0A1B9ICL3"/>
    <dbReference type="GeneID" id="30168893"/>
    <dbReference type="KEGG" id="kpin:30168893"/>
    <dbReference type="OrthoDB" id="2559802at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000117">
        <property type="entry name" value="MFS hexose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="379"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="30"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCF53223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC66896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="520" mass="57645" checksum="47F4955A14832B16" modified="2016-11-02" version="1">MAGDFAFNSVPNATAASWWNDPGLRKLVFFMAVCTSSAIGSGVDGSLINGLQIIPQFNENLGDISDNHLGLVIASFSLGALPALPISAYLMDKFGRKSSLLLGCLSVIIGGISQSFTFGPNSFLGTRFIIGFGIALTGTSAPTLLMELSHPRLRGQASLLYNCSWYIGAVIIGWCTYGTLNWTSNWSWRMPCLFQIFPEVLLGIVTLFFMPESPRWLVSKGRNEEALRILAKYHANGEENDPLVRLEYSEICEALESEKTSQHGTSYLTFLKTKGNRHRLVICVLVGFMCQWSGNGIVTYYLSPILTAAGVTSSSTQALINVCINIWNYPWAIAGALSANKLGRRTLFFISTGGMLICYIIITALAAEFNKTSKSSIGYAQVAFLFFFFASYDFGFTGLQSAYPIEVLPYSLRAKGYSITQFCIYVALFFNQYVNPIGLSHIGWKYYIVYDVILVVFLILQYFLFPETKGRTLEEIKEIFDNTSLEASDAINQSRAVGEDEQGEKKYEEHTFVENIPGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9ICM4</accession>
    <name>A0A1B9ICM4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_00518</name>
        <name evidence="10" type="ORF">I206_100809</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014436.1">
        <property type="nucleotide sequence ID" value="XM_019152298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9ICM4"/>
    <dbReference type="STRING" id="1296096.A0A1B9ICM4"/>
    <dbReference type="GeneID" id="30168887"/>
    <dbReference type="KEGG" id="kpin:30168887"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF683">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="429"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="60"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCF53217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC66902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="479" mass="51463" checksum="222352B28B90B0E4" modified="2016-11-02" version="1">MSNNSNLSEIEMGRQTSRNCNPENENESEDPKNKTKQNTVIDAVWGEIDLNDGSSPNYRNLGWIKASVLEVKTQIGLGVLGLPAALNVLGFVPGILCILAIAIIITWSDYVVGTFKMNHPEVYTVSDVGYIMFGPWGREILGFAYLLEVVATGGASFLSISVAFNAITDHATCSVVWAIIGAVVVGLLSSIQTLGKISWLGWVGLVSILSAVITLMIGLGTSGKPSLAPAGNDWQIETKAITSPSFVEAINAVCIIIFAYAGTPNFFNIVGEMKNPKDFTKSVLVGQTAITTIYLVVAAVVYHYAGQYIASPALGSAGVVLKKVCYGLALPGLAVGGTLFMHVAAKYIFVRVLRNSRHLAKNTPTHYIAWYGSVVLVCTVGFIIAEAIPFFNDLLSLIGALLATVICIQMESFMWMWDNIRSPSRGTTSWNLLMAMNILFFILGWFLMIAGTYGSVVTINDNFKSGDVGSAFSCADNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9ICU4</accession>
    <name>A0A1B9ICU4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_00658</name>
        <name evidence="2" type="ORF">I206_100667</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014575.1">
        <property type="nucleotide sequence ID" value="XM_019152437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9ICU4"/>
    <dbReference type="GeneID" id="30169027"/>
    <dbReference type="KEGG" id="kpin:30169027"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCF53356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC66762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="204" mass="22985" checksum="9E743BA444B39329" modified="2016-11-02" version="1">MHDWKGANDLGTSFAFRRPRPFPSFGRGTCSTPDTCNPHFGTIDSSGICLDRPCNTVSIDQEAESEIPLDTVHVQRVLDKIPEANAHKLFVQRAVFLPTSTRSSSKQHEDQYGFYFVADEDATDPVYHTDMSGESITKSSGITQSDRFEEIVTLVSESIVSWTEQATKSTCESFYAKDKHLEVMGEWCEDKKRWDVLALDHLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9ID28</accession>
    <name>A0A1B9ID28_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">pyridoxal 5'-phosphate synthase (glutamine hydrolyzing)</fullName>
            <ecNumber evidence="3">4.3.3.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I206_00615</name>
        <name evidence="14" type="ORF">I206_100712</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + phosphate + 3 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the PdxS/SNZ family.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="3"/>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014533.1">
        <property type="nucleotide sequence ID" value="XM_019152395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9ID28"/>
    <dbReference type="STRING" id="1296096.A0A1B9ID28"/>
    <dbReference type="GeneID" id="30168984"/>
    <dbReference type="KEGG" id="kpin:30168984"/>
    <dbReference type="OrthoDB" id="1660966at2759"/>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04727">
        <property type="entry name" value="pdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000001">
        <property type="entry name" value="Pyridoxine biosynthesis protein PDX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01824">
        <property type="entry name" value="PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001852">
        <property type="entry name" value="PdxS/SNZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033755">
        <property type="entry name" value="PdxS/SNZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003215">
        <property type="entry name" value="PRK04180.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00343">
        <property type="entry name" value="pyridoxal 5'-phosphate synthase lyase subunit PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01680">
        <property type="entry name" value="SOR_SNZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029271">
        <property type="entry name" value="Pdx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51129">
        <property type="entry name" value="PDXS_SNZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0704">Schiff base</keyword>
    <feature type="domain" description="PdxS/SNZ N-terminal" evidence="12">
        <location>
            <begin position="47"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with D-ribose 5-phosphate" evidence="8">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="274"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR029271-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR029271-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCF53314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WWC66805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="335" mass="34642" checksum="2B6838CDBCEC71E3" modified="2016-11-02" version="1">MSSEPTIVPSSAVNLNGGTPSQGGTSTPLLGSRGGPTGSVGAGGSFGVKSGLAQMLKGGVIMDVMNVEQAKIAEEAGACAVMALERIPANIRRDGGVARMSDPGMIKEIIEAVSIPVMAKVRIGHFVEAQILQAVGVDYIDESEVLTMADDQHHIGKHAFKVPFVCGCKNLGEALRRISEGAAMIRTKGEAGTGDVVEAVKHQRAVMADIRKAAAMSDEELYAFAKDLSAPYHLLKETARLKRLPVVSFAAGGVATPADAAMMMQLGCDGVFVGSGIFLSGDPAKRARAIVQAVTHYNNPTVLAEVSTDLGDAMVGISVAGEKEIKGGRMAGKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IE14</accession>
    <name>A0A1B9IE14_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dynamin GTPase</fullName>
            <ecNumber evidence="3">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">I206_00977</name>
        <name evidence="21" type="ORF">I206_100348</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="21" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="3"/>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014890.1">
        <property type="nucleotide sequence ID" value="XM_019152752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IE14"/>
    <dbReference type="STRING" id="1296096.A0A1B9IE14"/>
    <dbReference type="GeneID" id="30169346"/>
    <dbReference type="KEGG" id="kpin:30169346"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000741">
        <property type="entry name" value="Putative mitochondrial dynamin GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056495">
        <property type="entry name" value="LIS_MGM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF212">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24550">
        <property type="entry name" value="LIS_MGM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="19">
        <location>
            <begin position="246"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="18">
        <location>
            <begin position="844"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="152"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OCF53671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="WWC66446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="956" mass="106126" checksum="E975FFCD29DA3C1C" modified="2016-11-02" version="1">MLRKLPLSSRPYILNQIRPRPNLLPRTPIITTTRNVHVRAISFSSIPRAMARAFRIPAYGAAIGAGGLGYANYKLEGVRNATSEILSNVSDKFSSAYNSAADGFNTAADLGASLGSQLQGKLSDTSHGVQDTAEAFKNGTKEWWDAFSAQFAKSPQSENTSSSNSSSKGREERWDPGEGPGEPKSPNNGEEALLGLIGAAAVSSQKEEKVSDPFSSGGGDDHHLLQLTRKLIEIRSVLLSVDQSEALQLPSIVVIGSQSSGKSSVLEAIVGHEFLPKGDNMVTRRPIELTLINTPPNAASSSSTPAEYGVFPNMPGMGKITSFATIQKTLTDLNLSVPPELAVSDDPIHLQIHSPHVPDLTLIDLPGYIQISSMDQPEELKDKISGLCDKYIREPNIILAVCAADVDLANSPALRASRRVDPLGTRTIGVVTKMDLVKPEHGATIVRGERYPLHLGYVGVVCKAPPTTGVFRSIRGDKETPNVTGAVLRREEEFFGGENAKYFGRDKKAMVGTDTLRRRLMDVLETSMSSSLHGITNAVQLELEEASYQFKVQYNDRRITSESYMAETIDALKARFKEYTAQFTKPAVRSKLKDMLDEKVMNIMERLYWDDPRTLELAKLAEDKKLTSEELDTYWKYKLETASSLLTKSGVGRDSTGLVAEGLRQLIDSIATGEPFTFHPSVSERITEFSHAILRERMGLTADQVENCIKPYKYEVEVDDREWNIGRERSELKFTQEIKRCDDKLNDIKNKLGGSRKLNSLIRHVGELEKWEDDRKKRRFSAGAVGGTEVEDGVLEEGAPVLDAYKYSPAQIIDGRHALLLSNRLNLLKIRQQALKSRRCKLGPDQSAFCPEAFLAVVADKLAYTSTMFINIELLEQFFYQLPREIDSRILYDLDRDEIAKFARENPKIKQHLDLQERKDKLESVMRSLQSLVNLQKDAKGTSTTSRSQGLFTKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IE38</accession>
    <name>A0A1B9IE38_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_01074</name>
        <name evidence="4" type="ORF">I206_100251</name>
    </gene>
    <organism evidence="3">
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        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
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            <strain evidence="3">CBS 10737</strain>
        </source>
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    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
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    </evidence>
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        <source>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Dewar J."/>
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                <person name="David-Palma M."/>
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                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
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                <person name="Springer D."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
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                <person name="Dewar J."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="552"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="586"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="614"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="644"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="672"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="269"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="420"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="697"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="304"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="430"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="709"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC66602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="737" mass="80788" checksum="D8F85D66BB02D134" modified="2024-07-24" version="1">MQQTIPSTTPIGSPHFARNDPWAHALICCDHDHDASSSKHNAFNQVAFHQQLQSNLSTGSTPIQQEVYGQIPPNTYPSAQSIDQPQTGRCAELRADCALEAYCCGGDYCCDEAHGCDKSNNTDYCANPACEETMKEPCHEEHPFHPQGLCGDVDYSHDQDMKSLEAWADTKEGCHAIQQLLECCNQPDCDIPVCPTENESIHPPAPDPLAAIFGSMVAQPIEPSLTAGGLSSDVEAMSHTCHWGNCHLVFKSMPDLLAHVAADHLSAWSSGSGPKSTDAAQNQQSTLSVPPPQQMPNAMAPANFASTPPLQMTNNVTSGITINSTFPTPQESETDRLLSCLWDDCFPMTDMPGSIGDTFSQHNPSQSLTQQIPHMHSHTHNQPHDHTNASGEPFSPGTMLRHVLEEHLGVPGSIIGWPTEPQQGQQVDKNHHHHHVDPHHLAHHHDHSHAHPYSHHHHGHSHLHSTNLDHPFPTPPSTVETRLSTSPTPNFGSSHDLSGNISKASKTNAIKANGNGLICLWPGCPIDHVFQDSASLMDHLSEVHIPKGKDSYTCHWDNCGEGQGRTFKSRQKVLRHLQSHTGHKPFVCGVCDQAFSEAAPLSAHMRRHAQQKPFKCEYPGCGKTFAVSSSLTIHMRTHNGEKPYICPHCDRGFVEASNLTKHIRTHTGERPFSCSHPGCGKKFSRPDQLKRHMLVHNKPQGQHARRRNSVQTAKSEQKAAPSSVNVGHNQNTIQATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L0A7</accession>
    <name>A0AAJ8L0A7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_101696</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alkB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008654.2">
        <property type="nucleotide sequence ID" value="XM_019158041.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L0A7"/>
    <dbReference type="GeneID" id="30174705"/>
    <dbReference type="KEGG" id="kpin:30174705"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032862">
        <property type="entry name" value="ALKBH6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46030">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46030:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="8">
        <location>
            <begin position="131"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC67784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="314" mass="35052" checksum="275C86AF83F58A8A" modified="2024-07-24" version="1">MPIPIFDDQISSDVENENDNDKGTPLVREFPPIEHFRIQNVPPAAYYIPDFITKEEEEYLLRKVEESPQPKWRKVGTGRRLQYWGGTMSKKGILLPEIIPDFLTSFPDIIERIESLLRDGSIKGKEKMGLDINQVLVNEYLPGQGISPHEDGPAFRPLVATLSLGYHTILDIHHYLNPTKPSPPMTSQVESDTESGKTIAAIPLAHLLLMPRSLLILKSSLYTSHLHSISSKEEDTIVHRTLSDSVSEDRIVKANGGVEIANMELLGDAEVIDSLKNTGEWTAKRDTRISLTFRQAEKVLKGGALGALSNALKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L0U5</accession>
    <name>A0AAJ8L0U5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Nucleolar essential protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_102020</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC68099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008331.2">
        <property type="nucleotide sequence ID" value="XM_019158585.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L0U5"/>
    <dbReference type="GeneID" id="30175257"/>
    <dbReference type="KEGG" id="kpin:30175257"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070037">
        <property type="term" value="F:rRNA (pseudouridine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18088">
        <property type="entry name" value="Nep1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.10:FF:000003">
        <property type="entry name" value="Ribosomal RNA small subunit methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005304">
        <property type="entry name" value="Rbsml_bgen_MeTrfase_EMG1/NEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636">
        <property type="entry name" value="NEP1/MRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636:SF5">
        <property type="entry name" value="RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE NEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03587">
        <property type="entry name" value="EMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="65"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC68099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="37673" checksum="3233E1DA8E960452" modified="2024-07-24" version="1">MSNRSGTPPKRRISEANNSSQPAKSSKMSASAPLFIPSNSKPNTITNTNTIKSFHDISKTLNNNNNNENLGDGAEDVAGNIPIGETSDRITKPLPSSSSSSSKNQQQRADFVPKPAVVPKTHADKENTRRLIVVLSQACLEAYRVSSGSGGKNTSGKEAKYALLNCDDHQGILAKTGRDIADARPDITHQCLLTLLDSPLNKAGLLQVYIHTARGVLIEVNPSVRIPRTFKRFSGLMVQLLHKLSIRGVNGSEKLLRVIKNPITDHLPTNTIKLTLSADAPTIRLSQFLPTLPETHSVCVFVGAMARGADNFADQFVDQKISISDYSLSASVACGKFCCAMEEIWNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L2H0</accession>
    <name>A0AAJ8L2H0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_101879</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058570.1">
        <property type="nucleotide sequence ID" value="XM_070202469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L2H0"/>
    <dbReference type="GeneID" id="30175399"/>
    <dbReference type="KEGG" id="kpin:30175399"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="308"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="392"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="83"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="525"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="123"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="525"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC67960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="655" mass="72190" checksum="C4AB2FD4DB62FBD8" modified="2024-07-24" version="1">MSTKSVSRSLSPSSPPFIFPQSPPSRADSTSTETLASTYVNTGSSSSESERQLVTSKAVGAEREKAKTLASSIPTATAKSFGAGWKSSSSLKSHDSPLSQGGGIQAFLPIPANGGTFGTTIGSRSRSPSLPILPSSTSVYRGNPSLAAQGPTLAPINTQSLPHDFELHTPCSPSSGGGYFASHPISPNEDTPHTHPLRHHPSMSSIEIELDDHSLPYSQTDIYGSISPINHHTSVPNLPFVQNAMYRKPSGLRFEYEDDDTPIQYDSELGMKRGLRRMPAFNFGQMGARSKLMSTKSMPVIPMMGEGRNVFIHRVNEDLSEDGLKAYASDFGDVISVKIPPRTTRPHAFVMFKRPEQAQNFIAHLKMRNIECEFGKEDYQVQNKALEDPNSANMYISGLPTTLTFDELSDLLAPNKICSWKPLVDEAGNRRGPIMARLQTRVQANDVIHKINGKYYQGMSERIQARIADSDEQKQFKRHQSFSRDRPIPVEPIIRSEFPDEDANDIELLQTREFLASQLEAINNKLSRTQTRPTKDSSLPNRNGYETDIIGPSPVSVGQVPSWATGHRHTSSNYSIDPFGSWPDWTGTWGHQAQSATVYDNHVQPRQQSLSLSDQGHPNFKAGTFPPNTLHLVKSSPELGGNYDSTTKLWWKDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L2T5</accession>
    <name>A0AAJ8L2T5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">valine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Valyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">I206_103491</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Val) + L-valine + ATP = L-valyl-tRNA(Val) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="3"/>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058877.1">
        <property type="nucleotide sequence ID" value="XM_070202776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L2T5"/>
    <dbReference type="GeneID" id="30169874"/>
    <dbReference type="KEGG" id="kpin:30169874"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00817">
        <property type="entry name" value="ValRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000010">
        <property type="entry name" value="Valine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000009">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000020">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000078">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000008">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02004">
        <property type="entry name" value="Val_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004349">
        <property type="entry name" value="PRK05729.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946:SF109">
        <property type="entry name" value="VALINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="VALYL-TRNA SYNTHETASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13 18" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="16">
        <location>
            <begin position="119"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="17">
        <location>
            <begin position="798"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1022"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="WWC69549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1085" mass="122558" checksum="52861399AC6428FA" modified="2024-07-24" version="1">MSSEERKVAPSAELLPVEQANPAEGGAAALAPEAPAEGVKEITKSAAKKEAKRLEKLAQKAAKGPTVAQGPKKDKAEKKEKKAEAPVEEWVNTTPKGEKKDVSGNLPAGYDPIQVEAAHYDWWKSRGFFKPRYDADGKPLEKGTFCITLPPPNVTGNLHIGHALTISIQDALIRWKRMQGHTVLYLPGYDHAGIATQAVVEQRLVKTEGHSRHYYGREKFLEKVWEWKDQYQAKITNQMERLGGSYDWDKVAFTMNESLSKAVQETFCIMHEKGLLYRANRLVNWCVYLNTSLSNLEVDQMALTGRTLLNVKGYEAKEKFEFGVITSFAYPIENSDERIIVATTRPETMLGDTAVAVHPDDPRYKHLHGKFVIHPFNGRRIPIITDAITVDMEFGTGAVKITPAHDPNDFECGQRNNLEFISLMNDDGTYNENAAPYQGKKRFHIRNEIIAALKEKGLFVEQKDNEMQIPICSRSGDVVEQILKPQWWISCKPMAEEALKRTRAGELEIKPKSSAGDWIRWMENMQDWCISRQLWWGHRCPAYLIKYDGETPDTADDKNWIVARSAEEAEAKAKEQANGRKYTLEQDGDVLDTWFSSGLWPFSTMGWPEKTADLEHFYPNSVLETGWDILFFWVARMVFFGNALTGKMPFKEVYCHPMIRDAYGRKMSKSLGNVIDPLDVITGQNLQKLHNDLRLGNLPEKEIVKAEEGQKKLFPKGMPQCGTDALRFTLCNYTSGGRDINMDIGRVEGYRKFCNKLWNATKFCLFRMDLVDLNGVRQQSTFVPNASPLPTGQEGLVEKWLFHKYNIASAAISKSLEAREFADATNTAYQYFLNDLCDVFIEATKPLFESNASEATRLSAQNTLYTCLEGGLKLLHPFMPYVTEDLWQRLPRRQGDECESIMLASFPEYISQQEFPQAAAEFDTVVDCIKAARSIVGLYNLPTNGKTIEDKITVIVQAKNQQQRQLLESQEPIIIGLTKGCGTAKFISDDSEVPKGCGTEFVTSDINVHIPVAGKINASAEIDKLQKKEALAQSNRNKIQKLTEQPNYQTTLKEEVRISNSEKLSSLESEIETLRLSIERFKSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L309</accession>
    <name>A0AAJ8L309_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Short coiled-coil protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_102115</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Positive regulator of amino acid starvation-induced autophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
            <location evidence="4">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SCOC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC68192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008237.2">
        <property type="nucleotide sequence ID" value="XM_019158491.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L309"/>
    <dbReference type="GeneID" id="30175161"/>
    <dbReference type="KEGG" id="kpin:30175161"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019357">
        <property type="entry name" value="SCOC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21614:SF0">
        <property type="entry name" value="GEO08385P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21614">
        <property type="entry name" value="SHORT COILED COIL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10224">
        <property type="entry name" value="DUF2205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC68192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="91" mass="10229" checksum="02D7A2B140ADB289" modified="2024-07-24" version="1">MSLSNYPESGIEEPWSTPSTIDIPEPTVESALEKEKIIKDILQLRDGLRGLLIRITEIETDNEKLAKDNEMLSLYIDNLTRNSVVAAGTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L3S5</accession>
    <name>A0AAJ8L3S5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transmembrane protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_102331</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058644.1">
        <property type="nucleotide sequence ID" value="XM_070202543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L3S5"/>
    <dbReference type="GeneID" id="30176070"/>
    <dbReference type="KEGG" id="kpin:30176070"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1740">
        <property type="entry name" value="Transmembrane protein 14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005349">
        <property type="entry name" value="TMEM14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044890">
        <property type="entry name" value="TMEM14_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03647">
        <property type="entry name" value="Tmemb_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC68405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="11505" checksum="2DB2BA1FAA348F0B" modified="2024-07-24" version="1">MSHKPIATLSGFSLLGGIFAYTKFNSVPSLVGSFAIGSMMLLSSMRIRDGMEYGYEGAALSSAALVAPTLRRTIRTRLPIPATICILATASTAYYVKALSEFRRHAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L417</accession>
    <name>A0AAJ8L417_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_102705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058708.1">
        <property type="nucleotide sequence ID" value="XM_070202607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L417"/>
    <dbReference type="GeneID" id="30171427"/>
    <dbReference type="KEGG" id="kpin:30171427"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032854">
        <property type="entry name" value="ALKBH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212:SF4">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="280"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="456"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC68770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="523" mass="58182" checksum="BE519F047D1E9DCB" modified="2024-07-24" version="1">MDGAGSKDDEEDTDTKLALLSSLLEPISIPFEQLLETLNEFDGDVAKAAEALLIPKVRNAGKRKAGASLSSWLKKPKTEISGTSKSEVIDFNETDEEPFKSLKREYEVVESQVGEKIDNPSKISLPVTNVDLLSILRGPSNTTLPKVKTGPQPPITLATQKSIDAHGLPITLLESPLPPSLASALYLELMEESENWYHNEFYLAGKAVKSPHTVQMYKYPNPKSNAWKEGVKYWYSGTSMNNIADYPPLLRKAADLIEKSVNESLNKRKRFELEWAGDWKANCCGTNRYDGAKSSVGWHADQLTYLGPYTTIASLSLGTPRAFRLRETNTVDSNFASSTKPIRTYELNLGHNSLCLMNGGCQERFKHTVPPQKALDLYRPSFDKAETPIPLCDQKTYTSRINITFRFYRDDFHPEPTIGPYGPREGTPLCKCGIPTLLRADQKAKARTRLLPPSPQKSSSTSADSAGAGLCKEKGDDFVIDDMLYFWQCQSPAKTGDMKGCGFFKILDMKKEGRGPCLKDRQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L4C7</accession>
    <name>A0AAJ8L4C7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_102856</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058741.1">
        <property type="nucleotide sequence ID" value="XM_070202640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L4C7"/>
    <dbReference type="GeneID" id="96955719"/>
    <dbReference type="KEGG" id="kpin:96955719"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="151"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC68920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="36773" checksum="E371BC21236F1F7F" modified="2024-07-24" version="1">MLRSLLYSHFSESLSGLATIRAYGETDRFIKDNAYYMDLENRAYLLSATNQRWLSIRLDFLGACLVFAVAIMSAKGGGGLTASQIALCLTYLTSITQVLGMVTRQSAEVENNMNAVERVLWYADATSLPQEPAHVIASTQPTESWPQDGAIEFKDVVMSYRPGLPPVLKGLSMDVRAGEKIGIIGRTGAGKTSITVALFRLVDGTLRTNLDPFDLHQDATLYDALTRSCVITSQGENDNKRLTLDSVIEEEGQNLSVGERSLISLARALVKNSKIVVLDEATAAVDLETDSRIQQTIHREFRGKTLLCIAHRLRTIISWDRILVMNAGEIEDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L4U2</accession>
    <name>A0AAJ8L4U2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_103377</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the proteasome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013548.2">
        <property type="nucleotide sequence ID" value="XM_019153387.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L4U2"/>
    <dbReference type="GeneID" id="30169987"/>
    <dbReference type="KEGG" id="kpin:30169987"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03762">
        <property type="entry name" value="proteasome_beta_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000010">
        <property type="entry name" value="Proteasome subunit beta type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF0">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE SUBUNIT HSLV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6 10" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC69438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="235" mass="25354" checksum="16A7E07F80161612" modified="2024-07-24" version="1">MANIHTVDITRLKNGEVNLGTSIMAVQFDGGVVIGADSRTTTGAYIANRVTDKLTHIHDRIYCCRSGSAADTQAVADVVHQHAQVYTAVYGAPPTVSTAAALFEKMCYDNKDQLSAGIIVAGWDKESGGSVYNIPLGGGMFQQPWAIGGSGSTYVYGYCDATYREGWNEQETVEFVKNTLALAMSRDGSSGGCIRMCVITKDKVERHFIPGNELPRFWEGKEIIGSVNKQQVVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L4X7</accession>
    <name>A0AAJ8L4X7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA helicase CHL1</fullName>
            <ecNumber evidence="17">5.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">ATP-dependent DNA helicase chl1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Chromosome loss protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18 19">DNA 5'-3' helicase CHL1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">I206_103118</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M. May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres. Has a specific role in chromosome segregation during meiosis II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="17"/>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058785.1">
        <property type="nucleotide sequence ID" value="XM_070202684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L4X7"/>
    <dbReference type="GeneID" id="30170247"/>
    <dbReference type="KEGG" id="kpin:30170247"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034085">
        <property type="term" value="P:establishment of sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001372">
        <property type="entry name" value="ATP-dependent DNA helicase chl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002669">
        <property type="entry name" value="Chromosome transmission fidelity protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF41">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE DDX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="22">
        <location>
            <begin position="17"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00045008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00045702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="WWC69182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="879" mass="99324" checksum="2B167331691C3910" modified="2024-07-24" version="1">MSDSQSSALSSIRLPTPTSFPFPYPKPYDIQLDLMQVVFRAIEDGKIAIVESPTGTGKSLSLLTSTLTWLNQHTKRLTEVYTEQLKEKYMDEKNDLNEPKWVIEHSIKMKLDEMKLIEEARLERFSKAREREKKIRRKMNLNKGLVIKKIKSMNDLDKKIKEIKDENDFLPYENLQNGEEDGLYLSKEVRELMEKYESTRPKAKQEEIEEEDLPKIYYTSRTHTQLRQLTSELLKTSFPLKEDDLDNNAEAGPSTTKGVSLVPLGSRKQLCINDKVRSLAKNGGDERMNEACLDMQKSGKTRCEFLPTKAEEGIMLDARDAVLASVKDIEDIVAIGRKSCVCPYYATRRAVKQSQIVTLPYNLLLQKNAREALNINLKDQIIVIDEAHNLIDTLLSIHSTTLTSTTISSAISQLQQYLARFKNRLKSIHSLKIRQVLSLLNGLLSVCQNFIGNDEKGKSKIKHEVLNVNDLMERIGKGNDQLNPLELVEYLKESKLARKISGFSEYIAEQNNAKEEKASRTSSQRHASIASFHIVEAFLLSLVDARDDGRVILSSEDKNGSRTVIIKYVLLNPAERFKQIVEEARSVVLAGGTMEPISDFLQQLFPQIPKNQFSTLSCSHVIPKENLLTQVVCVGPRKTEFGFKFYNRENDLLLTELGSVIQSVIGLVPDGVVVFLPSYAFLDKVKSIWTNSGLMSKLGEKKTLFFEPQTSGDVETTLRDYALAISTVSLGGERSKKTGALLFAVVGGKLSEGINFSDSLGRCVIMVGLPFANVGSIELQERMKYIENLPGNSKESSREMYENLCMRAVNQSIGRAIRHANDYATILLVDKRYSTTRIKNKLPKWIGEDIKIQSDFGSVAKNIALFFREKREKEKGMKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L6K6</accession>
    <name>A0AAJ8L6K6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED6</name>
        <name evidence="10" type="ORF">I206_104021</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L6K6"/>
    <dbReference type="GeneID" id="30172773"/>
    <dbReference type="KEGG" id="kpin:30172773"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.580">
        <property type="entry name" value="Mediator complex, subunit Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007018">
        <property type="entry name" value="Mediator_Med6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038566">
        <property type="entry name" value="Mediator_Med6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13104">
        <property type="entry name" value="MED-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04934">
        <property type="entry name" value="Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="172"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC70075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="368" mass="41399" checksum="ECECF0505A5D5F40" modified="2024-07-24" version="1">MADSNEEIDQNLSHIHWSWPEAIAANPARSLANADLAMDYFAYSPFWDTKSNNNVLRTQRRVENPTYGHAEEKIELNAFKSGFEYIISHAQPPDLFVIQKREVENSGKRDRVTGSWFILHEKIYQSPSIYDVVSARLRNASFLISKTLNSLSECHPSSNPRTTTVWRSLPPETEIENTTSKEIENDLINTADDIDGNEGKNKKKENSSTSTTNTTTFDWNLYHSLQTTRNSIESLNKLSKTKKNLKPNPIEEIKSIENQLSSQFGIGLQQQQQQQQFIQGQVNGINRTESIKSINTPINFNLAGIGNVISPSSIGFGNTIPNLNNFDISSSSPKILNNGISPNFNNNNNRTISLNGNSPLPNTYFNFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L771</accession>
    <name>A0AAJ8L771_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_105893</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC71934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059308.1">
        <property type="nucleotide sequence ID" value="XM_070203207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L771"/>
    <dbReference type="GeneID" id="30173082"/>
    <dbReference type="KEGG" id="kpin:30173082"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF7">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="62"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC71934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="658" mass="74019" checksum="E7DD42AEEEE990A4" modified="2024-07-24" version="1">MESHLDRKNDNQKSHRRRKDGCLTCRQRRVRCDRAKPLCGHCERLNRVCRWPELIDTCDSSDFPATKRNRVNRQGSVVTTHSRTASSRGGSGPSPQDSFQHPAENLIPWATPLSNLRGGDEARTDHVQLGLHTFIQPDQLFSDVQPQSQSTSHPQEPLSDPPGLASFDNFISPIDGGPGLASTSTSNVFDLGPIETTQQPFDPFIGHDLNLDLFLGLNDPFPWQSFPTTHEDSLFNNQNAFFPSLNAITSESPTIRRRFCSPVTPDMVDQSIATYFVERHLTTNYYISLFAASQFCPALYAGMLAWSAWHMAATGHMNPAQRQEHLEYAQHKHTLCGELLFKDLDVVQVDSDTELEAVYCTFMVYGQYASVTCAPLSRLRSLIDEVDKIFLRRPLDHTSSPLIKRMASILAQYDMKSSLFGLSEPRYTLHLGTAIFENRPATVDENTTTAFSIVSPLHMLYLSAQCCVIEGQLRRSRSAHDVIGARKIIRLGDELYDKIINLESKLDSSRLDWFASKLHDPREGTGSPQRHISHDTRFEIMLACSYHGVVIQLARVLNYPSPIRSIDRIIWMTINLTRRDPDCIHSTVALPLFFAALETGDPDKEILSWFDASDTGASGAVRVQRTKQLLEAVKRAEADGTRSDVGQIMRRTNFDTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L825</accession>
    <name>A0AAJ8L825_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_105041</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC71088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059153.1">
        <property type="nucleotide sequence ID" value="XM_070203052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L825"/>
    <dbReference type="GeneID" id="30170950"/>
    <dbReference type="KEGG" id="kpin:30170950"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14014">
        <property type="entry name" value="STKc_PknB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF68">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATG1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="167"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="620"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="707"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="764"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="871"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1063"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1210"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="764"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="809"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="878"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1102"/>
            <end position="1117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC71088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1277" mass="141107" checksum="E9FF06FE09481E12" modified="2024-07-24" version="1">MVNTQPKLYKPKSKIRLRLGLGSPSQPQTKPHQQHLSPNPSPHNELASSTSTNTSSISRTDSRSAFTYDFTLTPSPPNKEFDTISYNTISPESQLYQNSSSNVQSSSTLLTTSESNDDDGEYHVYPNQEDQYEEKEVEDTLHPAISSITSGTDDIFCLTDQQLTDGFTFIREIGFGNWGSVWLCKPKHHKHLLNQGRLSTNERAIVKLGKKSILTAGSGAGGKVAIKLVHRSKTPTTAARVRALWGEMKIIRSLRHEPHPSIIQFEAFVITPGYALVIMPHLAELIPVCLPPWRATPYFRQLASAVGYLHERGITHNDIKPANVLLSHNDIPVLVDFGFAQQWDVGARGSFLSSISWGTPEYLDPIRAKGMPHDERASDVWSLGITMFEILIGRTPFEENEAEQFQTPKELLVYYERSKRGRWVGEWSMPEGLENLLRYMICPDPAYRISAMQAYHHPALQPEAPSVIITPHFVRAAATSEGYENEPIPAPPVEYTEAVTAANEKKKKRKVKKDGHNVHKEKDATRHSHRATTPALGESIKQHTSIPKNYHAKGGDEDKENVDEKERLSKLIIRKRESEIKDKDDENDDPTPTKVGKPAQPLRIKELSLIADKKVVPRTSNSNLTNLSRPASATSHNTRQAVLSSSTSTSTLKENRISVLSASSTVPKSKEEAVLRTMRSLEGTRKIVHTHGNDKKEKAAEAIAAIKRHAPEPPRSKSLASADDLTHQKEDERRILGLERAVLVDVREEEVDIKVKEGGREVDTVIHFNQHDQARPMRTAEPMSPPRDKRSSANRQPTPSPQKTRRTGRKAEAEMDTLRGKVFPASDDESPLSELRDKILVSDKEKAVRYRQVSGGDQMEILAPPVAAPEGNEETAHATATQKDVRNSVDSYASTSASQGGLTRARSVEALQMDDRLDKMSSWIKSVESIIEDARRAIAEGREPPLPLLSLPKEIQVAAEDQDIQKHFGLTPDKAIPVHLRTSSTQVEPSTPSKWETGVRAMDIKEAQEKVLAANEWLEEQSRKSKKARPTVSHVLKLFGTEKERPLSGSRSNTPDIAQLVPLKPPATTPSHALKGAPSTPALRSSTTRGLTKVPQRKSESNLRNFNTMPTIPSPSFTAGPEYDPLSMSDEDDLSPSSPRRVMFENLIANQPGVVRQGDGWGSLSSGKGFMMGVKPSSSMASLREKARALLGDGSATKGERNITDLSKVGGHKVEKRSSKLNLQTAVEKDSQPPRPNTPGAASVLTLKNAEHKKGWLKSLKGAMGMSKKTGQVDQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L8A1</accession>
    <name>A0AAJ8L8A1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_105146</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059169.1">
        <property type="nucleotide sequence ID" value="XM_070203068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L8A1"/>
    <dbReference type="GeneID" id="30172313"/>
    <dbReference type="KEGG" id="kpin:30172313"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006181">
        <property type="entry name" value="D-amino_acid_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF30">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00677">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="3"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC71193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="388" mass="42205" checksum="9E4592CD13E3D0C9" modified="2024-07-24" version="1">MYDAIVLGSGVVGLSIALELHSRGIKVAVVARDIAEDSTSIGFASPWAGCNWFSFANGLSDPAAEWDRITYHGLDKVAKERPDLCEKVPVWNVLEKRKGPAEALWYKDFVTNYKDLEGSSSNPLPGNKPFANYFETWILHAPNYTRYLGEKVKSLGIPIIRHRLSSIDEAYNLPSTGKVSLVINATGLGSRSLVGVEDEKVYPARGQTVLVKAPLVRECIFHVEGFFAETDDDKDETAKAPPQAAYMIPRPGPEGHVVLGGHYRVGDWSTNADLKEAERILQDCYKLCPRLAGPNGKSWKDIEVVSHNVGLRPAREGGARMELEEKRIGQVGSQNLIPGSVNSSKGRKVGVVHAYGVGGAGFQNSLGLAEKAADLAIKYLGHQSIAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L8I8</accession>
    <name>A0AAJ8L8I8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_106633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059461.1">
        <property type="nucleotide sequence ID" value="XM_070203360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L8I8"/>
    <dbReference type="GeneID" id="30175845"/>
    <dbReference type="KEGG" id="kpin:30175845"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="301"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="381"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="506"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC72669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="544" mass="58911" checksum="E1E80D4D8494B7E2" modified="2024-07-24" version="1">MPNSNKMAPHSSISPSFNSISPKPPAPDPNINPFSPLSPDLPENRLRARNADGEVNRLLGLLTMHQQPIIYTRKQLLRIGKRSHQRGPPPGMGPLETWYGPPAGSSSRRGGFGEGFGFGGGIGGSNRGLGGRGGRNIGSHGGQMGRFSVRTPANPTMRLGGEEDRRREDEWRRPDRENGRMPRDTRRPNYQDESVEPAWMDDVAPADPAIVDNTDPLVQFVPGEDMIAAHKRAMKARDVGNDWRGDSGGLPPFFGGGDPAIASSSVPSGPPPGLKPKSFNAADYLKQAQDISDEETAPQKSPHAAPASAFSSRFQKFFSPPTANAAPVVEPRPVDEVKGDRTAMLMGMLSSKPNPPAEHVYHPSPNEQYRHLSSPPAAEGPPSHLSPSFYHSSRSSPPPPAPQANALLQQLYGNTQDRQNAPDPLQLLNQAQRQGYQQRPPHMSMPPQFARPPPDMYMQEDSASDSYNRQLSPTHFPNGPPPPGFMPPAPPAFFQQGPPRPPGYHPVPNYHPAQRAGPPYPPPPLGPAQQDMLATLFAGLGPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L9M6</accession>
    <name>A0AAJ8L9M6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_106741</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059490.1">
        <property type="nucleotide sequence ID" value="XM_070203389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L9M6"/>
    <dbReference type="GeneID" id="30175740"/>
    <dbReference type="KEGG" id="kpin:30175740"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000004">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570:SF16">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="554"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="27"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="290"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC72777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="573" mass="62954" checksum="F65D448256C1F65E" modified="2024-07-24" version="1">MSDLEASVNGNGIIHEGDIPKYEPTSIDQIDKIYTTLNERFNSGKTYSLAYRLYNLKQLAYLIKDNEKRIHQAVYKDLGKGAFDVSLGDLWPILNEVDLAVRRVKGWMKDESRIWDAMLSFKFMRPRVKKQPKGPVLIISAWNFPWQLTLIPLVGAIAAGCPAVLKVSEHAPSSSALLAELLPRYLDPEGYAVVLGAVEESTKLLEKPWGHILYTGSGNVGKIVATAAAKTLTPSTLELGGKSPVVVSSCANVKIAARRMFTIKQMAAGQCHRLCIRYAVSHLRHDATADQTIANGNDRSVAPDYVLVVKDKVDEFVEACKETLDSFFPPSPSPLSFLHTPQSSSMRNDADLDRMISYLDKADGEGKLVNRGELNKESRRLGISLVKTNLNGEGETGGLVEDEVFGPVIAIIPVDDIDTAIKYINARPHPLALYVCSGKRSVFTKVINETCSGSATWNDFGFATLARNLPFGGAGASGWGSYHGKDGFDTFTHHKAILEIPYLFEPLMSLRYPPLSNAKKAVFKFLLCSGISFSRPVSVEGEEGKLKTRKVVKWMSTILVGLVAAYIGGLRWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LAP0</accession>
    <name>A0AAJ8LAP0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTP-binding protein ryh1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_106654</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007821.2">
        <property type="nucleotide sequence ID" value="XM_019159149.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LAP0"/>
    <dbReference type="GeneID" id="30175824"/>
    <dbReference type="KEGG" id="kpin:30175824"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01861">
        <property type="entry name" value="Rab6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001461">
        <property type="entry name" value="GTP-binding protein ryh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC72690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="23799" checksum="FFD75B4894B42C93" modified="2024-07-24" version="1">MSNPQTPSSAGDFSSASTPLRKFKLVFLGEQSVGKTSLITRFMYDTFDNTYQATIGIDFLSKTMYLEDRTVRLQLWDTAGQERFRSLIPSYIRDSSVAVIVYDITNRTSFLNTTKWVDDVRNERGQDVIIVLVGNKTDLNDKRQVTPEELDSRAKELGVMSIETSAKAGYNVKALFKKIAMALPGGNSEAKETANTKIDVSATPQEVPQASGCSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LAY7</accession>
    <name>A0AAJ8LAY7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isochorismatase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_107439</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009121.2">
        <property type="nucleotide sequence ID" value="XM_019157481.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LAY7"/>
    <dbReference type="GeneID" id="30174135"/>
    <dbReference type="KEGG" id="kpin:30174135"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050993">
        <property type="entry name" value="Isochorismatase_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119">
        <property type="entry name" value="HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119:SF3">
        <property type="entry name" value="ISOCHORISMATASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="2">
        <location>
            <begin position="7"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC73469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="197" mass="21753" checksum="3085AC1DCFCB42A3" modified="2024-07-24" version="1">MAARRPLLLICDVQDRFRTAIYGFDQMKNTICKMLKIAEVLEIPTLITEQNPKALGATINEVTDLINPSRHLGTFSKTKFSMVNENTKALLEKDNHNMYIVTGIESHVCVLQTTLDLLKLSTKPDVYVLADGISSCNKPEIGISITRMEKAGAIVTTSESIIFELLGDANHDKFKKVAGIIKQTKAQTAEALESLCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MLG7</accession>
    <name>A0AAJ8MLG7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_101748</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKN1/KRE6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008605.2">
        <property type="nucleotide sequence ID" value="XM_019157992.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MLG7"/>
    <dbReference type="GeneID" id="30174651"/>
    <dbReference type="KEGG" id="kpin:30174651"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02180">
        <property type="entry name" value="GH16_fungal_KRE6_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000140">
        <property type="entry name" value="Beta-glucan synthesis-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000135">
        <property type="entry name" value="Related to KRE6-glucan synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF15">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="11">
        <location>
            <begin position="193"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC67831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="622" mass="67839" checksum="173770EEEDDA14AA" modified="2024-07-24" version="1">MQYGSQSPSLGREPLLASAQTPGMSQRLSESSLASYERSHSQMSHRGQTANSAGQSYASFSSGNRFGPTANIGSTTTPSSAASDAALTKGAYATGGLDDDDDLDDQLHTFTAAERKDLNTPFDIASWRGWANALTLLLLALGGIMLFAGYPIIAWYYGNSNSSGANTSGYNLGGINASGQYPSITGLPSLIDTDTPSDSYTKTGADGNTWDLVFSDEFNKDGRTFYDGDDPFFQAVDFHYWATGDFEWYDPSAATTADGHLILTMTQEPIHNLNFKSAMLQSWNKLCFNKNAYIEVSASLPGMTTVGGFWPGIWTMGNLGRPGYGATTEGTWPYTYDSCDIGTLANQTYVNQTGPDATLTTGSNSGPLSYLPGQRLSACTCAGEDHPGPNVGVGRGAPEIDMIEAQVILSEERGEVSQSFQVAPFDDYYQWDNTTTANWKQYDTSLTYWNTYLGGSYQQAVSALTRVPRDIYYSQSGANQQFTTFGLEWQSYPDNRENGYIAWYSDGVPSWTMHADAVAANPRVGIGRRIIPEEPMALVFNFGASNNFQAVDFDNLVFPNYLRIDYIRVYQRTDTGSIGCDPSDYPTADYISRHAEAYSNANLTTWAAYGQTFPKNSLKDTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MM64</accession>
    <name>A0AAJ8MM64_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitotic checkpoint regulator, MAD2B-interacting-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_101174</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058441.1">
        <property type="nucleotide sequence ID" value="XM_070202340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MM64"/>
    <dbReference type="GeneID" id="30168520"/>
    <dbReference type="KEGG" id="kpin:30168520"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018800">
        <property type="entry name" value="PRCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13621">
        <property type="entry name" value="PROLINE-RICH PROTEIN PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13621:SF2">
        <property type="entry name" value="PROLINE-RICH PROTEIN PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10253">
        <property type="entry name" value="PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="353"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="134"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC67266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="42232" checksum="2F3F13B29CA5CD46" modified="2024-07-24" version="1">MLLANYASDSDSDAGSDIEASSSKISAPAPPLAPKPVASTGTVKAPINKAKKPVKITLGLPKSSDHNGELVKDVQNGIDGDIDEEREVKKSKITGGKGSSSLLGMLPPPKRKLPQASTSKASSLKVNRSMANPSSSSSSSSLNPKTNPKIKIPKPLLSSTKAAEAAGAFDDNDDDEDDDDKEKSLPPSLARKAQKKKEEESFDLFGLSSSTAEITLPSTSVSSSSTIKPPTISSAPLAPDYIPPEPTSNDPYPGYYKLPSGEWKAYDPEYYNSFFTSNNNQEEEEEDGRVGKHWKEFNDGQFKGNLLDVNATSGIAEARAQEQINNMAKRQKVNENEFEYKPIGQVKGLASQRHQLTSLLNTAYTQREELEDRIAQNKKNMRMAGTKYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MQ72</accession>
    <name>A0AAJ8MQ72_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_103787</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC69844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058932.1">
        <property type="nucleotide sequence ID" value="XM_070202831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MQ72"/>
    <dbReference type="GeneID" id="30176105"/>
    <dbReference type="KEGG" id="kpin:30176105"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF12">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="9">
        <location>
            <begin position="363"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC69844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="730" mass="81338" checksum="C1D2DB77273A6181" modified="2024-07-24" version="1">MSTSPRDLAFDSTSLIPTSYESTSAPSFTQSQQQRLSQSDFDWQSWLSTLSDEQRASLPVPQTTHNLQQQRLMDSARKSVPVPEQVSHPQFSSSLPLAQLHTETHGHANPQNTSFRQNTALHQAPSDLRSTMNQSLPPYQDMEHLLPFALPQQQSYRPPTHGHLPTSPTSGIESDEGSLEKGVAMISLEAAAEPHYVGESSGSLWTTVISGGMHSHPYQQQQQNEGLKRQGIAYRNKVEQGMEPSNIGSNDIDVLQAIQIPLSDDTSTLALETVFSHLHPRYPFMDWVRFEKQWEEKDQILRSVGQKFSMDRQESTSAFFILMVLAIAAQLNRDRPLAGLLAPQQYYELAMPYLNVIVTLHNLPNIQGVTLRLCIGMGLHRNAAGAAVRTLPKSDIEMRKRVFWSCYIIDRMISLLLGRPSGISDEDIDVDLPDSYVSIEKPKMESLQLSSMVSAIHHIKLKRIESRIQKAVYGIKRQPLQQAADYWDLLNDLDTWEKNIPLEASSPDHWQSPSCSRDWFLLKGVEARLHLLRPLCAEGQTAGAVFVTHLAAVAARGCQIQKRMHQQGLPMSNASAHSAFICGLALLYALFLQPKIMPLKDVFRAIKATSNTLFSYAQHAHQSVEVLYDVFEDLSADCIEHISKRETFEAGNPSGERRTSVVEWQKASSQATSNLDPTAAGEYVNMLEALGLTVAGDLSGQSSYTEPLWDLAAFSPGNLFPLTNDNTMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HSE6</accession>
    <name>A0A1B9HSE6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2231 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_07838</name>
        <name evidence="4" type="ORF">I206_100023</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
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                <person name="Imamovic A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
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                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
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                <person name="Heitman J."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
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                <person name="David-Palma M."/>
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                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700118">
        <property type="protein sequence ID" value="OCF46327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC69912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007546.1">
        <property type="nucleotide sequence ID" value="XM_019159494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HST2"/>
    <dbReference type="GeneID" id="30176178"/>
    <dbReference type="KEGG" id="kpin:30176178"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCF46327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC69912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="255" mass="30250" checksum="F5EC52536223BB17" modified="2016-11-02" version="1">MSECQFTLQNFTYDHNTEKFHSSTYCITLPKKITEYPNINSRNVKSGIYNSFTYVSDNMHKEFERYSLVVHSNSIYNDKQEDYYTKNRKELVDFNNSIFYSITDDKHFRESFKNGSLDKKSIEEKIQLTFEECNKNFQHIHEIDFLQFGTYDEWYKYTKTIDSPFDWNDFSDSSEDGKGGSNSQFFINQEEEEEESLLNPLLKEKVSNNTHRSKLKNVLSHIWKNHLNCFNKGSNCGYTTEGMVPRPSKLLFDQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HSX0</accession>
    <name>A0A1B9HSX0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I206_07602</name>
        <name evidence="14" type="ORF">I206_102234</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>UTP + L-glutamine + ATP + H2O = CTP + L-glutamate + ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the CTP synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="EMBL" id="KI894017">
        <property type="protein sequence ID" value="OCF46369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007588.1">
        <property type="nucleotide sequence ID" value="XM_019159294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HSX0"/>
    <dbReference type="STRING" id="1296096.A0A1B9HSX0"/>
    <dbReference type="GeneID" id="30175971"/>
    <dbReference type="KEGG" id="kpin:30175971"/>
    <dbReference type="OrthoDB" id="1739076at2759"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097268">
        <property type="term" value="C:cytoophidium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000207">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000005">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003792">
        <property type="entry name" value="PRK05380.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="CTP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550:SF0">
        <property type="entry name" value="CTP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP synthase N-terminal" evidence="12">
        <location>
            <begin position="3"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase" evidence="11">
        <location>
            <begin position="316"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="572"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU810713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCF46369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WWC68310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="637" mass="70328" checksum="189C50655EDB22D6" modified="2016-11-02" version="1">MVKYILVCGGVISGIGKGVIASSTGLTLKAAGLKVTAIKIDPYMNIDAGTMAPTEHGEVYVLNDGGETDLDLGNYERYLDVSLNKDNNVTTGKVYQHVIDRERKGDYLGKTVQIIPHLTNAIQDWVERVSKISVDGTGEEPDVCIIELGGTVGDIESMPFVEAMRQFQFRVGHENFALIYVSLIPVVGGEQKTKPTQAGVRDLRGLGLLPDLIACRCTDTLLTATMEKVSMFCHVSPKQVLGVHNVSSTYHVPLLLQQQGMLDYLRKRLNLGEVTINDKFRQKGEDFMGRWKALTVGQERLFDTVSIVLVGKYTTLEDSYMSVVKALEHASMRCGRKLELQWVDSSDLEPSTQTSNPVKFHDAWSAVCSAKGIIVPGGFGHRGTEGMIAAVKWAREQKVPFLGICLGFQVAVIEWARHVCGLDGANSAELVPDTPHPVICFMPEISKTQMGGTMRLGLRPTIFQENTESSKLRKLYGSNQVAWERHRHRYEVEPKYVDELESKDGMRFIGKDERGERMQMLELDDHPYFVALQAHPEFCSRPLNPSPPFLGLIAAACGKSELEEQILKNEKGGYIDPHPEESKTVPESEAYTEKGKNVKQNLGGIVKVKGQINGDLGMKELQLSSAGVEGEINESST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HSY6</accession>
    <name>A0A1B9HSY6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA ligase D, 3'-phosphoesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_07609</name>
        <name evidence="4" type="ORF">I206_102240</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894017">
        <property type="protein sequence ID" value="OCF46375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007594.1">
        <property type="nucleotide sequence ID" value="XM_019159300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HSY6"/>
    <dbReference type="GeneID" id="30175978"/>
    <dbReference type="KEGG" id="kpin:30175978"/>
    <dbReference type="OrthoDB" id="2588098at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014144">
        <property type="entry name" value="LigD_PE_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39465:SF1">
        <property type="entry name" value="DNA LIGASE D 3'-PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39465">
        <property type="entry name" value="DNA LIGASE D, 3'-PHOSPHOESTERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13298">
        <property type="entry name" value="LigD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA ligase D 3'-phosphoesterase" evidence="2">
        <location>
            <begin position="60"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF46375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC68315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="301" mass="34510" checksum="B92DC5F96C003504" modified="2016-11-02" version="1">MWTLHLLKNNKSKYEPQISLTEDVVHHEDKEEERIGIWGFTKTEIDRFPALKKRNFWCIQRHSATAMHYDLRMQIDGGTISWAVPKGLIGISKNGESSRLAVETTIHPISYTTYEGADGRNFSAGRKGGTLLWDIGEYLITKSSSAADSTSDEDRPSRPSKRRRKGTVESDENSEDPDGKYQEDLLRQYLHKKVGYGKSRSIHFVLRGGKKMTNHHFILVLAASHAHTFSASGQIKKTWFLRLPKEVDEYPWDQGGEEGDFWGRSVKTGRTLKEVTAGYVARPERWKKEEERFASWFGDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HTW6</accession>
    <name>A0A1B9HTW6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">I206_07101</name>
        <name evidence="19" type="ORF">I206_106299</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 21">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="KI894015">
        <property type="protein sequence ID" value="OCF46714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007933.1">
        <property type="nucleotide sequence ID" value="XM_019158795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HTW6"/>
    <dbReference type="STRING" id="1296096.A0A1B9HTW6"/>
    <dbReference type="GeneID" id="30175470"/>
    <dbReference type="KEGG" id="kpin:30175470"/>
    <dbReference type="OrthoDB" id="9984778at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044695">
        <property type="term" value="C:Dsc E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021319">
        <property type="entry name" value="DUF2921"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF162">
        <property type="entry name" value="TRANSMEMBRANE E3 UBIQUITIN-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11145">
        <property type="entry name" value="DUF2921"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="463"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="497"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="607"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="636"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="667"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="734"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OCF46714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="WWC72337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="799" mass="88826" checksum="6682A29F97428CE3" modified="2016-11-02" version="1">MSAAPQDPPSGEANNQRTSPRSPRPATIPIGQPLPPELLQPQPPPRPNITSMLFLTAFFFFMSGNNQPINSGIEIGPDGEFRTRISELDHAKTIRNEWEGIVHGNITLRGNFTEPSIPLALPSSLLPPEYTYNPAHHQFFTNITGFFRSSTLHPISFDPNTTAQLTDDGYWQHHPDLNLNSTGAWNATLASELKGTWQWDKTTKWDMNLKERNISSIAPDLEDAYKANGTDWDRYQDWNWIKGSLTLSTLSSPSHTDDNGDKSELGGASINYDFFGLHYLPNGTYNLYGLPEGMRIDIRKIPSLWYGQQQQNVTKEIILRELEMEVRNIDGNLMIGDLRDDDVSDQTTCPLLIHLTLPPLPSGVTKEEIDFFNSEVQNPTGIKGAIPRPPSYWEVGRGLGGVIVADQCGWVMGIEGGKGVGIDEFWSRSIEYAAYAIISQLTVLLLLVRQMEQTRTPSSLSKVSVYTIVIMSITDSWVFSAHVVVGIMSDNKASLPMLVPGFLCLCTAVVFGPRYAVLLHRIQAPERSAAPTPARINNGQAGTGQITNTDASTALSGVELAEDGTVRRISVVASIKAFFSEHPMLRWFAVLGLLFCLLQFAFLPSVVPFFLFGLYSFWIPQIWRNARRGTSRALDAWFVLGTTVGRLALPLYAFAYTENVFFIDKASWIWGILWWQLAQVTLLFAQERFGPSFFLPKSLSPPESYNYHPILPSPTSDPEAAASFPLLSTSETTCSICMEEVDLSQSINQNHSHSTGGLGHKRKNYALAPCGHLFHTNCLSQWMAVKTICPLCKRSLPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HUB9</accession>
    <name>A0A1B9HUB9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Integral membrane bound transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_07245</name>
        <name evidence="9" type="ORF">I206_106441</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI894015">
        <property type="protein sequence ID" value="OCF46858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008077.1">
        <property type="nucleotide sequence ID" value="XM_019158939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HUB9"/>
    <dbReference type="STRING" id="1296096.A0A1B9HUB9"/>
    <dbReference type="GeneID" id="30175614"/>
    <dbReference type="KEGG" id="kpin:30175614"/>
    <dbReference type="OrthoDB" id="68611at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023244">
        <property type="entry name" value="Brefeldin_A-sensitivity_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052430">
        <property type="entry name" value="IVT-Associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804:SF3">
        <property type="entry name" value="PROTEIN BRE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02047">
        <property type="entry name" value="BREFELDNASP4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="627"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="679"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="710"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="735"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="766"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="7">
        <location>
            <begin position="656"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF46858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC72479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1032" mass="116140" checksum="6ED6A27B2F00353B" modified="2016-11-02" version="1">MDWLNRLRLLAIPTLCAFLSFVFVVIRPWSKIAGQWAFLVYTSNLIFFFPRGRISLQLEATVIGTIGGILGITWSTATLAIAAWCGRKYGSDSAESRAILGLGLALLALIVGFIRNKYRRLNAFSKIAIFFPIFMLTSQQSITHLTPAHFLQQLYVIIFSAVFALIPTLILAPHQSSDQLGLHINNTVETICSLLPLSISSLLEIDHQNPQATQGIPPNLKNELEGQPQLSEASHQDRLAKQLKNEVANLHISSSSYVRESKLLERQSASLLSVIKALQCLQRNPLLGQTSHAPGERIQAALQKSFPPSRPSSAAGTPKHRRSLSSIRRQSRLSISADREYPLNDLGHRLRHLTSDYGRPSDSNRSIPLHTKPDLKIASQHLVEAIVVSLQIVNLTLMEKFHWSAGPQGAKPEKNREDLFDAKVTLEDVLSDVQRALGTLLSGSTKGLETDHSQTASLSATLISHTHPHIAFSENTDVTDLLQNKDRFRLAFYMTALLDLARDVHGITNTVIGMGEREITPFSWMAIFRLGWMRHDKDEDNAEPEGKAVNETDLVMEQEQPKDETREYQDMDFVTATLHHRRSPVVEHGDMRDGLARAWRRIWDNHRIVKSRILLSRFLHQTKHSRHVLFSLKMGLGISLLSIPAFLPPDHAGRKWYDSSRGGWMVVSYMFVLEDTTGAILKVGFLRGLGCLIGAVVGYVCAIIARENPYALVVLATACTIPISWHILFNTSTPGLGVSIGITLPPLLFITYLNESHGQSYFTLTWNRFVDIMIGTAAAVLFGTFVWPVHARVQYFRAVGGTMDRITEFFDWNFRDLVRSSLVYRVDDKQYDDLEAKIRREFALSRTLISIQRQEISLLPRPVKLYSEIIDASERLLETLVEIRLLRFSVPRKATVLDVLPIRRELISTVLINLWACAHSFHSRSPLPQFLPTPRSPLSELMEVTDQHARDIRCFKDTYSNEERNRGRNRSISPNIAMSRSGSQQKIDYQAEMAILYAMAENEALGEVCNILEEIVASAKTLFGTQTFLDTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HV51</accession>
    <name>A0A1B9HV51_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_06928</name>
        <name evidence="3" type="ORF">I206_101980</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700117">
        <property type="protein sequence ID" value="OCF47150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC68061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008369.1">
        <property type="nucleotide sequence ID" value="XM_019158623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HV51"/>
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    <dbReference type="KEGG" id="kpin:30175297"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF47150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC68061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="154" mass="17148" checksum="B40B3AF76558B7F9" modified="2016-11-02" version="1">MSQTTDQELQMKVSQPDRTPSLTTHAATTSGEGVDDTPTRDERSSTNHSWNTRCPICNSYLDSESARVPASDRSNSFIGGIHDTIINYCTHILSKIKRESSTDNQDVSNQTQSDNLQSSSEVSEIQTQDKVKKKAVSPNFPEFRRRPADVTPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HV54</accession>
    <name>A0A1B9HV54_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ca3427-like PBP 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_06921</name>
        <name evidence="6" type="ORF">I206_101987</name>
    </gene>
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        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
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    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial solute-binding protein SsuA/TauA family.</text>
    </comment>
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        <property type="protein sequence ID" value="OCF47143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC68068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008362.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HV54"/>
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    <dbReference type="KEGG" id="kpin:30175290"/>
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    <dbReference type="Proteomes" id="UP000094020">
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    </dbReference>
    <dbReference type="GO" id="GO:0042597">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR30024">
        <property type="entry name" value="ALIPHATIC SULFONATES-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30024:SF47">
        <property type="entry name" value="TAURINE-BINDING PERIPLASMIC PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF22384">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Periplasmic binding protein-like II"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="84"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF47143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC68068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="292" mass="32746" checksum="0494C5A171A55814" modified="2016-11-02" version="1">MTKLKVGWHREHFLSPLLQFASQDKNETFELVECPGGTGEMQVKLKSGEIDLCIALTDALIAGIANGQTSYKLVGRYIASPLRWAIITGKESKYNSVDDLKGTTFGISRLGSGSQVMASVLSLNQGWTENEQPKFKVNGQFKPLRDSVNSGETSVFLWEWFTTKPYVDSGEVRFIGSVYTPWPCWHIAASPTASSEIIKKFLSSLQPYVQHFNSAEAREKEDINFVHSYFGHDEDDVKEWLKSVKWEDQLLEVKEDVVRETLRVLAQAGVVKPETETLDISTFVNTDVASIV</sequence>
</entry>
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    <name>A0A1B9HVW7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
    <gene>
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        <name evidence="2" type="ORF">I206_101718</name>
    </gene>
    <organism evidence="1">
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        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008634.1">
        <property type="nucleotide sequence ID" value="XM_019158021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HVW7"/>
    <dbReference type="GeneID" id="30174684"/>
    <dbReference type="KEGG" id="kpin:30174684"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCF47415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC67805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="79" mass="8627" checksum="83B9224DA2327D03" modified="2016-11-02" version="1">MRDAKTYRLYTIACSYHRSLTAVFLLCIVGGGLDAGAKVKIFILTFAVNGGNGKEREFPTWWGNPVASSKQYANYCGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HW27</accession>
    <name>A0A1B9HW27_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondrial fission process protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mitochondrial 18 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_06375</name>
        <name evidence="6" type="ORF">I206_101655</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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                <person name="David-Palma M."/>
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                <person name="Bowers K."/>
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                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
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                <person name="Young S.K."/>
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                <person name="Gargeya S."/>
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                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
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                <person name="Imamovic A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
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                <person name="Imamovic A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Murphy C."/>
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                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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    <reference evidence="13" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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    <reference evidence="12" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="12">CBS 10737</strain>
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    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
    <comment type="function">
        <text evidence="9">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. A MMM1 homodimer associates with one molecule of MDM12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of MMM1 and MDM12 generate a continuous hydrophobic tunnel for phospholipid trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Mitochondrion outer membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="9">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the MDM12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008800.1">
        <property type="nucleotide sequence ID" value="XM_019158187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HWD9"/>
    <dbReference type="STRING" id="1296096.A0A1B9HWD9"/>
    <dbReference type="GeneID" id="30174853"/>
    <dbReference type="KEGG" id="kpin:30174853"/>
    <dbReference type="OrthoDB" id="3356905at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03104">
        <property type="entry name" value="Mdm12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027532">
        <property type="entry name" value="Mdm12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28204">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28204:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26544">
        <property type="entry name" value="Mdm12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SMP-LTD" evidence="11">
        <location>
            <begin position="1"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="163"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="14"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCF47581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC67633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="515" mass="58740" checksum="BBB70A2A756272E4" modified="2016-11-02" version="1">MSVDINWSLLNTPCDSSTSTGNSNPIPSTSRNSSGQYSNTEEYEEITNELSESLIILLNEQLQTSKRPSFIGPITVTSFSFGDLGPDLEIKDIRDVWRVFDQGDEEGDELQEKLEKEELIKKVKEDERHRIEKMGVESELDEENYEYINKDFLNKNKNENENENQLLSRGKDSNEHSNSIKYKKPGISHKSISNSNNLITERERSKSGSTINSGKSYIPFHFDPNSSSLNINSNSNSNIYEGLKNNSSSLLFSPGLGRRSNSIASFPRQTTQSILGRNDLNQNLIKELNNNQEETIDTKQNHNQDEIELNLSNSSSSSPPAQISNKISNESSIRKNSKMNLPSIQLHLNLNFKSNLNLTFITSLQVNYPSNLFMSLPLKINITGFEIKNEIILAYSNEKNRLHLTLLNQEFSNNDNNNNNNEEDENEFENDLNFKGEKNLRRNSIFNNNNNNNNDYEKIPIGMKILKNLQIESEIGHSDVHVLRNVGKVERFIVDVIRKTLVEELVFPNFHTIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HWG0</accession>
    <name>A0A1B9HWG0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">KRR1 small subunit processome component</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">KRR-R motif-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I206_06493</name>
        <name evidence="16" type="ORF">I206_101535</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. Essential for vegetative growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. Interacts with snoRNA U3. Interacts with MPP10, KRI1 and with ribosomal proteins RPS1A, RPS4A, RPS4B, RPS8A, RPS8B, RPS11A, RPS11B, RPS13, RPS24, RPS25, RPL4A, RPL7B, RPL8, RPL23, RPL25 and RPL28.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
            <location evidence="1 11">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the KRR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008809.1">
        <property type="nucleotide sequence ID" value="XM_019158196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HWG0"/>
    <dbReference type="STRING" id="1296096.A0A1B9HWG0"/>
    <dbReference type="GeneID" id="30174862"/>
    <dbReference type="KEGG" id="kpin:30174862"/>
    <dbReference type="OrthoDB" id="441223at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22393">
        <property type="entry name" value="KH-I_KRR1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22394">
        <property type="entry name" value="KH-I_KRR1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000011">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000014">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041174">
        <property type="entry name" value="KRR1-like_KH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048550">
        <property type="entry name" value="KRR1-like_KH1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048548">
        <property type="entry name" value="KRR1-like_KH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048549">
        <property type="entry name" value="KRR1-like_KH2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024166">
        <property type="entry name" value="rRNA_assembly_KRR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581">
        <property type="entry name" value="HIV-1 REV BINDING PROTEIN 2, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581:SF0">
        <property type="entry name" value="KRR1 SMALL SUBUNIT PROCESSOME COMPONENT HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17903">
        <property type="entry name" value="KH_KRR1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21800">
        <property type="entry name" value="KH_KRR1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006515">
        <property type="entry name" value="KRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 11" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="K Homology" evidence="14">
        <location>
            <begin position="156"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="351"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="19"/>
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        </location>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009344"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HWI2</accession>
    <name>A0A1B9HWI2_9TREE</name>
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            <fullName evidence="5">Amidohydrolase-related domain-containing protein</fullName>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
    <reference evidence="2" key="3">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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            <end position="34"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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            <dbReference type="EMBL" id="OCF47636.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC67578.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="34914" checksum="CA3B482C4E5ADBC6" modified="2016-11-02" version="1">MRSRRPPPLPKSLFAPQGQLSPNSAPLPPSPSTIHPDYIIDSHSFIKKIEPTPDPIYDGLDPSFPRPPVKSAVQVKMDVSAEPAQAVLGVKPFSIHPTVLNLTLVTPPSITNIAKGAVDIIVPSTFPLSEKEWDLLDEAVDALDGCWGNHEVAGNKPVTGENGKEPGKVVISGILPPPLTQTSTPLFRSDSYNLHLARLANLSLHANVYLKALPPVVDTIQGKEVDGKWWEDRQELERVLRMYISPAIEAFGTHRIIFGSTPALPIPELSRVTPIPGELEQPISNGEWYSVLRRIVTQLGEGKEEVTGVMGGNAAKVYRLA</sequence>
</entry>
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    <name>A0A1B9HWJ6_9TREE</name>
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        <lineage>
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    <reference evidence="2" key="1">
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            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Chromosome 2"/>
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        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
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        <property type="entry name" value="GNAT_dom"/>
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        <property type="entry name" value="MshD_Acetyltransferase"/>
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    <dbReference type="PANTHER" id="PTHR43617">
        <property type="entry name" value="L-AMINO ACID N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43617:SF33">
        <property type="entry name" value="SPORE COAT POLYSACCHARIDE BIOSYNTHESIS PROTEIN SPSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="26"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF47643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC67571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="184" mass="21586" checksum="10B660848F9CEC7D" modified="2016-11-02" version="1">MSYTIRPGVSSDSKALSILLKESFYQAFRNVEGVTEEFFNNYFKTTLNPNNLKKVLENDKWTFLVAELENEPEKLQGMIQILHPNNDDNDEISFKKNLNKQVHLSRFYLLPSSQGSGLALILFEEILKICKNLKYTTMELDVLSTNYRGIRFYEKMGFKKIKEVHNEGDDKFKRVDWIMIKDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HWL7</accession>
    <name>A0A1B9HWL7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">adenine phosphoribosyltransferase</fullName>
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    <gene>
        <name evidence="13" type="ORF">I206_06566</name>
        <name evidence="14" type="ORF">I206_101462</name>
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    <organism evidence="13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="7"/>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008880.1">
        <property type="nucleotide sequence ID" value="XM_019158267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HWL7"/>
    <dbReference type="STRING" id="1296096.A0A1B9HWL7"/>
    <dbReference type="GeneID" id="30174935"/>
    <dbReference type="KEGG" id="kpin:30174935"/>
    <dbReference type="OrthoDB" id="363185at2759"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002055">
        <property type="term" value="F:adenine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000004">
        <property type="entry name" value="Adenine phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050054">
        <property type="entry name" value="UPRTase/APRTase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002636">
        <property type="entry name" value="PRK02304.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315:SF3">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="12">
        <location>
            <begin position="36"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCF47661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WWC67553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="178" mass="19591" checksum="D95D41E21F69320C" modified="2016-11-02" version="1">MSDVTYLKNLLGVHPNFPKKGVTFLDIFPILRNPIAFETLITHLIHHILTNNEIKPDVIVGLDARGFLLGPIISMRLGCSFVPIRKGGKLPGLVEVVKYEKEYGIDEFEIQSDAIKPGQNVIVIDDLIATGGSAHAAGELIKKSGGKTLEYVFIVGLPFLKGHEKLDAKSYWIVEAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HX21</accession>
    <name>A0A1B9HX21_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SBDS family rRNA metabolism protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_05670</name>
        <name evidence="12" type="ORF">I206_107343</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDO1/SBDS family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894014">
        <property type="protein sequence ID" value="OCF47810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009029.1">
        <property type="nucleotide sequence ID" value="XM_019157389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HX21"/>
    <dbReference type="STRING" id="1296096.A0A1B9HX21"/>
    <dbReference type="GeneID" id="30174039"/>
    <dbReference type="KEGG" id="kpin:30174039"/>
    <dbReference type="OrthoDB" id="10253092at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.900">
        <property type="entry name" value="SBDS protein C-terminal domain, subdomain 1"/>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Roberts A."/>
                <person name="Saif S."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Abouelleil A."/>
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                <person name="Berlin A.M."/>
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                <person name="Dewar J."/>
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                <person name="Griggs A."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">CBS 10737</strain>
        </source>
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        <source>
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        <source>
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    </evidence>
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    </evidence>
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</entry>
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            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Abouelleil A."/>
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                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
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                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">CBS 10737</strain>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Pearson M."/>
                <person name="Priest M."/>
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                <person name="Saif S."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 10737</strain>
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    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
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                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Roberts A."/>
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                <person name="Sykes S."/>
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                <person name="Nusbaum C."/>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
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                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
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                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
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                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Chapman S.B."/>
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                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Murphy C."/>
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                <person name="Roberts A."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
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    <reference evidence="3" key="2">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
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                <person name="Gargeya S."/>
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                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
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                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
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                <person name="Imamovic A."/>
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                <person name="Nusbaum C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
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                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="30174511"/>
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    </feature>
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            <begin position="543"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF48274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC73837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="659" mass="74757" checksum="67981B862DD46CD6" modified="2016-11-02" version="1">MKIISPTPSSAMDQSALRPVQRKRSSRIAAVKAKARTSEQLLTENQLSFEKSISSDSSNSTDSPNDDGNDFPEVGQEDDESEMGSGKEDENDGLLFNELGEKWLKPKEPFPWDEVEWYLDESIGVEMIAHVSKRIEKMQGTITDDIEVTDIILINPHPSHLSSERSKYLRKLGHVKNRLCIILPYTYLSKCYFSKKVEKTDKRQPIFLNDKGLGMKVTVTKLGEGEEGINKRKAIMIDLESHGAMIVPSSNDADICIVPPSHPYLKSPPKNTKYDNIKWYTSEWVENQIKAFENEFQAKLKSKTMTENSKSQRSRLKPISEWKGGLKPLKMNRTKPPSFSGGLGRNKTHLEGSQFIKQRSGIRTEFTPSDRDFLARWLAYNKPDNVGRTTKSLYLELESFRPSSPWYHTANRHPPSAWHEHFKRNRSKLGMDGKILEDQVDKYVDRGVNHTLRTRRERSEVEDGDSNPKRTGLELNNQDQTQENEAGLVEGFEENHGKKVNATGVVRRQGNKSKKQKLDGQVRKARKITIDYPQFTDEIIADQEEDSDNAEIGEDDDTSKQGRNEDSQVNDVINAQVRELNHGDSTSDSLRVDEVLGESSEASDELRNYSHREEVELNDAPAESSNGIVQGEANNAAKEGQVIDPDATSPRRSKRIRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HYL4</accession>
    <name>A0A1B9HYL4_9TREE</name>
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        <recommendedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_05133</name>
        <name evidence="3" type="ORF">I206_107323</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1296096.A0A1B9HYL4"/>
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        <property type="evidence" value="ECO:0007669"/>
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    <dbReference type="InterPro" id="IPR052228">
        <property type="entry name" value="Sec_Metab_Biosynth_Oxidored"/>
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    <dbReference type="PANTHER" id="PTHR47534:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
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        <property type="match status" value="1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF48356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC73356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="31907" checksum="F50711E6F58A1EC9" modified="2016-11-02" version="1">MTPNPKVALQSTRISSGLTALVVGGTTGIGSAVARKLAAIGCSRVIILGRDEKRAGDVLDRMRDTATKGFEGSFIKGDISYVRGIKAALESLKSLLGNDKLDYVVMCQNGPPTGTVNINEDGEGKEFTIQAISRFLLTHLIINNELLNPNAKKVAENGRSKPLLTIDQSRRDSTVLDSVILEFNARYPQYTFYHLHPGLVKTELFDIHLFPFPLSYIAGLGLLMMGSTPDEYANIPVYILVHPDARKELGEGKFWDHRIKVKNPSVWPSARENREKLWNKLLAMTEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HYS5</accession>
    <name>A0A1B9HYS5_9TREE</name>
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        <recommendedName>
            <fullName evidence="10">Mitochondrial fusion and transport protein ugo1</fullName>
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    <gene>
        <name evidence="7" type="ORF">I206_05181</name>
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    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
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            <taxon>Tremellales</taxon>
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            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC73307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009623.1">
        <property type="nucleotide sequence ID" value="XM_019156905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HYS5"/>
    <dbReference type="STRING" id="1296096.A0A1B9HYS5"/>
    <dbReference type="GeneID" id="30173550"/>
    <dbReference type="KEGG" id="kpin:30173550"/>
    <dbReference type="OrthoDB" id="77989at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCF48404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC73307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="473" mass="52739" checksum="D72B041CFC744663" modified="2016-11-02" version="1">MTSSARPQSVRGLYTPPAEEWVFLPPSVSPPSTSSPSASAAPTHLPSSFNPNVEDEENLALPMMGRPFNLFLSEYLTTAMGMPFEVGKTLLQVEYRPRRKFVKEDELDIQSIEEKERFELQDDQISNPEEADMYFSDRLAQPAAPLLPPPELIAETDASGYLPDLHPSYLLNDDPEVSRGNGVWGMIRRIRYTPSEGLPGLWKSQILSTIHSFLSNLLQPTIHSCLLILIPNLEPGIGLDISLSALPNPGIPLTLQVSSHLISHLILSPLEIIKTRLIISPSNHSSNLNSISIFKQLIEKEGGFFNLYFHSNLLIPSILEHTLRPLLTLSIPLLIERQFNISPDISPITYSLMDLSLGLSSLLILLPIETVRKRLQLQNRGILTNGEKQKSIVKLREKNYIGVVEAIWRIVNEETGIRRKRKMTERDEGGWFSGVRQLYRGFGMAATAHVTVFGLGLVSQVLSGNDGGGWKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HZA1</accession>
    <name>A0A1B9HZA1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sorting nexin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I206_05337</name>
        <name evidence="16" type="ORF">I206_107119</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Prevacuolar compartment membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC73153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009777.1">
        <property type="nucleotide sequence ID" value="XM_019157059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HZA1"/>
    <dbReference type="STRING" id="1296096.A0A1B9HZA1"/>
    <dbReference type="GeneID" id="30173706"/>
    <dbReference type="KEGG" id="kpin:30173706"/>
    <dbReference type="OrthoDB" id="5227681at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034499">
        <property type="term" value="P:late endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07295">
        <property type="entry name" value="PX_Grd19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000030">
        <property type="entry name" value="Sorting nexin-3, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042138">
        <property type="entry name" value="PX_Grd19_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051074">
        <property type="entry name" value="Sorting_Nexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963">
        <property type="entry name" value="RE52028P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963:SF2">
        <property type="entry name" value="RE52028P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="14">
        <location>
            <begin position="153"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="36"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="80"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCF48558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="WWC73153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="275" mass="31644" checksum="93669F03AF94ED90" modified="2016-11-02" version="1">MNQSQPYDSNQYYQNSQPYQSLSNSQTFQSPNSQGYNSNQGYSSPPPQQQQNQYSSQGFQSPNVNFGQQQEWPQSPPPQQQQSGQGYQQNPQSAQQGYFGQGGYNQQPQSPPVEVTHSPFVRTDSSARLTFTDMARMAGRPQTFDEMYAVPESFLEIEIRNPMTHGIGRKMYTDYEIVCMTNIPAFKLRHSVVRRRYSDFEAFRDILERESTRVNIPPLPGKVFTNRFTDDIIEQRREGLQRFLEIVAGHPLLQTGSKVLCAFLQDPSWEKSQWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HZF1</accession>
    <name>A0A1B9HZF1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="10">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_05449</name>
        <name evidence="13" type="ORF">I206_107008</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="10"/>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC73043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009888.1">
        <property type="nucleotide sequence ID" value="XM_019157170.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A1B9HZF1"/>
    <dbReference type="STRING" id="1296096.A0A1B9HZF1"/>
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        <property type="component" value="Chromosome 10"/>
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        <property type="term" value="C:mitochondrial inner membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:holocytochrome-c synthase activity"/>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
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    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF3">
        <property type="entry name" value="HOLOCYTOCHROME-C SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
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            <begin position="20"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="74"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCF48669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC73043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HZK8</accession>
    <name>A0A1B9HZK8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dynein light chain roadblock-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_05504</name>
        <name evidence="5" type="ORF">I206_106954</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GAMAD family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC72990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009942.1">
        <property type="nucleotide sequence ID" value="XM_019157224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HZK8"/>
    <dbReference type="STRING" id="1296096.A0A1B9HZK8"/>
    <dbReference type="GeneID" id="30173873"/>
    <dbReference type="KEGG" id="kpin:30173873"/>
    <dbReference type="OrthoDB" id="9985637at2759"/>
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        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10779">
        <property type="entry name" value="DYNEIN LIGHT CHAIN ROADBLOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103196">
        <property type="entry name" value="Roadblock/LC7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Roadblock/LAMTOR2" evidence="3">
        <location>
            <begin position="30"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="50"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF48723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC72990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="146" mass="15808" checksum="8FE52312A5F965A5" modified="2016-11-02" version="1">MSTDQLPSSTSQHTLSLDSLPVQSPPPPEIESTLSRLSAYRNVKGVMILSRSSSSSSSSSSSKSNGQMDGENTGGIVQTNGNVFEGESGKKYAKAVEEIVEKVGKALSDCEDSDELKFMRIRTKKHELIITPDDKYLLVVLQDPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HZZ2</accession>
    <name>A0A1B9HZZ2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endoribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_05615</name>
        <name evidence="3" type="ORF">I206_106840</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC72876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010053.1">
        <property type="nucleotide sequence ID" value="XM_019157335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HZZ2"/>
    <dbReference type="STRING" id="1296096.A0A1B9HZZ2"/>
    <dbReference type="GeneID" id="30173984"/>
    <dbReference type="KEGG" id="kpin:30173984"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF42">
        <property type="entry name" value="MMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF48834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC72876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="129" mass="13990" checksum="AF7CC33C30F41234" modified="2016-11-02" version="1">MPAEYTLTKDAPAPLPGIYSQAVRAGNYVYTSGSVGMAKEGHMIEGTIQDRTKQVIQNLEAVLKGSNMTLKNVVKANIYLSNLSRDFNAVNEIWKELMPEPKPARTCIGVAELPAGGTDVEIEFVAYDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I067</accession>
    <name>A0A1B9I067_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_04620</name>
        <name evidence="13" type="ORF">I206_105800</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF48933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC71841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010152.1">
        <property type="nucleotide sequence ID" value="XM_019156350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I067"/>
    <dbReference type="STRING" id="1296096.A0A1B9I067"/>
    <dbReference type="GeneID" id="30172989"/>
    <dbReference type="KEGG" id="kpin:30172989"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05580">
        <property type="entry name" value="STKc_PKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF37">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="189"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="11">
        <location>
            <begin position="477"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="72"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="541"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCF48933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC71841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="562" mass="62891" checksum="74B10E11B5871A5B" modified="2016-11-02" version="1">MDIDPPLTTPSTSSSSSSTSVNSNTNKEKPKKFKLDPMSLLLPHERQAYLAPQQQSQQQPQARHPPAHPQGYINSSKVAQYNKPLSQSPIPSLQNQAGPSRLVGTQSSGGTSSNERPPQPYTQPQIPSQALPISPPASLISTPPPAQWDSLSIASTPYSLDGTSSVSSHYSHQPPYHPLRGSKVRLEDWEIVETLGTGTFGRVLLVRQRPSYRPTPYHPIFPHLFQSLDPLSPSPSSTQQSDNQLPHFAMKVLKKSEIVRLKQVEHINSERSILEKVRHPFVVELYATYQDQLNVYMLLSYIPGGELFSHLRRAGRFSADVTRFYLASIILAIEYLHSRDIIYRDLKPENLLLDRHGYLRIADFGFAKIIEDRTFTLCGTPEYLAPEIVLSQGHGKAVDWWALGILAFEMLAGYPPFFDDHPLGIYEKILRGDIAFPSHIDPYAKDLIRGLLTADRSKRLGNLRNGARDVMSHAWFAGVDWRTLERKEIGAPIVPRVASMGDSQNFQRYPPPRPHELPGIFGQPYDMTTDQYGELFKDFSFPPSAINSSSSDKASPVISEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I071</accession>
    <name>A0A1B9I071_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_04619</name>
        <name evidence="5" type="ORF">I206_105799</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
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    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
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            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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            <strain evidence="4">CBS 10737</strain>
        </source>
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            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Saif S."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="Dewar J."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF49017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC71925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="373" mass="40647" checksum="656C8D50E6BF675D" modified="2016-11-02" version="1">MSDTRAEAEKEIDTVEMSSNLEDSLGSALESSFNIPPPPPAPLKGSEKSHEPNAIPDETVKASQSETIEGMAEWKDTLENYTKEWQAESSIAREKALATRIRIEKENSDAEKKMKDDLAKEKKFKLDAEKKKRDEERLKAELESDDISSLKNKKQLKSNEKVKEAWELVGEKKDSKGTVETDGRGPSKEAKKDIKTLSYDPTKSTDPIPPVFQDPVPASQTSAPTESATLSRHSATSGAWEEVSRGSPGSGSSGEQVSRPQSNSEESDIVNIPSSSKGNDDKNQSQPPQQPPSLTLSLFDPSQLTFRRVLAVVGINLILPFVNGVFLGFGEIFAREVVRVGKLVWRGERTIWSFGRGAAAGRGTSGVGLSGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I0J4</accession>
    <name>A0A1B9I0J4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptide hydrolase</fullName>
            <ecNumber evidence="9">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_04753</name>
        <name evidence="12" type="ORF">I206_105930</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M28 family. M28E subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="9"/>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC71971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010285.1">
        <property type="nucleotide sequence ID" value="XM_019156483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I0J4"/>
    <dbReference type="STRING" id="1296096.A0A1B9I0J4"/>
    <dbReference type="GeneID" id="30173122"/>
    <dbReference type="KEGG" id="kpin:30173122"/>
    <dbReference type="OrthoDB" id="2214at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03879">
        <property type="entry name" value="M28_AAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000042">
        <property type="entry name" value="Peptide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF56">
        <property type="entry name" value="AMINOPEPTIDASE YDR415C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008448409" description="Peptide hydrolase" evidence="9">
        <location>
            <begin position="17"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="10">
        <location>
            <begin position="176"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCF49066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC71971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="391" mass="42953" checksum="890DCBE6CA3C49DE" modified="2016-11-02" version="1">MLLKAALLALPLLVSAIPTQPEQLTFNNHGSTDVAGYSLDLNDLRLVQFSEEEPPVWISELEKIEAKSKGRKFMDITETPTLGFSSYLLPSTANARYTYPSPGNYSKPIKSIIKSLDIKHMKSFLKEFTSFRTRYYRSETGKQSQQFLLSKLKEISSAHPGVTIKEFPHSWGQNSIIARFEPSSSMKGDAPVVIVGAHQDSANQWPFLPAPGADDDGSGTTSSLEAFRALAHANFTPSHPVEFHYYSAEEGGLLGSQAVAKAYEDKGLKVLAMIQMDMTAWVKAGTKESVGVIQDYVDPELTKFVGKLVDEYLAIPAVETKCGYACSDHASFAKAGYQSAFAIESTFEDSNHNIHTSGDTTNHPEFSFTHMREFSKLALAFAIELAGINEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I1B4</accession>
    <name>A0A1B9I1B4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_05005</name>
        <name evidence="10" type="ORF">I206_106180</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010533.1">
        <property type="nucleotide sequence ID" value="XM_019156731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I1B4"/>
    <dbReference type="STRING" id="1296096.A0A1B9I1B4"/>
    <dbReference type="GeneID" id="30173374"/>
    <dbReference type="KEGG" id="kpin:30173374"/>
    <dbReference type="OrthoDB" id="1368at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF19">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION CHANNEL-FORMING PROTEIN YNEE"/>
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                <person name="Chen Y."/>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="Mohammad A.W."/>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
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                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
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            <dbReference type="Pfam" id="PF23647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF49546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC70404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="724" mass="81137" checksum="12DB94ECFF68294F" modified="2016-11-02" version="1">MEPPLTLIINQISPPNLIPGYIPSSSPPVPFSAAPTLPPPPSSFTLSPTANYPSPFGIISLGSTLSLELSLENTNYSQNDILGVKMMIECQGSNGRFRLGEIIHQNEKSNHEFENPFIEEDKQEINLSKEEEIKEDKIENLSILKFGEKVNIKIENEIKDLGLNILIISVAWETLEGRKTFQRFLKFNVNPPLSIKTRIQIPSSPNILLSSSQRDKIYLEILLQNISSEFMILNEIYLEPIKGLNSISLNDIEQENIILLPEDIRQFLFVLSPSIEDIGNINQSKFPPSYSGGTILPLGRLDINWKSGQYSLPGRLQTSTLNRRIPPSSSPAVPPKGGILPTRTLSSQSNVGSVGVPGSPLAQTRDRLNNNLLAPSPIKGSLPSSTVESESQGNEWEFDLTLKEDEQEVMREFEVEQRFKMNFKLGMRSTKSFETMQTIPNHKAGDDDNEDDQPLSRISSRVSQSNSYDPMPPKIPKIAVQYLTPLANSSTQSQVGNKPQLNILSPSRTNTPMSPTPSNNNDKRPFSPFNSRSGTPSNNIPNQLKLAQTQGLTSITNLSGIGNSTPKFNNIPLIVNNEDVLIIEGEKEEGFPPLPFIKSNNNCEIINLGNSLQFLKFNDNDNNNNKFKKVKENFHPTYSTNDNEDNNNNKLKKEIYKWEIEFEFNLEFIAFDQGFFELGGLRILIFNKNDNDDDNDEDNDDNNNEIKGKILKEWKSLGNLHIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I2G7</accession>
    <name>A0A1B9I2G7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_04238</name>
        <name evidence="3" type="ORF">I206_104187</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010933.1">
        <property type="nucleotide sequence ID" value="XM_019155975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I2G7"/>
    <dbReference type="GeneID" id="30172607"/>
    <dbReference type="KEGG" id="kpin:30172607"/>
    <dbReference type="OrthoDB" id="2596179at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF49714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC70237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="207" mass="23989" checksum="DE4F5C604561C9DC" modified="2016-11-02" version="1">MIRLGPRQLLRRSTLPSNQHRPVPPHQQFRTNFVQSFNEFKPPPIRQRLKPLIPFFIYWSIITSLAVHLLRNRINSKEELDKQKAKITVLSDIIKRLQNGETLNEDQIQRELELVGLRERTILTQGVQLEEDVKNVGWSEVLFGKKRIKDEETKEINEESLDDWVQVVNEVTKPATSPIMLPTSSITPKSPERSGETKRAPSSSVYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I317</accession>
    <name>A0A1B9I317_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sarcosine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_04467</name>
        <name evidence="9" type="ORF">I206_103960</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011155.1">
        <property type="nucleotide sequence ID" value="XM_019156197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I317"/>
    <dbReference type="STRING" id="1296096.A0A1B9I317"/>
    <dbReference type="GeneID" id="30172836"/>
    <dbReference type="KEGG" id="kpin:30172836"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050031">
        <property type="term" value="F:L-pipecolate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF46">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="8"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF49936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC70016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="461" mass="49848" checksum="99DF8D0321BF8C21" modified="2016-11-02" version="1">MSQSKTNVVIVGAGIYGMSTALWMLKSGKYNVTILDKCGILPAPDAASTDLNKIIRSADYADASLAALGLEAIDDHWRKPEWENTYHESGVMCLSGAGEKAGQEFVSKAYSNCKNLGINVTLINGSTDIKNIIKKKVAQGVPLGEFGGREGYFNPIGGWAESGRALEVGLKKVRQLGGTVRSGAEVQSLLRNGRKVIGVEIKGGEQVKGDLVIVAAGAWTPALCAQPGFSVRLPDVVATGQSVGVIQLTPEEHKKYADIPVVFNLDNGWYNFPPNAEGLMKLAIHGAGVLCPGENGVSVPRTKLTPGGESGAIPLDSLRGLREGLREVYPELAKKDFLTTRLCWYCDTITGDWLIDYHPDYDNLVIASGDSGHAFKFTPVIGREILKVVEKNPSPEYSEKWSFNYVENLLKRESKKQISDVDVENPELAKGGADVRAGQRKVLDVNDLVKPQDLLAKQARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I328</accession>
    <name>A0A1B9I328_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CTLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_04436</name>
        <name evidence="4" type="ORF">I206_103990</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011124.1">
        <property type="nucleotide sequence ID" value="XM_019156166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I328"/>
    <dbReference type="STRING" id="1296096.A0A1B9I328"/>
    <dbReference type="GeneID" id="30172805"/>
    <dbReference type="KEGG" id="kpin:30172805"/>
    <dbReference type="OrthoDB" id="8048523at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTLH" evidence="2">
        <location>
            <begin position="105"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF49905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC70046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="367" mass="39914" checksum="2F49748A24D6AE36" modified="2016-11-02" version="1">MNGSSSSSSSFQNINSLHDVILNYVETSGYASTARILAKTQLTHESPSNGTTNNGNGGEEDNMDIDEDDIKVEDGLGNEGKRLSDKKGKGVMKGGLSFSERDLEDIENRRVILNHILNGSISKSVDLLKTYFPSVLDDSLEIKSSTINGFESNYINPKYPSNHSIPVLIKSTIPSHVKLNLQIQQFIESLRQLNPSSSSSSIPSSPSSSIGSLGNSGTLSSSSIGLTHTLSAAQGLHSEAKKLSPDIRAIYLQEIQDVGALLAYADPENGPLKGFLSQDRRIRLSEMVNSAILKSQGKYTESALEAYSRRTTVLYKMMSEFGLDPKSNWTTVSGESGNGKDEAHLAEYWKQANGKPFSLHNFVNSTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I353</accession>
    <name>A0A1B9I353_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">V-type proton ATPase subunit E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_04511</name>
        <name evidence="11" type="ORF">I206_103916</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the V-ATPase e1/e2 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC69972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011199.1">
        <property type="nucleotide sequence ID" value="XM_019156241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I353"/>
    <dbReference type="STRING" id="1296096.A0A1B9I353"/>
    <dbReference type="GeneID" id="30172880"/>
    <dbReference type="KEGG" id="kpin:30172880"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008389">
        <property type="entry name" value="ATPase_V0-cplx_e1/e2_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12263:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12263">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05493">
        <property type="entry name" value="ATP_synt_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF49980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC69972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="71" mass="8037" checksum="4D834CCA92E30C1F" modified="2016-11-02" version="1">MSFFHIVIVAAVVAAIAAVAWFVMPKGKNQTLLRTAVLLTLTCCYLMWAITYLAQLHPLIKPRRSDLRSEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I372</accession>
    <name>A0A1B9I372_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_04523</name>
        <name evidence="8" type="ORF">I206_103904</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
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                <person name="Goldberg J."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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                <person name="Birren B."/>
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                <person name="David-Palma M."/>
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                <person name="Mohammad A.W."/>
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                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="David-Palma M."/>
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                <person name="Bowers K."/>
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                <person name="Mohammad A.W."/>
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                <person name="Cuomo C.A."/>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011368.1">
        <property type="nucleotide sequence ID" value="XM_019155214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I3P0"/>
    <dbReference type="STRING" id="1296096.A0A1B9I3P0"/>
    <dbReference type="GeneID" id="30171837"/>
    <dbReference type="KEGG" id="kpin:30171837"/>
    <dbReference type="OrthoDB" id="10044044at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd12108">
        <property type="entry name" value="Hr-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053206">
        <property type="entry name" value="Dimeric_xanthone_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048:SF1">
        <property type="entry name" value="HEMERYTHRIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin-like" evidence="1">
        <location>
            <begin position="13"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF50149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC71674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="165" mass="19712" checksum="238C5F41E2E009C0" modified="2016-11-02" version="1">MPSKEDREWNRMADHMDQFHNHFRYEFNRVYTLADGGFRKEGLSLPRFIREAQQLYSHLDMHHRIETYIFPVLAKKMPQFKAGARESGEHLRSHKAIHDGLDKYDKFLREALDGSSEYNAAKLREIMDGFREVLFRHLDEEVHDLGMESMKKAGWTLDEIRRMPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I3V1</accession>
    <name>A0A1B9I3V1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">6-phosphogluconolactonase</fullName>
            <shortName evidence="6">6PGL</shortName>
            <ecNumber evidence="4 6">3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_03516</name>
        <name evidence="9" type="ORF">I206_105581</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="4 6"/>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011416.1">
        <property type="nucleotide sequence ID" value="XM_019155262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I3V1"/>
    <dbReference type="STRING" id="1296096.A0A1B9I3V1"/>
    <dbReference type="GeneID" id="30171885"/>
    <dbReference type="KEGG" id="kpin:30171885"/>
    <dbReference type="OrthoDB" id="432544at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000005">
        <property type="entry name" value="6-phosphogluconolactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="6PGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054:SF0">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="7">
        <location>
            <begin position="16"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF50197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC71623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="308" mass="34402" checksum="0A2D1FDC7F12986E" modified="2016-11-02" version="1">MPQSSAPPVLYSYENVDKLTSSLANFILKAQTDAISHRGVFTIALSGGSLPNNLKPLVDVKEIQWDKWQVFFADERIVPLDHPESNYSACSKAFLDLVPIKKEQIHTINTELFREQTRIDPTAEIKSGEEDDAENEAVEIADDYEKQLVNTFAGANAARYPTFDLILLGMGPDGHTCSLFPGHELLSENDRWVAEIQDSPKPPSRRITFTYPVLNHAFRCAFVAVGEGKQEMLSSILDKPEEGLPCSRVRPISPGLVFWFVDNAAAAGVKYPKTEYKWIEKATDDDLITGERKRLKEEMDAAVEAADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I435</accession>
    <name>A0A1B9I435_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MHYT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_03604</name>
        <name evidence="5" type="ORF">I206_105493</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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            <strain evidence="3">CBS 10737</strain>
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    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
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                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
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                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Sun S."/>
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                <person name="Young S.K."/>
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                <person name="Gargeya S."/>
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                <person name="Berlin A.M."/>
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                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Gargeya S."/>
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                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
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                <person name="Saif S."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">CBS 10737</strain>
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    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011551.1">
        <property type="nucleotide sequence ID" value="XM_019155397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I484"/>
    <dbReference type="STRING" id="1296096.A0A1B9I484"/>
    <dbReference type="GeneID" id="30172020"/>
    <dbReference type="KEGG" id="kpin:30172020"/>
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    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
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        <property type="term" value="C:exomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:Golgi to plasma membrane transport"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="Clathrin-coated vesiclec protein (Bud7)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Clathrin-coated vesiclec protein (Bud7)"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015374">
        <property type="entry name" value="ChAPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31975">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31975:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09295">
        <property type="entry name" value="ChAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="241"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="447"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="447"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="475"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="492"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF50332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC71485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="720" mass="80616" checksum="2A5FE4B0CA2718CE" modified="2016-11-02" version="1">MSELFKDLPEFVESNIGESVTARTETLATFRELGPPDLCHVIKSSGSKTAQKDLGSYHYCSGVEASSSASLAAYLNSLQFSVEEDTAWFGKGNGWRVRSGTYCCFNAFSRVDMRVDVKIPGGVDAYVVDLRGDKHAATPDLWQETYLSALLRAIRYADDASYRLAGYRKLDPITTPEAEGRFLKAAEALFFKGWQLGSDPEIQVATVVTNHLTSAVIKYFADSFRLDRAANLFERMMVNEPEVAALLAKSYIGMNEEIKAVKIMHSALSLNPQSYPILHTQCDFLLSKGKPEWAQQIAQQAVNSAPSEFVTWAKLTETYIELGQFDQALLTLNSCPMFTFNERDLHRMPTPLKTHLPVKKFIGESGILDEESARDNEADVALIRLPAPGLRGTFAKAYSLLTLLVSKIGWDELLKTRSQVFVMEEEYRLHKTSASVELNGFAHENASTTGIRSSNSNGGGDSVPNTAISDIPTIRISTESTRTPNGTQLQHQKKESVQMDTVLEKPEIAQINDDEPNSPIGIKADDPSVNSSEGDVVDGDEGDNAPSAFANKRLCERWLDNLFLVLYEDLRVYTIWRAEISHFKTQHMSYRKTGTEWEILGELALRLHHKEEAKDAFQRCLDSKFSAKALIKLLEMYATEGDLQRTLNSAIRLTTYHHRWYMDTAYPSMIAHYLFKLGLIHGHAKIQYTLLSMNLPVGIFEIMQGYMKYGATFNVEGSEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I4E4</accession>
    <name>A0A1B9I4E4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BolA protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_03700</name>
        <name evidence="3" type="ORF">I206_105393</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BolA/IbaG family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011598.1">
        <property type="nucleotide sequence ID" value="XM_019155444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I4E4"/>
    <dbReference type="STRING" id="1296096.A0A1B9I4E4"/>
    <dbReference type="GeneID" id="30172069"/>
    <dbReference type="KEGG" id="kpin:30172069"/>
    <dbReference type="OrthoDB" id="4983at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045115">
        <property type="entry name" value="BOL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12735:SF27">
        <property type="entry name" value="BOLA-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12735">
        <property type="entry name" value="BOLA-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003113">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF50379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC71437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="93" mass="10674" checksum="ED7A9B0A3000F285" modified="2016-11-02" version="1">MEIDEQSESQTILQSMETKLRSNLKIEFLEFIDTSGNCGSSYSVTIVSSDFNKKITLARHKLVNQILSHEISQLHAFSQKTLTPEQWLKEKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I4L8</accession>
    <name>A0A1B9I4L8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_03785</name>
        <name evidence="3" type="ORF">I206_105305</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
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                <person name="Gnirke A."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
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    </reference>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC71340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000094020">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nascent polypeptide-associated complex subunit alpha-like UBA" evidence="1">
        <location>
            <begin position="71"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF50473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC71340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="126" mass="13496" checksum="80374C4010782894" modified="2016-11-02" version="1">MAASSSSGRIPQGEVIMDFADGGQYIKHKLENAVLEIERRKITKEEGIKAQKAMEALDVKPNGTTGVSNGVKSEDVDFIVSQVGCTKEEATEALKAEKGDLVKALIKSVQPRPRARSVDGGAEVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I4P0</accession>
    <name>A0A1B9I4P0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BRO domain-containing protein 1</fullName>
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    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_03796</name>
        <name evidence="10" type="ORF">I206_105295</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome</location>
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    </comment>
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        <property type="protein sequence ID" value="OCF50472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1296096.A0A1B9I4P0"/>
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    <dbReference type="KEGG" id="kpin:30172165"/>
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    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
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    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09242">
        <property type="entry name" value="BRO1_ScBro1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF30">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="6"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="751"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="796"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="459"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="585"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="751"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="813"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="846"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="864"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="896"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="907"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="944"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="993"/>
            <end position="1010"/>
        </location>
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            <begin position="1011"/>
            <end position="1025"/>
        </location>
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            <begin position="1032"/>
            <end position="1048"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00041284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF50472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC71341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1048" mass="115487" checksum="55E27B99D3515621" modified="2016-11-02" version="1">MAFQSPLISIPRKTTQDVDWTNPIRSIIAQSYGEDPKNYVEECSNLQRCRQDAVRGAGSDQTARDLLYKYFGQLELLELRFAEIKVPFIWNDAFTDKPTTQTSLAFEKASIIHLISSVLSALAQTPSRSDPEGLKRAYYNTRASAGMLTYINENFLHAPSTDLSREVVQLCIGIMTAQATEIFTEKLIEEKKSAALISRSANSTAGMYSTALEEMKEFQGKGIFDRNWLYVLQIKSKLFASLTQYYKGVSDNAGGKHGISLVRFRLADTLAKEASQQAQSFNYGFVASSTPSLPHDAATSLMEITKSHQTICQEIKDQSVKDNDLIYHEVLPSEAALPAIEKLPATNPITIQEIYGNPEITKLIGPDIFIKLIPLAVHESASIYSEEKAKLVRNEVERVELSQGELNAGLDHLGLPSVVNQWRNILDDESSNNNDVDISSQVRRLAEDISRGGSIETSLRQLDGERERCERELRELSGLLDNASRECERMRAKYTPQFTQSPSGPQTANLRSNIAANLSALSSAGQSDSHLNTIWREIQPQIRLLSSGESQLENAAAQVAIGKATAPVNQGISLLDLQEDVVLKSGLAEAEKEELQKAISEASERLDRLGKISRERDEVLKDLKEKVQNDDVSNLLLLNRRSTGVEPQLFAAELEKFRPYQSRLAAAIQASSSILTELEMLVRQVEKGKGVKELQRSNKDRSKRVREWERKLIEAGEGWAEIQAGLSKGLTYYDSLNSALEELRREVTSFVRSRESERNRLVGEIETRQRIGGSPPPSSNVGGARSLEERLAALSVDRSSSGYSQPSQKPSTPSFPPPPPQVSTPSAFPPPPPAKPTNPYDFSNLSSIPSAFSTATSPSPPPTQSHASYGSSSYAYKPPQQASPYPAPPQQQSNPYPAPLSQPPRPAQTSYGSYGSSSQASYSSSPHQSSYQTPPAHQQYSSAPPQPPSQPSYPSQPPPPSQARYPSHPPSNQASYPSYAPPATQAQPQHGYYPPPPSQRPAYSSPPPQQPQQQYPNYPPANGQYQPPPPQQGGQYPGYQPQGGYQYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I509</accession>
    <name>A0A1B9I509_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_03938</name>
        <name evidence="7" type="ORF">I206_105152</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011832.1">
        <property type="nucleotide sequence ID" value="XM_019155678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I509"/>
    <dbReference type="STRING" id="1296096.A0A1B9I509"/>
    <dbReference type="GeneID" id="30172307"/>
    <dbReference type="KEGG" id="kpin:30172307"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628335" description="FAD/NAD(P)-binding domain-containing protein" evidence="5">
        <location>
            <begin position="20"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCF50613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC71199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="574" mass="65504" checksum="C14835470C0424FB" modified="2016-11-02" version="1">MLGWMMTTLVVGMTAQVAATPFGKQSPFLQSESTSEKQWHSFQQEIKKVAVIGAGPSGLQSAAALIKEGFEVRLIERSDAPGGNWYHNVLTPIRERYPNDDVQTASYRPDPRANSVEYYQEGDEGLTLVDRWIDHIRPSPIWDDLETNSAPVFTTLPGVEYPTDAAWALQAQLVQRHVRTYASTHGLNANDRPWNASAPQILYYSTRVEQLKKQGHTWKLSLKKLTRLPDSDKVKAEWWEEDFDAVVIATGGYQAAHVPDITGLVEWSKVRRSNGHHPVKHSQHYRNPELYKNKTVVIIGASVSASEISRRIGPHVEKLYISLRNTTRNTYMARRSIRRLYSDAEHIPEIVEFGTLPSNESIKEGSVRLANGTLIGGIDEVILATGFRRSLPFLKDYYSIGGKVEPHSEKSPILTDAHNLQSLSWTGHYISDPTLAFTTVRAWTFGRYQSLAFAKVWKRTARLPSRERLWDEYFNDNHWQAPAKVVFGSIEEETLGRQYVAWLNSESLIHGGRLVDQWPIQNREKFAYYSDEAWEHGYTSSDNFTRFENTPRSEWPTYRRAVEATYELDSGSEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I568</accession>
    <name>A0A1B9I568_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-arabinitol 2-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_02711</name>
        <name evidence="5" type="ORF">I206_102364</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF50656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011875.1">
        <property type="nucleotide sequence ID" value="XM_019154472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I568"/>
    <dbReference type="STRING" id="1296096.A0A1B9I568"/>
    <dbReference type="GeneID" id="30171080"/>
    <dbReference type="KEGG" id="kpin:30171080"/>
    <dbReference type="OrthoDB" id="5325318at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044281">
        <property type="term" value="P:small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF14">
        <property type="entry name" value="DEHYDROGENASE ARBD, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF50656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC68436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="357" mass="38844" checksum="287FE3C44F9CE8F7" modified="2016-11-02" version="1">MSFLRSAINVSRVAPRRSPLAARVIPSVRSFTTPTVVRYDKNGDPLEEHRVEVEPSHATIDESITFEHPTKWSDKHPGHDMTKGDYGRHTKRTLSSFSMDGKVCLVTGAARGLGNMMARTFVESGANAIVLVDLKQDEAQKAADDLVKWFVENGEAEEGEIQALGLGCDVSDEASVAKVFATVKEKFGRLDACVTAAGIVENFVAHEYPTQKIRKLLDINIMGTWFCALEAAKLMPEGGSITLVGSMSGSIVNVPQPQTPYNFSKAGVRHMARSLAVEWASKNIRVNCLAPGYTLTNLTKVILDANPVLRDEWLNRIPMGRLADPSDLKGAVIYLASDSSKYTTGAEIVVDGGYTCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I5L3</accession>
    <name>A0A1B9I5L3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_02873</name>
        <name evidence="8" type="ORF">I206_102522</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF50816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012035.1">
        <property type="nucleotide sequence ID" value="XM_019154632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I5L3"/>
    <dbReference type="STRING" id="1296096.A0A1B9I5L3"/>
    <dbReference type="GeneID" id="30171242"/>
    <dbReference type="KEGG" id="kpin:30171242"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1350">
        <property type="entry name" value="Pneumovirus matrix protein 2 (M2), zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045072">
        <property type="entry name" value="MKRN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11224:SF10">
        <property type="entry name" value="IP09428P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11224">
        <property type="entry name" value="MAKORIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="216"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="427"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="343"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="389"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="480"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="560"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="579"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="596"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="657"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCF50816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC68592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="707" mass="73973" checksum="8B9ECC2050FAC484" modified="2016-11-02" version="1">MSVPLPSPSPLDSPSKSSNGNIGSNAKPIPKSRPSPITTNTPHSPSSPNFTASSSVNRGRSGLSSSISRSMLNDDNWRDRSPATVTATATAIGTPSTAIINGKIGNGSTKGPERTVGGFEKKEIKSTSTVSGLSANKDKKDNKDKKAGLEDQAESDKAALSHVPCRFFKAGACTAGDSCPFSHAAPDAAKREVCQWFLKGNCKFGHKCALAHVRPGEPMSMDRKNKKAAQLEARERGDSVSASAPPPAPSSGAGTGNTSGLGESPRPLGITRGRKNSTSPGEDQIASPVPIKSALSSSMQSPQAGRLPSSPLREPFGPPSGALPNSPNSAGFAQPRGIQGFASSPSRPSPLSGSFGASGSVPGPLSLRASASNPLGSPLRPPVTTAPGFSSSFSHPSLSLDRHGHSAAPSVPLSASFAGDANLHKSIWARSDTPEEPLSPRRRPIPRPTKSNQDAVFIDDEDHGEDFLPSSLSDLLTPQERARRMSRRDSQGQEDFAQSPSGRYGSPLWNQGFASGGERLAQSAGPALGPGVGGFLNSLWSADGEDARKSQNPDEFEVESPNTHTNQESQNGFAFGPTTAKQPPKRQTSLLTQQRSPTSGSSSITSPTSPNRQIHMTEPYLIRNLDSSSPSATKVLESHLPGQSLPGGLASALSRLHMQNSNNSKNQHSGLSIVNGQNNEEETNLQVIAKKGHTEEDEDDGLFDMDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I640</accession>
    <name>A0A1B9I640_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_03052</name>
        <name evidence="9" type="ORF">I206_102699</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF50990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012209.1">
        <property type="nucleotide sequence ID" value="XM_019154806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I640"/>
    <dbReference type="STRING" id="1296096.A0A1B9I640"/>
    <dbReference type="GeneID" id="30171421"/>
    <dbReference type="KEGG" id="kpin:30171421"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12169">
        <property type="entry name" value="PGDH_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050857">
        <property type="entry name" value="D-2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="6">
        <location>
            <begin position="27"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="7">
        <location>
            <begin position="126"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF50990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC68765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="38753" checksum="4639E906B33604C0" modified="2016-11-02" version="1">MYASIKIAVLDDYNNLSPEYTSNLPSNLDITVYNDTILPVPDPQPLIDRLKPYEILVTMRERTPLPAKIIDSLPNLKLILTTGLRNRGIDIAAAKKRGIQVAGTPGPKTPPGLPPNFTATTQHTIALILSLVSNIPRDHTIISSNPTPEWIHYLPLNTFLGGLTLGILGLGKLGIGTARIASLAFGMKIIAWSPNLNQERADQSAIEANLPKGTFKVVSKEDLFKISDVISLHIVLSESTKDIVKKNDLDLMKSNSFIVNTSRGPLINENDLLSILEKGKIRGAALDVFDIEPLPADSKWRTTDWGKNGKSQVVLTPHTGYSYEDSLKAMWEGTKENLERIAQGNAVKWVIEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I6C7</accession>
    <name>A0A1B9I6C7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_03140</name>
        <name evidence="9" type="ORF">I206_102785</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COA8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF51074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012293.1">
        <property type="nucleotide sequence ID" value="XM_019154890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I6C7"/>
    <dbReference type="GeneID" id="30171509"/>
    <dbReference type="KEGG" id="kpin:30171509"/>
    <dbReference type="OrthoDB" id="6246201at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097193">
        <property type="term" value="P:intrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018796">
        <property type="entry name" value="COA8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31107">
        <property type="entry name" value="APOPTOGENIC PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31107:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10231">
        <property type="entry name" value="COA8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="23"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF51074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC68849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="203" mass="23275" checksum="D527DAC40F07A3D2" modified="2016-11-02" version="1">MIRCTTRPGTLSSVNRLSRIAFASTSAEASSSTSSPSTPRRRRSNANVPTSGVDLVAPPDPASNIRPIIYASKPSINPSTNSPYSASEFPTGSSDAKLENMELEWRLRRERVDLMNHRFWATTNLTFEAQKAHRLSLLPPASDPPTEEDERRREEALTQFYADWQIANQEKQIRWVKEWWREVWDGIKIQGKIYFLRALRRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I708</accession>
    <name>A0A1B9I708_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Agmatinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_03346</name>
        <name evidence="8" type="ORF">I206_102993</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF51279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC69057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012498.1">
        <property type="nucleotide sequence ID" value="XM_019155095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I708"/>
    <dbReference type="STRING" id="1296096.A0A1B9I708"/>
    <dbReference type="GeneID" id="30171715"/>
    <dbReference type="KEGG" id="kpin:30171715"/>
    <dbReference type="OrthoDB" id="288726at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via agmatine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11592">
        <property type="entry name" value="Agmatinase_PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005925">
        <property type="entry name" value="Agmatinase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01230">
        <property type="entry name" value="agmatinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="ARGINASE/AGMATINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF26">
        <property type="entry name" value="GUANIDINO ACID HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628464" evidence="6">
        <location>
            <begin position="17"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCF51279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC69057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="404" mass="44278" checksum="439A6AD44F0FDAFF" modified="2016-11-02" version="1">MFRLSILVGLLPLLAAATPAQQPLRHTYSEYLSGSDEPRHPPADNKHSSRPPAYGYEDPINVEFYANGDRGKPAPWPPYNTEEAYWGLKTFAHTQPVRCMTVDNSTLYDIAILGAPFDTATSWRPGARFGPGGIRNGAQRLGGANRLLGNNPFLDYTVVDCGDSRMTFYSNDLALATLEADYRSLINRSIATSFRKDEASLALDGQHHPRVVMLGGDHTIVLPALRALNEVYGPVSVIHFDSHCDSRHPDKGTLTHGDYFYFAWKEGLMSETNIHAGIRSNCDMPSDIETNFSTILADEIEDIGWQGVVSRLKARVGDSPVYLTIDIDTLDPAFAPATGTPEIGGWTTREMIKILHGLKDLKIVGADVVEVAPAYDDQAETTQIAAAGLVFELISMMTLTPVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I781</accession>
    <name>A0A1B9I781_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_02111</name>
        <name evidence="10" type="ORF">I206_104576</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012616.1">
        <property type="nucleotide sequence ID" value="XM_019153876.1"/>
    </dbReference>
    <dbReference type="STRING" id="1296096.A0A1B9I781"/>
    <dbReference type="GeneID" id="30170480"/>
    <dbReference type="KEGG" id="kpin:30170480"/>
    <dbReference type="OrthoDB" id="27962at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058565">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058567">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058568">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058564">
        <property type="entry name" value="TPR_TRAPPC9_Trs120"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013935">
        <property type="entry name" value="Trs120_TRAPPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058563">
        <property type="entry name" value="Trs120_TRAPPC9_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512:SF5">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26254">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26280">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26282">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26283">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26251">
        <property type="entry name" value="TPR_TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08626">
        <property type="entry name" value="TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trs120/TRAPPC9 N-terminal" evidence="4">
        <location>
            <begin position="196"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 TPR region" evidence="5">
        <location>
            <begin position="560"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 first Ig-like" evidence="6">
        <location>
            <begin position="878"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 third Ig-like" evidence="7">
        <location>
            <begin position="1269"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 fourth Ig-like" evidence="8">
        <location>
            <begin position="1424"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="150"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="296"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="693"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="296"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="345"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="389"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="706"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF26251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF26254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF26282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF26283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCF51397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC70625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1568" mass="173091" checksum="1A6436D93C23370B" modified="2016-11-02" version="1">MNSPTPLSPLTDPAALSKIPILLIPVHQPSSPVPSNIYNSYQNLIKRYQTLRGDEISRPAQSRSRQTSSSYELPPNPRLRFFPQSTGSSISVSKASTTNHVHLTYTGQAPAKHTYPLSLLRLSGFPLIVLGIAVEMEEQEEDGPGYAVDQEGGDISENISTPSAPTFQDKFLPNDNPEKSFDETISSIFPSTSPFPLVKRLLVVPNQSPRSPSSPRKQSQNPSHIKKDKGYMRFAPIDGADHWVGRVLGEVVGELLGELGEIATALETPAGMRTLSSTLLPSLTSTMPHPELNNIIASNRSTTPSDYPSRPSTSTPTGIRNSQSMDHMSGMGISLTRALTPGGRPTSIQPPSLPPIQTSSISPSPQPQPAASSNPFRRSTALASPFTRTSSATSATSSSSALPQISSTKYTNATLTGVAGGRLMKLLGDMYLLAGLYADAIKCYDDGAERCRAVGDVLWEGLTREGRAVAGIGEAWEGRDGSNLAQPFPTSPIPVEILSHYLSALACISRSPLPYPPTILSPSPQAVSGSISFPAPSTSNPSSVGTGEGLLSYLHTSLSLKVSHFVLLIWAAGGWGSIALSSLMTHTLPRSFVQPLQSHEKSDHTLRRRRHRSLALLSSSSQITRQSIFAYAEVALQPLHRAMTRTEQLTIHNECIWLSRWLDIPRKEITITREVIKRLAILVVEGREESRKVNSVGFPSRARSPLPTSSGSNLAAENRSDEAAAVGLGLGLSVPNQTVAVMRKESTEGNSGIISLLERVAEIMGVDLLSFSPSDISTGKTNRRSSLDLHEEFKGEGRFGWPELQVEFLKEGIAVMESLPEHPTIIRLCLSALSGLNGYLNPQSQHTLNKLYPGSLATTRRRGIDIGQLPWWIDDKIVLSVEIASLPSNKLPIQHSINEIAAQEGKKDPFLYNPRLRAAEAGKTVLVANEQVDIFVTVRNPFAFDLEVQDLSILTSGAPFITSPLPLTLPANSVQTVRVTGQSPIPGEMSIKGVSIRLIDGSSTEILMPVFDGKQKDKHDKRRSKLLYDSHKIKRSGLDARYTSLEKSKSQFGHIEEEGKWLECKVVPELPLAWIKKTSLTHGTVMLYNGETSTVKITLENSSSTPIDFIKLTFDDSTSREAQAIISEGELTAEQAYEIEYDQLNRPVFIWSRDEKEDVVIPPGGRINLDVQVLGKVGCTDGTIRIDYGYLNRSTSQQDNVESSSDNTFYTRQITFPVLFTVYHTIESHSLDLTRLTTVSSHLPNGMNDGYDKLENGNGHKTRPTLIRISSTSQAEDQLKKVLQDENDDDHCLLSLSVRNVYGVPFEITLQRQADADDTVTCTRLIPPEATERMILPLPRRMIPQELLVRPIPSLAERQYIVDKEKKSPFQLKKDRELFWYREELLALIKATWMEPGSMRRGTLNLRDQYFGPDLLDIFKSDEIQIHLSLDSDDKNKVNVMDFVNLNVEVTNKFEYPFRPFIHISPLPTSHSDNSWTQTQSTIQRNSLQFPTNNDNNSISKNILFDGLSSTILPLLQNNEKYTYTLGMTFLSLGKFGIRVAVQQVESDFDDEKDQKIWFSEILDVLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I7K3</accession>
    <name>A0A1B9I7K3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Borealin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_02160</name>
        <name evidence="13" type="ORF">I206_104625</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the borealin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012665.1">
        <property type="nucleotide sequence ID" value="XM_019153925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I7K3"/>
    <dbReference type="GeneID" id="30170529"/>
    <dbReference type="KEGG" id="kpin:30170529"/>
    <dbReference type="OrthoDB" id="2392550at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018851">
        <property type="entry name" value="Borealin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018867">
        <property type="entry name" value="Cell_div_borealin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16040">
        <property type="entry name" value="AUSTRALIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16040:SF7">
        <property type="entry name" value="AUSTRALIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10444">
        <property type="entry name" value="Nbl1_Borealin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Borealin N-terminal" evidence="11">
        <location>
            <begin position="31"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="104"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="211"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="277"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCF51446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC70674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="395" mass="44602" checksum="5EBDE5FDF1EC4A71" modified="2016-11-02" version="1">MASTKTRRQVPNVIMSTPPAQRSKSAYNEVEKQGLLANFDIEVADKTLYFRSILSRTLASFRMREESEILSIPRELRGMTLGELESKWGGGWTGTLQRIRRESFEKKEKVREEKEEKERDEVVKGKRKRNGTVSTNNSPERGGKNPRRDASTPASQGKAVSTSNTRSKASVASKKGKNVTTPAIASSSKGPSFLPQNHIFNPTLPPTPFFSSNSHSPLSQPSKSKSYPSSSSSNIHPLSKSNPVSDNEKEEEKDDDDENENSEEDEDENDLPNPELLEAKLLKNSKNHSDLNSKSNRNKKKRGPSLIFRQSLISNSILPSQEKEEEEEEENNVNINLSDGRIITFNPFNLTPGRVDKELNQNQSKLSQNEKKKVQEQVHDLVVKSLRERMERWKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I7M0</accession>
    <name>A0A1B9I7M0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Nuclear proteasome inhibitor UBLCP1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I206_02232</name>
        <name evidence="16" type="ORF">I206_104694</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 18">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012737.1">
        <property type="nucleotide sequence ID" value="XM_019153997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I7M0"/>
    <dbReference type="STRING" id="1296096.A0A1B9I7M0"/>
    <dbReference type="GeneID" id="30170601"/>
    <dbReference type="KEGG" id="kpin:30170601"/>
    <dbReference type="OrthoDB" id="1711508at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090364">
        <property type="term" value="P:regulation of proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000239">
        <property type="entry name" value="HAD hydrolase, family IIID, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011943">
        <property type="entry name" value="HAD-SF_hydro_IIID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051658">
        <property type="entry name" value="UBLCP1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02245">
        <property type="entry name" value="HAD_IIID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48493">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING CTD PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48493:SF1">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING CTD PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="13">
        <location>
            <begin position="158"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="FCP1 homology" evidence="14">
        <location>
            <begin position="291"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF51518.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC70743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I7W3</accession>
    <name>A0A1B9I7W3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">U3 small nucleolar RNA-associated protein 21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_02235</name>
        <name evidence="6" type="ORF">I206_104697</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0032040">
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        <property type="evidence" value="ECO:0007669"/>
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    <dbReference type="GO" id="GO:0006364">
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
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    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
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    </dbReference>
    <dbReference type="InterPro" id="IPR059157">
        <property type="entry name" value="WDR36-Utp21_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007319">
        <property type="entry name" value="WDR36/Utp21_C"/>
    </dbReference>
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        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="65"/>
            <end position="335"/>
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            <begin position="301"/>
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    <feature type="repeat" description="WD" evidence="1">
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            <end position="655"/>
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    </feature>
    <feature type="domain" description="WDR36/Utp21 C-terminal" evidence="3">
        <location>
            <begin position="743"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25171"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF51521.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC70746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="949" mass="103846" checksum="9E67017C321F237B" modified="2016-11-02" version="1">MAHQNKRQKNGVATTVAEQPAAGPSKPTPRLFAPFRALGHVTDHVPYAMFVHTPQGALATPTVNITTSVGRSWLMWDAARMTLVFAGPDTGAQINSLAMTGTEIFASAGARVIKYHRGKETGSYISPDQSNLGKILIFGDELLVLKEDGTGMVIYDLKGGQLKNQITFHSSFTATHLMHPSTYLNKILIGSQQGELQLWNVRTCSLIHTFPHPTPASSSPVTAIVQSPAIDVVGVGYLDGVVRILDIRQGDLVMQMKIEDGAVAGLSFRMDGPPILATASSTGSLATWDLSKGGRVLHVVRGAHDQSVTGLQWVPGQPLLVSSSVDNSVKQWLCDDPTGMPRLLKFRGGHHAPPTCIRYYGEDGKQILTAGRDRSLRYTSVVRDSRSFELSQGSLIKKAIGLGVTVDHLKYPQITAISSSSIRSKDWEDVVTAHADDAVARTWRVQEKRLGPWTFEMDSGVAQAVTVTACGNFSLVGSSTGEIRMYNMQSGKERRSFSLSGSAPGDSKPKIIAQSKTAKAKATQQQAAEGVKKTLEAITGLVSDALNRIVVASTLEGKLYFFDFHTTQLLHSAQLSTSITSMSLNRDSGLLSVICDDLTVRLIDIDTRRVVRELRGFKGRILDTVFSPDSRWLIATSLDSTIRTFDIPTGRLVDAFKTSSIATSLTFSPTGDFLATAHVDSVGIHLWANKAQFSEVALRHIPEEEDVPEIGLPSVQGLAEDAAIEGVEAIGAPEFTDIYTTPEQLSEGLITLSLIPRSRWQTLLNLETIKQRNKPKEAPKAPEAAPFFLPTVSGLETRFDLSAAEDQNDAQQNGKNGQRLDLASGWLESEFTKRLTREDESGDYNTFYEYIKSLPPSTLDLEIRSLSSLEHLLAFLNSLINRLKSNKDYEAVQTILSIFLSVHNDLLIQNPEEFKIKLIELKEQQNKHTKRIRELVGYNLGTLGFLRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I7X6</accession>
    <name>A0A1B9I7X6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_02350</name>
        <name evidence="5" type="ORF">I206_104811</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012854.1">
        <property type="nucleotide sequence ID" value="XM_019154114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I7X6"/>
    <dbReference type="STRING" id="1296096.A0A1B9I7X6"/>
    <dbReference type="GeneID" id="30170719"/>
    <dbReference type="KEGG" id="kpin:30170719"/>
    <dbReference type="OrthoDB" id="3362246at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37487">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37487:SF2">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628422" evidence="3">
        <location>
            <begin position="20"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF51635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC70859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="240" mass="22395" checksum="AE1D2D6BF14B7C91" modified="2016-11-02" version="1">MKFIASIVSTVALLGAAIAQQTSGDITVNSPASLVQCQPAALSWSGGTAPYIVAAIPGGQPSAAALTTISQSEQGNSLTWTVDLPANTQITIKLTDAKGSIQYSSPVTIQSGSDSCLNGASSSGSSGNSTSASTSSAASGAVAGTSASGASGAASSAVTSAASGAASKTTATSTAPTSTVTGSSPASGSAKPSGSPSGSASGSLAPSASSTGANSGALPNGIVTIPAVVFAALGAIFALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I7Y1</accession>
    <name>A0A1B9I7Y1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_02314</name>
        <name evidence="4" type="ORF">I206_104775</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
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                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
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        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
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    </evidence>
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</entry>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">CBS 10737</strain>
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    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
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                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">CBS 10737</strain>
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    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000094020"/>
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</entry>
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    <name>A0A1B9I8V3_9TREE</name>
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            <fullName evidence="2">Alkaline phosphatase D</fullName>
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        <name evidence="3" type="ORF">I206_105119</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Cryptococcaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
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                <person name="Litvintseva A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="David-Palma M."/>
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                <person name="Mohammad A.W."/>
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                <person name="Yurkov A.M."/>
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                <person name="Litvintseva A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013375.1">
        <property type="nucleotide sequence ID" value="XM_019153214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I9D7"/>
    <dbReference type="GeneID" id="30169810"/>
    <dbReference type="KEGG" id="kpin:30169810"/>
    <dbReference type="OrthoDB" id="2575738at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF52156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC69612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="259" mass="30387" checksum="D2E2158628E96CB8" modified="2016-11-02" version="1">MYTPSRKAPLPPISNDFENRYFVNTLPPNHPFATYYIPSKETHHQYKSDSTSSSLYSDIKSKYEISSKYTYNSTKTDRLYERNSSIKEKSPISSLSKPLKPINTEYSLLGHFNNQSIDQNNNNNDKLKYRKEEFNKHPAYSRLTISSSSSSNSSFDLIPTELTLFNKKSKYNLLYDLEFILGKKINFPFLNKNKNKNKNKNKQNIFESKNRNRKEKNNRLIKNKYVDDLEWESLNGLLPEHVVIVEKRRGRGVREGSYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I9L0</accession>
    <name>A0A1B9I9L0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">WD repeat-containing protein 75 second beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_01458</name>
        <name evidence="12" type="ORF">I206_103538</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013392.1">
        <property type="nucleotide sequence ID" value="XM_019153231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I9L0"/>
    <dbReference type="STRING" id="1296096.A0A1B9I9L0"/>
    <dbReference type="GeneID" id="30169827"/>
    <dbReference type="KEGG" id="kpin:30169827"/>
    <dbReference type="OrthoDB" id="4096at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000234">
        <property type="term" value="P:positive regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057644">
        <property type="entry name" value="Beta-prop_WDR75_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053826">
        <property type="entry name" value="WDR75"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23869">
        <property type="entry name" value="Beta-prop_WDR75_1st"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23769">
        <property type="entry name" value="Beta-prop_WDR75_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="163"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="390"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="WD repeat-containing protein 75 second beta-propeller" evidence="10">
        <location>
            <begin position="501"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1008"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1030"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1072"/>
            <end position="1082"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCF52173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC69595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1082" mass="117775" checksum="2FECE9EF081720E5" modified="2016-11-02" version="1">MAEKNGSSSSQTLTSVNTPSQKAGRSRRRNPKSTVEGEFIRDPSRAAISSPKGKERALDHLPPLQSLSEASADKKLKKHKKKERTGPRGESSTAGAIAEGSQRRKDGNSWDLIPVAQNEISRIPPVWAHDGKFYFTVTHTSIHIHSSSAPSFTRLSTLSSTHREGHTKPITSLHLSPTNSFQVISSSEDGTIKVWDWVVGRLIRTIKFTETQAKVQHVTFGQVAEKWWMFAAVTHSKDASGQKLTHRVLKVPLTGSTSPYVVGKLSAPPTALMMSPRSTYLVALSATKAYTYRMPSPSSDSSIDIWENRPTCVKFVSDQAFTCGAFSPENTLATSSEEEWFATGDEKGVIRLWHGLAQAFRQVDLASQAILGQSSNSNAETEKRLPTTSLHWHAHAVSAIAFTPSGSQLLSVGEESVLVQWHLASGKREYIPRLGGRPIINLAVKKSSHGSEEEWWMSLADGSTIRVGSASGQITNIGQGIRLDPLRPTSSTKTYPFSFHPATSTLVVPSSHPSTLQFIDPIASSVLFDLEVAPSNRISKRGQKELESVQVDQVDFSASQDGQSAWMATFESRTGDDSEGGGRVKNLKIWRWQGERYAINTQFPRAHGQSPLTSVKFSPLQQVSSTSSSKSVLLTPYLLTASADGIAKIWHARQSKVSQQGKVAAARPTFSEMYWSCRSTFDYRGLPIYDSAFSPDGTIVVLAHGAVVTLWDVDSNVLLKAFDTKSGSDVRKINFVGQEGRYLVGAGELRGIIVWDLLSCETAWTIQDYQAQNLVVSNEFFLTSSSTNKASIITVFSPESSTPIRSLSITRPVIHLQLLPSPSKSVTSLHLVGVASSGEIFRFGDLAHSAAPLSAKDVSTNAKGQNQASSIWQEMFGKDAFLDVAIGEPEQENATATASALQQNIVRGKGKPADVFNGPSHTMPPTSILFDAFMDELLSGHTTSGQRDEEVAHDVDDDIPIAYHEDTVVQADLPTRIVKDNKVEDGEIKELESFFRDLLGNLTPANTTNIAKTPASKKMNGHLPNGDHTPITTTPTNKQPIVNGIHSNAKSGNADESMEIDTPASKRGSNSKGKKRKALRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I9Z8</accession>
    <name>A0A1B9I9Z8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_01560</name>
        <name evidence="4" type="ORF">I206_103437</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="Zeng Q."/>
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                <person name="David-Palma M."/>
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                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
                <person name="Sun S."/>
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                <person name="Young S.K."/>
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                <person name="Litvintseva A."/>
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                <person name="Wortman J."/>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        </citation>
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            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">After transfer of sugars to endogenous macromolecular acceptors, the enzyme converts nucleoside diphosphates to nucleoside monophosphates which in turn exit the Golgi lumen in a coupled antiporter reaction, allowing entry of additional nucleotide sugar from the cytosol.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.42" evidence="5"/>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013765.1">
        <property type="nucleotide sequence ID" value="XM_019153604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IAF6"/>
    <dbReference type="STRING" id="1296096.A0A1B9IAF6"/>
    <dbReference type="GeneID" id="30170206"/>
    <dbReference type="KEGG" id="kpin:30170206"/>
    <dbReference type="OrthoDB" id="6372431at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009134">
        <property type="term" value="P:nucleoside diphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24040">
        <property type="entry name" value="ASKHA_NBD_GDA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF83">
        <property type="entry name" value="GUANOSINE-DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01238">
        <property type="entry name" value="GDA1_CD39_NTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="49"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="144"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="215"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="436"/>
            <end position="440"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCF52546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC69221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="704" mass="77076" checksum="B83F306984B7B1F8" modified="2016-11-02" version="1">MTARLAEDEDTLSSSSNSSSSIIATPSSDSLINNLDSNLRKRHSVKGENLDSKLLNRQRNLDKTPASPKINIAPRMFSSRKYSPLPTSSNGSNRKRAGSGITSWKRYALIGTAVLVLLALGYTQFGGRANKEILWDEENTYTPALDDDIVSGDGVDYSSPPFRPLDSDVAKPASNHQQGDDDEEEPTFHALPIGHTNKPPADDEVDEDIEEANDKPSSSPHDPTTTEAQDASHASEDFTEVTDSSEESTGFPASFEDDPNPQGTTACTSPHSDEKPIVQYALTIDAGSTGSRIHVYKFNNCGPSPQLEYETFKMLNPGLSAYARDPTAAAASLDPLLKEAYRVVPKELWKCTPVEVKATAGLRLLGQQESVAILDEVRNRLETNWDFVVNGEKSVEIMDGKDEGVYAWITANYLLGKIGEGVASDVDTLAVMDLGGASTQIVFEPKFPVDSTQKLVEGEHKYQLNFGGKDFTLYQHSYLGYGLMRARRSVHNLIAFTWSFGQGQVHWDEMDEGIQIPNPCLTKGSSRRVELDPPGRQAVNVTMHGANGGFEACNRVVELVMAKDAICEVKPCSFNGVYQPSLLDTFPRGQLLALSYFTDRIKPLFPDTSLLSISDLTNLAKDVCAGPEVWNKRFGNNPIALEELEDRPEYCLDLTFMNALLGLGYELSQERELMVEKKLKGVELGWALGAGLALVENAKLTCTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IB48</accession>
    <name>A0A1B9IB48_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_01924</name>
        <name evidence="3" type="ORF">I206_103072</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013850.1">
        <property type="nucleotide sequence ID" value="XM_019153689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IB48"/>
    <dbReference type="STRING" id="1296096.A0A1B9IB48"/>
    <dbReference type="GeneID" id="30170293"/>
    <dbReference type="KEGG" id="kpin:30170293"/>
    <dbReference type="OrthoDB" id="10260741at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21449">
        <property type="entry name" value="DLC-like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255:SF7">
        <property type="entry name" value="DYNEIN LIGHT CHAIN TCTEX-TYPE PROTEIN 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255">
        <property type="entry name" value="T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF52631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC69136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="134" mass="15174" checksum="5AAE1A26710F5644" modified="2016-11-02" version="1">MTSISRLNGTLSPSIPSRSGASSPLRQKFPSDNLRPFIKTLLIKTFTNLNWDLNDKLKMSKYSKEVSEKVKQRMIEIEPRGFKYIVTTTLTENLGQAGRADLACHWEDTDSAIQEMFSNDSIIFTCLAFAIRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9ICM6</accession>
    <name>A0A1B9ICM6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bud site selection protein 31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_00452</name>
        <name evidence="6" type="ORF">I206_100874</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="Litvintseva A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC66517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019152681.1"/>
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    <dbReference type="KEGG" id="kpin:30169274"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
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        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GATA_ZN_FINGER_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="1234"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
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            <end position="217"/>
        </location>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="1193"/>
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        </location>
    </feature>
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        <location>
            <begin position="1282"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
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            <end position="1475"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF53600.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC66517.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1475" mass="157656" checksum="9E28B6F846110C43" modified="2016-11-02" version="1">MSSRALHRSNADFTPIELPSYPRPQQVNADGYEIDYDLLQPNGQKIIAIEQDLIRDELEGGEEAEEVDQDIGGEEDIDMNGIEADDEVENLDDSEKIDKEPLLSLADSLVLPYSLTQTRYHHLTSLLPHIFSHPAIPSHSKPRARPPPKGTFLFPTPPAPIQPLPNPEYHGPSLSAEAPKQGDSSKSAGTTEVPLTGTPPPTGKPSRPSRPKKPINEEWPAHEMECISRCTLSVGPISFPGTEIWVGRFVEPKVTLPKPQRAKPGERKEKRKSLASSQDSIKRSRARQTGVERSIGTPNRLHSRPPSSSSSHNPTPLRPNTPTAYAPRPPIYRPSPGPAFPVRPIPQPNRPTTASPHLIQLVNQAATRHAWLSALIYKAAGSTANQVELERLGKAVARLSRGEPIEDLAPPETLSATPGSGPSAASAAQAPGLAHPPAQPTGPNSTDTVLAPRQASDGSSINPTVSPMKTSTSGLNSHPTTSSVSTQGSKDTTATELPVVEANSNQAPATTADDSDSDSDVDMSGRPQVGGGSLPLHSDPAEQSDVQAHEYTSSVPNPAASASTTAGTTTAPSHPSIDPAQPDDSVSSAASPQSQVPPVSASTRTTQNPLISQVRDTPLSTAAYAMNPASHMGMSPGISPASNNAVISPLNPVTNSLASRPQTVAPLIPPLAASVPPLHPTNPPVPPFAQPPPPPQIATNTPPPPKPTYPLPPPFLLIAFKEQPTEKYLLPLGIRSFISRVGGEYVTGPRPPEPDSLSIPAPASIAVNREISFIPTQAELGSPTVPTASSEPTTESIAGTAPFPPIDPTVIIPVPTKPLRNRTRQSLGRHAKELPDPATDSLPSEPIPLSDTEVKAEPEIIVRSRPQSGLTPLPGQKPEAGTILISTILPSGLARWEKIEWDDIKKGLPFDNPEFWDTSDKPLTEVKEEPQEPSSPVVPQQPSRALRHARSTSDMAEKPQKPKNLKPEILNIASKDFVPAEGDVQPVTIRLAGIDDNVWKKMKNIAEITEKHDIERMFEHEPVLLDGIEVYPYRKVEKPSTEIVPLVPENQDPVTPGAPKIQNITRGLTSKAIELLRPTYLARKAAGFTELLKRVPTRSFLQTRVAEPIQEIIDATADKWAPRPYPISTKPLYQADENDNDEEEMIRAPEIEFSPPPNKKSKKGEESAVTFEVPVSYDRLDEKVAEGVKNSVLNARGGRSGRKYTKRASTGGDGGDKPKRQGNKGKRGVQNGICEGCGMENIKVWRRGPTGRSTLCSPCGDLFVAKKLPPLKRPGAMKAFLSANGGGVDGEDEGGDADEKNESEGEKGAKEGGEAENSVRDTTGLHEKDNAGETREVGPAINSRVDGGQQDPSKLQDDQFVPKTTSSAPEESASVPEEGPSVPIGVQDVENSRSELDDSRIDETETADPALTEHSIPDPAGTSVSIGFKEPGGLSHGEESGISSHPEGPSKEVETVGVTNPKAPPEEDKNMDVDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8KZS5</accession>
    <name>A0AAJ8KZS5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_100628</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="WWC66723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019152476.2"/>
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    <dbReference type="KEGG" id="kpin:30169066"/>
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        <property type="component" value="Chromosome 1"/>
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    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03013">
        <property type="entry name" value="PRX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037944">
        <property type="entry name" value="PRX5-like"/>
    </dbReference>
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        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430">
        <property type="entry name" value="PEROXIREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PEROXISOMAL MEMBRANE ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5 7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="70"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="6">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR637944-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC66723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="224" mass="23790" checksum="FB9F9F00ACB1779A" modified="2024-07-24" version="1">MSIKPSFAPRVLRTNRLIRPSSVVSRSITSSVRPTVQTPLVKQYRMASVLQATAKAAHSAVASLASAAPIKVGDAVPDVDIRINDLEDKVNFSKLPGKNILVLVPGAFSPTCSSQVPGYLEQFSTFQSKGVKDIYVVAVNDMFVVNAWKEKLAGDKNTVKFAADDTSALAAKLGLVLDAQAIFGGPRLKRGAVVIEDGKVVHVAVEPSPGEVTVSHADEVLKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L004</accession>
    <name>A0AAJ8L004_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I206_100927</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10 11">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Vacuole membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058396.1">
        <property type="nucleotide sequence ID" value="XM_070202295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L004"/>
    <dbReference type="GeneID" id="30168768"/>
    <dbReference type="KEGG" id="kpin:30168768"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000001">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="18"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="94"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC67020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="167" mass="16871" checksum="ABBA56A8F2EAF63E" modified="2024-07-24" version="1">MSTVAELCPVYAPFFGAMGCTSAIVFTCIGAAYGTAKSGVGISAMAVLRPDLMMKCAIPVVMAGIIGIYGLVVSVLISGNLASPMPLYTGFIQLGAGLSVGLAGLAAGFAIGIVGDAGVRGTAQQPRLFVGMILILIFAEVLGLYGLIVALILNTNSTVDYTCSIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L2V0</accession>
    <name>A0AAJ8L2V0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I206_102230</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 17">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007584.2">
        <property type="nucleotide sequence ID" value="XM_019159290.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L2V0"/>
    <dbReference type="GeneID" id="30175967"/>
    <dbReference type="KEGG" id="kpin:30175967"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF9">
        <property type="entry name" value="CHITIN SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="751"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="790"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="819"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="864"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="992"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1024"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="14">
        <location>
            <begin position="327"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="264"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="11"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="167"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WWC68306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1052" mass="116554" checksum="2BFDEDEDCEE95BDD" modified="2024-07-24" version="1">MNPGDIYTPPHGQQRQQQGYTSPTGQAFPSYPHQQQQQSVPPYGAGSHHYPSDPVPLQHQNQSLMTNPYDTPPPLNQAHSTPQIYHAPAPAPGYGDPFNPPSAPVQHQPQGWAEPQGNRHHISQPLSPSHQPQQIGGPRYSIPVQGNQNPYASPTPAPLSPPRTRFDSNPSYYSAHQSSYGGLSDHRLSSPPPLLPHSSSSSSSMMGVGLGQRPSYPPHGYDNHVAGNQDDDINDSAPLLSHAAPDPRFGIPQSTSAMSMNGPNGRGYQLSDTGPALGNGGDVGMLPGRWEDNEQQRNGYAAPPNQDEDEVNVHYGPLPPRVVRRNRTQKRVQLFRGHLVLDIDVPTMLLDQCPIRDDNEFTKMRYTAVTCDPNDFVEDKYTLRQKLYDPPRQVELFIVITMYNEDDVLFCRTMRGIMQNIAHLCTRSKSKTWGKEGWKKVVVCIVADGRLKINPRTRSVLAALGVYQEGVGKNVVNGKPVTAHLYEYTTQLSITSNGKIGPGGSNTVPIQMIFCMKEKNQKKINSHRWFFNAFGACLKPNVCVLLDVGTQPGPDSIYHLWKAFDINSSVGGACGEIVALKGMFWKNLLNPLVAAQNFEYKMSNILDKPLESVFGYITVLPGAFSAYRYIALLNDDHGNGPLKQYFVGETMHGAGAGIFSANMYLAEDRILCWELVSKRQCKWKLHYVKSAYAITDVPDTVPELVSQRRRWLNGSFFAAIHSIVHFGYLYRSSHSFTRKLFLHVELVYQTLSMIFAWFALGNFYIAFFVLTSSLNSLGSAWKYVNTPLHYLYIALLLWCFLLALGNRPAGSKIGYTSSMVGFALITVYMLFAAIYLAVRGIQSITADGTITADDVFGNKIFRNIVVSLAATYGLYIVSSLLALEPWHMLTSFLQYLLLAPSYVNVLNVYAFCNVHDVSWGTKGSDKVSEDLGVVKSDSKDEVTVDIPVEQQDLNEVYASELRVLATKAPKEVKIVSDDQKQEDYYKNVRTNVLLAWTMSNGALAAAILQTSGGDSSLATTYMGILLYTVAGLAFFRFVGSTSYLIVRLFAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L348</accession>
    <name>A0AAJ8L348_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_102175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC68252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058617.1">
        <property type="nucleotide sequence ID" value="XM_070202516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L348"/>
    <dbReference type="GeneID" id="96955712"/>
    <dbReference type="KEGG" id="kpin:96955712"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WWC68252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="98" mass="10826" checksum="1BC98DC9CF933337" modified="2024-07-24" version="1">MQLILLKGSMLLSQSLISTQFNITLWMSTLPISSYLAKVVSGILPSKSPIRNSSDRFGIVTRLSADLRKSDHAPVMVHKKITNRTSTVASNITFTSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L601</accession>
    <name>A0AAJ8L601_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HhH-GPD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_104163</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010957.2">
        <property type="nucleotide sequence ID" value="XM_019155999.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L601"/>
    <dbReference type="GeneID" id="30172631"/>
    <dbReference type="KEGG" id="kpin:30172631"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045138">
        <property type="entry name" value="MeCP2/MBD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074:SF0">
        <property type="entry name" value="METHYL-CPG-BINDING DOMAIN PROTEIN 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074">
        <property type="entry name" value="METHYL-CPG-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="4">
        <location>
            <begin position="275"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="134"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC70213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="505" mass="59429" checksum="9BC34EAEE32C77A9" modified="2024-07-24" version="1">MLRALNLLGQCKYEYLRFDTFPSNVDEQENIFQPQTSSKIKSSIDFSSFSNSSSLLEEFSDSSSSSSNSKSIKSYDFKRNNIENFINISPYFRKINDNMKTRNQIQNERKTLNKDEEINLINHSPKIPTSIIVNDKLELKKEKKKRKVEKEVCNENQNKLPTLENLSKSKKRKRKEVEVLIEIPIKRKIKTNIKDNIEKTFKNDEDEEKVKKKVKRKKKKEVKINLIEDYDLLNSKKKEEKEIIGKSEKGIIENIGKIHLIQEKLRFDPWKLLIATCLLNKTSGRAALPILEILLKKYPTPKDLSEASITDLSNLLYPLGLFNQRSSTLIKFSSQYLNYNWPLYNPFYNNSNSNSNSINQPLLTRNIKRINNDKPIPENLDVKIFYGSGIYASDSFRIFSNLNLGKGAPENEIKWLKKGERSKKRMKNDWNGSIDELGEYMSDEDELQQLQQEEEEWRKVIPLDKELRRYLIWRWGIEGIIYDIHTGPRIVRERDKKRLKYLLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L6W7</accession>
    <name>A0AAJ8L6W7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_104152</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the RNase T2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059011.1">
        <property type="nucleotide sequence ID" value="XM_070202910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L6W7"/>
    <dbReference type="GeneID" id="30172642"/>
    <dbReference type="KEGG" id="kpin:30172642"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="Ribonuclease Rh-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042462658" evidence="4">
        <location>
            <begin position="22"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="252"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="303"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC70202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="328" mass="37131" checksum="5F97AB8D1576043B" modified="2024-07-24" version="1">MRRIQISTFFLFPSILAVVIAQELSCSTTNLDPCSVPSPGGLFVFRQRFEPDVGSDHGSWGIDGLEVLDCTTQKSQDKISYLPTYTHEEIGSYCAKSSLFGGEKGYNDAEKEWAQSEVGEGVEEVWERTWNTAGRFISTFDHKCFEKSQAGMGVAEFFLVLSKLQRNFLTAQLLSDADITPSDDTTYSLRELTEALSTIDHKPLVQCHNTTLTSVSWPLNVKGKFDSGSFQAAAKFERKSNCPLEGIIYPPSTTLTPTKKSDDEEWEHLRRPPPRPITLSHDESRLYYRKEAAKEDPVVKLGLRKEHDEERDELKGERAGKQYWRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L7T7</accession>
    <name>A0AAJ8L7T7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_105733</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059277.1">
        <property type="nucleotide sequence ID" value="XM_070203176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L7T7"/>
    <dbReference type="GeneID" id="30171733"/>
    <dbReference type="KEGG" id="kpin:30171733"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF39">
        <property type="entry name" value="TRANSPORTER LIZ1_SEO1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC71774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="501" mass="56027" checksum="B7B956B59EEAEE12" modified="2024-07-24" version="1">MVPASTSSSPGFDSSEKYVYPKESDLLPVLSGGRWYSKLWDSWDKPREERRFLLKLDLTLLSAASFGVLIKFIDQAAVNNAFLSGMKEDLDLYGNELNYAAAFFAAGYVFGQIPSNLILAKGIVKAHIWIPILEVLWTVTTFATSSVKTAGHLYACRLFLGLFEAGHFPAVMYVASSWYTPAELGKRLTLIQISVMVGPMFSGFLQAGIYSALNGVQSRAGWSWLFLIDGCISLPVSLIAFLFIPDLPFNITKSWLFTQEEIDLARVRKPLESYEKNPPLNWHVWRGILTTWHIWVFPTLFTFMGLCSNPSTSMGFWFKAWNTIKPHSYSVSQINIYPTPIYGVSVVYGLIGAWMSDSVLRGRRWPPIALAFCITFGVNIALATLPVYSQRKAVRWGLYYISNLVLGNFGVMWSWQAAATEGNPIKRAVVGATMNSMSTLINAWWPIVLFPTQNQPVVKAGNYATAGLSAGGLLLIPTILYLQRRDRQRSNQAEEQTEPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L8X5</accession>
    <name>A0AAJ8L8X5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chitin synthase</fullName>
            <ecNumber evidence="5">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_104938</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the chitin synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="5"/>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059129.1">
        <property type="nucleotide sequence ID" value="XM_070203028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L8X5"/>
    <dbReference type="GeneID" id="30170846"/>
    <dbReference type="KEGG" id="kpin:30170846"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF38">
        <property type="entry name" value="CHITIN SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="353"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC70985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="384" mass="43045" checksum="5C849E14E27B1C1A" modified="2024-07-24" version="1">MTSPHQDRILCFEIVAKKKANWVLKFVKSAVGETDCPDTIPEFIAQRRRWLNGSFFAAVYSLIHVAQIWRSDHSFLRKSALMLEFAYNALNLLFSWFSLANFYIFFVILTRALEGEAFNIPRIDILNSIAQVMACFIFGMGNRPQGSPLKYKATIYFFAVLTTYMLVAAVLCTVQAIKNFDSPIFSRMIVSLISTYGIFIASSVLALDPWHLVTCFIQYILFSPTYVNVLNAYAYSNLHDLSWGTKGSDTVQESDLGAVQGVGKHVEVELVSAQQDIDIAYQDALDNIRLKGARVDEDKKKDNSEQAQKDIYANFRTNLLLCWSLSNALLASVILSGSTTGTFDAAGNSRTGIYMLIILVFVAGMALFRFICSTLYLIIRLFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L907</accession>
    <name>A0AAJ8L907_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I206_105734</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059278.1">
        <property type="nucleotide sequence ID" value="XM_070203177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L907"/>
    <dbReference type="GeneID" id="30171732"/>
    <dbReference type="KEGG" id="kpin:30171732"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042534263" description="FAD-binding FR-type domain-containing protein" evidence="13">
        <location>
            <begin position="23"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="14">
        <location>
            <begin position="376"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="639"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="689"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="639"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="664"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WWC71775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="809" mass="91709" checksum="B924182AADB34D99" modified="2024-07-24" version="1">MARPSLFIIWLVTLIQVQLIRADNLQVYLQTPDYECVYACYVALTPVSFGDITAKKPTIANQCNSTDFASSLALCSETYCDEKHQDAGWTYMTQTCKKSKITLKKQATYTAQIDKSTVTTVDAIAQKKKTFNGTVLINQRSWEVGYRTLSHGFGFAVYLFMVTAVLIGVINRLISLSVHQFAKDLSPENASSPTVTSKHSIRSRTYTWWRKNITLPASFGYRHAQPWGWVSIPTRLQSILIFFFVAINIIFMCVGYDLFDENILDPDDKQAQLLDYLQYRTGVMCVYNMPLLWMLAGRNDVILWLTGWSYSSINLWHRWVARMAVLQALIHGVAYTIIKKDSLYERFFHRMYWATGIFALICFVFLVVLSIKPIRSRWYELFLITHIALALMSLVLLWFHLTHMKGKYDPWVWACAAIWCLDRAIRIARVLVLTHKALSKKGKNTVAIMSDNESGLIRLSITTSIKMTPQPGQYYFIYQPFSIKPWENHPFTLASWKTDDASKSTTLDFLVAPQKGITKKWRKRILKTEKKMDHTRFLLEGPYGHSNPVQNFEHILLVAGGSGITSMLAYIHQLQNHSEDLKQIRTKTLSLIWVVKHTAYASDVLDNELKAFVNDCNTIPGIRVDIQLYISRSGDSSPNRMAIGSLNSESSTSTPAMTRKNSDWDNSPPTTKNNSMLHSVPLLMRKESNHTSPTISSMEAFPEKAGEEDAEGQLQHIPLEDPLVKAEQEKQGVIIGTSGLTLHSGRPTMNNLIDLGLERLVGGERLAVSACGPAKMVDDMRQAVVNAYGSEEGKINGSTLEYFEELFSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L9S0</accession>
    <name>A0AAJ8L9S0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional repressor Tup1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_105698</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the WD repeat TUP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059272.1">
        <property type="nucleotide sequence ID" value="XM_070203171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L9S0"/>
    <dbReference type="GeneID" id="30171768"/>
    <dbReference type="KEGG" id="kpin:30171768"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000503">
        <property type="entry name" value="Glucose repression regulatory protein TUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013890">
        <property type="entry name" value="Tscrpt_rep_Tup1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08581">
        <property type="entry name" value="Tup_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Transcriptional repressor Tup1 N-terminal" evidence="11">
        <location>
            <begin position="37"/>
            <end position="112"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="331"/>
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        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="390"/>
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        <location>
            <begin position="425"/>
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        <location>
            <begin position="486"/>
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    </feature>
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        <location>
            <begin position="528"/>
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        <location>
            <begin position="1"/>
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            <begin position="17"/>
            <end position="28"/>
        </location>
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            <begin position="113"/>
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        </location>
    </feature>
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            <begin position="177"/>
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        </source>
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            <dbReference type="Proteomes" id="UP000094020"/>
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    <sequence length="568" mass="62676" checksum="5A2E663D706D290B" modified="2024-07-24" version="1">MQPPIYNHHRLPPAGAPSQQQQSNQQPSVLSASSNARLNEFFDLIKNEFEQVGQDGNVWKAQRDEYEAKIQQQINELGLIRQSLYELESNHAKVRQEYEGEIARLRRELEARGGPGGGPSGPSAGGQTSPPDLPRPGNDERPPYGNSLPGPPLNGNEPGGSRSPYPPPGGIIPRPASTDRERDRRNRERAIAASNVPPSPPVHLSDLDPDNVSRELKKEGGDWQAMWSSQMRKQLDVALVHTLEHETVVCCVKFSNDGKYLATGCNRTAQIYDVKSGGRVTTLQDEAANRTGDLYIRSICFSPDGKFLATGAEDRQIRIWDIKQKRIRHLLQGHMQEIYSLDFSRDGRFLVSGSGDKSARIWDIEKGLCVFDLRIEDFIHNEHGPIDAGITSVALSPDGKLVAAGSLDTMVRVWNVQTGQQVERLKGHKDSVYSVAFSPDGKCLVSGSLDRTLRIWDLTGTKREAEILAPGSKDIQKNLGTCQSTLNGHKDYVLSVAISPDGQWVVSGSKDRSIQFWHISTGQAQLMLQGHKNSVISIDLARSGGYLASGSGDCMARIWKYEPYSGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L9S8</accession>
    <name>A0AAJ8L9S8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_106093</name>
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    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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        </lineage>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
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    </reference>
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            <begin position="173"/>
            <end position="191"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="354" mass="38548" checksum="47262C364C28BA5F" modified="2024-07-24" version="1">MSGNKDNGFSEMGSPHPSSTTSCRPVTNTLITTVTSQGTVITTRVLIVPTLTVMQGEAITLQVNLNEQGDLMDTQTSSTNLTKAQDSSVASTVTITTFASASATAHSPLSKGENDGVVVKPKNSKFTKKDYIPAWKRDTQLLADERGGTVVGRCAVLYGWDINSLDNFVREEIVLATFFMWILGLAILGLLNESIPHFVDVLPVYLNKRIGIQSTVLGLTISTMIASACLCWKIRDDLDWQTFQRIDAFTKVNSIYKLVLALSTMLQLEAFVLVTFSALFLDQVSLADFLYLEETNERSNEGFDENSSMPVPMPQNNLPAFSTAIGPGPATPPRQMFPPMPLCMTATRASSTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ8L9T8_9TREE</name>
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        <submittedName>
            <fullName evidence="12">Protein transporter SEC13</fullName>
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    </protein>
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        <name evidence="12" type="ORF">I206_106108</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC13 family.</text>
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        <property type="protein sequence ID" value="WWC72148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019156660.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L9T8"/>
    <dbReference type="GeneID" id="30173300"/>
    <dbReference type="KEGG" id="kpin:30173300"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:COPII-coated vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF2">
        <property type="entry name" value="PROTEIN SEC13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="58"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC72148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="332" mass="35730" checksum="53B797BD204A6C96" modified="2024-07-24" version="1">MSTALASKPVPVETQHEDMIHDAQLDYYGKRLATCSSDKTIRIFNVVKGEAKGEPVILKGHTAPVWQLAWAHPSFGSLLASCSYDGRVFVWKEVGTGQGKGSGGELQDGWERIKEHTLHTASVNSIAWAPYDLGPILACASSDGKVSVLSFQNDGSTDVSIFPAHGTGANAVSWAPSVVSSAPPAAGRAQPNQISPQKRFVTAGSDNLIRIWGYDEEAKKWTEEEVIKGHEDWVRDVAWAPNIGLPGMYIASASQDRTVLIHTRPSPTSPWSSTPLLPSLPGSQDPHFPDAVWRVSWSLAGNILAVSCGDGKVSLWKEGVSQGWECVSDFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LA95</accession>
    <name>A0AAJ8LA95_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Ataxin-3 homolog</fullName>
            <ecNumber evidence="4">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Machado-Joseph disease-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">I206_105916</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Acts as a chain editing deubiquitinating enzyme that binds and cleaves 'Lys-48'-linked polyubiquitin chains, with a preference for chains containing four or more ubiquitin molecules thereby modulating protein degradation by the ubiquitin-proteasome pathway. Probably by regulating the IGF-1-insulin-like pathway, regulates lifespan. Regulates germline DNA double-strand-break repair and apoptosis in response to DNA damage by recruiting E4 ubiquitin-protein ligase ufd-2 to DNA repair foci. Interacts with key regulators of transcription and represses transcription. Acts as a histone-binding protein that regulates transcription.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 24">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Forms a complex composed of deubiquitinating enzyme atx-3, adapter ubxn-5 and cdc-48.1. Forms a complex composed of deubiquitinating enzyme atx-3, E4 ubiquitin-protein ligase ufd-2 and cdc-48.1. Interacts (via RRDR motif) with cdc-48.1 (via N-terminus) and cdc-48.2 (via N-terminus); the interaction with cdc-48.1 is not required for atx-3 enzymatic activity. Interacts (via C-terminus) with ubxn-5. May interact with ned-8.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="4"/>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC71957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059310.1">
        <property type="nucleotide sequence ID" value="XM_070203209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LA95"/>
    <dbReference type="GeneID" id="30173108"/>
    <dbReference type="KEGG" id="kpin:30173108"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.10:FF:000018">
        <property type="entry name" value="Ataxin-3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033865">
        <property type="entry name" value="Ataxin-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006155">
        <property type="entry name" value="Josephin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14159">
        <property type="entry name" value="ATAXIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14159:SF0">
        <property type="entry name" value="ATAXIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02099">
        <property type="entry name" value="Josephin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01233">
        <property type="entry name" value="JOSEPHIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01246">
        <property type="entry name" value="Josephin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50957">
        <property type="entry name" value="JOSEPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Josephin" evidence="21">
        <location>
            <begin position="4"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="211"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="431"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="442"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="18">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="18">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="active site" evidence="18">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00060106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00069055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00082365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR633865-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="WWC71957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="462" mass="51909" checksum="2CE85D6294686601" modified="2024-07-24" version="1">MDLVPYMYFERQEPGSQLCAQHCLNNLLQAFTYTEFDLAGIANNLDQAENATLDIPHQLKKSYNYDDTGYFSISVLERALEVWDLSLVRWRGEAMRQYQEYPEEQVAFILNLSSHWFPLRRFSTFPPDHTATKRWYNLNSFFPQPEWISPTYLRLVLTQAEEEGYSVFVVRKRTQGTKEGENAGEGQGWQDGGIAVLPECLADTMAVELGEPVGRSGASGTFAQTSNAGTSTNPDTPTVDFPSSSGAGPSSPPARRKKRQEDLTPSDPIEVEEDEYSRPAVTRTRQSSNKSTPKLLATETANDDEDIFDNTTFPLDQHQGDGDDDESIHSEEANGVNSTNRFRGGEEDLFGQEGYERYAGPTDFQFNSRSYDDEDEALQAALKASMNDLPPDWQPPSELPPKEVSSPFRPSEPTPPTESVQPKEVPNKQEDADEEILEDDDAPAHEPSPDEIRRRRLAKFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LAS6</accession>
    <name>A0AAJ8LAS6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Adenylate cyclase G-alpha binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_106204</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059371.1">
        <property type="nucleotide sequence ID" value="XM_070203270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LAS6"/>
    <dbReference type="GeneID" id="96955768"/>
    <dbReference type="KEGG" id="kpin:96955768"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013716">
        <property type="entry name" value="Adenylate_cyclase_G-a-bd"/>
    </dbReference>
    <dbReference type="SMART" id="SM00789">
        <property type="entry name" value="Ad_cyc_g-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adenylate cyclase G-alpha binding" evidence="2">
        <location>
            <begin position="472"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="674"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="513"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="542"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="682"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="708"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="730"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="753"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="771"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="834"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC72242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="864" mass="89780" checksum="136C484C15A64DC9" modified="2024-07-24" version="1">MSSNQTSTSSYTQLASPISTQPPKRPTSQLKHRHTSDSSNADVFRLQSTPDNKRQHLDGNGLARNLSSSSLKVLPKMENEEKRRSRPTTSPSIGVNNGDGSMTPDPEDDFDDEEYNRRDSILDPPQQRNPTKVSPLAKRLGEEPPFMLPHPSKDTTTSQAYPGVVIGSFAGGGSTFGEGMGFDGGMGMNMDDIMDPCSSDRAANKTAAAPNIAPWLMDESPSSNSSQFVSQPLEIERTISSKGPAATLREKDSRKASGVLNHFSSVPSLPKIRRQPTVDNSGGYNDSSGSASGSGSRTASHTSIATTIGGSSAYHSIAEEGNSRQRNISSDSLQTLNQRSNRDRSPKFETASSHDRSTSQQSNKSQGSARVGRFGSTTSSNSGGGTTGNEKKKGFLGGFLSKRRTGPSISLDFTPPDTHTRGSTGSTASRVSNPPSIGSLMSSTQGGLSPNDRTPSDSYGKSYRQGSNYTSEGAISPLQEIAETPFHLDMNLDDMEGIVDPSKSGVQPTFARPAPATNNSGATATTDSTAGSMSMEDALAQTSSFATTVSAGGSSGSNQSSAPATGRDLLGEAERLSGPFVRNPFSTTGSSAGSIDGNKPSTPPSPHTLSPRHGLPPTTQPRRPSQLRNVKMGSIDSELSESVDGSAPIAPSWASNGAVQTVFNDPFGTSKALAPIVDESPVPQQGSSVAGESRKASASTTTAEMTGSISALASSAAAAAWAAPESWGVEGDEDESDEESSSSGDGADEEWNDNTNMPIQSSLTESERNNRIPSTASSIGTKLPDVSSPTGVKKPPPFGFKSQQGGSAKGRPPSGRPSTGQGKRGKLNGGRPSTAANSNSGRPGTSGSTHATATAVSLILTRLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LC88</accession>
    <name>A0AAJ8LC88_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">chitin deacetylase</fullName>
            <ecNumber evidence="14">3.5.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">I206_107335</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = chitosan + n acetate</text>
            <dbReference type="Rhea" id="RHEA:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57704"/>
            <dbReference type="EC" id="3.5.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:10465"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.5.1.41" evidence="14"/>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059600.1">
        <property type="nucleotide sequence ID" value="XM_070203499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LC88"/>
    <dbReference type="GeneID" id="96955785"/>
    <dbReference type="KEGG" id="kpin:96955785"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF98">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="10" id="KW-0170">Cobalt</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="NodB homology" evidence="17">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="WWC73368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="232" mass="24367" checksum="D53FE99C96322334" modified="2024-07-24" version="1">MTSFSNEQAFAELYYTRKAIKEILGVTPTCWRPPYGDVDNRIRVIAQGLNLTNYVWSDDSEDWRAGAAGSNVTEADVTANYQSVIKKASDGTYASSGPMVLTHELTNFTMSEFISQYSAIKAAFKYVVPLASAFNTTQPYTETNVTYPDFLTYTNQSSSASASGASTTSGASASASGVTTSASGTTTSASGSASSGTSNTSSNAKSSATARFTIDLFLGSFVVAILGYASLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LCP8</accession>
    <name>A0AAJ8LCP8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_107755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059690.1">
        <property type="nucleotide sequence ID" value="XM_070203589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LCP8"/>
    <dbReference type="GeneID" id="30174457"/>
    <dbReference type="KEGG" id="kpin:30174457"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052898">
        <property type="entry name" value="ACAD10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829:SF1">
        <property type="entry name" value="HAD FAMILY PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="50"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC73783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="424" mass="47056" checksum="F83A469ED79B62C4" modified="2024-07-24" version="1">MVSSSDSGKSSSGGELSSVRSSLPLDKLVPYLEKNIDGFKGPIQVKQFKSNPTYLLTPNSPSQSFVLRRAPSGPLLSPTAHRVDREYLILSALNRYNQGVSPEHAVPIPKVYCLCEDKDVVGAAFYVMEYIRGRVFTDVRLQELDKQDRWACWQSAIKTLTKLSAIPISSLNLPPSFAPLPTAKPYFPRQVGSLLKVSYAQSKAKNKETSEEVGPIWGTDELKNWFTEGAKKVTELEQERGEGGVVHGDYKLDNLIFHPTESKVIGILDWELCTLGSPLADLGNLLLPFSFAPISPENLKKIRNTSKGNDDMTLLLGLKGLSSQETGLPQREELERWWVEGMNDGLRYHHIQGGWEIPIPGMGWVRSWILFRLAIIAQGIAARAALGQASSADARADSRPVFDFFGKMAWEVKKEVEKEGKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MMS4</accession>
    <name>A0AAJ8MMS4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_100995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058413.1">
        <property type="nucleotide sequence ID" value="XM_070202312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MMS4"/>
    <dbReference type="GeneID" id="30168700"/>
    <dbReference type="KEGG" id="kpin:30168700"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042573907" evidence="1">
        <location>
            <begin position="19"/>
            <end position="901"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC67088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="901" mass="86248" checksum="63A5A38B399530CA" modified="2024-07-24" version="1">MPSSSKIIALSLIAGATAAPLNLFGSTSASASGKASVDVGASVNSATTAVSDITGFTNAFLSSATGGAFTAVSKVDTQLGSTVGVARTIAMNTWASAQCLATHKDIKMCTDISAYLSAVYYAFEQGWSAAQLFAALGTDRVNQFEALLKTLCSYADASSTCTPLLAAWPSYVAAVAKQDINAVQQASSALVANGIITIIDAANAGTNLISGLTSGITADATANAQGSLGLNVMGLQLRDAEEKRFLGLENLFGNHATITATAAAQATATAAANAQAQAAGSLNVANLVQAAGSLTAGTAAQAGAGVGAAAGAGAGLISGLTGNIPVVGGLLNGLPIVGGAVNTVEGAVNNLPVVGGVVQTATGLVGGLTGQANGAVGTATNLVGGIAIPGLLSLNGQVGASANAAANAVTNTGANAGLGSVTHGLLGLRSQIPHVANGLDDLASEIFEGDAFAHFSHEYKRDLLSGLLSNPTSILNGLPVVGGLTSGLLGGVTGGQNGGLLGGITGGLLSNPTGAVNGVVNTVDHLPIVGPIVGNTVGSVLNTVGQLPVVGGDVAAQATGALDNTANAGLNVNNGGISLGINDHTAAAGGVAASAGAHLRRGLLDGLPLLGSLPVGNIVNGLPLVNNLPIGSILSNPVGTVQQTVGSVLSNPVGTVQHTVDSLPIVGGLLNGITSNPTSALNGLPVVGGLLNNLPIAGALSAGAQGSAAAQAAANGALNIGTGAIGATVNGATQAATQVAGQTGIHLGQRDLLSGLLGGSQQGGLLGGVLGSSSSSNGQGLLGNNLPIVGPLVNGLTSNLPIVGNLGGVVNGVTGTVGQLTGTLGNTVSGLTHNLPVVGGLVDGLTQSLPLIGANAAAQASGQVNSATNAALNLGSNGLASTLNSVTGLAGGLLGSANLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MNB4</accession>
    <name>A0AAJ8MNB4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5-oxoprolinase (ATP-hydrolysing)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_101325</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxoprolinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058470.1">
        <property type="nucleotide sequence ID" value="XM_070202369.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30175076"/>
    <dbReference type="KEGG" id="kpin:30175076"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049517">
        <property type="entry name" value="ACX-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF26">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19278">
        <property type="entry name" value="Hydant_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="4">
        <location>
            <begin position="10"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="2">
        <location>
            <begin position="242"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Acetophenone carboxylase-like C-terminal" evidence="5">
        <location>
            <begin position="663"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="3">
        <location>
            <begin position="743"/>
            <end position="1268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC67417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1305" mass="141437" checksum="D8BF7EB731B7DB20" modified="2024-07-24" version="1">MPTATDLTGRIKIAIGGTFTDCVAIPENGSPFLVKLLSVDPSNYNDAPTEGIRRVMERFEGKKIGRDELIDTSRISHILMGTTVATNALLERKGEKCALLVTRGFKDLLRIGDQTRPDLFSLHIKRPDVLYEKVVEVDERVTIESRAELLSSDADSSPEGDKYVKGLSGDKIRILEPLDTASVRNNLQQLYDEGFRSIAVTLMHSFTYQDHEIEIGRLAKEIGFTQVSLSSQLQPMIKIVPRGQSATADAYLTPGIQQYISSFSKGFKGGFQDPHGTVVAFMQSDGSLAGINSFSGLRAILSGPAGGVVGYARTCYDPEEGSPVIGFDMGGTSTDVSRYGGHYDHVFETRTAGVTIQSPQLDINTVAAGGGSILFWRNGMFVVGPESASAHPGPACYRKGGPLTVTDANLFLGRLHAPSFPQIFGPNENEALDYDTTRRLFTELTSEINKEVTTPFTPEQVAAGFLRVANENMARPIRALTENRGFRTASHNLSCFGGAGGQHACAIATNLGIHSVLVHKYSSVLSAYGIALAEIGTDMTEPSVEILTTDALPRLAARAEAMRQKATNNLLEQGVKEDKISHTLFYNLRYEGTDTSLMIKHPEDGDFEAAFTARHKREFSFVSKEKRLIVDDIRVTAVGRGEQVESVSWSAELASLRLSPRSPPASPQTTKVYFEELGCFVDADLYDLTQLSPGMVIKGPAIILDDTQTIVVFPCNEATILKDLVYIDIGLGPKSELDTTSVDPIVLSIFGNRFMAIAEQMGRVLQKCATSLQIKERLDFSCAIFSGDGSLVANAPHVPVHLGSMQYAVKGQAELHKGQLRPGDVLVSNHPKMGGTHLPDITVICPVFHREDGVDHLVFFVAARAHHNDIGGLHGNSMPPESEEIWQEGALIYSAFLVRDGVFNTEEIIRYLTEPGQYPDCLPAARPQDNISDLKAQVAACTVGVEQIQLLFNEFGRHVTLFYMEAIRQNAEDVVRSFFKRLAVERGNKPLTAVDHMDDGSPIALTVTINGDDGTAVFDFQGTGHSIHGNINAPPAVCNAAVTYCIRCMIGTNMPLNAGVLAPIDIKIPYNTLLNPSPGVAVSSGNTEVSQRTTDVIFKAFEATAASQGCMNVVMFVRENGHGYGETVCGGSGAGPTWQGTSGVHINMTNTRITDAEILEKTQPCILRQFQLRPNSGGIGRNNGGDGVIREFEFSEAMSVATIGERRVTQPYGMKGGGPGERGAFFFSRKNEKGDYVTIKTKPCCTLKVKPGDRVVLHTPGGGAWGEPSEMSEPQTADDILKVHGFVPRANGSWASYQDAQHASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MNP0</accession>
    <name>A0AAJ8MNP0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Nuclear transport factor 2</fullName>
            <shortName evidence="3">NTF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_102777</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012285.2">
        <property type="nucleotide sequence ID" value="XM_019154882.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MNP0"/>
    <dbReference type="GeneID" id="30171501"/>
    <dbReference type="KEGG" id="kpin:30171501"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00780">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000005">
        <property type="entry name" value="Nuclear transport factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045875">
        <property type="entry name" value="NTF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12612">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="4">
        <location>
            <begin position="7"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00026247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU369002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC68841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="121" mass="13570" checksum="A1F79C3379B2AC37" modified="2024-07-24" version="1">MSDPTAIAQQFTQFYYQQFDTNRNGLGSLYRDTSMLTWENTQIQGSTAITEKLVNLPFEKVSHKIVTIDAQPSSPSTASLIVLVTGQLLVDDGTNPLQFTQVFHLMPEGGSYFVFNDVFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MP33</accession>
    <name>A0AAJ8MP33_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_103199</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058795.1">
        <property type="nucleotide sequence ID" value="XM_070202694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MP33"/>
    <dbReference type="GeneID" id="30170165"/>
    <dbReference type="KEGG" id="kpin:30170165"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF38">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="28"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC69261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="808" mass="91638" checksum="9A5B679D5717581F" modified="2024-07-24" version="1">MAPTVKAVNPPSNLPILPGPSQRKQNLACDSCRKRKVRCLRTEKTQICQQCSNKGEECTNLYIDSLAQAKNKKVRKSSHENIANDMDTVQKAKKRLNSNKKRLISSQNLRLTQMDTEDQSRMHDHEDRRRRNSANTVISTYDPGESSRQGSMTMTRNNSMDSLQQASNVALPDPYIVPQDIVQDPMSFSCHATNIPDLSTLTPDVTQRDMIKYLFAPLAIVNLEYGYNDVSSLSMCKDGKSDLWEEQDGKIWYEQPSEIHKSLDEEAIKDLVDDLIDTFFSIVQPRYTMIDSTLFRERFAMGSNHRLGNISHALLAIVLTYGARFSDHPVLQADGEECSLRDGVHMKNRNRSRLVGLMVIRTREIAERSKIFRVASMENTHSCFLLEHLLGHYQNIYLSAAVKHLITMDLNTSAKWTEIQDNDLRTEALSLLWIVRMSDASRAALYRLKPSLSAEHFDVDPVQHAMLSEGAPMMQPLGGTEHNIIDQATWFKIHHTFCSICYTLAKSLWIPSISARGIPFTILREFIHSSSIWRDKYLSSIGIPTIWPEHWDFLQAITTCTTDCYYHVLWLLIYKAINDFGIKEEKSILEKNDSNKFEIENIKRRIKEEAEHAALRIAALTGVLTENGYLKLDPLIINQPIFLAGEYLASLGKSEYLICVAGLKQYSVIYPSLWDQADLLDQIYSQAKVNIFDQMQTINNENANSLLIGVVNETTTNHPDEGGQLNLNLDLNMGTMNIPPRLDLMSSFEDWTGSLGSIPSFNNQAISQSVHSEGMVNANNSSNQVLEDFETGPIAQKDPLNVEHWLGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MP48</accession>
    <name>A0AAJ8MP48_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Bola-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_103244</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BolA/IbaG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013679.2">
        <property type="nucleotide sequence ID" value="XM_019153518.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MP48"/>
    <dbReference type="GeneID" id="30170119"/>
    <dbReference type="KEGG" id="kpin:30170119"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.90">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052275">
        <property type="entry name" value="Mt_Fe-S_assembly_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46188">
        <property type="entry name" value="BOLA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46188:SF1">
        <property type="entry name" value="BOLA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC69306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="12676" checksum="55CABCD9EF3223EE" modified="2024-07-24" version="1">MFCPRLRSILSTTPSIRQLTISSSSSKILRAYSTPASVPLDKGEQAIYQKLKTALPGKRLEVQDVSGGCGSFYAIEISSPAFKGLSTIKQHKLVNKCLKEDIEGIHGLQLKTIPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MPB9</accession>
    <name>A0AAJ8MPB9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_102850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058736.1">
        <property type="nucleotide sequence ID" value="XM_070202635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MPB9"/>
    <dbReference type="GeneID" id="30171571"/>
    <dbReference type="KEGG" id="kpin:30171571"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC68914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="642" mass="69703" checksum="7E283C20693BBD07" modified="2024-07-24" version="1">MSNKEDVPHPDRPFSPSPPRENRHSASRPPSLLFGAPPVGTVASSSTFSLAGLPSTPPARTEMKSRIFSSRPGDPDHDDFVRKRHSSEVAVRSIPDEARQTVRGRSSSMRFSRQRSDSESSTTSSASPPLGATSILSELANPTPPRGHITPAHSPQVYHGRTRTASEVTSLRTPTLDVPASPKSYQSGFSSSSSTYDQLASSHSLPRLHQPTVVRRTSGRGLAFLPPPAHTVTHSTIVSHHPRSPSSGNTTISHTNHKTASVSRLQDIQHHASLLELGQPLLESTKSRKDERLIAMRGSEEQSMVQPTTLSDIPAPYPPDMTHEVGGNTDTPESESLLNSPEAEYPNAAAAETSDEDPDDHLAANLPTAAIIEEHVPATTPVPDHEAVEDAQSDEACALEPLSNSAEARVSDVAATEEVNHVVEEYPAEDTAGIPPTVCLNQEMPIKAHDPEHEVSENSDAHCSIRSVSPDLHEVATPDVAAQYLNDDLAPPIAKKVMTLPPTHTMTQTTTPLMSAKLQSNDETASKFGQTPKVPYKPRKGSHTFGVKHSPASDDTRQISFYATLNNPANPLPQFTSYRLELALLWGEAHVLRWIPGRKYIPDWNLKVVGGHSKDPVIIDVRVVIKTVVAKLPIFWRFASWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MQN2</accession>
    <name>A0AAJ8MQN2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RecA family profile 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_104065</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058977.1">
        <property type="nucleotide sequence ID" value="XM_070202876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MQN2"/>
    <dbReference type="GeneID" id="30172728"/>
    <dbReference type="KEGG" id="kpin:30172728"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033063">
        <property type="term" value="C:Rad51B-Rad51C-Rad51D-XRCC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:Rad51C-XRCC3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:meiotic DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
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        <property type="entry name" value="HR_Repair_Mediator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3 RAD51C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13481">
        <property type="entry name" value="AAA_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="Rad51 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="7">
        <location>
            <begin position="130"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC70118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="432" mass="47275" checksum="D716AEF980F514EC" modified="2024-07-24" version="1">MVHLNPLSLKTTTLLFTYTFLAFTFIEDELNTMIQSQAQAIALLDIPRSLRESLHDAGYITIDDIGSSSASDLSAELGISRNQAEDLLQQISSLQAGVSTSSKAGSDSTQIPLQSQIQASTAADLLSSAYLPHFSTCSTSIDRLIAQFHVPHRRKANTGVFRKGKEKEDSGAITPGMTIEIAGPPGIGKTAMALGVVLSARLTSAGISDEKEMEAGEVLILDTEGGITAERVRSAAEALTRTRATLPRDIIHGIHFVRIPTQTHMVAFLHTLDEWLENYPKVNLIVIDTLSFHFRQPSLDMSTRRRMMDLVKQKIGQATTLHKCAVIICNQMATKLLTAENKPANFDTGDRAILMPQLGDSWTTGKTLRLCLFRGQGGDELRYVHAEMSGSSKGLKWAAFDIDDDGLPCDIPEMLYDRPKTPPFIGETELNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MSA5</accession>
    <name>A0AAJ8MSA5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Telomere length regulation protein conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_106009</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TEL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059327.1">
        <property type="nucleotide sequence ID" value="XM_070203226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MSA5"/>
    <dbReference type="GeneID" id="30173201"/>
    <dbReference type="KEGG" id="kpin:30173201"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.720">
        <property type="entry name" value="Telomere length regulation protein 2, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038528">
        <property type="entry name" value="TEL2_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051970">
        <property type="entry name" value="TEL2_Regulation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019337">
        <property type="entry name" value="Telomere_length_regulation_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15830">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15830:SF10">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10193">
        <property type="entry name" value="Telomere_reg-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Telomere length regulation protein conserved" evidence="3">
        <location>
            <begin position="691"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="595"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="595"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="653"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC72049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1132" mass="125144" checksum="C7F506F57A11827C" modified="2024-07-24" version="1">MTSSSSSDMLLALKGLRDTLRNPTVLTPDDLSFQLSSTLEALHIHPNSVTPSSISKENLKGISRYFPTIQGILLNEIIPSFYEVLDDKAQLNLRTFFVPPKSSDGLALRRQIAIVSYTTLPTFLNAPKPGQAGLLKSTRRFLIDILGELVNTYNIDDLYFAIHSQHIENDEKGKGKDMEGRNALQWEEALRSCIGIPAKIGNSVGRWNSENQFITDLPKILEPKIYFDKMISRLEDLMYELSQRALSIDPTPIRLVFEKLCSIGLVNAAPSSSDSRSPSLFPALLPPLLKHIRPPSESSLLPYPAEYLPSVLLGLPSSILASFVESLLSHLTFHPIDPTNPLRSNKPDQRIQRCLEVFTRIVGKPKQGEEAWNAVIRSVLSGKDELTLNDNKSQARNRLIVAWIATGGENAVKSFIETVIDAWTDPKYVKFALYAKQLNLTHVLLLSFSYVIPFTPWLVSLSHRSRLIISFQAYLSHPDASIRRLGMLVAEILSELTIPESDSSEPQIGIDEEIEDLRKGLEDINGNDGKAQKSQKKSSGDMKRLKFSGIWEGKGQGREECQWLRSSMGIRDNAAPLEDESVDEDWLLGWIETSSTHSSAPAPTATSSLSAVSRGRPNTREKPKSLKGKTKVQPKIVMLDPDQLDDPMQGYESSSPSSSRSPSPTPSYLEEVTADPSLALDATQKKKIIRPVYIPQLVALLKERDKPENIEMGLKWGESLIRAKREFGTELSENAVAVTLMTLGLNDPFNLEGFEEKRQGIMNALVACSPQQVAPFLCEQYFNTQYSLQQKSVILTALAMGARELAGLSIPEPTTKKIDFPSKTLPPTLHKKYLTLVDIPQSRRQAIEDTPTNGQLENTISNMRNGLLSKGARKGDDVPDLARERRLKVRNKSQKAYVAELGSLKDSQMLSNLPTKQKIKPVMEFKDIAAENFILPMINRFWLYYNDYNLQQSRSNSLLGSKAGYGGTGGGMILTPLGLEKFLITLSILLNASRHSSIFLSVLAPETLELALTLGIRFSSTNKINSIGGSDIQQEEENGESLVISSSLELILVILDISFELDKGRSLFLDKSELVLGIGEFATTIFQNEISGNEISGGQGGLTSEGRIKAIAAATVLKVGEIGEKWGGLSMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MSD4</accession>
    <name>A0AAJ8MSD4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thiamin pyrophosphokinase thiamin-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_106099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059341.1">
        <property type="nucleotide sequence ID" value="XM_070203240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MSD4"/>
    <dbReference type="GeneID" id="30173291"/>
    <dbReference type="KEGG" id="kpin:30173291"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030975">
        <property type="term" value="F:thiamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.320:FF:000001">
        <property type="entry name" value="Thiamine pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.320">
        <property type="entry name" value="Thiamin pyrophosphokinase, thiamin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007373">
        <property type="entry name" value="Thiamin_PyroPKinase_B1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036371">
        <property type="entry name" value="TPK_B1-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04265">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00983">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63862">
        <property type="entry name" value="Thiamin pyrophosphokinase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiamin pyrophosphokinase thiamin-binding" evidence="1">
        <location>
            <begin position="26"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC72139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="95" mass="10710" checksum="1A33A66945757BCB" modified="2024-07-24" version="1">MSLLHKLKREIYVLDGESFAWLLREGKHEIQIDHNTMGQTCGILPVGVDSSRVITKGLKWDFGDVSTSNHLVPSIPLITIETSRPVLWTCEIKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MT86</accession>
    <name>A0AAJ8MT86_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_106524</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059436.1">
        <property type="nucleotide sequence ID" value="XM_070203335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MT86"/>
    <dbReference type="GeneID" id="30176281"/>
    <dbReference type="KEGG" id="kpin:30176281"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="671"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="671"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="700"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="755"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC72562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="775" mass="86188" checksum="E45E93A2A1542259" modified="2024-07-24" version="1">MNTFISASSPLFRYQPCKSCEVTQGFQSGSDFSGRDYNGTESGMITRTAGTSVSMNCTGTGISFDISYSSPNNSSFKPFLRINGSSPSTSQNATSTSIRGLPLAQHTFELDILSSHDSSDTNNNTVPNDWIRINGATCNLGYAINSQTKNETIDDTAWRDWKIYLTPGWNMLEKDVSNYIDLDQYQAELPTSSRNYNNSISWTEQSNAANQIFFAASAVWVYGIVGDQAGSFEVILDNTAQGVFDGSGGPRVYNSILYHASNLLDTNHTIMLRNIEEGKRLSIDRLISMSGLTPLTNTLPSSPPSPSASQTMSSVEVSSYYPSSTAPAAEQLGLPTSLSGEAIAGIVVAASIVLIAFMITWIFACLRKRKEHKINQETESRRSEGLDNEKAQTTFFRFSSRASSPNRPHPFHPLPSPKNLLQEPQATIQSSIPQQQNNTNSFLKINNSRFSRSTNNQQSEIISDLPTTSENDLGHIPKKSISGLNISNPQPITIQRKNSEDYLPSLSSASSQIQPLNPKKSSEKLNPKHKHKHEHEHELTTAPVESRINTSQLLHNNRFETNQSDSNVESIRRETKPPLVAALSGKTSSPLTELSKSTFISKKNSKPFNFEEKNYFGRKSKQSLNNERKSISNSLKTVKTNYTNYTDEENGILSMYAKFPTGIERQSKRNTQFQFQENEQQQQREEDNLSGVGVALGSPMQDNNFQWTNNEPVPQNSNNDITKFNRNNNDNEEEEEEEFKPPTRRFFGLGDRPKSGVSNKSGKTVSSVGSGWRYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HSD6</accession>
    <name>A0A1B9HSD6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Copper acquisition factor BIM1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_07828</name>
        <name evidence="12" type="ORF">I206_100013</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
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                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="Dromer F."/>
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                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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                <person name="Heitman J."/>
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                <person name="Litvintseva A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
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                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
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                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV700118">
        <property type="protein sequence ID" value="OCF46262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC69847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007481.1">
        <property type="nucleotide sequence ID" value="XM_019159429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HSL4"/>
    <dbReference type="STRING" id="1296096.A0A1B9HSL4"/>
    <dbReference type="GeneID" id="30176108"/>
    <dbReference type="KEGG" id="kpin:30176108"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
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        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Related to multidrug resistance proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
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    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
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    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
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    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF78">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="18"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="305"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="338"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="361"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="396"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="480"/>
            <end position="499"/>
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    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="21"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF46262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC69847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="548" mass="58738" checksum="F5E79FCE5BCF50C1" modified="2016-11-02" version="1">MGLVTMEDQATRLPKSKLILLCFGLQIALFLSFIDSTSVSTILPIVGSDLNATNSITWAGTAFLVANTSFQIITSRLSDCFGRKIVLMGSLSLFAIGDLLAGFARNKVWLYCARAVAGIGGGGINSLSMIIMSDVVTLRERGQYQSLLGIGIAMGSGVGPFLGAVLAEKVTWRWTFWIIAPLSALTMLLIQYTVPLKPVGGELKHKLAKMDWIGSILSLAMTICILVPLSGGGSTFAWNSPIVISLFVVGGLSVIAFIVVERYFAAFPLFPGRLLLNRNVCLLLVQTWLVGMVYYGGIFFVPLYLQNVQDYSPILSAALLLPLVLGQVLTTTISGYVVKFTNRTWASFFVGFVLWTAGQGAQLCFGKSTTKGVIIGCLILQGFGIGSTIQSTLVLAQASGLSGDRAVITGVRNFARTSGGAIGLAIGNSILQNVFLGHLPEDLPQNDVKQLADDFGHIKQLSETMAAAVREAYMQGIRKVFIFFVPVVAICLFMCTFIKDLPLDTPSIPILPTENSKEPSPECLIGPSESDGSSEDKVQVSETSKTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HT31</accession>
    <name>A0A1B9HT31_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_07663</name>
        <name evidence="8" type="ORF">I206_102293</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI894017">
        <property type="protein sequence ID" value="OCF46429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="WWC68368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_019159354.1"/>
    </dbReference>
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    <dbReference type="STRING" id="1296096.A0A1B9HT31"/>
    <dbReference type="GeneID" id="30176032"/>
    <dbReference type="KEGG" id="kpin:30176032"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF15">
        <property type="entry name" value="GENERAL AMINO ACID PERMEASE AGP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="374"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="6">
        <location>
            <begin position="48"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCF46429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC68368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="549" mass="60808" checksum="C2159AFC5F5C8C76" modified="2016-11-02" version="1">MDPVKMQEDDKSEAYIGTHEVDNNNVDYDMAGAVAHSVNHRRLNPRQIQLSAIAGSIGAALFVAIGSGVLSGPLCLLIAFIFWATVVWSIAQCQMEIVTVFPLDGSFIRLAGRMVDPSLGVMAGWNHFFAQTSYIIFEATIINTLVEYWGYDKNPAILITVSLILYLAINVYRADLFGEVEFWLALGKVLLALGLIAYTFVTMVGGNPLHDRFGFRHWKNPGPWAGDSPSTRLESFVNAVNVAGFIMGGPEYISMIAGEAKDPRRTVPRAFRTLMARLIIFFIGGCLCVGVLVPYNDETLTLGKSKTYAGKSPYVISMTRLQIPVLPSIVNAALITCVLSAGNAYTFNASRSLHALALEKRAPRFLTKVNSKGTPYWSVIVVIILSTLAYLALGSGSAKVLNWILNFCTAATMLNWTIMAITWIRFNKAMKVQGIDRKTFLPVVSKLQPYAGYWACFWAPLFLFLQGYAVFLRGNWDIATFIFNYGIIALAGGIAIGFKIFQKLPFHKSKDVDLHSDLEFFDALNDHYQQVKDDNPPSNIKEKILAKVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HT38</accession>
    <name>A0A1B9HT38_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phytanoyl-CoA dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_07664</name>
        <name evidence="9" type="ORF">I206_102294</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PhyH family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894017">
        <property type="protein sequence ID" value="OCF46430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007649.1">
        <property type="nucleotide sequence ID" value="XM_019159355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HT38"/>
    <dbReference type="STRING" id="1296096.A0A1B9HT38"/>
    <dbReference type="GeneID" id="30176033"/>
    <dbReference type="KEGG" id="kpin:30176033"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF45">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF46430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC68369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="317" mass="35236" checksum="39A21DB82A319449" modified="2016-11-02" version="1">MTVQPPQKLVTIDASEPLEKIYEIIARDGGVIVSNMLSPPLLQELMGAIEPHFENRNEYKSKATHEELGADFFPEGSKRVYALLSKIPEQLTKIMRLQVWQGIMGKFLNDEYYSYTGENHLSQKSGFMLASTAALRLVPGAKPQPLHRDQIAYMVRPDPSNPLFTPMVGCLIAGSKCTYKNGATAVIPGSHLWGPDRIPEKSECTYAEMEPGSALFTLGSTYHAAGENISEPTDPEALRTLFAVFGQRDYYRQDQEEILSTPIEIARKLPEDILKLAGYHKAVGGVGYVEDHQSPHEFLHTEYGLGKFVPQAIKNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HTE6</accession>
    <name>A0A1B9HTE6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aspartate aminotransferase</fullName>
            <ecNumber evidence="8">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_07391</name>
        <name evidence="11" type="ORF">I206_106720</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="8"/>
    <dbReference type="EMBL" id="KI894016">
        <property type="protein sequence ID" value="OCF46538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007757.1">
        <property type="nucleotide sequence ID" value="XM_019159085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HTE6"/>
    <dbReference type="STRING" id="1296096.A0A1B9HTE6"/>
    <dbReference type="GeneID" id="30175760"/>
    <dbReference type="KEGG" id="kpin:30175760"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006533">
        <property type="term" value="P:L-aspartate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000026">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF22">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 10" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="9">
        <location>
            <begin position="54"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF46538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC72756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="429" mass="47137" checksum="38FBD648FA45CB34" modified="2016-11-02" version="1">MLTQTSRLLLARTPRTTVLPVARAAASTWANVPAGPPDPILGVTEKFKADKSPKKINLGVGAYRDGQGKPYVLPTVKKAEKILSDAMQDKEYLPITGLAEFTKLAAELAYGKDSKPIVEKRLAITQSISGTGALRIGTAFLARHYPGAKTIYLPTPTWGNHIPISKDSGLEVKQYKYFNKDTVGLDFEGMKADIKAAPEGSIILLHACAHNPTGIDPTEAQWKELSDLVKEKKHFAFFDMAYQGFASGDILKDAFAVRYFVEQGHQILLCQSFAKNMGLYGERAGAISFVCESAEEKARVDSQLKILIRPLYSNPPVHGARLVSTILSSPELTEEWLIEVKGMADRIIEMRERLYNKLVELKTPGEWGHIKSQIGMFSFTGLKAEQVDALAEKASIYLTRDGRISMAGLNANNVDYFAESVSKAVKGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HTG0</accession>
    <name>A0A1B9HTG0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-rRNA-processing protein PNO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Pre-rRNA-processing protein pno1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_07403</name>
        <name evidence="10" type="ORF">I206_106708</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PNO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894016">
        <property type="protein sequence ID" value="OCF46550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007769.1">
        <property type="nucleotide sequence ID" value="XM_019159097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HTG0"/>
    <dbReference type="STRING" id="1296096.A0A1B9HTG0"/>
    <dbReference type="GeneID" id="30175772"/>
    <dbReference type="KEGG" id="kpin:30175772"/>
    <dbReference type="OrthoDB" id="1932641at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22391">
        <property type="entry name" value="KH-I_PNO1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22392">
        <property type="entry name" value="KH-I_PNO1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000009">
        <property type="entry name" value="RNA-binding protein PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055212">
        <property type="entry name" value="KH-I_PNO1_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055211">
        <property type="entry name" value="KH_PNO1_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826">
        <property type="entry name" value="RIBONUCLEASE Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF13">
        <property type="entry name" value="RNA-BINDING PROTEIN PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22891">
        <property type="entry name" value="KH_PNO1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PNO1 second type I KH" evidence="8">
        <location>
            <begin position="178"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00071744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCF46550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC72744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="268" mass="29382" checksum="5C175D61C2B95D7E" modified="2016-11-02" version="1">MAHKSHRQKALQAQLEAQPTLSLVSSKTKKPSKVSESMDVDDDEILIASSSSSSSNVIQQNTTTTINGESSGSGFKPLPQSQTNGVLKGEFRRIPIPPHRMTPLKKEWVNLYTPMVDMLGLQVRMNTMRRSVELKTSGHTVDTGAIQKGADFVKAFSLGFEVNDALALLRLDDLYLDSFEIKDVKTLHGDHLSRAIGRIAGEGGKVKFSIENASRTRIVLADTHIHILGSVQNIKIARDAIVSLILGSPPGKVYAHLKMVGARMKQRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HTS0</accession>
    <name>A0A1B9HTS0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosome biogenesis ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_07520</name>
        <name evidence="8" type="ORF">I206_106589</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894016">
        <property type="protein sequence ID" value="OCF46666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007885.1">
        <property type="nucleotide sequence ID" value="XM_019159213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HTS0"/>
    <dbReference type="STRING" id="1296096.A0A1B9HTS0"/>
    <dbReference type="GeneID" id="30175889"/>
    <dbReference type="KEGG" id="kpin:30175889"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990275">
        <property type="term" value="F:preribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19530">
        <property type="entry name" value="RecA-like_NVL_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000018">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000365">
        <property type="entry name" value="Ribosome biogenesis ATPase RIX7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="151"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="486"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="746"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCF46666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC72626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="790" mass="86205" checksum="1D6F718AF8D19940" modified="2016-11-02" version="1">MSGIPSLNSSITSAWATTSSSSNSIQPKKRVKRSLGLNNASASSSNAPSPTSQSQSQSQIQPLAESSTSTLTIQQQQQQNQNQIPEEKIATPSIRRKRPKNDPESLQAKYAPPNLKLSLLGGLKSQITQLMEIVVLPLLHPEIYQYTGVPKPRGVLLHGVPGGGKTQLVKCLAGELGLPFINVSAPSIVSGMSGESEKTLRDTFDEAKKIAPCLLFLDEVDAITPKRETAQREMERRIVAQLLTCMDDLATSEESVVIIGATNRPDSLDPALRRAGRFDHEIEMGVPSQEGREEILRVLCSNLRLSGDVDFRWLAKSTPGYIGADLTALTTEAGVIAVKRIFEEMSSISNLASTISDVPSDGVAEETNGIEQMIIDDGLTISNLDPNAPFLTLPEDIRQTAIAKFLISHPNPLNESQLENIKLKPEDFLKALKIVQPSAKREGFATIPDVTWNDIGALSTVRDELHMAIVQPIRHPELFSTVGIDAPSGVLLWGPPGCGKTLLAKAVANESRANFISVKGPELLNKYVGESEKAVRQVFMRARASSPCVIFFDELDALVPRRDDSMSESSARVVNTLLTELDGLDSRKAVYVIGATNRPDMIDPAMVRPGRLDKLLYVDLPSPEERFEILKTHTSRTPIDTNSWNSIKDILIGEKCDGFSGADIAALVREAATLALRSALESLGAFEVPLENDPTINGIFKDENKKEKKEIIVTEEHFKKAAIKTLPSVSKEQRIKYERMRDKYAGLPTKGKRSREGGLINEGDLLSGNIREEKRSNKGNGEGDAEMSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HUL4</accession>
    <name>A0A1B9HUL4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_06733</name>
        <name evidence="3" type="ORF">I206_102172</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700117">
        <property type="protein sequence ID" value="OCF46959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC68249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008178.1">
        <property type="nucleotide sequence ID" value="XM_019158432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HUL4"/>
    <dbReference type="GeneID" id="30175102"/>
    <dbReference type="KEGG" id="kpin:30175102"/>
    <dbReference type="OrthoDB" id="2589163at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF46959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC68249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="474" mass="52584" checksum="167B5318C458D9E3" modified="2016-11-02" version="1">MSHPHNLPPIGQAPQQQIHSLNNTRRASSTSTRQHHHNHNDYSDSESDGEDDKVEKDKLEIRREKNRVKQRNLRLRRANHIAELEKNLANFRADQSILQNNITHLQARENSLQGWIHDLESALFRNGLAGEVETLRRIWSDKNTSIPQTQHQIRPKSQHGFSQQPPLPTPAANAPLVDPLSTLARAASSIPPGVPSSGRMSYPSSSATGSRPTLPQPISSSRPFENPYPTPELHWGSQMSEWVPAPSEMEKKRKRDSQSEYTQARPVLHPMSGRLSESNVHTLPPIQSYRSGSPSSARPTSAPYQSKTSAPISASTSGTGNISPRSIRISDLVSPRPFDVESGLPSLSRELSGSDHSYRQSDMLTAKENGWNRISRGASSPDKDTNGLSQSRPNKLAPIRFFQSKEDRVYPISTPSSPKTLSPNHSLIKMEREEVSPKTRNSLSPTALRAGMNRSPLLQVKENPLLDGQIPKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HUL7</accession>
    <name>A0A1B9HUL7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF4048 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_06734</name>
        <name evidence="4" type="ORF">I206_102171</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
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    <reference evidence="14" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the COP9 signalosome (CSN) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family. CSN5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV700117">
        <property type="protein sequence ID" value="OCF47019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC68191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008238.1">
        <property type="nucleotide sequence ID" value="XM_019158492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HUS7"/>
    <dbReference type="STRING" id="1296096.A0A1B9HUS7"/>
    <dbReference type="GeneID" id="30175162"/>
    <dbReference type="KEGG" id="kpin:30175162"/>
    <dbReference type="OrthoDB" id="605656at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000003">
        <property type="entry name" value="COP9 signalosome complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040961">
        <property type="entry name" value="CSN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18323">
        <property type="entry name" value="CSN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="12">
        <location>
            <begin position="51"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="278"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCF47019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WWC68191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="363" mass="39948" checksum="50837BF8CEA0AD56" modified="2016-11-02" version="1">MATIAMKTFELNNQVQSVDPTTAIFQYSREDEKSLEDAAPWSQDPHYFHTVKISAVALIKMVTHARSGGAYEIMGVMYGRVRDGVFWIMDAAALPVQGTETRVNAGNEAMEYMVSFQESSREAGKGELLRGWYHSHPGYGCWLSGIDVNTQQNQQKFNDPYLAVVIDPNRTVSAGKVEIGAFRTYPEGYKPPSSGASQYQSIPMDKIEDFGVHADAYYPLKVEIYKTKLDEELLDLLWNKYWVATLSSSLLTSNREYSTSQIKDLNAKLQGASAGLGSSSTNLKLKAPPPSQSGSKGKANSREYAGVEEEDTALAKAAKDSSRIATEAQNGMVAQLLKDRLFNTPLSGELTRDAARATVQGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HUX9</accession>
    <name>A0A1B9HUX9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial</fullName>
            <ecNumber evidence="5">1.1.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Isocitric dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">NAD(+)-specific ICDH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I206_06848</name>
        <name evidence="14" type="ORF">I206_102059</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:23632"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.41"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Octamer of two non-identical subunits IDH1 and IDH2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.41" evidence="5"/>
    <dbReference type="EMBL" id="KV700117">
        <property type="protein sequence ID" value="OCF47074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC68136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008293.1">
        <property type="nucleotide sequence ID" value="XM_019158547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HUX9"/>
    <dbReference type="STRING" id="1296096.A0A1B9HUX9"/>
    <dbReference type="GeneID" id="30175217"/>
    <dbReference type="KEGG" id="kpin:30175217"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000001">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF42">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="12">
        <location>
            <begin position="48"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCF47074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WWC68136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="380" mass="41286" checksum="032C7026CBFC4549" modified="2016-11-02" version="1">MISAPLRSSVGSALRSAAASSKRATVSRSMATLVDEKRLPAKFGGKYTVTLVPGDGIGKEVADSVKEIFEALKVPVQWEQYDVSGETVGGDDLFQQAMESLKRNKVGLKGILYTPIDQTGHNSWNVAMRQQLDIYASVVVCKSLPGFPTRHDNVDFAIIRENTEGEYSGLEHQSYPGVVESLKVSTRAKAERIARFAFDFAVKNNRKKVTCVHKANIMKLGDGLFLNTCRRVAEQEYGHTGIKFEAMIVDNTAMQLVSRPQQFDVMVMPNLYGTICANIGSALVGGPGITPGCNFGREYALFEPGCRHVGKDIMGTNKANPTALILSSTMMLRHLGLESQANLIAGATYDLVKEGKIRTADLGGSATTTDFTKGLIQRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HVC7</accession>
    <name>A0A1B9HVC7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcription factor Pcc1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_06994</name>
        <name evidence="9" type="ORF">I206_101915</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTAG/PCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700117">
        <property type="protein sequence ID" value="OCF47216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008435.1">
        <property type="nucleotide sequence ID" value="XM_019158689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HVC7"/>
    <dbReference type="STRING" id="1296096.A0A1B9HVC7"/>
    <dbReference type="GeneID" id="30175363"/>
    <dbReference type="KEGG" id="kpin:30175363"/>
    <dbReference type="OrthoDB" id="10025739at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000005">
        <property type="entry name" value="L antigen family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015419">
        <property type="entry name" value="CTAG/Pcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283">
        <property type="entry name" value="EKC/KEOPS COMPLEX SUBUNIT PCC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283:SF5">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT LAGE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09341">
        <property type="entry name" value="Pcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="97"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF47216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC67996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="16118" checksum="D1132FBC7E6C7D94" modified="2016-11-02" version="1">MQNENQTQAQAGPSREGWHKTTIRIPFYTSQHAQIAKQALEVDKEQNGSFVHRELLTEGDILIANYETTTVRLLRLSTNSFLSSLDLVIRTMTSFASDPNDKFISDEELEKNKEEANQSAGGSKEGIELKGDGRGAGSGEEVKSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HWP9</accession>
    <name>A0A1B9HWP9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">LEM-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_06573</name>
        <name evidence="11" type="ORF">I206_101455</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008887.1">
        <property type="nucleotide sequence ID" value="XM_019158274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HWP9"/>
    <dbReference type="STRING" id="1296096.A0A1B9HWP9"/>
    <dbReference type="GeneID" id="30174942"/>
    <dbReference type="KEGG" id="kpin:30174942"/>
    <dbReference type="OrthoDB" id="5376590at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071763">
        <property type="term" value="P:nuclear membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12935">
        <property type="entry name" value="LEM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1180">
        <property type="entry name" value="MAN1, winged-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025856">
        <property type="entry name" value="HeH/LEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044780">
        <property type="entry name" value="Heh2/Src1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018996">
        <property type="entry name" value="Man1/Src1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041885">
        <property type="entry name" value="MAN1_winged_helix_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47808">
        <property type="entry name" value="INNER NUCLEAR MEMBRANE PROTEIN HEH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47808:SF2">
        <property type="entry name" value="LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12949">
        <property type="entry name" value="HeH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09402">
        <property type="entry name" value="MSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HWU4</accession>
    <name>A0A1B9HWU4_9TREE</name>
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        <submittedName>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">CBS 10737</strain>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
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                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
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                <person name="Goldberg J."/>
                <person name="Griggs A."/>
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                <person name="Imamovic A."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
    <reference evidence="2" key="3">
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
        </source>
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    </evidence>
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            <dbReference type="EMBL" id="OCF47730.1"/>
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    </evidence>
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            <dbReference type="EMBL" id="WWC67486.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HWV7</accession>
    <name>A0A1B9HWV7_9TREE</name>
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        <recommendedName>
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    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
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                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Chapman S.B."/>
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                <person name="Saif S."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
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        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="7">
        <location>
            <begin position="30"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF47755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC67461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="200" mass="22194" checksum="F82E96E8C11F2B59" modified="2016-11-02" version="1">MPPINGISTPSHGSRPGSTKPGTPISNTSNSSLILRKQLLDLQKSPVDGFSAGLVDDDNILEWQIVIMGPADTLYEGAILKARLIFPPEFPLQPPRMIFDSEMWHPNVYNNSDKRGEVCVSILHQPGEDEWGYEDAGERWLPVHTVESVLISVISLLSQDVPDLNSPANVDAAKEVREDFASYKKKVKRLARRSAEEAYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HXQ1</accession>
    <name>A0A1B9HXQ1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_05898</name>
        <name evidence="4" type="ORF">I206_107565</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894014">
        <property type="protein sequence ID" value="OCF48031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC73593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009250.1">
        <property type="nucleotide sequence ID" value="XM_019157610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HXQ1"/>
    <dbReference type="STRING" id="1296096.A0A1B9HXQ1"/>
    <dbReference type="GeneID" id="30174267"/>
    <dbReference type="KEGG" id="kpin:30174267"/>
    <dbReference type="OrthoDB" id="78947at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0047134">
        <property type="term" value="F:protein-disulfide reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045108">
        <property type="entry name" value="TXNDC17-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010357">
        <property type="entry name" value="TXNDC17_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452">
        <property type="entry name" value="42-9-9 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452:SF0">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06110">
        <property type="entry name" value="TXD17-like_Trx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF48031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC73593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="122" mass="13949" checksum="DDEF76D73FE767A4" modified="2016-11-02" version="1">MPLTISGKYPPFESFLKTQNDKPTFLIFYSDIENGKMWCPHCRDVEGIIKSNFEGKSKPNGIITYIGPYSGWKNVPSHPARLKYGVRFVPTIIKLDNNGKEIDRVEKPGILDSTRLEEFLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HXV7</accession>
    <name>A0A1B9HXV7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nuclear protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_05957</name>
        <name evidence="7" type="ORF">I206_107624</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI894014">
        <property type="protein sequence ID" value="OCF48090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009309.1">
        <property type="nucleotide sequence ID" value="XM_019157669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HXV7"/>
    <dbReference type="STRING" id="1296096.A0A1B9HXV7"/>
    <dbReference type="GeneID" id="30174326"/>
    <dbReference type="KEGG" id="kpin:30174326"/>
    <dbReference type="OrthoDB" id="4934715at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF87">
        <property type="entry name" value="COL-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="106"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="701"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="759"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="7"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="844"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="865"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="891"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCF48090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC73652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1046" mass="114926" checksum="A2CCBB825A3EC9F6" modified="2016-11-02" version="1">MSQPPVLQSSLSNHSLSSFTATNPNPSSNNPSNNANTNASSSNSRPAGSSSTTTNNKKRKASSPGPIAKERKQSVPIDPSTDDDAASTVSRTNRDREPKRTRVHFSCVECHRRKQKCDRKEPCSQCVARRVPHLCRPFLNGVEDPNSNSDVHARLNTIESLLSRLVTSLPQTLTSRSNGNYVPTDASSPDVLTLTASGEDQFHPHAAPNNNDSPIARVNMPHKPPPSGLFPSNMSYSIPPGRTGFGWGLREGRRISLTTEDNQDLRDILQTLKESGIGKSHLEWLIAGVPGRRMADGLVELYFRWTRYKMNKASFMRRYNKFFDHIGRNPTCPKVDADTLKWLPLMFIVLAIATLSATHELVPRDDQSGWSRRFYGSARSGLEYAKALQRDNLDVLFAGLLASRYMLLTRRPAEGSTPLTTAFQVGLYRDGTVLNITDKKEIEIRRRAWSMLYHLDRTISLLVGRPASISDAHTDTQIPANLDDEEVESGDFDPAGHPLTKPTQYTYVIVRHRLAEIMGRIAYHTFTIQLPDYANVLNLDRELLSWRDALPPFFSMSNPDTSLDAKFPYLFVQRHLLASEWYYTRITLNRPYLLRRKPQDGRYSYSKSAAIESARADLLGRRSFVMEKGNLIVNSGGYRVLNSYMVLGVTIKLDPDSPQADELRQLLNVVSGRSSDAQGRISEPLVKEELAIVEFLTAKPQSNKSRGPVPATGNSGNKDEDQTPVDLLLGLAKTRSGRRAAEEEKRQLRLQAYREVEEQRQAARRNSGAQNISSPWGYIAPSMPGLDVQQPFGGSADKRVPRPLQPPQPARRADGSIPDSTNWSPEMAFNFSGNSGSGGAQGRRPSSSGQIGYNINSPTHSLIASSTNSTNNDHQQQQQNGGHGSLISPFGNLNNNNNGMGLNSPNDLNQGIISDGFSFPEQSQSSNAFVGEGMGNDPNGGNQFRNALLDSFDFSDLGLSSTSSNNNNNNNNYGNGLNNNIGGGNGVVGGGFNLNLDLGLGGSGGFNPFALPQTEEGSEPTMAEDDQTIFLNYILNKFANAQPDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HYF9</accession>
    <name>A0A1B9HYF9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_06191</name>
        <name evidence="11" type="ORF">I206_107860</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI894014">
        <property type="protein sequence ID" value="OCF48323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009542.1">
        <property type="nucleotide sequence ID" value="XM_019157902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HYF9"/>
    <dbReference type="GeneID" id="30174560"/>
    <dbReference type="KEGG" id="kpin:30174560"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000171">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF12">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01740)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="416"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="480"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="65"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF48323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC73888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="530" mass="58226" checksum="F5A95DC68B2C2AFA" modified="2016-11-02" version="1">MTSEHQSPKSESTLPNTLPNEKIIPATTSEDETVIDGVDPVYAAKARVLNRAIQDIGMGKYQWQLFFVIGFGWAQDNLWPIVTSLILTPINNEFHPSHAPLLTLSQNIGLLAGAIFWGFGCDIFGRKWGFNLTLGVTSVFGMLASSSPNFAAIGVFAALWSFGVGGNLPVDSAIFLEFLPQSHQYLLTILSVFWAFAQLLASLIAWPILGNLTCQQTDTDCTRSKNMGWRYFVITMGGLALVMFFIRFFVFHIYESPKYFMGKGRDEDAVRIVHEVARRNGKESSLTIEDLRSCETLSGNPQENSIDHKQDSNAKKAIRRKLEQVNGKHIRSLFATKKLAFSTSMIMVVWAFIGLAFPLYNAFIPFTLATKGAEFGDSSTYITYRNACIIAVLGVPGAVLGGILVEVRWIGRKGTLSLSTLLTGIFIYGSTTAKNSNSLLAWNCMYSFFSNVMYAVLYAYTPEIFPTKDRGTGNALTATANRVFGIMAPLIAIFANLETAAPVYTSGALFIAAALVVLILPYESRGKASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HYI2</accession>
    <name>A0A1B9HYI2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2',3'-cyclic-nucleotide 3'-phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_06194</name>
        <name evidence="2" type="ORF">I206_107863</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:RNA processing"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="1">
        <location>
            <begin position="25"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF48452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC73259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="290" mass="32970" checksum="590EE1ADAD7A2F6A" modified="2016-11-02" version="1">MSEQIPTSALVLLESNFVYPPLPPITDPKLKKAVFTHRSLVNSLPSDLQIDWESYDKSAHVGDSLLDTFITCLLHAMYPTARPKVATDLRSKLVNREINSHISRYYDLPSKVKTSKGTSGTFQLSNDEVGEVYEAYLAGLFYSYLNLKSLTSNDEIDFIGYGKAFEKLSNFLILIYKPLIKSLYDDRINKFDYLIEISEGSKSELNTFTQKFKISQPQYGNPELIWPYWIPENERKGNYGKVWQNTCTVFKKDGTMITCTGMAEGTRVTAENVAAYLVLQQLKGQGRNTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HZ18</accession>
    <name>A0A1B9HZ18_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_05295</name>
        <name evidence="9" type="ORF">I206_107160</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC73194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009735.1">
        <property type="nucleotide sequence ID" value="XM_019157017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HZ18"/>
    <dbReference type="STRING" id="1296096.A0A1B9HZ18"/>
    <dbReference type="GeneID" id="30173664"/>
    <dbReference type="KEGG" id="kpin:30173664"/>
    <dbReference type="OrthoDB" id="5977743at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000103">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.18, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033308">
        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315">
        <property type="entry name" value="METALLO PHOSPHOESTERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315:SF4">
        <property type="entry name" value="METALLOPHOSPHOESTERASE, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="719"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="7">
        <location>
            <begin position="84"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="439"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="540"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="439"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="487"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="550"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF48516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC73194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="740" mass="81734" checksum="58432C60227FE7CA" modified="2016-11-02" version="1">MLDSPRIRSPSLGPPNEKGLIGNGKRRSGLKSRGTQLLALRFGWVVLIIWFEVGDFFHSLSTCRFPDSILRRSNPHLKEAPTHVVLLADPHVPHPVLSYAEGSRPWINWLKQQIDELFMRKSWNVVTRLGRIDAVIVLGDMLDCGRGVMTDTEYDDYHNLFRSIFQLPANVPMHFVPGNHDIPLGPNRLFSPHARDRYATHFSKPNTILPIANHSLIMLDAVGLVEEDYRRYAAEMQFGEWDGVEGGVIEFVKDLSENPLPGPSILISHIPLARPEASTCGPLRERGRILKGAGPGYQNLLGSETSRFLLEGLKPSIVFSGDDHDYCEHKHPQGIKEVTIKSFSSSTGIRRPGFQLLSLVPPHPNGYAGSQTLADRPCLLPDQSGVYYRVYIPLAILTLLYLFGTNIRSAWQRWSGSNSTNGAGMYGDLKSRLSPALLSSETMPSNQNNLSTRRGVSDRPVPLTLPSRKSSQQLQGLGTSTARRFTSNPSSDALSSLSRMPSASAPVSPFASPRMSFVDERPALSNFSSGLGTMNEDVEMGSGARQTYDPSSPTPSVSRRSSYIYMNDKPQYQQQQQSLIETPSENHNQSYFLPLPNTSTSQPAGLGFTTPLGSSFPLSAGNSQTLRRVSSSTFSLASHSQGQQGNLISPAPIRRVTMPRMLSTTDWSTAASKKDQSLFNYALNTSKGGAGGLWITAKRFLVWLWKVRNGFVAKSWREALAIAWPAAIVWILVNALFFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HZ94</accession>
    <name>A0A1B9HZ94_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_05389</name>
        <name evidence="12" type="ORF">I206_107067</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-14 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC73102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009828.1">
        <property type="nucleotide sequence ID" value="XM_019157110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HZ94"/>
    <dbReference type="STRING" id="1296096.A0A1B9HZ94"/>
    <dbReference type="GeneID" id="30173758"/>
    <dbReference type="KEGG" id="kpin:30173758"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972:SF45">
        <property type="entry name" value="PROTEIN CLARET SEGREGATIONAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 6 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="10">
        <location>
            <begin position="182"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="119"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="280"/>
            <end position="287"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCF48609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC73102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="537" mass="59706" checksum="EFDB69B5B8366FF4" modified="2016-11-02" version="1">MSQVDLQALLQSTQNTEREARRDLSSASEELAALRAAHAREIDDLERTVARKDREKRGMEDELRDSRDDLSRERETIRQLKQQLADQSTQHLTLSAQLQASQNQLSIIQAEVECATLKVSSMKAELEVGQENAKKAEELAEIKVRQAEEERDRRIAEIEEDLRNAETIRRKLHNQVQELKGNIRVFARVRPALAHESSSPDALAEIAYGDDRTALETGQSQIVVTSRSESATGQSREQEYPFTFDKIFNPSAGQKEVFEEISMLAQSVLDGYNVCIFAYGQTGSGKSWTMEGGQDEEHAGMIPRAINMIFSVSNGLKDRGWRYQMEGQFLEVYNEVINDLLGNGQFDCKKHEIKTVDGKVSVTDVVSIPLNNPRQVSTLLERARGRRAVAATLMNERSSRSHSVFTLKVKGENPLTNEKCEAMLNLVDLAGSERLEKSGAGENKDRMKETININKSLSALGDVIGALGSGKEGGHVPYRNSTLTRLLQTSLSGSSKTLMLCNLSPLSAHLNETLCSLRFATKVNTTVVGQVKKQIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I000</accession>
    <name>A0A1B9I000_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Splicing factor U2AF 65 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_05582</name>
        <name evidence="11" type="ORF">I206_106872</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC72908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010020.1">
        <property type="nucleotide sequence ID" value="XM_019157302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I000"/>
    <dbReference type="STRING" id="1296096.A0A1B9I000"/>
    <dbReference type="GeneID" id="30173951"/>
    <dbReference type="KEGG" id="kpin:30173951"/>
    <dbReference type="OrthoDB" id="10266058at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12230">
        <property type="entry name" value="RRM1_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12231">
        <property type="entry name" value="RRM2_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12232">
        <property type="entry name" value="RRM3_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000605">
        <property type="entry name" value="Splicing factor U2AF 65 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006529">
        <property type="entry name" value="U2AF_lg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01642">
        <property type="entry name" value="U2AF_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23139">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="262"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="368"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="483"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="595"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="17"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="598"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF48801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC72908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="651" mass="72527" checksum="1DA9B9583B225FD4" modified="2016-11-02" version="1">MDAGYDALEAAASSYVKTRERDDESRSHRSHRDRDHDRDRDRDRERERRHRDRDERDRDRDRGRDGGDDSYRPDRESGRDRHRERERDRDRDRGYEERPRRRRREDDENDLAAQPMSGGGGGGGGGHRDRRPRHEDPYAQPMRGYSPPRRQRRGDEDDWRGGGGGGGGRDRSRDREARRRRGGSFARSPTPPGTVPLEERHVVNSHWDIRPQQFEGVGAMEAKMTGMFTYGPGRVPPPASLGVPAQLMAGSFPPANPQRQTKRIYIGNINDRMSESEIQAFFNKLMHEHKLAVEMPGEPVATCQINNEKNFAFVEFRTADEATAALQFDGVMYEGVPLRVRRPKDYSGVDPLAATFGVPGGSMVDSPNKLFIGGLPTYLNDEQVLELLKAFGELKTFNLVKETGNVSKGFAFCEYMDSNVTDMAIQGLHNFALGDRTLVVQRAAVGRNQNPHHQHAMPGSAAFLQQAVPNILQSNANDVPPTRVMLLLNMVTPEELYSDEDYQEILEDINEECGKYGEVEGVRIPRPVAKNKKWAPGDSAAVSAEKNRQIDEENGVGRVYVMYTKTEDCSKAMKAIGGRQFGGRTILVANVPEEEFLPPAPAPPPPDAGEPPAPTSENGNNSPPPPPPPPAEEDLDAAAADAVKDIMSGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I023</accession>
    <name>A0A1B9I023_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein 242</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_04576</name>
        <name evidence="4" type="ORF">I206_105756</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF48889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC71797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010108.1">
        <property type="nucleotide sequence ID" value="XM_019156306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I023"/>
    <dbReference type="GeneID" id="30172945"/>
    <dbReference type="KEGG" id="kpin:30172945"/>
    <dbReference type="OrthoDB" id="5346979at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF48889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC71797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="27436" checksum="3BE901E611339A87" modified="2016-11-02" version="1">MASFLLGIPNSLPDDLKSPDSKKKKIPIVAVYVAGAAFAITTGLTVLIIPYVRQAAKLQNRIQFLSHRSQAVLDARLRIPRAALPALSSNHPSQSHTSARSSSNPPPSFSSIQSTPISISETNTSNHQAEDPSLLQSRSFNASEEKSLYGGSLTPEDGEAGSHEPVSGLLGFQALTIATALVFGSAGLGAFVVAKLMGVKDMTEFSSKMRESLNLSMPSLISSVNQPGRSVDGFDGQAIDEWVAKLEKEDEENEGRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I047</accession>
    <name>A0A1B9I047_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">quinol--cytochrome-c reductase</fullName>
            <ecNumber evidence="3">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">I206_05632</name>
        <name evidence="21" type="ORF">I206_106823</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="21" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </cofactor>
        <text evidence="17">Binds 1 heme c group covalently per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="3"/>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC72859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010070.1">
        <property type="nucleotide sequence ID" value="XM_019157352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I047"/>
    <dbReference type="STRING" id="1296096.A0A1B9I047"/>
    <dbReference type="GeneID" id="30174001"/>
    <dbReference type="KEGG" id="kpin:30174001"/>
    <dbReference type="OrthoDB" id="5925at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000002">
        <property type="entry name" value="Cytochrome c1, heme protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000003">
        <property type="entry name" value="Cytochrome c1, heme protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002326">
        <property type="entry name" value="Cyt_c1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021157">
        <property type="entry name" value="Cyt_c1_TM_anchor_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266">
        <property type="entry name" value="CYTOCHROME C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266:SF3">
        <property type="entry name" value="CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02167">
        <property type="entry name" value="Cytochrom_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00603">
        <property type="entry name" value="CYTOCHROMEC1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81496">
        <property type="entry name" value="Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 17 18" id="KW-0349">Heme</keyword>
    <keyword evidence="13 17 18" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 17 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="19">
        <location>
            <begin position="98"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR602326-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF48851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="WWC72859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="322" mass="35187" checksum="8E22C4121810ABFE" modified="2016-11-02" version="1">MLSSAFPRIVSRVGAGVKPLSKARFSTSSSNSTPFLASKTAITSSTLLAGGSLIWYNHLYGLNSLLPEASANSAAENGMHPTKQPFEHYGPFETFNHASIRRGYQVYREVCSACHSLDRIAWRNLVGVSHTVDEVKAMAEEVEYTDGPNDEGEMFQRPGKLADYMPAPYPNEEAARAGNGGGLPPDLSLIVKARHGAADYIYSLLTGYCDPPAGVKLADGMNYNPYFPGGGIAMARVLFDGLVEYDDGTPATTSQMAKDVTVFLNWAAEPEHDQRKKMGLQALMILSTLTAISLYVKRFKWSYLKTRKIVYDPPKPARHGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I0H3</accession>
    <name>A0A1B9I0H3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">U4/U6.U5 tri-snRNP-associated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_04733</name>
        <name evidence="6" type="ORF">I206_105910</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNU66/SART1 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="WWC71951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="kpin:30173102"/>
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    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000481">
        <property type="term" value="P:maturation of 5S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005011">
        <property type="entry name" value="SNU66/SART1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14152">
        <property type="entry name" value="SQUAMOUS CELL CARCINOMA ANTIGEN RECOGNISED BY CYTOTOXIC T LYMPHOCYTES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14152:SF5">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03343">
        <property type="entry name" value="SART-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="24"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="273"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
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            <begin position="399"/>
            <end position="447"/>
        </location>
    </feature>
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        <location>
            <begin position="623"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="280"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="430"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="662"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF49046.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC71951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="674" mass="76421" checksum="F471E78DA979F674" modified="2016-11-02" version="1">MSMNQESLTIEEAIKLREQLGLSTAAPVDGEEVPVDKDAEAEANYAQRREDMRKEKEEKDLKERIEKSRNRSALNAKLKGKTLGISNEDDKLDAKSWIKQQKKREKIRAAELAKRAKEMEEADKAIYDERDLSGLKVGHDVDEFQEGEDVILTLKDGRILEGDEDELQNVNLVDDAAIRAAKERKRKAAEQYTGYDDEEFDEDRIGVKADILGKYDDEFSSGKAKSEGFRLGAPVEKKMKIVDDDTEMGSAPATKIKLNLDYTKEFDVSDYAKEGEKGFKKPKKKKAKRSTRKAEDGDEDDMQVDGEPTFTRRVVADGPDNLVDDDDLQAALARSRRENAKKKPKVKVEDLAAQITQQKQEDEAALPVDGADGDEDGRITFDDTSEFVRNVTLESLAAPVKKERVSSPGPSTSRQPEQPVVVKVERAEEGEMDEDEEMSEDEEDEALAEMAAREGLSLDEYRLKIDKQMQEIETIKNEEQGVPTESEPVIGNGVAGILSMLRNQGAIKATTDADKERERIQKEKDLWLADHRRRTAQREYERIMSRGGNKDQAQREFENRMREQQEARDALDNYKTYKPDVNIVYTDEFGRTMTPKEAWKSLSHKFHGKTSGRMKTEKRLKKIAEERKQLTSSATDTPLGMTDAFSRRQQKTGEAHMVLSVGNKQSVPQNNKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I0T4</accession>
    <name>A0A1B9I0T4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RanBP2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_04812</name>
        <name evidence="7" type="ORF">I206_105989</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
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                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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                <person name="Heitman J."/>
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                <person name="Litvintseva A."/>
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                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010391.1">
        <property type="nucleotide sequence ID" value="XM_019156589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I0V0"/>
    <dbReference type="STRING" id="1296096.A0A1B9I0V0"/>
    <dbReference type="GeneID" id="30173229"/>
    <dbReference type="KEGG" id="kpin:30173229"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000164">
        <property type="entry name" value="Chitinase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF392">
        <property type="entry name" value="HAP41P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628245" description="GH18 domain-containing protein" evidence="9">
        <location>
            <begin position="28"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="10">
        <location>
            <begin position="413"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="76"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="229"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="662"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="87"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="229"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCF49172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC72077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="796" mass="82462" checksum="1D85240E8BFD802C" modified="2016-11-02" version="1">MHHPLTRPSSFLFALSFLFSPSSSVSAQHRNLPRNPRQHPHLDERLMPITATTTVVVQRTATHTVWVQPTEQVVVTAPGVGGGSGSDGESTSSSVSSSASVTSESPSIQSASSTSASASIGSESIEATSSSHVHSSAITPSASSAASSIGSGSASSSMYDGSALPSESYISDFPSASFISSLASSTIGASSSHSSHTSIYPSDIPISSLSPSITASASVSALESKITDSEFSSSSHSGSQSASTSLSSSSSIREESSSSSSSISDSSSSVSATSHSHSASRTSSSTSSTETASITDVETASATDSESASQTASETGSLRLNETEIVTATSTQSLTASSTIWPNMTSTLTSDFASSTSSDLTLSESLTSSFDPSSTISVSDTLNISATASVTSTSTSVSASASSSSGLDPIGSTIMAAYYPDWASSHLSPEQVDWSRFDVVDFAFALPTSDNNLEFTQDDSEDLLKRLVTAGHSNGKRVKLSIGGWTGSAYFSTICGNSNSRSTFVSNILAAYNAYNLDGIDIDWEYPGTTGADGNAISSDDSANFLLFLQELRAALPSGAIITTATQVWPFADSNGNPMSDVSEFAKVIDWILIMNYDIWGSSSDPGPNAPLSDACGNSTQPLANAYAAVSSWTGAGMPANQITLGVPAYGYLQQSSATSLKQKKRSAFPQPPHKNSARNEGRASKVTVYNDNGGSSDGQIMFEELISQGALKLVDGEYVGTGGFTRYWDSCSSTPWLKSTYSDQIVTYDDTVSMNLKGQFAAQVGLRGCNVFSIDGDWTGSSWPLTDAVRSGLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I0Z9</accession>
    <name>A0A1B9I0Z9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GTP-binding protein ypt1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_04904</name>
        <name evidence="11" type="ORF">I206_106080</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Preautophagosomal structure membrane</location>
            <topology evidence="8">Lipid-anchor</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010435.1">
        <property type="nucleotide sequence ID" value="XM_019156633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I0Z9"/>
    <dbReference type="STRING" id="1296096.A0A1B9I0Z9"/>
    <dbReference type="GeneID" id="30173273"/>
    <dbReference type="KEGG" id="kpin:30173273"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01869">
        <property type="entry name" value="Rab1_Ypt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000069">
        <property type="entry name" value="Ras GTP-binding protein YPT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057289">
        <property type="entry name" value="Rab1/Ypt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RASTRNSFRMNG"/>
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    </dbReference>
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        <property type="entry name" value="RAN"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00060489"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00074496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF49216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC72120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="205" mass="22457" checksum="52A4D61BAA14C2A2" modified="2016-11-02" version="1">MSAPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELEGKTVKLQIWDTAGQERFRTITSSYYRGAHGIIVVYDVTDSDTYANVKQWLQEIDRYAVEGVNKLLVGNKSDLATKKVVEYAAAKAFADELGIPFLETSAKNATNVEQAFLTMSKQIKDRMGSTSMASGPGAKSTIKGLGQNVEQKTAGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I192</accession>
    <name>A0A1B9I192_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_04899</name>
        <name evidence="3" type="ORF">I206_106076</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC72116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="kpin:30173268"/>
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    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF49211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC72116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="290" mass="32553" checksum="AF45F363857071B7" modified="2016-11-02" version="1">MYYDDSQSPFSRTHTYTIPPASSTRPTTRRFTNPNPVTSDLSLVRCRPNDGANKGESQRFEQALGSRIPTRDSTSADRDWRREPTDPYSDPTILKNAEESLRDVEWAAAANERLGLKPPDASQSPLSDRMEIVNSDESGESRRIAVHWETDTTMTLFLAGKTVNLPNGELTKVRPTTLIYDMNHEGISSLDLDTWSAHLNIFQAIHAIHPHIPDKYKQSMASSLLDSAKGWYHQEVSESTGYSADPNFSIRRFHTAPRGGYRVAYSKPAPFPESGCYCQSICCFCGQSFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I1C2</accession>
    <name>A0A1B9I1C2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Protein PBN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_05031</name>
        <name evidence="13" type="ORF">I206_106207</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase GPI14.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type III membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the PIGX family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1296096.A0A1B9I1C2"/>
    <dbReference type="GeneID" id="30173400"/>
    <dbReference type="KEGG" id="kpin:30173400"/>
    <dbReference type="OrthoDB" id="5546453at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990529">
        <property type="term" value="C:glycosylphosphatidylinositol-mannosyltransferase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042322">
        <property type="entry name" value="Pbn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013233">
        <property type="entry name" value="PIG-X/PBN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28533">
        <property type="entry name" value="PROTEIN PBN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28533:SF1">
        <property type="entry name" value="PROTEIN PBN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08320">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 11" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCF49340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC72245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="213" mass="24084" checksum="E43DA7BBD87DC3AE" modified="2016-11-02" version="1">MSLSSLNVDLSISTPSLHPTITLHLKTPSTSILPDPCNLQAKLSIRLPDEIFLDPDELSDKFAGSAVTSYSLFNSKTQGKVKVDIERPAISNITEHTILNLNIKVSEKKFENLRIEIPLHVRYLNPTEDGKTIIKFPSTEGKIKGRWYCTEISDSLPFIDPTPVNIIIPTGQHSHQPFVELITPLVIWAGWGWLIYKIIRLRNRSKSLKEKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I1N2</accession>
    <name>A0A1B9I1N2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Trehalose synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_05061</name>
        <name evidence="10" type="ORF">I206_106235</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019156785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I1N2"/>
    <dbReference type="STRING" id="1296096.A0A1B9I1N2"/>
    <dbReference type="GeneID" id="30173430"/>
    <dbReference type="KEGG" id="kpin:30173430"/>
    <dbReference type="OrthoDB" id="937291at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052078">
        <property type="entry name" value="Trehalose_Metab_GTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049438">
        <property type="entry name" value="TreT_GT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47779">
        <property type="entry name" value="SYNTHASE (CCG-9), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12100)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47779:SF1">
        <property type="entry name" value="SYNTHASE (CCG-9), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12100)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21269">
        <property type="entry name" value="TreT_GT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Trehalose synthase N-terminal" evidence="8">
        <location>
            <begin position="235"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="7">
        <location>
            <begin position="448"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21269"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF49368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC72273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I1P1</accession>
    <name>A0A1B9I1P1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_05071</name>
        <name evidence="3" type="ORF">I206_106245</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010597.1">
        <property type="nucleotide sequence ID" value="XM_019156795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I1P1"/>
    <dbReference type="STRING" id="1296096.A0A1B9I1P1"/>
    <dbReference type="GeneID" id="30173440"/>
    <dbReference type="KEGG" id="kpin:30173440"/>
    <dbReference type="OrthoDB" id="3358750at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39475">
        <property type="entry name" value="CONIDIATION-SPECIFIC PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39475:SF1">
        <property type="entry name" value="CONIDIATION-SPECIFIC PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF49378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC72283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="135" mass="14686" checksum="DE838E68FCE02AF3" modified="2016-11-02" version="1">MSDAQAIEQQNPGLDTKHDSAGAKHPATGGSGNPQTGEPYEIAKPDAHKRLDGKDERSHPNAIEDAKRVESLEKEAEKAHEDALRHPTAAALSHGNKPSSGAVKDEKILDDEEEELRKKDEAKKQSAEAHKPKHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I295</accession>
    <name>A0A1B9I295_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exocyst complex component SEC15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_04198</name>
        <name evidence="9" type="ORF">I206_104224</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the SEC15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010895.1">
        <property type="nucleotide sequence ID" value="XM_019155937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I295"/>
    <dbReference type="STRING" id="1296096.A0A1B9I295"/>
    <dbReference type="GeneID" id="30172567"/>
    <dbReference type="KEGG" id="kpin:30172567"/>
    <dbReference type="OrthoDB" id="10267033at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.30:FF:000004">
        <property type="entry name" value="Exocyst complex component SEC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.670">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.30">
        <property type="entry name" value="Exocyst complex subunit Sec15 C-terminal domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007225">
        <property type="entry name" value="EXOC6/Sec15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046361">
        <property type="entry name" value="EXOC6/Sec15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042045">
        <property type="entry name" value="EXOC6/Sec15_C_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048359">
        <property type="entry name" value="EXOC6_Sec15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042044">
        <property type="entry name" value="EXOC6PINT-1/Sec15/Tip20_C_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702">
        <property type="entry name" value="SEC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20651">
        <property type="entry name" value="EXOC6_Sec15_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04091">
        <property type="entry name" value="Sec15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025007">
        <property type="entry name" value="Sec15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC6/Sec15 N-terminal" evidence="7">
        <location>
            <begin position="56"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex subunit EXOC6/Sec15 C-terminal" evidence="6">
        <location>
            <begin position="406"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR025007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF49676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC70274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="786" mass="89288" checksum="EC810546D13A4375" modified="2016-11-02" version="1">MIRKQRPTFTSSELEMQLQQINLDPTSSTTENLEALAPLIKSIQDSDSEQLYLRSLDKFVEEKEREIEKICQENYEDFVSSVSTLLTIRQGSGHLRRRIGELDGQMGDVGRALGEKKRALLEQKKVARNMDDAIETLQTCLRLLDLVHRVGEMIREGKYWGALRSIEDLLHLTPPSISQTPFYAHILSSLPSLRLSIKDAVTASTKSWLFDVRESGSKVGKLALEQMSQRIKKWRTKREKEGGVRLARVGGAMELVHNERVEFDALDNDEIKVDFKPLYQCIHIYEALESKPELQRNYQVDRKTQATLILTSRLSTTPETLLSTLPLLMQELVGFFIIESHLLRTMPDFRTQRDVDELWDEMCKRIVEVVGTGLKGCSEPEVFLESKTNVLLFVQTLEGYGYNITELNGLLITLFERYSELLLRKFSTDFDHIVSEDDNQPMMVNDQEEFDQVAGVCWLAPGEMESLAMQGFPQAMPFSQTYPMCCINIRNFVDQFYQFTDGVAQQHLDIDEVLRKSLDGLLSDHVSKQIAKRLQNMSNLSQIAQVVINLEHFSTACDELEGVLMNLRASQRGGPVHLSSTQSFVQTLETAQNRIDSVINSKLESFFELAEYNWLPARPQSTASEPSTYVFEMITFLTAYVDSVLIGLNEGVKNRAYVHALGRINKWLMDTLCGREVVRFNEMALASVLADVTFIETEIKRLDKAGLDRVFEEVKHTINIVLTESVSAYMEPSIRSMSYPSVKPIRLAVILAKLGKAHALGGVQSSMVKAERRRREADEVAKLAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I298</accession>
    <name>A0A1B9I298_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_04169</name>
        <name evidence="3" type="ORF">I206_104255</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010866.1">
        <property type="nucleotide sequence ID" value="XM_019155908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I298"/>
    <dbReference type="GeneID" id="30172538"/>
    <dbReference type="KEGG" id="kpin:30172538"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF49647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC70305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="244" mass="26664" checksum="3B096AEB402FB2DB" modified="2016-11-02" version="1">MFVQGEFTTLDEGATERTTKYYVPLDNSKSTIESIKGDRRKLLIATTAGTVFKDVYDHVYGRLPPGLIRANTNENYIPKPLGTNDARIKITVVSTENGPNKYIVTNMEQNATLQSAEPLLPDEFLYENSEFPSNSATAFKAWWDRYGKATHILSPTGSNAINSDCMTGVTKSSNGTQGSVPKPVFQDPSVKLAEKDEDTESVVTTDAASKPAATQVTDWDTDSDTDMFEPGSSTPPDDDGFEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I2F7</accession>
    <name>A0A1B9I2F7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">RING-type E3 ubiquitin transferase (cysteine targeting)</fullName>
            <ecNumber evidence="17">2.3.2.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Peroxin-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">I206_04247</name>
        <name evidence="22" type="ORF">I206_104178</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="22" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-S-ubiquitinyl-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.36" evidence="17"/>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010942.1">
        <property type="nucleotide sequence ID" value="XM_019155984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I2F7"/>
    <dbReference type="STRING" id="1296096.A0A1B9I2F7"/>
    <dbReference type="GeneID" id="30172616"/>
    <dbReference type="KEGG" id="kpin:30172616"/>
    <dbReference type="OrthoDB" id="1701437at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025654">
        <property type="entry name" value="PEX2/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48178">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48178:SF1">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pex N-terminal" evidence="20">
        <location>
            <begin position="41"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="369"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OCF49723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="WWC70228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="429" mass="48763" checksum="2193C541427BA773" modified="2016-11-02" version="1">MASPQRIIYPGESPSESSSSISMIIPLNAPKVNQIDSDDLDSALVEMMSDNLTKSLDNFKLTFSNGFRPEIELLIQLIIFKFGIWSSINASPGLKMQNMKLISSKTINPTKKILILYLLLHPPIFPRYFLNRIREYALSKQWSDLPNYDLRKKAWRLIGRLENLSRIWELIGWLGFLYDGKYPSLLMRILQLKLVPAKPHLARMVGYEFMNRQLVWGTFTEFLMFAIPLLPPFPPYLSPSAHLNRMRSLLSPPQKIDYSTIKSQPMANGIHSQRHKGIYADLPLSTCPICHSRNITAPVPLSSSAQGSGLNLPPIEGAGGFGHELDSDENKIFVPAQTDCKGGCRWCYYCIGEELFKHNERVKAYKTSTKKLESKKDAASVQQKDLREKNKIIQEDNQNEEEEKWECLRCGDGVSRAWRVGTEDGNALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I3A9</accession>
    <name>A0A1B9I3A9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_04535</name>
        <name evidence="7" type="ORF">I206_103892</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Goldberg J."/>
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                <person name="Imamovic A."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
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                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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    </evidence>
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            <dbReference type="EMBL" id="WWC71769.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
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    </evidence>
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    <name>A0A1B9I3K5_9TREE</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
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                <person name="Dewar J."/>
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                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="14">CBS 10737</strain>
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    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Roberts A."/>
                <person name="Saif S."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
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            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
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            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
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    </comment>
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    <dbReference type="Proteomes" id="UP000094020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048761">
        <property type="entry name" value="SMUBP-2_HCS1_1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN SMUBP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21138">
        <property type="entry name" value="SMUBP-2_HCS1_1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="232"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="250"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCF50031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WWC69923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="758" mass="83776" checksum="84F5A5E7854C1011" modified="2016-11-02" version="1">MVSGILHPATPSRSVLEAFINRHQYLLELERKAEEEQTRLLNSKCSPKLLEQRGLALGGLGCSNISVGLGGKSLIELNRPSAYHTSPLLPPHTFRSGDPVRIETHISSSATNKTKGKKKDGEDENAVEGIIYKISQEKVVVAVDEKKEIDLPERLRLLKLANTVTFDRMDKTLLHLKRIILPEEGSSTPNIPNFPLINSLLGIQLPSWSDEITPPIKQHEENIQKESDVTWFDENLNDSQKAAIKFCLKANDVACIHGPPGTGKTHTLIELIFQFLSRPANPNTTQPPRILITTPSNLALDNLLLRLHALSQLPTYSDLLPPGSILRLGHPTRVHKDLIGETLDYRAANGDEGELLKDVGSELQGHLSDLGKKRGEKGAVKGKERGKKWEEIRELRKEYRQREGKVVTSVVSRAQVVLATCHSAGSRQLNNIIFDVAIVDEATQAIEAVCWVPILKAKKLILAGDPQQLPPTIMSKEDKSLKPVEGLAEELNGIDVKSHTTLKPPKTLETTLFERLESLYGEGIKRVLQIQYRMNEIIASFPSDTLYSSALISHSSVARRTLLDLPVIKDSEVGTTEEGKDVLEPVAVFFDTAGCEFYERTEGNDEMGVTKKEKGSLGEGSKSNENEAVVVSKWARKLIGLGINPVDIGIVTPYQAQVSLISSMLHEEFPEMTIGSVDGLQGQEREAIILSLVRSNPTGEVGFLGEYRRLNVAMTRAKRQLCVVGDSSTVGKGSKYLKKWMEWLENEADVRYAGDEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I3T9</accession>
    <name>A0A1B9I3T9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ataxin-10 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Copper transport protein 86</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_03507</name>
        <name evidence="9" type="ORF">I206_105592</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play a role in the regulation of cytokinesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ataxin-10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011407.1">
        <property type="nucleotide sequence ID" value="XM_019155253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I3T9"/>
    <dbReference type="GeneID" id="30171876"/>
    <dbReference type="KEGG" id="kpin:30171876"/>
    <dbReference type="OrthoDB" id="379794at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051374">
        <property type="entry name" value="Ataxin-10/CTR86_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019156">
        <property type="entry name" value="Ataxin-10_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255:SF0">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09759">
        <property type="entry name" value="Atx10homo_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ataxin-10" evidence="7">
        <location>
            <begin position="426"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF50188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC71634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="518" mass="57480" checksum="1D0EAED0ECC51CDF" modified="2016-11-02" version="1">MDTSGLAAALIQGSEVILKSDEACLDFARSSEGVARYIAQNLDERQELVDLDDEGNNIFDALNLLWAKLAKSFDPSQATANHSEGWASEDSRIQLALGLGKLERNLIAGLQTFQDIAEQHEESLRALIFHVTTFIRIADERFFTLQSVLAQLLCNLISPSSAQPGADRLADKYLQLYLSGGRNEDIIIRLLDSRDTKTNNATLHLLNNVVRGNEARLRLLLSGVGVRWLAKILNRMDEWVEVQNGLFELGASIFNNIIDHSLHPELFQLLSDPAEVITPSQTILLKVLDSHLSSSTQSSPSPSPHLFMIGLFHNLAKYSKISIDSKQDDPRLPKIFEGLILVTEGLSAIGLSVQSRKDENYSLQEDLNGDEEVVRTMKDGTNGVVKPSIDLLRSLDTFFPRINPRAKSTGASITSISDELKPFSNLKRNLVQLLGILTFEDTLVGDQVREEEGIQLILGMTEIDENNPYLREHALLCVRNLMLNNPSNQSIISQMNPVGVLSPDNGELLPVPEKMKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I3W3</accession>
    <name>A0A1B9I3W3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ZZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_03529</name>
        <name evidence="8" type="ORF">I206_105568</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="473"/>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I4D5</accession>
    <name>A0A1B9I4D5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Copper-fist domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_03701</name>
        <name evidence="11" type="ORF">I206_105392</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="WWC71436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019155445.1"/>
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    <dbReference type="GeneID" id="30172070"/>
    <dbReference type="KEGG" id="kpin:30172070"/>
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        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.430.10:FF:000001">
        <property type="entry name" value="Copper fist DNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.430.10">
        <property type="entry name" value="Copper fist DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051763">
        <property type="entry name" value="Copper_Homeo_Regul"/>
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    <dbReference type="InterPro" id="IPR001083">
        <property type="entry name" value="Cu_fist_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036395">
        <property type="entry name" value="Cu_fist_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00649">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00617">
        <property type="entry name" value="COPPERFIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM01090">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00412">
        <property type="entry name" value="Cu_FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57879">
        <property type="entry name" value="Zinc domain conserved in yeast copper-regulated transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01119">
        <property type="entry name" value="COPPER_FIST_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50073">
        <property type="entry name" value="COPPER_FIST_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Copper-fist" evidence="9">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="170"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="504"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="843"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="924"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="967"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1113"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="256"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="504"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="538"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="580"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="609"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="675"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="722"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="737"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="924"/>
            <end position="939"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF50380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC71436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1228" mass="130981" checksum="C1BEC769EFC25369" modified="2016-11-02" version="1">MVLINEKKYACEKCIKGHRVSGCTHTDRPLYEIKKKGRPTTQCSHCKDKRKTAGSSVHTKCSCGDVKTPSTTSAVIQPIANQSNLSEQTPTLQDVDQDEEIEFETRKGQPGSKATFPRGFKDVLELAAAANALAGLVKEDTPYKVAERSVNALLNPCKCQSGGPCKCCHPKKAERSDQSGDTSPSSGGGCCSTSAAGAGDVVSRPGPPPNAIPYLSPENMHHPAHTSPHVHKTKLFSPYSTNTASQSRHGRRDTISSRSSGRSSPLPSKILRPPPPTIKPLTDFGRLIGAAINQDGSINSEIPRSAVGLPNLPGISTFDTAAENGGAKVEPMEYEDIDIDMPLSFPTSEDVVIGACMCGEDCSCPNCATHDNGITSTNSENGHRHKGGCGESCKGRNDCNHSISVPSGVTSIAHLISLAAAHVPPPPEAQAPRYASALDPHDTRVLPPSAQLSADVARTMGIVQLKPLECCNGRCQCPPGQCVCEKECCGCCVRCACSEEDEDARMSNDDDHTTSQAAVSVASSRPKSSCCGGKQNVDGPNTQPSPVTASPTGATIASSSYQPSPTLLSPGHAQLPLNYGSRQQSPVTSGSTTPVNLPPVSTTTPTNGAAVRRAISISSRSAQEGHDVSSASHRRATVTGNLPAVTGPNSAPIKASSKTINPYNAHHHRTILPKPSNSHLSTNTSATIAGNSRQPSPSGQKRGSTSAGPARNESPSGERRTSGSSVSTRDQMGTSRQYQPSPTVPSQPSQSELPTTNQVDNAHGLPDSGLGYQWPPQYCQEILQSQYPAFGVVSETMNQQTDIASFTNPNQNNYPSSMHILGNGSDIDPSNATLLAFLQQFSQPNSQSSQAGLQHEPAPMPLNQAPPSNPTHSQASLPGPPHFDQSWFSQVQQPALSHDVSGTTSPELDLPFDLDQFLAQTLNSNQAQPHSESNNNQPQHHPGVAADLNPNFNDFFFNNAVTPNVAVQSHSQPNSSGQTNGVQNANNDLVQTDPPFIPLVPGLPIEHTYSPNWTSNGMKEKIVEDQRRQLRETNEITNSHQHQPSRQDILINNQTRRQIETSTGDIIDLSKPLDSDTLNKIMMALQKHNETFIPDSNSSTNAQPNINNELSSQNITNLPDQGVIPNNPNPNGNTKDLDDMFNQFVTLDGVVNSNPNSNSNSNITSNADGMNLNNINEDSNTNTNTNTNTNIIEDPNSWLKIQCNVDGLNWANNEMWGNNSSSSGSNYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I4L9</accession>
    <name>A0A1B9I4L9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Gly-Xaa carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_03774</name>
        <name evidence="11" type="ORF">I206_105316</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011671.1">
        <property type="nucleotide sequence ID" value="XM_019155517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I4L9"/>
    <dbReference type="STRING" id="1296096.A0A1B9I4L9"/>
    <dbReference type="GeneID" id="30172143"/>
    <dbReference type="KEGG" id="kpin:30172143"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05674">
        <property type="entry name" value="M20_yscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000085">
        <property type="entry name" value="Gly-Xaa carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017141">
        <property type="entry name" value="Pept_M20_carboxypep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047177">
        <property type="entry name" value="Pept_M20A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE/HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962:SF1">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE_HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037217">
        <property type="entry name" value="Carboxypeptidase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="9">
        <location>
            <begin position="290"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="587"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF50452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC71361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="618" mass="68072" checksum="0BB1E38078FF9752" modified="2016-11-02" version="1">MVMSDEKALLPSSSIQGGNSPSKPGWFNRNRKSLTLVLGLFLILQHFIISPYLLDLWEDASYDSNVTRKSTCEQAEAIYPKSFDVSSVVEGQKDRLVNWLSGAVKIPTEIFDVMGEIGEDDRWDVFYKFADYLETSYPLVHQHLKRTRVVTHALIFEWEGSDPSLKPLLLTGHQDVVPVLPATRGLWTHDPFGGEYDGEVIWGRGATDDKSGVIGALSAIELLIESGKFTPARTVILAFGIDEETGGKVGAYHLGQWIEEKYGKDSISILVDEGNGLAEAWGQLFAAPAVGEKGYMDLELKVETLGGHSSVPPPHTGIGYISLLIAAIEKHPHKPHLNIESPLVNFLACGADSAPKFPGHLKKSIRKVEDSLLSKHGKVDRKALKEVEDWWVEGSYLDGTLPKGMGNAMVGTTQAVDIINGGLKVNALPESVVAIVNHRISLASSVAELQQQLIDVISPVAHKLNLEVEAFGNDIQYHDCHMHQDLSGPKVGKVILNVAFNSSLDPAPVSPFTVDSPAWRLLSGTVKGVYATRPEAKLSAEEAEKTIIMAPSISTGNTDTKRYWNLTRNIYRFAYQEGKGNRFNNVHTVDEFLPADMLVEEVRWFANFIVNVDESREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I4R7</accession>
    <name>A0A1B9I4R7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_03828</name>
        <name evidence="3" type="ORF">I206_105263</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011723.1">
        <property type="nucleotide sequence ID" value="XM_019155569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I4R7"/>
    <dbReference type="STRING" id="1296096.A0A1B9I4R7"/>
    <dbReference type="GeneID" id="30172197"/>
    <dbReference type="KEGG" id="kpin:30172197"/>
    <dbReference type="OrthoDB" id="10000533at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05262">
        <property type="entry name" value="SDR_a7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF9">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF50504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC71309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="299" mass="32629" checksum="5970B1D1A047C323" modified="2016-11-02" version="1">MKVFITGASGWVGRHVVPELQSHGHEITALARSDSSADALEKQGVKVIRGGLEDTDILHSAAKESDAVIHLAYIHDFSDYGGKPAQIDFEAIKAMASALEGTNKIFVGTSGALGLQGEQTEKDSSAGGPRKIGEEITFSFKEKGVKTIVIRLAPSIHGKGDKGFIPILINFSKKSGYSAFIENKPINWKGCHVKDASILYRLSIENEKIPNGSILHGISDEIGIPFSEIAKSIGNNLSLEIKAFNSIKDEDEIKKHFDWMAMILNYDCNAKNQITKEITGWIPKEKGLLEDINTGSYFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I4T1</accession>
    <name>A0A1B9I4T1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Solute carrier family 45, member 1/2/4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_03846</name>
        <name evidence="9" type="ORF">I206_105245</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011741.1">
        <property type="nucleotide sequence ID" value="XM_019155587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I4T1"/>
    <dbReference type="GeneID" id="30172215"/>
    <dbReference type="KEGG" id="kpin:30172215"/>
    <dbReference type="OrthoDB" id="28755at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008506">
        <property type="term" value="F:sucrose:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432:SF91">
        <property type="entry name" value="GENERAL ALPHA-GLUCOSIDE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="640"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="720"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="494"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="494"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="538"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="581"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF50522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC71291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="752" mass="81866" checksum="53D1E7136F316E9E" modified="2016-11-02" version="1">MTGGAFFASSGGDEEFDLDEQGNERHPVQWIGTANVKGPRWARLPLLTVGMLGIQCVWSIEMGYASPYLLELGLSKSFMSLVFMAGPLSGLIVQPLIGIFADRSKSPLGRRRPFMLAGCVICVFAMMMLGWTRELASIVNGGKWLSIALAVWSIYLIDFSINAVMSTDRALVVDTLPPREQEEGSAWAGRMFGFGSVFGFFVGNLDLPPVLPFLGKTQLQILSFMTSAILMITHTFTSWAVSERVLLRDDRPQSQSSLKANLKSIWDNIFSLPPGIRTICFIQFFASLGWFPILFFTTVWVSEIYKNSVPFTEGMDETTFSNDAVRSGARALLLQALVNIVTSIGFPFLVSESGVQPEASHQYSSLNGQGGLPENPPNSAIWKRAKEEIQAGGVVKKAIGLLGGLVEWVKDGSAWQIPYKGLTLIKVWWISQFVFAGAMAASWFVTTVSGAYFVIATTGFCWALSQWAPYSLLGELILIDGTIDRSQPLSIIRTRPSTDVHQSMNADSGYPYDPHPSTSNSPPLHHNEGSFVINDEDHETKEKVDEDEKLDKPVGGGLSPLIVQGEQAEPEPGLGSTVILRHSDEYSRSDISEEDDLPRGSTQSNHRTISPRPASPHLPSTDKGPSTADKAGVILGIHNVFLVLPQFVVTFLSSIIFYLMEPEKGLPAHNPHTIIPISGNVTDTSGEGIESVVSEIGDEVIKRLISRAEGLTSEGSSPDAVGLIFRIGGVSAAIGGYLCWRSSRDWAKGKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I4T7</accession>
    <name>A0A1B9I4T7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ATP-binding cassette transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I206_03869</name>
        <name evidence="15" type="ORF">I206_105222</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011763.1">
        <property type="nucleotide sequence ID" value="XM_019155609.1"/>
    </dbReference>
    <dbReference type="STRING" id="1296096.A0A1B9I4T7"/>
    <dbReference type="GeneID" id="30172238"/>
    <dbReference type="KEGG" id="kpin:30172238"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000825">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF353">
        <property type="entry name" value="ABC TRANSPORTER ATP-BINDING PROTEIN_PERMEASE VMR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="389"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="509"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1027"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1097"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1169"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1193"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1281"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1305"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="353"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="694"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="1030"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1372"/>
            <end position="1676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="920"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="935"/>
            <end position="950"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCF50544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WWC71269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1700" mass="187464" checksum="D5F9C7E367385147" modified="2016-11-02" version="1">MFTIYNLESLSSKLVDITNQATCEDIWDGTDFTPCFVERYINNIPFLIIGLSALYIIITTSIPRYIPSNTYTPLTTETLISPSASSDLAKLESNVILDAVASNLQTSSKPSETGKLSDGEAEQLVKDWKRNSKRAELKWRRLRFWVGIIGALAWFELEIARGVIEGSWRDAVFPGWLALIALIPSSPLTAILTIHVLPSLIAFRSNIVQPHTSALIIASGILEVVYWIAMISIPYSENLDRLLEKGFSQGGGTSGSYGTKLPKHCEEPASVFSRATYTFILPLLFKHYFQPITLQDIPAIREDDSASSSLGAFRAYRASRDKKYLAKTGETRVRNLGADLFWFFSPELAYQCIWAVLFVLFQYLPPTGLRLLLQFVKERDTSSQPGHVAVLYVAMMAGGQVLGVVLMGQSLFIGRRLCIRLRAIIVSDVFAKALRRRDLSGNVKKTKVDKSGKVVDDPEAAASEGKIANLVSVDAFSVSEICAYTYYLVSCPFAVILNSVLLYNTLGPASFAGTATLIVLMPLQGLIGRLYTIYQKRFMGATDARLESVTEVIAHIKLIKFNAWEDKFFERMGIARKKELGVLAYRFATSTLFQIFVWGTPVLVTGVAFAVHSMVLKQPLTADRAFASLILFNMLKDPLALFQDTLTRLLQAYTSCGRIQAYLDEPDTLKYRQISTPKAGEPTIGFKNAIIGYTTHEDLNQLVDGDAKPFALGELDLSFPLGGLSIIAGPVGSGKTTLILGLLGEAMLLQGKIFMPDDHANREICPIDPATGLADTVAYCAQTPWLIGASIKENIVFGSEWDSKRYNDVVDACALRRDFEIFELGDETEVGEKGTTCSGGQKARIALARAIYSSAKTIILDDVLSAVDAQTARHLYDNTLQGRLVEGRTMIMVTHQVNLVAPASKYIVLLEDGQVLSAGTPRELSSNGHLDLHDSSASSTPTAASSSADLSPKHPEGGETEDLIEPVLDTEPAELLEIQKQIEVDKAAETTSEVKLDKQLVAAESSGQGMVGLGTYWLYFKSMGSGLFWFLVIFAFIGSQILQIANNTWIKEWANSNDRASSSIPTISSFLTSRENIQQEIQIQLTKQRSTVFYLTVYWGISGCYVLAVAARVGITFFGALTASQELYGKLVRRILGAKMRFFDSTPSGRIMNRLSKDMSSIDTEAGEILMYFANSCLAAGAILLVVTVSTPAFLLALVLIVLAYWALGSLYVTTNREIKRIDSVTRSPIFISFSEVLVGMSTIRSYGDSARFMRKLFQEVDQNTRCFWYLWQINRLLNNFSNFIGAFVTIFAAVFALRNPDMDAGAVGLSITYALSFTEYVLWVVRLYAASEMSMNSVERVGEYLELEVEEEEHAKGIEPPAYWPSREGSVVVENLTCKYAPQLDPVLQGVSFTIGPREKIGVCGRTGSGKSTLALSFFRFLHQEGGKITIDGIDIAKISLKALRSRLTILPQEAQLFSGTVRDNLDPFDQHDDSAIWEALSQCGLVNKSRYPSRVTSKADLTSLTQTKKLSTPSKNTLRGQASVRNLMKKVDNKLETLQVGQNGDAIADGDQVEEEERVMIRSLDEKVAVGGKNFSQGQRQLLALARGLLKLRSSSFLIMDESTANLDHATDATIQNVLRSEMKDVQMIVIAHRLMTVCGLDKILVLDHGKVVEFGTPYELMQKENGSFRELCKQSGEESQLLELAKQVHESIGGQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I4Z6</accession>
    <name>A0A1B9I4Z6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_03929</name>
        <name evidence="6" type="ORF">I206_105161</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011823.1">
        <property type="nucleotide sequence ID" value="XM_019155669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I4Z6"/>
    <dbReference type="STRING" id="1296096.A0A1B9I4Z6"/>
    <dbReference type="GeneID" id="30172298"/>
    <dbReference type="KEGG" id="kpin:30172298"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008448412" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="27"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF50604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC71208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="551" mass="60809" checksum="3709959C1B739C95" modified="2016-11-02" version="1">MTTLKTVLPLLALVSVTTSSVLPRWAAPIVKLPYATYQGFHNESSGLDIFLGVRYAASTEGQNRWREAQPPLEQSGDGILNATVFPPQCPQATAGGIISAADYNPLQSEDSEDCLFVNIYAPPNADNLPVLVWIHGGGWDHNSAREFDPTPSINYSNNSFIGVIIQYRLGAFGFLNSPLMKQDKGLNAGITDAAASLRWVQNYINHFGGNKDQVTIWGQSSGGGTILHLLSAQGEKNRENEKLWNNVIMSSPYLTPMGSCNSTYWQTQFDNFTASANCSVDASALDCLRNTSTDVLKTLSHKFDSILGKGHPSAYEPCIEGEGGYLVGNTAERLKNGNIPNSYILAGSNYNDGFSMVSTSLTPPSNITNVSAEADARLANLLITDFPLIQGSEDVQRAIELYPLSDFVDNHARAAELYQDIIFACGVDWTLDKTQDSWRYLYAVKDAIHARDNAYEFPYFYNTLSPYSPTLYGSYIGPIISLIISNSPNNYSNLRPPNDPSYPIYLDMGEYKVLNVTVANISDSYIGQNQQQIGTRERCDFWAQVRIDNYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I503</accession>
    <name>A0A1B9I503_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RING-14 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_03886</name>
        <name evidence="9" type="ORF">I206_105205</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011780.1">
        <property type="nucleotide sequence ID" value="XM_019155626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I503"/>
    <dbReference type="STRING" id="1296096.A0A1B9I503"/>
    <dbReference type="GeneID" id="30172255"/>
    <dbReference type="KEGG" id="kpin:30172255"/>
    <dbReference type="OrthoDB" id="5588846at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327">
        <property type="entry name" value="RING FINGER PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I609</accession>
    <name>A0A1B9I609_9TREE</name>
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        <submittedName>
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    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1">CBS 10737</strain>
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    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
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                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <source>
            <dbReference type="EMBL" id="OCF50956.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC68731.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I682</accession>
    <name>A0A1B9I682_9TREE</name>
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    <gene>
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        <name evidence="11" type="ORF">I206_102755</name>
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    <organism evidence="10">
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        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
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    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="267" mass="28986" checksum="E6DC208EA635681E" modified="2016-11-02" version="1">MRVFSHLLALLTLVIPSILAVTLSGQIQFGNLITRETLPVGSKVSINHGERKVWIKGDGSFEISNVDEGEYILEPIIPGYIFNSYFITIESIIPIESNSPINSNSNSNSKSDSEISISSIEPTFIIHIQPFYPSKLPLPINSISLNHPLIITPLSKEDYFINKGGMNILGMLKSPMVLMMLFSAIMLFALPKLTAALADDPEMAKEMADTRARMNNFQSMDLAGSLSNMLAGSSENAPVTNTIQASSGSNTPNRSGANAGGKKRRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I6A4</accession>
    <name>A0A1B9I6A4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycogen storage control protein</fullName>
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    <gene>
        <name evidence="2" type="ORF">I206_03121</name>
        <name evidence="3" type="ORF">I206_102766</name>
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    <organism evidence="2">
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        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="OCF51056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC68831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Cyclin_PHO80-like"/>
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    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF94">
        <property type="entry name" value="PHO85 CYCLIN-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    </evidence>
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    </evidence>
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            <dbReference type="EMBL" id="WWC68831.1"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="54200" checksum="F2251258A17C44A6" modified="2016-11-02" version="1">MNGSSLVTENEAGPSRSHSHHQIRRSSHSNTHTRSQSQSSSTSQRRQSYSSYSSRVQPESTIEDEEGNSNSNSRKGKSHHLDIATYPTQQLLRLLAGLLQHIATSNDALRVDLDPDLDESNTAIGDGQTETLKEESSPLNRNASSRSRSHSRTSSSLSQNHISSSSSPTTALFDQSEQSSSSSSSNVAENLTSHEAGSSISNDEFPLFTASKSSLSHPSSLLAFHARHIPSISIEAYLLRILKYCPTTNEVFLGLLVYFDRMTRLGTPQGVGGTQAIFGGGGKDGKGKSFAIDSYNVHRLVIAGVTVASKFFSDVFYTNSRYAKVGGLPPTELNSLELQFLLLNDFRLRISLEEMQKYGDRLLAYAEEQEEKSKLETERERERMEKSQIEDGDGMNANGSSEQSQSVASASTDTTRPSDEPHPTTPQTNIKTSSMKPSTSNPPPSQENGSDVKIGTAGSNGVTPSQSAINSTTSGPSGIRDWVRNEEVLTSRMASPIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1B9I6Z2_9TREE</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_02029</name>
        <name evidence="3" type="ORF">I206_104498</name>
    </gene>
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        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012534.1">
        <property type="nucleotide sequence ID" value="XM_019153794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I6Z2"/>
    <dbReference type="STRING" id="1296096.A0A1B9I6Z2"/>
    <dbReference type="GeneID" id="30170398"/>
    <dbReference type="KEGG" id="kpin:30170398"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF58">
        <property type="entry name" value="PROTEIN HMF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF51315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC70547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="129" mass="14008" checksum="3C435B3FCD74C07C" modified="2016-11-02" version="1">MPAQITHVTDVPDMKAVPHLLSPAVRLGDTLYLSGQTPIDGTGKVVDGDIEELTTQCIRNLEKVLKHAGGSLNDIAKVNIFLKNMDDFPRVNAVYEKLMPVPKPARSCVQVAKNPGDVRIEIEAIARAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I786</accession>
    <name>A0A1B9I786_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Pheromone-regulated membrane protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_02070</name>
        <name evidence="11" type="ORF">I206_104538</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ThrE exporter (TC 2.A.79) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012575.1">
        <property type="nucleotide sequence ID" value="XM_019153835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I786"/>
    <dbReference type="GeneID" id="30170439"/>
    <dbReference type="KEGG" id="kpin:30170439"/>
    <dbReference type="OrthoDB" id="413008at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051361">
        <property type="entry name" value="ThrE/Ser_Exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024528">
        <property type="entry name" value="ThrE_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082:SF4">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12821">
        <property type="entry name" value="ThrE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="684"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="709"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="742"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="850"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="879"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="904"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="933"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="972"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/serine exporter-like N-terminal" evidence="8">
        <location>
            <begin position="520"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/Serine exporter ThrE" evidence="9">
        <location>
            <begin position="855"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="59"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="157"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="304"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="352"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="411"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="456"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="352"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="375"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="420"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="470"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF51356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC70587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1004" mass="111400" checksum="CA62F027C54ADB4E" modified="2016-11-02" version="1">MSQPPRPALKPGDRKDSKVRFSREELAPIRSDPSDFLPSTDPRASIGSTYIDAQEGEYYDNEGSYPFNSEPVELSESVDNPSQHQEYYREYPVEEEPQYIQNHEPLNDTYTAPPRVVGGRRWSNAIHRPTLDTLHSTEEEYHQQQITSSPRNSVIQAQQYREDQPSPYRPPSALRSSLAHRGDSPRSGESPFREARSSAPNIGYTPPRRMLEQHRFSVPNGSPNIVPNGASNRQGGNQDLYSPGNRGTFGERERRYSPVPAYQEEVYAQNDQRRGSIINHQERENTNYVDGKDRLWVESQNQNQISTRYENHRSDSDETLYGVENEKAKYSPNPRNININRQRSLSDSSKMNLNIPKLNQSGNGMRRRTTRQLEEDNDDYDEDDSNSTYSVKGGVFSQLLKLTGRTNTLSMKRRFSSKSGNGGGGGGGLNTSGPGLLPTMKSLGLKRLSSSTSTIVMNEEFDQDDPRVTGQKKKKNHRRNSLSDLPFMRTDTGDSNLTSGKRKRRASIQLHVADILTRQQFVLKLAKALMRFGAPSHRIESQLQATALVLEIDAQFIHFPMIVIASFGDMDTRTSETHFVKVTDGGLELGKLHKVHNIYKNVVHDEMDASEGTKLIHKLMKSPQEYNLWQRMLLAFLCSGLIAPVGFGGSLIDGLASGALGILLSFMQLHVASKSAMYSNIFEISIATVVSFTARGLSTTGIFCYQAVASAGVVLILPGYTILCGSLELASKNIMSGSVRMVYAIIYSLFLGFGITIGSDLFYVFDRNARIASQAATKAAQSYIEIQGSFFSNSDTFNSTAITGLPIPLFNGTFTFSNKSTDQITSNLNQGSIICVRDPNWPWWRQGMPQIYLILFIPIFSVLLSMWNMQPLRSRQLPVMCFICCIGYLTNALANHYIFDRSDVVSALGAFVIGVMGNIYSRVFGGTAFTSMVPGVLFLVPSGIAAAGGLAMTTNPHHSDSYSQGLVIGFRMVQVAIGITVGLFGSGLLIYSFGRKKGAALFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I794</accession>
    <name>A0A1B9I794_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_02116</name>
        <name evidence="2" type="ORF">I206_104582</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
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        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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        </source>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">CBS 10737</strain>
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    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <text evidence="5">Belongs to the ThrE exporter (TC 2.A.79) family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="ThrE/Ser_Exporter"/>
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        <property type="entry name" value="ThrE_2"/>
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    <dbReference type="PANTHER" id="PTHR31082">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR31082:SF4">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
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        <property type="entry name" value="ThrE_2"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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    <feature type="transmembrane region" description="Helical" evidence="7">
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        </source>
    </evidence>
    <sequence length="1121" mass="120343" checksum="24DCCCDDDC38FA7F" modified="2016-11-02" version="1">MSIPDNPFQAPTTPQAPVLQIHTDNASPTSPSPDAEHVLSSPYSHTSSPGPIDGSPHSGHISPPGQTTTSTPGGLAPPDSGIKNRRRVQWTSDSHIVQLHPIQPVPSSPHQLDEGNIDQFRDALEAHRNGSIKRTRPPSQLSRQSSADGSETRGGTEDEDYDYRLDVDPPLDRVTSAGSNPEEIEDNGMNEHVPTYIDPGERDGLPNIPQMSTQDEDHRDAAKDLVRAHTGKWGVLRRRVKTSGNINRAFGAGRLGATSSTTADPEKQDQDSRASQEAFAARYPEPRRHSLAASAAANGRGGAPAMPGGASVLSSLLALYGQQDGMQSGTTSAASSRPNSDDEGSSEDEAARRRSGEHHKGGKGFLGLGKKSASSSNSNGTPANEVAIHDEPHRASISAEATGEPLAPQPSRYSNGERPPPSPGLSGLFQRTKEQLQYKRPEAAKSGAGVFGALIQNTANLSGAATPAASALAPAAKRPGYQLNRYSAPNLEAEEGIKNWRPPSRPQSRAGSRGGSRPASVHSSTAVSQNGDSPSDDFSFKKKAISSDDLVGMRERERERQHTDDSSLTLNSKFNSSTMTLGDVKQNKRPKSGVGHLKLDSLAAFPVKTFKEGGKQIKSAEKWLMSAAKTPLRTPPEKGGMDYFTRPLTEDERRRKEWEAEKKRRKKAREARKKQEIFIIQHVAAILARQQFLMKLARALMMFGSPSHRLETQIQATAKVLEINAQVVYMPGTMLISFGDDATHTSETKFLKQATGLDLGKLLATHHLYWNVVHDKMSVEQASKDLDVLMTTPVYYNWWQSLLIGAMCSAFITVISFYGSFVDALMAMPLGALLVGVQMLAARNDMFSNVFEIAIATVISFVSAALASTEVFCYTALVSGGVVLILPGYIVLCGALELASRNITAGAVRIGYSVIYSLFLGFGISIGAVLYEKITHNDVLNASDYTCANTHGNAHWYQVTPSPYWYFLCCPGYAFFLSLRNQQPLWAKELPIMVVVAAAGWSSNHFSSLAFPGRSDMTSAIGSFVVGTLGNLYGRISNGSSFPVTVTGILFQLPSGLSNGGIFNFAAESSDGSSTAYSSGFSVAQQLVSVAIGLTVGLFVSAAVTHPFGGGRRRGAGIFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I7M7</accession>
    <name>A0A1B9I7M7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Leucine-rich repeat-containing N-terminal plant-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_02238</name>
        <name evidence="3" type="ORF">I206_104700</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012743.1">
        <property type="nucleotide sequence ID" value="XM_019154003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I7M7"/>
    <dbReference type="STRING" id="1296096.A0A1B9I7M7"/>
    <dbReference type="GeneID" id="30170607"/>
    <dbReference type="KEGG" id="kpin:30170607"/>
    <dbReference type="OrthoDB" id="2565197at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052595">
        <property type="entry name" value="LRRC69/RLP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48057">
        <property type="entry name" value="LEUCINE-RICH REPEAT SERINE/THREONINE-PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48057:SF7">
        <property type="entry name" value="LEUCINE-RICH REPEAT SERINE_THREONINE-PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="448"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF51524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC70749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="883" mass="98796" checksum="FA54373D78EBDC78" modified="2016-11-02" version="1">MKSIIPIQILFSILIFFIFEINALHIPKTSYNKINKVQSKRQLLSTSKRLLPIKRFGYFSFSRNPKTLPFWNPLEGIEGILIHHSIKGYKPKKRDLKLGFELKSIQDESFEKEESNGGIEEEYEIEERDDDNNELNCEDQQQDHLTTGLSSQFSDSIPSKEVKMAQTQLQLINYPDQLNNISNINITNIVDKQSNVNITDFSNRKYSDKILWSGFDNYQQLEERNLYKRHSDKSGSQEGYDDDSGGGRENNGGKKGSIESEGGNDNSDSNKHGGYGNKGNEDQWQDEGSKGDSGGKDNQGWKDTHNSHNGNGANHQSGYTNGKGTPGRHKSMSDDTSTSDDNYHEKFQQDWDASSSSSTNDKWDHEWDHEANSSGNSGDHDQDDNSNDDRGDPKHKYDDGQYHSANNDSESKGNNNWDDGQYHHSSTNEDDTNENGNWDQGGYHHWSDSQSQSQPNSQSTYDSKNDHQSDCSNLAKFYKSFEQSWIDDKGWSNDEILDCCQWSGVTCGSITKRVMGLNLRNNGLKGDLDNSLFDINGLMRIDLSGNDFKEVPDKFDGFTKLTHLNISNSNIIGRFPSSLRISPNLVNLDLSNNKLNGFIQFHHSTSLKSINLSNNQLTSFSIDIDSMDNNLNKIDFRNNQMSGPLPDLSGLKSLTSFDISNNNTGPLFDISNLTNLTRFDVRNNQLTGSFPILPSSIQSIFLSSNQFTGQIPSTIQSPENLINCYILPNNFICPTKDQINNINNNNSLFSKCHLHSCFSTNTKTIINNDQHNQNGTGTGTTTIINASQITSLNVPNGQKGIPVNPLPGENLTVPQNQLGQSKDQVVVAGQDYPGLSPQSQSQTQRLGSKTQLSSDGLQTMDVISSVVRIPGLIVFCGFIFWNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I8G3</accession>
    <name>A0A1B9I8G3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Haloacid dehalogenase, type II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_02598</name>
        <name evidence="3" type="ORF">I206_105058</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC71105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013101.1">
        <property type="nucleotide sequence ID" value="XM_019154361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I8G3"/>
    <dbReference type="STRING" id="1296096.A0A1B9I8G3"/>
    <dbReference type="GeneID" id="30170967"/>
    <dbReference type="KEGG" id="kpin:30170967"/>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF4">
        <property type="entry name" value="ACID DEHALOGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF51882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC71105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="253" mass="27624" checksum="C7738439319CFDA0" modified="2016-11-02" version="1">MTLSVCFDALGTCFTLQNIISAVDEKYGEDLAKNGWGSKGFVMDWFHSAQRDYTYLSLISSPSPPIASILKTSLPLSLSSAISIPPPSESEIEGITSKLSELPAAPTLKEAMTHLVNKGAKIAIITNGAKSTTESYAAKANISDVVKKVISCDDVGLAKPHKEVYESANQVCEEFEGKEVDKRERWFVAAHLWDLVAAKKAGFKTGLVLSEFPDELVDNDKQEESLQKWYKLYGGRPDVVGKCLLEVAQMITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I8W0</accession>
    <name>A0A1B9I8W0_9TREE</name>
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        <recommendedName>
            <fullName evidence="5">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_02673</name>
        <name evidence="7" type="ORF">I206_105131</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC71178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013175.1">
        <property type="nucleotide sequence ID" value="XM_019154435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I8W0"/>
    <dbReference type="STRING" id="1296096.A0A1B9I8W0"/>
    <dbReference type="GeneID" id="30171042"/>
    <dbReference type="KEGG" id="kpin:30171042"/>
    <dbReference type="OrthoDB" id="2562510at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050375">
        <property type="entry name" value="MFS_TsgA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702">
        <property type="entry name" value="L-FUCOSE-PROTON SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702:SF13">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
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        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
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            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
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            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
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            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="511"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="580"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="603"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="679"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="801"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="826"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="858"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="889"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="5">
        <location>
            <begin position="57"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="338"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="400"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="929"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
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            <end position="387"/>
        </location>
    </feature>
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            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
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            <begin position="432"/>
            <end position="444"/>
        </location>
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            <end position="462"/>
        </location>
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        <location>
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            <end position="939"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="OCF51956.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC71178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I953</accession>
    <name>A0A1B9I953_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endoplasmic reticulum junction formation protein lunapark</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_01321</name>
        <name evidence="5" type="ORF">I206_103679</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in determining ER morphology.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the lunapark family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013256.1">
        <property type="nucleotide sequence ID" value="XM_019153095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I953"/>
    <dbReference type="STRING" id="1296096.A0A1B9I953"/>
    <dbReference type="GeneID" id="30169690"/>
    <dbReference type="KEGG" id="kpin:30169690"/>
    <dbReference type="OrthoDB" id="1725934at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098826">
        <property type="term" value="C:endoplasmic reticulum tubular network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071788">
        <property type="term" value="P:endoplasmic reticulum tubular network maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903373">
        <property type="term" value="P:positive regulation of endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040115">
        <property type="entry name" value="Lnp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019273">
        <property type="entry name" value="Lunapark_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166:SF12">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10058">
        <property type="entry name" value="Zn_ribbon_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Lunapark zinc ribbon" evidence="3">
        <location>
            <begin position="256"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="147"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="315"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="316"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="347"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF52037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC69736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="402" mass="44434" checksum="187DC372B0B201ED" modified="2016-11-02" version="1">MGLFSIFRKSSPPDYETLLARLATEINEAKTHLSEIRLRERRVSLLINLYGISLWAIWVGLWWVNGLPLGLLGLSHHDTEGKVIGATGIAGAPIFIWGLNRLIHIWFARQRTHEETNLRLLLTKQRKHLEEIKKATNYDSTRKLIERYDDPSAVGNPQTPQRRIPDSPSPLPQGSGHGQTPASIGKGNKNVSGPASGPGGTPRAPGHFAGVGGTPGPNSNGPIIPVPQGLTPDQAAALSMQMHAIQPVLPTPEKRWYDRIADTILGEDPSHAAQSKYALVCGECFRHNGLIGSQYEWERMQWICPRCNHLNPPPISRNSSGESSILHNQPQIQQTPTKPIQPNPVQHQHHQQQRSSPRRRVNGDKSTPRSSRLGKEVFSASSSSDEDEPRDKSQEGMDVDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I984</accession>
    <name>A0A1B9I984_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin cross-linking</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_01443</name>
        <name evidence="4" type="ORF">I206_103553</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat coronin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013377.1">
        <property type="nucleotide sequence ID" value="XM_019153216.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30169812"/>
    <dbReference type="KEGG" id="kpin:30169812"/>
    <dbReference type="OrthoDB" id="347435at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF20">
        <property type="entry name" value="CORONIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16300">
        <property type="entry name" value="WD40_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01167">
        <property type="entry name" value="DUF1900"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="423"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="848"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1303"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="438"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="465"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="864"/>
            <end position="907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF52158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC69610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1361" mass="151190" checksum="BE41A443F236FBB5" modified="2016-11-02" version="1">MAGRFGASKYRNSLIHYPTREEYYRKDLPQLTIFSGNHFDNEIKSNRQWIVTLTSSGELTYREYKNDLNEEEEEMVGHARVGNGSITSWDLSKLEDGTMAIGNSDGSISIYTLPESSSSSLIARHTIPAQSASPITHLHLHPTTPNILLVSSSSRPLTIYDTSSSVPKARISLNLNEPKGIWSIGWSTDGTKLAILSKSGNLIIFEPRKSNEPIITKSLVSLIQPLKPCKLIWINENIFITSFSKFRNRQYSLFSSIGKLDLIFNQILDTNSNNLLIPLIDKERNLIYLIGKGDLILRQIEISNFFQNGFQESIHNLNLPLLNSSIIINNNGINLLNVMKTEISKIFLFTKDKDGNCLIPISIRIPRKQLIDFHSDLFPDIIGTVPEQSAEQWFDGKDNLPLYISLDPSKRNIWEDRIKAYKEKTTQAQSAPDPVKPKSTSNPLNGTDQSSPTSLPAPTVTVANSESPSTEPTTSPPTQIKETFSNNTDLPALLKDEDYSSTSYKSRIVADYLAEEFERHKSDAANGPLFVGLQGPQGCGKTTFCSGFVQYLKQKKGLTAAVLSLDDLYKTHQGLKDIAAKHPDNALLSGRGPPGTHDVDLALSVIEQVKHINNTPGRPVNLPIFNKSLCDGEGDRSDSTVKINGPIDVFILEGWSMGFAPLSESALKAAYDNPTPASTQTTDIYYTRHTLSSLQTLNTYLSEFAQAIYPTFKAFIQVEPLSYDYVFKWRLQQEHAMKSSNGGKGMTDEQVQRFVERYMPGYELWKEGINNSGTGWEGRGLKLIFGSEREILDIFRPATIPIDKANEVKEEEKGDIQLKQVQKIAEEKTITLKDKEVPVQVEQVGKTEITPFPPLTQPEAKPVSTESAASPKPSLQASQPITATSNLRQKASANTQAPPNERYNPNWSRKFLAGKSPLIPTYDALPPIQTLHQDSRILKSNSRLAFFPIQGTGGRLNVHPLSKKGRLSVGGEGYLSAGVEIVDFDVELAGDRVAVAGEDGLIRVWTVDSKGIEGVGPEADQILKGKGIDKITQIAFHPTAKDLLVGLTNDHGSSFLRFWDLSKREEVKTAEVSPHGAFNFSISPEGSRVAIATKDNQILVLDPRSSDNVKSGKAHDSPRSFQIAWIDANHVVSVGFSRGSQRKMNLYRIGANIEIIYSMTIDVSPSVLFPVYDPDTSILYVWGKGERVIQTYEIQLSNTEPITKLPSHTASSPQIGLIFQPKRIVDVKKVEIAKCLRLTSKTLEEVTITIPRNKPEFFQDDIYVSTTDVETYVCSASEWLEGKDEPLKKIDLRPEGMISLSQAPKMNSSRTKKFVPAANVMSEEEKKRQEMDALFAKAKMDESSDEEEIAQKGLPPPDDDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I9Z3</accession>
    <name>A0A1B9I9Z3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lysine decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_01704</name>
        <name evidence="3" type="ORF">I206_103290</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013634.1">
        <property type="nucleotide sequence ID" value="XM_019153473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I9Z3"/>
    <dbReference type="STRING" id="1296096.A0A1B9I9Z3"/>
    <dbReference type="GeneID" id="30170073"/>
    <dbReference type="KEGG" id="kpin:30170073"/>
    <dbReference type="OrthoDB" id="414463at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.450:FF:000045">
        <property type="entry name" value="Lysine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00730">
        <property type="entry name" value="Rossman fold protein, TIGR00730 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31223">
        <property type="entry name" value="LOG FAMILY PROTEIN YJL055W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31223:SF70">
        <property type="entry name" value="LOG FAMILY PROTEIN YJL055W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102405">
        <property type="entry name" value="MCP/YpsA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF52415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC69351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="526" mass="57449" checksum="C4BCA5194FD318D9" modified="2016-11-02" version="1">MSVPSPFPAQADLKKPVCVFCGSSPGNQPLYTNASAAVGQALAKANIPLVYGGGRRGIMGVVSQACLQAGGYVHGIVPQALTERASEHTPAPGTSSGSQSKEGQGEDVLGDGFGGTLTTDVVGSMHERKLKMARLSQGGFIVLPGGYGTFEEALEMITWNQLGIHRLPILILNIGNFYTHLYNQFLSSVEAGFIAQSNLSLLKLVNLEGGESANADESQAGDWGKAALKALDEWDLAEGTGYSLNWDLKERRAGGDESTLEAESSLVKAPESIFTTLRYTSPRNIPTLPIRQDSLPLMDLHFERLKEAFEYFTQRDGQERWGVWPGEDVIWQSLQKALEVKERAGAGDYRVRIVIHPGGKVDVQCPDAPKDAGPFAFLPSASRSAIRRPVVFDQEITDISLESSDQIDLRLHKTTNREMYDEAYARGQTIVPSNIHPEVILHDGINILETTTSNIAIKCSNSDEWITPKLNKNQPFLNGVMRRYLVAKGIIQEGEVTIDMIRKVKSENGRLIGFNGLRGVWEGEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IA20</accession>
    <name>A0A1B9IA20_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial inner membrane protease subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I206_01752</name>
        <name evidence="14" type="ORF">I206_103242</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S26 family. IMP2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013681.1">
        <property type="nucleotide sequence ID" value="XM_019153520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IA20"/>
    <dbReference type="STRING" id="1296096.A0A1B9IA20"/>
    <dbReference type="GeneID" id="30170121"/>
    <dbReference type="KEGG" id="kpin:30170121"/>
    <dbReference type="OrthoDB" id="308440at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.109.10:FF:000005">
        <property type="entry name" value="Mitochondrial inner membrane protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037730">
        <property type="entry name" value="IMP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041:SF2">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 13" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Peptidase S26" evidence="12">
        <location>
            <begin position="23"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCF52462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WWC69304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="190" mass="21353" checksum="878F2BF6C01B029A" modified="2016-11-02" version="1">MSKAGSFFRQKGVKDAFRVLAWVPVGIFFTRHIYSLASVTGGSMQPTFNPNLSSAPLHHDVVLLERWSVAISRFRRGDVVTLWSPQNPELLTTKRIIALEGDLVNPLPPSPPTPIRIPPGHCWVEGDSKFQTRDSNTYGPIPLGLITSRVAYILWPWPRRGIIDNQLPTKSKDRVKSLGQTFLQSRFGEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IAQ4</accession>
    <name>A0A1B9IAQ4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PLD phosphodiesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_01932</name>
        <name evidence="4" type="ORF">I206_103064</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013858.1">
        <property type="nucleotide sequence ID" value="XM_019153697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IAQ4"/>
    <dbReference type="STRING" id="1296096.A0A1B9IAQ4"/>
    <dbReference type="GeneID" id="30170301"/>
    <dbReference type="KEGG" id="kpin:30170301"/>
    <dbReference type="OrthoDB" id="9997422at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030572">
        <property type="term" value="F:phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00138">
        <property type="entry name" value="PLDc_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21248">
        <property type="entry name" value="CARDIOLIPIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21248:SF22">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="294"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="601"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="671"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="671"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF52639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC69128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="709" mass="79303" checksum="4BDF6D3F91601215" modified="2016-11-02" version="1">MSNAVPQAPMAATNQGHVSSNQEKSLLSGHIASLLNPDSPTITSTLASSSPETSVREVAERLFGVHRDHGHHSHHLSDSQDVHGSNENEEGGMEKLMNKLHLKKREDTDEGIENPAEKQWRSMKLLNQEEIEEFKQFGQWGNETPSDLFLNIYAQSLLPLNTDPLKDLVSPSLIGSCGVIPLSIISVIPDIIEHHADIIVRAQHEIFLATNFWEASSAAKTITDAFKELSRRVIERKGKKVVIKMMYDRGNPQQVIDPHQSVDVKTYTGDKVKLPLPEEIPGCTLEVQNYHQPPVGTFHAKYMVVDRQIAILNSNNIQDRVNVEMMTHIEGPIVQSLYDMALISWWKSFNPPLPLIGVPPIYDLARGKDAYEFGTDHPVISTKGDLNSAAEQSRKVLADHHAQAVEEEDGKKEIWDKDNQNEADRVDNQFTSEESINKHLNSCILIDTGNRVDSTDNNPPPNASAFRPVVLHSPHNPFPIAMVNRPPRGRPGHGDVFVPQDQAWLAGFKFAKKNVFIQTPTFNALPVVEAALDACRRGILVQIYADLGFNDEGELLPFQGGTNQMVATDMYSRLSDEYKKNLEIYWYTGKDQKTPLNAMKKSRNCHVKLMIVDEEIGIQGNGNQDTQSWFHSQEINILIDSKIISKEWREAIDSNQNTLHYGKVSQKDGIWRDENGKTLPGEKKPPKGPMKSLVGVKGAIQRVRGEGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IAY1</accession>
    <name>A0A1B9IAY1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="19">AFG3 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">I206_01884</name>
        <name evidence="20" type="ORF">I206_103112</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="20" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013810.1">
        <property type="nucleotide sequence ID" value="XM_019153649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IAY1"/>
    <dbReference type="STRING" id="1296096.A0A1B9IAY1"/>
    <dbReference type="GeneID" id="30170253"/>
    <dbReference type="KEGG" id="kpin:30170253"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005745">
        <property type="term" value="C:m-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000019">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
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        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AAA+_ATPase"/>
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        <property type="entry name" value="AAA_lid_3"/>
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        <property type="entry name" value="ATP-dep_Zn_Metalloprotease"/>
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        <property type="entry name" value="ATPase_AAA_core"/>
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    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
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        <property type="entry name" value="FtsH"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="Peptidase_M41"/>
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        <property type="entry name" value="Peptidase_M41-like"/>
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        <property type="entry name" value="FtsH_fam"/>
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        <property type="entry name" value="AFG3 LIKE MATRIX AAA PEPTIDASE SUBUNIT 2, ISOFORM A"/>
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        <property type="entry name" value="ATP-DEPENDENT PROTEASE"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="364"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
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            <begin position="1"/>
            <end position="143"/>
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    <feature type="region of interest" description="Disordered" evidence="17">
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            <begin position="204"/>
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    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="772"/>
            <end position="821"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
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            <begin position="117"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="206"/>
            <end position="217"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="792"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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            <dbReference type="ARBA" id="ARBA00022989"/>
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    <evidence type="ECO:0000256" key="14">
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00382"/>
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    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OCF52591.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="WWC69176.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="821" mass="88115" checksum="05A08CEB30BC58B3" modified="2016-11-02" version="1">MSIRAISLRRLPRQSSSILRPLLSRSYATPQSPKPSRNAPPPSGLEGLFGGSGKAGTTVAPKPPGSEPPSGPSGPKNPEGGIPSEQLPEDQREPAGSEEPKRHKLSEQIGGKAGKKIGTGGNGGGSGGSGGPSGGPGMPGGFGGMTPNQLLLAALSTYALWSITQPDDVRTKEITWQEFRNSLLARGLVSSLEVVNRSKVRVHMHSPLNSSQSPQPNATGSSNLPSPDHGPAPYSFTIGSLEGFESLLISTQDELGIPAAERIPVSYREEISTFQTIMHFAPTLLIAGLLLWMARRGGSAMGGGGSGGGIFGVGKSRAKMFNKDEQVNVRFKDVAGMDEAKEEIMEFVKFLKEPAKYEKLGAKIPRGAILSGPPGTGKTLLAKATAGEAGVPFLSVSGSEFVEMFVGVGPSRVRDLFANAKKNAPCIIFVDEIDAIGKSRGKGGSFGGNDERESTLNQLLVEMDGFGTNEHVVVLAGTNRADVLDNALMRPGRFDRHIAIDRPDIGGRRQIFGVHLGPLTLSTDLKSEKIAEKLALLTPGFSGADIANVCNEAALRAARRGGESVTEDDFDGAIERVIAGLERKSRVLGKDEKKTVAYHEAGHAVCGWYLEHADPLLKVSIIPRGVGALGYAQYLPKERFLFTTQQLLDRMCMTLGGRVSEEIFFGKITTGAQDDLQKITKMAFEVCANYGMNPEIGPISYGGRDQQSEGFQKPFSEATAEALDRAVKKMVVDAHTRTTELLSKHKSDVEKVAKLLLEKEVITRQDMRMTLGPRPFENKDEMDDYIEAQLDNIHKEKKEQESQDGPTPQLAYKPIDINKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IBJ1</accession>
    <name>A0A1B9IBJ1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_00323</name>
        <name evidence="7" type="ORF">I206_101003</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014241.1">
        <property type="nucleotide sequence ID" value="XM_019152103.1"/>
    </dbReference>
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    <dbReference type="STRING" id="1296096.A0A1B9IBJ1"/>
    <dbReference type="GeneID" id="30168692"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000832">
        <property type="entry name" value="Serine/threonine protein kinase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="334"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="133"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="246"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="773"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="828"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="926"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1038"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1161"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1218"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="773"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="828"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="879"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="927"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1038"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1071"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1161"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1220"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1240"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCF53022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC67096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1276" mass="136780" checksum="41B453F92C99FAC5" modified="2016-11-02" version="1">MNGSPSLASPIPTLPNQSPSPSPRRGAGAVAGPSSPRLPRVSMGPRLPSISASQPFDFDRTESPPLPGTSARTSIVMGFSPASSHQTLTAVPEASSSTSPRNPVLTLNTSNRRLSSLSPQLTTPVEQVFQWTEGSPRPLATSPRGLASEFPPRSRRNSAAIVSISLSSRSRSRTPRGSAAVLPGQQGNSGTGTPNKGSSSATPKGDGQVVQMGDSWISGQDQEELDDWQPAGGMLLDGDETAVVGDEDGDEFDDDAKGRSWTGYSDEDGSDSPHVEEPFKPGMLIGEGMQFQGEVIVPAVGRMGTDDVGLPLRRGGSEATKNTRTDGKTEKKRYEVVRKLGTGSYAVVYLVREKGGRHREFALKCLSKQDLEEEQLETQLFEAHIHLSLPIHQNIVTLHQTLQTRKWLFLMLELCPGEDLFYWLEKSRDASPHAQPVPLPGDRNGGVMSSSKLSSSSIPFSSSQMFSNFNGMSSSFTNSPGNAFSQFSGSPASLLFAHHNGHSHSSHFTPSQTPPTPSLLSAFSANTLLSSRRLRLIASMFSQMCEAVSICHDAGVSHRDIKPENFICCDSIELEAATEGDYGEDEEDGKPVNFGPQAKRKVVVKLTDFGLATTEEESGDVECGSKPYMSYECRNNLGPTYFPAPADVWSLGIVLINMLFHRNPWKDPTPGDPNFDNFLMDPIGFLLTKFTGIGGEVASYLADHVLCIDVDARISARAFGQWIKNLPEMIAGRKAVQSLRISRLETQKTPTDKGLFVKSPVVTTQEATRKYSASALTSSAPTLSNLPPPSQLSQIEDHHYKIVEEENEDTSPTTPPLDHDQDELVSATTVDEQLTPVDTSEYASPENEAIDNDSEIYVNESVADGSERADANSRSLSTNKRRKRGVRKGKAAKAAALAAAGAEQPSQEERDALLAELTAASQSLAREVSKFSKDGDSSTPDLSRMEDFPPLGATPAQIAEAKKSKWKDMMKFSGNQNTELAALARRVAERDGSLNLSAPAKLQHNKYNSPMTSATKHALRQTTTVSTTSAFSTTSALSSFGGVSSATSSADDEDWRKPRTVKPQAILEDQSETRGRDKTVTHAGRRGEDQSRARKAALAAAAITGGFSEMGNFGKPSALSLSQPIAAPARPQDPRPQAAYQGNPIKHSISANAVPTNYTIRNSAPIGQSPITNQGKAPYKSGLSHTHAISMDGSSPNTILDNSSFTTDNSTRNAYARPVLSSKESSSTITSPSLITAASNNVTSPTSGAGPNKPKLKGQIHTLAKMLSGLKTKGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IBP1</accession>
    <name>A0A1B9IBP1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_00174</name>
        <name evidence="6" type="ORF">I206_101152</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF52874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014093.1">
        <property type="nucleotide sequence ID" value="XM_019151955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IBP1"/>
    <dbReference type="STRING" id="1296096.A0A1B9IBP1"/>
    <dbReference type="GeneID" id="30168543"/>
    <dbReference type="KEGG" id="kpin:30168543"/>
    <dbReference type="OrthoDB" id="19711at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050995">
        <property type="entry name" value="WD-F-box_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604:SF4">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604">
        <property type="entry name" value="WD40 REPEAT PF20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="64"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="468"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="518"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="701"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF52874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC67245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="788" mass="89053" checksum="54F28D5B73695879" modified="2016-11-02" version="1">MDSSLKPKVSIPTQRHLDLQEELLKNALNLPLEYKIDLVNKLIWSLPRNEISNLNEKLNGVLQRDIIGSLPPELGFLILSKLNFEDLLNCSLVSRKWRNICEEQALWALLCANHIPPIRSSNPSWSDISTARSILLQSKNINSEKEEEEEEEYDNDRFYNSGGMGGGGGLDPLIMKSGLRRNVWERQGLNFVDSSLPKHIIQFNSLKIESELESINQNQIKKDISPIKSYLNIPSIKPKVNFKHLFIINQIIKNRLLFNNNNCNDDENKNLIKPKTIDTFSSIKNGGLPGHSEAIYSLTLINHEMKFNLNQNCKECYNKPSKNSFTNLENQNENQFDFNSTLNFNINNNNLLPKNIVKGKEWLLSGSRDKTLRLWYIDNQEPPKVIKIFKGGHSGSVLTHAIVKINLFSEKDEKKSISSNNNKGINNLTSFEENLKIKQVKLIAISGGSDGKICLWNIEGSSFPEKVIKAHEDSVLCVRADERYVVSCSKDKTIKLFDIQTLEEKLVIGPSNGIEDDDQFHRGAVNAVGLSEDYIISASGDKTLRVWSIYDGQLLLTIEAHSRGIASIDFSTALTSCVPILNENEKWKGSIVTGASDASIKTFQLIEKKIKISNHLEENMNLNQDQNHSISTSSLNSFSMDQNSGNVKITYQAITNKGTIISMKEDYEMFSPCICPPGLHRPPLEFINLNNNNSRCKRCGNKGHTELIRTVNLNEKIIISGSYDSKVKVWDRLTGKLLINLSNSHTGRIFSVISDKFKIISSGLDCRINIWNFAYNLDTSFIEQDPLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IBT9</accession>
    <name>A0A1B9IBT9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_00360</name>
        <name evidence="4" type="ORF">I206_100966</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
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                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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                <person name="Birren B."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
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                <person name="Dewar J."/>
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                <person name="Griggs A."/>
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                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
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                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
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            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF52890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC67228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="891" mass="95495" checksum="BC9175C1766943B9" modified="2016-11-02" version="1">MYTGTHQRTGSNPRTYGAQDITSLNGRRDDGASQSMYSGSGDDGYNAYSHAGYGGMSSVGGYAGYSSGMSLGGYPATSSSPSAPSGSRRTSGPKLATPPQASTTTANPSPSSRYYPSAQAQPADQSPYQPSSAPPQVSSHHHSSLSGQPQTAHPYPGQYQHYYDQQGHQNSSQWASYPSASAHSYASQSAAPRNNASQATTTPTMPQSATVGDTHHRSSASSGLYDYPTASSGYQSWPTHEQSRSTSGQQQAWQQQASASSRQSQTQSAQPAPMPQGAWQGYGNHPSMSHTMPPQHMANPQYGWQPQWNGQQYGYPPAPVHTQSGHQAGQALPATSSAAPLYPKEKKPKKEKKEKPPKAEKPPKEPKAPKPPKRAKHEIPEGYAGLGKRLMESSTEEEVEVKKDGRGRKKGKKDEKEKEKVPKAHPKSHLHPPRQAQSAWQLFFTDELNKAKAAASQGNSPGGTPHHAKLNVAQIAKDAGIAYATLGEDQKKYYAQKVQESKEQYIIELAAWQATLTPEDIKAENAFRAQQRKEGKSRKGNLKDPNAPKKPLSAYFLFLKGIRENDDIRAKVWGEESETTKQSVLAAEKWRSLSDDEKKPYLQQAENDKQEYEAARKIYEDEAAARARGEDVPRRPPAIPESSTHPAPAPTSLLRDDVKAYNPADHTSSDPVKPSSPAGEGVPSSDNNFAGFESNPDHPGSSDHTPAHGSGDFELDDFKGFTDPLQDMDLAGLEGITTNTADNNEPQWDELQKLMGTTDDGYDNSSAEDKPAAAEIQGETSDVAGVSIAPSLEEAQASNDAQNVGALQSEAQVQDLATQAEGVSVVPQTLPQTNQEGSGVPTEEVNELPPAGVPIADDADVPTEVPTALIGQENAQPTTDVLGSGPVVDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IC86</accession>
    <name>A0A1B9IC86_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alternative cyclin Pho80</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_00338</name>
        <name evidence="3" type="ORF">I206_100988</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014256.1">
        <property type="nucleotide sequence ID" value="XM_019152118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IC86"/>
    <dbReference type="STRING" id="1296096.A0A1B9IC86"/>
    <dbReference type="GeneID" id="30168707"/>
    <dbReference type="KEGG" id="kpin:30168707"/>
    <dbReference type="OrthoDB" id="337735at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20558">
        <property type="entry name" value="CYCLIN_ScPCL7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF117">
        <property type="entry name" value="PHO85 CYCLIN PHO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="320"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="434"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="528"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF53037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC67081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="622" mass="66896" checksum="2C6187C06B5C25AB" modified="2016-11-02" version="1">MSITDPSSSSSAGPSSFREPIIGPPNPQNPPLLPWAFSDCPLDILVDLLTHMLELLIKHNDQVVLTPDALTRFHSRAAPGISVKDYLGRIVKYTNLEKIPLLSLLAYIDTTCNNLPSFTLSSLTVHRFLIASVCAGSKAQCDVFCTNAHYAKVGGIKTQELNALERELLRVTKWDLCCHAEQLQKYYSSLIRSHGGYAQAPQPTSPPFLPFPRSRSKPRATASPTPEGSVPPGEPEPPDEDDAMGEAEEEYGVEDEDLGITDSERRNGRMAFDSTDSPTETSRGRKRNRERRASNGNMDIDVDPSSTGSQPVDIVEEEGSPYSNASSSVPSSSKSSIHRVGSIGSGSLRGKRRSRLVSISESRIAEPKIDTTQATASPSTSSHDIKGINGSASGELSRRISHSESRRHNEIPPTIPKPAPIPTPAPTRKSLQYSQSHSAISPPSSTPGSHDPKSHSHHSGKLLKSLVGGIFRRKSTPGESVDLIQQISPSSTPDNGLSNLASKQKSSNLGIPSNSIQNSTTILNRSNPPTSGITSSRPISTSPRISTSPRMYSPNLTISHTPKSPKPGLAKPVTPKVRTRDETSLEPKDRIALNAPLSMSLGMGGMEMSMAANDDGTRSRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IC99</accession>
    <name>A0A1B9IC99_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_00586</name>
        <name evidence="3" type="ORF">I206_100741</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014504.1">
        <property type="nucleotide sequence ID" value="XM_019152366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IC99"/>
    <dbReference type="GeneID" id="30168955"/>
    <dbReference type="KEGG" id="kpin:30168955"/>
    <dbReference type="OrthoDB" id="10588183at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF53285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC66834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="470" mass="52981" checksum="E19131B860042A1D" modified="2016-11-02" version="1">MPGRFLLARAQSHFTLGNLSKDDKSSGKPVRPSLAERSLSDSSITKIACTVGPSELRSVINPNWKEREKKDRNVHQLRCNTLMNQKKLVQAEEELLAYEEGDGDLEIPFELDETLATSSPSHSLLTTPTFPYSPTTMTPLEFSTSFSSSCECSIECIDPSLCNSSFISIGSSYRDFNSQNIQFSTNSSNCFSNNNNSNRRRQKNPPIKFSSPLTNRTFHLSRKNSSSIVGESSSSTTKLQVEEIIQEKCSWATSPQFLNFSNYNSFNMNMNNDNQLNLRRNYYEEEEEEQVKSFSPNSFAESLNSNSSLRSTRERRESEDSTYSGENEFNNEKDLSNILENCGSLLQQDDDENHFLKNSINNDNNSFKISSLSLSPITINSFDKKSSSFSLSPILISEFKNNDKNKNTDSSFLSIHSPRSDENTIKSIGFNAPSLSQFQQTHLDLPKQSIKSSTSSISQQRKLSTIIEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9ICH1</accession>
    <name>A0A1B9ICH1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I206_00458</name>
        <name evidence="14" type="ORF">I206_100868</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the histone H2A family.</text>
    </comment>
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        <property type="protein sequence ID" value="OCF53157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014376.1">
        <property type="nucleotide sequence ID" value="XM_019152238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9ICH1"/>
    <dbReference type="STRING" id="1296096.A0A1B9ICH1"/>
    <dbReference type="GeneID" id="30168827"/>
    <dbReference type="KEGG" id="kpin:30168827"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000021">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 9" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="11">
        <location>
            <begin position="13"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="12">
        <location>
            <begin position="100"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCF53157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WWC66961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="139" mass="14736" checksum="25D7671B0EBE7910" modified="2016-11-02" version="1">MSSKVTGGKGGKSKTSSETKTLTSRSSKAGLQFPVGRIHRFLRSKNANNVRIGAKAAVYVAAIMEYLTAEVLELAGNAAKDLRVKRITPRHLQLAIRGDEELDLLIRATIAGGGVLPHIHKSLVAKQGAGKKVKLTPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9ICY0</accession>
    <name>A0A1B9ICY0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_00810</name>
        <name evidence="3" type="ORF">I206_100517</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014724.1">
        <property type="nucleotide sequence ID" value="XM_019152586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9ICY0"/>
    <dbReference type="GeneID" id="30169179"/>
    <dbReference type="KEGG" id="kpin:30169179"/>
    <dbReference type="OrthoDB" id="2573753at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="39"/>
            <end position="102"/>
        </location>
    </feature>
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        <location>
            <begin position="115"/>
            <end position="233"/>
        </location>
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            <begin position="280"/>
            <end position="323"/>
        </location>
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            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="310"/>
            <end position="323"/>
        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF53505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC66614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="323" mass="35158" checksum="A08C3193684F07C9" modified="2016-11-02" version="1">MDEDLQLNRGMFACFPCVILWRWAQKKLTKYDPEREPLFPSPQTILTPPTKKHRPNLPNLSSSGSVPLWSSAPTSPTKSGMGYFSDGKRNGSTSRLSQEGRERLGSISREYGGRMQSLYPSTSTPSTPSFPSTPHTIGRSSIRPLSSINPIVATEPTSPNRPSAPNLGRSASEPRNLSDLGFAPQQIPAFGSISVGRGGRTRSFTLSDRSPLSLGEGDEKNVRRGRSPGPAVFSRLNDIQNQLNDPIEENNSKEASRIINSSIERCSSHPQLTTAISVSGHTDDNIITPPEEDVVRKELGLRGLNSVRGKRGEGKGGKRVKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IDG4</accession>
    <name>A0A1B9IDG4_9TREE</name>
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        </recommendedName>
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        <name evidence="20" type="ORF">I206_00891</name>
        <name evidence="21" type="ORF">I206_100436</name>
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    <organism evidence="20">
        <name type="scientific">Kwoniella pini CBS 10737</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="21" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ergosterol + NADP(+) = ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16933"/>
            <dbReference type="ChEBI" id="CHEBI:18249"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.71"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:18503"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="15">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.71" evidence="16"/>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014805.1">
        <property type="nucleotide sequence ID" value="XM_019152667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IDG4"/>
    <dbReference type="STRING" id="1296096.A0A1B9IDG4"/>
    <dbReference type="GeneID" id="30169260"/>
    <dbReference type="KEGG" id="kpin:30169260"/>
    <dbReference type="OrthoDB" id="5326588at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000246">
        <property type="term" value="F:Delta24(24-1) sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000003">
        <property type="entry name" value="C-24(28) sterol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF31">
        <property type="entry name" value="DELTA(24(24(1)))-STEROL REDUCTASE ERG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01017">
        <property type="entry name" value="STEROL_REDUCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OCF53586.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC66533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="495" mass="57157" checksum="57A775C63B27F987" modified="2016-11-02" version="1">MAVTMDGPSTNLRKRKSNGNLNSDNIMNGKSTALLKINAMPTEHGQEMDKKLDEHQEYEFGGPVGVVAMMVGFPLLMYYLWICLWFYQGKFIYPTSINDIRPFFNKMGQHIYEGAYPTKFAWGTYCGLTAIQLIFAQVLPGLTQNGLPVPSLGYKALPYHCNALYSWYATLALSYVFHKTGIYRLPWLIENYGQIMTVALIVSFSVSILIDVCGRLFHYGGKPMRLSGNIIYDHFMGITLNPRLGRIDLKMFAEVRVPWVLLFLISLSGVVKQYEELGRVSYNMWHMLLATGLYMNACAKAEHMIPQTWDMFHEKFGWMLIFWNMAGVPFTYCYPTIYMARASPSTYEFPLWGNIAMFVTLVTFYYIFDCAMAQKSNFKMHQQGEHNPRKAFPVLYGSDLKNPSYIQTKHGNKLLTGGFWRYARKINYTADWIQACTWGLTAGLNTPITMFYPIFFLAVLTHRCGRDFAKCSVKYGEDWDEYCKVVRWKFIPYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IE31</accession>
    <name>A0A1B9IE31_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_00825</name>
        <name evidence="2" type="ORF">I206_100503</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
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    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="kpin:30169194"/>
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    </evidence>
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    </evidence>
    <sequence length="223" mass="25057" checksum="64960BEA96B25E9F" modified="2016-11-02" version="1">MSEQERWAMVDASEFDNRLRESVTNDWPTFARPFFPEHAVSTKTPVASTTNLLSDTLGGATSGSGQELDFFPAFEGAERPTNKSVPDITMPTEGRWRDFDAHVRSYRYFTDSDSVPLSCILVEHGAPVIREFQASCGRSDCEWFKIWEDYWHGESPEQQDAEEKYNQLMRDQAISLVSRCASLNVDRSSDPATRVPLNIAWGGFLGHEHPAESTKSSGVDTPK</sequence>
</entry>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
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                <person name="Dewar J."/>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8KZK1</accession>
    <name>A0AAJ8KZK1_9TREE</name>
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        <recommendedName>
            <fullName evidence="15">ERCC4 domain-containing protein</fullName>
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        <name evidence="16" type="ORF">I206_100683</name>
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    <organism evidence="16 17">
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            <taxon>Agaricomycotina</taxon>
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    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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    </reference>
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        <property type="entry name" value="XPF_nuclease_EME1_ascomycetes"/>
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        <property type="entry name" value="CROSSOVER JUNCTION ENDONUCLEASE MMS4"/>
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    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
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    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
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    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="WWC66778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="593" mass="66175" checksum="CAA8ED9F018F6E37" modified="2024-07-24" version="1">MPSDIVVISDTEEVSDEEIAFVGINQIQPKSRINQAGPSRPNQVPIFIDSDDEPESTDENGDQDIFTFLSSTIDIDNPVTRSTNISAVKSVSQAIKVTNKDRKGKRKAEGVDLLEAKALMEEFQAFENSISKSSIISKLDAITSEIPSETQLKSIEDEDIEDKTKKKPKKRKSSANGDDAGSQMRQRSTTAIDGGSVPPKSTLSKEEKEALKAQEKAEKQFQKDTAKAAKEAEKSYQRKLAEVNRLRSSKSDTVREIHLYLSSDLSHPKSPISGALPEIKKKMTDNFSELHFLHEDQSPICGVIKFKRHLKARWDSEKKRFIPLEEPKWVWEGIILVLVEAEEIVDKISTSSNVLGDDAILNEKEDLSSWVSDIRLNLNLKKDDQVIIMIKGLQKYYSKTKSLANKEFTAAARAGLNGSSSTQGGSKSITLPTRPEKEIIEMALVELQVKERCFLVHVEKTEDIEDWVYNIAADVAIRPYKLISKSHLNFCPTDGIRKSTNPTETFELMLQEVTGITPSASMGIASEYPTFRDLMESFEKAERRGGVERAEGMLADCEIKTLRNGTANGRKLNKALAKRVYNVFRGEDSLALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L2A1</accession>
    <name>A0AAJ8L2A1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_101955</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC68036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058581.1">
        <property type="nucleotide sequence ID" value="XM_070202480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L2A1"/>
    <dbReference type="GeneID" id="30175323"/>
    <dbReference type="KEGG" id="kpin:30175323"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015355">
        <property type="term" value="F:secondary active monocarboxylate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035879">
        <property type="term" value="P:plasma membrane lactate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000340">
        <property type="entry name" value="MFS transporter, SHS family, lactate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="457"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="85"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC68036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="531" mass="58384" checksum="5CF68F3268E4C054" modified="2024-07-24" version="1">MSQFDPHVEGAYPKDHVSEDYTFNNQHRHSASVKDQLATWHANRGDRSFVRCMIPSIRGTPPGELPTTKNPIKLFRMVSPFAWLMFFSGWLAWTVDGYDFFCVSLTLDSLADQFKVKPAKITTAITLTLLFRSLGAVIFGILSDRYGRKWPLLYDRYLGSQWEISVYSLFQASQDADIGASLRVWGAASQTALENVPADARGLLSGIMQQGYAVGYLLAAVINLTIVQYSKPHWRTIYFFGAGFSFLAACIRASLPESRQFLLAREEAKARGLTAKETTKNFIQELGTMFRTNWLRWIWAVCLMTFFNFFSHGSQDLYPTYLKTTKKLSPKLASKATIISNCGAIVGGTIAGYSSQYVGRRFAILICAFWTAAFLPLWILPKSFGGLAAGGFFVQAGVQGAWGVVPIYLGEVSPPAFRALFAGLSYQLGNMASSGAAQIEATAGNSLKLAGTNIPDYAAITGILLGAVIAWGIICVICGPEADGALFEQAKVAYQRGGGEADPTELFNHDKPDHSHIEKTMAIEHNENELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L3P1</accession>
    <name>A0AAJ8L3P1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Velvet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_102690</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058706.1">
        <property type="nucleotide sequence ID" value="XM_070202605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L3P1"/>
    <dbReference type="GeneID" id="30171412"/>
    <dbReference type="KEGG" id="kpin:30171412"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF3">
        <property type="entry name" value="VELVET COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="6">
        <location>
            <begin position="95"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="180"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="353"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="476"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="286"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="378"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="434"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC68756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="639" mass="69687" checksum="226044788D7DC777" modified="2024-07-24" version="1">MSRPQSISPSYRATPISQSAAPPSHAKKRRRSEKDRTPPRAIYPGEGRASGSRSPPTIHQDHEESYDDDEWEDESYSHKKSQASNVPRRFTGEGQEGWTYHLEVIQQPQRARACGFGNKDRRPLSPPPIIRLWIRTASGAVVDPSTIDPRFLILMVDLWSADRQQERNVVMHPVSAGVSRLESPSLNPADLAPVAGPPSRPSTGTSRPMSGSSAGISSWSSGSWRQPTYQSPAPPPHVAPYPHESPKPPYPRDSLLASPANVRSPYPNWSSSRSPPLPPPFHRTKSYGDKKIEHAPDPPRPKTAPSPQHPLQQQMLATSPAHSVGTPKSQISLPPLSSIAEERPSTAAGLTLPALHAKDQTPYRPSSSSSSLWGRPRTALTDASTAATDYTVGTRPISSSSSNWYPPSEYDRNKERPTSSWSEMRPWSSGIINSVSRPSSSAGPVSSIGTGMAPPSPHSAQFAYSGRFVDQQWPLTPGNIGYNQNRPDQPYGPPSSPWELERSKYLPTSSSQPAAQYSRVLVGKVTATCHKLQDEEDKPGLYFFVADLGTRTEGTFTLRMMMTDITSLMDPEVLLGAKAPVLAETFSEPFTVFSAKRFPGVIPTTNLTKVFASQGVKLSVRETKKGAGAGEEAEDEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L4A1</accession>
    <name>A0AAJ8L4A1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_103903</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKN1/KRE6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC69959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058952.1">
        <property type="nucleotide sequence ID" value="XM_070202851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L4A1"/>
    <dbReference type="GeneID" id="30172893"/>
    <dbReference type="KEGG" id="kpin:30172893"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02180">
        <property type="entry name" value="GH16_fungal_KRE6_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000140">
        <property type="entry name" value="Beta-glucan synthesis-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000135">
        <property type="entry name" value="Related to KRE6-glucan synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF15">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="11">
        <location>
            <begin position="204"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="17"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC69959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="625" mass="68831" checksum="E69029601247A316" modified="2024-07-24" version="1">MSRSPLLSDAASPGMSRISQSSFNSNTSMLNQNQNGYSQNTLTSRSISSSTSRFGPTASLGGLGGGINGTTTNSSNNQLNGRFTNEELSNNHDTDHEDDGMDDDLHTFTNEESKNVDYNSNLNFNSWRGWANALTLGFIAFAIVGIFALYPILDFFFFRNGNSSGINTSGYNLGGINSTGQYPSIPGLPKLIDQDTPENVKSRIGFDGEPWSLVFSDEFNKDGRTFFPGDDPFWTAVDLHYWGTKDFEWLDPSAVTTKDGNLVIAMTQEPIHDLNLKSGQIQSWNQLCFNKNAYIEVSASLPGQSNIGGFWPGIWTMGNLGRPGYGASTDGTWPYTYDSCDVGTLANQTYVNGTGPIATLTTGENGGPLSYLPGQRLSACTCPGEDHPGPDVSVGRAAPEIDIVEAQIRISVAHGEVSQSNQVAPYDDHYQFNNRSGMVEIYDKDVTMWNSYLGGYYQQAVSGLSLLPDRIYRNQVVGGRSGEFATFGVEWSAYPEAREKGYIAWVSDNKRTWTMYADAVDANPRTEIGRRIVSEEPMAMIINLHASNGFQFVDWANMIFPNYLLVDYIRVYQKDDGSGSIGCDPPDMPTKDYIERHKEVYTNPNLTTWAGAGKTFPKNRLKDQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L4E1</accession>
    <name>A0AAJ8L4E1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61</fullName>
            <ecNumber evidence="2">2.1.1.220</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">tRNA(m1A58)-methyltransferase subunit TRM61</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_102848</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.220" evidence="2"/>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058734.1">
        <property type="nucleotide sequence ID" value="XM_070202633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L4E1"/>
    <dbReference type="GeneID" id="30171569"/>
    <dbReference type="KEGG" id="kpin:30171569"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160107">
        <property type="term" value="F:tRNA (adenine(58)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000247">
        <property type="entry name" value="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049470">
        <property type="entry name" value="TRM61_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133:SF2">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE CATALYTIC SUBUNIT TRMT61A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 C-terminal" evidence="11">
        <location>
            <begin position="27"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="226"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="226"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="258"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC68912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="388" mass="43357" checksum="91866AF90569D4C1" modified="2024-07-24" version="1">MFHSRSTIEAGDLVIIYMLHSPPPHSGYIHILRPTPELWTLSLPHRTQILYLPDISYITMRLGIRVGGTVIEAGTGSGSMTHSLSRTIGPTGQVYSFEYHEPRYEKALEEFQSHGLNNVRLQHRNVCKDGFADAKGVEAVFLDLPAPWEAIPHAMKTLRPDIITKICCFSPCLEQVLKTVATLRSEGFAEISTQEVLIRTHELVVPNDPDHLGSVSSIVDQLKAHEKRKTDRRAVQMRIARDKARRQKEAESGMVSERPVEVGSKRKIDERQESSMEQSQEEEEEYARTSPTWIEPITQLDSIVLTKPTAEMKGHTSYLTFASYYPESIRSAIAAQDIGKSAIATPRLAELVNEGRVRAGSQETEYGSDGLDEVMGTMTEEEMIALAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L510</accession>
    <name>A0AAJ8L510_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutaredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_103164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SH3BGR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013759.2">
        <property type="nucleotide sequence ID" value="XM_019153598.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L510"/>
    <dbReference type="GeneID" id="30170200"/>
    <dbReference type="KEGG" id="kpin:30170200"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006993">
        <property type="entry name" value="Glut_rich_SH3-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051033">
        <property type="entry name" value="SH3BGR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12232">
        <property type="entry name" value="SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12232:SF0">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04908">
        <property type="entry name" value="SH3BGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC69227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="34394" checksum="F18FC59CF824E452" modified="2024-07-24" version="1">MAPPPVTIYVTSLTSAPKVRKHIDLLRRSLNGLEIPYEEYDLVMDEEAKKKWQRSKPPGVVVGLPGYLVGGEWVGTMEEFEDAVETQTLETFLKQDIDLSNYNTNTNTNSSLSINNKDDNKDGNDNGKKQKSIQEVELENLMREMTNEDLDKLINDLNVNSENSEKEKEQIGKIGLLNEKNKLPISDIKENDQIILNDLKKELNLDKNEDDFLKKIENNNNNNELNSSFTSSIDHDNSKNEIDKEIESNKKDNVEINKGQGTNDLEFIPESNILKELKDELKLDKNEDKDINEIKGKEKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L609</accession>
    <name>A0AAJ8L609_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcriptional activator HAP2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_104703</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NFYA/HAP2 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059089.1">
        <property type="nucleotide sequence ID" value="XM_070202988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L609"/>
    <dbReference type="GeneID" id="30170610"/>
    <dbReference type="KEGG" id="kpin:30170610"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001289">
        <property type="entry name" value="NFYA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12632">
        <property type="entry name" value="TRANSCRIPTION FACTOR NF-Y ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02045">
        <property type="entry name" value="CBFB_NFYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00616">
        <property type="entry name" value="CCAATSUBUNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00521">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51152">
        <property type="entry name" value="NFYA_HAP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="44"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC70752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="285" mass="31612" checksum="22A883B56852293B" modified="2024-07-24" version="1">MSTTLPLFSLLHNGGGSYPPSPTFSDPSFSTGYDGAFDLKNGGLGNYNFPTPPQTSNTPSTSSYSSRHLSNYPQLIPPNFSHSSFPTTPDGDDPTSSFLDLDLSQPGPSTYHQISNGHHRYDDALSHHQSTSNGGSFILDGEDYLQHDDDDDDEEGGLINEDIGVEEEDDLVKIENGESDEAQPQDEGGDVDVDNEEPLYVNAKQYHRILKRRLARARLEELNRLVRSRKPYLHESRHRHACSRPRGKGGRFLTAEEIEQMKKEELEKVENGESVEILDGVAIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L724</accession>
    <name>A0AAJ8L724_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_103984</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058965.1">
        <property type="nucleotide sequence ID" value="XM_070202864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L724"/>
    <dbReference type="GeneID" id="30172811"/>
    <dbReference type="KEGG" id="kpin:30172811"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="298"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="406"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="443"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="500"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC70040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="903" mass="100207" checksum="0977D3C1C6F48C1C" modified="2024-07-24" version="1">MSEVTPKTGDSLLTIDTPLDNISSTTISTTKSKSTESGSEFSDSSSSLNDSPVEDIGNRPESNSAFPLTADNSSSSHTSKIRSVPIRKGQQATKKGTKSSDANSKTQSESELSKSDQDDTSGSSDNLSASSDTDSDSVDVTTELDEDSKDTATKLKPSEREKRSETDSRVDLLRKDRSMEGEKLTGPRDRTIQGGSKKVVSGSNTKVYPKRPTEGREELEESKRIPRLGESEKENKEVSLLTKRRETPRTWKHDMIRLISLYLVPVLLGIPAALLLSLNIQLLTPLYNSIPLSLHTPPLYVGYTAIAALIYWYITSRIPAKDIISARICLGLVALSGDILAVYGRRIGSISGRLLGAEYGAIASRALMGIGVVGGTTIFGLLCFDHISHIPPSVDKTDRSRSLGSVLYRSAFYVLHIYTFERLWTTYLSNNLSVLNGNPEKTILFISLILTALSLFLKSSTSSTPFPTRINHLVNRSLKLKSENAKKVSNITNNILPRQAFPLLLLIRIPFLVLALRQQIFLRPPSTSLQPYITANGELRVISSEKSITGQIVVAENLKDGYRFLRCDHSILGGRWIREVEDKSKSTGKRIDMGDSIFATFNLQEIVVLAHRSDPSESLIKTLQLTTDLEVSLEGENHEEEDEIPERALIIGLGAGIAASTFSRRGMFVDIVEIDPAVYLASHHHFGLSSHPITSTNIMDGSLFISQLAEMKRDNFTDHNTIPEWDYVVQDCFTGGSVPGEMFTREFWEDLGDLVKDDGIIAMNFAGVLGSKASKAVLVTLTSVFPQCRAFGDSFEINQGPNDLINMVVICTKTYSPLLTFRKPILNDIMKSPLRSHIYSNFQINEIYLNDIINLNDFENLEYHLSKKNDKSIKELNKWQIQSSFATWRAMKNILTPEMWLAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L7C9</accession>
    <name>A0AAJ8L7C9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_104393</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010724.2">
        <property type="nucleotide sequence ID" value="XM_019155766.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L7C9"/>
    <dbReference type="GeneID" id="30172395"/>
    <dbReference type="KEGG" id="kpin:30172395"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF29">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="167"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="217"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC70442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="801" mass="88555" checksum="CF8DBC91BFED2565" modified="2024-07-24" version="1">MSRPYNPKYDSVLGPMREPSPPPSSENPFSHDASFLSQLDPSRVDVADTEAALTHLFGDVVNQAQQDDHTTSQAEDGVNKQEMQIGLTDHQLQAEQSTPTLANQEVTTTESLPLSTPEGGESDANHILIDPSLADSETGSAEPTSLPGVPVKRKATSRANMLARGGACEFCKKRKLKCSAEVPSCSNCSKVGKECVYSQKKQRSRVRVLEDRLQELEKRLDPKNTTSNTANESPIQQVNITSNNNSTTNGNTDSTYDPTDYPTLSTFEFDHHLEDPSNANPVGVDLGLEPDLMTLADAAAADTSVEYQSWQGLSPELIVGEIIKAVSGGSVPGSDGKSVGEKIVSHLIQLYIGPPSLPVLHPAVSPTTLLSRLTNRHRPIHPSLLLSLIPFLLPLSPSQILHSPSIPLLIQTHAKGLISNAITNSDPRIIDIIAACTIRAYGFYEQARYFEGWTESASATSMVYAAGLHKLGRVGEKFISQVNIEGRTERVDREKKLRVILGKGVAVSPPIDRVELGERINLFWFAYANDRGGAAGWGWPSSFNDEEITTPWPRDDYDNDEALLDNRTITDFMDTTAPSHDDGSKDTLHAAHCKAITLFYHANRLFDMPSRLATPERTSRLIRLTKRYMSTSIPVRADEGIERSPRNEIRMTLHAVMCVLHAKEEIDAPPGSEREYFDKSIESTGKALEIIQNMQMDGNVDLDGLEITSAMLFHFFGRLMTKYLHKITPTNLQEWQGETLNNEKDIEVINDLLRKKEGFSNALETLGKRMKFANISCRLLDNIAYGSDFKMGEYERPDNMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L7G8</accession>
    <name>A0AAJ8L7G8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_106044</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059330.1">
        <property type="nucleotide sequence ID" value="XM_070203229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L7G8"/>
    <dbReference type="GeneID" id="30173236"/>
    <dbReference type="KEGG" id="kpin:30173236"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024789">
        <property type="entry name" value="APC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024790">
        <property type="entry name" value="APC4_long_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260">
        <property type="entry name" value="ANAPHASE PROMOTING COMPLEX SUBUNIT 4 APC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12896">
        <property type="entry name" value="ANAPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="7">
        <location>
            <begin position="58"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4 long" evidence="8">
        <location>
            <begin position="237"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="800"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="801"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC72084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="824" mass="93410" checksum="E0665A4B9AFF1894" modified="2024-07-24" version="1">MILPDRTSFTPLSTISLPSSHILHPGSCNPSMDLVVLLSHPFNPSSNSWKGKGKEIGKTQISLWRTGGSKVWEVNVTGQVVGLAWSEDGLILSLFTWSNERTIDHLSVHTGEVIRSIPFPQNLNVGHIDDLRAGKWIDMKWVQAQNDWDRVKNGSSINIIDSLPTVTPVDPPKPPNLLPFMQKSNKPEPRPTFHSLLKSFPSLLPSNIPLPPNILSISSYPFLTGTLPLPPSQGKENAQEILELSKISDRMSGYLDIILRGLENAEIAFRESEKQTMICREDLETCAQQQAMTIPDVHSDLFRFLMTGRSGVAVNEWLGSKLTGRTLTKWDQTLDSSYKSIQNLIIESISPALERLVLLLEEMKGWSRTPRYQARIQLREDDVVKATDLVLGFAKLMEKMRRDAEHEMKAASEFMKWLKYEIVRAASQDTSSDDIPTPTHDLKLVWSFMINGFVHSSFHDHFPYLSVRPPKDFLPDEFTRYTRKPNRNLDEVLKETQTELGIIKKEIMYTPSTKANESLNSTNGSESTMSMDMSMSVVEDEDNDEDVDRDLTPTGILSEDEEDLLSSPDTVERKNLYAVQEEEEIERKIEKEPWVWINTLVRDLEKLIKDAIGLIDDGYNLPLNDGMRDKRIVQGGLWEVLVSKNDKDEQQIWLMYTSDSASSSPSATAKISTFALFDSEQSLTCLSIQFFDDDEIVLLLESENGRYLVTLRYVELLDLEQMVEMNVSDIRGIDDIVKIHQNTFQAILPIPISRSRYLGVTPQFDTSLDHTKVAIALNGRTGRRLGCVAFEDGRSLQVWDLDVDEDEEDEDEQEEQEDGEGEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L8Z2</accession>
    <name>A0AAJ8L8Z2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_106379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059405.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L8Z2"/>
    <dbReference type="GeneID" id="30175551"/>
    <dbReference type="KEGG" id="kpin:30175551"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF8">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="1">
        <location>
            <begin position="24"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC72417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="557" mass="62539" checksum="0B838DA0E04C8807" modified="2024-07-24" version="1">MGNVLSPKETEYTYEECTADLGKLGQLKGTLIDGRVKRYVNVPYALPPTGENRFKKPRPLPIDYSYSQDGLPRNAVDFGLPCPQPTYTSLPVSELAEDDGSAKEYPYDEDCLKMNIWLPSGPPPPEGYSVYAYMHGGWLQIGDPSIDPKMDPTELISTGGLNCIFISLGYRISALGFLACKELQEESLDGSVGNYGLWDQRVALEWIHDHIGALGGNPKRVVVGGRSAGAYSAHAQLVHELLQAEPTEGGLFHRIILISNAIPCLPKTVEETQDQFESLLTALDIPLTLSGPERLKALRAVPAETLTRKIMTIDQFTFRTVQDGVFFPKSQTWLSDGKLADEFKKRDMAAIIGEVQDEETLYRDGFRVTDEISLYKAVNQYYSSTVVNQMIDLYLHQKIKEPYQHPDPNPNIDSYTKVLGDIISDGQVRAPSRSLTRQLRDAGVPLDSVHRYIVAWVPNFVMKFAPKEFGITHAMDRPIHNFSIFHGPDAHEDKLMTEWIKDYANFINWKSVNFGTETWTQVKVLSPKDHGSIRIEDDTKWSYLEKVSEVIEGRSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LC58</accession>
    <name>A0AAJ8LC58_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase S9 prolyl oligopeptidase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_107425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059614.1">
        <property type="nucleotide sequence ID" value="XM_070203513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LC58"/>
    <dbReference type="GeneID" id="30174120"/>
    <dbReference type="KEGG" id="kpin:30174120"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WWC73455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="37087" checksum="4CDB1A74C5CFA0B4" modified="2024-07-24" version="1">MTSNNLPYKTFTFTFDPINKVELDVYVPLPNENLNIKRSIFPHLSLRPIDRQKTIFISANYRLLYPSTGSDILEDVETLFKYLSSDSTELSSTLKKLGYKLDSTKLGVIGISGGDYPARASFILPSIPKDIKPKAYLNLYGMAGDFLLDHWIKIKEEGNNLPRFPYDIEKVKLILSSKLNQISDSPINPTGDSSGRVDLLSHFYHQGTLLDYLLDQVGLSRQLENLSYKDRFSNIPKEKQYLLLPFNEDIDYPKSIIFVHGKVDTVVPAQASYNAQEQLKSLGIESKAFWVEGANHGLVDDSNFPNSVPGTEAIFDEAVRDILNALQPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LC75</accession>
    <name>A0AAJ8LC75_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trafficking protein particle complex II-specific subunit 65 IgD3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_107455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009139.2">
        <property type="nucleotide sequence ID" value="XM_019157499.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LC75"/>
    <dbReference type="GeneID" id="30174153"/>
    <dbReference type="KEGG" id="kpin:30174153"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055420">
        <property type="entry name" value="IgD3_Trs65"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024662">
        <property type="entry name" value="Trs65"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28159">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX II-SPECIFIC SUBUNIT 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28159:SF1">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX II-SPECIFIC SUBUNIT 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12735">
        <property type="entry name" value="IgD3_Trs65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex II-specific subunit 65 IgD3" evidence="2">
        <location>
            <begin position="667"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC73485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="825" mass="92141" checksum="5693503C43301F21" modified="2024-07-24" version="1">MPSPNLASSAQYEQLFQSSSLNLIIPEISSLPIESTDNSSESLTKWWDKVEESQTRNTAFFDEKLFYFLSMHLPDEALQSLPGTPILEINEPTSEMLRYLSRLQLTMIASFIPPLPPKQFTSASSMPTSSSSLTVPHTPVNQITSTVDGSNPPVTPNPFPTMHSGEEQYANVEGVIVWEGGVEEITGQWEEGKNKSSAGSGRKVIKAKDGWEIIWTGEVPIAYVRTQIQNPLLALTASITLRDQSHTKTHRRNAHSVDTSSIRSGTTTIRTDGTEYEAYEDGDDGNEYAELEEIDLLGGLAGGIDSMPSTRLAPSLREDLAVPLSSKTNSPLPISALTPATAPTIITPSTTSSGPSRERGIPLTSIQPIISTTLRKSYRRVLSLAPGLRVRMRTLFLPQLLTGDKAEEEGERCITLCVEIENSPELNLNDGFEVSEVKVDVGGKGGKASTELVKNQIQSIDFPLRLRSIEQYNLLYKVSIASSQIDQSNKEGIEEIVNKSLGRNDEIRPVSIIIIGKPFSKNKEEYKYQTKEFHSRWNCSLDLTSFYNSSNSSSSLNNIPSTITTTDKNRNLKNGSLQPTINAIAGDKRYSLAYLLSIEKENQNQNKRPLMPSQMIGQNRINSLNNNNNNHNYKSNLIKKEENGLMISIKLLPSSSFDYNSESEMKKLIKQYEIFSLEIFIYNKSNEIRRFKLIIPPPFKNSNSNSNLVQNKEKGKGNIKIESELKEILNKNKIKQEELKIGFIKEEEDLIIKQNLLNYLLTSTSILPLENDIRCGPLLPFTSLSTRIRFLALKKGIHKIESLRIRSNNDEFDFMISPVLDIVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MKJ5</accession>
    <name>A0AAJ8MKJ5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase</fullName>
            <ecNumber evidence="5">2.7.8.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">GlcNAc-1-P transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">N-acetylglucosamine-1-phosphate transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">I206_100763</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis, transfering GlcNAc-1-P from cytosolic UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol embedded in the cytoplasmic leaflet of the endoplasmic reticulum membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UMP</text>
            <dbReference type="Rhea" id="RHEA:13289"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
            <dbReference type="EC" id="2.7.8.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:13290"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 4 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.15" evidence="5"/>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058372.1">
        <property type="nucleotide sequence ID" value="XM_070202271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MKJ5"/>
    <dbReference type="GeneID" id="30168933"/>
    <dbReference type="KEGG" id="kpin:30168933"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003975">
        <property type="term" value="F:UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06855">
        <property type="entry name" value="GT_GPT_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033895">
        <property type="entry name" value="GPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571:SF0">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="261"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="WWC66856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="503" mass="56601" checksum="AB06F45BD242BA41" modified="2024-07-24" version="1">MTQKYGHRPPILLTLTILPISLILILNPLIPLIIPKWIFKFSTSLSSLIKEDEYKFPALQANLGFSLLAFIISIWLIPKVSESFILKGLKGRDLLKSGDKLNGPWVPESLGLPCASLYLALMMLFIPFPFSHLFKSHSFSSPETFPQRELTLYLSSLLSLLTATLLGFIDDLFDIRWRHKLPIPIVSAVPTLLVYYSVGGVTSIVLPKSIVGWLSSIGFGGFMKGNIVDLGPIYYLYLIMLPTFTTNSINILAGINGVEVLQALIIAISISINDLIFLPIWSINLLNLFGFKNPENGRILNWAIGEVVNRHLMSLYFMIPLIGICLGFLWHNWYPAKAFPGDTFCYFTGMAFSAVAIQGHFSKTLILFFLPQIFNFILSCPQLFGLVKCPRHRLPSYDEKTNLLNPSKVLFDSSPPKKTIIVLKLLSILKLVKLEYDVDDNNNKEYIKSSTNLTILNFLLIHFGPLKEDKLCILMGLIQVLGSLIAFIIRYGVGSWFYGGERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MN78</accession>
    <name>A0AAJ8MN78_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Septation protein imp2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_103634</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013298.2">
        <property type="nucleotide sequence ID" value="XM_019153137.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MN78"/>
    <dbReference type="GeneID" id="30169733"/>
    <dbReference type="KEGG" id="kpin:30169733"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120104">
        <property type="term" value="C:mitotic actomyosin contractile ring, proximal layer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07651">
        <property type="entry name" value="F-BAR_PombeCdc15_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000312">
        <property type="entry name" value="Related to Cell division control protein 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF7">
        <property type="entry name" value="NOSTRIN, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="F-BAR" evidence="10">
        <location>
            <begin position="47"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="1015"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="342"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="352"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="445"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="512"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="536"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="663"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="718"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="752"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="827"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="867"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="906"/>
            <end position="956"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC69691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1074" mass="116894" checksum="1D2B9C71E0837A1D" modified="2024-07-24" version="1">MNQPPEPKRSQSTTSLSRLYHGSGGVGGGKQNEMNNNEEEELIDPKLDFCNSFWGQGDRGFEVIMARLRGAGRTVDELKGFWKERAAIEEDYAKRLNKLSKHAIGKDEIGDLSDALQHLLTETASQGAYHASLGNEIRQTVENPTVELAARLSNLKKGLQASIEKGYRNKGLQEQHVHKARDRYEQDCLKLNSYTAQSSLTQGKELEKLQTKLDRVRQTIGANEQDFRQFVKVLEQTQARWESEWKGFCDHVQDLEEDRLALTKDLIWVYANAVSQVCVEDDSSCERIREKLEQFEPHNDMLNFVKGWGTGDMIPDPPRFINYNAGESYPTQPAYHVSHFQRISSRPPMPPSLAQQAASQSEPEAQQPEEPEQEIPQANGHDKDMNGISDNFQRTTLKDEPPSNQPAPAPPSQKKNPFGGIALPGLANSTSPPPPEDTSGKFSSMPPPPTPPTMTMPEPRIPSRQGNNSPAPRMVNLQEDPMAKALADLRREPPPPGSVRRNASHRRPESVVSASGSTRNQYGGIKSPSSPGPNRMSYQQGAAPTHSQSRGSVDMTLSPPQPGHTAAALAKSMEEFRQQSSRGPGHEAKRQSVNYSNFGDDIVGAHPTSRPSSPSVAPRGPSPAMMQPPTQPATHIADEVLSQYHQAFPGERQERTRSRAGSVISSHSRAGSYVEQQQRPPPSPGREAFAGIGAGGGRSPSPQPAVFRSPSPSPMMSQGSLGPQNLGISLDAKGGVAQDTMAEQYRRQFERQQAQQGPPPQQMSSYPGQRNSQYGQPPQPYGQDQRNSTYGGQPPKSPSASAQTHDRSSIYGGVPKSPVAGPGQGQPPISGNRPTSGFNQAQSFGGSASSHQGYNQQPQQAPPPQPAYNSYPAQSQQPQYPGQPQGYGGSQQQQPNGPPQPAYGQHPSSQYPPQNQTNGYGAPQPQQYNGYPTSPSVNQNQYGRSASPAPQNQFARSASPAPVPQQQQYGYNREPSPQPQYGGSVGRAGQSPSPQPNQPPNNAAPTGQWSTTGLPVLFYVKALYDYGAQSSAEFDFQAGDIIAVTSTPEDGWWSGELLDEARRIPGRTDFPSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MNY9</accession>
    <name>A0AAJ8MNY9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_101996</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC68077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058589.1">
        <property type="nucleotide sequence ID" value="XM_070202488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MNY9"/>
    <dbReference type="GeneID" id="30175281"/>
    <dbReference type="KEGG" id="kpin:30175281"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12276">
        <property type="entry name" value="RRM2_MEI2_EAR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23189">
        <property type="entry name" value="RNA RECOGNITION MOTIF-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="114"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="282"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="68"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="333"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="408"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="454"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="493"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="510"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="530"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="594"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC68077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="625" mass="66641" checksum="0981D9C9F85EA9F4" modified="2024-07-24" version="1">MSHIPPPPPFLPAPPTFNAFSDHGGSSASGGYDPNQSAPSNDGPPRDMYADRSNNDRRGRGGGGGRGRGSDRGGRGGRRDGPGRDRERSPTRGGQSRRENRSVEDRIQAERVCRTLFVRNVSYEADSAALQNSFSTYGEVKTWYDRIKERGIIFVTYFDLRAAQKARDAMHGLKAGDRSIDVHYSLPRDKDLIGDCDREKNQGSILIFVHPPRVVSEYELGRTCEQFGDVKSIKPGREPAEKIVEYYDSRGSALFFDRMSNQPFQGGTLELKFIWDEKEDALPPPPLLERAKTQGHRSGEGPGYGEVRGSRNSGPPPPPPFNGPGGYGGSGSRDPRARSPVRGDRRGSYNSNPPSQGRYGSVPPSIPPGEDRLEQARKVQQLLANLGGPPTHSAAAPPPNSAHALPPRNMPPPHNLNGPPPTLSGPPSSMYPPRDTGYNPGPAPGPPSNYRSSVPPPAGNFPPYPPASNTGPPPPAPPTQGYNPASNYPPPGNSYNTPTPNSYGGAPSQGGYNPPQSSQGGYIPPQSYNAPPPNQSPYNPSTPAPIQPPPQSYPLYPPAAGGGPPPPSSSYMPPPQGYGQSANSGGYGYPPQPSQGNTNQGNNNNNSRTGQAKDVGSLLAMLSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MQX6</accession>
    <name>A0AAJ8MQX6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nuclear cap-binding protein subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">20 kDa nuclear cap-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_104079</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRM NCBP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058984.1">
        <property type="nucleotide sequence ID" value="XM_070202883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MQX6"/>
    <dbReference type="GeneID" id="30172715"/>
    <dbReference type="KEGG" id="kpin:30172715"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027157">
        <property type="entry name" value="NCBP2"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847">
        <property type="entry name" value="20 KD NUCLEAR CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847:SF0">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="1" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="73"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="134"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU364036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC70132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="170" mass="19754" checksum="EEC0CDB9AE16AFCC" modified="2024-07-24" version="1">MAQVVTPLDQPSSYRDNRSEIDRETERRLLAQSSTLYVGNLSFYTTEAQMYELFSTCSRPEEGGGVKRIIMGLDRNQKQFGRGKSGGQVRDEFRQEYDSGREKRRQEQERLRSQIQFDTYAAVGGLGMAGADVPRGEESERDRQKRDRSEDEDIERRDDEKRLRGEKDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MR87</accession>
    <name>A0AAJ8MR87_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">I206_104669</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25 26">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012712.2">
        <property type="nucleotide sequence ID" value="XM_019153972.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MR87"/>
    <dbReference type="GeneID" id="30170576"/>
    <dbReference type="KEGG" id="kpin:30170576"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.150:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1070.20:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007175">
        <property type="entry name" value="PRK09606.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="19">
        <location>
            <begin position="73"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="18">
        <location>
            <begin position="296"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="20">
        <location>
            <begin position="513"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="21">
        <location>
            <begin position="610"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="22">
        <location>
            <begin position="700"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="16">
        <location>
            <begin position="782"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="1159"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="WWC70718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1253" mass="141863" checksum="4F6DCDBB27CB7EFC" modified="2024-07-24" version="1">MSQPQSQEPTLVDDGFSYDPNYDYSQTASGGITQDVKDEVKYDINEDLEEEEEEPISQEDYWTVISAFFDEKGLVRQQLESFNEFIENTMQEIVDDHSKLTMDQFTQYTGVSGDETKRYEISFGQIYLARVNHTEMDGRTNMLFPQEARLRNLTYSAPLYVDIKKRLLTASGVDDPIEADWQPAVGEDGLPEGLEEDKASIGKVPVMVRSNFCLLHNLPDDQCHDIGECHYDQGGYFIISGSEKVLIAQERMATNHVFVFLKAAPSRWTYFAEINSQKEKGGKVAAHTEVRLYQKIQGQNGGVIRVSLPYTKVDIPLVIVFRALGIVPDRDVLNHICFGPNDEALLEYLQPSIEESFAIQDREAALDFIGRRGQHEKAPRAQRQRAAFDILHKEFLPHVSTAEGFESKKAYFLGYMVHRLISAAMGRKELDDRDHFGNKRLDLAGPLMAEMFGHMFSKLREDMYRYLKKCVETNKPFQLNTAIRPNSITDGLKYALATGNWGKRGNTRAGVSQVLNRYTFASTLSHLRRTNTPIGRDSKAAKPRQLHNTHWGMVCPAETPEGAACGLVKNLALMSYISVGSYSAPVMEFLEEWGLEELNEYQHAPQATKIFVNGVWMGIHRDAPTLHSNLLQMRRGGQLKHEVSIVRDIRERELRLYTDAGRCCRPLFIVDHPTQTLRLRREHINRLEDAGEQGALASAWEQLLSEGIIEYVDAAEEETILIAMTSEDLENARRKNSREELVKDRSAHDLESFDPTARIKSTVFSKQYTHMEIHPSMILGVCASIVPFPDHNQSPRNTYQSAMGKQAMGVFLTNYQLRMDTMANILYYPQKPLATTRSMEYLKFSELPAGQNAIVAIMCYSGYNQEDSVIMNQSSIDRGLFRSLYYRSYTDTEKMKGMTKAETIEKPDRNETLRMKHGSSDRYAKLDVDGLVSPATNINGDDILIGKTAPLPEDTEELGQRTQMHQKRDISTPLKSTEQGVVDQVMLTTNGEGHKFVKIRVRSTRVPQIGDKFASRHGQKGTIGITYRQEDMPFSAEGLVPDIIINPHAIPSRMTIGHLVEALLSKVSTLTGSEGDATPFTELTVEAVSKVLRSKGYHSRGFEVLYHGHTGRKMQAQVYFGPTYYQRLKHMVDDKIHARARGPLQILTRQPVEGRSRDGGLRFGEMERDCMISHGIAGFLKERMYDSSDAFRIHVCDICGLMAVANLKKQEFYCSVCRNSTQISQVYIPYAAKLLFQELQAMNIACRMYGEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MSD3</accession>
    <name>A0AAJ8MSD3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">mRNA m(6)A methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.348</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_105605</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an adenosine in mRNA + S-adenosyl-L-methionine = an N(6)-methyladenosine in mRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:55584"/>
            <dbReference type="Rhea" id="RHEA-COMP:12414"/>
            <dbReference type="Rhea" id="RHEA-COMP:12417"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74449"/>
            <dbReference type="EC" id="2.1.1.348"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MT-A70-like family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.348" evidence="1"/>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011395.2">
        <property type="nucleotide sequence ID" value="XM_019155241.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MSD3"/>
    <dbReference type="GeneID" id="30171864"/>
    <dbReference type="KEGG" id="kpin:30171864"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036396">
        <property type="term" value="C:RNA N6-methyladenosine methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001734">
        <property type="term" value="F:mRNA m(6)A methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829:SF7">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC71647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="397" mass="45440" checksum="75DDBF23DAFB8F05" modified="2024-07-24" version="1">MEVSTIAEFSTDQASINEAGPSRKRHHYDTARELNALIDKESARTKLRRIAAQNKDPRNSKPFNPVCSQTTLESCKAIRQICDKAHYEPIIRPWTDISLGYCSYLNLCYGDPMFAKNPSLGEGNGPRGGVKECRYMHFQVVPSAKTHNSKKPDIPHLSSTTIKRLLGDEEKKIGERYNPPPVAQWINCDIRSFDYSLLGQFQVIVADPPWDIHMSLPYGTMTDDEMRSLPLRSLQPDWGILCLWVTGRAMELGRELFSVWGYRRVDELVWVKTNQLQRLIRTGRTGHWLNHTCEHLLIALKLPADHPKNAPIPWDTHPSLRQLRKEVDTDVVVAEVRETSRKPDEVYGVIERLAPHGRKLEMFGRKHNTRPGWLTLGNQLGDSQIAEEDLHNRLSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MT13</accession>
    <name>A0AAJ8MT13_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_107338</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Vacuole membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ATG22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059601.1">
        <property type="nucleotide sequence ID" value="XM_070203500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MT13"/>
    <dbReference type="GeneID" id="30174033"/>
    <dbReference type="KEGG" id="kpin:30174033"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF5">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC73371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="434" mass="48381" checksum="91FD47585A042B79" modified="2024-07-24" version="1">MNAADEDKNQAPPAQDGGMQLTDEATLFASPLPIVGERKTTTRKEVWSWYLYYVGNSGLGPFNFAISAWQNLLYQAGWDPAFPRGTVACGDGVGSFADYGVWRPHITTAFTVLAWAVSFAWLGVETPSKWEAGTALYILGLIGYQGALTFWTAAFPGLARDLPEIKESEQQLATGETDQKSHDRKDMLARNRLANVSFLVCSVGELVVLAILAGILEGVINDDPNSNTRALSIVCAYSAGVWILCAIPWLLFEQYRPGNQLPPHTSYFTVGLKQVYHAFRLCLRLKQTFIYLAAYFFLGDCLNTVVIATLQNEVVSYNTKMLNYLLIDGIAAQAIGIGIFWLIQKRYTIPTKTMLMFNAFWILVFVCPWYAISQAMISEVVPRGKESRKECRKYLEDEAIRVYGMNSAEVLVVGNHNEMDGLRPVTLGKEKKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MTP9</accession>
    <name>A0AAJ8MTP9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">OPT family small oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_107022</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC73057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059542.1">
        <property type="nucleotide sequence ID" value="XM_070203441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MTP9"/>
    <dbReference type="GeneID" id="30173804"/>
    <dbReference type="KEGG" id="kpin:30173804"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="268"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="495"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="579"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="650"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="694"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="725"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC73057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="774" mass="84981" checksum="A312D2814380AA96" modified="2024-07-24" version="1">MAVTPREAEEYELPSLAESSSKTYEDGDEITREDAKLLEGSDKLQDGDSRLEDDPTAYGRAAQDDEIIGKGSNVEALIARSVPSTDDPSLPTLTLRVILLGSSFCILGASSSMVFYFKSNAPQFSQYFVILATYPLGHVLANEKLISRGKKLFGWELNPGRFSIKEAILVSVLSSSGATAAYAADILTIMDLYFDTPVGTIPSILMLLTTQCIGFGLAGTLQSLLVNPPAMYWPSTLVTVQLFTTLYSTTSSNLSHAAQVLTTKRLRIFMIIFLFTMIYQFLPFLLFPTLTSVSILCLINNESWWMRTLGSGYTGLGVADWSFDWSSIGSSGPLYTPYWALGNYFGGLAGMMWIVMPLLLLTNFWSARSFPSPVSAGLFNSSFEKFDVTSILKPDLSLDEEAYEKAKPLLLTPYFALSYALNFAALSSVLVHVWLWHRDEIKEAISKRGTDLNDVHNKLMRSYRSVPSSWYIGLLGVNFGAAVILVKITPLQMPIWALILAMAIATIFLVPVGIITAVSNTQIGLNVLTEFVAGVLMPGKPIGNVTFKCYGYMAMSQALALTADLKLGWYTSIPPREMFACQIIGTVLGALTNYVTLESVLQSKRGYLDGSVVDPTGQWTGRSPAIFYSASIIWGAVAPARFFSGGYESLYLGFLVGALVPIACWWGHKRWPGYKLNKVVFPIICSGASIVPQYPTNIILTSAILTIISNSYLSKKFSKFHNNYIYVVSSALDAGTSMTAMIIYLLFGGVIWNWNGPNWWGNNKLDSEHCIPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HSR9</accession>
    <name>A0A1B9HSR9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Translation initiation factor 2D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_07796</name>
        <name evidence="4" type="ORF">I206_103843</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700118">
        <property type="protein sequence ID" value="OCF46315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC69900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007534.1">
        <property type="nucleotide sequence ID" value="XM_019159482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HSR9"/>
    <dbReference type="STRING" id="1296096.A0A1B9HSR9"/>
    <dbReference type="GeneID" id="30176165"/>
    <dbReference type="KEGG" id="kpin:30176165"/>
    <dbReference type="OrthoDB" id="199771at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11608">
        <property type="entry name" value="eIF2D_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000008">
        <property type="entry name" value="eukaryotic translation initiation factor 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039757">
        <property type="entry name" value="EIF2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039759">
        <property type="entry name" value="eIF2D_SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058886">
        <property type="entry name" value="SWIB_eIF2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057429">
        <property type="entry name" value="WH_eIF2D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26291">
        <property type="entry name" value="SWIB_eIF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25304">
        <property type="entry name" value="WHD_eIF2D"/>
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                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
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                <person name="Young S.K."/>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="Zeng Q."/>
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                <person name="Gujja S."/>
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                <person name="David-Palma M."/>
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                <person name="Bowers K."/>
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                <person name="Mohammad A.W."/>
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                <person name="Yurkov A.M."/>
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                <person name="Cuomo C.A."/>
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    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
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                <person name="Dromer F."/>
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                <person name="Zeng Q."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
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                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
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                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">CBS 10737</strain>
        </source>
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    </evidence>
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    </evidence>
    <sequence length="380" mass="42682" checksum="D5D63757DA252DFE" modified="2016-11-02" version="1">MFPSLSMRNFGKHPFSDMASSGSSPEKISTEAQGGNESRNSDLSKDFAKKMREAIETTIKDEPNKRKLSDFRNLLNDPNYLRDTARTVVDVSSLADTARSTALRARACLNTLDDILAYDGELGKILYDTLTIPQTDFGAAVLNTISGGDEKAFNVMIDRAMKVKSTNVPSGLNDMIRMTDLWKPFEQGYEEPNVFDSERSMLPQMIAQLHQTISNIKLRGDTQTSSEEKQDAEENPLIGQWQSFARDRLKTPLTGEQRELYYSLANDTEMTTWRVLLFRTIDTGADPVFCDELESLWTTLEEMGVARTKRPTVVERLEEALRSNDDTAMEAISTSALKTAGDSLKHLYPSDLRATASKLQLLADQLEEVREKAKNVKLRL</sequence>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Abouelleil A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
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                <person name="Birren B."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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                <person name="Heitman J."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="Gargeya S."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
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                <person name="Zeng Q."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
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                <person name="Cuomo C.A."/>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10 11">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KV700117">
        <property type="protein sequence ID" value="OCF47015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC68195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008234.1">
        <property type="nucleotide sequence ID" value="XM_019158488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HUR5"/>
    <dbReference type="STRING" id="1296096.A0A1B9HUR5"/>
    <dbReference type="GeneID" id="30175158"/>
    <dbReference type="KEGG" id="kpin:30175158"/>
    <dbReference type="OrthoDB" id="10264021at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18177">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6F_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18178">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6F_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000002">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="130"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="50"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="133"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCF47015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WWC68195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="199" mass="20560" checksum="8E9FD6B577560F0E" modified="2016-11-02" version="1">MGYFAPGLLYSSTSIATAVGLYLLFTGQGESFNVGKFLAESSPYAWALTGIGLCIGLSVTGAAWGIFVTGASILGGGIRAPRISTKNLISIIFCEVVAIYGVIIAIIYSSRVNGDVENLYTANNYYTGFALFWGGLTVGICNLLCGISVGITGSTAALADAADPQLFVKILIVEIFGSVLGLFGLIVGLLVSGKAEDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HV83</accession>
    <name>A0A1B9HV83_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Stress-activated map kinase-interacting protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_06963</name>
        <name evidence="6" type="ORF">I206_101946</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700117">
        <property type="protein sequence ID" value="OCF47185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC68027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008404.1">
        <property type="nucleotide sequence ID" value="XM_019158658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HV83"/>
    <dbReference type="STRING" id="1296096.A0A1B9HV83"/>
    <dbReference type="GeneID" id="30175332"/>
    <dbReference type="KEGG" id="kpin:30175332"/>
    <dbReference type="OrthoDB" id="241990at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031567">
        <property type="entry name" value="CRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008828">
        <property type="entry name" value="Sin1/Avo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031313">
        <property type="entry name" value="Sin1_PH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13335">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT MAPKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13335:SF1">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT MAPKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16978">
        <property type="entry name" value="CRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16979">
        <property type="entry name" value="SIN1_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRIM" evidence="3">
        <location>
            <begin position="377"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="SIN1-type PH" evidence="4">
        <location>
            <begin position="711"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="500"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="520"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="534"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF47185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC68027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="827" mass="89443" checksum="D45FB0651CC6C0E2" modified="2016-11-02" version="1">MAMISDVDFMLQAIRLSSLRITDDPLTPRIISLDPSFALNPYITASGLSDIDRWPEIKRALDSPPLEPSYLSSQHGVPKRGLRDRTGSGGGLNYTQTIMGGKSGGAGMRVSGRNTQPAEGRRSGQANTSKNYRANSTSLITDNPLSPGQERTPTTTITKTVDKTPIMDNGFFSPSGRPRADSAPVPNLLGVPSGGVTSTSILNGSNMLNSGRGLGMTANPGLLEQALSTSEASNDDLANRINATPGVIGMEAEESSLGQGEGGASQLAVTGITTGGVDSMVGVLVDEGSDVDEDEAAEAENQRTHDHGNHTDSRRVSVDTMEGEQLDFTPQLLPSASTSPPQRTSALSALLNKHVPHLISKPSELSVSSVDEPAFMPNPFTSLYARVAAPPSAPSLSLEMYFPHSDKPTDPIVAKVRKDATVEEVTGFGLYKYWEDGRLPFLSDQEDEVRWSAVGWGLRIVEDDGEVDEDFPPLDRESQISKFSYGQFAIVEATEDQIRQNAAKAPTIQRRPSRILAAPTPRPSRPPTQPPTRGNTLTVPSNMQTASTSSSFSSNEQTPLGSIAGPGLSTTATAMKGSVGLSSTSSEIVRLKIRVTASADVHFTTTINVPSDMYIADLTEVLCKKKRLQMPATDWVLCLADLTLAIPLDRTVASLEGRTDLALVKRQWATEHGLRINDRRGGDPSASIFKRQSEPAPMQRYGPGLADFTQTYKKYTVQRKIAIGRHERVLAIDGDYIHIMPSESRAFFDSMKTTSFHITLVASCKLTGRAGGFKINVWREGAQKRYEFEAENQRQATDIVSTIRQLMKSYSSDRNSILPPPRPASRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HVN5</accession>
    <name>A0A1B9HVN5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Endoplasmic reticulum protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_07097</name>
        <name evidence="5" type="ORF">I206_101813</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700117">
        <property type="protein sequence ID" value="OCF47318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008537.1">
        <property type="nucleotide sequence ID" value="XM_019158791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HVN5"/>
    <dbReference type="STRING" id="1296096.A0A1B9HVN5"/>
    <dbReference type="GeneID" id="30175466"/>
    <dbReference type="KEGG" id="kpin:30175466"/>
    <dbReference type="OrthoDB" id="2140105at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022703">
        <property type="entry name" value="DUF3533"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053001">
        <property type="entry name" value="MNNG_permease-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814:SF1">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12051">
        <property type="entry name" value="DUF3533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="451"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="508"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3533" evidence="3">
        <location>
            <begin position="154"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF47318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC67895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="552" mass="61832" checksum="9CA3B7F8D45877D0" modified="2016-11-02" version="1">MTTNNSPQPPSPSTHTVSQTPTMTEPIPTLKTNLGPSSPEDQPFKYGQGNDNSNNNEKLSRNHSRGTNINSDNNKNNNGFSPLRVYESRDANNKKMPESQTTNNLTPAKSIVASIIKPEQGGKEKKMEKFKYSFFSPEMAMFRKLALKLLIGTVVITVLVMWLTLPFYWGSLWKSNKYTDKLTVRIIDRDGGEIGQAVSSALLQQKNLRYFITSPSEFPDISAVENDIVQEGAWASIVINSGATETLNQARLIGNSSYNPSEAIQVFYAQARMETAVNSYLIPYIQQALTAILFQFNGRSVAEFLQANANNATALTTLAAAPASISTPVWYSLVNLRPYDQPVATAITLVGLIYMLIFSFIITMSNNAVREIIAPFLTTKHYLIYRICAPISLYSVISFFFAMINLPFKVHFGAHYTYGGGFFLWWFTVFLGMASVGLSTEFMITILGPKFISFFLLPLIIANVSVVSFPHELQPWIYRYGVAMPFYNASRVVRTIIFNTKNDIAKNLGILLAWIVVNIITISVATWLFRRKSVNEHNKEMGENELDKVEQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HVP1</accession>
    <name>A0A1B9HVP1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Prolyl endopeptidase</fullName>
            <ecNumber evidence="7">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_06227</name>
        <name evidence="11" type="ORF">I206_101800</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of Pro-|-Xaa &gt;&gt; Ala-|-Xaa in oligopeptides.</text>
            <dbReference type="EC" id="3.4.21.26"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase S9A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="7"/>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008550.1">
        <property type="nucleotide sequence ID" value="XM_019157937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HVP1"/>
    <dbReference type="STRING" id="1296096.A0A1B9HVP1"/>
    <dbReference type="GeneID" id="30174596"/>
    <dbReference type="KEGG" id="kpin:30174596"/>
    <dbReference type="OrthoDB" id="248387at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070012">
        <property type="term" value="F:oligopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.120:FF:000007">
        <property type="entry name" value="Prolyl endopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.120">
        <property type="entry name" value="Prolyl oligopeptidase, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002471">
        <property type="entry name" value="Pept_S9_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051167">
        <property type="entry name" value="Prolyl_oligopep/macrocyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42881">
        <property type="entry name" value="PROLYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42881:SF2">
        <property type="entry name" value="PROLYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50993">
        <property type="entry name" value="Peptidase/esterase 'gauge' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00708">
        <property type="entry name" value="PRO_ENDOPEP_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S9A N-terminal" evidence="9">
        <location>
            <begin position="53"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="8">
        <location>
            <begin position="607"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF47331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC67883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="824" mass="92179" checksum="632107BDD98F69F4" modified="2016-11-02" version="1">MTLHSVLAGSFLSKTSNEISHNKTTSSFVVPKGSWGPQAVQVSASKCPEVAYPEPPKDGGVTEDIFGIKVEDPWRSLEEQEAKSTIKFVKDQNELSIPKLSNHPLRKELEKAIEGIYNHERMDTPQKQSDGNYYWNFNKGNWPRDILVRSKNLEKHFGKEPAWSNNDDGPEIFFDLNKEENTSIYAHSFSPSGKLWCAVLQESGSDWQSIRVFDTTTKQPIEKDVGGSKFTFGVTWIGEEGYIYKRIMDYNTEDGSLFREDGSYGMFYHRIGQPQSTDIAVLPFTGEFAEAFAGKPYIVSSDHSASPRKRSFLTFDLYRNTSPETELFIVELPEGPNKADGKVIEELIKKNRKWISKGFTGETKYIGSLTSEKHFFYSTADGNPAGRIVTFDTQDWNETSVDSILPIKEFTPVNSEGHQLQFGQLVGSKILVLVYLKHACASVVFINGLTGKQLGSADSVDTKGNIDLDNNIEIPIPEEEFEISNSERVIIPEHGSIQPISSRYDSDDFYFSVDTWVAPSYVLKGTIVPKGDNFEVDISSLGTKSNKDESEENLVCSQIFYDSHDGMKIPLFICHPHDLDLTKPQPTLLHAYGGYCAPMLPHYDAFFASYMRNLRGIVAIACIRGGGEYGKRWHDAAIGTKRYVAWEDFSYAARYLQTQGLTTPALTSIYGSSNGGLLVTAVTNRNPELFNTVFADVAVTDLLRFHKFTLGRMWTGEFGSPENPKDFPTLFATSPLHNVQSEKNIKYPSILITTADHDTRVVPGHSLKYLAEVQNKQPNSITEGKLILGRIYKDAGHESSAKSLKQIVDEVADKLVFSLLTVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HW39</accession>
    <name>A0A1B9HW39_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein mago nashi</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_06384</name>
        <name evidence="5" type="ORF">I206_101646</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mago nashi family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008702.1">
        <property type="nucleotide sequence ID" value="XM_019158089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HW39"/>
    <dbReference type="STRING" id="1296096.A0A1B9HW39"/>
    <dbReference type="GeneID" id="30174753"/>
    <dbReference type="KEGG" id="kpin:30174753"/>
    <dbReference type="OrthoDB" id="6495301at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11295">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1560.10:FF:000001">
        <property type="entry name" value="Protein mago nashi homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1560.10">
        <property type="entry name" value="Mago nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004023">
        <property type="entry name" value="Mago_nashi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036605">
        <property type="entry name" value="Mago_nashi_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638:SF0">
        <property type="entry name" value="MAGO HOMOLOG, EXON JUNCTION COMPLEX SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638">
        <property type="entry name" value="PROTEIN MAGO NASHI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02792">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89817">
        <property type="entry name" value="Mago nashi protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF47483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC67734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="153" mass="17948" checksum="4CDE6F5D70FF2470" modified="2016-11-02" version="1">MATAELERDPFYLRYYTGHQGMHGHEFLEFEYSHGRIRYANNSNYRNDSLIRKEMFVGPAVVDELKRIVRESEITKEDDVAWPKKNVVGKQELEVRIDKEHISFETAKIGSLADVNESSDAEGLRVFYYLVQDLKCFIFSLITLHFKIKPIQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HWW2</accession>
    <name>A0A1B9HWW2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_06667</name>
        <name evidence="10" type="ORF">I206_101364</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008979.1">
        <property type="nucleotide sequence ID" value="XM_019158366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HWW2"/>
    <dbReference type="GeneID" id="30175036"/>
    <dbReference type="KEGG" id="kpin:30175036"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000529">
        <property type="entry name" value="Membrane transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF5">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="503"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="544"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="596"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="663"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="98"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCF47760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC67456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="695" mass="75339" checksum="44171374432D9A76" modified="2016-11-02" version="1">MLPPPPTSRQSSYIYSHGQPSTSLNSNSPYKSKGHGRIPSFRTAAENVLGLAHDDGGGGGEGDSNEEEDEDNNSDKGVERGLEETLEKIGFGPYHWRLLALCGFGWMSDNSALQCIAVILPRVQVHFNLTSKVVGLLSASTMAGMMIGAVAWGVVSDLLGRALPFNATLFLTAIFGIAASFSPNFTILCIWMFLLGSAVGGSMPTDGTLFLENLPHSKQYLLTLLSVFFSLGAVFSSVISLVFLPGHSCKTFEECDVPAGDNEGWRRVMLVLGLFNLLCAFARWFLFRLQESPRYLVSNGREAEAVVALQAIASFNSNSINIQRKDVQVIEEMSMGNEMEETDQKNSELPSPNPQEELPIWNSRIDVPSSSGSGSDVEGRYGGVGIGVNKNKKVPLRTGSAFYNTLTPGFNDGSEIDENRFESSFANASNSTKYGEQQDSTERQVLFDSANNPDDNENSERPREKILDHTIEREGWHAVPLVWWESWIKQMSKLFVPKWRKTVILMWIIWGAISFGYTMFNVWLPSVLESKASGEGDEAIKEALGDFVLYSLAGCPGSIIGAWMIQTHLGRRKSLAICTLATGLSTFAFIKVEAKWAVVVSSMVISAAATAMYAVLYGMTPETFGTSIRGTACGTSAALSRFTGVMAPVSAGFLLSITPSLPVFISAAIFVLTAGCALALPFERVGGRSGGGLMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HY43</accession>
    <name>A0A1B9HY43_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">I206_06039</name>
        <name evidence="18" type="ORF">I206_107705</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="KI894014">
        <property type="protein sequence ID" value="OCF48171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009390.1">
        <property type="nucleotide sequence ID" value="XM_019157750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HY43"/>
    <dbReference type="STRING" id="1296096.A0A1B9HY43"/>
    <dbReference type="GeneID" id="30174408"/>
    <dbReference type="KEGG" id="kpin:30174408"/>
    <dbReference type="OrthoDB" id="10259843at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17947">
        <property type="entry name" value="DEADc_DDX27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="207"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="238"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="427"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="61"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="625"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="207"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="99"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="144"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="625"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="646"/>
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        </location>
    </feature>
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        <location>
            <begin position="677"/>
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        <location>
            <begin position="711"/>
            <end position="721"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="760"/>
            <end position="775"/>
        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="788"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022840"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OCF48171.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="WWC73733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="798" mass="88393" checksum="F0B24C3AB1844DF4" modified="2016-11-02" version="1">MANDFITTIDSDDEAPQFGESSIQKGKTPTKNDDLDPDFEFDFAGGRETGLDLWGGDEVTGFKNGAEPINVDDIIARRRGKPLESYNDRKRKRKAAKEEELEEGSEEDAEEKEDEDENMDEEQSEVELSGSEEDEEMSAKDSDLELGTDDEQAEDEEAESEDDDEEEYEEEAGSSDEEDEETAAELARKEAFFSKDPSLTDDPTLPSTFAAMNLSRPLLRALTSLQLNTPTPIQARAIPLALQGRDILGSAVTGSGKTAAFMIPLLERLCYRDRGKGGQACRVLILCPTRELAVQCEAVGKALTEKGGLDVRFALLVGGLSLNAQAHTLRTLPDVLIATPGRLIDHLTNTPSFTLSALDVLVIDEADRMLEAGFTDELEEIIKACPRSRQTMLFSATMTDSVDELVKLSLDKPIRVFVDPKRNTAKGLIQEFVRIRSDETRSPSLLALCKRTVREKCIIFFRSKALAHQMRIVFGLNGLKAAELHGNLTQEQRLQALNDFKAGSVDYLLATDLASRGLDIKGVETVINYDMPGQLSQYTHRVGRTARAGRNGRSISLVGEADRKMLKAAIKQSEADQIRHRIIPPEAVNAMLDKLNEIKDEIEEVLVEEKEEKLMRQADMELKKGQNMVEHHDEIHSRPARTWFQSEKEKEKSKSASKEAYVGSFPNAAANGSNGKDLNKDGKKEPKRGKYDGLSRKAKRRKMAIEEDQADQQSSKSTSLAIRNAKKAARPVKITESLPKTKSTSKKSSTKIGAGNKRKSAFDDNKPSKKHEGMRAKQTKVNLDKKGKSGKGKSKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HYH8</accession>
    <name>A0A1B9HYH8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_06203</name>
        <name evidence="8" type="ORF">I206_107872</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI894014">
        <property type="protein sequence ID" value="OCF48335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC73900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009554.1">
        <property type="nucleotide sequence ID" value="XM_019157914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HYH8"/>
    <dbReference type="STRING" id="1296096.A0A1B9HYH8"/>
    <dbReference type="GeneID" id="30174572"/>
    <dbReference type="KEGG" id="kpin:30174572"/>
    <dbReference type="OrthoDB" id="161814at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF73">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN CTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0187">Copper transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCF48335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC73900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="165" mass="18670" checksum="A2A921069854D167" modified="2016-11-02" version="1">MDMGSGDNNSHSCKISMLWNWYTIDSCFLSSTWHIKTKGEFVGSIIGIFFLCISIEFIRRISREYDKKLIKIAKAEIVLSTLPDIPTDQISSSSYNFRPTWIQQIIRGIAYGSQFTAAFLVMLFGMYFNGYILFAIFLGQTVGYIVFGRDTCTTSIDHIVSGTCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HYP3</accession>
    <name>A0A1B9HYP3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_05186</name>
        <name evidence="3" type="ORF">I206_107269</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="519" mass="57093" checksum="3FA82469948C783B" modified="2016-11-02" version="1">MSVRSTTPTSRPLETLKRLPPNKMTTPSAKRARVSIAREPMTPHPSSDIEEAQFPMKFTAVPIRVLHGEPMTPSTSTVAFSSSPNRRMMLSSSPTRFARTCSKSDITFDHDITLTEGTSLIFGRHRHSHSNSNKSSSSSISSSIPSHLLPLLAHPENQSTVIHLSKDASHASRVHALIELIKARESDQKDIIRIIVIGQNGMKVKITNKKRGVRLLQGQKFDLALTPHQSAELDFFGSRVLIRVPPTFAFYADEDRERLFSSSPISQRNDMLPNLESSMPPSSPPMLPIDMDDEVLSELEPEAEAIAPRLEISTAEPSAEHEEEDKQSRASSPLSPASESRLSPLPDLAEPAQPSISTEVVPEGEEEKQVKAERIEAVITKPSSRASSPILPVPSSVDLQAIIASTVVFSGSSKLSLPDLVKHMLESQPSLKEHGSEKNWSAWVGDALENNEMFGKVERHGKDASGHPLLPHYYYNPAADPDVSRAKELGALVRPLRTAQRTGGKVIDWRPVGRGRRHM</sequence>
</entry>
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        </lineage>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">CBS 10737</strain>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">CBS 10737</strain>
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    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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            <strain evidence="5">CBS 10737</strain>
        </source>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:carbohydrate metabolic process"/>
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        <property type="project" value="InterPro"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
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</entry>
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    <name>A0A1B9HZL7_9TREE</name>
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    <reference evidence="16" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Murphy C."/>
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                <person name="Saif S."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="16">CBS 10737</strain>
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    <reference evidence="17" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family. PPIase D subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC73007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009924.1">
        <property type="nucleotide sequence ID" value="XM_019157206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HZL7"/>
    <dbReference type="STRING" id="1296096.A0A1B9HZL7"/>
    <dbReference type="GeneID" id="30173854"/>
    <dbReference type="KEGG" id="kpin:30173854"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000029">
        <property type="entry name" value="peptidyl-prolyl cis-trans isomerase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000068">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0697">Rotamase</keyword>
    <keyword evidence="8" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="15">
        <location>
            <begin position="7"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="307"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00076602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCF48705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="WWC73007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="373" mass="40954" checksum="8D42BFCB503FF936" modified="2016-11-02" version="1">MPNTITYFDITIAGSPAGRLTFELYDDVVPKTADNFKHLCLGDKENASGRKLAYAGSIFHRCIKSFMLQGGDFTNGNGTGGESIYGEKFEDENFTLKHDKPMLLSMANAGPNTNGSQFFVTTVPTPHLDGKHVVFGRVRSNKGLVRRIEALPTTSDKPNEEVKIAAAGVLTSEDIAKEDEERKKAQEASSGEDIWEDYPQDEEGIDAEKADEALSVALKLKDVGTKEFKAGQFATALDKYQKALRYLDVHPVLPDDAPKEQVEGFRSARIPLLTNAALAALKCAPPAATLAMILTTRALAINDLTPAEKGKALYRRALAEIQKKEEEEAEKDLKAALECVPGDAGVLKALKDVEFRRKERKEKERKAFSKMFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HZR5</accession>
    <name>A0A1B9HZR5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Monopolin complex subunit Csm1/Pcs1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_05564</name>
        <name evidence="4" type="ORF">I206_106890</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC72926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010002.1">
        <property type="nucleotide sequence ID" value="XM_019157284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HZR5"/>
    <dbReference type="STRING" id="1296096.A0A1B9HZR5"/>
    <dbReference type="GeneID" id="30173933"/>
    <dbReference type="KEGG" id="kpin:30173933"/>
    <dbReference type="OrthoDB" id="3216420at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034506">
        <property type="term" value="C:chromosome, centromeric core domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033551">
        <property type="term" value="C:monopolin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990644">
        <property type="term" value="F:microtubule site clamp"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045144">
        <property type="term" value="P:meiotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23787">
        <property type="entry name" value="RWD_CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040349">
        <property type="entry name" value="Csm1/Pcs1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020981">
        <property type="entry name" value="Csm1/Pcs1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038608">
        <property type="entry name" value="Csm1/Pcs1_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28006">
        <property type="entry name" value="MONOPOLIN COMPLEX SUBUNIT CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28006:SF1">
        <property type="entry name" value="MONOPOLIN COMPLEX SUBUNIT CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12539">
        <property type="entry name" value="Csm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Monopolin complex subunit Csm1/Pcs1 C-terminal" evidence="2">
        <location>
            <begin position="255"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF48783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC72926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="363" mass="40302" checksum="16E5148443C4E0FF" modified="2016-11-02" version="1">MAAALGSKVIKKVGKENAPPSRTTKKTDTEDGNASDASDAVDLPRKSGKGLSKAPSSKSLNGEDDDAKELKRRLTAVTAERDRYRSQRDTYSTQFEELTKSRSDGEGLLDKYKQKAEIQSKAQNDIIASQTALMEKLQAKVKSLEKALALNEKDKELPNAGGPFDDSSTKADPKDIKVLRDELSKLKKENKAKDTEISELQKQYQVEVEYSKSLIAGKQQLNSSTNKSLGASTSTTNTTYSTNPEEAAKDAASLALYEDLTLLQIANVKIKPARIGKEEIFNCILSVDGRSLNFKLRCYTELDKSVTPPKYNKSVHYTPELLQHESEAFIKRLDYFANEFVVPRDQLGGFLLEMRAKMGEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HZW7</accession>
    <name>A0A1B9HZW7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromatin modification-related protein EAF3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Chromatin modification-related protein eaf3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I206_05610</name>
        <name evidence="16" type="ORF">I206_106844</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in deacetylation of histones, chromatin assembly and chromosome segregation. May act as a transcriptional oscillator, directing histone deacetylases to specific chromosomal domains. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MRG family.</text>
    </comment>
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        <property type="protein sequence ID" value="OCF48829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC72880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010048.1">
        <property type="nucleotide sequence ID" value="XM_019157330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HZW7"/>
    <dbReference type="STRING" id="1296096.A0A1B9HZW7"/>
    <dbReference type="GeneID" id="30173979"/>
    <dbReference type="KEGG" id="kpin:30173979"/>
    <dbReference type="OrthoDB" id="124855at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.30:FF:000004">
        <property type="entry name" value="Putative Chromatin modification-related protein eaf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000104">
        <property type="entry name" value="Unplaced genomic scaffold supercont2.8, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.30">
        <property type="entry name" value="MRG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008676">
        <property type="entry name" value="MRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038217">
        <property type="entry name" value="MRG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026541">
        <property type="entry name" value="MRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053820">
        <property type="entry name" value="MSL3_chromo-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880">
        <property type="entry name" value="MORTALITY FACTOR 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880:SF15">
        <property type="entry name" value="MSL COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05712">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22732">
        <property type="entry name" value="MSL3_chromo-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038133">
        <property type="entry name" value="HAT_Nua4_EAF3/MRG15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51640">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Chromo" evidence="14">
        <location>
            <begin position="22"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="85"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018505"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00057322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00298"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF48829.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC72880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="312" mass="36012" checksum="BCA22CC27670D1E9" modified="2016-11-02" version="1">MSGSMNQFTNDEYVLAYHGPLLYEARIILAENWDENNTLLGTVGPHYFIHYKGWKTTWDEWVPEQRLLKLNEAGFAKRRALLDAQAKKNRPPSVAGSSTASPAPASTAKGKEKGGKKNDSKKRARESAVDTEAAFLNRPEVKIVIPEVLKLQLVDDWENVTKNNQLVTLPRKPNVRELLEEYRQYVNNTKKGQDRGPRATALLSEIISGITLYFDKALGNNLLYRFERAQYVEQKRQNTDKPMSEIYGAEHLLRLFVNFGPFIAYTNIDTESLNILREYINDIMKWMIKEQKRLFVKEYESTSTHYQNMSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I015</accession>
    <name>A0A1B9I015_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_05657</name>
        <name evidence="6" type="ORF">I206_106795</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC72831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010095.1">
        <property type="nucleotide sequence ID" value="XM_019157377.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="30174026"/>
    <dbReference type="KEGG" id="kpin:30174026"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="277"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF48876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC72831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="465" mass="49645" checksum="3565CA9BBFF0E145" modified="2016-11-02" version="1">MEQQGKDTPDLARLKTNIYYQITIHSFSMSHSHNISSRLNARNESHVEKEDVVSHPDDTPADPGFPEGGYLAWSTVVGSWSLVFATFGVANTFGVFQSHYILQKYPERDSSDIAWIGSLQLFLQFMMGGVSGPLFDKGYFYPVVIGGAAIHILSFFMISLCNEFWQTFLAQGVLAGIGMGLVFVPALGVISQYFKRKRGLASGIVVTGSSAGGVVFPIMLNKLIVKVNFERGVQYTGVLIAGALVIGVSLIRPFGGVRGHKQGGPKPNAKSFFREPGYVLACIGVFFVAWGIFFPIVFLQYFAELTGASENLTFYMVAILNGASVVGRTLPNLVADKFGALNLITIMCLLSSAMCFAFFGASRSTAGLVVVAILYGAASGAFVSLLAPSIFSMAKSQAEIGTRMGITMLFLGIAALTGNPLGAAILDSNGYGASIAWSGSMVATGAALFGFAAWFTAKSKGQWKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I079</accession>
    <name>A0A1B9I079_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Lectin, mannose-binding 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_04629</name>
        <name evidence="11" type="ORF">I206_105809</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF48942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC71850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010161.1">
        <property type="nucleotide sequence ID" value="XM_019156359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I079"/>
    <dbReference type="STRING" id="1296096.A0A1B9I079"/>
    <dbReference type="GeneID" id="30172998"/>
    <dbReference type="KEGG" id="kpin:30172998"/>
    <dbReference type="OrthoDB" id="270293at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07308">
        <property type="entry name" value="lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000095">
        <property type="entry name" value="Lectin family integral membrane protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051136">
        <property type="entry name" value="Intracellular_Lectin-GPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005052">
        <property type="entry name" value="Lectin_leg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223:SF45">
        <property type="entry name" value="RE50040P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223">
        <property type="entry name" value="VESICULAR MANNOSE-BINDING LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03388">
        <property type="entry name" value="Lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51328">
        <property type="entry name" value="L_LECTIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628310" evidence="8">
        <location>
            <begin position="22"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="L-type lectin-like" evidence="9">
        <location>
            <begin position="36"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF48942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC71850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="334" mass="37583" checksum="2547DF00711D1019" modified="2016-11-02" version="1">MIRPITTFSVLLPFLVMGANAAEDTQDSLTGMIEKTTPLRTHSLAAPYVDSDLQNRWWDFGGNAIINTNKHVRLTQDRPSEKGWLWSRMPMSVQNWQIDVEYKVDGKAHNMFGDGFAMWISKDRAKEGPVFGSVDYFNGLGIFFDTYSNSRHSYQWPRVTAMLGDGKTQYDHDHDNEAHEIAGCSHNFRRQGDTPTKARLTYVKGKLLQLKLQTKYVNDWTICFEVPLDLPDNPYIGFSAATGDVSDNHDIISVNTFSATLRPQFRPVDQKPFDTIVNQGTGGKGRPSSKSSSSGGAAGWFLFILKGIGILAFIAFAIAAFRTYNAQKKQKRHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I085</accession>
    <name>A0A1B9I085_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rho guanyl-nucleotide exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_04643</name>
        <name evidence="8" type="ORF">I206_105823</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
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                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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                <person name="Shea T."/>
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                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Roberts A."/>
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                <person name="Shea T."/>
                <person name="Sykes S."/>
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                <person name="Litvintseva A."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 14">The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the SPT4-SPT5 complex. Interacts with RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the SPT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC71950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010264.1">
        <property type="nucleotide sequence ID" value="XM_019156462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I0K1"/>
    <dbReference type="STRING" id="1296096.A0A1B9I0K1"/>
    <dbReference type="GeneID" id="30173101"/>
    <dbReference type="KEGG" id="kpin:30173101"/>
    <dbReference type="OrthoDB" id="248751at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07973">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.210:FF:000002">
        <property type="entry name" value="Transcription elongation factor SPT4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009287">
        <property type="entry name" value="Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022800">
        <property type="entry name" value="Spt4/RpoE2_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038510">
        <property type="entry name" value="Spt4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882">
        <property type="entry name" value="SUPPRESSOR OF TY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06093">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025023">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01389">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="16" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Spt4/RpoE2 zinc finger" evidence="15">
        <location>
            <begin position="12"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR025023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCF49045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="WWC71950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="115" mass="12855" checksum="61C8D2643C59CACD" modified="2016-11-02" version="1">MPPKGGSRKTELRACLICSVLQSTNDFLTQGCPNCEEILEMRGSAERVAECTSVTYDGMIAMMEPSESWVARWQRIDKRMRGIYAVRVTGRPPADVIEAIESRGGVYRPRDAVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I165</accession>
    <name>A0A1B9I165_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Asl1-like glycosyl hydrolase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_04879</name>
        <name evidence="5" type="ORF">I206_106056</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010410.1">
        <property type="nucleotide sequence ID" value="XM_019156608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I165"/>
    <dbReference type="STRING" id="1296096.A0A1B9I165"/>
    <dbReference type="GeneID" id="30173248"/>
    <dbReference type="KEGG" id="kpin:30173248"/>
    <dbReference type="OrthoDB" id="5959761at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF14">
        <property type="entry name" value="ASL1-LIKE GLYCOSYL HYDROLASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628260" description="Asl1-like glycosyl hydrolase catalytic domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="3">
        <location>
            <begin position="211"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF49191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC72096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="431" mass="45593" checksum="8A4A677688A3EC3C" modified="2016-11-02" version="1">MKFSILITILPLLALSSAAPAPAVQSSSSSSVAKSGSSTSSASRSSSSSISKSTSSIKPTSSTSIKLSVSSSSSKAASSTSKISSSSSIPKSPSSSISKPISSVTSAIKTSTSSSKVSTTTSKASSTSTKASASTTKASSTSSKSSMVTSTSKAITSSISKSISASTSKISSTTSKTISTTTSSSAQTTSSSAQTTSSSAGLGLSWQSYQKLANTKGLKWYYNWSFWPMSMGDIEYVPMIWGESSINDWDGNVPTGSTYILGFNEPDQPSSAGGSNMNVTQGSLLHQKWTNKLVNKNIKIGSPAVARGGSWWFNGWLQACNGQCKFDFVPIHFYGTNANDLITYIKTFPSQGKPIWLTEVACLDFSSGQKCTLQENKDFMKISINWFESIEGKKFIERWSWFGAFPDVTDPWGLENSNGTLNDLGNYYLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I172</accession>
    <name>A0A1B9I172_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_04979</name>
        <name evidence="3" type="ORF">I206_106154</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
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            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="301"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF49835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC70115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="919" mass="100719" checksum="142A9747542590D0" modified="2016-11-02" version="1">MAGSSSPLPSPPSGIMRSASLSAHKIYSRRASAIREKRRAEALVNDTDSDEDGNSDTFLKRSKAVEDGSPISKKTKSSSEKRNIQNNQTRISPRNLSSARNHSSSSFVEARSPSPSPPPIKRFNSMETTTSSSTTSPANKRKASQKQSAPIVDIHPPSSSPPLPPDTKAPSTPPRKIKSLSKNNTPQASPSSFEDLFANVSPRKDYFDDSPSRGDNKLPTSPGAGISEGSKQRLTRPGGMRRMLTKTQSMSALPITPSKDQNEDIEESPKNAFGGSMEVSPSSAISPQRPSTPNKNLSRTKSMPESPSKSSPKNQDNSSLGVNTVTQGAGGSGGRAKRTYGGKRSMLAEVSKVNLELSNVSEDDVGISENAPEVSYAELRKKFETDNEETDNGSGNLMAELLVARAPQAVSDMRSKGENRRFMDELNCLIEGIGDPTMGISFKRTSALDIIRNMQDESWLAKMEICGQIEIVWGSLMQAGGEEYDMTMETICILFLAILIKSNTGIDQLMRNNRDQAMNLLLRNLNTKNGPLDQSQKTKLSNSASTRILASSTLNSICGMVAEQDDMDIIDDPIILKQVLDSLILETKILGDRFDLHEKGLDLLPQTDPPDSDHIYYLLQIIFRLVEGSEECKDKMEDSQTESVQALVNVVITATAVWLNVEDESSPNVSRCIGQILQLLIVLATSSPEWIRSFLVIRGASTALLRSLLQREHIIPVQTSTAPKAREEESRATEVEMVEQAEPDTTLLQRDFLCTILVLLIQAIRTDAKVVQILANTSMSSRCKGNFGCLRKCNCLDQLSFTHHLSQIYSDYQQNDDDIFAKAITGYLALVIINFLLSNSSIEQESLSPLPGQNVKGKLEGLRGSLRGLLYEVHHNLRQILSGPSDENESAEDDGEDEIEMENVKEALKNLDDIISKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I2Y3</accession>
    <name>A0A1B9I2Y3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_04402</name>
        <name evidence="11" type="ORF">I206_104023</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011093.1">
        <property type="nucleotide sequence ID" value="XM_019156135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I2Y3"/>
    <dbReference type="STRING" id="1296096.A0A1B9I2Y3"/>
    <dbReference type="GeneID" id="30172771"/>
    <dbReference type="KEGG" id="kpin:30172771"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043020">
        <property type="term" value="C:NADPH oxidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016175">
        <property type="term" value="F:superoxide-generating NAD(P)H oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042554">
        <property type="term" value="P:superoxide anion generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000091">
        <property type="entry name" value="NADPH oxidase (NoxA), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000778">
        <property type="entry name" value="Cyt_b245_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF39">
        <property type="entry name" value="FAD-BINDING FR-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00466">
        <property type="entry name" value="GP91PHOX"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01169">
        <property type="entry name" value="NADPH_oxidase_subgroup_(NOX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="9">
        <location>
            <begin position="242"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF49874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC70077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="560" mass="64715" checksum="4F41B9250FD6BE89" modified="2016-11-02" version="1">MQISELIEKAKVELSGRKLIWNVLWYGIHFSLFGYGWYSQQTNLKLSTLNKLKFSVWISRGAGLVLAFDGGLILIPVLRNLLKLIRPKLMWLFPVDENIWFHRQVAYQMIFWTMIHTTAHYVNFINVERTQVRKQTAWEIHYTQPGGFTGHVMLLILFLMYTTAHSSIRKQCFEVFWYTHHLAFFFMIGLYTHATGCFVRDSINPNYISTFPFYSTNHCLGYESWRFTIWSGILYFGERLYSEIRSKRKTEIQKIYLHPSNVVEIRFFKSSFKFKAGQWIFVNIPEISKFQWHPFTISSAPEDPYISVHIRQVGDFTESLGNRLGSIQSQIPIGEKSEFDSNSNPNLGKRKDYIEINPNSIGKGMPLLRIDGPFGAPAEDVLNSEVAVLIGAGIGVTPFASILKHIWYAQRSGQLGVLRRVEFIWSCKDTGTFGWFQTLLEELEASQSDPNFLHISVYLTQKLDSDTVQNITINDIGAKYDPLTLLQSRTLFGRPNYKLFFNNLISNIENGNYLPGRESTLKTRLGIYFCGPNSLARIIRKEAFSIPTKSVNVKFLKEHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I379</accession>
    <name>A0A1B9I379_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dipeptidyl-peptidase V</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_04533</name>
        <name evidence="9" type="ORF">I206_103894</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9C family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF50002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC69950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011221.1">
        <property type="nucleotide sequence ID" value="XM_019156263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I379"/>
    <dbReference type="STRING" id="1296096.A0A1B9I379"/>
    <dbReference type="GeneID" id="30172902"/>
    <dbReference type="KEGG" id="kpin:30172902"/>
    <dbReference type="OrthoDB" id="416344at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000028">
        <property type="entry name" value="S9 family peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776:SF13">
        <property type="entry name" value="DIPEPTIDYL-PEPTIDASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776">
        <property type="entry name" value="SERINE PEPTIDASE S9 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628344" description="Dipeptidyl-peptidase V" evidence="6">
        <location>
            <begin position="18"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="7">
        <location>
            <begin position="511"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF50002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC69950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="743" mass="82627" checksum="FE42A83F2E27BE44" modified="2016-11-02" version="1">MRISILTCLGLVAAAHAKRLQDVFTPKDMLAAPRPQPAIASPGGKHAISVVDQWDPKTDKTHRSVYLLSLNTTQTLSPVSLLNTTSSETSQLVWLDASSFAYLNGSSLFSYSIDVRTASQSALLDRTKEILTFPEGVNPTDLTYEAKSGTLAFSGQIWESSGDFVDTAKYDEKWERRGDSALVYDELFVRHWDEWRTPGKVWTVGLTKIAKDAGVWASSSSGKEQTFVNILKDTGLYSQMDPVGSFTLTAGYLAVAIKAPHLNYATHTREDIYLVALPGQSASSSPRHLTPHSHGAISALTFSPNGKQLAWLEMQKDGYESDKRVIVVHEEGKGTRRWTEDWDRSPNSVTWSHNSDSLYFTAEHHGRVLPYHLTHPGHLPTPLYFNGTTTSITPLANHTILLSQQSLTSPSDDFILTIPRRQTGQAGDAGDQDGDKLPKDALKRLTAWSAAYIKDKLEGLEGEEFWFEGAEGKEVMGWAVKPRGWEAGQKRAWPLAFLIHGGPQGAWEDSWSTRWNPAVFASQGYFVVAINPTGSTGYGQDFTDAIQGDWGGKPFKDLLAGYQAALSRYPEIDPDRTAGLGASYGGYMVNWINGHNDHFGFKALVCHDGVFDTVTTYFSTEEVWFPTQDFAGTPLTHRANYERWSPVNHAIEWTTPELVIQGGKDYRLENSQGLGAFTALQTQGVPSRFVYFPDENHWVLKPHNSLKWHHEVFRWLDEWVGRAHEEASAEELVNLGLDFVVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I3A1</accession>
    <name>A0A1B9I3A1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_04550</name>
        <name evidence="5" type="ORF">I206_103877</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF50019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC69933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011238.1">
        <property type="nucleotide sequence ID" value="XM_019156280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I3A1"/>
    <dbReference type="STRING" id="1296096.A0A1B9I3A1"/>
    <dbReference type="GeneID" id="30172919"/>
    <dbReference type="KEGG" id="kpin:30172919"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF8">
        <property type="entry name" value="BENZIL REDUCTASE ((S)-BENZOIN FORMING) IRC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF50019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC69933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="288" mass="31693" checksum="4F56A5CCD8418E3A" modified="2016-11-02" version="1">MTSQIPDERTVVIITGANSGIGYQTALSLIRSVDKGYTIFIGARSKSKAEEAIFTLKKEKEVKLDLSNLIPLVIDLESDESIKNCYDYVKSKTNIVDVLVNNAGSSFDKIGLEMGLTPRQIFQKTFEINITGTHLLTEIFLPLLIKSKNGKILFITSGSSSLNRTEDLNFSLNKSPSSGWPKKIENDDGIGMMGGFLAYKTSKLGLNMIMREWFRILKNDKNLKVFGINPGTVLTNLGGDKEQLKKWGAKDPSTSGEFIKSVIQGDRDKDVGKIVNPPGAPTGDILPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I3G8</accession>
    <name>A0A1B9I3G8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_04549</name>
        <name evidence="3" type="ORF">I206_103878</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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                <person name="Yurkov A.M."/>
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                <person name="Heitman J."/>
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                <person name="Litvintseva A."/>
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                <person name="Chen Y."/>
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                <person name="Yurkov A.M."/>
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                <person name="Litvintseva A."/>
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                <person name="Hansen M."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
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            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Dewar J."/>
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                <person name="Griggs A."/>
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                <person name="Imamovic A."/>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
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                <person name="Young S.K."/>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="Mohammad A.W."/>
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                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Murphy C."/>
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                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Murphy C."/>
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                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
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                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Murphy C."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
    </feature>
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        <location>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC68549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1042" mass="114644" checksum="3984ABD1C8D41547" modified="2016-11-02" version="1">MGGFSIHPLLPSIKAKITAIHQYDDRLYVGLLNGTLQIYSYNISKDDNLPRVELLKTHTLGKRQMDQIGILGESNQIIILSDTVVTLYSLPELTKKGSIVLNQARSAHCFAHTKYSTQGKKGESSTGISSKELLVVGCRKKVVVYGAGKGGLKEGWELNLPHSPRTIIFPSPPSTGIPETVHLLFTPQTSVLLHINPSSSANRLNVSDTTTFPPPPSSSASLIAEEGGSTGITMGMGALTGLGGYVGLGAKSAAPLGTSTVGGEVLLARDDTGAFLSSEGNYTRTESLQWPGPPDALAFSNPHIYSVVPVLPSSSTSSSQTIPVPTVQIHLAPTLTLRQAFKLPEPPTGGQAVSHMINTFKASPSLIPAEVMNPSTKMLIVSTPTDRHLSQAEGSSIWTLQSGDIGEEVDQLVKEGRVSDAIGLVEAVGEVGLSPSRRLPHLKTLQAVTQMAKGEYQSAMEAFLIFNVNPALVLSLYPAEIISGKLHVPKDQWMDLFGAVPEAKLQPETTVEREDSTAKGILKSVAGLGGLTKKGSVNGLRELGDNASIRSGKSIDKNADQEKVPIMKEEDAVPPRAALEALMYFLSDRRQKLAGAMATNPLPIEADYPPLSSLSAETQHNLPSTPFSELTPEQLLRIAQVIYTGLIKVYLVARPVLVGSLCRIENWCDVEEVEELLKAQKKFGDLIDLYQGKKMHGKALKMLHELAKDEEDKLDRYPPTIRYLQKLGPSQLDLILESSKWIFEEDPKMGLQIFTADEPEVESLPRSEVMRFLDKTNQEACIGYLEHIIHTVGEEGPDFHDKLAELYHARVKGEQGKKGDADIREANYEIFLEFLQSSTTYRPFRLISKLAAEEMPEARAILLGRMGKHEEALRIYVYNLEDYQAAELYCVRNYPSNDEIFLLLLRIYLRPISGKEPLLSPSLTLLSKYSNSLEPKQVLDLLPPLITIQQVDKFLLSTIRDTFKKQNENKLFKNLIKSRKEELDRILLGLENKRIRITDQRICPQCHKRLGNSAIAVHAPRGEVTHLHCKDSFSTKLARLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I617</accession>
    <name>A0A1B9I617_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_03032</name>
        <name evidence="12" type="ORF">I206_102679</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF50970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012189.1">
        <property type="nucleotide sequence ID" value="XM_019154786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I617"/>
    <dbReference type="STRING" id="1296096.A0A1B9I617"/>
    <dbReference type="GeneID" id="30171401"/>
    <dbReference type="KEGG" id="kpin:30171401"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="359"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="507"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="110"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCF50970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC68745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="575" mass="63395" checksum="8E3756027630F7D0" modified="2016-11-02" version="1">MNHVRDLEAGRVSTATASMYQREGDAMREDEMEPEGPLDDITIQPPSSSGTENNQLQKTALKRSNQVDDGNELGPSPTSLSTVEARRVTASYPTSPANPRNWPESRKMGITVTLLLTGFISTAGSSIGIPGMHAVRDEFGVGFRVGVLIPGAYVLGLGTGPFVFAPISELYGRQIAYISSQITYCIFFLGTGFSNNMATLIVLRFFCGVFASVPPSLGVATCADMFEPSQRGKPISIYALGPLSGPILGNMLGYWLLYFGWRWAYYFMTIVATLNTILLLVVMRETYAPVIQKIMVYNSIHTNSKSKSPSLIKMSDKLNPINWVPDLSWMPAMVTKSEMLVVYGRAFSRPPRLLFTNPVAFMFSMYYAYLYGLIYLFLTTIPLLFGKPPFSQTDLFSYEWPQGTLPLSYLGLGLGFCSAAVVAANLQDRIYKYLSKRNGDKGQPEYRLVLTACGMITMPIGLFIYGWTANSHTHWIAPIIGQYLIGIGLVLPFNTIQNFLVDAFHPYSAAAIAGATAARSIVACILPLFASEMFQKLDWGWGNTLLACVAILGIPAPFIMFLHGKQLRERYAFQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I642</accession>
    <name>A0A1B9I642_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_03055</name>
        <name evidence="3" type="ORF">I206_102702</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I692</accession>
    <name>A0A1B9I692_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_03109</name>
        <name evidence="3" type="ORF">I206_102754</name>
    </gene>
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        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF51044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC68819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012263.1">
        <property type="nucleotide sequence ID" value="XM_019154860.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="30171478"/>
    <dbReference type="KEGG" id="kpin:30171478"/>
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    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
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        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF51044.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC68819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="548" mass="60214" checksum="68690DA3D18D674A" modified="2016-11-02" version="1">MPPLFTSTSWTTLIRKAAVAIMYAPKPAIAIKATPKRTINNIQKARQVFHQVIHSSFPSLSTPAHQLNYATIPIRTSARGFASSSKASHTSQRLSPVRQSLQSTGSRPKWVNGPSIPANVGLGKARNFSSAPHVQAMQSHVPMVFRAFATLLDDEDKKFSLKGLPKASRYTPYSKSRLARRQRTKRVNSNHSIDSSFIEDLKHFFPIPTRASSQAVIVTLPVEPETLVTEGKTTILALPLSPSLEALLSPMAQISYNDTSIGISILAKLTEGLFPIHNAFSLHSSTRIIPLLTKLDGLGVLDQHPGLANTQAEVVHDTDGQPDILRLIFIDRSVSDVKTLLGESLRPSEEGEWWALYEEQPDRKMELNQNERKEIMEQWDNSSLKTVEPSTSESLLFPTLDMSVNHHHQEMEFNHGTNEVIFDISESILSSPSNSWPSSGSSTPSPIETPLSDEEGSSMSLSSSTESLTASLLSRLSDTSNDESVWSVYPSDSDSDIESSFSEAEAEDWNTVEQLVTSSPSEEDGNEGQVMVTWSGSGEGFGFLAQPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I695</accession>
    <name>A0A1B9I695_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM2-LSM8 complex subunit LSM8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LSM8</name>
        <name evidence="11" type="ORF">I206_03102</name>
        <name evidence="12" type="ORF">I206_102747</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
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        <property type="protein sequence ID" value="OCF51037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC68812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012256.1">
        <property type="nucleotide sequence ID" value="XM_019154853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I695"/>
    <dbReference type="STRING" id="1296096.A0A1B9I695"/>
    <dbReference type="GeneID" id="30171471"/>
    <dbReference type="KEGG" id="kpin:30171471"/>
    <dbReference type="OrthoDB" id="10263346at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
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        <location>
            <begin position="1"/>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF51037.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC68812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="95" mass="10706" checksum="2A0497C49601D150" modified="2016-11-02" version="1">MASIENYVDHLVQVILYDGRIIVGKLKGYDPRSNLILADCVEREYSIDQGVEMIPLGLYMIKGDNVALVAELDEEKDSTIDYTEIKAEPLGEIHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I6C5</accession>
    <name>A0A1B9I6C5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_03133</name>
        <name evidence="4" type="ORF">I206_102778</name>
    </gene>
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        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF51067.1"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        </location>
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        </location>
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        <location>
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        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF51067.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC68842.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="423" mass="43154" checksum="19BACD1CF8474C5E" modified="2016-11-02" version="1">MVSTFALISVLSALTATVSAVPCVQFDSSWNLYAFGGSEDVKLGANTTWAQPQASALSTSGRPPWTGTNSQCILSQTNNALYVVGGDSSDLSKIYVYNFASDSWSTQTTSGAPSDLGNSRSSSVLDHDTNVIYTLTTSSGLYQLDMSSVTNSAQSSALAWEAVENPSFSVDGYSVTATQAANHIFYFGVPNTAAGSANLFVVHYAYFQPTAQAFNGSSQFPDTAGQAISIPTESDSVPYSMVFVPNDFSNTYIATHWTDLGDYSVTSDAPFAVDLINSTQTIAAPTSQDKTASYAASPYDLVQIDTSGAIYYYANPVNGDYTVSSGGSWEKLSYSLTGGSTGSSNSTTSAAASGSASASASAASGSASASASRTASGSKSASASGSAASASSSSKSGAGKSVARGDLMGLTIGIVALGASMFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1B9I6C8_9TREE</name>
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        </recommendedName>
        <alternativeName>
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        </alternativeName>
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        <name evidence="18" type="ORF">I206_102779</name>
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        <dbReference type="NCBI Taxonomy" id="1296096"/>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
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            <taxon>Tremellales</taxon>
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        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a nutritional role via nitrogen acquisition in the environment. Contributes to the central nervous system invasion by enhancing yeast sequestration within microcapillary beds (such as within the brain) during hematogenous spread, thereby facilitating blood-to-brain invasion by C.neoformans. Affects fitness within the mammalian phagosome, promoting non-lytic exocytosis while delaying intracellular replication and thus reducing phagolysosomal membrane damage, events that could facilitate cryptococcal dissemination when transported inside macrophages. Urease activity is also associated with the regulation of key intracellular metabolic pathways, including melanin biosynthesis, polyamine biosynthesis, as well as intracellular levels of proline and reactive oxygen species.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>urea + 2 H2O + H(+) = hydrogencarbonate + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Ni cation</name>
            <dbReference type="ChEBI" id="CHEBI:25516"/>
        </cofactor>
        <text evidence="13">Binds 2 nickel ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homohexamer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="12">Carbamylation allows a single lysine to coordinate two nickel ions.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="3 11"/>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF51068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012287.1">
        <property type="nucleotide sequence ID" value="XM_019154884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I6C8"/>
    <dbReference type="STRING" id="1296096.A0A1B9I6C8"/>
    <dbReference type="GeneID" id="30171503"/>
    <dbReference type="KEGG" id="kpin:30171503"/>
    <dbReference type="OrthoDB" id="1708534at2759"/>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035550">
        <property type="term" value="C:urease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00375">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00407">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00390">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.280.10:FF:000001">
        <property type="entry name" value="Urease subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.150.10">
        <property type="entry name" value="Urease, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.280.10">
        <property type="entry name" value="Urease, gamma-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01953">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008221">
        <property type="entry name" value="Urease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011612">
        <property type="entry name" value="Urease_alpha_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017950">
        <property type="entry name" value="Urease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005848">
        <property type="entry name" value="Urease_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017951">
        <property type="entry name" value="Urease_asu_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002019">
        <property type="entry name" value="Urease_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036461">
        <property type="entry name" value="Urease_betasu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002026">
        <property type="entry name" value="Urease_gamma/gamma-beta_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036463">
        <property type="entry name" value="Urease_gamma_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050069">
        <property type="entry name" value="Urease_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009671">
        <property type="entry name" value="PRK13192.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009686">
        <property type="entry name" value="PRK13207.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01792">
        <property type="entry name" value="urease_alph"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00193">
        <property type="entry name" value="urease_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33569">
        <property type="entry name" value="UREASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33569:SF1">
        <property type="entry name" value="UREASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00449">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00699">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00547">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001222">
        <property type="entry name" value="Urease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01752">
        <property type="entry name" value="UREASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51278">
        <property type="entry name" value="Urease, beta-subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54111">
        <property type="entry name" value="Urease, gamma-subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00145">
        <property type="entry name" value="UREASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51368">
        <property type="entry name" value="UREASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 11 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11 13" id="KW-0533">Nickel</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Urease" evidence="16">
        <location>
            <begin position="397"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14 15">
        <location>
            <position position="588"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="13">
        <location>
            <position position="485"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="13">
        <location>
            <position position="485"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="514"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="540"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="628"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="12">
        <location>
            <position position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00030395"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00056221"/>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR001222-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-52"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OCF51068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="WWC68843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="835" mass="90951" checksum="C08E39C90CE6E97B" modified="2016-11-02" version="1">MHLLPREQDKLILSNLGFLAQRRLARGLALNRAETIALISSQLHEFIRDGNHSVAELMDLGKKVLGRRHVMVGVGESIHDIQVEGTFHDGSFLVTVHDPICSDDGNLFNALYGSFLPTPSDDLFPLPEQSKYLAGSVICLKSKLTLNVDKKKIMLEVKNIGDRPIQVGSHYIFLETNPALVFDRVLSFGYRLNIPAGTAVRFEPGEKKTVNMVEFGGHKRLLGGSAISSGVLDITNDEERKARLEELVKEGNFGNKRQQEVKEGKIIEMDREVYASMFGPTTGDKVQLADTDLWVEVEKDYTIYGEECKFGGGKVLRDGQGQASNRSDEEVLDLLITNALIIDWTGIYKADIGVKNGNIVGIGKAGNPDTMDNVTPGMIFGSSTEAIAGEKLIVTAGALDAHVHYICTQLWSEALASGITTLIGGGTGPADGTKATTCTSSKFYMETMMHATDTIPLNFGFTGKGNDAGTKGLKDIVEAGACGLKLHEDWGSTPECIDRALIVGDDYDVQVNIHTDTLNESGYVESTLAAIKGRTIHTYHTEGAGGGHAPDIIVVVEQENVLPSSTNPTRPYAMNTLDEHLDMLMVCHHLDKSIPEDIAFADSRIRAETVAAEDVLQDNGAISMISSDSQAMGRIGEVIARTWRTAAKMKEVRGALEGDAELRDNERVKRYIAKYTINPAITHGMSHLIGSVEVGKLADLVIWKPETFGAKPETVIKGGVIAWAQMGDANASIPTVQPVYGRPMWGCQPDVAPRCSIVWVSQASVDNGTVEKYGIKKRAEPVKNCRKIGKKDMKLNNYKPKMSVDPETYEVMADGVLCDAPPATHLALTRKHFVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I6F7</accession>
    <name>A0A1B9I6F7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_03191</name>
        <name evidence="3" type="ORF">I206_102838</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF51125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012344.1">
        <property type="nucleotide sequence ID" value="XM_019154941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I6F7"/>
    <dbReference type="STRING" id="1296096.A0A1B9I6F7"/>
    <dbReference type="GeneID" id="30171560"/>
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        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="21"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF51125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC68902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="246" mass="27831" checksum="1C2C50FEE68949BF" modified="2016-11-02" version="1">MSDEDTTTKPVMDKVYNDEGADITLLSSDNVAFKVHKYHLQSHSPVFNDMLMTCSTDIPIINLSDTISENSGAIRIFLDIIYNKQIELKFENLGHFSNCVSFTHKYNCGVILSALSYISWRFLDPPGSLISPRYIYTLAGDLDNPTLAAQAIRVSSMWGMPDLKAVKYPDNWLNANQEILMKAGGSLGISEGGMMDPTAWPIWEYDRISQIYLVALNKVHRRFPLYVNHSFGDQAAKYFLELMKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I6G0</accession>
    <name>A0A1B9I6G0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Nascent polypeptide-associated complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I206_03164</name>
        <name evidence="16" type="ORF">I206_102810</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="12">Part of the nascent polypeptide-associated complex (NAC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the NAC-beta family.</text>
    </comment>
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        <property type="protein sequence ID" value="OCF51098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012317.1">
        <property type="nucleotide sequence ID" value="XM_019154914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I6G0"/>
    <dbReference type="STRING" id="1296096.A0A1B9I6G0"/>
    <dbReference type="GeneID" id="30171533"/>
    <dbReference type="KEGG" id="kpin:30171533"/>
    <dbReference type="OrthoDB" id="8033832at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22055">
        <property type="entry name" value="NAC_BTF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.30:FF:000003">
        <property type="entry name" value="Nascent polypeptide-associated complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039370">
        <property type="entry name" value="BTF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10351">
        <property type="entry name" value="TRANSCRIPTION FACTOR BTF3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0678">Repressor</keyword>
    <keyword evidence="10 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NAC-A/B" evidence="14">
        <location>
            <begin position="34"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="131"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="147"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCF51098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="WWC68874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="175" mass="18561" checksum="F3C5B922E2C838C5" modified="2016-11-02" version="1">MDKDKLAKLQAQVRIGGKGTPRRKQVKKSVTASQGDDRKLQAALKKLGVQPITGVEEVNMFKEDGNVLHFGAPRVHAALPSNTLAVYGPGQTKELTELVPGILNQLGPDSLANLRRLAESYQSMTARQAAAAAAAGGAGAEESKEGGDDEIPDLVENFDEAGEGEKKDADLEELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I6G5</accession>
    <name>A0A1B9I6G5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_03178</name>
        <name evidence="3" type="ORF">I206_102824</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF51112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
                <person name="Chen Y."/>
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                <person name="Litvintseva A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
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                <person name="David-Palma M."/>
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                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
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                <person name="Cuomo C.A."/>
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                <person name="Heitman J."/>
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                <person name="Young S.K."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I7S9</accession>
    <name>A0A1B9I7S9_9TREE</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
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    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="19">CBS 10737</strain>
        </source>
    </reference>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 10737</strain>
        </source>
    </reference>
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            <text>[phosphate](n) + ATP = [phosphate](n+1) + ADP</text>
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            <dbReference type="Rhea" id="RHEA-COMP:9859"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
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            <dbReference type="Rhea" id="RHEA:19574"/>
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        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="10">Belongs to the VTC4 family.</text>
    </comment>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00075894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OCF51632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="WWC70856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="850" mass="96374" checksum="622753B113615B6D" modified="2016-11-02" version="1">MKFGRRIKDSRYAEWADQYIDYGGLKKQIKSDLPWNDTAEADFIQSLKNELAKCEKFQREKSEELMSKISTLEKEVLGLVEKAGLQEDEDDVEEIGSGRTPGDVERHVDSHRDDDGGSDDDDDDDDASSDISIDAIEERFRELEEEVAVLVADVHDLALFTKLNFTGFIKIVKKHDKLTGFSLKPTFNKEFLERHPFYRMNYDPLIVKLSKLFDLVRTRGHPIEGDSSAGGNQNAFVRSTTKYWVHDENIVPLKLAIMKHLPVLVFDSNKEFSKADAAITSIYFDNEELELYLGRLEKTEGAEAIRMRWYGDVTGITIFVERKTHREDWTGEKSVKERFTIKEDKMNAYLAGHYTMDDEFDALVKKGKKTEKEVEGMKQLANEIQYAIITRKLRPVMRTFYNRTAFQLPGNASVRISLDTELTMVREDNFDGNDRTNGNWRRTDIGIDHPFSNIANSEKELFPYGVLEVKLATKVGEEPPQWIRDLINSHLVEAVPKFSKFIHGCASLLPERVDLVPFWLPQMDQDIRKPVSAKSKVLIERPHSNTHSTASNTNSAIHSPARSSQPSYHEPVSEGEEDEEFLIATAKNEDEHLRLPPGAAAEARAARDFREKKLRDEANLQASSVNGRSSSTSQKPNGEIERRNSSNKYDPSLRIDPLASSDRFDKNLSLLDAKSLKKLNEAAAQSGKDGKLNGKSNGQAPIQEDSEDEHEHEIDDEEDIQGDQVIYVDQFRAPPGKRIAIPVRVEPKVVFAAERTFLKWSHFAILLSGVSIGLLNFIDPRDSVGMLSALLFTITALLAIVYSGGMYVYRILKLRKRMAIDYHDKYGPTLLCAALIGSVLVNLVLRLREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I7Y4</accession>
    <name>A0A1B9I7Y4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Splicing factor 3A subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_02319</name>
        <name evidence="12" type="ORF">I206_104780</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SF3A2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012823.1">
        <property type="nucleotide sequence ID" value="XM_019154083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I7Y4"/>
    <dbReference type="STRING" id="1296096.A0A1B9I7Y4"/>
    <dbReference type="GeneID" id="30170688"/>
    <dbReference type="KEGG" id="kpin:30170688"/>
    <dbReference type="OrthoDB" id="10250970at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2690:FF:000003">
        <property type="entry name" value="Splicing factor 3a, subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052092">
        <property type="entry name" value="SF3A2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031781">
        <property type="entry name" value="SF3A2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205:SF0">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16835">
        <property type="entry name" value="SF3A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="U1-type" evidence="10">
        <location>
            <begin position="51"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCF51604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC70828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="218" mass="24919" checksum="EE896A55A1602B6B" modified="2016-11-02" version="1">MDYQNRAGANKGSGGVAGASETAVDRRERLRKLALETIDLAKDPYILRTHLGTLECRLCLTLHVNEGSYLAHTQGKKHQTNLARRAARDNKDASLMIQAAPAAQQVKKKVFVKIGRPGYKIIKIREPVSQRMGLLFTVSLPEIKEGERPRKRFMSAFEQRREIPNRAFQYLVLAAEPYETIAFAIPSKEMVDQEEDPESVWEHWDQDEKVYSCQFLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I803</accession>
    <name>A0A1B9I803_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calpain catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_02339</name>
        <name evidence="5" type="ORF">I206_104800</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012843.1">
        <property type="nucleotide sequence ID" value="XM_019154103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I803"/>
    <dbReference type="GeneID" id="30170708"/>
    <dbReference type="KEGG" id="kpin:30170708"/>
    <dbReference type="OrthoDB" id="2565865at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628410" description="Calpain catalytic domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Calpain catalytic" evidence="3">
        <location>
            <begin position="54"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF51624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC70848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="276" mass="31002" checksum="0D7D5724E4946382" modified="2016-11-02" version="1">MTFFLLCLVPLLGLGFTIAPLSTASPVDLGVSATEQIVKRGDHPLWRPQPQYIDIKADKFEDDWLLAGAAALANTDYRKIQDLFSNVTDPKSNVDEVTVKIWNNGEWQKWNKGKEGNGPPSKEHKVVYTDITADYSGANQNWWIAALENAFIQEGGYNGITPNGFAKGDPHIALEMMTGSSAKLYNVNEMSRDTYEKDLWEALGKAQQQPICIKTNDKTDAIALEKKRWYAVLQVQGESHARQVYIWDFKTGLKVAIEYELLADDIGYYVHQEGPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I8M5</accession>
    <name>A0A1B9I8M5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA polymerase I termination factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_02592</name>
        <name evidence="8" type="ORF">I206_105052</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC71099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013095.1">
        <property type="nucleotide sequence ID" value="XM_019154355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I8M5"/>
    <dbReference type="STRING" id="1296096.A0A1B9I8M5"/>
    <dbReference type="GeneID" id="30170961"/>
    <dbReference type="KEGG" id="kpin:30170961"/>
    <dbReference type="OrthoDB" id="39591at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051651">
        <property type="entry name" value="DMTF1_DNA-bind_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46380">
        <property type="entry name" value="CYCLIN-D-BINDING MYB-LIKE TRANSCRIPTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46380:SF2">
        <property type="entry name" value="CYCLIN-D-BINDING MYB-LIKE TRANSCRIPTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="6">
        <location>
            <begin position="329"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="329"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="381"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="540"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="78"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
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        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
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            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
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            <begin position="545"/>
            <end position="558"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
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            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF51876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC71099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="573" mass="65721" checksum="A308016CD468B7E5" modified="2016-11-02" version="1">MEGMFLSPTAELSSSIVAEPSNGVEAVPKKKRSREEKEARREAKRLKKEKKEKAAEVNQPTAQLNDVFTDNGAQAAHVIEEQEKKEDKEEKAKRKAEKAERKIEKQKVKADLESSDTQKINGKIPKQATSKKIVSSKQSVPFVEIPTTQVKKRNRSQTTPLVSLSQAGPSNPSTPKRSIITSRAVRPPSTVKSRASSSSQTPSKRRKVENEVDDATLRATLTDQSSMEDWLANNWVSDKELGRLERLGILRYKKGKLTEDEKIAIRKVLETYQKVHRLNTEQLVDTIMAGATTFPSGREGWQAFWLELSAAVPGRPGRYVLKMVQRMYNPNGHKGHFTPEEDAMLIRAYELHPNQWGKIAEIVERTYHDCRDRYTKELRHHNTRVTGEWSNEEIQNLLDCIKKMNRSLGRDEMESEGIPWELVVKEMGGTRTVVQCRKKWSDDIYPTKAWGWEQGHKRENDYALIKRLEILNYPSEKHIVWKQVYDESLKHMKIHQVRQMYYRLKAKIPQADNLTFPELVKRLRGAAESLKSLCRPIRPSKGVIESDDEKDDDGNEQDTIDKGDNEVLSESDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I969</accession>
    <name>A0A1B9I969_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_02678</name>
        <name evidence="3" type="ORF">I206_105136</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
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                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
                <person name="Sun S."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
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                <person name="Imamovic A."/>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
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                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
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                <person name="Birren B."/>
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                <person name="David-Palma M."/>
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                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
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                <person name="Sun S."/>
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                <person name="Heitman J."/>
                <person name="Sun S."/>
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                <person name="Zeng Q."/>
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                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="29">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="28">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="29" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="29">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21 22">The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 22">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:21257"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 22">
            <text>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21968"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="EC" id="4.2.3.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20 21 22">
            <text>shikimate + ATP = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 22">
            <text>shikimate + NADP(+) = 3-dehydroshikimate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17737"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21 22">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="21 22">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="21 22">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="21 22">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21 22">In the 2nd section; belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the 2nd section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21 22">In the 3rd section; belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21 22">In the 4th section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21 22">In the C-terminal section; belongs to the shikimate dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="22">In the N-terminal section; belongs to the dehydroquinate synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21">In the N-terminal section; belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.4" evidence="21"/>
    <dbReference type="EC" id="2.5.1.19" evidence="21"/>
    <dbReference type="EC" id="2.7.1.71" evidence="21"/>
    <dbReference type="EC" id="4.2.1.10" evidence="21"/>
    <dbReference type="EC" id="1.1.1.25" evidence="21"/>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013462.1">
        <property type="nucleotide sequence ID" value="XM_019153301.1"/>
    </dbReference>
    <dbReference type="STRING" id="1296096.A0A1B9I9Q7"/>
    <dbReference type="GeneID" id="30169898"/>
    <dbReference type="KEGG" id="kpin:30169898"/>
    <dbReference type="OrthoDB" id="197068at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08195">
        <property type="entry name" value="DHQS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01065">
        <property type="entry name" value="NAD_bind_Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00464">
        <property type="entry name" value="SK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1090.10:FF:000007">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000135">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000026">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000007">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.65.10.10:FF:000007">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.65.10.10:FF:000008">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="entry name" value="Enolpyruvate transferase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00210">
        <property type="entry name" value="EPSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03143">
        <property type="entry name" value="Pentafunct_AroM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00109">
        <property type="entry name" value="Shikimate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016037">
        <property type="entry name" value="DHQ_synth_AroB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056179">
        <property type="entry name" value="DHQS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008289">
        <property type="entry name" value="Pentafunct_AroM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010110">
        <property type="entry name" value="Shikimate_DH_AroM-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000623">
        <property type="entry name" value="Shikimate_kinase/TSH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023000">
        <property type="entry name" value="Shikimate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01356">
        <property type="entry name" value="aroA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01357">
        <property type="entry name" value="aroB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01093">
        <property type="entry name" value="aroD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01809">
        <property type="entry name" value="Shik-DH-AROM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090">
        <property type="entry name" value="AROM/DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090:SF5">
        <property type="entry name" value="PENTAFUNCTIONAL AROM POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24621">
        <property type="entry name" value="DHQS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000514">
        <property type="entry name" value="Pentafunct_AroM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01100">
        <property type="entry name" value="SHIKIMTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00104">
        <property type="entry name" value="EPSP_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01128">
        <property type="entry name" value="SHIKIMATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 21 22" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="16 21 22" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="13 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 21 22" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 21 22" id="KW-0418">Kinase</keyword>
    <keyword evidence="17 21 22" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 21 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18 21" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="14 21" id="KW-0521">NADP</keyword>
    <keyword evidence="10 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15 21 22" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 21 22" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 21 22" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="3-dehydroquinate synthase N-terminal" evidence="25">
        <location>
            <begin position="85"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="3-dehydroquinate synthase C-terminal" evidence="27">
        <location>
            <begin position="198"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Enolpyruvate transferase" evidence="23">
        <location>
            <begin position="423"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="26">
        <location>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I9U6</accession>
    <name>A0A1B9I9U6_9TREE</name>
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            <fullName evidence="5">Rgp1-domain-containing protein</fullName>
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        <name evidence="2" type="ORF">I206_01605</name>
        <name evidence="3" type="ORF">I206_103391</name>
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        <name type="scientific">Kwoniella pini CBS 10737</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 10737</strain>
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    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
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        <property type="protein sequence ID" value="OCF52316.1"/>
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        <property type="protein sequence ID" value="WWC69452.1"/>
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        <property type="component" value="Chromosome 4"/>
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        <property type="entry name" value="Rgp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12507">
        <property type="entry name" value="REDUCED GROWTH PHENOTYPE 1 RGP1, YEAST -RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF08737">
        <property type="entry name" value="Rgp1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="119"/>
            <end position="204"/>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
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                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
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                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
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                <person name="Hansen M."/>
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                <person name="Imamovic A."/>
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                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">CBS 10737</strain>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
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                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="McCowan C."/>
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                <person name="Pearson M."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Necessary for protein synthesis in mitochondria. Functions as a ribosome recycling factor in mitochondria.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRF family.</text>
    </comment>
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        <property type="protein sequence ID" value="OCF52498.1"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1296096.A0A1B9IA81"/>
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    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="111"/>
            <end position="255"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF52498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC69269.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="259" mass="28035" checksum="A57DB2FD352760DE" modified="2016-11-02" version="1">MIRPSFARTALRVAIRPVSGPSIPAQAIFIPSTTRLFTSTPLILKKNKGANTKSPKQKIRVVEDDEAGANDDPGAGEVVISEVLEKTEAKIEKAVHWAKAVIFEGVERGRGRVTPALLDSVRVSLPDNPGQCHLNAVASITTKGNALFVEIWDTDATKHVESAIHQANLPGISPQKTGANTLKIPISRPTTEQRAEILRSLSNTVEAAKQQIRIARTDGFKHLGGRKSNGTDEIQKLVDEASKDLDGQMVLAKKEFEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IAI0</accession>
    <name>A0A1B9IAI0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_01714</name>
        <name evidence="4" type="ORF">I206_103280</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="OCF52424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC69342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019153482.1"/>
    </dbReference>
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    <dbReference type="STRING" id="1296096.A0A1B9IAI0"/>
    <dbReference type="GeneID" id="30170083"/>
    <dbReference type="KEGG" id="kpin:30170083"/>
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    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF10">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="590"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
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        <location>
            <begin position="379"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="732"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="894"/>
            <end position="915"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
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            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="810"/>
            <end position="821"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF52424.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC69342.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IAV7</accession>
    <name>A0A1B9IAV7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_00044</name>
        <name evidence="3" type="ORF">I206_101279</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF52748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC67371.1"/>
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    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
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        <location>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC67371.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="134" mass="14905" checksum="81FF6A718ED34C92" modified="2016-11-02" version="1">MFSIKIILAIISSLIIGISGKPIHPTYPEPVFVLRPNNITMDQFKEEFLVLCPKYYGNNEVTDQPIFIFETFQERFEKDIWHGRKAAVQCIYQFPTAGYQNIGVDIARALGGDGLISIDPIEGGPLAGGDADEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IB77</accession>
    <name>A0A1B9IB77_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_00223</name>
        <name evidence="9" type="ORF">I206_101103</name>
    </gene>
    <organism evidence="8">
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        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
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        <property type="protein sequence ID" value="OCF52922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC67196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019152003.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A1B9IB77"/>
    <dbReference type="STRING" id="1296096.A0A1B9IB77"/>
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    <dbReference type="KEGG" id="kpin:30168592"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016652">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19120">
        <property type="entry name" value="AKR_AKR3C2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044494">
        <property type="entry name" value="AKR3C2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="17"/>
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    </feature>
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        <location>
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    </feature>
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        <location>
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        </location>
        <ligand>
            <name>substrate</name>
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        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF52922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC67196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
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</entry>
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    <name>A0A1B9IBQ8_9TREE</name>
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        <submittedName>
            <fullName evidence="5">Nucleolin</fullName>
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    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_00123</name>
        <name evidence="6" type="ORF">I206_101200</name>
    </gene>
    <organism evidence="5">
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        <lineage>
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    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
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    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF52827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC67292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014046.1">
        <property type="nucleotide sequence ID" value="XM_019151908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IBQ8"/>
    <dbReference type="STRING" id="1296096.A0A1B9IBQ8"/>
    <dbReference type="GeneID" id="30168492"/>
    <dbReference type="KEGG" id="kpin:30168492"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
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    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="190"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="290"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="362"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="376"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF52827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC67292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="441" mass="46081" checksum="45CF7EE077F5372F" modified="2016-11-02" version="1">MAKASKSAPPAVAAKDNADKKALKKSKKDGEKVASAPAPVKEEKKSKKSKKAKTPTPPPSSSSESESDSEESSDDSSDEEEAKPAAVAAAPAADKEDSSDSESSDSDSDSDEEEAKPAAKAEEKVAAKEDSDDSSEDDSESSDESSSDEAEAKTEEPKTNGKRKAEDQEEAAAPAPAKKARAEDEEEASTNVFVGQLSWNVDNDWLKSEFEDCGEVVSARVVFDRDSQRSRGFGYVEFSNLESSAKAIEKNGHEVDGRAIRVNYATQRNPQQAVEKRAKAFGDQQSPPAETLFIGSLSFSVSEDQIYEAFGEHGDVQSVRLVTDRETGAPKGFGYVQFGDVESATAALKALNGQSIAGRPIRVDYAPPKKDNNERGGFGGGRGGGRGGRGGFGGDRGGRGGFGGRGGGRGGAGGRGRGGPPRGGARTGGIVKPEGSKVTFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IC14</accession>
    <name>A0A1B9IC14_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_00265</name>
        <name evidence="5" type="ORF">I206_101061</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF52964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014183.1">
        <property type="nucleotide sequence ID" value="XM_019152045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IC14"/>
    <dbReference type="STRING" id="1296096.A0A1B9IC14"/>
    <dbReference type="GeneID" id="30168634"/>
    <dbReference type="KEGG" id="kpin:30168634"/>
    <dbReference type="OrthoDB" id="60843at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF84">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13672">
        <property type="entry name" value="PP2C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="329"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="193"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF52964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC67154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="683" mass="74035" checksum="3207F8045CF134C3" modified="2016-11-02" version="1">MSKPKPGLGKGLVRTFATSVSQYPSHHLQGIITLAPVIGQQHYHSISASSSSHNTLGSPSKNGVNGWPTSSSSTITLLPTWDQPSEIVLPYHSSTSSSSKSRIRLKSSSASSSSSIIGNNQITSRRYSSISISPSAFLTSPIPPPHSLFFDKSLSYQSNVTPPSPAQISLETLLSALEPTSLINEFGFNSRNNSFSDLPPPEPPSSPSPLPSASRSSSPNNPPIKGLRSVESHTVLSPNPLTPDNDSSTNQSTLFSSNSLLSLSDTSNHGTASSLKEDSEDISSSTYSSSLIFHLGCSGLPKERIPLPPSKNIRRTPQPPRARSFPLPIVESPSHLKSIGVGEDAYFARTDGLCIADGVGGWSRSASASKGSADAGRWSRLLTHFVEEEVADWWNGKEYYLISKEKGASKDEKSQYDSSLKKKNQSQGWARESWENKLNRNMSSSALTSSSEKFNRESERRPIDPVEIMQRGFEKCLSCINAEGIHGSSTCLLALLHDSTLHIANLGDCCLLLIRKGEVVFRTQEMQHAFNFPLQVGTHSRDEPMKDAQRYDVSIKKGDVVILGSDGLMDNLFDEEILEIVLQFTSDSITSDQSPTTPSLWNKEPSLPFSPQQVSEALCKKARSISELVTATTPFMCKAIEEGIDFVGGKKDDISVLVGVIGDKEEVGQEGEEKTQGGLQLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9ICP8</accession>
    <name>A0A1B9ICP8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Polysaccharide biosynthesis protein CapD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_00712</name>
        <name evidence="3" type="ORF">I206_100613</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <location>
            <begin position="10"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02719"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF53409.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC66709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="377" mass="41923" checksum="40D6BFA661352BE7" modified="2016-11-02" version="1">MTTQNSGKTVFFTGATGYIGGTVLESILNSPKPPKLITLLIRDEKKSNDFKNLETAKKQNVEIKILISSLDDLEKIEKASSEHDITIHTADADNLKGVKAILKGQKLRKEKTGHRPILIETSGTGVLIDKAKGEYPNDIIYTDLNPTPKTKDFPALISMTEIPESNPHRNVDLEILEADKAGYIKSYIILPSTIWGKGVGEVYDKGLSNSFSDQIPTLIKAGLDRGRAGMVGEGKNIWPHVKITDLGNLYQLIYLKSIETNSKIGHGLSGYYFGISGEYTLFGATSRIGQSLVSNNLIEIKETTPTSFNQEELKKYYNGSTYMGTNSRGVADRSKSIGWKPKFTEQEDLYQHISRETIRVEKENGKQFNNKKFTSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9ICV1</accession>
    <name>A0A1B9ICV1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_00783</name>
        <name evidence="8" type="ORF">I206_100543</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Tremellomycetes</taxon>
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            <taxon>Cryptococcaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014697.1">
        <property type="nucleotide sequence ID" value="XM_019152559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9ICV1"/>
    <dbReference type="STRING" id="1296096.A0A1B9ICV1"/>
    <dbReference type="GeneID" id="30169152"/>
    <dbReference type="KEGG" id="kpin:30169152"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Znf_FYVE"/>
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        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
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        <property type="entry name" value="FYVE"/>
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    </dbReference>
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        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="173"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="244"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="325"/>
            <end position="341"/>
        </location>
    </feature>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF53478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC66640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9ID66</accession>
    <name>A0A1B9ID66_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_00894</name>
        <name evidence="3" type="ORF">I206_100433</name>
    </gene>
    <organism evidence="2">
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        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
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            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="David-Palma M."/>
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                <person name="Mohammad A.W."/>
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                <person name="Litvintseva A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
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                <person name="David-Palma M."/>
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                <person name="Bowers K."/>
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                <person name="Mohammad A.W."/>
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                <person name="Yurkov A.M."/>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
    <sequence length="506" mass="57300" checksum="C7D652447A7B116D" modified="2016-11-02" version="1">MPSPPTSRVSNSDSIFDEEEGMGLKLARLNEEMMIIQDEDGARMSISRNDYEKYYNTINQIDESQHMMKYNKSVSSLSTLHTLTNSFSNIGREVDENETDGDTSSVPDMMSDDEDFISITTDSKSTTPAQELGNDPMEYRIQDLDNFAVPKTTTEDEIQHESERGDLQEAIEEMNACLGPLSHQDIRFTPLDIESIDSLEHPRGTPSWYESASNLDTGGGHGMLVSADETKVVKETHQEEKIFYMRNECNDSVFEGLTAHIPAYYGSFNKFLPIESNSNPCSTSQNSQFPEAAMSKKIFARPGLKRFNTADTHNDSIILENLKYGYKPKTISEFDLKLGRDMIDPYAPDSTPYKIDRMNQQVQSSTSSSHALRLVWANTAIKNLETGEYTQIKTDKTYGKTLNRGLDDNERMNHDDLDDAFIRLFPSPRDTIVPRGKASRFDTSSMPSEYDIPNNAVERYYQKIKDTIATQTNERNITNLLTPRTLTEELTRNEKIGKTQAESRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IDV8</accession>
    <name>A0A1B9IDV8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_00909</name>
        <name evidence="8" type="ORF">I206_100416</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Agaricomycotina</taxon>
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            <taxon>Cryptococcaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="OCF53604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC66513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="RTA1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF1">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628586" evidence="6">
        <location>
            <begin position="23"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="96"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="177"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF53604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC66513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IE44</accession>
    <name>A0A1B9IE44_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
    <gene>
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        <name evidence="3" type="ORF">I206_100111</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Cryptococcaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019015128.1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="695"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="740"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="769"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC66275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="798" mass="90253" checksum="EA1D606E386CCDBC" modified="2024-07-24" version="1">MSQITSMSIKSIVIRIIITVLIILPIEIKAITEYQVLETVKQFADGFISPKNIEIAKSINSKLFSENVIGTADLSTNFDGRELSTEYLFGLFVNTAEDLTDPSPFGSPISYNVTSLLIQNSYISTSIKFLFSYPSLNQNFPIQIDAFLKINENKQIEQYDISFRRWAWATDVIIPKLIPLMAIRPNITASSNDTNGVLRQYMSNKICKTALDHCSGPNEQYKDWNECMDFLNGREIGQWYRMGEDNLVCRHLHVPMLPLRPEIHCPHIGPTGGDMCISRDYDQVVLDSHFPQGWLAPAYVTPENQDEIAGIQATSTEDLNPLIEIALSSSDSHSWDPTLYATALLGYFLFFYFMSNLIWFIYFRKSSVFPTAGLEHQKNIVVYTMNIIFTTISLALELVASPAFAGRFHLWEVQCLRTAGVLTSALYIFELIYRLKMRMPMIAHHFLTIIAISFTVTVFEYTQSMSYLCSAIIWLFQATTEQPTFIGLLGYRLDWEPRTVSRILKIASLQTFIFKSASAIALIAYWGVHQNYSYNSVDRAWTAMVFIIAIGLLLTQIWGSWVTFQIARRIERQPPTLSKANPPLNNSDLAIYQTIRSNLKEKDPHHPHNEVHAHIRTDSMISSSSTIDQSDEQRYRDEQLAPSQRQEGNRSKKRLTILPSFSFLHDDNGQRQISLLTESDYNKVDERIKQGSSISSLSPLLNGHNGKTGNNQIQNSSSMHPSTNESTHSGPDEGGLRLDPTLIPLPKSPSISPISTTMISRNNNDRETGSSPSPNIPLNFNFVCASQERSPREDGNEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L127</accession>
    <name>A0AAJ8L127_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_101344</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058477.1">
        <property type="nucleotide sequence ID" value="XM_070202376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L127"/>
    <dbReference type="GeneID" id="30175057"/>
    <dbReference type="KEGG" id="kpin:30175057"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF56">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="27"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="91"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="251"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="747"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="762"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC67436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="917" mass="102904" checksum="64EF65CF91F6C80D" modified="2024-07-24" version="1">MSPSSTNNAEAGPSNESKKRSKQPQLSCAECRRLKLKCDREVPCSNCIRRKCSELCPDGVKETRKQVFDIKAAESLQKRLLTLESLLADHGVDVPPTSEIDHYPFNNNNKRRRESSRSTTSRPSASPRYRSPSISNIRQPISSHRDYPIHPSLHQRHGSNGSPLPNEPNYWIRPSTDYSSIHPLPPIPIPHMASSPQKSSELIPVDSANQLRTNNMPEPGLPSPVEHSHGTLVIGQEGRSRYLGPTAGTEWLKNQEMGDGHSSGSTESPEPEEQAVPTMSPDRIKRNVPEHLLSFPFPLPNGPSTMESLLSHLPPKDDAEVLMDSYYRYFAWNHDTAPRKFFEPIFDRIFQSISNKSYRSVHPQQLALLFAILAMGTLQNLELPPNDPTANEYLSLAKGCLTKGDFLNNNTIAGVQTLIIMAHYLLETEKGRNGDSAWPLWGLAMRIIVAMGLHRDGARWNLPTDVVEERRQVFWAAYAIEILQANCFSRPTSLALQYIDTAFPIGPSDYPEGSKSYQTKRFELIQLSAKILDTGMSVQFESYDTILSLYTQLCTFERTLPYDLRCRTSMLSLPSEYPDTNFAKEQSPEITRRNLKKTFQQFTLALNISEHVLFLHRPYFVMAMHDQPIDPTRSVYGRSYLAVIERCSVIIQIVSTLYEVHPAVSSRQWFLWYHIFTAAVCLGTMVLRNPTSMLAQFALTSIDQAISVYSLLIKQNNTTSMIQNHDWLTRLRSRVFNKIITVSQSQVGENVDRESNDEGNGERSSATTAGSRSHRDSIHSANTNGEEDLDIVGWKTRLIESASNGTQIAINIPSSTNINPSTRQPEQLQMINPTANGGHDFNSPMNTSGQDISHNGVAPAVQQVLQQHLVGTGDGPNMSGGQFGMDTATDLLLHQFWDPMMLNDSNELASANWWSWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L1S0</accession>
    <name>A0AAJ8L1S0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Senataxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I206_102915</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012419.2">
        <property type="nucleotide sequence ID" value="XM_019155016.2"/>
    </dbReference>
    <dbReference type="GeneID" id="30171635"/>
    <dbReference type="KEGG" id="kpin:30171635"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001147">
        <property type="term" value="F:transcription termination site sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18042">
        <property type="entry name" value="DEXXQc_SETX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000326">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001152">
        <property type="entry name" value="tRNA-splicing endonuclease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024481">
        <property type="entry name" value="Helicase_Sen1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056474">
        <property type="entry name" value="SEN1_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF495">
        <property type="entry name" value="HELICASE SENATAXIN ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23576">
        <property type="entry name" value="SEN1_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12726">
        <property type="entry name" value="SEN1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase Sen1 N-terminal" evidence="10">
        <location>
            <begin position="90"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase SEN1 beta-barrel" evidence="13">
        <location>
            <begin position="1300"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="11">
        <location>
            <begin position="1439"/>
            <end position="1713"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="12">
        <location>
            <begin position="1721"/>
            <end position="1916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1010"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1063"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1150"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1946"/>
            <end position="1988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2009"/>
            <end position="2134"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1570"/>
            <end position="1607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1975"/>
            <end position="1988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="2063"/>
            <end position="2075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="2080"/>
            <end position="2091"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WWC68979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2134" mass="236092" checksum="1E4C610E86811CEA" modified="2024-07-24" version="1">MSDDPILAKEVGAVLKSRASSQEKPSDSDLLPVYRYLVPSSTASSSSSTSKVDKETHWYCKKAKSALHKESATYLIFLFAFQRQGTSKAWVDRLEEVLLSCEGCARAFGGARRKLGSKYLSKWPSQVRVNFFAAVDKWQSTLILNQIKEASKTAYGTTSFSSTPELYTLTRPMLQLLLSEPSLIDPEKGLNSAELSSSLDKAIASSAVTSAITSSGVSTLLVHLLSSPIEVRRKWAISQLASSSRRSLPFDEWCSLGIGQEIQSLYSDDVQIDGKDRWVAVSAILTAGVLNTETVEKGLLGGQLEEDPKGRKNRGLMSALSALLGSDVPYFPEVLSCFSTLLNICPNQHIWSFDTSPDRPHTLFSEIRSNPAFQYLIETRYQDSPADMNAILPEWSEKLDKGKGKSSESSESLDWIRNFLVSLVDLEKGDIVITDGKKTSGFSEALALAMNFTFQEMQHTRLAGSLRAAAATAGFESLIAVHQAISSEDVTMVITLNSTLDLHAHFITTVALRHKDYPLPIWSQARSRASDLLVTFFSADGESTVQSVLAMATMSHAEKKRLQRKKRNKGDVAAAVRVERLPHACINKELWNMAYEALSPSDVVGAAIIIRSMAPFSHLEVIDRQNSWKYEGLEEVVKKEEWVDTIRSVNSTIKGSREAFPRAIESLAMGLDPEYVKSLWNQPGVPKAVTMLLLSPDDEVHTPIITLIQQTYEDVDDRADCFRALLQNHPDMTMDGLTEFLRTFIQTATYTPESCSLAKWLVRCFHDVLEALCTGSASSEALLQTTQFLTSFADGKGMAKRIEELWHLMTTSLALIFKRTLDWAPLFENEVMVDWMRDALIFGRQMTDHIRAFEGAVLGQSGNRSFEDVLESPVKVTSVGKKMARQLEMVLTDLILWLRLTDVETLFQTHQLIKTILDRISRSVPDLSKNPVLERTLQEIDKFCRKSSKSYTSRLTDDRLSELSELLIGFNLTDQDEIQFVKQVSGTSTHEPERIKSKPTVRNAFEEMMKASGKTPPAKEKAKPSGPPPKVIDVDDFDDDFLDNLSSTDLDIIEKRAKITAKDGKPTTAVKPRLPGQLSTSARPQIPSNKIHVDLTHRAVPKTTSAFTSKFMREMKSQHNQERKREIGGIVPKLPAPSALGSGLGVYTGPRAKTVQPVDSGSSASESSDDEKGAMSNLVAKQKPLPQIKPVEKRSIKIIGSDTSDMLRRNEEKRAKAHATKMRLKPDLNPLYRYVLSWNPDHKGSTAPHGEKYAPTLSNMRNVPTAFGSALQYEQVMLPLYLQELWSQCIKEDNVSMKGTVQVEVSSRQYEDDFIEIDLTVAGPAGDFFANETDVVILRQPGNSNAIFAKVQAYKRKPKEIAIKVRIMASMDQRELSGRSKWQLKKHLSLSTAIREFAALKGLPYYESALLQDALAGRSAPMPGLALDDIEDAMKSYDVNEPQAKAILGATHVKGFALIQGPPGTGKTKTISGLVGKWMSERRTPMSVDGRPPPKPKLLVCAPSNAAIDEVCKRLILGVPSSSGIRLSPTIVRIGIDSSVNIAVKDVSLDSLVEARVNAETNGKDGGSEYARLQSELDSVKQQIKDKQEQLRLVQNHEEKRKVVENDYHALVTRRTQLGQAASRAKDAARDATRHLDGARRAAKEQILNEADIICATLSGAGQDTLAAHIFETVIIDEAAQAIEMSCLIPLKYGCKRCIMVGDPNQLPPTTFSVEADRYHYNESLFVRMTKNKASQVSLLSIQYRMHPFISELPSKVFYNGQLKDGPDMARKTTAVWHQRNVFGPYRFFNVNGHEEKAGTSTKNTAEALAAVDLYKRLNMDYGMKINLSMRIGVISMYKEQLWELRRRFTEAFGGTILETIDFNTVDGFQGQEKDIIILSCVRSGPNLRTIGFLKDARRMNVALTRAKSSLFVFGNGPTLERSDERWKTIVGDARERGFLIDYTSSTFGPEALDPPPPKKKKKERLSNGDSKSHSIAAPASPDSLLPPKALAAEINTIKRKASVDAIGDEKKRIVPNGPGPDADYKNFSPIDPKSTKPIAVPVPKTNGVANGDHDNQIVPRPRTTTTEASINPQSRPHAPKGPAPPPPPPQRTAEDALFIKKKKKPNRPGNTGPSSAPAPNVRAAMNQRFGARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L1Z9</accession>
    <name>A0AAJ8L1Z9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_103020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058770.1">
        <property type="nucleotide sequence ID" value="XM_070202669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L1Z9"/>
    <dbReference type="GeneID" id="30170344"/>
    <dbReference type="KEGG" id="kpin:30170344"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC69084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="424" mass="46966" checksum="2C00126D00DA65EB" modified="2024-07-24" version="1">MEDHPLVQLHPIVIQLATVPAVAIASYKALNVWRAVSSLPLNPHTSGSDASERSATSEAFRQWRALTATKKAKKIAVFLLFFSLGLSFHLFMVFGLSKISSQSVMDIIWCIILIAMYAGPISYVSDLVFPTPRSVRYHRAKTGAPMRMIIEFEGDTKKALKIEIARLLLSLIVVGGMIYSTWAGYTYLHSILGASYIITVVASIRYPKMSIRRIIQVISGYLIIAPPLSIALGLFITYITGGSKTDEDPAEPRKEESLTIMSDWVLSLIFVFSDIFGAIVPGIITAMTLRFEYSLINEPVHRPSEASTDAPVRIPNEYPSFPKPIFISSLLSLLASLGFLNIVTFVFPDIVWLGITPLNIYITVPTVFGSTACAAAYFGKFGQWWRYNEVWIPQNKVLDTSEEGAKDLDDEEAALLPTEVKETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L255</accession>
    <name>A0AAJ8L255_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA mismatch repair protein MSH3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 14">DNA mismatch repair protein MSH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">MutS protein homolog 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">I206_102599</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer consisting of MSH2-MSH3 (MutS beta). Forms a ternary complex with MutL alpha (MLH1-PMS1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058694.1">
        <property type="nucleotide sequence ID" value="XM_070202593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L255"/>
    <dbReference type="GeneID" id="30171322"/>
    <dbReference type="KEGG" id="kpin:30171322"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000004">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000004">
        <property type="entry name" value="DNA mismatch repair protein Msh3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003810">
        <property type="entry name" value="PRK05399.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF122">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="17">
        <location>
            <begin position="1036"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="175"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="58"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00025902"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00029792"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00073774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="WWC68667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1204" mass="132866" checksum="587D492165854A17" modified="2024-07-24" version="1">MTPKIPDGRAQASLHSFFKRKTPPLSSPTKQADHQDPVIDLTGSPPLKKSKILTSPKSIPSNGSLGPSSSSYFSKPARTTSSNTTPAPPSTNASTSATLETYRLPKTRIQPSSQSGSAFDVYSVSSEAGPSTSSQTRTEEQQRKHEAWQNRLMNGGLIRRRRSLRLDEAAAAELRRQNGIETPENESGMDTPTIEEPEGIDSDDEDRRKAAEGVGSRLAAKYASKVTDGSKTTKGKGKKKEEVGPSGQTYTPLEKQFMEVKAKNQDVLLLMEVGYKYKFHGEDAKIAGRELGIVSRNFYTASIPTHRLHIHVKKLISLGYKVGVISQTETAALKKAGENRNAPFTRELTHLFTAATYVEDPSLPSSSTALDDPVVPGTTPPPTNALVSIVEQGMGGIANDDRARISIVSVVPGTGEVVWDEFDDSQVRSELETRLTHLQPAELLLPKAGLSKATEKVLAHYAGGPGVGSANPVRTERITKLLEYNDAFDYLTQFYDGKVQSKKNIELKRKHNDRIDLTLSDNEEDTVNTNGHTGVETNGRDLSGMEKEGLSLVDGLDSAEAILALVDFPKQVVVAFTIAVQYMKTFGLQNAFKHRSTFAKFINRAHMLLSSNTLVNLEIYRNQADGGIYGSLLWLLDHCKTRMGRRLLREWIGRPLLDIVALRARTDAIEEIMESNTYYMEKLRSLLVNMPDLVRGLTRIQYGKAQPTELATILVALVRIGSEFKPSNDPIFKSTLLNNILQTLPKIQSIAKGFLESVNLKAARENDEGHLWTDPEKYPEIQDAKDCISICESELDQHLKEIRKLVKRPTMNYVTVAGIEYLVEVPVRDAKSVPPKWVKISATKSVNRYHTPEVLRINKEREQHKETLNAVSRAAFKSFQSDISDHHELVVVSKQIAVIDCLMSLAQVAAASGYCKPRFVQEPELRIRAGRHPMVEMLRDEAYVPFDIDFSEKDGTSKVITGPNMAGKSSCVRAVALIVCMAQIGSFVPASSVTLGVHDAVQTRMGASDEIGRGKSTFMVELSETSDILRTITPRTLVILDELGRGTSTYDGVAIAYATLSHVAGTGCKTLFVTHYPMVAEQLAREKPSQISNWHMAFDEIKLGDGSAEITFLYKLTKGLAEASFGIWCARLAGLPKTILANAQTRSNYLKHETKQRLLSSLGKRTRNLLSDIRANSEQNNSIDVLKDVRILDRALSMLDNNHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L2K1</accession>
    <name>A0AAJ8L2K1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Steroid 5-alpha reductase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_102813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012320.2">
        <property type="nucleotide sequence ID" value="XM_019154917.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L2K1"/>
    <dbReference type="GeneID" id="30171536"/>
    <dbReference type="KEGG" id="kpin:30171536"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF17">
        <property type="entry name" value="STEROID 5-ALPHA REDUCTASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC68877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="32685" checksum="7B941E6480677AFA" modified="2024-07-24" version="1">MVFLGLHPAVTSRLAGVLGFTFAYQTAFALYSVPNKTEKFYDLAGSTGFITSTLLSLYYPTVKSWVTKSPTIPFTLSGHHPRQLLVSAMMLIWAGRLGYYLFGRIAKHGSDSRFDDLKTKPAIFSGMWFGQALWITLVGLPAYLVNSVPAAAHPALGIKDFIGLGIWLAGLGFEVLADSEKSQWRKEKDEKKHEEKFISSGLWSLSRHPNYLGEVILQNGPPLLAFTTPLPPTVKYLCFVSPIFSYFLLRYASGVPPLEESAEKRFGDDAAWKKYRDETSMFVPLPFGLGKGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L321</accession>
    <name>A0AAJ8L321_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_103222</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058799.1">
        <property type="nucleotide sequence ID" value="XM_070202698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L321"/>
    <dbReference type="GeneID" id="30170142"/>
    <dbReference type="KEGG" id="kpin:30170142"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09252">
        <property type="entry name" value="AP-3_Mu3_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14837">
        <property type="entry name" value="AP3_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="6">
        <location>
            <begin position="191"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC69284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="451" mass="49971" checksum="8C0AFC212A56C4A9" modified="2024-07-24" version="1">MARIDGIIILDSNGKPLISSHFALHPPSYPSLHIDSFNTARKKAIADDEELEPVIWVNTLARGGSSMSGAALCHIQREGMYFLVPVGQEVNPLFAFSFLDSFLDTLKDYLGDITETSIKDNFDIIYMLIEEMLDEGHPMTMETNMLKEIVLPPTLMRKLLNVAGVSGLQTPTTQPFTAPIPWRRPGVRHSTNEIYFDIEESLDAIIDKRGNLLSSAVRGRINCNSRLSGNPDLLLNFANPKVLDECAFHPCIRYNKWEKNRILSFIPPDGKFILLEYQAVASTSKTQIPLGVKANLVVEPNGGRFSLTLTSRLSSRPLEDIVISIYLGRGATSVSATAQGDRKPIGIRSDEGVADGHVGGGNWEFDPHTQIMKWNLASLVTSERSPTLTGSFASSETQPTPSPSFDVSFNVQHHSFSNLRVDQLKVTGDVMYKPFKGVRQIARSGKIEVRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L353</accession>
    <name>A0AAJ8L353_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Anaphase-promoting complex subunit 4 WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_102213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058630.1">
        <property type="nucleotide sequence ID" value="XM_070202529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L353"/>
    <dbReference type="GeneID" id="30175950"/>
    <dbReference type="KEGG" id="kpin:30175950"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990811">
        <property type="term" value="C:MWP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990810">
        <property type="term" value="P:microtubule anchoring at mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052778">
        <property type="entry name" value="Centrosome-WD_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16220">
        <property type="entry name" value="WD REPEAT PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16220:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN WRAP73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WWC68290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="548" mass="60547" checksum="5D917C954AE728BA" modified="2024-07-24" version="1">MSDGYDFSPSYHASLVSYSPGTTFLATVYQNRVIIRSTSTLQIVRTWSCNQPSSIASTSRDIQEQVKIDSVEWSEDGLYILAFSSSIKTAWVFALATNGDGDSGEIAKIGGEGVEGLIKVEWGRSGKTILAWSDFNLKLSIFDLSSGITRIIQNPKSHLQCHTYSSDNRYMAIVEKHLGKEFIGIYDVLDNHHLVRHFQLSTSDVQGMSWSPDGKYLAVWDSALSYSIYIYSPIGPLLSHFTHTSLTFSPESLSEDPGLGIRTVTWAPGGRWLAIGGWDGKVRILESTGWRCIALLNNPSRITEKDVTVWKEPQDWVKDTRGHGIVQFDRMQCPAAIPNSRPDLSKVNPNMGISQISFDKDGALFAVCSESTPNALHIYTFLKSPTAEGPEISHLTTLLFANLVKTVMWCPGTKGRKLAVTAKSQALYLWDEEGNWEEENTKETGQLSVGIEKGGVMEGICIPSRSNFSAVDLQWAPDGSSLVLQDKSQFCLLYDNDSDTNQVTLDRSGMWTPAGEGLSHVMEEEEYEDGWSGYGLNLRQGFSSGIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L3L0</accession>
    <name>A0AAJ8L3L0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_102444</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011956.2">
        <property type="nucleotide sequence ID" value="XM_019154553.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L3L0"/>
    <dbReference type="GeneID" id="30171162"/>
    <dbReference type="KEGG" id="kpin:30171162"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050973">
        <property type="entry name" value="H3K9_Histone-Lys_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007728">
        <property type="entry name" value="Pre-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223:SF3">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SET-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SUV39H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50867">
        <property type="entry name" value="PRE_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SET" evidence="9">
        <location>
            <begin position="6"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-SET" evidence="10">
        <location>
            <begin position="62"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="11">
        <location>
            <begin position="301"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC68515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="35581" checksum="3EDDD9C4CFFC879B" modified="2024-07-24" version="1">MEDISKGLEPFRIPIEDTHHLGSFLLYITDSIFPDGTPVTTYEPESSSADGESDEDSTNETYTCSCVANHDDHPSVNICTVENGATCDCVSDFGNFYYMPSGNCDDHKDIDRQLLNLEALPERLPLVECSPICPCSGNCANRLTQRGVLISTTIRPSSSGVGLGLFYISTTHDDLPQGCFVSLYAGEYLTTDQARQRWSNQRVHEEGQGNHILSLKLPGKTWHIDPRFKGNIGRFLNHSCDPNCVIQIVRWGIDSLPRAAIFTKRGVRVGEELTFDYANASGSVDLAAQLDRQNVIEDGAGRTKCLCGSQKCRGWMPFDETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L433</accession>
    <name>A0AAJ8L433_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_103114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013808.2">
        <property type="nucleotide sequence ID" value="XM_019153647.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L433"/>
    <dbReference type="GeneID" id="30170251"/>
    <dbReference type="KEGG" id="kpin:30170251"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC69178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="116" mass="12743" checksum="93D892ABA08F1C47" modified="2024-07-24" version="1">MRRTLGYSPNVPTILTSQNCVWLQLKTSISMASYHMTSDDNGEPPYVDCFSKEELDASGETTNTTGNPGRMSNYHMTSDGNGEPPYVDCFSKGELDGESRPIISIGKTTNTRLNPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L467</accession>
    <name>A0AAJ8L467_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_102530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058679.1">
        <property type="nucleotide sequence ID" value="XM_070202578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L467"/>
    <dbReference type="GeneID" id="30171250"/>
    <dbReference type="KEGG" id="kpin:30171250"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057678">
        <property type="entry name" value="DUF7918"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25534">
        <property type="entry name" value="DUF7918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7918" evidence="2">
        <location>
            <begin position="19"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC68600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="300" mass="34446" checksum="7894132E776375A2" modified="2024-07-24" version="1">MLAQNHAAGFEAWVEGLDDQKRLNEYQIEHHPATEDKSSYTECFLETIDEPFKIMVNKPVKHNRNTEFRSTTKVDGHVLESFVWLKGYLTLWWDEVLEQEGGKTYTSKLKFAPTLTTDDPNQVTIDKAALSTLGTIEIILEKGKFAPSRMGNAQTTKIQAGVAHEESKKFSYSVTTTDRKPYEPQESMHYSFKAEHVGKIFHRFIFKVLVHMRIIDEPESSPTPPPPPRKRKRYSEVIEIDTDEEAVDIKGEEDVKPNLTAKRMKYLEEQIKLLSGQLKQKSKDKDADNGIVDLTKDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L512</accession>
    <name>A0AAJ8L512_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidylinositol 3-kinase VPS34</fullName>
            <ecNumber evidence="7">2.7.1.137</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_103401</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12709"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.137"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:12710"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.137" evidence="7"/>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058857.1">
        <property type="nucleotide sequence ID" value="XM_070202756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L512"/>
    <dbReference type="GeneID" id="30169964"/>
    <dbReference type="KEGG" id="kpin:30169964"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08397">
        <property type="entry name" value="C2_PI3K_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00896">
        <property type="entry name" value="PI3Kc_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.70:FF:000009">
        <property type="entry name" value="Phosphatidylinositol 3-kinase VPS34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057756">
        <property type="entry name" value="PI3-kinase_type3/VPS34_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002420">
        <property type="entry name" value="PI3K-type_C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008290">
        <property type="entry name" value="PI3K_Vps34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF7">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00792">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000587">
        <property type="entry name" value="PI3K_Vps34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00142">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51547">
        <property type="entry name" value="C2_PI3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="C2 PI3K-type" evidence="11">
        <location>
            <begin position="19"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="PIK helical" evidence="10">
        <location>
            <begin position="303"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="9">
        <location>
            <begin position="581"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC69461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="879" mass="99519" checksum="C94B1E70298ACEB0" modified="2024-07-24" version="1">MQVDSSRDKDYSFARLCDLKSHVTLKITSLEGNIPRRSYTDSLKDSDLLHAGLQHDGPSDLYITCQLWANGIQYTLPFRTSWKDFPRGYTWNQTIILPITYPSLLINSQLAFTIWDCHGAGKPVPVGGTTMSLFTTKRTLKRGQQRLYVHRGVEADAKANTSTPSELIGEPEDEMGRLERLVKDFDRGDIVKIDWLDRIAFRQIEKAHAAESSKSDKLYLYVDLPKFDFPVVYSEQESSIPLPPAPMPHPAPQTQQQLSGVPPHLLSSDPYLWRTYDPDAWRENPVEIKHRKLLRSQRLGDEGRDLKPGPAERDRLNEIFRLPPTASLSALDKDLLWKFRFSLFRSPRSLTKFLKCVTWTDPVEAKQAVEKLLPLWGQEVGMDDALELLGPGFTDKRVRAFAVKRLERADDEELLLYLLQLVQALKFDLMTSMAESMRGTRHRKRDATAKSDEGDSGLSKFLIDRSTANPVLGTSFHWYLMIECDASQPAGKMYAKVAFTFQTRLSETPEGIAQRDILKRQGQLVEALSARSKEIRSSKDSRSKKIEKLKTFLGDPKHNLSPLPLALPLPLNARVSVTSVTADKSSVFKSNLLPLLIWFETTDFTRQTDDESPETPISITPDYPIIFKNGDDLRQDQLVIQLFTLMDRLLRKENLDLKLSPYSVLATSKVEGMVQFVPSKSLAAIMAEFGSLQNYLRQEHADDGALGSYGIETGVMDTFVRSCAGYSVLTYVLGVGDRHLDNLMLAPDGHFFHVDFGYILGRDPKPYPPPVKVCKEMVDAMGGTQSAHYARFQSLCYTAFIGLRKNANLILNLVALMVDAGIQDIQSEPDKAVWKVQEKFMLDLSEEDAIKQFEALLNDTSYLTMMFDRIHDLAQYLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L517</accession>
    <name>A0AAJ8L517_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Vacuolar protein sorting-associated protein 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_104147</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the VPS29 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010973.2">
        <property type="nucleotide sequence ID" value="XM_019156015.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L517"/>
    <dbReference type="GeneID" id="30172647"/>
    <dbReference type="KEGG" id="kpin:30172647"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07394">
        <property type="entry name" value="MPP_Vps29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000024">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028661">
        <property type="entry name" value="Vps29"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN VPS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="7">
        <location>
            <begin position="4"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC70197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="205" mass="22350" checksum="078418C2D1CBEDF1" modified="2024-07-24" version="1">MVLVLVIGDLHIPTLTHDLPAKFKKLLVPGKIGQIICTGNVCDKETYDYLRTIAPEVHAVRGEFDENTHFPLSLTIPHQSLRVGVVHGQQIVPAGDADMLAALARQMDVDVLISGGTHRFEAFEFEGRFFVNPGSATGAWSGLWNGDATPSFALMDVQGPVIVTYVYQLVDGEVKVDKVEYRRPDPPKDSIETAGAGRTEVPAGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L518</accession>
    <name>A0AAJ8L518_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_103179</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013745.2">
        <property type="nucleotide sequence ID" value="XM_019153584.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L518"/>
    <dbReference type="GeneID" id="30170186"/>
    <dbReference type="KEGG" id="kpin:30170186"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="3">
        <location>
            <begin position="315"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="227"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="435"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="347"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="454"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="469"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC69242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="592" mass="63674" checksum="DA4E95B983D9BCB3" modified="2024-07-24" version="1">MGKDTDPTMGGLDALVAAASSVAGQGKNRANRANRAANMNSVIDPALQDTATSDVADAMSVFLSNPAVVQLIAEYNAKKQHRHVSLYTQLLSGSVAPSNITPDTPVQQTRSGRISRPPVYPPVPNPFQQFLHNQSSTNHQVTVPPISTDQTQLQAIKDALENVTSANQNTHGLVDGTSMADAASYDELLQAVNNDSSSSTNSRFWRNDNLLNGLPAWTGIEATTLAHAAESPSDPTTSSAYGQRSLGHGLPNGKSFNAGDRKRSASVLDDTGDESLDSPISKRYNGAGSVDNAEGLPEWPLPPTGKGGRKNMPREELLARRRARNRVAAQESRKKKKEFFGGIAEQLKERDDAYDQLHAHCRKLEQEVEALKRVILVAGLEMPNDIPTPIDTLPGPTPGPSVFPNIPNDEETSFNVDSITSGLDLPFHDLFTIDDNDADDLDFVPPSSPKREDSDSDDSDDDEEPTPLSASAKAGSGSASNGKKSKRKVTENEVEQGVGETPTNGTGAEAEDEEENLFLPIEDVPIPPRDEEDQEQVMKQAMNELHVDTPQQLMGVIKKMVETAGYGGVTEEQVGMLSKLLALGQAQGMSIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L589</accession>
    <name>A0AAJ8L589_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear pore complex protein Nup85</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_103270</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the nucleoporin Nup85 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058813.1">
        <property type="nucleotide sequence ID" value="XM_070202712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L589"/>
    <dbReference type="GeneID" id="30170093"/>
    <dbReference type="KEGG" id="kpin:30170093"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011502">
        <property type="entry name" value="Nucleoporin_Nup85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373">
        <property type="entry name" value="FROUNT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373:SF21">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07575">
        <property type="entry name" value="Nucleopor_Nup85"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7 9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="570"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="570"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC69332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="867" mass="97239" checksum="678D7FCB3677BB8F" modified="2024-07-24" version="1">MAPAPTPSGFSFSSSGSSPFSFSPQDKISKQPQSGPSTFSFSNSSNTVQPDASTSASKGTQQLPYNMEYSSHFEDDIEILHSRPYAYKKSEKKKWQSTGRTLCTVSSPVGGELATWVTKKPSSNPNESSTISEPMRSVSDKTIYFTALNWLPQPLIQLYTESHLLFTSLQQIVAESHSRRLPSVGLDKVAEAWDKRGNLVGIEGLLGPPDAETIMHMRRLADLYLDQLGDLKNNHEIDIELRTRFLTSYNILHLAEVLYLPVDGKGEGLVGEEILDWVNDVDPAPDNSQGNEIMSTRNPWDHPSFFPYISRCILRGFQLPAASFLRSLSNHQHSPISKLASLLAQHISVFPRSTEERWRVDLDFLQAHKSWLAKFRAEIVNFTGGKSKGKWFGDDDKYQSMESDIRTIIELMEGRPTRILEEASDWKEALGAWGILVDVDLRRDHLPEIMSMILDKIPVDSTIPEDSIQSALCSADIIKALMGCYDLDIWLSAHLGDLLDQLELIPDDEQRFEIPLRDYFLLEYTEALQNQPKYSAFWRVICDYLNYAGVEGRNRLRSHILRISIGLDGESKGKKRQDNDDQHEGMDIEESDGDRDTNGEGQSKEIEEAVRLLDEVRAACGEFHLEEEFKLISQILAGKLIRKGEYGMAASMSMMASDGWALSRIAEKILDSYITEGDEEFLRLVDTLPPTLLSEAPTALAELQAQIDPVSGLPGLPATSAPSVFASRLTFLSEFRDYLLFLNQGARDRAASKLVSLLTSGIAPISIWAVLLVESIDLLEDSEILFSSNETFELLRVLEEVKSNASFAPSDYLDQLTQYLRRSFTADEMPDSKKVGYEEGWKKIDQVRLALARNLARSLVNGFDSPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L5X3</accession>
    <name>A0AAJ8L5X3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">DNA repair protein Rad5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I206_104118</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059004.1">
        <property type="nucleotide sequence ID" value="XM_070202903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L5X3"/>
    <dbReference type="GeneID" id="30172675"/>
    <dbReference type="KEGG" id="kpin:30172675"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014905">
        <property type="entry name" value="HIRAN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF17">
        <property type="entry name" value="HELICASE-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08797">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00910">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="311"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="663"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="743"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="169"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="WWC70170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="921" mass="102016" checksum="2AC346588B6C02E9" modified="2024-07-24" version="1">MENLMTQGSSSGRSSQAGPSSRPMNVTPTRTKRPREMSTVIKDEVDDRSPSPELDEHFVTFRTDVVGVQYYRGLVGRGEYVMLRREPGNQYDPNAVQVINASGTQVGHIPRAVAGRLAELMDHSLISVEGRMIGQNLDGAKHYKLGMDLSIYARPSLKEVLQTELSWTKTETQVQKPPPSASQPVSASGFRGHGNSGTALPGADDPTMKKLLEGLKQIGEDQRSADNVMDSLTGDIDVSKLPLHPNPPGVASGQLNTDLLPHQSQALKWMIERENPKLPSSPKDKPVQFWVKQKGDHKDYFLNVATKTPQYDEPVLGRGGIIADGMGLGKTLSILSLIMATKKDKVDGNFGKTTLIVCPLSVLSNWEKQIGDHVTHNQMTFYTYHGSSKGVTAKTLEQYDVIITTYNAVAAEAPLDPSNNGRSPQKVKKAKVAPTTAGPLFKVKWKRVVADEGHVLRNPKAKMTQGFAALQANRRWVCTGTPIVNSPSDLGSLLTCLQICKPLDKSEYFKTLLLRPLRRGDPTAGKLLQALVGEVLLRRTKDSKDSKGRKLIELPKIEYFRVGVKLDEETRKGYDEILEGSRQRFREALETGQGTANVLSMLTRMRQLCLSSQLVPQSFLDDLRRPIPKIPTGPAISISSLTAGKREELIAKLRTYVEEDTECGVCYDEAEFAKRPCITDCGHAFCYPCIERILLTAPLCPMDRHPIGLPSILELPPDQIVDDYVDPSDSSQAKSLLPVKSAKIDELVKYLKVFPSDEKTLVFSQFTSFLDQVAISLTGEGIAWTRFDGRMNAAKRQQVISEFQRPLTEKNSKVPRVMLISLKSGAVGLNLTAASNVFLCDPWWQSAIEAQAIDRVHRMGQRKEVRVFQLIAEDTVESAVLDIQKRKDALVAKAFEKSSKESKMTKKEARFEEMKELLGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L7U1</accession>
    <name>A0AAJ8L7U1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_105746</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC71787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059282.1">
        <property type="nucleotide sequence ID" value="XM_070203181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L7U1"/>
    <dbReference type="GeneID" id="30172935"/>
    <dbReference type="KEGG" id="kpin:30172935"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="291"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC71787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="606" mass="67548" checksum="3BAD7881F656980B" modified="2024-07-24" version="1">MVHENGRLVDKSKDIASRRDGPCKARKCRCDAHLPETPSSSVAARHCSQCRNLKIACTFTYQGKRRGPVPGYLRSRRAQLAAKASESDTSPTSSSTYAPIPPTPSYPTYASVTQPKSSASVSTLSSYHDHDPPTSLTFPPSATISNPPNSIFPLLNVEPAASTSNHKSLDAVLPRALRLEILSLFYRCVYPLMPVPHKTTFMADIHSRREELAGQGEWIAMVFSILAFTLVQMPHHLVSITKNEIRELVEKLSHKVKLCLLEDHHTISLERMITVYCIGTVHNNLGRHMQSRALHGSNVVHCLQLGLNEESTYASMDPITAESYRRLFWAIYCSDRSAACSENGNLLFNEDEINVAFPKDLDDQFITRSAFHEPPIGHASIMRGFTESCRLFSMGGNMLSKRMHDRSRPPSGYALRGRINELDDILQGIESLLLEGGFADAVPDMLRDLITTSHADSTPFLVHSAHVRVTQQLFRFLTLQYREDLSQILYHEQLRHVPIRPVLPQSQPRSEEHNKRKVLEDLLQILHGIPLEIHAINSFPGISKIRSVSASLLTSLSAPPGSEPNSASAQDDRSMELLCDFLRLMATIERMYSLVAEPSTASTDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L9P0</accession>
    <name>A0AAJ8L9P0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I206_105653</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingosine N-acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011347.2">
        <property type="nucleotide sequence ID" value="XM_019155193.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L9P0"/>
    <dbReference type="GeneID" id="30171814"/>
    <dbReference type="KEGG" id="kpin:30171814"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF11">
        <property type="entry name" value="CERAMIDE SYNTHASE LAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005225">
        <property type="entry name" value="LAG1_LAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="12">
        <location>
            <begin position="172"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC71695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="419" mass="49895" checksum="678C932D8B577B26" modified="2024-07-24" version="1">MSSSTTQRMPNRGRSSSVTNALKQIPLNQQQEQSYGKVSEVKPLSGKPRPKKRKASKDDLPDNYISRGFWDDLKTGRWMLIPSSAFLIMLISPILYWNHKLLTQYGILKPDTPNPFKYLLWISGELPNGTYTKSIYDFAFLAQHVVFWSFVRQFVTIHILRPMALSLGIKGSKIMRFLEQGYAVFYFTIMGTLGIFVMRGLPTWWYKTEYFWIDYPHKQMTWELKTYYLMQAAYWIQQTILLAAKIEKPRKDFKELVAHHIVTLWLIGWSYNVYLTYIGVSIFVTMDVSDIFLALAKCVNYVSEWASPPFFAFFVGVWTYFRHYLNIWILWSVYAQWNLIPEKERSRFAPLEDQWLVWWMKWQVFVPIFLLQLINLFWYFLIWRILIKAVFYNDLRDERSDDEDEPEGDQTTTEKLKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L9Y7</accession>
    <name>A0AAJ8L9Y7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_105468</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059228.1">
        <property type="nucleotide sequence ID" value="XM_070203127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L9Y7"/>
    <dbReference type="GeneID" id="30171997"/>
    <dbReference type="KEGG" id="kpin:30171997"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060237">
        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051025">
        <property type="entry name" value="RhoGAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228:SF25">
        <property type="entry name" value="F-BAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228">
        <property type="entry name" value="SPERMATHECAL PHYSIOLOGY VARIANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="108"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC71510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="170" mass="18815" checksum="C93CBDF0695D90AE" modified="2024-07-24" version="1">MVSARPPPNPARGRVPYPSAATYVPGDTDNSPTYLGVTSEPIQKTTSRDSERERRVQGLKNWWKGFREHEKLERAEFSRGNKRGVFGEPLSESIEYASVQVSTSGPDGSLYVWGVIPVVVAKCGLYLKENATGIEGTFRVSGSAKRMRDLQTVFDTPPKIGKLYHTPPTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LDU1</accession>
    <name>A0AAJ8LDU1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_107759</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009442.2">
        <property type="nucleotide sequence ID" value="XM_019157802.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LDU1"/>
    <dbReference type="GeneID" id="30174460"/>
    <dbReference type="KEGG" id="kpin:30174460"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
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    </dbReference>
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        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="112"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC73787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="535" mass="59144" checksum="17BCB74616C8AA09" modified="2024-07-24" version="1">MFDTIDSISGFIRPWLTWLSALTLGQVWQFVYNPPNKINLTIALIAITLKLPSYLKRYDVWRQSRKVIDFHWPVPKEADKDWKGTIIHNPSLCAHQSDNSLLPPESGKTGEERDHITCYDPSTGYHLLTLPLLSAAEVSDQIAKANSAQPRWAQTTFAQRISFLRSLKAWVLKDMESIVRVACRDTGKTEVDAVFGEILTTLSKLDWLIKHGEKTISPTSRPGNLLLAHKGSKVHYSPLGTVLALVSWNYSFHNLISPILAALFAGNTIVVKCSEQVAWSSLWFIGGIKACLRACGLNDDVVQLVICLPDVAETVTRNKLIKHITFIGSEPVGKKVAVAAAEIMVPTCIELGGKDPAFILPGTDLDFFASTWMRGAFQSAGQNCIGIELFLVHRSQYSRFIEIMEPRVKSLRPGTDVGSLISHAPISKLQSTLASAEKGGARVLAGGKRYMHPEYPQAAYFEPTLVVDVTMDMEIAQEELFAPVMTVVPYDNVAEAIEWLNKSRYGLGAGVYGKDKGECKRVAEKLECGMVAINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LER8</accession>
    <name>A0AAJ8LER8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_107852</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009534.2">
        <property type="nucleotide sequence ID" value="XM_019157894.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LER8"/>
    <dbReference type="GeneID" id="30174552"/>
    <dbReference type="KEGG" id="kpin:30174552"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706:SF2">
        <property type="entry name" value="RFEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706">
        <property type="entry name" value="SLR1338 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="288"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
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        <location>
            <begin position="157"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC73880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="512" mass="54375" checksum="009A27CF40843756" modified="2024-07-24" version="1">MGFASKITQANQLAGAAGLMSNKPPGASYGAQGGYGVAQSQGQSYGSSQTQSAYASPYGAPPQGQNPYGQQQQPGQYGGQQQGGQYGQQSGQYGQTPSSQYGQTPGQYGQQPGVQGQGQYGQQQGGYGAQQGYGAPPVPGGRPGQPAYGAQTSGQSPYGQQQPGQYGQQQPGQYGQQPGQYGQQQPGQYGQQPGAPGAYGQQQQYGAQGGYGQQPGAAPGGGGVNAQYISQTLSQCVRDQHLEAFYPPQALDPIAQRVVQSGALQQLAANWKLPVELATDLVKIALFDVVVLIDDSGSMAFEQNGERIEDLKMILGKIAFACSLFDHDGIQVRFLNSQLQGNNINSDQAALQLVQQVKFSGLTPLGTALDQKILQPLLLGPARANALQKPLLVIAITDGAPAGESTDKIVQVITNANSELQRSRYGPDAVSYQLSQVGNDKSAQKFLSSLDDNPTIGQLIDQTMDYEYEQEQMKQKTGEELSPEMWLMKLLLGPIDTSYDSKDETNAPPRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MMU6</accession>
    <name>A0AAJ8MMU6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SCF-associated factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_103224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058800.1">
        <property type="nucleotide sequence ID" value="XM_070202699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MMU6"/>
    <dbReference type="GeneID" id="30170140"/>
    <dbReference type="KEGG" id="kpin:30170140"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF3">
        <property type="entry name" value="F-BOX PROTEIN POF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="183"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="506"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="586"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="689"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC69286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="710" mass="78566" checksum="BCD3F961FE3D824B" modified="2024-07-24" version="1">MSQGPTLTDIPNEVVLDYLLPELQLSDITSLSAVNRQFNILTSDPAFWRNKTLQDFTFPSTSHPFISNSNWWKRVYLGLLKPKSYVWGSSDNNRLGGAELNNNNKRFGRFIDLPSEINWINSKQGKNKNWSESLKDSLTFAISGITSSSTQISSNQDIFGDNDAGVVDLQAGGWSFTARQSDGSIWVWGQLDGSRPGFRLHSWDDKHCPCPHPTRIPVPCQAESISAGRRHLLILDSDNLIWELRAWGRAYHHTSSELTAPTGHGINRSPPHIIQLSTGWQHSAALTARGEIHVWYPFSDSYEQSLTLIGDLNGPVFDSEENKDERALKHGKVGEGVLITLPPIPTRPVRKDILAGDTREFEAKSQREENLEMAWAEYQSTRSLKLLEEEQRVVKIASGEDFLVALKKNGEVWLTVVKDGVAPKWQYMKYFSSPTITHLTAQFRSFTTYATPIKHSSKSAVYHTRLPDRIENVENILPDQLESLQNKGIIQIAIGDYHYAALNDKGEMFTWGQGDSGQLGRGRDRLGDEPTKVIFPQDQVDLKDNEGDEQEGSFVFSITAGGWHTGALVLGDLKSRKIPLEKQTKEIHNIEEDQEEESESGNWPRGLWNPFANNPNPAVPPTGPSNRGGGPVRAMPFYRVGFAGRGANLVGAGRGYSSAASDGQAQDHSEGQAVLRGAAPIVRVGFAGRGANVTGRGRVSGNSESEDEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MMY9</accession>
    <name>A0AAJ8MMY9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_102012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC68091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008338.2">
        <property type="nucleotide sequence ID" value="XM_019158592.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MMY9"/>
    <dbReference type="GeneID" id="30175264"/>
    <dbReference type="KEGG" id="kpin:30175264"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC68091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="184" mass="20892" checksum="6514850E32423292" modified="2024-07-24" version="1">MEILKLSSKGSKSTPSSLALPSKRIASIKPGPAFHPDPAVHEGKTVEGCEIWVIVMNEIVQSVMLLFTPGQSKRHSREKIGYEKEMMSNLSEEKRKWYSTGRKGSGTILVHKLISLLTPENPHIWLTSTHDEAIRFYRKVGFVIPFEDNIDFGERVGRFRGMLYKNHSPGIACWTRRKRIIDGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MNA8</accession>
    <name>A0AAJ8MNA8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinetochore protein NDC80</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I206_101553</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
            <location evidence="10">Centromere</location>
            <location evidence="10">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the NDC80/HEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058513.1">
        <property type="nucleotide sequence ID" value="XM_070202412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MNA8"/>
    <dbReference type="GeneID" id="30174844"/>
    <dbReference type="KEGG" id="kpin:30174844"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.30">
        <property type="entry name" value="Ncd80 complex, Ncd80 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005550">
        <property type="entry name" value="Kinetochore_Ndc80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055260">
        <property type="entry name" value="Ndc80_CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038273">
        <property type="entry name" value="Ndc80_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03801">
        <property type="entry name" value="Ndc80_HEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 10" id="KW-0137">Centromere</keyword>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="4 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Ndc80 CH" evidence="13">
        <location>
            <begin position="68"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="380"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WWC67643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="633" mass="71850" checksum="B6D1AA305F6663B0" modified="2024-07-24" version="1">MIGSSGGNQPSQSDRDKFKGLSGQASRRSTLNNIRSTETRELVNSVNRLHGTFGRTPQTSRNMPSSIRRSSVYASSNANRPSLQSTSHIAAPPKESRPVRDKNFQIECMRNLSDYLVNVRYPAPVTSKTLSSPTAKEFQSIFRYLASTLIDPGMIWSKKFEDDALTMLKDLRYPGLESISKTAFTAPGAPQSWPSMLAMLNWLVELCKAHDNWNDTNCISDPILSLPTELPLDHPYLEDRMLWNFASKTYNQWFDGGAEEFPEAEQELMEMYDRVSVANAEQTFSLAGILQKYQLELQQLQIQEPPLRKLEDEYLQLMGDKTKFIAFIDLHRQKADKTRQAILKIRAAVSEQRDELETHRSNLIVIENAIAAQNLSPDEVNRMNHERDSLHRALDDLRGKIAEASQASYDNEMLVTRGMDRFETLHAEYAALTHNIGKRSLQSEDDSENVPMFDADIDVDLGVADLDALKSIGTFMRSSIWQGLQSRRERYRQEKLTLDNHAIVQEDLYDRSRQEVERQMEEVSTLEVKLKMIHDQADAAQTKLATDNVNTNKVIAQLENEVTSMLAASQQGVLVSQSQLESDKIAYKELRHRTAILQDTLVSHIGIHIDAIIRAKEHTNNSLRSIRLIAEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MP06</accession>
    <name>A0AAJ8MP06_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cofilin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Actin-depolymerizing factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_102335</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin-binding proteins ADF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058646.1">
        <property type="nucleotide sequence ID" value="XM_070202545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MP06"/>
    <dbReference type="GeneID" id="30171051"/>
    <dbReference type="KEGG" id="kpin:30171051"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11286">
        <property type="entry name" value="ADF_cofilin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017904">
        <property type="entry name" value="ADF/Cofilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11913">
        <property type="entry name" value="COFILIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="6">
        <location>
            <begin position="2"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC68408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="138" mass="15842" checksum="D26F2998F311F87E" modified="2024-07-24" version="1">MSSGVQPTQECLEKFQELKTGKKLSYVIYGLTEDKKSITVLKSSEEKDFDAFVNELPEKECRWAVYDFEFTLPGGEGIRNKLVFVVWSPDDANVKNKMMFASSKDALRRRLEGIHIEIQATDFSEITKDAILEKALRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MPY7</accession>
    <name>A0AAJ8MPY7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_104093</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058994.1">
        <property type="nucleotide sequence ID" value="XM_070202893.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30172700"/>
    <dbReference type="KEGG" id="kpin:30172700"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000143">
        <property type="entry name" value="Unplaced genomic scaffold supercont2.12, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="173"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="721"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="940"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1042"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1475"/>
            <end position="1515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1527"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1575"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="522"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1318"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1490"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="262"/>
            <end position="269"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC70146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1606" mass="178170" checksum="DA81CE2D866521FF" modified="2024-07-24" version="1">MSLSPSKHRTLSRQPSSPSLAVGLPPALPESNIMQPSSPSKLAKSRSRKRIHRGDVSSSAASSDNEEEGLTQITPKRKIINPIEAPLPLSTGKKPKKKMTLQERLAAAASAKAGTSEGGIKAKVNSIADFSSFISEATQISESSSTSKVSMTPQTRSELLSSRSIASSSSSDKVVVCVRIKPTSHPFANIAYEISPTSLTLSDDHPKVKQRGGKAGREDGYTYTFDKLLQFPSTTPDLYGAKVAPLVDKAMNGFNSTIFAYGQTGSGKSFTMTGTADELGIIPCAIDGVFDAITADTERAFLLRVSYIEIYNETLRDLLNFKKGPLKDDEKPAIHYAKGKVYVDPLVEEIVSTPQDVIDLLEKGNAQRRVGATDWNERSSRSHCVFTIVVESRPRDGDGDDDIRLSRLNLIDLAGSEKAVSDSERRGEGKHINQSLLALREVINKLTEKTKASHVPYRNSKLTHLLENALGGDSNICVICTMSAEEEHCGETLETLKFAGRCSQVKTNAKKNVLQSSERALIKAKDQEIEDLRLRLATFTKKDVNPISDLAESVAAMEARKSKLVAQLSKLNGEILTSELPRSGSGLPLSPPKPKRRRISDFSAMISTGSGRTGIGLGTPKKTVDRRAISGMSRLTEESEEMAGIMGTLEQAAGGGVAKSFEQDRALAAARRNLATKEEELSLANRNLASALARASQLSERDAKISTLETELRQALDALSSTQQKLQRTESDMGDQNAQLESTRSEMVAKIEERSKRIDELENKVIDLRNSREELVLEDQGRLEEVQKRSEELSKEKEGLECTLKRLQHEALEQGGEVERLKGEIATLVDRGAETKAQTEISSLQIAQLEDSMTQLKKQLEENQYSQASREATLQTEKAIAERQVEEARADLDRFQREAMSNEANVLGQLRDEIGNLRKARDEDKLAFEKMRLELEREIEEGKERSKDELTQAKNEAEERERKLREQVAEALKTLQEAAKANDTLQQTIRLETESKATIQQEKADIVMKLVRATQDMEDIATSNKDLEERLQSALNIKTTLENERDEARNRLSASDGAADQLKSETNARQDAEVRLELAINKLHEMEDRLGAMQKDLEVQEKRLEAEAASRQDAENRIQDIALARDQAVAAEREKEKAADEEKKCRIAAEKRIEELSMQREANLEGVKEMRRKMDLESSSRKEVEAELEKLKARQSAENSGQDKLRAKLLETINAKEELSRQLSELVQSVKKKDEELRSVLATRNDMSNTIANLEEVHKALVEQNEKAESCLKTAENKIATHSALERSVLDLRHQLEAERTGRIAAESQVTKVSQELITKHESAQQVLENELISLRQALKVAQKEKSDAQSEAELERVKADELCSELNELKSRSEVTITTSVSSRLRHSAPGPGWGTDKDMSATALDSLRSRRGVSAGTHVLDASLSMLKARDDDEIERLERIIEVQKEIIDEQREKIERWAKEMEKQREIVRLLTNDNSQPSPIPARTRSPRGHGKSHSISHSPAPTPLPNAKGLVSSFTARNLALPTSPSPLPMHPSQFTNSSARKARRVTIEHDMDKLTESSKVIKAKAIFESPEKNAAPATPPKIPLRATQSIRSVPRQRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MPZ9</accession>
    <name>A0AAJ8MPZ9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_103367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058838.1">
        <property type="nucleotide sequence ID" value="XM_070202737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MPZ9"/>
    <dbReference type="GeneID" id="30169997"/>
    <dbReference type="KEGG" id="kpin:30169997"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31794">
        <property type="entry name" value="AUXIN EFFLUX TRANSPORTER FAMILY PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31794:SF4">
        <property type="entry name" value="AUXIN EFFLUX TRANSPORTER FAMILY PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC69428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="328" mass="36021" checksum="F87C9F7C8A1400A2" modified="2024-07-24" version="1">MLQSASEILSTTWSAVEVSDIKCKLLSKEGEENASKLCVTLFLPALLFSEIGPLSSWENLQQLFQIISWIFGTVGVVAFGMPRWIISLGKNGTLSPLTKGDELDGVLDRGQVYLLINALVANLTRFSLGPIMMKRHPLDVPHPWSHSESPHAVKKVKEVLSGGYPEIEPYSDDENAPLLDQAREGGKKGWKILKIVKNCLAGFMNPPMYGGIAAILAGVIPFLHNWLFTKGAWLSPTKNGSRPPIFPLMYLFVIRFAVMPVISISMVYGVRKALGDRILSDPVLIVEMSDTDENVETAVAKTIVISYALSPLISFSVTAALHVVQKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MSR1</accession>
    <name>A0AAJ8MSR1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_105981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059321.1">
        <property type="nucleotide sequence ID" value="XM_070203220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MSR1"/>
    <dbReference type="GeneID" id="30173173"/>
    <dbReference type="KEGG" id="kpin:30173173"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="789"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
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            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
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    </feature>
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            <end position="337"/>
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    </feature>
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    </feature>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC72022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HS97</accession>
    <name>A0A1B9HS97_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_07823</name>
        <name evidence="9" type="ORF">I206_100008</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV700119">
        <property type="protein sequence ID" value="OCF46153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007372.1">
        <property type="nucleotide sequence ID" value="XM_019159508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HS97"/>
    <dbReference type="GeneID" id="30176192"/>
    <dbReference type="KEGG" id="kpin:30176192"/>
    <dbReference type="OrthoDB" id="10261634at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="447"/>
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        </location>
    </feature>
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            <begin position="471"/>
            <end position="489"/>
        </location>
    </feature>
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            <begin position="509"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="547"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="605"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="330"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
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        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
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        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF46153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC66108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="635" mass="68252" checksum="14D20D58E152E776" modified="2016-11-02" version="1">MSHQSTYLAPTAQQPISKYIPQSPQPDSPPQTPSPISPGKPTLSLPHREMIDSAGESSQSKDKTPTGTPEGYTYNSGNTSGIALKRSDSHTSATSIGIGINFPGDSNPLPRELHSPRINGNGNGNGNGNMTLPPVPVQMQRRKSSDGSVIIPFATDNSPSSAGMSLSLSAGSTSNPTPQQNLSPFPPSTSSQFSNTPPRPRTVSPRHNTNNSSTFASSSALGKSGSGYEPRERVLSPQKSDIVANNGVFHNNGSNEDLSNHNHNHNSIDPNNPYDTHGTKEKPSWQHANSSFATFGGVGSQPYFPLTGKDNLLGNSPTVHPKKVPFTDSVGFWLGLYFCFNLGLTLFNKFVLVSFPFPYTLTGLHALSGCAGTYIALEQGAFTPARLTQKENVVLAAFSVLYTINIAVSNISLQLVSIPFHQVVRASTPLFTIFISAIFLRARFSYLKLISLLPVVAGVGFATYGDYDFTALGLILTLLGTFLAALKTVVTNLIQTGGGGRLRLHPLDLLMRMSPLAFIQCVIYGWYTGELERVRRYGATQMTRSKAIALLFNGVFAFGLNIVSFTANKKAGALTMTVSANCKQVLTIVLAVMLFNLHISPTNGVGILLTLVGGGWYGYVEYMEKKKKTKVLERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HSD9</accession>
    <name>A0A1B9HSD9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-glucuronidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_07856</name>
        <name evidence="5" type="ORF">I206_100041</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700119">
        <property type="protein sequence ID" value="OCF46186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007405.1">
        <property type="nucleotide sequence ID" value="XM_019159541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HSD9"/>
    <dbReference type="STRING" id="1296096.A0A1B9HSD9"/>
    <dbReference type="GeneID" id="30176225"/>
    <dbReference type="KEGG" id="kpin:30176225"/>
    <dbReference type="OrthoDB" id="2796951at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF2">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628077" description="Beta-glucuronidase C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-glucuronidase C-terminal" evidence="3">
        <location>
            <begin position="477"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="613"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF46186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC66141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="666" mass="70283" checksum="25B744B4AC998956" modified="2016-11-02" version="1">MKSISPLSWLTTLSILSSISGQSLTVYTGGETATATSTATAASGTYTGLAAYDPTVLTPPSAPATPVTSYTLTLPTNSQAVLDAGLSLSISQKGNFLGFSVELSIANSLMGSSSTNLKVPFLNYMANIQNRAGVGPIIRVGGNSQEGSSIFVGGLADGAVLDKIKVSSGVTDTPLINYSLELFYLMANVTSLVGADWYFGLSFNESAVDYPTGNVPIAAKWAQDILGDSLLALSVGNEPDLYVDHSKRESGWGVSNYVTEFDNMTQSILANNNLVDTKAFIGPSTCCQVVGFELDDVLNAGWLNDNVNNLAAVSVQHYPTNNCQINGNVINPQDIFSDFLNHTSAQAQVSPYLGNAATLQGAQKEFVMLETNTASCGGFAGLSDSFGAALWMTDYALQMAWGNFSTALMHVGGQNVYYNPFTPPPSTDASTKQWTTGSIYYSSLVVSETFGKSNQSKIVDISPTQDTDANYIYHPIYAVYENDAPTRVVLFNYIDDSTGANDLQTTINVGTNVSSVSVRYLRASSVSEQYNITWANQTLGTSFASDGRLYGNQETITINCQDGNCIIPVPAPSIALVFLTTDALTNSSPTESSKTAYETSVVGTGSATVDKQSLETSNGQNSNNTGGGTSKGNTTSGSIIKIQSPISLILKTSVLIGFISILSGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HSN2</accession>
    <name>A0A1B9HSN2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_07734</name>
        <name evidence="6" type="ORF">I206_103785</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700118">
        <property type="protein sequence ID" value="OCF46257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC69842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007476.1">
        <property type="nucleotide sequence ID" value="XM_019159424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HSN2"/>
    <dbReference type="STRING" id="1296096.A0A1B9HSN2"/>
    <dbReference type="GeneID" id="30176103"/>
    <dbReference type="KEGG" id="kpin:30176103"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000059">
        <property type="entry name" value="N-ethylmaleimide reductase, FMN-linked"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF93">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="4">
        <location>
            <begin position="9"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF46257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC69842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="403" mass="44939" checksum="C2AF68E3BF70BBA1" modified="2016-11-02" version="1">MTKIQEVDIWTPIQIGDCHLAHRAVLAPLTRNRGTRSVEDEHTWVPNELMKTYYTERATPGGLLITEATPVSIRASGLYGIPGNFTEEQQKGWKTIVSAVHTKGGYIFNQLWHQGRTTHSALIGDKTPESSSNVPIDGTFQWNGFSARPYEVPVAMTKKAILDTQDDFVQAAKNAMAVGFDGIEIHGGNGYLFDQFLHSNINTRTDDYGGSIENRCRFIIETVEKLCNAIGPSKVAIRLTPFGLFGQTYGSDRLQQWSYLCGQLGKFGLAYVHLIEPRFDELKSAYEKQSALKDMVEQGVEEVSLRPFRKALGESTPIVTAGGFGPQNMNDGIKNGVSDLVAFGRYFVANPDLIDRLKSKKPLYKWDRSRFYGPFDDNEFGYTVFGERELASEGDILKAQLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HSW1</accession>
    <name>A0A1B9HSW1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_07589</name>
        <name evidence="2" type="ORF">I206_102221</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
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                <person name="Cuomo C."/>
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                <person name="David-Palma M."/>
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                <person name="Mohammad A.W."/>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Shea T."/>
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                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
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                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Griggs A."/>
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                <person name="Imamovic A."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 10737</strain>
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    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </evidence>
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        <source>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Pearson M."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
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                <person name="Imamovic A."/>
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                <person name="Saif S."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="6">CBS 10737</strain>
        </source>
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        <property type="entry name" value="FI04035P"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR45876:SF8">
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        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00139">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="RhoGAP"/>
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    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
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    </dbReference>
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        <property type="entry name" value="MYTH4"/>
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        <property type="entry name" value="RHOGAP"/>
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    </dbReference>
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        <property type="entry name" value="WW_DOMAIN_1"/>
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    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="230"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="MyTH4" evidence="4">
        <location>
            <begin position="630"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="871"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="463"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="484"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="704"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="68"/>
            <end position="82"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="102"/>
            <end position="139"/>
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            <begin position="146"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
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            <dbReference type="EMBL" id="OCF46903.1"/>
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            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1076" mass="116996" checksum="50B8363009F9C137" modified="2016-11-02" version="1">MSTSIQSHNSTSSYQIQSPITPTKSQNHAPITLSDPIQITPIRNNTLPPSYKSLPNSSIKSFNPTINRQEEKQALRDARTQIEEEIENNRGNLPSGQIEPESNNSSSGSASGSGGNAVPSSGIDNNDNGKIDGNINNHNQPNGSSLDEENNQNDASQEENNLEIGYRGYLPPGLDVRDALAKCEDPTLGWSLQFWVTIADPLTQHVFFACPASGQCSWDPPVGAFVVPRSPDGEWWELADSTRGNRSYYYNTLTGKTQWTRPGGNAFVIPLGLIQAAALPTRPQPQSPSNPSSSRIVSTTPSRSNRQNRSSGLFSPNSLQTPNSAGRSNSYPQLLHSPLKSIPRPIHSPSKSIRSSSLTPSSSVETNFGNANEPSQTLEAIVMGHFASPSSYTSNINGNENQSHPLIREGISGGSRESEQTHSTSNSMSSNPATSSHLSVVEEGSGNETDMSDFTATGSAGGGWWEKRKSQVLTVKTGFKSPGRKFKGLSLSDNGSPIDGMNSSAARGSPLKKSRTAITGPIYESNESTAESLVSETPTELTVLNGINGTSGCFTPGLTRNNMPEGPIYVDNVGTVKTKRLSTGLHPLLPFEISSEILAIQTDDFARKYFATKRSGIMRQKVPVEVIINHQKSPINQPLLVLSKNLNKDAIITFKVIQHVMGEREKPVEGAKPFMSSSSHLNLASLALGGRKGDLGHPDRNGKLANGFGNLSGNGNGNSENGQSYDGNISDKNWSGNGNGGEKKSDKIQVLEEIRWLIQLCVASSEMRDEVYCQLIKQLTKNPNHDAVVLGFQLFCVLVNAFGPSKNFEPFVKNFLRSTSDEKADGIGIMSKYCIGKLDVLTAKGGRGKALTIGEIEHASDAAFYPSVYGESLDRIMELQKRAYPDLKVPVILPFLADGILALGGLESEGIFRVPGDADSINELKSRMDRGHYQLKGINDPHVASSLFKLWLRELEDPIIPFSLYNDALQASKSIENSINFLNKLPLYNKRVLLFVINFLQLFINKEIIKKTKMTSGNLALVMAPNILRTTSNSLITVFTNSNFETKFILQLLENLNPKLIDEEYIPEHGKPIGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HUK5</accession>
    <name>A0A1B9HUK5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Glyceraldehyde-3-phosphate dehydrogenase, type I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I206_06728</name>
        <name evidence="14" type="ORF">I206_102178</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NADP(+) = (2R)-3-phospho-glyceroyl phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10296"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; Calvin cycle.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
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        <property type="protein sequence ID" value="OCF46954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC68255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008173.1">
        <property type="nucleotide sequence ID" value="XM_019158427.1"/>
    </dbReference>
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    <dbReference type="STRING" id="1296096.A0A1B9HUK5"/>
    <dbReference type="GeneID" id="30175097"/>
    <dbReference type="KEGG" id="kpin:30175097"/>
    <dbReference type="OrthoDB" id="1152826at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047100">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18126">
        <property type="entry name" value="GAPDH_I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05214">
        <property type="entry name" value="GAPDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000002">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF134">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (PHOSPHORYLATING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="12">
        <location>
            <begin position="31"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="40"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="197"/>
            <end position="199"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
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        <ligand>
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        <source>
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        <source>
            <dbReference type="SMART" id="SM00846"/>
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        <source>
            <dbReference type="EMBL" id="OCF46954.1"/>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">CBS 10737</strain>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
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                <person name="Gujja S."/>
                <person name="Hansen M."/>
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                <person name="Imamovic A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 10737</strain>
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    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
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                <person name="Berlin A.M."/>
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                <person name="Griggs A."/>
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                <person name="Hansen M."/>
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                <person name="Imamovic A."/>
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                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="2" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700117">
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        <source>
            <dbReference type="EMBL" id="OCF47105.1"/>
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    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC68106.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="172" mass="19170" checksum="FD55B9EF97744B70" modified="2016-11-02" version="1">MASSPSGETSLSITDGLEIESLDSQSLFIALTNVEKAIPELLLCIKPILSHLISSSSSLDNQLNQSNEDEISGIQAREGVEKYMNLLDKIQFILRQTVYYLKVKKIQKSILNPTLINNLPNPFSNSISSSSLNNDSNQQVELGLYSNRIEEKILNDMINSIKNLKDEQQKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HVJ6</accession>
    <name>A0A1B9HVJ6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
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    <organism evidence="15">
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        <lineage>
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    <reference evidence="15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Mitochondrial ribosome (mitoribosome) assembly factor. Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body. Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = 2-dehydropantoate + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the PanB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="4 13"/>
    <dbReference type="EMBL" id="KV700117">
        <property type="protein sequence ID" value="OCF47292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008511.1">
        <property type="nucleotide sequence ID" value="XM_019158765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HVJ6"/>
    <dbReference type="STRING" id="1296096.A0A1B9HVJ6"/>
    <dbReference type="GeneID" id="30175439"/>
    <dbReference type="KEGG" id="kpin:30175439"/>
    <dbReference type="OrthoDB" id="425211at2759"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000047">
        <property type="entry name" value="3-methyl-2-oxobutanoate hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015324">
        <property type="entry name" value="Ribosomal_Rsm22-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001452">
        <property type="entry name" value="PRK00311.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881:SF0">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09243">
        <property type="entry name" value="Rsm22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="188"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCF47292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="WWC67921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1050" mass="115780" checksum="6E92525C7624A9AB" modified="2016-11-02" version="1">MLPRPARIIHQYHLAPRVVRQQQRKFTSTSHVRGPAAQAQVVRDHVPSPSIDESFKELIQEDDMAMGMGYKRSIKSSITKGKGRMPDLDVVHQASSNASSGNHGFGLMLHNDDIGSQLGRSEQEDDDYIHERREERRSPAAVLGSKRLGVVVLPQVMKDGIQRQIDQLDNPRTLRQSYLDLPATASSRQRDEKVDHRSSKPRKTIESELAKAAGILPGEYGVVRNIFEEMNRRLGKGWLESAMPAEEVKDIVEFSGGLGAGLWSAISGLEGSSTNAKKRIQLVHSSRHGLDLAKKIIEDASQQDTEIIFNRKHHYYGSTPSLVLSTFLLSTLPTQPSQNSHLLQLLSLDSPYIILVDRSSPAGWEAISRARSFLLDQSTSENPLHVVAPCPHDGICPLTLTDDKCSFSQRLQRPSFVRKTKHSSRGEEDTGYCYVVVARGTRPALVDQSPQGLATGRIGGVGKEEAEKIRLKNDGRSVLREIEGHEGVLEVVNLPEYENPESLLNLPIDQADRQQLELNLRKESFSWPRLVAPPMKRSGHVTMDACCSDGNIQRLTFSKSHSKQGYHDARKSTWGDIFPHTPKSTPVIRTRGVRRLTKPVKDDQVLSELIAAQAEEVSDVDQAALLDELKELERLGIKVPKAEIIEEVEGELPGSTVRGGSFGAEGQRRSFSTVSNRPKLHNVGLSYRIQTRSMSARPPPRAKVTLATLKKLAKANIPITVLTAYDYPTALLSESTGVDMTLIGDSLSQVCLGHTSTTEITLDEMIHHAKAVARGARTPFVFADLPFGSFEISLEDAVRNVIKLIKESGIDGVKIEGGLEIVPLVKRLSEIGIPVMPHLGLQPQRATSLSGYLVQGRSAQGAYDILNTARAMQNAGAFAVLIEAVPDKVAKRITEELDIITIGIGAGNGTNGQVLVITDVLGTYAEDPEVDLQESIMNDGMEPAAKLALDHMDKPIPTQPSSTKVISNNQIVSTTNTVIRSSIEVEPIRKPVNAPKFVRHFGNNGIQSRRAIREYLNAVRDGSFPNQNESYGMKKEQWEEFLRLLETEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HVP8</accession>
    <name>A0A1B9HVP8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chromosome segregation in meiosis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_06240</name>
        <name evidence="10" type="ORF">I206_101788</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays an important role in the control of DNA replication and the maintenance of replication fork stability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CSM3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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                <person name="Heitman J."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="Sun S."/>
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                <person name="Zeng Q."/>
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    <reference evidence="3" key="2">
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="Mohammad A.W."/>
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                <person name="Yurkov A.M."/>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
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                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="12"/>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008952.1">
        <property type="nucleotide sequence ID" value="XM_019158339.1"/>
    </dbReference>
    <dbReference type="STRING" id="1296096.A0A1B9HWT4"/>
    <dbReference type="GeneID" id="30175008"/>
    <dbReference type="KEGG" id="kpin:30175008"/>
    <dbReference type="OrthoDB" id="6755010at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05776">
        <property type="entry name" value="DNA_polB_alpha_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05532">
        <property type="entry name" value="POLBc_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000004">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000003">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000036">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2820:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3200.20">
        <property type="entry name" value="DNA Polymerase alpha, zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024647">
        <property type="entry name" value="DNA_pol_a_cat_su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038256">
        <property type="entry name" value="Pol_alpha_znc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045846">
        <property type="entry name" value="POLBc_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015088">
        <property type="entry name" value="Znf_DNA-dir_DNA_pol_B_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861:SF1">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12254">
        <property type="entry name" value="DNA_pol_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08996">
        <property type="entry name" value="zf-DNA_Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase alpha catalytic subunit N-terminal" evidence="17">
        <location>
            <begin position="7"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="15">
        <location>
            <begin position="517"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="14">
        <location>
            <begin position="824"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger DNA-directed DNA polymerase family B alpha" evidence="16">
        <location>
            <begin position="1308"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="50"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OCF47733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="WWC67483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1499" mass="168376" checksum="D507A4C5E5470FA2" modified="2016-11-02" version="1">MAPAKGLAALREARAKGGRLGQWKPSESELYDEVTDDQYRSIVGDRLDADDFIEDDDHGGYVDNGMDDWDNGRDEDESEDEDAFEGEDEEFRKARLLKKQKARARANAGKPLAKTNKPKAKSAFSDYARPVASSSSSTYRPAPNAMQEDDFMASLLSSVTSTANDTAARKRKSSPDIPSSEGLHPSSDSSFFSSSGRKRYGIEEDDEDDDHNSPSIWDAKRGVMGKKPRMSDITVVPSHQDYDQENDFIMDVDEEEIMVKPELIDEDEEDDEMQIRKIKPLAATTANLNGATTARRKVINSNSIKNVLKPDPVKVKAEPIDEDNIEIVKPRLSSTSTPRNGKVLNGASHWSAIQESLLQPQTKGSELEEVKASFSSVKAENVLEEDGSLSMFWLDHFEQDGVVLFVGKVLDRQSGKHVSACVSINGIERNLFVKPRAKRVVQGQETDDDVSRTDVFTEFDSIRRKAGIEEWAASYVQRKYAFEDKSVEKGESEWMKVAYGFDQPEIPMGTTGQTFSHVFGTNTTPFELLVLKRKIMGPCWLKIENPTLSTKSASWCKIEFTVSDPKTVNPFSETDNAAPKDTPPLTIMSISLRTIVNHRENKTELLCATTRTWEGCNIEDPTPPDQLRSSLNTIIRPIEKFPPGLEQRGKTDKSPFQTVKAERALLNSLLATIQRFDPDVLVGHNFLGNTFEALLYRLKELKADHWSRIGRFRRKGFNISKGGSNHRLLAGRLVADLSSDAVKGMISSTTWSLTEMCGTHLKIQREDVDPEDTHSYFDHTLSSPDRLVKFIRLCEVDAFFQMAIAARVQMVPLTKQLTNLAGNSWNLTLNGGRAVRNEFILLHEFHRLKYVCPDKAPFKSKKHVVNDEEDTEDIATKPIGARGKAKYSGGLVFEPKRGLWDTYIMVMDFNSLYPSIIQEYNIDFTTVEREVEDDSGETEEKIPDVPASDVSQGVLPRIIATLVNRRRQVKGLMKNKSATPAQLLQYDIRQQALKLTANSMYGCLGFAGSRFSSRPLAALTTFKGREILTHTRELAESLQLDVVYGDTDSVFVNSNVTSLPEAHRIANDFKKLVNERYKLLEIDLDAIFERILLLNKKKYAAVKIEDNGERKTEVKGLDMKRREFSKVSKDASSAVLKEILSGESTEIVVEKIHELLTNLGEAVKNGLIPLEDFIIFKRLGKNPEDYPDKKSQPHVQVALRMKSKGASVRAHDVIPYIMCLDESGKGGKTAQAERAFHPDDLRRQGSELKIDYDFYLDTQILQPVLRLCETIEGTERARLAECLGLDPSRYASSGPSVSDEKQFFTFESQISDKERFKDAEPLQLRCVSCESAFTFQGLMDESTNIQPVGISCSACQAILHPASVSVQLENQIRAHVSRYYLGWTVCDGEGCGARTRMMSVYGKRCLGLVKEGCKGTVRLEYNDSKLYNQLLYYRSLFDGEKAISNARGSQRFEEIRALVLPNTALFGQLVQVTDKYLDKNGRRFVDMKGLFGFMERIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HWZ0</accession>
    <name>A0A1B9HWZ0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Allantoate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_06691</name>
        <name evidence="9" type="ORF">I206_101341</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
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        <property type="protein sequence ID" value="OCF47784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HWZ0"/>
    <dbReference type="GeneID" id="30175060"/>
    <dbReference type="KEGG" id="kpin:30175060"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF59">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
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    <keyword evidence="2" id="KW-0813">Transport</keyword>
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            <end position="157"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="194"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="467"/>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF47784.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC67433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="560" mass="62691" checksum="8CFF5183F39DAF3A" modified="2016-11-02" version="1">MATEKHYSPTHIEDEKVLPIDHIETAHHQIDPEALHSTKKQGANNQLDDAARLLAEAGGHVEYTAEESKRVLRKIDLFVCLPMCLVYFIQQLDKSSVSYSAVFGLQKEAGLVGTQYSWLSSIVYIAQLICQPLSSYALIVFPVKYWVMFNMISWSIVTIVTCVGKNFTGLLICRLFLGIFEATILPSFVLITQMWWLRREQSYRTIAYQIANSFAAIFGPLLSYAIGKATESSNVIRPYQGIFLFMGSFSLALVPIVWWLMPNSPTTAKFLRNGNDRLIAIDRLKENNTGTKASKFKWSQVRETYKDPKTYMWAGMWFCAACPSGGIGAFGGLITKGFGFNTFTTILMQIPTGAIGITALLLCIFITNRIKMRWPVLAVVVLFPIAGAVSLTQVNHKKVGGLMASYYVAYLFAAIQPLLISWCNLNAAGTTKRVVTTATMFGALTIGNVVGPQVYLTREAPRYHTGLYVDIGCWCVEFILVVSMGFYLKYLNKKQEARRVALGLPANLKDISIMDTAEADAYKLELEQMMAQAGVNRDLLNENAFDDMTDWENPMFMYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HX29</accession>
    <name>A0A1B9HX29_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-directed RNA polymerase III subunit RPC4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_05686</name>
        <name evidence="7" type="ORF">I206_107360</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI894014">
        <property type="protein sequence ID" value="OCF47826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC73393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019157405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HX29"/>
    <dbReference type="STRING" id="1296096.A0A1B9HX29"/>
    <dbReference type="GeneID" id="30174055"/>
    <dbReference type="KEGG" id="kpin:30174055"/>
    <dbReference type="OrthoDB" id="5836119at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
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        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007811">
        <property type="entry name" value="RPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05132">
        <property type="entry name" value="RNA_pol_Rpc4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="389"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
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        <location>
            <begin position="306"/>
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        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="324"/>
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        </location>
    </feature>
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        <location>
            <begin position="395"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF47826.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC73393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="531" mass="57430" checksum="7AE86FD5D9466B98" modified="2016-11-02" version="1">MSVPTRGKPSLIAAAQQQGQPSQSQLTSNQPLPSNVTSIPMSTVSSSQSGTGTGSISARSTPAPTARGEGSVPPGGVQRMKFKPKVPIRRTVKQEVDVKPDISSLPSASQPTARGGAARGAPRGRGGPGRGRGRGNAPSTSIAAGVFGGPRPVAAASSSRRFAAAAAPTTRGYDEQDAEVYSDHSDVEGGSSGRPIDIDLVSTMSESAPTSLFRDRRLNQDKKAQGKDDKQDKRSKKKSKSKPAEAEPTMDVDVGPRVKDEPISPEKRATPLREDDTMLSDDELQDRDDQGRRVRNFAQTGGNDTPLDEDEDEEVNEAQMVDLSESEEEEEEEDMEGDFVQSEGYDNPEEKLFIFQFPHLFPKFLPSTTVDLTQNDIKPDVTAHVNGATNAAQQKDVKPDMKPDVKPSAAQLRAAQSKKGPEPVPEGRVGTMVVMKSGKVKIVMGKDIVMNVTPGLPTTFIQHLVHLEPKKKTAQVLGEIHKNYLVTPDIDRLLEELYINGGQTPGEVETERRKRLMKESRGLVAMKKERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HX77</accession>
    <name>A0A1B9HX77_9TREE</name>
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        <recommendedName>
            <fullName evidence="2">DSBA-like thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_05732</name>
        <name evidence="4" type="ORF">I206_107406</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894014">
        <property type="protein sequence ID" value="OCF47870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009089.1">
        <property type="nucleotide sequence ID" value="XM_019157449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HX77"/>
    <dbReference type="STRING" id="1296096.A0A1B9HX77"/>
    <dbReference type="GeneID" id="30174101"/>
    <dbReference type="KEGG" id="kpin:30174101"/>
    <dbReference type="OrthoDB" id="1930760at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
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    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="CDD" id="cd03024">
        <property type="entry name" value="DsbA_FrnE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
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        <property type="entry name" value="Thioredoxin-like_sf"/>
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        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="THIOREDOXIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="2">
        <location>
            <begin position="6"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF47870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC73437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="248" mass="28010" checksum="797AA22CFF54B5EF" modified="2016-11-02" version="1">MSVKKIDITSDVQCPFCLIGVKQILNAVEKYKTDHPSSGEYQIRLLPYQLDPTLTDKPKSRIQMYKEKFGEEKAEQIMAAMGPRLESLGFKSDYGGTVSSTHLAHRIQTYALLKNPDKQIPLAMDIFEGFHGYKKDPSDKEWLSSLAVKHSIFQNEKLALDWFNGNECCEQVKQSYTIAKRLGVTGVPFFVFQEKYAASGAMGEDEFYKLLEEIDKRESTPKQDQPAIIAHGESCGHDHHEGEVCPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HXF0</accession>
    <name>A0A1B9HXF0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cell division control protein 45</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_05812</name>
        <name evidence="8" type="ORF">I206_107483</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC45 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894014">
        <property type="protein sequence ID" value="OCF47947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC73512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009166.1">
        <property type="nucleotide sequence ID" value="XM_019157526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HXF0"/>
    <dbReference type="STRING" id="1296096.A0A1B9HXF0"/>
    <dbReference type="GeneID" id="30174181"/>
    <dbReference type="KEGG" id="kpin:30174181"/>
    <dbReference type="OrthoDB" id="10258882at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902977">
        <property type="term" value="P:mitotic DNA replication preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003874">
        <property type="entry name" value="CDC45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507">
        <property type="entry name" value="CDC45-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507:SF0">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 45 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02724">
        <property type="entry name" value="CDC45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="176"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="508"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="176"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="510"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCF47947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC73512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="717" mass="80116" checksum="5659485D5B99E04F" modified="2016-11-02" version="1">MPLLLPPSDDLRPSDLTYTHAYNSIISRVRRKGGAGNGGVVILAGTDVDGLLGARILCSLFKNDDVPYRLVPVGGYSELDSRRDEALASEELHTLILLSLGSLLTLSSYFELPPTCHLHIIDSHRPWNLQNLFGVDIGLDEVGEGESSEGKIWVWGDGDEFSETMDNVKKSWEALEYEPSDSGSSDDESEDDESDEEAEEDEEEDVDEEDNEEDDGDGEGSPSKRARKRRKAGSTEPVAKSKRQKENVDRPRRLPRAVREAHHERIQRYYNAGTSYGQSVALTIYLLATVLERADNDILWYAILAVTNQYITSRIDRDSYESFQIIFQDEVVRLNHDPAATNGGIKIPNPDDRSIAKSEELRFMLYRHWNLYESMLHSGYVAGRLGIWKEKGRKKLQGLLAKMGFSLQQCQQTWSHMDMDLKRKLPEKLESIAPEYGLVELSYPSFTRAYGFQLSSLSAADAVEVISSLLNIAVGVRLEVDREGGKGGGEWFGGTTRWNVNTRESASIAEGKENQDPNKNGEDPALDGTQVEKKKENWGSTNFWIAYDACDDIALIRRSLPLSMTLHRSIIRAGSALLDKTIIRSLRTFRLAILKEGPDLKIFSHPSTLSRLALWLVDATRDRWAERQSKLNNGGKVKSLPFVVACLNEDKGSYMVVGVTGSPEFGDVRKNKFGLAFQNAAEESGSGAKHDMFDTSVVEVAQEDLQQFIESLHLRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HXP4</accession>
    <name>A0A1B9HXP4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ADP-ribosylation factor GTPase-activating protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_05909</name>
        <name evidence="9" type="ORF">I206_107576</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894014">
        <property type="protein sequence ID" value="OCF48042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009261.1">
        <property type="nucleotide sequence ID" value="XM_019157621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HXP4"/>
    <dbReference type="STRING" id="1296096.A0A1B9HXP4"/>
    <dbReference type="GeneID" id="30174278"/>
    <dbReference type="KEGG" id="kpin:30174278"/>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030100">
        <property type="term" value="P:regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08830">
        <property type="entry name" value="ArfGap_ArfGap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000014">
        <property type="entry name" value="ADP-ribosylation factor GTPase-activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46395">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46395:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="7"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="122"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="345"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="161"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="388"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF48042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC73604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="417" mass="44588" checksum="848BF008A0B7D52A" modified="2016-11-02" version="1">MAEIYQKKELLALMNTGNNKLCVDCNAPSPQWASVSYGTFICLECSGIHRGFGVHISFVRSITMDKWSEEQLKKMKLGGNEAFKSFIESYGPDGGYSKGIGMQEKYNSWAASQYREKLAAACADPPQSWSPSAPPPASAAPSRPSSAQATRKSRAGGAGIGSSNLNPSYAPNPSQKDQNEAFFERMGNSNASRPDDLPPSQGGRYQGFGSTPMNDTSSQHPSYGLSSHSAPTLDELQKNPLGALSKGWGLFSSAVTSAASEINQTVVKPSVARAQEYAQGEQSEEWKKYLSNATSQAKEVGGWASTKAGESWGTLNEVTKTKGGIDLNEQLSKLGLNSVVGVGGGSSRQNGYGQLERSGDAEDGLITPHGGDNEDDFFDSWDNHSKQSTTSTTTGKANVNGGAKKKDGWEDDEWKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HXW3</accession>
    <name>A0A1B9HXW3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein ARV</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_05980</name>
        <name evidence="12" type="ORF">I206_107645</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Regulates also the sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Golgi apparatus membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ARV1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KI894014">
        <property type="protein sequence ID" value="OCF48112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009331.1">
        <property type="nucleotide sequence ID" value="XM_019157691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HXW3"/>
    <dbReference type="STRING" id="1296096.A0A1B9HXW3"/>
    <dbReference type="GeneID" id="30174349"/>
    <dbReference type="KEGG" id="kpin:30174349"/>
    <dbReference type="OrthoDB" id="2192830at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Dewar J."/>
                <person name="Goldberg J."/>
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                <person name="Gujja S."/>
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                <person name="Imamovic A."/>
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                <person name="Nusbaum C."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="Dromer F."/>
                <person name="Young S.K."/>
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                <person name="Gargeya S."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Chapman S.B."/>
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                <person name="Gujja S."/>
                <person name="Hansen M."/>
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                <person name="Imamovic A."/>
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            <strain evidence="2">CBS 10737</strain>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
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                <person name="Heitman J."/>
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                <person name="Young S.K."/>
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                <person name="Gargeya S."/>
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                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
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                <person name="Imamovic A."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
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                <person name="Zeng Q."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
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                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
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                <person name="Young S.K."/>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
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                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        </source>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF48508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC73201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="318" mass="35431" checksum="34033463D68CD59A" modified="2016-11-02" version="1">MVYFATFILPFLVTLPIFILSKPNPTPTDPLEVRGYDNYPKCYNYETRDPHTCKCYSEYEEPKNNWYYKRAEETTIAQVDTQSKKGGEHHLEECICPDYPNTELDDGWGIGDWKRKGKDHEHPKCVCKGNHQTYNAHTRKCECIKNWCPWTPSTHDKRSGKKGGYGHHGLDCKPCGPTGSPTPPGNGGGGGGGGYGGGYKKRSPSLHEAMQMRKTDSRGVEDFMGCKDQEKACESNGNWKCVDVSSLLWSCGGCPGDGVDCGSVPGVSEVTCHQGRCLIESCRRGYKLTDKPDIDYFTNTTCVNENDSPRHWFVAQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HZ74</accession>
    <name>A0A1B9HZ74_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Thioesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_05368</name>
        <name evidence="4" type="ORF">I206_107088</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lcsJ thioesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC73122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009808.1">
        <property type="nucleotide sequence ID" value="XM_019157090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HZ74"/>
    <dbReference type="GeneID" id="30173737"/>
    <dbReference type="KEGG" id="kpin:30173737"/>
    <dbReference type="OrthoDB" id="265761at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051490">
        <property type="entry name" value="THEM6_lcsJ_thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475:SF4">
        <property type="entry name" value="PROTEIN THEM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF48589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC73122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="382" mass="42626" checksum="E91F5D7479277893" modified="2016-11-02" version="1">MSAHIIAQLPTALVDGVKAILTKLSMDSSKPLLPFIPKPIKALLLILFVLHSPSWPFQWHIRVWYWGIKAYYLAYKKGRSKYLKDWKVQSNKNGGIKDLRTRIHRIAWIDDCDYNLHLSNSSYAKNSDALKMKWCIEALSPLFTSGSHMALGATHYNFFKEIPLGAEYVMEARCGGWDEKWFYVVIEFILYPQKSSKAKSKTEKAKIATENSVISVTEKASETITESTATLVPSISDPPTRSTSPALPTTNGTSTPQFASSKVEEIKRSWAVKRGQRADGGVVCCSTISEYCFKMGRVTIPPRIGLFLSLQSPLKSDQDRARKIVMSKDGGRAFLRGGWKEEADAATLGGDIGLKEEDDEQSNWVLKARAGMENVVEGMSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HZA5</accession>
    <name>A0A1B9HZA5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_05403</name>
        <name evidence="4" type="ORF">I206_107054</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC73089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009842.1">
        <property type="nucleotide sequence ID" value="XM_019157124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HZA5"/>
    <dbReference type="STRING" id="1296096.A0A1B9HZA5"/>
    <dbReference type="GeneID" id="30173772"/>
    <dbReference type="KEGG" id="kpin:30173772"/>
    <dbReference type="OrthoDB" id="2565383at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628278" evidence="2">
        <location>
            <begin position="20"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="369"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="404"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF48623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC73089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="471" mass="48277" checksum="45C92E2115D0AFA9" modified="2016-11-02" version="1">MRLIGIIIYAFSILTLSQAISLGRLQSANRRSYEERSPQNDDSASLPPGVELRVGIPLFKNGSIESYEIIERNTPEVPESTGDAAIPTSSSPTSSEGPITITRTHIETKTETPSESTTSSNQPSEVPSPASSTSMSPQESSSIEDCKGACPTSTEDENVPSKTDNAAVPNSSSSAPVSAPSTTSSPEKTEECEDDSPSSTDNAAIPTSSSTPEEDECEGNEDDQQEEDQCDEEEDTPAGTTGNAAIPTTTQPTEGSSGGDSGETGGEGDNEDCEDEKDEGDDCEEEKETSTSSSSSSPTTSPSSSPTTGNAAIPTSSSSSPAPTTSEASVPSSSSAPTTSETVNSTTSETPITTTKLSQPETTENAAVPTSTSTTENPTSSSSKESSSPTSKTKTCDCEKDESTSNSPTPTESPPGEGDAAPSNFPEEVGAVVKSTSIMSGTATPSASAQLSDSESTATSPATSDSGWTWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HZH8</accession>
    <name>A0A1B9HZH8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Uridylate kinase</fullName>
            <shortName evidence="9">UK</shortName>
            <ecNumber evidence="9">2.7.4.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:UMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Deoxycytidylate kinase</fullName>
            <shortName evidence="9">CK</shortName>
            <shortName evidence="9">dCMP kinase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Uridine monophosphate kinase</fullName>
            <shortName evidence="9">UMP kinase</shortName>
            <shortName evidence="9">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_05479</name>
        <name evidence="13" type="ORF">I206_106978</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>UMP + ATP = UDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <text evidence="9">Predominantly cytoplasmic.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.14" evidence="9"/>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC73013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009918.1">
        <property type="nucleotide sequence ID" value="XM_019157200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HZH8"/>
    <dbReference type="STRING" id="1296096.A0A1B9HZH8"/>
    <dbReference type="GeneID" id="30173848"/>
    <dbReference type="KEGG" id="kpin:30173848"/>
    <dbReference type="OrthoDB" id="442176at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019205">
        <property type="term" value="F:nucleobase-containing compound kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016776">
        <property type="term" value="F:phosphotransferase activity, phosphate group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009123">
        <property type="term" value="P:nucleoside monophosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000315">
        <property type="entry name" value="Adenylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03172">
        <property type="entry name" value="Adenylate_kinase_UMP_CMP_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006266">
        <property type="entry name" value="UMP_CMP_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01359">
        <property type="entry name" value="UMP_CMP_kin_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMPbind" evidence="9">
        <location>
            <begin position="96"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="9">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="264"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="76"/>
            <end position="81"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="124"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="164"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCF48699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC73013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="295" mass="32577" checksum="F71C4A5414D32D3C" modified="2016-11-02" version="1">MTVIDKVKSAFTSDSPETTTTSTQSNATPSHTEEKNVPSHPKESNAKSVPETAVLSDKAVFDQNKVTVIFVLGGPGAGKGTQCEKLVNDYKFKHLSAGDLLREERNRPGSTYGELITEYIREGKIVPQEVTIKLLENAMSSTLASPPNTTNEWLNGKGRFLIDGFPRKMDQALKFDESVVKSSFVLFFSTNENILLERLLERGKTSGRDDDNKESIVKRFRTFVETSMPVVDYYRKLGKVVEIDSSPPIDEVYEKVKIEIDQRLNSSSTQTSNTTQSTSTTNASNDAAPILAPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I0S1</accession>
    <name>A0A1B9I0S1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytosine-purine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_04801</name>
        <name evidence="11" type="ORF">I206_105978</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010333.1">
        <property type="nucleotide sequence ID" value="XM_019156531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I0S1"/>
    <dbReference type="STRING" id="1296096.A0A1B9I0S1"/>
    <dbReference type="GeneID" id="30173170"/>
    <dbReference type="KEGG" id="kpin:30173170"/>
    <dbReference type="OrthoDB" id="2116389at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF5">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="307"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF49114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC72019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="538" mass="57526" checksum="7365720FB8BFA8D1" modified="2016-11-02" version="1">MANKSINELEGLALSDRTKDTYPTQADNGLDSSQLPQTNYQYDEEAAAAGRYRKYPNGVVGLAKRGMDVLVEHGVEERGIEPRPEEDRDTLTIWSYLPQTTLWAAFNFNILSFSEGVIGPALFGLNWRASAACVVLFTLASGLPVAYCATNGPKTGMRQMVQARYGLGYFPAMIFGLINCATMIGFMSLTAILAGQCLSLASNSTMSYNVGIVIAALIALILSFVGLRALHVVSLTTFPIMIVVFIALTGLSGSKLHLAVAEAAAEATGVTASGVLGYGASLIGFTITYSALASDFTTSLPAHTPRLPLFLCVYLGLTIPIISITLLGAACQLASYSIASWAEASDIGVPNLIFAISGSGGGARFVMVLFCLSVVANTAPTIYSAGLSGQVAIPFLVKVPRYFLALIVTAIYLPIAIVGASSFYVALENFSSVLSYWTALYIPPTLIEPMVFRNPVSRKTYPIEIWNKIGKLPIGFASIISAICGIPIIVASMSQSWWVGWIARRITTGGDVAFELGAIVVTLVYLPVRYLERKYTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I1T7</accession>
    <name>A0A1B9I1T7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Formin GTPase-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_04037</name>
        <name evidence="4" type="ORF">I206_104382</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010735.1">
        <property type="nucleotide sequence ID" value="XM_019155777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I1T7"/>
    <dbReference type="GeneID" id="30172406"/>
    <dbReference type="KEGG" id="kpin:30172406"/>
    <dbReference type="OrthoDB" id="2155261at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formin GTPase-binding" evidence="2">
        <location>
            <begin position="189"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF49516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC70431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="749" mass="82621" checksum="D212AFE6DC7C39F2" modified="2016-11-02" version="1">MSSVNTPSQHRVNSQQQQQRRPSGSRPPPITTPGMPVRAEQAKAIMQQFPQAPRPSNPSPHPSSSSSPANTHAQGNHHRASMPNPQHHYKSSPIDPRTSRNETRGVPPKSNHASISSRPLPRTSQSSGSGSGSGRYNDSSLKETSRTNIRPGQMGPPRQPSANLAWGHQKEASPKEHLMQQGKGDIKPQMRGPNSEVEMQFEHLLNSLQVPSTVRQKFATVSPDVKSSILLSTFNSNPTILSSLGLPIPSSPQETPKMRKRLSTPLLRKAKSSSEVPSPSNSPQVGKTYDVDGEGFVIVASPDSGVENRGIMSPPLGYGSMRGQSMDNPRSVRSPPASSSRPLSSLFTPSNSNGSVTSLGKSSGKGLGIAMGEQPDSFIQWLAAFKGTDLSMDVGKAKKLRMLLRHENTSWVGQFLEMKGYDLILDRLKDLLDTEWREEQHDDQMLYELLRCIKALSTSEIGKSALRSRFPNPFPALSNLLFSEKKPGDLASRQIIVELWIFLFDLFPPISAPTLVSTPKRQISLDNPNRPSSVRFDEKPALSHLKEPVNIVQEVKGLLLPDLPDPTKDHHEFVTKAHRPRVFKALVGELSDICRDYFWIMCHASNTLWDLSEVDENSVEKPVAPGGATGGVEFEAMNYVTTHFKLLNTLCKHQADQSKDEALKLHENLMSSGMDRILVTLRKASTTYYPTLHLELARYVALLKEICPNGKLPYLIGKMVGSPPGEVRRFDSPPIEAKEWLPMPNGISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I244</accession>
    <name>A0A1B9I244_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pre-mRNA-processing-splicing factor 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_04116</name>
        <name evidence="10" type="ORF">I206_104307</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010813.1">
        <property type="nucleotide sequence ID" value="XM_019155855.1"/>
    </dbReference>
    <dbReference type="STRING" id="1296096.A0A1B9I244"/>
    <dbReference type="GeneID" id="30172485"/>
    <dbReference type="KEGG" id="kpin:30172485"/>
    <dbReference type="OrthoDB" id="1931567at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000393">
        <property type="term" value="P:spliceosomal conformational changes to generate catalytic conformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08056">
        <property type="entry name" value="MPN_PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13838">
        <property type="entry name" value="RNase_H_like_Prp8_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.230:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000002">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1570.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.40">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012591">
        <property type="entry name" value="PRO8NT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012592">
        <property type="entry name" value="PROCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012984">
        <property type="entry name" value="PROCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027652">
        <property type="entry name" value="PRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021983">
        <property type="entry name" value="PRP8_domainIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043173">
        <property type="entry name" value="Prp8_domainIV_fingers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043172">
        <property type="entry name" value="Prp8_domainIV_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019581">
        <property type="entry name" value="Prp8_U5-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042516">
        <property type="entry name" value="Prp8_U5-snRNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019580">
        <property type="entry name" value="Prp8_U6-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019582">
        <property type="entry name" value="RRM_spliceosomal_PrP8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140:SF0">
        <property type="entry name" value="PRE-MRNA-PROCESSING-SPLICING FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08082">
        <property type="entry name" value="PRO8NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08083">
        <property type="entry name" value="PROCN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08084">
        <property type="entry name" value="PROCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12134">
        <property type="entry name" value="PRP8_domainIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10598">
        <property type="entry name" value="RRM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10597">
        <property type="entry name" value="U5_2-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10596">
        <property type="entry name" value="U6-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="JAB1/MPN/MOV34 metalloenzyme" evidence="8">
        <location>
            <begin position="2128"/>
            <end position="2262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCF49594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC70357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="2363" mass="272166" checksum="4AE9EB8D822161C0" modified="2016-11-02" version="1">MSAPPGFGAAPPGFGGSSSQPNGNGESRMDGDFFGQLSQDEIEKKARKWRQSQKRRFDPKRRQGGGGGIDFGKADLPPEHLRKIIKDHGDMSNRKFRNDKRVHLGALKYVPHAVMKLLENIPMPWEQVREVPVLYHISGAITFVNEVPQVIEPVYHAQWASMWLAMRREKRDRRHFKRMRFPPFDDEEPPMDYGDNVLDVEPLEAIQLELDEEDDEAILDWFYDPKPLLDTPHVNGSSYKYFSLSLPQLANLYRIGRQLLSDYSDNNAFYLFDKKSFFTAKSLNIALPGGPKFEPLYRDTEAFDEDWNEFNDINKVIIRGMIRSEYKVAFPHLYNSVPRSVHIGPYHEPKNVYIKTDDPDLPAFYFDPLINPISQRVVQEAHTPLVSHEDAVFGFGNEEDEEFELPDELEPFLENKDLSNDNTADAIALYWAPYPYNLRSGKTKRAQDVPLIKNFYLEHCPPDQPVKIRVSYQKLLKVYVLNALHHKRPKAMSKRNLFRSLKNTKFFQTTNLDWVEAGLQVCRQGYNMLNLLIHRKNLNYLHLDYNLNLKPIKTLTTKERKKSRFGNAFHLCREILRLTKLIVDAHVQFRLGNVDAFQLADGLQYMFAHVGQLTGMYRYKYKLMKQIRMCKDLKHLIYSRFNTGPVGKGPGVGFWAPGWRVWLFFMRGIVPLLERWLGNLLARQFEGRNSKGTAQTVTKQRVESHFDLELRAAIMHDILDMMPESIKANKAKTILQHLSEAWRCWKANIPWKVPGMPAAIENIILRYIKSKSDHYTSVAHYNRERIRRGATVDKAVVRKNLGRLTRLYLKAEQERQNGYLKDGPYISSEEAVAIYTSTVHWLESRKFAPIPFPPLSYKHDTKLLVLALEKLKEAYSVHGRLNQSQREELALVEQAYDNPHECLSRIKRLLLTQRAFKEAGIEFFDTYDKLIPCYDIEPVEKITDAYLDQFLWYEADKRGLFPNWIKPSDNEPPPLLVYKWCQGINNLTDIWDTSDGECVVMMETVLSRVYEKVDFTLLNRLLRLILDHNLADYITAKNNITLTFKDMSHVNAYGMIRGLQFSSFVFQFYGLVLDLLILGLQRASELAGPPGAPNGFLQFRDTETESRHPIRFYTRYVDRIHILFRFSSDEARDLIQRYLSANPDPNNENMHNYNNKRCWPKDCRMRLNKHDVNLGRAVWWNVKSSLPRSLTTIEWEESFVSVYSKDNPQLLFSMSGFEVRILPRIRTQHGEQYSLKDGVWNLTQESTKERTAQAFLRVSDQGVNDFNNRIRQVLMSSGSATFSKIINKWNTALIGLMTYYREAVVHTNELLDSLVKAENKVQTRVKVGLNSKMPSRFPPCVFYSPKELGGLGMLSMGFVLIPQSDLRWSKQTDSGGITHFRSGMTHEEDQLIPNLYRYLQPWEAEFLDSARVWSEYAMKRKEATASNRRLTLEDLEDSWDRGIPRVNTLFQKDRHTLAYDKGWRVRAYFSQYFRLRNQPFIWTNNRHDGKLWNLNSYRVDVIAALGGVEGILEHSLFKGTAFPTWEGLFWEKASGFEESMKYKKLTNAQRSGLSQIPNRRFTMWWSPTINRANVYVGFQVQLDLTGVFMHGKLPTLKISFIQIFRAHLWQKIHESVTMDLCQVFDQELEALQIETVQKETIHPRKSYKMNSSASDILLFSSYKWQISRPSLLTDNRDTFDGTTSNKFWLDIQLRWGDFDSHDIERYARAKFLDYSSDSQSIYPSPTGVLIALDLAYNIYSAYGNYFPGLKPLLQQAMAKIMKANPALYVLRERIRKGLQLYSSEPTEPYLNSSNYSELFSNQIIWFVDDTNVYRVTVHKTFEGNLTTKPINGAIFIFNPRTGQLFLKIIHTSVWAGQKRLGQLAKWKTAEEVAALVRSLPVEEQPKQVIVTRKGMLDPLEVHLLDFPNIVIKGSELQLPFQATLKMEKFGDLILRATQPQMVLFNLYDDWLKSISSYTAFSRLILILRALHVNNEKAKIILRPDRATITESYHIFPSLSDDAWMSVEVALKDLILADFGKRNSVNVASLTASEIRDIILGMEIAAPSVQRQQMAEIEKTTEAQSQVTALQTKTTNIHGDEIVVTTTTNYEQQTFASKSDWRVRAISATNLPLRVNHIFVGNDDVKDDAGAFTYVIPKNVLKTFIVNGDLRTQVVAYLYGSSPADNPQVKEIKAVAWIPQRGSNNGVELPAALPKHDFLLKDLEPLGWIKTQSTELNRLSPSDVTTQAKIMANHSEWGPQSICVTCAFTPGSVSLNAWELSVSGFEWGRKNQDVTGQNPGFNPSMANRVQLLLSDRILGMTLVPEGGIWNYGVGLTQSWSDKLPYSMTLDRPESFWAPCHRPNAFLNFASMEGDDAADVENSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I2E3</accession>
    <name>A0A1B9I2E3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_04244</name>
        <name evidence="3" type="ORF">I206_104181</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Murphy C."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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                <person name="Heitman J."/>
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                <person name="Young S.K."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Chapman S.B."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
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                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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                <person name="Litvintseva A."/>
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                <person name="Young S.K."/>
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                <person name="Gujja S."/>
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                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
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                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
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                <person name="Young S.K."/>
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                <person name="Litvintseva A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="Zeng Q."/>
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                <person name="David-Palma M."/>
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                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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        </source>
    </evidence>
    <sequence length="1252" mass="136967" checksum="136D92A5B68E52BE" modified="2016-11-02" version="1">MSEEDQDDPPRSIASLRSKFENLAAANEFTVVGGVQKASSGGRNGYTSKTSVDLGKISGTTGDVQINGLKPVYVSRPTTPVPSSPPQPVSTKVPPPRPTTPKPLISAHNSDTANNHNVTVASAQAYLEPEPPKEQTRSSTVTPLASPSLPSQLIPSSPKLARRSSHGVPYKPSSAANTPTGSDDGVPNEDPISSVKSLRERFSFGINAEASSSTTSLPRSISAETPRPSAPIMTSKQVSAPTIKSTSTDGQTENSVSVSPENENKTNFISSPQPIKALDVGHRAAPPPPLSRTSSPAPPPPDRSHKPPPRKTSSPIPPPSRGTSSPAMSQEPTSAPPLPQRRATIVVPESPEPTITPPPIPNNKPYISASLLSSTSTSDAGPGPPPPRLPSRSRASTISKPENETIPPSDVQLPPPRLPARTATISSSTFAPPSHPSSPSRSRENTNEILPPPLRSALMNSASLSSSPPSRRRTNSTEKEKEENYSEDEDDDATEDSTPIAGLSATAKKMLEEFPDSTEANRRSPNFKPDLKIRDCHHVTAFATFGRHVCTGAHHVKIYDTQLSEQPISTVDLKETGLEQKSKDPKVTAMCFRPGATMAEEGRYLWCGTKDGHLWELDISTLTVSSTKAFAHTASIAHIFRHRKNIVTLDESGKMLVYDVGDVEGKQPILIRTLRVGEKFTFAKMLCGRLWTSSGPVARSTTSASTSKGPTIRIYDPCSEGNMPPAKVLFTTEWTGAVTSATYIPLEGDKVYLGHEGGFVSIWDMNEFTCLQVLKISTTDILALEGVGDRLWAGNRKGQISVYDVTHRPWLTINQWNGHPDHPIQALVVDPYSIEYSGRYTCWSFARDCMRPWDGLLSVDWIDKQLVTRQADFCTYRDINLLVCSWNIDSAKPTDLTGSEANSKWLEKCLNSVDSPDIIVFGFQEVIPLTDKKITAKTLLFGGKSKDSSSSSSDKVSHAYRHWLEKLTQSVRMAMPSDIPYVKIHSENLVGLFTCIFVKSSQKDSLRALDITTVKRGIGGIYGNKGAIVSRLVMDDTSLCFINVHLAAGQSQKSARNADLAAIMEDKAIFPSAGEEIPFVHGGNGTGILDHELVVLNGDLNYRIDQRRENVISSISAGELSYLLEHDQLRKEMRSNHAFRLRNFEEATINFAPTYKYNPGTDEYDSSEKRRIPAWCDRILYRKSPHMKSINYKRYETNVSDHRPISGGYSITLKAVNSLKEMDVRRELAVEWAEKEKEMLLSMAEKIDSYYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I3U7</accession>
    <name>A0A1B9I3U7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Chromatin remodeling-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I206_03517</name>
        <name evidence="14" type="ORF">I206_105580</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011417.1">
        <property type="nucleotide sequence ID" value="XM_019155263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I3U7"/>
    <dbReference type="STRING" id="1296096.A0A1B9I3U7"/>
    <dbReference type="GeneID" id="30171886"/>
    <dbReference type="KEGG" id="kpin:30171886"/>
    <dbReference type="OrthoDB" id="118550at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02336">
        <property type="entry name" value="ZZ_RSC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000020">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000014">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041984">
        <property type="entry name" value="Rsc8/Ssr1/Ssr2_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032451">
        <property type="entry name" value="SMARCC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802:SF41">
        <property type="entry name" value="BRAHMA ASSOCIATED PROTEIN 155 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802">
        <property type="entry name" value="SWI/SNF COMPLEX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16495">
        <property type="entry name" value="SWIRM-assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIRM" evidence="11">
        <location>
            <begin position="120"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="12">
        <location>
            <begin position="364"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="10">
        <location>
            <begin position="369"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="478"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="579"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="482"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCF50198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WWC71622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="693" mass="75441" checksum="59DCBFAEC184CAF5" modified="2016-11-02" version="1">MSTPKISIKVSTPGGPSVTSPAEPVTADATGGDVVTHDVATAPGKEREREPIYSGEIGNISGVGESSTATAQATQDEPMATSTPGVDGEAPTPAQEVERPTPQQLHDLATTYLAAQTHPLVIPSYSSWFSLSTIHPIERRSLPEFFSSRNRSKTPAIYKDYRDFMLNTYRLNPGEYLTVTACRRNLAGDVGAIMRVHAFLEQWGLINYQVDPDTRPAALGPPFTGHFRVTLDTPKGLSNLVHPGTRPNTGALSLSAQTNGVTPHPSNLDLRKTIYNSTSKSSKPISSGEAVKLVATNGDVQPKTQSFACETCGTDCTRTRYHSAKDGEYTLCPTCFVSGRFPSTMFSGDFVRLDEETFKHSSTGAGAEWSDQETLLLLEGVEMFDDDWQNVSEHVGTRSKEQCIAKFLQLPIEDSYLTSDPTSTDLGPLKYQAGLNGLPFDGSENPVMSVVTFLASTVGPAVAAAAAQSALGELSKGLKRKRGDEQENGERAVKAEKTNGEDTNVEKIIVDGEEVLEGSSEKINGEGEEESNDDVPNTIEVSKVANIALNSAAIKAKKLAKHEDSKISKLISRLINAQVKKIEIKLKIFENLEENLENEKRLLELGKQELFKDKFLIKKQLEKVELLLKQAKENPQQLILNDSSTEKKNLIEEIKIDLNSNNKSTADLIEPVYGITKVPPIPIEEGSNNLQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I4L2</accession>
    <name>A0A1B9I4L2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_03773</name>
        <name evidence="4" type="ORF">I206_105317</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Roberts A."/>
                <person name="Saif S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
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                <person name="Imamovic A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
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                <person name="Birren B."/>
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    <reference evidence="11" key="4">
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            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF50610.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC71202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="339" mass="36962" checksum="D095E0915C57F80A" modified="2016-11-02" version="1">MAASPSASPSLFGDISVDHAVAGFGAGTVATLVMHPLDLVKVRFQLAESSSASSSAYNANSTIPHYVKKPRFGTGVYTALKDAVQVDGWKGLYRGLGPNLVGGAGSWGLYFLFYNMIKKQMQGGDPNYRTSSGQHLLAAAEASAVTAMLTNPIWVVKTRVFGTAKHDPAAYRGLWDGLTSIYRTEGIRGLYKGSLLALVGVSNGSIQFATYEEIKRRRADLKRKRFAKQGREWKTEDEKLSNTEYIMASGSSKLVAIALTYPYQVIRARIQNSTPSLTTPKLTIPSVISSVYKHEGLLAFYKGLGTNALRILPGTCTTFVVYENLVWAFRSLALKRQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I580</accession>
    <name>A0A1B9I580_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_02737</name>
        <name evidence="4" type="ORF">I206_102390</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="OCF50682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019154498.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="30171106"/>
    <dbReference type="KEGG" id="kpin:30171106"/>
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    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037737">
        <property type="entry name" value="Srf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36819">
        <property type="entry name" value="REGULATOR OF PHOSPHOLIPASE D SRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36819:SF1">
        <property type="entry name" value="REGULATOR OF PHOSPHOLIPASE D SRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="713"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="745"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="786"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="877"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="394"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="692"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="42"/>
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        </location>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="OCF50682.1"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I5A8</accession>
    <name>A0A1B9I5A8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_02763</name>
        <name evidence="8" type="ORF">I206_102416</name>
    </gene>
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        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF50707.1"/>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="Mohammad A.W."/>
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                <person name="Litvintseva A."/>
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        <property type="entry name" value="GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106:SF27">
        <property type="entry name" value="MACRO DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Macro domain-like"/>
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    </dbReference>
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        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="26"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF50774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC68550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="213" mass="23069" checksum="F51D3848855341A5" modified="2016-11-02" version="1">MTTSPNDIPTLADLYNSNEISKANDDSKYNYDEALNKRISIWRGDITKLEADVIVNAANSSLLGGGGVDGAIHRAAGSNLLEECKTLGGAKTGETKLTKAYKLPSKFIAHTVGPIYSSSKKEECELNLKSCYSTSLELCKNNGGGSIGFSSISTGVYGYPIQDATEIAIETTRTILEKDETITRVIYVVFSQRDEDVYKSIIPKYFPPSSLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I5L9</accession>
    <name>A0A1B9I5L9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I206_02883</name>
        <name evidence="16" type="ORF">I206_102532</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX48/FAL1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF50826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012045.1">
        <property type="nucleotide sequence ID" value="XM_019154642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I5L9"/>
    <dbReference type="STRING" id="1296096.A0A1B9I5L9"/>
    <dbReference type="GeneID" id="30171252"/>
    <dbReference type="KEGG" id="kpin:30171252"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18045">
        <property type="entry name" value="DEADc_EIF4AIII_DDX48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000498">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="54"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="235"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCF50826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="WWC68602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="396" mass="44780" checksum="5B512057861BF0C3" modified="2016-11-02" version="1">MAGINAGDEKLVFESSEAVSVAPTFEALNLKEDLLRGIYAYNFEKPSAIQQRAIIPIMRGRDVIAQAQSGTGKTATFSISALQSIDTKIRETQVLVLSPTRELAIQIQTVVLALGDYMNVSCHACIGGTSVGEDIRKLEAGQQVVSGTPGRVFDMIRRRNLRTKDIKMLILDESDELLNKGFKDQIYDIYRYLPPATQVVVVSATLPHDVLEMTTKFMTDPVRILVKRDELTLEGIKQFFVAVEKEDWKFDTLCDLYDTLTITQAVIFCNTRRKVDWLTEKMREANFTVSSMHGEMVQKERDAIMAEFRGGQSRVLITTDVWARGIDVQQVSLVINYDLPTSRENYLHRIGRSGRFGRKGVAINFVTVEDVRILRDIEQYYSTQIDEMPMNVTELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I6B5</accession>
    <name>A0A1B9I6B5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_03128</name>
        <name evidence="7" type="ORF">I206_102773</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
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        <name evidence="6" type="ORF">I206_102815</name>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
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                <person name="Pearson M."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
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    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF51103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012322.1">
        <property type="nucleotide sequence ID" value="XM_019154919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I6F3"/>
    <dbReference type="STRING" id="1296096.A0A1B9I6F3"/>
    <dbReference type="GeneID" id="30171538"/>
    <dbReference type="KEGG" id="kpin:30171538"/>
    <dbReference type="OrthoDB" id="1740265at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033934">
        <property type="term" value="F:glucan 1,4-alpha-maltotriohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004574">
        <property type="term" value="F:oligo-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000025">
        <property type="term" value="P:maltose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11332">
        <property type="entry name" value="AmyAc_OligoGlu_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000001">
        <property type="entry name" value="Maltase A3, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF179">
        <property type="entry name" value="NEUTRAL AND BASIC AMINO ACID TRANSPORT PROTEIN RBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="4">
        <location>
            <begin position="15"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF51103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC68879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="560" mass="63273" checksum="D2F9E9933133B2CD" modified="2016-11-02" version="1">MSKDPNWWRQAVIYQIYPRSFADANGDGIGDLKGITSRVPYLKQLGIDAVWLSPFYPSALKDGGYDVADYRDVDPKIGTLEDFDEMSAALKNAGIRVMVDIVPNHSSDDHEWFQAALKAGKGSAERERYIFRDGKGANKDEPPTDWNCIFGGSAWSPSGSNDGQWYFHWFDNSQPDFNWEHPDVKADFLKTLKFWGDRGVSGFRIDVAHGLAKDMSEPLPDWETLDKMTTQKLTNGNADLDHPLLDRQEVHEIYSSWRKLFNQYDPPLMAVAEAWVAPDRKPLYASADGLGQTFSFDILLCNFESEEYRKCINDSLAAAEETKSSNTWVLSNHDVMRHATRFGLPNVPNENLPVSQVALNKFLIDRFQTQKVDVESGIKRAKAATLLILALPGSTYIYQGEELGLQEVVEIEPEERQDPIFRRTKGKEIGRDGCRVPLPWSSNDKNFGYGPGKPAHLPQPDWMSNYAVDKEDEDPKSTLNVYRRALELRKRLQTSETFEWVKNPEKDILHFKRPGGWEVVINFSKNEAALPAGKVLVSSSEQSVKEGVIAGETTVWLESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I6F5</accession>
    <name>A0A1B9I6F5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_03176</name>
        <name evidence="12" type="ORF">I206_102822</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF51110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012329.1">
        <property type="nucleotide sequence ID" value="XM_019154926.1"/>
    </dbReference>
    <dbReference type="STRING" id="1296096.A0A1B9I6F5"/>
    <dbReference type="GeneID" id="30171545"/>
    <dbReference type="KEGG" id="kpin:30171545"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002930">
        <property type="entry name" value="ABC transporter family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF91">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="595"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="629"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="671"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="704"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="741"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="817"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1220"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1258"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1297"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1331"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1361"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1449"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="223"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="876"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="65"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCF51110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC68886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1476" mass="162204" checksum="5FD0B7C4D66D5A30" modified="2016-11-02" version="1">MSLQSQGERDDDEEAGPSRTNIPILGQPINLNITKTDIEPRTSIGRNAQTEVRHVNDDQNVESSIGKRDVKGNELLGERSQVDLVDQKDRMNSENTHLTDEQDSTHTGQKNNGIEGDEEVEMKEVQTQRQPRSHIPPNIPTRISSNAQTLPISVKPDPAEKPVNPQFERMRSEDPMERIRSNDVNALLNLPPPLPFHLSVEGLTIGVPDKKVPAWIPKLPKYFKRDNKEIVPPIGEEKPKKKWILKEVGCECRSGEMLAILGGSGSGKTTLLNAIANRLSGLPTETGQVAYYSANSHTSTNQTAVKGQKLGRSEMKRRIGFVRQQDYLVECLTVRETLTYAAKLRLPTSLSDEAITHIVNQTIDELGLRDAADTVVGGPLRKGISGGEKRRLSIGCVLVTLPSVLILDEPTSGLDAFTSYLLLLTLSHLARRGRTVILSIHAPRSDAFDIFDRIALLSKGQIVYSGLRNECLGWFSGLGENVEKGVNPLDFLIDISTIDNRTTEAEETSRERVSALVGAWKNRSPTVNNRLSKTSIDSTASSVHVRPDGIAASKEGNDDIEKLVAKDEKRPGLVKQTIVLTARAHRNVYRNVPQLVGFAVQAVVLGVIIGVTYYRLPETPTGIQSLKNLSFQLIPGVFYLQQVFWIYKFCTDLIIFDREREDVTPYVISDFISYLLPSVLSPTIYVVLVYFISRLRTEDLAARLFTSIASTILVQFATQGLSLVSSSLLRSFAAASLVGNALNLFMIMSSGFIVVHVPAYVAWIRWLSPYFYSFRIIATTQFKDRVFDCPPDSAANLNQCVGNNVLNGLNFDASVNIGAWFGGLIGVTILEYTLACFILWIYPAGGVKHASEIESHNRGKGTDVMESNMTRDKIEVAVKNLTLRWERKGRGAVKDKQKTILNEISIHFPAGEISAILGPSGAGKSTLLQLIAGRPLNPGPFSRFTHSGSLLFAGEAASSASRSNVAFVEQDDDWHLPSLTVRETLTYAAILRLPDKMPRRQKVARAETVLRMLGLKDCADLPVGGQLLKGISGGEKRRLSLAVQMINDPAVLVVDEPTSGLDASIALSVMQVLRDIAATGRTVIATIHQPRSDIWKLADNVTLLAKGGVVAFNGRRSEAVDYFTKIDLPMPSEFFNPADHLLDLVSVDPRPQEYESSLSRVKDLTLRWSTHVNNEDGGENEKAKSTQVLTRGEGTTSMRVALPVVLERHWKNLWRRKDIFFNRLVQTPLLGGMFILFFQRLNHGPSGAQDRIGITIESTSAIAFVGLLNAMAIFPADRNLYLHEAKSSARYSPATFVITYTLVELGFEIAGAIGYAAIMNIGVGMQTSVRIYFEFAVTIWAMVNMGESFAMIFGSWIQTEGLTVTVVSTFLSMIGQVSGVISLSVPTWLAALAWGTCVKAATRIQIINESVGLVFNCTPDEISSGTCVAQSGEQLLALFGWKDLNTGRFMGILIAVAVGWRIIAWLSLAGRVGGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I6R1</accession>
    <name>A0A1B9I6R1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_03227</name>
        <name evidence="3" type="ORF">I206_102877</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF51161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012380.1">
        <property type="nucleotide sequence ID" value="XM_019154977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I6R1"/>
    <dbReference type="GeneID" id="30171596"/>
    <dbReference type="KEGG" id="kpin:30171596"/>
    <dbReference type="OrthoDB" id="2564489at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF51161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC68941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="395" mass="43747" checksum="0215B634DBEF1F3E" modified="2016-11-02" version="1">MSASWHTNDHTPSGRGLSVPLRRTGSVTRSRSTLTPSVNSKRSSAFLNTSSNVEFGVTSPGVASDLMNESAGLRKTIEGLNKTNLSLRSRIAELETHIDHNTGPEVVKLNKELATLEDLFASSQKANEAQYAESERQKGYVKELENLLTTSLGSDWQESHKLYPPLAPTTIVTASTPLPPPKAVNTLRHSISFNAKRSSKKLDRRASSVMDLGLVGLQAVQEENRNPDDTPTGALWKLSGSIKPAHERLEEKVLCASPQPGPSTLLCSTKAQEDSMAHSSSDAQTLSGIDVNQLNQVLQMLSGLNPTKLTDLVSRNQSVSKSPDSSADNSRRERNDHIRTVRRILESQQKMLEERETRLRDILEMVSLVISNQCVWLVDTAIWRDRRKKRRQNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I6V4</accession>
    <name>A0A1B9I6V4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytosine-purine permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_03342</name>
        <name evidence="12" type="ORF">I206_102989</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF51275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC69053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012494.1">
        <property type="nucleotide sequence ID" value="XM_019155091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I6V4"/>
    <dbReference type="STRING" id="1296096.A0A1B9I6V4"/>
    <dbReference type="GeneID" id="30171711"/>
    <dbReference type="KEGG" id="kpin:30171711"/>
    <dbReference type="OrthoDB" id="2116389at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015851">
        <property type="term" value="P:nucleobase transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000002">
        <property type="entry name" value="Purine-cytosine permease fcyB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF1">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="346"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="464"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCF51275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC69053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="529" mass="58112" checksum="8724C33680A66110" modified="2016-11-02" version="1">MVEQSSSEWDDKNYHSSIRRPDDLNYDVQPLDEEAALGEDEVAHRNPIFRKLSGLFNKGVEARGIERVPEEERDGKHTIGLLLLWWSVNMVVSTLPIGLLAQAYYTLTFHSAVAAIVVFTALGAAFTAFIATLGPKTGLRTMVITRYSVGYVGATIFSFLNILTQLGFSVTAIILGGQTLTNVSNDKLPLEASIVIVGVLALVLCFVGYEAMHYWERYAWILLFIFYCCMWGLAGHKGFDMGAQQALQDTGKSYAGDFLSFGGIVFSSASGWAPVAADFNCRLPSNIRPWKVFMLTWFGLMVPLLFVEILSAALMTVPAYAQAFEDGDAGGVLAAVFEPWGGGGKFILVVFAFSIISNCIPNTYSAALSCQCLLPAFQKIPRALWTILVFVIYTVAAVAGREHFSEILSNFLAILGYWVAFFVVVVFEEHYIFRYWFHKQGINSSGPARGYDLTAYDNWRRLPVGAAGIFACCCGVGAAVVSMAQVWYIGPLGAVFGEFGGDLGFEMSAVVTAIVFPPLRYLEYRLIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I6Y0</accession>
    <name>A0A1B9I6Y0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Squalene monooxygenase</fullName>
            <ecNumber evidence="14">1.14.14.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">I206_02006</name>
        <name evidence="18" type="ORF">I206_104476</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>squalene + reduced [NADPH--hemoprotein reductase] + O2 = (S)-2,3-epoxysqualene + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25282"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:15441"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 14">Endoplasmic reticulum membrane</location>
            <topology evidence="3 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the squalene monooxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.17" evidence="14"/>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012511.1">
        <property type="nucleotide sequence ID" value="XM_019153771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I6Y0"/>
    <dbReference type="STRING" id="1296096.A0A1B9I6Y0"/>
    <dbReference type="GeneID" id="30170375"/>
    <dbReference type="KEGG" id="kpin:30170375"/>
    <dbReference type="OrthoDB" id="1678617at2759"/>
    <dbReference type="UniPathway" id="UPA00767">
        <property type="reaction ID" value="UER00752"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004506">
        <property type="term" value="F:squalene monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000166">
        <property type="entry name" value="Squalene monooxygenase Erg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013698">
        <property type="entry name" value="Squalene_epoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040125">
        <property type="entry name" value="Squalene_monox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835:SF0">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08491">
        <property type="entry name" value="SE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 14" id="KW-0274">FAD</keyword>
    <keyword evidence="5 14" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="17" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="11 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="474"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="513"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="15">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene epoxidase" evidence="16">
        <location>
            <begin position="215"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OCF51292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="WWC70525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="544" mass="58976" checksum="D03381BCBF5A7BCC" modified="2016-11-02" version="1">MSTTPDIQVASSGIDHVSIHSLQPEIIIIGAGVVGCALAYSLSQSGREVVVLERDLTEPDRIVGELLQPGGVAALEALGMADVLEGIDAVPVEGYCIVSGEDQVGCPYPLLEEMAGLNKGEKSDELDGAWIDKKGKWHIESNSGKKEGRSFHHGKLISSLRKKILNVKGVTVLEATVKDLVFCEHTNRVIGISASFKTAESDEITSSGIVKKIYAPITIIADGCFSKFRLTPGMRTPKPVTRSHFVGIILDDCKLPIKNMGTVCLTPSGPVLLYQIGNAKGEVRMLVDVKGKLPSVGDGSLRRHIEEQYVPHLPSSLQPSVISSLATQRLRSMPNTFLPPAIQGLNNHLSGAILVGDAYNMRHPLTGGGMTVAFNDALILSKYLKPSETLPKGRQGLEDWNEISEVLKKWFWERKQLSGVVNVLSMALYSLFGGADEPELEVLREGCVKYLGMGGEKVAGPVGLLSALTPAPFMLFYHFFSVAFYSIFLLLVRGPPNSSLRTTNGALNPLMVLLTLPLNLIYSIKVFWTACVVLLPVIYTEFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I6Y4</accession>
    <name>A0A1B9I6Y4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_03321</name>
        <name evidence="3" type="ORF">I206_102969</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">CBS 10737</strain>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1B9I7J8_9TREE</name>
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        </recommendedName>
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        <name evidence="13" type="ORF">I206_02251</name>
        <name evidence="14" type="ORF">I206_104713</name>
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        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
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    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
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        <subcellularLocation>
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    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosyl-DNA phosphodiesterase family.</text>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0017005">
        <property type="term" value="F:3'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="UIM_dom"/>
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        <property type="entry name" value="Tyr-DNA_phospho"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="96"/>
            <end position="293"/>
        </location>
    </feature>
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        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
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        <ligand>
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            <position position="689"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCF51537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WWC70762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="754" mass="84375" checksum="7064F4F3AC47CD07" modified="2016-11-02" version="1">MDEDEVASILGESSLNLATSARPTVPQRGENRAFDRYFDESTRHHDPSEVDFQELRRAAWATWKINPPAALSGNTRENDNDDDELARVLALSVQEHFSRPTSRQPSVGIVDDEEDEDLKRAIAMSQEEARAPKRRKREETPEEERKMLAEAMAASLAETGSTSAVSSTNPTESSSLSTNEQSEVAKSATPMQETESVPTPGLRIGGQIIDRAQLERERRERQAARQAASTPASDTPTPNASSANTRPQAGPSRIAGMSSISSGPTAGPSTPRANSSPKHPLQSEGSFPSDAAGEYYPYGELRHVALTIAEPTTERTFSPKQVIGTHSQISLIIMSSFVIDDQWIMDKGILPPPEDVPTIVVRPHPKDKQEYNGKIQSYPNGEIWVYPKMINYHGSAHMKYFWIFYKTGRLRIVISTANMVDYDWAMIENTIFVQDFLPLPTPRPLRPDNDTHDFPLQFAQLFKHTRIHTALRSMLHTHPKASEINFKPDDDFAAMGKYDWSKVKVRLVLSIPGTYSGHDEIAKYGIARLGKVLSEEGWVPKSGEKLDVEYQGSSLGEFKIDWFDKFNSFLHGKTSRDLMNRPKPVEWPNIRILFPTLANVEQTILGKAGGGTMFCGKAFKEHIRHLFRDSRSKRGGVLMHTKMLVATFEPQENRLGVEKSTPMKSVKRKADEMKDDVGGWVYVGSHNFSIAAWGTVDVKKNPPTCTIKNYEIGIVFPLERGTARAIADKIAPYKRPAVRYTAGDVPWDQYAHRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I7Z0</accession>
    <name>A0A1B9I7Z0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Coatomer subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">I206_02362</name>
        <name evidence="19" type="ORF">I206_104823</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Oligomeric complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Golgi apparatus membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Cytoplasmic vesicle</location>
            <location evidence="13">COPI-coated vesicle membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the COPG family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012866.1">
        <property type="nucleotide sequence ID" value="XM_019154126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I7Z0"/>
    <dbReference type="STRING" id="1296096.A0A1B9I7Z0"/>
    <dbReference type="GeneID" id="30170731"/>
    <dbReference type="KEGG" id="kpin:30170731"/>
    <dbReference type="OrthoDB" id="1074925at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000046">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000071">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1480:FF:000001">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000008">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1480">
        <property type="entry name" value="Coatomer, gamma subunit, appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032154">
        <property type="entry name" value="Coatomer_g_Cpla"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017106">
        <property type="entry name" value="Coatomer_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013040">
        <property type="entry name" value="Coatomer_gsu_app_Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037067">
        <property type="entry name" value="Coatomer_gsu_app_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261:SF0">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16381">
        <property type="entry name" value="Coatomer_g_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08752">
        <property type="entry name" value="COP-gamma_platf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037093">
        <property type="entry name" value="Coatomer_gamma_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 13" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="15">
        <location>
            <begin position="18"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer gamma subunit appendage Ig-like subdomain" evidence="16">
        <location>
            <begin position="654"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer subunit gamma C-terminal" evidence="17">
        <location>
            <begin position="806"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="626"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR037093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OCF51647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="WWC70871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="924" mass="101661" checksum="D357601236A902E3" modified="2016-11-02" version="1">MSFKKDEEAGGMSFYHDKSTILQEARCFNESPISPRKCRALLTRIVYLLYVGETFSTQEATTLFFGVTKLFQHKDAALRQMVYLVIKELSTIAEDVIMVTSSIMKDMQPNLEVVYRPNAIRALARIIDSQSVQSVERFFKSALVDKSSSISSASLVSSYHLFPLSPSIIKRWSNEAQEAVNAKSVSSFSSNASAYLSGGQSGGYQAVASSSYIMQYHALGLLYLIREKDRMAITKMVQQLGSGSKGSGIIKNPMAMCMLIRFARKVMDEDPNVRKQMHEYLETLLRHKSEMVNIEAARAICEMRDVQPGDLYRTVAVLQLFMNSPKPVIKFAAVKTLNKLAQILPQSVATVNVELENLITDSNRSIATYAITTLLKTGNEASVDRLMKQISSFMADITDEFKIIVVDAIRSLCLKFPAKQAIMLSFLSGVLRDEGGYDFKHAVVEAIFDMIKFIKDCRETALAHLCEFIEDCEFTKLSVRILHLLGIEGPKTRNPTKFIRYIYNRVVLENAVVRAAAVSSLAKFGVCIDDKTVMKSVNVLLRRCLDDVDDEVRDRAAMYIKVLEEKSLADVFVREEATFSLAQLEEQLVSYVKDDTKHSAAFDVSSIPRVSKEAAAAEIAHNRPSALDIAGPSSSRAAEPTPQASSSAEGQASSYAAQLAAVPELESYGPVLRSSSKPVELTESETEYVVSAVKHIYKEHIVFQFNVSNTIPDTVLEQVAVIMTPSPDSGLTEDFIVPIDSLNAASSGSGAIYVSFTRDDPSTYAAGTFGCTLKFVSKEIDPNSGEPEEEGYDDEYQVEELDLGAGDYITPTYVTFSSEWDKLSNSANLTETFALSSSESLKDACKSLIEVLNMLPLGGTETPSSNSVHTLNLSGLVIPTNNSEKSTKVLARCRMTYSPGNGVTLELSVRAENEQGAKLVMAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I863</accession>
    <name>A0A1B9I863_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fungal specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_02399</name>
        <name evidence="11" type="ORF">I206_104859</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">CBS 10737</strain>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">CBS 10737</strain>
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    <reference evidence="13" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="13">CBS 10737</strain>
        </source>
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    <reference evidence="12" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.1" evidence="4"/>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC71009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013004.1">
        <property type="nucleotide sequence ID" value="XM_019154264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I8C7"/>
    <dbReference type="STRING" id="1296096.A0A1B9I8C7"/>
    <dbReference type="GeneID" id="30170870"/>
    <dbReference type="KEGG" id="kpin:30170870"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004123">
        <property type="term" value="F:cystathionine gamma-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019343">
        <property type="term" value="P:cysteine biosynthetic process via cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF15">
        <property type="entry name" value="CYSTATHIONINE GAMMA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="5 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="451"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCF51785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC71009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="484" mass="53116" checksum="7FF2D658D0D58F60" modified="2016-11-02" version="1">MPRHDHFSTRSIHVGSEPDPSTGAVVPSLSVATTFRQEGVSKPLRGFDYSRSSNPTRSDLESLLTSLETCPSATVANDARHDASGGESLVFASGSAATAAIAHWVTLNKEEGGAGGKDGKGFGGHILAVNDVYGGTARYLSRASRPTGLEVTYLNMEKAGEKGIREAIRPDTKLIWLELPTNPLLLVPPVRLISDIVHSLPSETRPLILVDSTFLSPYYFTPLIPTNGEHPLADITMSSLSKYSSGHSDIILGSLTISPTTNKLRPELIKGLRFLQNSMGASPSPRDCHLMIRSIKTLSVRMIKHGLNALRISNWLSTKTNLIEKVRYPGLKTDNAFEYVQDLISKNAKRELEFLGWKFPFNKENKDFDIDVDETNLEFTRNLGIPFGGMITFTIKNANSKQVEKFCTELRISILAESLGGVESLIEVPYGMTHAHLPQETLNELNITPNLIRLSVGIEDYEDLIEDLEQALEIAMGTEKATVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I8U1</accession>
    <name>A0A1B9I8U1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-oxoadipate dioxygenase/decarboxylase</fullName>
            <ecNumber evidence="6">1.13.11.93</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2-hydroxyglutarate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_02652</name>
        <name evidence="10" type="ORF">I206_105111</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 2-oxoadipate dioxygenase/decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.93" evidence="6"/>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC71158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013155.1">
        <property type="nucleotide sequence ID" value="XM_019154415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I8U1"/>
    <dbReference type="STRING" id="1296096.A0A1B9I8U1"/>
    <dbReference type="GeneID" id="30171021"/>
    <dbReference type="KEGG" id="kpin:30171021"/>
    <dbReference type="OrthoDB" id="8300246at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16348">
        <property type="entry name" value="VOC_YdcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.80">
        <property type="entry name" value="Uncharacterised protein PF07063, DUF1338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009770">
        <property type="entry name" value="HGLS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047869">
        <property type="entry name" value="YdcJ_bac-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39479">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39479:SF2">
        <property type="entry name" value="2-OXOADIPATE DIOXYGENASE_DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07063">
        <property type="entry name" value="HGLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01150">
        <property type="entry name" value="DUF1338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCF51936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC71158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="460" mass="53064" checksum="3879735E2B844E52" modified="2016-11-02" version="1">MIAQPFVSPDDIRASFCTALSNMYKEEVPLYGDLVELVNDVNKEIKKIKPDLWEIGDRLNVERHGAIRLGTLEELKIISRLFKQMGMFPIGYYDLTKLGIPIHSTAFRPKNNNSLEKNPFRIFTSLLRIDLIKKKNFKLFKEINEILLKRNFFFNNPIILKLIEKSENQGGLILEDSIELINFSLEIFKWHEKSLISKKKYDELKKFHPLLADIVGFKGPHINHLTPRTLDIDSVQRLMSERGIPPKKVIEGPPIRECPILLRQTSFQALTEPIIFSGDCEGETSQGSHRARFGEIESRGAALTREGHALYQSLMKKAGSFTPTDNNLIWQSKLSKIFQPFPDNWEDIRKANLAYFKYTLTSSYEKGTIQSEYSLDQLIKQGKVKYIPIVYEDFLPASAAGIFQSNLGEHSEETIKEEDLNAREEMELSLGHKIQDYFELYEEIQNDSLREIQRLTGCRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I978</accession>
    <name>A0A1B9I978_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_01433</name>
        <name evidence="2" type="ORF">I206_103563</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
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                <person name="Berlin A.M."/>
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                <person name="Imamovic A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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            <strain evidence="5">CBS 10737</strain>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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            <strain evidence="6">CBS 10737</strain>
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    </reference>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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            <strain evidence="5">CBS 10737</strain>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="6">CBS 10737</strain>
        </source>
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        <property type="entry name" value="SSU_processome_Utp14"/>
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        <property type="match status" value="1"/>
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            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">CBS 10737</strain>
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    <reference evidence="3" key="2">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019153328.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A1B9I9V2"/>
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        <property type="component" value="Chromosome 4"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
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            <end position="515"/>
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            <begin position="461"/>
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            <begin position="622"/>
            <end position="632"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF52270.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC69499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="632" mass="68619" checksum="7CC36AAD44ACD16F" modified="2016-11-02" version="1">MTRRNPPSTITLLLPSPSSSSTSLIASSSTLPKSTNKIILPPVPDLEVLILAKKIALEKGQKFDLEAYLNDDQLEEYRTKYLKLPPKPPIIIPPTPPLINQQLQSEEVTPGPSTPTIEIEINTPINGNPSTPNNVETINNNNTPIKKIIKIPDLSHLHWKQRAKRIAELTKEAEMIANGELPESSSSLFNQIDEVNTINQSGGKKGELTDKDKEVIRGSASYWNSLLISARKSRGPQWDYSLQQFQYDRSSSEYYNHGKDPRPADQQSSIKPTPQSTKAELDGEGDEQEMDAENEIDGGSPKKKRKLSLVEKDKPNGLSMNKVDDKGEHENENENGKRIKSNSISQTPGTIPHSLPKQSPHQNHQPTPSANRNDLPSTTPQSNSINLPPQSRISSQVQPSGQTPTPHIQPSQLFGGIGMGRPSLPQNSSSSSSSSIPQSNQNQSNSALLGHGQGGQNVNPNFLASLQQFQQQQQANLQQQQQTQSSSSNQNSQTSIPSTLGGFGGLNPSQLSGLTGLNQQQLNGLNSNQLMGLSNMIQSMNPQFLQQQQQQQQMLINGGGGGNINGLGQQFNNVQQGMSQHGINQNLGMNNVNMTMFQNLNNSGTGSVNGSGNGPMLGGTTPGNNWSEFTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IAH5</accession>
    <name>A0A1B9IAH5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_01901</name>
        <name evidence="13" type="ORF">I206_103095</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC69159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013827.1">
        <property type="nucleotide sequence ID" value="XM_019153666.1"/>
    </dbReference>
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    <dbReference type="STRING" id="1296096.A0A1B9IAH5"/>
    <dbReference type="GeneID" id="30170270"/>
    <dbReference type="KEGG" id="kpin:30170270"/>
    <dbReference type="OrthoDB" id="432483at2759"/>
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        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05574">
        <property type="entry name" value="STKc_phototropin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001236">
        <property type="entry name" value="AGC/RSK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Serine/threonine-protein kinase nrc-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45637">
        <property type="entry name" value="FLIPPASE KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="477"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
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        </location>
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    </feature>
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            <end position="86"/>
        </location>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="833"/>
            <end position="851"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCF52608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC69159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="879" mass="93598" checksum="598C16E96FAEE88B" modified="2016-11-02" version="1">MSAIASPQPPQTPYAPSSLSASTSTTASDTRYTPTSMPSPGPGPSSASGSSKWKNVFKIGRNGASIGKGKEGRPAIPEAERIHLGEPLHLPQSSKFPTRIPQIRSQTDPYPPTQAGIIEEVDSIRPKDPSQEGAISNDSLHINPESNLVTPTSDEQSRPYSSVTDGSGFTADNSSRSSGSRNLTGVVNGHGITTPFGNPASPMKSPGIGLSGFKSRFFSSPNPHPIDTSSSRGKSKADKYKGLGKESSSFTNSHGHKVSVGSSSISSTTGRSPSSSTSPKTPNRTKGRDATGGQATPSDGTGLTTGKTGPGSGSATARFLRRVVSAPNTKALFAPNNLFNDAPDVPPLPATAKDKTAQQPISPVVVVGNGEIDLTASPPRAQNGMSSPFTTPTSSLSAKQSSGPVSGLSATGTRSTRAHTTSAAAQFKNIRDLQAQLGVGSSPGSPSGDPHHKQVFRRTYSSNSIKTKSVEVTPSSFQKIKLLGKGDVGKVYLVKEKKTDKLFAMKVLSKKEMIKRNKIKRALAEQEILATANHPFIVTLFHSFQSQDYLFFVLDYCMGGEFFRALQTRPGKCLSEEHAKFYAAEVTAALEYLHLNGYIYRDLKPENILLHQSGHIMLSDFDLSKQSGEAGGAPAGIKHGGPNGTILVDTRSCIADFRTNSFVGTEEYIAPEVIKGHSHSSAVDWWTLGILVYEMIFATTPFKGPNRNATFANVMKNDVFYPESPPVSSSCKSFIRKLLIKDENKRLGSGSGASEVKSHKWFGTVNWGLLRNMTPPIIPAESNGIDAINFRTLRESKSVDFDRDDVDVIHAKAGNPSVFGNSTPGMLTPKEITTSAETPSSSSISGSVTSNGNGGMNSKDKEKNPFEEFSSVTRHVGEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IB00</accession>
    <name>A0A1B9IB00_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_01873</name>
        <name evidence="3" type="ORF">I206_103123</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013799.1">
        <property type="nucleotide sequence ID" value="XM_019153638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IB00"/>
    <dbReference type="GeneID" id="30170242"/>
    <dbReference type="KEGG" id="kpin:30170242"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF52580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC69187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="301" mass="34593" checksum="DC9E3E341BEEA2B6" modified="2016-11-02" version="1">MPGSTNKHKFSRLFGRKRNNTSQDTDNTSRDLGDPTPVREPNRTTGRLGNPQSINSGTPPNSSNSVALLPPVGHYPNSNSFAIPPLTGYSTDPHQPEQATSSEVQSTEPEATIESRSERRLSVPMKDIYTWREVTGAFEAYIKDMKNIPDEFDKEWYDRDINQELWRQQGKNPEAWRDDIGRIRFELESASFPSSTRYKEERDKHIAVKRSRDLASHIWDTLDIGCRKPEFSPEIAQGALTFFAPILRELIISSTRDRYRLSEADGMWRDDFVRSVRLCNGWWEDGDEESKPVPEERFSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IB74</accession>
    <name>A0A1B9IB74_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Vesicular-fusion protein SEC18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I206_00206</name>
        <name evidence="17" type="ORF">I206_101120</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF52905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014124.1">
        <property type="nucleotide sequence ID" value="XM_019151986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IB74"/>
    <dbReference type="STRING" id="1296096.A0A1B9IB74"/>
    <dbReference type="GeneID" id="30168575"/>
    <dbReference type="KEGG" id="kpin:30168575"/>
    <dbReference type="OrthoDB" id="9982946at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19504">
        <property type="entry name" value="RecA-like_NSF-SEC18_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000026">
        <property type="entry name" value="vesicle-fusing ATPase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000166">
        <property type="entry name" value="vesicle-fusing ATPase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000012">
        <property type="entry name" value="Vesicle-fusing ATPase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000187">
        <property type="entry name" value="Vesicular-fusion ATPase SEC18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039812">
        <property type="entry name" value="Vesicle-fus_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078:SF3">
        <property type="entry name" value="VESICLE-FUSING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078">
        <property type="entry name" value="VESICULAR-FUSION PROTEIN NSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <sequence length="862" mass="94094" checksum="C138684DF2CA5046" modified="2016-11-02" version="1">MSFFKRSDPNAPAARRAGGGVGGPTTGVGNNGPYERLPADNGSYSSLPPSGTQQPGLPPRQPQSQQRDQYVGQDYGRSSPYQDSRNQNQPPLPPRNAGPGINEGYYQEKADYRNQPQQPQQRSYPQQPTSGGGGDGGRGMYNIAPCPSDPLALTNRLVVNPNDFSQDVEFALMRNKYIFSIIRDPTHTLPPRHVGPSKIIRQWVGLSAVGETVDLEPYHPGNGDWASTVEMEVGFRLKRKETSDLFDSEDMAAAFINAFPSLPLTPLQPLVFDYRGHELKATVRAVSTLGGHDGGTGIIMEGTEIIWVKDPTSGIKLKNSSKRGPTNAILAPNFKFEDMGIGGLDTEFAAIFRRAFASRIFPPGLVDKLGIQHVKGILLFGPPGTGKTLMARQIGKMLNAREPKVVNGPEILNKFVGQSEENIRKLFADAEKEQKEKGDESGLHIIIFDELDAICKQRGSTNSGTGVGDSVVNQLLSKMDGVDQLNNVLIIGMTNRMDMIDEALLRPGRLEVHIEISLPDEAGRFQILNIHTSKMRNNGVMADDVDLAELAALTKNFSGAELGGLTKSATSFAFNRHVKVGTVASFEEVENIKISRADFMHALDEVQAAFGVSEEELQQVVQNGIIHYSQRVNDVLNDGSLLVEQVRKSERTPLVSALLHGPSGAGKTALAATIAMASDFPFIKLISPESMVGYSEPQKIAQLHKIFSDSYKSPLSVIVVDNIERLLDWNPIGPRFANGVLQALVVLFGKRPPKDRRLLILATTSNRSILSDMDVMSTFDTDIPISPITNLEGIDHCLREVKLFQSSKDHQKLLSILQNSTIGSKEEGISIGVKKLLTLAEMSRQDPDPVNKLASSLIREIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1B9IBD0_9TREE</name>
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        <recommendedName>
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            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
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                <person name="Imamovic A."/>
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                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
        </source>
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    <sequence length="256" mass="29105" checksum="BD9357160BAC38F8" modified="2016-11-02" version="1">MVTSDNQTPQIDRNIENYSIKIGDDGEPYIPLDGFPDIKLTQWRISDIDDLIELYNQPSVSKYAVNRPIPFEKENAAFLYQEIPIHQIYLQQLINNLPNPPSLENYPKGEISPFGVIRLTSSPSSSSSSNRLNTQGKLIGTLHIRPSTYSPQNWEISYYIHPKYTSKGIGKETIKQGLNFMKWLNIKRIIAFTAKENIASNSVLLKNGFSLYSTHIIDWPEFLGGGKKDVCSWDKYLIPFKGKGPHIVEDPLAVYL</sequence>
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                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Abouelleil A."/>
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                <person name="Griggs A."/>
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                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 10737</strain>
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    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
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    </evidence>
    <sequence length="610" mass="65459" checksum="6ACA2C867FCAD7DE" modified="2016-11-02" version="1">MSFEPPPRRTAASLTPASGSTTPNEDAPGWKEKMKARGSVWGKIAMVKGVKISDNIGGRVNDIAEKRFGTEAFWPVTGDFPKEMEKCARILRAFTVDGIVTEEKEKPDDSATDDKDKKKKKKIKVIRKIPPAVIASATGLAIFTSMRTGFAPFGGAGGAGIVVAKLPDGTWSAPASISPNNLSAGFLIGVDVYDCVLVIRTQEALDSFKTHKVTIGAELAVAAGPYGAGAAVEAGKERAPLFSYVKSRGVYAGVEVVGQVFVERFDENGAMYHWPGVKAGDILSGKVKVPLEAASLQSALKDAETGRAQALKGDSLDIVVLENSQDLDLADGETLKLPPTPDQTDGREHESDPETEKIHYPTQLGSHNVSRNNSPPLNSPYPLYAPGATKGKGGRLVPPPLPSRNPNRPNLNHAHSSQSNYSDALDNQDMVDSPTSIAFNAPSGPPPPHLLPPAQIETSSSQSSKHHTPLGFEDTMSHSDDLPSYAENFPSATSGGTTYPQEKKAPHTSGLIPSDALGMDGQPMSESERKEWEEFLASDSKQNNASSSIERPAAVDQVAERLESSHLSQTEQSVSRDREDILKNPYDEDGKDGFPQSKDREEMLKNPFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1B9IBG9_9TREE</name>
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        <recommendedName>
            <fullName evidence="2">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
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    </gene>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
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    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
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            <dbReference type="Pfam" id="PF00134"/>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF52979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014198.1">
        <property type="nucleotide sequence ID" value="XM_019152060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IBL3"/>
    <dbReference type="STRING" id="1296096.A0A1B9IBL3"/>
    <dbReference type="GeneID" id="30168649"/>
    <dbReference type="KEGG" id="kpin:30168649"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002167">
        <property type="entry name" value="GDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00928">
        <property type="entry name" value="GRAVESDC"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="348"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="74"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="173"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="289"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCF52979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WWC67139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="379" mass="42239" checksum="1D2C9F1B732950A9" modified="2016-11-02" version="1">MSTSPTPSIGPSSISIYTVTPSIKGKERAHSSNYIIASPHEQAWPPARESERWTTSELWKRSRARAKTDRTSWDYVLTSGVAGGIAGCVAKTAIAPLDRVKILFQTSNADFRKYAGTPMGLIHASGVIYKTSGIRGLFQGHSATLMRIFPYAGIKYMLYDWMERILIPTPDHRDPWRFFVAGSTSGVASVLCTYPLELIRVRLAFQTKTSERTSLLEAVKSIYHEKDVVHTSRQKPNISPFIRSIPLYPFYRGFSITILGMIPYAGVSFLTYGTLKKHAADYISYFKDRPTMRDLSCGAVAGAVSQTASYPFEVIRRRMQVGGTLVNGGISAKQAIQTIYNAKGWRGFFVGLSIGYVKVIPMTSISFATWQLLKRSWEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IBS2</accession>
    <name>A0A1B9IBS2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Delta 8-(E)-sphingolipid desaturase</fullName>
            <ecNumber evidence="5">1.14.19.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">I206_00205</name>
        <name evidence="19" type="ORF">I206_101121</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 10737</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.18" evidence="5"/>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF52904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014123.1">
        <property type="nucleotide sequence ID" value="XM_019151985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IBS2"/>
    <dbReference type="STRING" id="1296096.A0A1B9IBS2"/>
    <dbReference type="GeneID" id="30168574"/>
    <dbReference type="KEGG" id="kpin:30168574"/>
    <dbReference type="OrthoDB" id="260091at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03506">
        <property type="entry name" value="Delta6-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353:SF30">
        <property type="entry name" value="DELTA 8-(E)-SPHINGOLIPID DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="FATTY ACID DESATURASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015921">
        <property type="entry name" value="FA_sphinglp_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="8 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="383"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="17">
        <location>
            <begin position="15"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OCF52904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="WWC67214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="546" mass="62310" checksum="BF859F1FA14C1203" modified="2016-11-02" version="1">MTNPVASSSRPKRDLPLLTRPEIAQRICDGQQLIILHSEVLNVSSWSIYHPGGALALLHFVGRDASDEIEAYHCPETLKRMKKFIVGKVKLDSKGWLPLTPPIALGLIKHPNGLKNNWLKEGSVSLGSNILQNNLPITLGSSNEPLPSKLVDELNIGKVEDEIIFNLKSEQLEPAISDLDREIEYNRSKAFQELKKRITDAGLFKPSGWLYGYETEIIRYLILAGGAWGLFFFTNGWIGQMTSALCLGLLFQQLAFVVHDAGHKGITTDYFWDRMIGMTVASWIGGLSVGWWCDNHNIHHLVTNHPEHDPDIQHIPFFAISKDFFGSLWSTYYKRVMAMDAFSKIMISVQHKVYYVVLSLARFNLYANSYIYLLGPRPKRDKFWTYELAGIAWYWFYYLSMLKSLPTWQMRLGYLLVSHIAASPVHVQIVLSHFACSTEDLGPTESFPSRQLRTTMDVICSENIEFIHGGLHLQVTHHLFPRLPRHNLRAASLMVKQYCEEQDIVYKEYGWMDGNKQVLGVLKDVANQLDLLKKVADGEIQERMMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IBZ8</accession>
    <name>A0A1B9IBZ8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Mitochondrial carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I206_00274</name>
        <name evidence="14" type="ORF">I206_101052</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF52973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014192.1">
        <property type="nucleotide sequence ID" value="XM_019152054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IBZ8"/>
    <dbReference type="STRING" id="1296096.A0A1B9IBZ8"/>
    <dbReference type="GeneID" id="30168643"/>
    <dbReference type="KEGG" id="kpin:30168643"/>
    <dbReference type="OrthoDB" id="1747031at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990542">
        <property type="term" value="P:mitochondrial transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045315">
        <property type="entry name" value="Mtm1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45760">
        <property type="entry name" value="FI19922P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45760:SF2">
        <property type="entry name" value="FI19922P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="207"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="321"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="422"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCF52973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WWC67145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="519" mass="55841" checksum="138715C98BEEDE8F" modified="2016-11-02" version="1">MRSHPDLTYPLLPDAQDDLPIPSTSRSIRQGGMSLRDTEISEGEYEWPEAGPSQPKENKIGPFGAKVVAAMTGAMTTSLLMTPFDVLKTRLQTVQPHPRSEFSISKIIQPESLSEECCQTTLLSNSSTNSNSRITPIQCQSTSSTSSALHSSSTNTQHLSFANLRPSGAGVGIGTIPIQEAPEGCLHPSKWSGIWGEALTLENALENRSITRNSIGAGVGVLQLPVQDRIRLNTIQSEQQVMRGFFSELAAVKRENGVRGLWKGVGTAITMGIPSSAIYMLGYEQLLTIISPYFTGSSDPAKNTSSLNRRPDASGNTLTASLTPAPLIAGSLARTLSATVISPIEMFRTRLQALPSVERGSPTYASTTKDMSKLVQNKGVTILWRGLGPTLWRDVPFSGIYWAGFELMKSYLNTSPYTSNFTPISTSFISGFLSGTISALVTQPFDVLKTRRQVFNPTPGCETIRASTIPLALHVIKTEGWGALFAGLSARCGKVAPACGLMIACYEGVGRYLGGREEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9ICH8</accession>
    <name>A0A1B9ICH8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_00391</name>
        <name evidence="7" type="ORF">I206_100935</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Non-catalytic component of the proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014309.1">
        <property type="nucleotide sequence ID" value="XM_019152171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9ICH8"/>
    <dbReference type="STRING" id="1296096.A0A1B9ICH8"/>
    <dbReference type="GeneID" id="30168760"/>
    <dbReference type="KEGG" id="kpin:30168760"/>
    <dbReference type="OrthoDB" id="10248542at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03760">
        <property type="entry name" value="proteasome_beta_type_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000014">
        <property type="entry name" value="Proteasome subunit beta type-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016295">
        <property type="entry name" value="Proteasome_beta4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF6">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001213">
        <property type="entry name" value="Psome_endopept_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCF53090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC67028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="273" mass="30011" checksum="CA9F22E7284C82CD" modified="2016-11-02" version="1">MWKQPAPANSSFNEYNTFPLPQTQRGGQSSHAHGPVGHTQQPLVTGTSVLGLKFDKGVMIAADNLASYGSLARFRDIQRLHPLGKHTLLGVAGDMSDFQWLKKELDALLRQEDALALTDSHPSFSPKNIYELLSNLFYARRSKMNPVWNAVLVGGWDKVKEESFLAYVDLLGTTYTAPTLATGFGAHLAQPLLREAYEAKAGINGEGPLLTQEEAEKVLDDCMKVLFYRDARSINKYQVATITSGGVTISDSRSAETEWKFAEGLRGYGGQTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9ICI5</accession>
    <name>A0A1B9ICI5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RecA family profile 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_00484</name>
        <name evidence="10" type="ORF">I206_100842</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014402.1">
        <property type="nucleotide sequence ID" value="XM_019152264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9ICI5"/>
    <dbReference type="STRING" id="1296096.A0A1B9ICI5"/>
    <dbReference type="GeneID" id="30168853"/>
    <dbReference type="KEGG" id="kpin:30168853"/>
    <dbReference type="OrthoDB" id="1861185at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033065">
        <property type="term" value="C:Rad51C-XRCC3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071140">
        <property type="term" value="P:resolution of mitotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090656">
        <property type="term" value="P:t-circle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19491">
        <property type="entry name" value="XRCC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047348">
        <property type="entry name" value="XRCC3-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46487">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46487:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="8">
        <location>
            <begin position="99"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="553"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="553"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCF53183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC66935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="625" mass="69807" checksum="52AB1EFC1B577765" modified="2016-11-02" version="1">MTEPYLQYTEPFSHYTTLASLSTSSILLTPLPRLADLLKVKLPLAQSYISQVSHAIAPATTRLDEIYDHEQNIGPSRIPLDEPIVDDFVISRKGKERAREKWISTGDVGLDKALGGGIRRGCLYEISGESASGKSHLSLHLALAVQLPSLSSSPGGSLVLTSERDLSTDRLVQLGQHLLVTHESSEDTTERSARNLLDNILTNRIADVEALEHALNYAVPAILDSRLGDVNEKNGQLPIRLIILDSITALFRGSSNANQPPSAHNAISLAERSKHLCVIADILKSLAVKYDLTVLVINQVSDVFQRLPPIINPLPSFSQQPTSSFSQTAIFTGLTNSQQPNEEAAMLYKTQSRWFSGENDQLKKEAALGIVWANAVNVRIMLSRTGRRRLMDQVELTSHKRKRLNSQGEEADKPGYAPRMEEINDIKQTLIRRFHVVFSPFSAPSTIDFVVTSSGVHSLTETYKKIDTTETVIKRKIKEEKERELEKEDEEFIPRDEIGIDHQYGMNRTMEDEQTKVTEEWDEVFDDFGELPDEFWQGKYDLGVIDFEAPERKSDQLLQNDRRGADQHQSIEHKAFISDDDDDLFSSLGDIMDGNEDQSGARLDSAKSASISELETNQEDVANGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9ICK0</accession>
    <name>A0A1B9ICK0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_00488</name>
        <name evidence="4" type="ORF">I206_100838</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
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                <person name="Mohammad A.W."/>
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                <person name="Yurkov A.M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014741.1">
        <property type="nucleotide sequence ID" value="XM_019152603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9ID31"/>
    <dbReference type="STRING" id="1296096.A0A1B9ID31"/>
    <dbReference type="GeneID" id="30169196"/>
    <dbReference type="KEGG" id="kpin:30169196"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19510">
        <property type="entry name" value="RecA-like_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000768">
        <property type="entry name" value="Probable mitochondrial chaperone bcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="BCS1 N-terminal" evidence="16">
        <location>
            <begin position="69"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="280"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OCF53522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="WWC66598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="504" mass="55940" checksum="74AD8B2B6B664C19" modified="2016-11-02" version="1">MFRPRPAQQTAVSQNSEAGPSINVITSPDIGQGNDVSTTSIPGPSAEDQSFVSRIMSDNPYFSAGAGLMGIGVVLTVLRRSVTLGTTFAQRRMLVTLEIPSKDRSYPWFLEWMAAQSASQVGKGKKPMGFRSHELAVETSYKQHENGSSEAVFNLVPGPGTHYFKYQGTWFQVKRERDAKLMDLHSGSPWETLTLTTLSAYRHLFSSLLTEARALAEASTEGKTVVYTAWGVEWRPFGKPRGRREMGSVVLAEGVSEKIETDLRSFLGRGKWYAERGIPYRRGYLLHGPPGSGKTSFIQALAGSLHYNICLLNLAERGLTDDKLNHLLGLVPERSFILLEDVDSAFSKRVQTSEDGYKSSVTFSGLLNALDGVASSEERIIFMTTNHYERLDPALIRPGRVDLHELLDDAKGEQAKRLFIKFYGNSTTTIENGQEVEKGRILREGEIPLTDQEVEDLGNQVQKIIEDEYSRGRTISMASLQGLFIRTGAQECLEGIRELCRPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9ID54</accession>
    <name>A0A1B9ID54_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ornithine carbamoyltransferase</fullName>
            <ecNumber evidence="2">2.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_00884</name>
        <name evidence="9" type="ORF">I206_100445</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="2"/>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014798.1">
        <property type="nucleotide sequence ID" value="XM_019152660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9ID54"/>
    <dbReference type="STRING" id="1296096.A0A1B9ID54"/>
    <dbReference type="GeneID" id="30169253"/>
    <dbReference type="KEGG" id="kpin:30169253"/>
    <dbReference type="OrthoDB" id="10252326at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019240">
        <property type="term" value="P:citrulline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45753">
        <property type="entry name" value="ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45753:SF3">
        <property type="entry name" value="ORNITHINE TRANSCARBAMYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/ornithine carbamoyltransferase carbamoyl-P binding" evidence="7">
        <location>
            <begin position="36"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Aspartate/ornithine carbamoyltransferase Asp/Orn-binding" evidence="6">
        <location>
            <begin position="214"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF53579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC66542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="367" mass="40510" checksum="E4D6E394A29C24BD" modified="2016-11-02" version="1">MSSLARPAAGTARNALKRSGQRYPDNVKIRQSSPPHLLTLADLSPAQINTLIQNALTFKYVFKNLSPRALIPSLDNRTIALLFSKRSTRTRVASETSAQALGGHPMFLGRDDIQLGVNETLEDTARVVGSMVDGIMARVGGHHEVETLAKYSPVPIINALSDLYHPTQILADIMALHEHYAPTPTPPPPAEGEGSHTSVLKYFQSTVDPIKTLKGKKVAWVGDSNNISNELLVTLPRLGMEFSLAAPKGYDKVDERVWNKVTEAGTESLVTLTNSPSEALANADVVVTDTWISMGQEQEKADRIKAFEGYQITNKMVTDAGAKEDWRFLHCLPRKQEEVDDEVFYGPRSLVFPEAENRKWTIMACFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IE43</accession>
    <name>A0A1B9IE43_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Adenylosuccinate synthetase</fullName>
            <shortName evidence="11">AMPSase</shortName>
            <shortName evidence="11">AdSS</shortName>
            <ecNumber evidence="11 13">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I206_01000</name>
        <name evidence="15" type="ORF">I206_100325</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Plays an important role in the de novo pathway of purine nucleotide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11 13">
            <text>IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11 13">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 11">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 13">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="11 13"/>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014913.1">
        <property type="nucleotide sequence ID" value="XM_019152775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IE43"/>
    <dbReference type="STRING" id="1296096.A0A1B9IE43"/>
    <dbReference type="GeneID" id="30169369"/>
    <dbReference type="KEGG" id="kpin:30169369"/>
    <dbReference type="OrthoDB" id="10265645at2759"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046040">
        <property type="term" value="P:IMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.170.10:FF:000001">
        <property type="entry name" value="Adenylosuccinate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.300.10:FF:000002">
        <property type="entry name" value="Adenylosuccinate synthetase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033128">
        <property type="entry name" value="Adenylosuccin_syn_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042110">
        <property type="entry name" value="Adenylosuccinate_synth_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002223">
        <property type="entry name" value="PRK01117.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00184">
        <property type="entry name" value="purA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="ADENYLOSUCCINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846:SF0">
        <property type="entry name" value="ADENYLOSUCCINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00513">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 11 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 11 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11 13" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="17"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="18"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="43"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="45"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="304"/>
            <end position="310"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="336"/>
            <end position="338"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="418"/>
            <end position="420"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCF53694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WWC66423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="430" mass="46867" checksum="88E3CF3611666308" modified="2016-11-02" version="1">MAPAPEGVSVVLGAQWGDEGKGKLVDILAAEADICARCAGGNNAGHTIVVRNAKGEKTSYAFNLLPSGLINPTCTAFIGSGVVVHLPSLFNELDTIERKGLKVADRLKISDRAHLVMGFHQIVDGLKEIELGGSSIGTTKRGIGPAYSSKASRSGLRVHHLYDPSFAAKFRKLVEGRFKRYGHFEFDTEGEIEMYLAFAERLRPFIVDGPLFMHNALQSGKRILVEGANALMLDLDYGTYPYVTSSSTSIGGVVTGLGIPPMAIKKVVGVIKAYTTRVGGGPFPSEQFGTIGETLQEVGAEWGTNTGRRRRCGWLDLVVMKYSTMINGYTSLNLTKLDVLDGFEEIKVATGYKIDGEQIDGFPADLDRLAKVEVEYTTFPGWKTDISNCKTYEELPENAKKYIKFIDEYLGVKTQYVGVGPGRDQNLIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8KZM0</accession>
    <name>A0AAJ8KZM0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_100715</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058360.1">
        <property type="nucleotide sequence ID" value="XM_070202259.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30168981"/>
    <dbReference type="KEGG" id="kpin:30168981"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052007">
        <property type="entry name" value="Bud4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36100">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36100:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="1538"/>
            <end position="1654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="691"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="797"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="851"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1373"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1473"/>
            <end position="1494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1598"/>
            <end position="1619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1670"/>
            <end position="1710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="172"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="237"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="329"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="702"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="731"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="744"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="860"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="895"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="919"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="997"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1049"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1128"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1145"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1181"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1479"/>
            <end position="1490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC66808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1710" mass="184496" checksum="97F876BAFA12BDAF" modified="2024-07-24" version="1">MSGSTASPSSRLRLAPHSSPISASDVARHSIINSSAKGWSPLQINKRDSINQSPLKPSLSPDPNAPRRSSSSFKHVSKNSLVSNSPFKSPTTVQGAQAAGFTLDTGGEKVIHEKRSTRALGETPSPAKGVNVTSKAAIGLGIGISPSKRSTSRSSSGSGSGSGNAVIGQRRVSTEKGKVAFPVVERKTSSERKVSGSKENESPDVRSSKRVPRSSMGFKDLAKGTLVTKSPFKRVPSGGLSSTSSSKANESTSILDIGPSPKTIPVERDDVFSSPSPRRLSASKQQQQRRASPSASLGVGARSSNSPTPSPPRSVPQPLLTTSNTSAGPSPLSKSLSIPSIDATPTPTPHKSAMTPSRRLRGPRDLSVGLESPTRKTVTFQSVPDVKEFETISAEPSMDGSFEVRQHDDEDEDGWADEGINMSLPRDSSLEELLSDTHAIDRHMQAVAASASPILTEENDGTMPEDSTTANFMDTLIEEGLFSPPTMDTPAFEDQSAFELPLEPVDNDSEPPFLATPSLGGSVHATPLFAGGMFGETDSEGIPYGRTHHAERAAIAHSLSPAKIALVEQPPLPRDVDHSMLLNANAAQPSLAIPQSPVHYPEYNDPFASASAPHAHQVGAMPDPFITIQTATQVLPIRHEEREEDGIPLGRTSHVERLQARRMLATQSLGLGMPRSPAISQGLTRNYAQEEPEEAFGEHSQGEVSHNPAPQITRNASQESEEGTKRRLPKIPAPAPMPVDIPSPVTSPNKNEQLLDTNDKLSVTEKRTSKFDIGGFSLPFIGATSPFFNTAPATFEKQPSIDGLSTSSNEPERPLTPPPAIREALTERKESPHKLPDLNFHFEEIHLQRTDSDELKRTATIKSNPVSPIKASNSDDLKKAASAPGAREISKSAVPASSGSNNLPASASTGSLKNDFGGTSTTTTKAQDSTTTKVRQRISREMIRETINQRIAEGSLSRRPASAGDLAKSLPVSFADGLQQRRTSSVDKELPPPPAESPALASSSSSPPSSAQDLAPKMQKAHTTDNALGRVSESRPTMRPRSQTQSAHEVLKQNEKDGILDEPKSALDKLTSSLPSPAEGAVLKREMSGSIAAEMPPQPQTSARPISILRNPYPNPNKQDALLPPADVQSNQRSKSTAPASGEGMKAREEAINARRREKERDVSGVSTGSRRSRRSLSMGDVDKEAEQAKQFRRTAKGNPRLTLGIDSDQQSILDAFREEITQIDRGYKVREKAVVRASYHDKVRHNKAGDIDSGKAWKQLRRPSDMNEHAAEIRAMRARESTSGKASGTIFVKVLGIEGLQIPVPDQTTYFCITLDNGIDYIRTPYSVLGEGAKVNQEFSLVEHPNFEFSLSLDIRRDPHIIKMIHQKPEVPTSLARPVTPSSQAQKGGFRSLFASPRKPKASKDPRSTTPLPTPPNTSVVKPDNIIKYLSSSSGSTIAKTHIAFKPIAKNCESRVLEIRYPMFAMFKGEPDRARDVPSTPMTSSTASSNGTTRKQLAKITLQIFRLPPIPGLKGDELPQCIDEALRGMRHHAWHEHEYHEGVLTQEGGDCTMPKRRLFKLIGGNLVAINEVTKKEVTKIDLRQAIAVIDLNASADGTPKSKLTMRPRSSDEGLSTRPRSFMVEFKDGEGISFAADNDKSKEVWMDTLNGLIGKIPTNPLWAELLSTRQKEKIAKRTPSSSSLAKEAKRQASSSGRPVSMPLSGPSKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8KZR3</accession>
    <name>A0AAJ8KZR3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_100666</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058351.1">
        <property type="nucleotide sequence ID" value="XM_070202250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8KZR3"/>
    <dbReference type="GeneID" id="30169028"/>
    <dbReference type="KEGG" id="kpin:30169028"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000061">
        <property type="entry name" value="MFS sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF68">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="432"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="469"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="499"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="77"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="567"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="567"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC66761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="609" mass="66413" checksum="8848FF65200F5C1E" modified="2024-07-24" version="1">MASSGGAAFSIARPGGQWQNNDLSSGGTDEMRNGRASGRRFGSEDTGGETLVADVDTHYAAQLKPSRLSGKSLTYMVTFVAGTGFTLFGYDQGVLSSLLTLPAFEEQFPQTANGFGGSRSATLQSFLVAIYELGCMAGALSNLYVGDRLGRRHTITLGGCIMIVGAILQTAAVDYAMMLVARVVTGVGNGLLTSTVPAYQSECAKPHKRGQLVLIEGSLITLGVMMSYWIDLGFFFTTGSISWRFPIAFQILLAAIMIVSMYAFKLPESPRWLAAKGKYAECLAVLAALEGTSVDDKKVMSTFNGICDAISAEQAGGFGFRELFTNGRGQNFRRMLLGVTAQCFQQICGINLITYYLTSVLTDLGLGAEMSRIISGVNGTCYFLTSIVALFVIERVGRRPLMFWMALLQSFTMAILAGLYNKSKEDNKPAQVISVLCLFLFNTWFSIGWLGITWLYPAEVTPLRIRAPANALSTASNWIFNFMVVMATGPMFANIGWGTYALFAAINGIIICPVVWIFFPETKKYSLEEIDIIFALGHNEKKSPVWYSKRPEDIPEAGSKEAERILGREVPSHPDMSEKKTGHKGMRKVIKDNDGKPVTQHFENANSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8KZW4</accession>
    <name>A0AAJ8KZW4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VHS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_101420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058486.1">
        <property type="nucleotide sequence ID" value="XM_070202385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8KZW4"/>
    <dbReference type="GeneID" id="30174979"/>
    <dbReference type="KEGG" id="kpin:30174979"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21383">
        <property type="entry name" value="GAT_GGA_Tom1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045007">
        <property type="entry name" value="LSB5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789:SF2">
        <property type="entry name" value="VHS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VHS" evidence="2">
        <location>
            <begin position="495"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="668"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="808"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="976"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="808"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="849"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="904"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="925"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="986"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1026"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1044"/>
            <end position="1054"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC67512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1140" mass="124176" checksum="4E2B447F0FD1C689" modified="2024-07-24" version="1">MKRLFRTSKSPVVDPLPPPISTPASGTSTPTNHHQEHRWPFGHSHQPEVTPFPIDAGRENASTLPPLSNEARKGKQRGPSGGNNPNAPSLLEIRQMQDRDQAMRSVQTHHHQHQNQHLHQHQPHQSKGYGGSNASASDEWTVISPSNSHIPIPSPGSNGHGRNQMYDSSLFEPLAIPNAAFATSPTPSNNDPSSVSTHTVLYLPPGARPATPPSMRPPPLGSARNSQASLNSMSTAHYGEAGDIISPPSNNVGRERGHSVVSATGSLSNRSDHENPTYTQQQNTNSYPYASNNTNMNQTIPTNAPTQSSKLQKAYPQPTRSPLANTYPSPELTSFPSPHPYSLPPPPPPTTQNLNGFNPMVPRAEEMPNVVNLSRRGSQMEGKEKKRGFLGMGWGKGKDKEKKDTGDVNRPITEEPRRSFDGWRGQTVSGETESQPSSTHGHSTSHEQEDAPRGRLLGLDFGGGGKQQQQHQQQQPNDAGSAIRWLCAQPDPPPSQIYDVCDRIHKSQGMEGITKDAARAIRKEFKGGNENERKNAAKVWLYLMRNVSVKGFRQHASSKKFLSSLEPILLAPASKPLVSQPTYKLITDILSDLTFSYGLEKGCEGLAELWKKVKLPQESEIGNPLPADHPIFSPEPFYPQRQAYHYASPDQSFPSSRRASSPSLQYLSANHQDIPNGDQRGPSPNYGGPRYANLPNHGEDIRRLVDECTAAKESARVLSEALIFTGPDELEQKPVIGEFYRKVFLAHESLTNQMDWAQAEAARSRESHAALTLNGNSDTDNTKHDTPEEQALATLLEAHSALGEALKQHDDLTRLAGEENEMREVRERSKKETKLDRNQHMYDNSGLLPPSSNQAQASSSRSPSPVPHARLPPDNTLKVTSSPRNYDLPLPPLSNGTAALPIPGSNNPFRNAIKSRTPSPDQRHPLPQLPKLSSSPSRTSSPLGRSRMGGPRPLPNPFAKGNNASHQSLANLANSAHVGSEGGNIPSRNGSGDTPSRSGTGDSSSQGAHVPAEEVDGDDLPPKPIKPSRKALGKRRAVIDEDNNFNPDDMFNPNHTDPRSINRDGGQGNPNSNNNENENDSSEEDYITLLDDKTKIKPKIVYAYDAYEERQLELKKAAQALKISEKYGGGGGGGSGGGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L1V7</accession>
    <name>A0AAJ8L1V7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_101897</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrion-specific ribosomal protein mL54 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008453.2">
        <property type="nucleotide sequence ID" value="XM_019158707.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L1V7"/>
    <dbReference type="GeneID" id="30175381"/>
    <dbReference type="KEGG" id="kpin:30175381"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_mL54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L54, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML54"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="27"/>
            <end position="41"/>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC67978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="141" mass="15575" checksum="6AA8A984A170218D" modified="2024-07-24" version="1">MSFISIIPRIVSRQPSQIYRISINQFSSSSSSSAASSSSSSTQPKPKKSSKVISAAPAGTKLTGLSILKDKPDPIALEDDQYPTWLWNLLEDTSKAHKIAENQIELHGEGEKGFDPIKEKRKLKNLNREKIKASNYLKSTT</sequence>
</entry>
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    <name>A0AAJ8L1Z1_9TREE</name>
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        <recommendedName>
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        </recommendedName>
    </protein>
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    <organism evidence="5 6">
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
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            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Roberts A."/>
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                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
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    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the universal ribosomal protein uS7 family.</text>
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        <property type="protein sequence ID" value="WWC68699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
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        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:translation"/>
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    <dbReference type="Gene3D" id="1.10.455.10">
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        <property type="entry name" value="Ribosomal protein S7"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="4">
        <location>
            <begin position="71"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC68699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="211" mass="23620" checksum="909D758305DAADD3" modified="2024-07-24" version="1">MSIRTSSSSIRRTFVTSSRAFIESPPAISTQTGFSPLRDLLNSTSSSSSKLTSEPISDSSISQFNVHNIPPKADPTLDLFTNCLMKDGKRDEAQKMVSRILTMLHQSTNLSPQPLLKQAIELSSPSIKILSMRKSAKTILTPRALTERQRTRQGISWLLKASEKGRKGLISRDQRISKEILSILEGNSDVFKWLDDRHKTAYLNRSNMTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L298</accession>
    <name>A0AAJ8L298_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Exocyst complex component Sec10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_101715</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058546.1">
        <property type="nucleotide sequence ID" value="XM_070202445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L298"/>
    <dbReference type="GeneID" id="30174687"/>
    <dbReference type="KEGG" id="kpin:30174687"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009976">
        <property type="entry name" value="Sec10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048627">
        <property type="entry name" value="Sec10_HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048625">
        <property type="entry name" value="Sec10_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100">
        <property type="entry name" value="SEC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07393">
        <property type="entry name" value="Sec10_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20667">
        <property type="entry name" value="Sec10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec10 N-terminal" evidence="7">
        <location>
            <begin position="114"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component Sec10-like alpha-helical bundle" evidence="6">
        <location>
            <begin position="248"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="271"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="992"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1002"/>
            <end position="1016"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC67802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1089" mass="118919" checksum="03D5A77905EE3667" modified="2024-07-24" version="1">MSASPAPSGGTMSVPGTPPRRPAKRDPSSLALSSIANNASASTSTSISANRNSGENGSIPSGTVRADIKPRDPIIERALQLSTFESNYSTEDFIGTLSEKLISESKVDPGPFNPKPFLQTFSPALDSLLSLRQQVAERTKKMETDVRRAEREYGRRLRELDGGFEAIGNSFENLESKITDVGRTAVRMGEQLDTLHQTRSTAQSTSLLLSYYLSLAHQTSISSPDGTSSTPLEVLFATRTSREGRSRLAVILRRLMAVSKDVADNATALLNETEQAQTPKEPNGNTGTSTTASDAPVSAKAIGKRKMEKEKAERVRDEIERYCEKFEKEVLRLFDRSYRKGDPRMMAHCAKTLQDFNGGASCVQIYVNQHDFFISKDRLLEEAVRLDSAVDGEKPVDLWTTIGDPDAPPPITEPGMEALLKEIRVTVSQEAQIVKAVFPNPSAVFQVFLQRVFAQVIQQHLESLLTRASTTSTLAVLRILHLTHSICSSLVEDLKTYDLTLGAETAGLSKAPTTASGPLATMLDHALEEMFIPWLEGSRYLESESKNLVELYAGLLSRFTRYHETVLKAKPNSILDKVVNQLQTSSSAATSSSTAQTAAAAISKYANLFTSKTGGTSTPIPGQQVKPYGTNAAHLGVQGGGGTKSAMLTNGTQTPVAAEPRPGLPRQDTVLKGELINKGLEDKVWLTDGVLTIEMAERMLKWHAEAVGRAVELSASGDIGKNALSLSKVLSEAIGRSFVETALDSALARLDNQETRSAEPDLQPLTVIKPSDQICHLWQRYTSTALLPLSGTVMSIRREMNTINSHNVVRMEGKINSVIQKALDGIVSYLSYLLTKQKKNDYKPKNDELSFARTNTEPCELCTDFLVTIRDTVNEALSGKNAEAFLTEVGVAFHSLLLDHYKKFPVNPTGGLMLTKDLASYQETMSSYGIQAVNDRFDMLRQLGNSFIVQPNVLKSYMTESHLGRIELRLLKPYLTQRSDYSQFSKLLQLDDSTAGNEDHPSSSSPLSISSTISSTMLNRSHSRASGLGKAGSRLSTMSMSGVAGAGMGKLKEMLKEFDTMTPEESANARKLHNSQRGGYQPMFYMGLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L2Q4</accession>
    <name>A0AAJ8L2Q4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_101782</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Conjugated with ATG12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Preautophagosomal structure membrane</location>
            <topology evidence="1 6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ATG5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058555.1">
        <property type="nucleotide sequence ID" value="XM_070202454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L2Q4"/>
    <dbReference type="GeneID" id="30174615"/>
    <dbReference type="KEGG" id="kpin:30174615"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044233">
        <property type="term" value="C:mitochondria-associated endoplasmic reticulum membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000347">
        <property type="entry name" value="Autophagy protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.190">
        <property type="entry name" value="Autophagy protein Apg5, helix rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007239">
        <property type="entry name" value="Atg5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048940">
        <property type="entry name" value="ATG5_HBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042526">
        <property type="entry name" value="Atg5_HR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048939">
        <property type="entry name" value="ATG5_UblA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042527">
        <property type="entry name" value="Atg5_UblA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048318">
        <property type="entry name" value="ATG5_UblB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13040">
        <property type="entry name" value="AUTOPHAGY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13040:SF2">
        <property type="entry name" value="AUTOPHAGY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20637">
        <property type="entry name" value="ATG5_HBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20638">
        <property type="entry name" value="ATG5_UblA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04106">
        <property type="entry name" value="ATG5_UblB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3 6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="4 6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Autophagy protein ATG5 UblA" evidence="10">
        <location>
            <begin position="19"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy protein ATG5 alpha-helical bundle region" evidence="9">
        <location>
            <begin position="164"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy protein ATG5 UblB" evidence="8">
        <location>
            <begin position="259"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC67865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="349" mass="39168" checksum="428D00D6610F4A4E" modified="2024-07-24" version="1">MSNTNPVHSSTNLFRRLSWQTSISISIRIADGEPGAGTGADKYFIQAPRYSYLPLLIPEIRENLIEVALDDRQSEETDEKDWWFEEEPDEETGAFASQGACRWHWPIDLLSIYSYISRPRRLPSSSASASSSTSTTIREPKQLRLILHLSKPPIDKLLMPNNIENCKSLWLNQVKEADFVRWRNTNKVTSLRKTDLDNGWDGIVQDDYDLYLRMASRVLPLPIAPATNNVTSPQPSRPPSTDPSSSSIKPESAYSTRGIPLKLYLPDNAPVIQEIIPPLGTDGKPTTLLSVLRQHLHLLFPSRPQDPYSMAFPIAQGILIPEYSDVAWLSACMCGADGWLRIGICLRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L3V6</accession>
    <name>A0AAJ8L3V6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Chromatin assembly factor 1 subunit A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_102573</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058690.1">
        <property type="nucleotide sequence ID" value="XM_070202589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L3V6"/>
    <dbReference type="GeneID" id="30171293"/>
    <dbReference type="KEGG" id="kpin:30171293"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048800">
        <property type="entry name" value="Cac1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022043">
        <property type="entry name" value="CAF1A_DD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15272:SF0">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15272">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A CAF-1 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21796">
        <property type="entry name" value="Cac1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12253">
        <property type="entry name" value="CAF1A_dimeriz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromatin assembly factor 1 subunit A dimerization" evidence="6">
        <location>
            <begin position="494"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Chromatin assembly factor 1 subunit Cac1-like C-terminal" evidence="7">
        <location>
            <begin position="754"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="243"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="348"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="534"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="697"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="821"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="278"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="305"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="440"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="535"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="707"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="825"/>
            <end position="863"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC68642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="887" mass="97674" checksum="4A9E635D3EFDE1B2" modified="2024-07-24" version="1">MTTETPRLVEPMAPNTTLENTQYSMESSPIRELKRKAGEGGIDVENKENGCIDKKLKAGSAGSLVELKGRKLIFKQESSGRKLPRRQLLNFEGWLLDEIEAGNKITDIPEEYHGLIVMAGHELTSSNESLFIKHLKSALEITKGGQDPLPNETLTSLIPKLFALKQYGIVPADFSPSTSTAKVPAALQIRCWEATDVAKHFSASQLEEVLARRREREQAREECERILNGLDDIEKLELIKGDKADKSQAKDVKEPERVAKADEVEQSPLISRRKSREGTANTVESRGRSASPTKKGKLTPEEEEAARLKREEREAKKAEVAEKKAAREKEQERRAAIVAKQAKTMMGFFKAKPPTTPPISRASEAGPSNPKGSASPVKGGGSDYSRAFRPMNQRPHVHVAEINRWRSNRASMASNSLEEEKGSNVEMWAPQDFLNDHLRKHRTRSRTSRSRLPRGLKTMPLGGSVAELYGTLEDAEDPRAVLSQLKDRRRFPWKTLSFDQQARPPYCGTFTKKSVVVGPRTPFAQDPIFDYSYDSSDDWVDDEGGEDVDDFGEGEPKEDEEDEEGSESEGEFDDWLDDAEDIEFTPADGDISSLAEPEQARLPMKVVKKSRDIAKKVVKLIPSWKGPIWEKSVGEEGSEGLEGYRIQLLNDTPQSVDPFTYNSTEPIQTFKTLFTTTAIGISLNVRCLLAAEPITVTPTPAPPAPEKPVSIPNSSSISSKPVYNTSPSTNGEIIAQNPARSRPPPKIAFPEEHLPELYQMIEGSKKIKPDLVSQLRERFENIATKAAIEAKLKEVAVREGKTKDSQWKVKAEAWIAVGLTPPAPASTASTAPTAAPATIASPTSAPVSKSVASFFSSPAPTSPRLATSGTNRKPLEGTVDEPMVIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L4P1</accession>
    <name>A0AAJ8L4P1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_104490</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKN1/KRE6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059061.1">
        <property type="nucleotide sequence ID" value="XM_070202960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L4P1"/>
    <dbReference type="GeneID" id="30170390"/>
    <dbReference type="KEGG" id="kpin:30170390"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02180">
        <property type="entry name" value="GH16_fungal_KRE6_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000140">
        <property type="entry name" value="Beta-glucan synthesis-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000135">
        <property type="entry name" value="Related to KRE6-glucan synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF15">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="11">
        <location>
            <begin position="190"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC70539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="604" mass="65944" checksum="83C582F33025B7DE" modified="2024-07-24" version="1">MSYRPVPLNDNPPPLPPKNAEASSSRLHARTASDSRRYGPRVSSQPVPPTTSLLPTRSARDDPRAPIAEGDQRPWGTGEHVGYAAFDGNAEEDDWLHNPDPRRDGKISHDRGSLFTVRGATNIGCLALLAIGIIALFAGYPIIDFYTGNELRSHGAYNLGGINSTGQVPQIAGFPTLIDSDTPDTAYSRVGFDGEDYQLVWSDEFNKDGRTFFPGDDPYWTAADLHYWATGDFEWYDSSAATTKDGNLVLTMTQEPIHDLNWKSGMLQSWNQLCFQYSFYIEVRASLPGNTRTGGFWPGVWTMGNLGRAGHGGTTDGLWPYTYDSCDIGTLPNQTNAEGTGPPGALTSGDDDGPVSFLPGQRLSACTCKGEDHPGPSESYGRGAPEVDILEGQINLAEQMGELSQSFQVAPFDLGYQWLNSTKGAEIYDKTVTKFNSYRGGVYQEAVSGLTLVEPNGYEGGGGGFAIHGVEMFADPNHRGNGHITWVADGKKSWTAYPAAVGPISSMQIGQRLIPEEPMSLIVNFGMSNGFQPVNFNQLEWPAKMLVDYIRVYQRPEGRIGCDPPDRPTAEYISRHMDVYTNPNMTTWDAAGLSFPKNSLVDTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L5R1</accession>
    <name>A0AAJ8L5R1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_103862</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC69918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058943.1">
        <property type="nucleotide sequence ID" value="XM_070202842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L5R1"/>
    <dbReference type="GeneID" id="30176184"/>
    <dbReference type="KEGG" id="kpin:30176184"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042578460" evidence="2">
        <location>
            <begin position="21"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC69918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="73" mass="8183" checksum="44A1A1BA98218206" modified="2024-07-24" version="1">MSKIFVFLMVFTLCLSLIQAKPIITPTRTNSKVTRNDRLTNSQRIARGLPPRAPVRLYDPTAPHPAKRAPSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L7K3</accession>
    <name>A0AAJ8L7K3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6699 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_105008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC71055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059151.1">
        <property type="nucleotide sequence ID" value="XM_070203050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L7K3"/>
    <dbReference type="GeneID" id="30170916"/>
    <dbReference type="KEGG" id="kpin:30170916"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046522">
        <property type="entry name" value="DUF6699"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20415">
        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6699" evidence="1">
        <location>
            <begin position="65"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC71055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="215" mass="24521" checksum="2189DB8F39BF5DF3" modified="2024-07-24" version="1">MSGIGIDPPGAPRDAAITIGPFKPSRPGYGPVLSYLQAAQLDTPLKIHPLLQLRTWDAKPYAKYLAWNVIEHPMFAAIWIDYDGIKERGQPATSPIVEELNIGHVETGWSIRVRNRMGITCEDVLFAIYDFFASPLYVDELGEMHPRAVRIMEQQYFEKRRMGFFDLMEGYRKSDALLGATYFDGIHNDQESVERLKKKYNFHSANLLLLRLGNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L7W5</accession>
    <name>A0AAJ8L7W5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_104701</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059088.1">
        <property type="nucleotide sequence ID" value="XM_070202987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L7W5"/>
    <dbReference type="GeneID" id="30170608"/>
    <dbReference type="KEGG" id="kpin:30170608"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848:SF4">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="7">
        <location>
            <begin position="118"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="8">
        <location>
            <begin position="229"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="365"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="440"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="536"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="378"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="440"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="468"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="536"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="560"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC70750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="682" mass="73991" checksum="FB284078B431682B" modified="2024-07-24" version="1">MTDQNTRPRPRLPGRSKSNIKDDPPFDAAKPDEKAVDDVYKQVNSTGSLELAAKALEKYTNNQKVLMNENDQDSEELGYLNKHNLQEDVIMSSDDDDDFITSPLKQNNKSDGGSGVIHIQEVVDGLWIGDLVSAMDIEGLQKRGITNILSLLRPALEFSSEFAVYPLEIDDSSDTDILTHLPSCVAWISSILELRGKAENQTNPGFGNLEIDKDPIISNLAASPKVGGVLVHCQAGMSRSATVVAAYLMREYDLDPVQAIVALRDKRPVVDPSETFWHQLGLFYNADGRVSLKDKSTRRFYMDRTASQFMNGDGGAPSIETMAKYPMTPTASNPPTPGGAHGRRKIRCKMCRRHLAVREHMMDHILDQQPVSRPRTPSIVTLPSPKLSNPPSFPTVTGERERRASVVSDVINPLTGLPGRRASHASISSMTGITTQYENSVNSKDQQQSSPGAGIPLPKRSTTTPGLSLTASSPDPNSSSGSPIPNILGRMDNNASPKPISPTIEIGSPAGGRVFQSAEQLASSLPPHLLALRMAGSGSSGLPSPIGSSPNSSPEKDIVSTSQTFPPSQQSQNVSNAARRMSMLTMTPNTPEGERRNSISENLNNGGYPILVNNKCSGYFVEPLTWMEPVLQKGEIAGKLICPNEKCGVKIGNFDWAGVQCGCKQWVTPGFCIHRSKVDEVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L830</accession>
    <name>A0AAJ8L830_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_104516</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059066.1">
        <property type="nucleotide sequence ID" value="XM_070202965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L830"/>
    <dbReference type="GeneID" id="30170416"/>
    <dbReference type="KEGG" id="kpin:30170416"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="30"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="91"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC70565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="771" mass="86142" checksum="5627BC37E754B9C2" modified="2024-07-24" version="1">MPTGESSNPPVYNADTASRPKKKRTNVGKACEPCRRRRCKCDGVKPSCTTCAVYKDECYWEPREDYRKPLSRQQVQALTTRVQDLERLLREHGLDPGSAGPSDVKDGSDEEAGERKKDIVDEPSGDIREWSQDHIVEGETGELQVHGPTSAFRHLGKYSHDDVRLNHEMSPESPDPLPYGYARHLPQDVYITEEQHDQAINRFFQFYASWGQRSNPILFRQDLHTALYTNSDVKTPHYSPMLHNAILAIALGFSDEAFLRTSEIRRVFAKKAKDFIDYEGMNPTVATVQAFAHLASYHMGLNMDDTRLLKKGNVTSAQARDRNVTFWTTFVQEGLWAPYIGRSISLPEFTASPPTVDEELDQLLWTPEQPPTGIDCSLKAQPGMISTTFVHTVKLMQIGERIMNTLYGIKADMSTLIRTGVISEISLSLSTWLESLPPSLTFHNHAPKNGLPHILMMHLSHAWLVILLHRPFYRPLAPLPNGANSDSAAASGTSTAAWAVKQCDKAALHMIGLLQTWHRFHNLRYCPPTAIQCCFIAGTTHLLSLASSQGPKKQSEALLRAQECIKLMKLMAVSWPAAKHQQMLLENLLSEYGLSMGSNRLTQQIDQMNLEPQRHPHTQNQMPMTAQNIAYEQIPSTAFKPSIPGPVVDPNMVLPAPVSVNSSNASPPPTANGMLEGSNAWMNMNAVGSGLGNNSYLYNPITSSFDASALPSIINTLMPNPNRTFDQPPHTVWDPNGFELDRDTQALLDNILRPHLDVEDPLQFDFNQGYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L859</accession>
    <name>A0AAJ8L859_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Charged multivesicular body protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_104837</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059107.1">
        <property type="nucleotide sequence ID" value="XM_070203006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L859"/>
    <dbReference type="GeneID" id="30170746"/>
    <dbReference type="KEGG" id="kpin:30170746"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF5">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="154"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC70885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="25084" checksum="E725462848922A66" modified="2024-07-24" version="1">MGYFQAAMVRMGMAQPGPKITAQDRAILDLKLQRDKMKQYQKRLQVVLNREQEIAKEALKAGNKTRALTALRQRKYQEQLLAKTDAQLMTLQELVSTIEFTQIQNTVMHGLEMGADVLKQLHAEMSLEKVERLMDQTREGVEYQREIDEALMSQMSPEEEEAVQAELEQLQREALPTIPAVPDQQPVSLPDVPVEEPTTAQPATEERRAERKEERVAMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L983</accession>
    <name>A0AAJ8L983_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_105373</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059210.1">
        <property type="nucleotide sequence ID" value="XM_070203109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L983"/>
    <dbReference type="GeneID" id="96955756"/>
    <dbReference type="KEGG" id="kpin:96955756"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WWC71417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="160" mass="18757" checksum="80AA5036EFCD7563" modified="2024-07-24" version="1">MSDSGFELIRLDRALTGFEQSIPEITKSSIRENWDMDKIKEETKSKVDNYVTTQQQNQAKSSRLSHFSDMITGPLKSKSRSELKQQIIKKQERLNFLIENVDILPKKIKDTERELLAATVEDFFIEGLWMKPRIKRNHVMRISKIIARIWMLTLEKAFGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L9T9</accession>
    <name>A0AAJ8L9T9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-hydroxybutyryl-CoA dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_106187</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
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        <property type="protein sequence ID" value="WWC72225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="kpin:30173381"/>
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        <property type="component" value="Chromosome 8"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075:SF5">
        <property type="entry name" value="3-HYDROXYBUTYRYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="6">
        <location>
            <begin position="9"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="5">
        <location>
            <begin position="210"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="14"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="3">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC72225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="33944" checksum="4A1D7E5F73A5C66D" modified="2024-07-24" version="1">MSVLQPIRKAAIIGAGQMGLGIAYVSAVHAKIPITIHDPSSSVLSSALDKYKSLISRDVSKSRLTQEQADEALGKFSIVQGDGSGEGIGEPLKDDVDLVIEAIPEIPELKLGLFKRLGRILPSTTILGSNTSSISITKLSASAGSNLSGDEDRKKSSERVIGIHYFNPVPQMKLVEIIPALQTSQNTIDRSKAFGKACKKEVTTSSDSPGFIANAILMPMINEAIIVLEKGIATPEDIDTTFRLGMGHPMGPLTLADLIGLDTCLNIQKVLHNEFGDSKYRPSNLLIKMVDAGWIGKKIRKGFYEYDENGNKILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LB80</accession>
    <name>A0AAJ8LB80_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_107591</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_070203551.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="30174293"/>
    <dbReference type="KEGG" id="kpin:30174293"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Ribonucl_Kappa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026770">
        <property type="entry name" value="RNase_K"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31733">
        <property type="entry name" value="RIBONUCLEASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="V-ATPase_su_f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC73619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="89" mass="9517" checksum="2CBC73F1D47DFDC0" modified="2024-07-24" version="1">MPINVRPVVGPGLAGCCTIFSILGIVILLALGSFFGRHVEGLTGSTKDPKDPDHVAKMCYAAAIIYGAFIVFCGLQMAVHRRYPRGVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LC50</accession>
    <name>A0AAJ8LC50_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_106911</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKN1/KRE6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC72947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009982.2">
        <property type="nucleotide sequence ID" value="XM_019157264.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LC50"/>
    <dbReference type="GeneID" id="30173913"/>
    <dbReference type="KEGG" id="kpin:30173913"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02180">
        <property type="entry name" value="GH16_fungal_KRE6_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000259">
        <property type="entry name" value="Chromosome 9, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF1">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="11">
        <location>
            <begin position="448"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="95"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="174"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="224"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC72947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="871" mass="95738" checksum="72692826F20ACE07" modified="2024-07-24" version="1">MAPSYPWRRTQPSASSSSSNSDQQNQRNGNATPTQRTINEGRSRVISATGIQDSPALNRLEGGLGVGVDSPSILRSRIASPRYSNTITQSNIESFQNENDNYPSPINSLKKGKSKGGWIELKDNNTPSPKENLKKEIQIDGLPIPRYDSRGYPSKNNYEDQYLAYKKNDLGLKTSNSQESLHSNSSEVSSTGAGVNEETSNFLSTGHANKQSYYIPQYSTSSGSVIGSSSSSSHNQGPSPTNSYPPNLDYSLSSISYKPYDDNHSGIVGNTNPLPSLYGDSRVSLNSLGSGESSSAAHFRQHDQLKYLEHGINSDSRGYGYSNFSISSKGGKKHLADMFSLPADPATWSNLGPEPDDDFHDPDYRPANKSHFRAAIFTWRGAANLGCLAAMLLVLVILFAGYPILDNYLSTKIQSHGAYNLGGINATGQIPDIGAFQLIDKDTPQSAYTWQSLETGDEWELIFSDEFNREGRTFFDGDDPYWEAVDLHYWQTNNLEWYDPRMVTTKNGSLEITLDKVATNGMNYTGAMISTWNRLCFTGGYVEASVSLPGTSNVYGLWPAIWSMGNLGRAGYGGSLDGMWPYSYDSCDVGTLPNQTLNGEPTLTTTDGDPNYDNSLSYLPGQRLSRCTCSDDTTHPGPKLANGTFRGRSAPEIDMFEATVDSTLLEGEVSQSGQWAPYNPHYYFLNTSSQYYEIYDSDVTKINTYMGSVYQQATSGLSVTDQNCYTQNTGCFSAYGFEYSPGADGYITWVSNAKKAWTVRGAAMGPNADAKVGQRLVSEEPMYLIMNLGISENFGAVDFDGLEKLWPVKMQVDYIRVYQDPNARNIGCDPENMPTAKYISLYPEAYNDPNITVMSGIPNFTMPKNSLVDTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MLL1</accession>
    <name>A0AAJ8MLL1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_100085</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019015155.2">
        <property type="nucleotide sequence ID" value="XM_019153017.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MLL1"/>
    <dbReference type="GeneID" id="30169612"/>
    <dbReference type="KEGG" id="kpin:30169612"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000003">
        <property type="entry name" value="membrane-associated progesterone receptor component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF115">
        <property type="entry name" value="BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="4">
        <location>
            <begin position="89"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="56"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC66184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="186" mass="19728" checksum="BD380EFACBDF2DD7" modified="2024-07-24" version="1">MSNSSNSGSWYETLTSTPILIATAVGVSFAAIFAVSSSNKTSEQIKTQVKEVTNVASSNTDARGKAAQAGASIMSAPSTDLAPPKDDPISASSLSQYDGSDPSKPIYVAIKGRVFDVTPKAEMYGKGKGYNIFAGRDASKGLGMSSLNLEDAISDYSSLNETQMNTLNQWESFFEKRYNIVGKVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MN89</accession>
    <name>A0AAJ8MN89_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">galacturonan 1,4-alpha-galacturonidase</fullName>
            <ecNumber evidence="12">3.2.1.67</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Galacturan 1,4-alpha-galacturonidase C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Poly(1,4-alpha-D-galacturonide)galacturonohydrolase C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">I206_101493</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl](n) + H2O = alpha-D-galacturonate + [(1-&gt;4)-alpha-D-galacturonosyl](n-1)</text>
            <dbReference type="Rhea" id="RHEA:14117"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14572"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58658"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.2.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.67" evidence="12"/>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058497.1">
        <property type="nucleotide sequence ID" value="XM_070202396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MN89"/>
    <dbReference type="GeneID" id="30174903"/>
    <dbReference type="KEGG" id="kpin:30174903"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047911">
        <property type="term" value="F:galacturan 1,4-alpha-galacturonidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF11">
        <property type="entry name" value="EXOPOLYGALACTURONASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 16" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042612548" description="galacturonan 1,4-alpha-galacturonidase" evidence="17">
        <location>
            <begin position="20"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="WWC67583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="430" mass="46419" checksum="119D4254F3B97BC6" modified="2024-07-24" version="1">MLRYTALFTSILAGAIVSAQQICVVPFGGYGVNDVDGLTALLPNCSSDATIVFQDGVKYNISTPVDFGTLNNVEIQVLGNLELPKSIPYVQQLVNATAGGRLYWFTMKGNNITLSGNPDQSSEYGWVDSYGIQWWQEAQYTQPLGGLANRPHGWSIAANSSTIRNVKLRKPIAWSFSLNGNDMHVYGNKIDAAYDLNNPGVFPFNTDGYDIHGDNVLFENNWVFNGDDCVAVNAGNNITIRNMVCEGGHGASLSATTGVDNVVFDNITSINSLYATRFKSSLNSVGNISNVTWQNIHVHNATFPIFATGVYYDQNTNRGRTPGVYPANSTATHIKNFSWINVTGTISDVYTGDGSCTTDPCWYYVANATNTAGITLQLLNGTATNIQIHNVNLKPIDGKGVSNVVCDPSSFTDGTGNLGFECVNGPYVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MQ49</accession>
    <name>A0AAJ8MQ49_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_103506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058882.1">
        <property type="nucleotide sequence ID" value="XM_070202781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MQ49"/>
    <dbReference type="GeneID" id="30169859"/>
    <dbReference type="KEGG" id="kpin:30169859"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC69563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="912" mass="102238" checksum="826A4E4E68B9D964" modified="2024-07-24" version="1">MLAARSIRQSSRFHRGLSTIGNDIFPHAESSSAPSRRRQYASSAEATVVSDQTGEISSASPLEGTYQSRSKRNIKSNPKAKQAFLRARKLAEAIRSEKEGNSAQISRIKTSTNVEKAQNGDSNFWSDLLNKPTTIDTSSQQTVNTNSSPTLDDLLSKKPDREPPDPWHPKYPQLYRKVYESLDSAFVHRQLKSFSTQLGIYHNAKASKGGMIKKIMKSWKWVEPRNKPKDPDPFVFDLPPPELFLFVRQEELIQSLMDGYERLNMSILPFSEVPQPSSIMLTPNEGDPNRKVLVASGKLEPLMRLSQIISDQKQTLQNVTISSGEINQLKASDGLLRMVSNASGAYVESLPENKYRITAKSSEDIESAKQLLGIASLHSEILPSYRSLDVLLPTPRNFQTQPLRLSLYPFTPSLTESFPWTILPSIASKTLFRLKKVTEWNSKPAIREIDQKNEKIHIAPYLSFSSKNKADIIENIPKTKKQPYFPMNPEELEEEEAERRKGETEFQNLIMDLTAKKGKKRLKLQFGNLLFPIQPKDGRLGTFDNPLPGLWPIETLKNWLIPSHAGNSMVNSTIKPDKKPIFTPSLTPSMIQFPLIEGQSKELRRIRYRSIPSSPTPADSPSSESRFVEFTYTKERTREEKWQDQYDAALNKLEKAILEEEQTIGQEQSITPDEQIIQGSAEEVESHSSTSLFSKQTSAINEGSPEVSEALTSVDEVESISSTTPEVGSAEPDISYTKTFEAVFGVIKESDLLIPDRPNDVRITSTSTVTLPENKIPEAISAIFEAEKEGKLSSSLLPPSKVNIKDEEYTLEYDERVEMIEEAKDIEIAGNTLTLFRRSMRVIEQGMEGKSKPLVYSELECGSTSYGTLPIEFYRELAFMTRDVGPDAGALKRGNILSAFGGSAGWNGMTGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MQB5</accession>
    <name>A0AAJ8MQB5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_105945</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAP domain-containing ribonucleoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC71986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010300.2">
        <property type="nucleotide sequence ID" value="XM_019156498.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MQB5"/>
    <dbReference type="GeneID" id="30173137"/>
    <dbReference type="KEGG" id="kpin:30173137"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052240">
        <property type="entry name" value="SAP_domain_ribonucleoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551:SF1">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="4">
        <location>
            <begin position="5"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="44"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00046328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC71986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="251" mass="26798" checksum="5D7A4B0EDE4CAFB3" modified="2024-07-24" version="1">MEAKLQKLKVTELKELLAKHHLVQTGKKDDLVKRLLDNNVTVDDEPAEELVDPDATTSTVASELTSAPIAQQTEASSSKSPAQAEPSTTTEELTPEQKAMKARAERFGIPFNPNPPPKTNKPKSTLATNGKAAAAPSSTKTEAPAKKEKAGAIDSTNLGISQDILDKRAAKFGIPEKKEQASAPSPVPAPVSTASAKATKPESKKKEEISPEMAEKIAVEEEKKRKRAEKFGLTKSADANGSEPDTKKVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MR03</accession>
    <name>A0AAJ8MR03_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_105209</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
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        <text evidence="8">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS2 family.</text>
    </comment>
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        <property type="protein sequence ID" value="WWC71256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_070203082.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="kpin:30172251"/>
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        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009582">
        <property type="entry name" value="Spc2/SPCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 25 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06703">
        <property type="entry name" value="SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="158"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="158"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007324"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00017057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00045608"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC71256.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="352" mass="40253" checksum="515EB406A15FD2A6" modified="2024-07-24" version="1">MAPTKRATNSGSSVTTSLGAPIKTDLINETDLSTLATDPLPTITVNNANLGEIKAALDDIVKKHLQDQSFTPSILHPTVHLLLGYSSIILALSSILYSLKVEFEDSKPILWISVIGYTILQTILWSWKRWIEKGEVFKGKRRRMVKRIETDHIQIISSTSLNSPPLPNLSFSPHIHTSRPSSPNSPISPNLDLNQKNFEQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQIPNLTKFNEIEIIENKKGPSYILQITLIITSNNGKSLIHKSKLIIGKLISNLIDEKGGIEKGQIIRWLSNVLNEIGLKSSLDEIND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HSG5</accession>
    <name>A0A1B9HSG5_9TREE</name>
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        <recommendedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_07891</name>
        <name evidence="3" type="ORF">I206_100076</name>
    </gene>
    <organism evidence="2">
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        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700119">
        <property type="protein sequence ID" value="OCF46220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="kpin:30176260"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628079" description="Ig-like domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF46220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC66175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="27493" checksum="1477E578FEA46A99" modified="2016-11-02" version="1">MFNNIIISLPLAFAILGLSSAAVDPVCANGPGALAENFHGCPDTSANGDGLIGVEIISIAINNIIQLQCLYPPPSDGTSQYSYECNYQATGTIDDGILSFHPRSDNSDNCRNYNFQGTPNPMSSPAPQAVTKRDTLYDRPIYRCSETNNDNSGTAYGADQTNVYRGSYQTTIYGDVVSYACAYRNRPARTYSICYYNDAGTLYHSSLNGFPDCPNLCSITYPDRRRNDHPRIRNNQARLKKRLALPQPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HSQ7</accession>
    <name>A0A1B9HSQ7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_07800</name>
        <name evidence="3" type="ORF">I206_103847</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="Shea T."/>
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                <person name="Heitman J."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Griggs A."/>
                <person name="Gujja S."/>
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                <person name="Imamovic A."/>
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                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Goldberg J."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
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                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="Heitman J."/>
                <person name="Sun S."/>
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    <reference evidence="15" key="2">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="Heitman J."/>
                <person name="Chen Y."/>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="David-Palma M."/>
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                <person name="Bowers K."/>
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                <person name="Mohammad A.W."/>
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                <person name="Yurkov A.M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        <text evidence="2 11">Belongs to the MCM family.</text>
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    <dbReference type="AlphaFoldDB" id="A0A1B9HTD2"/>
    <dbReference type="STRING" id="1296096.A0A1B9HTD2"/>
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    <dbReference type="KEGG" id="kpin:30175749"/>
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    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17755">
        <property type="entry name" value="MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000217">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008047">
        <property type="entry name" value="MCM_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF66">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21128">
        <property type="entry name" value="WHD_MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01660">
        <property type="entry name" value="MCMPROTEIN4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="592"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="526"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="28"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCF46527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WWC72768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1010" mass="111016" checksum="8BDE5F7B9BAF1126" modified="2016-11-02" version="1">MSTPNPPRSSSPLNFPSSSVAGTPKASRLSTNARNAPPGSSSPLHFPTSSPRHPSSTGRRVPSGLGSDAIPSSSGLRRVRGETPLFFPASGGSTPRRQRRGDIHSSFPLSSPSLARRTVQNTPLLVRGSSPSHTDTDIDIDGEGADPTTPRASRRHEAGSSAPTLSAIAPSQDGVYGIGTGGGGGEEGEDEGGIVKFIWGTTISLQQSMNMFRDFLRGFKIKYRTIYNSEINKNIMENGGIVPPSQPLYDNSLTKGEVLLYENYLKKLQLTGETNLNLDSLNLLSFPPTKKLYYQLMNFPQEVIPIMDQVLRDTMIEFSEEEFELAQRKYTEGELDKLELDLLQDELNQIQGKVYKVRPFGGERSVNMRDLNPGDTDKLVSVKGLVIRATPVIPDMTAAFFRCMVCQHTVQADIDRGKINEPERCPRDVCSLKGTMSLIHNRSEFTDKQVIRLQETPDAVPDGQTPHTVSLCVYDELVDLVKPGDRVIITGIFRSIPVRVNPRQRSIKSLFKTYLDVVHIKRTNTGRMGYDPSTRNGEGKPPGVGVGGEDDEEELLSHPEAPMDLQDNEESNLTTSAEMEQKLTELSNNPEVYEILARSMAPSIYELEDVKKGILLQLFGGTNKSIARGGGGGGPRYRGDINVLMVGDPGTSKSQILQYVHKIAPRGVYTSGKGSSAVGLTAYVTRDPDSKQLVLESGALVLSDGGVCCIDEFDKMSDATRSVLHEVMEQQTVSIAKAGIITTLNARTSILAAANPINSRYDPKLPIPANIDLPPTLISRFDLLYLVLDRVDELNDRRLAKHLVGLYLEDRPDTAGEDIIPLETLTAYITYARSRIHPVLSEDASTALVQAYVEMRKAGVDTRTQEKRITATTRQLESMIRLSEAHARMRFSERVELRDVMEAVRLIKSALRESATDPLTGQIDLDLLNIGTGSSTRKARSDLKKEILQLIDNSGNRGLKWSSVIKGLEQQSSLPIDHSEFSEVVKSLTDEGILKVVGEREKRTIRRLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HTM8</accession>
    <name>A0A1B9HTM8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Signal recognition particle receptor subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_07481</name>
        <name evidence="12" type="ORF">I206_106628</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP-binding SRP family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894016">
        <property type="protein sequence ID" value="OCF46628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007847.1">
        <property type="nucleotide sequence ID" value="XM_019159175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HTM8"/>
    <dbReference type="STRING" id="1296096.A0A1B9HTM8"/>
    <dbReference type="GeneID" id="30175850"/>
    <dbReference type="KEGG" id="kpin:30175850"/>
    <dbReference type="OrthoDB" id="1727884at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005785">
        <property type="term" value="C:signal recognition particle receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14826">
        <property type="entry name" value="SR_alpha_SRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17876">
        <property type="entry name" value="SRalpha_C"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="10">
        <location>
            <begin position="638"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="313"/>
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            <begin position="170"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
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            <begin position="203"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
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            <begin position="220"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF46628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC72664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="665" mass="72051" checksum="58C589CCAD10695D" modified="2016-11-02" version="1">MLDHVSISHQSGLILWSRSFTPAFASLAQSSASPVNALIKEAFIEGKARNEEEGYEKDGYSVRWTMENGLGLVFVVVFPALLPLTYIPELLQRTKQLFVSLFQPYLQSLIDSLTAGTLVLSTASVTALQTLKERIEEDRWAAIFDRCLKSLEGTRKPARTPVNLHRQAQLNAASDASTPALSDTENTPVTAEEIAKNVQALKSKMKGGRAKGGRGGRGEGLSPSPSPSRKTSNNASAKLMRKWGDSQISVDDMAALDFSAPADENASVDTEGLVSNEALGVRNASGAYEVADWDYKRSKEDDLPSEEEILSRRTSGLAIKPSADEDTAESSHWSNMFSRLTGKKTLTQEDLKPVLVEMERHLMSKNVAKDISEKMCESVGAALVGKKLGGLNSVKSEVQNALSISLTRVLTPKTSTDILLEIQRKRTASSLASPDAPRDPYALTFVGVNGVGKSTNLSKVCFWLLQNGLRVLIAACDTFRSGAVEQLRVHVRNLGALGSEMGMDEEGGNKKIELFERGYGKDAAGIAKDAIAYAKENKFDVVLIDTAGRMQDNEPLMRALAKLVAVNNPDKIIFVGEALVGNEAVDQLSKFDRSLKDFSSAGGSQKKRGIDGIILTKFDTIDDKVGAALSMTYVTGQPILFVGCGQTYTDLRQLKVNHIVQALLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HU85</accession>
    <name>A0A1B9HU85_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_07215</name>
        <name evidence="4" type="ORF">I206_106411</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894015">
        <property type="protein sequence ID" value="OCF46828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008047.1">
        <property type="nucleotide sequence ID" value="XM_019158909.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="30175584"/>
    <dbReference type="KEGG" id="kpin:30175584"/>
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        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="199"/>
        </location>
    </feature>
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        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF46828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC72449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="327" mass="36451" checksum="44580AE74884D9A4" modified="2016-11-02" version="1">MESDKQHSNPGVNNVIDDEWADRWLNEAFQEMNDESASGQNGNGGWTANYGGHQQAQVEDTFHDTNPNFDPNQLTIYPAYSGEQANDPLYNSYLGYRSSANSFDFPPYVPPFSVDDANMSSARNSANGLPSGVEASNFTQRVSNDQASFIDQGHDGNQGHDDPQDSANTPHALIQETPDSSGNDNDVSTAEYGVSTTAGRISSKRIEEVLRSIRRNEKQVEELRSKIATKEKISEDDSSITFLAKDPTTNIKLPTAPDRLYYPEDKAEEDRLRALARDSRACADRPIPADDNLDYASERERTVYCACVSKELTLKRLRKELKVRLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HUF4</accession>
    <name>A0A1B9HUF4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="13">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">I206_07280</name>
        <name evidence="19" type="ORF">I206_106475</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="13"/>
    <dbReference type="EMBL" id="KI894015">
        <property type="protein sequence ID" value="OCF46893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008112.1">
        <property type="nucleotide sequence ID" value="XM_019158974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HUF4"/>
    <dbReference type="STRING" id="1296096.A0A1B9HUF4"/>
    <dbReference type="GeneID" id="30175649"/>
    <dbReference type="KEGG" id="kpin:30175649"/>
    <dbReference type="OrthoDB" id="10262986at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18029">
        <property type="entry name" value="DEXHc_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18789">
        <property type="entry name" value="SF2_C_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000077">
        <property type="entry name" value="Probable DNA repair helicase RAD25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000117">
        <property type="entry name" value="Putative DNA repair helicase rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050615">
        <property type="entry name" value="ATP-dep_DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001161">
        <property type="entry name" value="XPB/Ssl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00603">
        <property type="entry name" value="rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274">
        <property type="entry name" value="RAD25/XP-B DNA REPAIR HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00851">
        <property type="entry name" value="XRODRMPGMNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="375"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="591"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="835"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OCF46893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="WWC72513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="874" mass="97708" checksum="61A8E09008E73A43" modified="2016-11-02" version="1">MSRSQSPASSLDFFESEPSSGEEEYVPRPRRKVGPAAGGSKKVLGGPKAGGPKIKINLRALQSARDVGAAHPADGPIEEDDIGEAEEDDEGYFDGMIGKRGIDLSNQPLKADHGLRPLWVDDKGNIIVEAFAPFAKQAQDFLVAIAEPVSRPSLVHEYRITKPSLHSAMSIGLETKVIIEVLSRLSKTPLSMKLTARIEEWTASFGKVRLVLKDNRYFLETSVPEFLQTLMTDEVIRDCRVTREVEAGPTVFGAEQTARPRRDYAIPGTEEARRAERGEIEADAIGQQNRDNDALLGAVIGIGEADEMDDEDDAVHSFEVSGERMEEVRRRCKDIDLPALEEYDFRNDTVNPNLDIQLKPMTVIRPYQEMSLAKMFGNGRARSGVIVLPCGAGKTLVGITAACTIKKSALVLCTSAVSVAQWKQQFLHFSNISERQICAFTQGEKEMFTTPAGIVISTYSMIAKTGKRAHDAEKMMQFLRSREWGFLLLDEVHVAPADMFRKCINNFKVHAKLGLTATLVREDDRIGDLGYLIGPKLYEANWMDLAKNGHIATVQCAEVWCPMTPEFYREYLRNPSRKRILLHAMNPNKIQAAQFLINYHESRGDKVIVFSDNVFALEAYAKKLGKSFIHGGTPEGERLRILSRFQHDPQLNTIFLSKVGDTSIDLPEATCLIQISSHFGSRRQEAQRLGRILRAKRRNDEGFNAFFYSLVSKDTQEMYYSSKRQGFLIDQGYAFKVITELHGLESMPNLVFPTKAQQISLLEEVLNTGDAAAETADHYMRLNNGKHMKRPAGTQPALSNSGAMPAVQRFTAPLEHLSGGQNLSYREQNKSVNKEYMREDRQNKRAGVSGKDQHSLFKKRKQEMDAIKKQRGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HUT4</accession>
    <name>A0A1B9HUT4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">I206_06804</name>
        <name evidence="19" type="ORF">I206_102103</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="KV700117">
        <property type="protein sequence ID" value="OCF47030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC68180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008249.1">
        <property type="nucleotide sequence ID" value="XM_019158503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HUT4"/>
    <dbReference type="STRING" id="1296096.A0A1B9HUT4"/>
    <dbReference type="GeneID" id="30175173"/>
    <dbReference type="KEGG" id="kpin:30175173"/>
    <dbReference type="OrthoDB" id="238316at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2330:FF:000002">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000028">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040725">
        <property type="entry name" value="PheRS_DBD3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003210">
        <property type="entry name" value="PRK04172.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF40">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18553">
        <property type="entry name" value="PheRS_DBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 18" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="17">
        <location>
            <begin position="241"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OCF47030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="WWC68180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="513" mass="57861" checksum="075F3376267EDD66" modified="2016-11-02" version="1">MSSPTPESIQSLILQTLSTSNTIPDSRELSIDGQTLNTSEDQNAIRGVLDSLQRKEMVEYKQITATSFTLTEEGQLINEKGSHEIRVWQVLPVKGQGEPITVPDLQKLVGADVAKIGQSNAFKKKWISKDGPGFVRAVEQPPKDETAEQLKEISSTGNLKIAGSENAIKELQKRKLILPKKHIHYSVTKGPQFSTEVKQLETDLTVEMLQSGAWKESSFKTYNFAAAGQPTDGGALHPLLKVREEFRNIFFDMGFTEMPTNQFVESAFWNFDAMFVPQQHPAREVQDTFYVKSPVKALQPDPEYYERVRKIHEEGGYGSIGYRAPFSREESEKLLLRTHTTAVSTAMLYELANQPGGFKPAKMYSIDRVFRNEAMDATHLAEFHQVEGVVADYNITLGHLIAFMQEFFAKTGNHKLRFKPAYNPYTEPSMEVFSWHEGLGKWIEIANSGIFRPEMLEPMGLPKGVRVLGWGMSLERPTMIKYKIGDIRTLVGHKTDLDQVKKRAAVRLEKGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HV22</accession>
    <name>A0A1B9HV22_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">50S small subunit ribosomal protein L4e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_06889</name>
        <name evidence="6" type="ORF">I206_102019</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700117">
        <property type="protein sequence ID" value="OCF47113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC68098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008332.1">
        <property type="nucleotide sequence ID" value="XM_019158586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HV22"/>
    <dbReference type="STRING" id="1296096.A0A1B9HV22"/>
    <dbReference type="GeneID" id="30175258"/>
    <dbReference type="KEGG" id="kpin:30175258"/>
    <dbReference type="OrthoDB" id="10259785at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1370.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025755">
        <property type="entry name" value="Ribos_uL4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013000">
        <property type="entry name" value="Ribosomal_uL4_euk/arc_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045240">
        <property type="entry name" value="Ribosomal_uL4_euk/arch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19431">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14374">
        <property type="entry name" value="Ribos_L4_asso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00939">
        <property type="entry name" value="RIBOSOMAL_L1E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL4 C-terminal" evidence="4">
        <location>
            <begin position="266"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF47113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC68098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="363" mass="39584" checksum="7F1485F94DE2380B" modified="2016-11-02" version="1">MAARPTVTVWSATGESSGSVPLPAVFTAPIRLDVVQQVHKSIAKNRRQPYAVAENAGHQTSAESWGTGRAVARIPRVGGGGTQRSGQAAFGNMCRGGRMFAPTKTWRKWHVKVNQNQRRYAVASALAASALPSLVLARGHRIEQIQEVPLVISSSVESVTKTKEAVELLKATAAYADIAKVSNSRKLRAGKGKLRNRRYRQRRGPLVVYAKDEGLTRAFKNVPGVETCPVESLNLLQLAPGGHVGRFIIWTESAIAALDSVYEKKSGFNIPTAKISSSDVTRLINSDEIQSVLRPAGAPTQKRPFTQKKNPLRNKAILFRLNPYAKTLRRQELLRQEKKSKGSVKKSAPAAAGKEFLEILHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HV32</accession>
    <name>A0A1B9HV32_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rab family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_06910</name>
        <name evidence="4" type="ORF">I206_101997</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
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            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
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        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
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            <end position="200"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC68078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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    </evidence>
    <sequence length="200" mass="22138" checksum="1F9BF99B7EDD36EC" modified="2016-11-02" version="1">MSRTTSFKLVLLGESAVGKSSLVLRFVRNEFSDFRESTIAAFLTQTVSLDDSTSIKFEIWDTAGQERYKSLAPIYFRNSNAAVIVYDITQASFEKARSWVRELQRQADPSIVIMLVGNKLDLESQRKTPREMGERFAQEEGLLFAEASAKSGDGVEGLFMDIAKKLPLAPPPTRSTQTGPRGVKVANEQEESTTPSACTC</sequence>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">CBS 10737</strain>
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    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="OCF47155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC68057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019158628.1"/>
    </dbReference>
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        <location>
            <begin position="1"/>
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        </location>
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        <location>
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    </feature>
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        </location>
    </feature>
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        <location>
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            <begin position="756"/>
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        </location>
    </feature>
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    </feature>
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            <begin position="118"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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        <location>
            <begin position="597"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="765"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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        <source>
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</entry>
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        <name evidence="3" type="ORF">I206_101777</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="kpin:30174620"/>
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    </evidence>
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<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
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            <taxon>Agaricomycotina</taxon>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
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        <text evidence="3">Required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis.</text>
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        <subcellularLocation>
            <location evidence="3">Endosome</location>
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            <topology evidence="3">Peripheral membrane protein</topology>
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    </comment>
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        <text evidence="3">Belongs to the MON1/SAND family.</text>
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    <dbReference type="STRING" id="1296096.A0A1B9HVZ8"/>
    <dbReference type="GeneID" id="30174714"/>
    <dbReference type="KEGG" id="kpin:30174714"/>
    <dbReference type="OrthoDB" id="272411at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
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    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:Mon1-Ccz1 complex"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="InterPro" id="IPR004353">
        <property type="entry name" value="Mon1"/>
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        <property type="entry name" value="SAND PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027:SF7">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01546">
        <property type="entry name" value="YEAST73DUF"/>
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    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
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        <location>
            <begin position="253"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 second Longin" evidence="6">
        <location>
            <begin position="414"/>
            <end position="509"/>
        </location>
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            <end position="644"/>
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    </evidence>
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            <dbReference type="Pfam" id="PF19038"/>
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    </evidence>
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            <dbReference type="EMBL" id="OCF47444.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC67775.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="655" mass="73171" checksum="B06ED139868CCE85" modified="2016-11-02" version="1">MPSSPPSSSYVELPSSSSNTQVITQSSGIPSFPPTPSRTTSKLSITSVDAHLSPPTETDRRRRSHSNPNIRAKSPTPSTPTKYSKRSQNGLLNVDPFSGAMTVRTKSSVSTAASSMKSVSVFDGVHTTPSPSSGDGTPTSGLSKNFDNLVIKQYDDSEVRASQSKKGKEKALDIDVMEEEGAEGEMSRSTSDVRKGLRNLVRRDTEQKHLDKTTGDQKMIPRQGLKDTKDDPHILNITQSSANHVIRYTARRYYVLTNAGKPVFSSHDDSSEDNITNLMAIASTLISIFQEDDDKIRSIVKGNSRIGFVLKSPLYLFAISDWGEPEHVLRSHLEYIHLQILSVVSSTQLSRVFQRRSNFDLTRLLEGTETFLHKLIDHSQFDFSYLTATLQPLRMNPATRDVAGAALMPPSKFKDLLYVLLIADGRIVTLLRPRKHAVHPSDLHLLLNTLASSATLRSSETWLPICFPKFNPAGFVHAYISYMTEDVGLVFVSADRDAFEDLRQWKSIVLEKLEVDRTLSKISDAIPLHPYTVSAIGCPGLLHFIYKSRQYIQITQPEWEAPYVEDSIDRKRLITLYQKLHDVVHARSGQSETYKLVYMRTEHEACLAWLTKPFELYLTVSPQLSKSAVVSTANTVAKWVLAEEGRVFLKDAPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HW79</accession>
    <name>A0A1B9HW79_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">STE/STE11 protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_06438</name>
        <name evidence="11" type="ORF">I206_101592</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008756.1">
        <property type="nucleotide sequence ID" value="XM_019158143.1"/>
    </dbReference>
    <dbReference type="STRING" id="1296096.A0A1B9HW79"/>
    <dbReference type="GeneID" id="30174807"/>
    <dbReference type="KEGG" id="kpin:30174807"/>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09534">
        <property type="entry name" value="SAM_Ste11_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000334">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000387">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029458">
        <property type="entry name" value="Ras-bd_By2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF56">
        <property type="entry name" value="MAPKK KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14847">
        <property type="entry name" value="Ras_bdg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01304">
        <property type="entry name" value="Ras_bdg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM" evidence="9">
        <location>
            <begin position="104"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="1074"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="168"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="507"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="775"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="10"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="258"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="350"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="375"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="402"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="419"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="511"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="788"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="822"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="902"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1007"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="1103"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF47537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC67680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1384" mass="150097" checksum="6B804A732289C2C7" modified="2016-11-02" version="1">MTSLSSTLRPQPITHSPTSSISSQNTTPTSPHFAQHASAATSRHPYASAHHLEPRPRHQSSSNSISTTATSSSSVNIIHHPRPPTPPLLHAPPSTSYMTYLRGWGQAELTAFLNLYRCGQYAAAFQRHDIDGKVLLDLDMAALKEIGIAKVGERVKLLGGIKDLRKRAAGSRDSLRSSVRSGSVGSVATPPSETTEHMISPSLPDTIRSQSRLVHPSSSSSLSTSSSRRLNTSRPPPLDLQQYKSSRPLPQAYQNNLPSATSYRSTTTTPRPIPPLQQSLPSRPVLLAQSSSNTTVTPSNTNSSSVPAPSNPKQLSLRPPPSRDPSRRSPSPINVDSSNFASRPLPPDPSASYQSSAAEYASAFTQQHQHKQGENGKQTPTWASSSDHQYGLPKGPAPGSGSKVTATRINESTQHRKTPSVSQTGGTTPKQSSPIKGKFGNIMGNLGGRSTPQHPFAANRSREELVLERQNSDILSASTGNLAAKRSVTPTPGYVVGRTVSSERVRQKTGNESLASTNTLSSNNSRIAPSLDDLRRQLVKFVNSEDGTMRTVNVMHVTSGVEVLERALKKFGKWGTGTHVNTDTESDEDGERLEVDGWGVYAESDPDNDSKPLSEAALLGICLSHRDGSAMREKGLTLRRTRKLQNRKNMNNYLGEAPPQPMSPTSPTPFSGPRYGEHSNLLTPIKSAASKKMNRASTVSVMSGLGVPMPEVPPSPSTTRSPSSASFLSNKKKSVYNFFGHRPPSELISNHLAEYFPSAKKKDVEKARHSMLRMSSGPGALKRGSLAPSESTGRLSFDSTFAPSIKRSSVRIADPMAEVKASPPRRSTRPGSRGTMISSPPPAGTIPEEEFEILGDEHPPRLSVSNDDGRLSRPTIDGESDVESLGSSASQGPPLLPPFQHSGESLTESLGDYSPTQKGNNNNRPKSIALKRRGSEESTRSRFSMLSQLRKNRDKSDTASMLTIDEITAGVENRRASTITFNDSDEEDEEVIIPAPPLIMPTLPQDQNEEGNSDGDNESETTETEEESTEEEEDEEEEETETETESEDDDDDDDEDNEHGKAFTSTGSKRIIKWIKGALIGAGSFGSVFLGMDAHSGLLMAVKQVELPTGSARNEERKQSMVSALEREIELLKELQHENIVQYLDSSADGNHLNIFLEYVPGGSVAALLSNYGAFEEALVKNFVRQILTGLNYLHEREIIHRDIKGANILVDNKGGIKISDFGISKKVESNLMTGPKTNRPSLQGSVFWMAPEIVKQTSYTSKADIWSVGCLIVEMLIGSHPYPNLTQMQAIFRIGSQTPVPEIPPDISNEAADFLKQTFEIDHNSRPTAFQLLQHPFIALPTSSSNKNSSRNNNIISMADAHKRMSMAMANAGQGLGGLMSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HW97</accession>
    <name>A0A1B9HW97_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_06430</name>
        <name evidence="4" type="ORF">I206_101600</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008748.1">
        <property type="nucleotide sequence ID" value="XM_019158135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HW97"/>
    <dbReference type="GeneID" id="30174799"/>
    <dbReference type="KEGG" id="kpin:30174799"/>
    <dbReference type="OrthoDB" id="2595605at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF47529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC67688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="247" mass="28113" checksum="4B3BEC5F2C63F45E" modified="2016-11-02" version="1">MSTSNSNLPFGLSKIFKPITPKIIAKTKLKSNLFLLFLFKIIFLFFPPYLNLKLLLIKIIDKFIQNRKNLREISYSENVFYYFEFLITSVLIFNIIESFISIQYPINYSPEIKQNLILTPSKLSSPLTRSYSPSKIPTTSSQTLQRSIYKSSPISTPIKSSSNQNQNLNISQSSPNSKSPTTVKLFKLSSSSSSSIKNQSPSKSGLFFEEKDKNQQNDNFILIDREEKLWVDNVLKGVRGKSGKIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HWD8</accession>
    <name>A0A1B9HWD8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_06489</name>
        <name evidence="13" type="ORF">I206_101539</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008805.1">
        <property type="nucleotide sequence ID" value="XM_019158192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HWD8"/>
    <dbReference type="STRING" id="1296096.A0A1B9HWD8"/>
    <dbReference type="GeneID" id="30174858"/>
    <dbReference type="KEGG" id="kpin:30174858"/>
    <dbReference type="OrthoDB" id="10265467at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000731">
        <property type="term" value="P:DNA synthesis involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18139">
        <property type="entry name" value="HLD_clamp_RarA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000345">
        <property type="entry name" value="AAA family ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000001">
        <property type="entry name" value="Putative AAA family ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3710.10:FF:000004">
        <property type="entry name" value="Putative ATPase, AAA family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3710.10">
        <property type="entry name" value="DNA polymerase III clamp loader subunits, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051314">
        <property type="entry name" value="AAA_ATPase_RarA/MGS1/WRNIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779:SF7">
        <property type="entry name" value="ATPASE WRNIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779">
        <property type="entry name" value="WERNER HELICASE-INTERACTING PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51908">
        <property type="entry name" value="ZF_UBZ4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBZ4-type" evidence="11">
        <location>
            <begin position="5"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="76"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="353"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="353"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51908"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF47586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC67629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="623" mass="68548" checksum="3759C0DB449C1756" modified="2016-11-02" version="1">MSTEKVECPICSTLVSESDINLHLDLQCRGKANIAGPSSTPKLKSQNSQEKGNGTISSPHAEIINLVEDTPTAKPALNARRSSGKSTGPVASIFNTSTKSKRKNLSQDEDPLEDKKPTGVFGEEGRMEKKSKINPLVANQPLAERSRPSTLASYIGQTDLVGPGSLLRARIEAGEGVGSCILWGPPGCGKTTLARLIARTADADFKELSATSSGASDVRQVFEQAKNSLKLTGRRTILMVDEIHRFNKAQQDLFLPYVENGWVQLIGATTENPSFKVNGALLSRCQVFTLSPHTPESLQEILANALSSLPEPLPHLPPDLIPFLADVADGDARQALNGLELALKVCQAPRQTTLSASNSDISQNGGTGVEGEESGDKGEQKQKENEEEQKKRDEELMASVRRGLRKGYDRSGEERYDMISAMHKCLRGSDGSAAMYWLARMITGGEDPLYIARRLVVMSSEDVGLADPQALPLAMATYQACQVIGLPECRINLAHCVAYLAEAPKSTRSYTAYKRAEALCHQPPLPAVPLQIRNAPTKLMKQLGYGKKYSYDPDYIHPVYNEYLPHTLANHSSASPFPEQHILKNPEYELKDKNWDEDRLSEWEWRINNNKEWQGRTMREDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HWL2</accession>
    <name>A0A1B9HWL2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PIG-P domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_06569</name>
        <name evidence="9" type="ORF">I206_101459</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008883.1">
        <property type="nucleotide sequence ID" value="XM_019158270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HWL2"/>
    <dbReference type="STRING" id="1296096.A0A1B9HWL2"/>
    <dbReference type="GeneID" id="30174938"/>
    <dbReference type="KEGG" id="kpin:30174938"/>
    <dbReference type="OrthoDB" id="690928at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052263">
        <property type="entry name" value="GPI_Anchor_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013717">
        <property type="entry name" value="PIG-P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46346">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46346:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08510">
        <property type="entry name" value="PIG-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="PIG-P" evidence="7">
        <location>
            <begin position="55"/>
            <end position="179"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF47664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC67550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HWM8</accession>
    <name>A0A1B9HWM8_9TREE</name>
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        <submittedName>
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    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_06564</name>
        <name evidence="5" type="ORF">I206_101464</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008878.1">
        <property type="nucleotide sequence ID" value="XM_019158265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HWM8"/>
    <dbReference type="STRING" id="1296096.A0A1B9HWM8"/>
    <dbReference type="GeneID" id="30174933"/>
    <dbReference type="KEGG" id="kpin:30174933"/>
    <dbReference type="OrthoDB" id="5973539at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF17">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="26"/>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">CBS 10737</strain>
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    <reference evidence="13" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="12">CBS 10737</strain>
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    <reference evidence="13" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="13">CBS 10737</strain>
        </source>
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        <subcellularLocation>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
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    <reference evidence="19" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 10737</strain>
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                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
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                <person name="Heitman J."/>
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                <person name="Gargeya S."/>
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                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
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                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Mohammad A.W."/>
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            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF47846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC73413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="472" mass="47392" checksum="53DC51BA4C46E163" modified="2016-11-02" version="1">MAQSNPPLNHLRRRNIYPRQDPSSAAAAATTSAEASPTPSVEPSPSASPSIEPSSAAPETSIASATPSPSAEPSTSATPSPSPSPSPSASPSPSVSPSAQPSSQAPQSSAAPSSAQPSPSQSPSATPSPSATPSPSQQSSAVPTSQQQSQSASPSAAPSSQPGGTTTTITVGQSSTVASQAPSTSNGESSQPGTTTSTVIVQPSATSQTTLTSAVGIVTTTDSNGKTTTSVPAEITSSYLTTSDGQVYTKTVVVHNPTGALDNGGKGSSGSTNSFFNNKGAVAGVFVVVGLVVVGLTFALGLLCFRRRRRQRLDREVTAAAIAASSSGPTARSPLDEDNDYHSSAGPTSESYPSTVNQPMTQYGSYGASYAPAGGYDPYAPTAGAGAIAGYGATHSGGYDGLQQGEQGGYYFDPRDAGNYADAPQDEYAPPQQHGQGYNDPYGGYSTGEGSLDTPNQERGDPLHVANPSHRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HXJ4</accession>
    <name>A0A1B9HXJ4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_05837</name>
        <name evidence="9" type="ORF">I206_107509</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="KI894014">
        <property type="protein sequence ID" value="OCF47971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009190.1">
        <property type="nucleotide sequence ID" value="XM_019157550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HXJ4"/>
    <dbReference type="STRING" id="1296096.A0A1B9HXJ4"/>
    <dbReference type="GeneID" id="30174206"/>
    <dbReference type="KEGG" id="kpin:30174206"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF11">
        <property type="entry name" value="AMIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="76"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="230"/>
            <end position="233"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF47971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC73537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="548" mass="59958" checksum="B7E816FF7469AAAB" modified="2016-11-02" version="1">MTLIPSTPWEEISKAKRAARDALIPIDWQIPSTDANNVIDVPRTCGVLSSKEIEITETDAPTLVEKLIKGQLSSYDVTLAFCKRAAVAQQLTNCLTEILFDTALKNAKSIDEEYDRTGTPIGPLHGLPVSLKDNFYIEGVDTTVGFVAWANDPAKKEKESEMTKIMRECGAVLFCKTNVPTAMMIAESYNNVWGYTCNPYNRKCSSGGSSGGESALLALKGSPLGVGTDIGGSIRIPSSFCGLYSLKPSFGRFATYGARSGLPGQEAIKSINGPMSTSLEAVELWAKSVVGAEPWYRDPNMLPIPWREVNIPQKLCFGLIMDNGIVKPTPPVTRALSETKKALEAAGHRVVEWSPYKPEEANTIVNRFFQGDGGVKIAQYIALSGETYPEGLSAYKARYEALKSSPPLVGDLWDTQSDRTAYCKKVLDHWLSSKSVTETGRPFDGIISPVTPFSACPKMAFGGHVAYTSMWNITDYSATTFPVSFVDPTVDLKTPYEARNEVEKEVWDRYDPEEVVGAPISLQLVCQRLEEEKALKLTRVVADALKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HXR6</accession>
    <name>A0A1B9HXR6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein mgr2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_05905</name>
        <name evidence="8" type="ORF">I206_107572</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGR2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894014">
        <property type="protein sequence ID" value="OCF48038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009257.1">
        <property type="nucleotide sequence ID" value="XM_019157617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HXR6"/>
    <dbReference type="STRING" id="1296096.A0A1B9HXR6"/>
    <dbReference type="GeneID" id="30174274"/>
    <dbReference type="KEGG" id="kpin:30174274"/>
    <dbReference type="OrthoDB" id="5409308at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018450">
        <property type="entry name" value="Romo1/Mgr2"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Romo1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Romo1"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCF48038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC73600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="116" mass="12416" checksum="7DFF65B98C3FA27B" modified="2016-11-02" version="1">MPPPPQTVAGGSTFDKMKMGAIMGSCVGLTIGFIFGSFSVLRAGPGPRGLVATLSQYMLSSAATFGFFMSIGSVIRTESQYAYALPPNSPNGIISQPIMMAWKRSEERKKMESARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HY23</accession>
    <name>A0A1B9HY23_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BRCA2 OB1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_06019</name>
        <name evidence="5" type="ORF">I206_107684</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894014">
        <property type="protein sequence ID" value="OCF48151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009370.1">
        <property type="nucleotide sequence ID" value="XM_019157730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HY23"/>
    <dbReference type="STRING" id="1296096.A0A1B9HY23"/>
    <dbReference type="GeneID" id="30174388"/>
    <dbReference type="KEGG" id="kpin:30174388"/>
    <dbReference type="OrthoDB" id="21095at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04493">
        <property type="entry name" value="BRCA2DBD_OB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015525">
        <property type="entry name" value="BRCA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015252">
        <property type="entry name" value="BRCA2_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036315">
        <property type="entry name" value="BRCA2_hlx_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015187">
        <property type="entry name" value="BRCA2_OB_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11289:SF0">
        <property type="entry name" value="BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11289">
        <property type="entry name" value="BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09169">
        <property type="entry name" value="BRCA-2_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09103">
        <property type="entry name" value="BRCA-2_OB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81872">
        <property type="entry name" value="BRCA2 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Breast cancer type 2 susceptibility protein helical" evidence="3">
        <location>
            <begin position="587"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="BRCA2 OB1" evidence="2">
        <location>
            <begin position="640"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
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        <location>
            <begin position="320"/>
            <end position="348"/>
        </location>
    </feature>
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        <location>
            <begin position="404"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF48151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC73712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HYU0</accession>
    <name>A0A1B9HYU0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CASTOR ACT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_05185</name>
        <name evidence="3" type="ORF">I206_107270</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
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                <person name="Heitman J."/>
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            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HZJ7</accession>
    <name>A0A1B9HZJ7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_05438</name>
        <name evidence="6" type="ORF">I206_107019</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIKE family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC73054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019157159.1"/>
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        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008555">
        <property type="entry name" value="SIKE"/>
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    <dbReference type="PANTHER" id="PTHR39472">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39472:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05769">
        <property type="entry name" value="SIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="320"/>
            <end position="384"/>
        </location>
    </feature>
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        <location>
            <begin position="79"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
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        <location>
            <begin position="333"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="369"/>
            <end position="384"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00005537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF48658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC73054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1B9HZQ6_9TREE</name>
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        </recommendedName>
    </protein>
    <gene>
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        <name evidence="19" type="ORF">I206_106959</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 10737</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1 9">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC72995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009937.1">
        <property type="nucleotide sequence ID" value="XM_019157219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HZQ6"/>
    <dbReference type="STRING" id="1296096.A0A1B9HZQ6"/>
    <dbReference type="GeneID" id="30173868"/>
    <dbReference type="KEGG" id="kpin:30173868"/>
    <dbReference type="OrthoDB" id="10255449at2759"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
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                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
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                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Mohammad A.W."/>
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                <person name="Yurkov A.M."/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF48796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC72913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="730" mass="78622" checksum="C4A4E722D8B64C1D" modified="2016-11-02" version="1">MSAAISPAPISDNFINSKAQFSRRSTSYDMSNSNSSSFIRRGSSTLAVVPENYDHHPVKPPTKQISPPSAYNQQQPMQAQRKSTQRSVSDVTPSLNSSSAGSLREMDKALEMKMRRTSPEKGKSKELPRTASERRRRADWAIDLVETSQGAEIWSEDQRVILVLGETTPASLAPILYDPAFSETLLLVGSFEPLPSIEALLSPSHLMSSSPNQQIFPTVQPFTPSIESNDTDAHALTVLLAQAASLAQQFRSKPRGSISFPRPRAGSNASSSASNSPPSTPPMRKRVLSNFGSTSGSASNRSSIDSTMGTNDRQRSISMYDTSNDSTPKAKNRLTSFGRDSIFGGFRRGSDASDFSGSPANSSSGQSGSLFDAVINFIPDMKNYKPERALQDMLHQAVVITTGIMPSLTRQYGKSSNNFEMPISVLHVLPKIMPTPLPSVIESFLLSLLPTFQLRCPREIFGSVVTTPVWLSPFVETNSTMNNKGTTFTGEDVSGTQVLLFGGIRCPYQVLGSAEDFRPRAFLANWSDCISMPGLIAEARRPSSNPTTSSRPSASGRPSIGHDRHLSSPPSVPYNSTQARTPPRSRSPSPSKNLNLLPSGRSSPTSIPRSMSMPMPNTSSMKRSKLNVSHTPPMSSEVDLPQTSPTKEIPAIATTSNGQSPPTPDLDSSVNSSSCASSFALGETASGRGSEQGGEVSGENVKIVNHTELAGTGKNSVHTKKGLKSWFKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I009</accession>
    <name>A0A1B9I009_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_05654</name>
        <name evidence="11" type="ORF">I206_106798</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC72834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010092.1">
        <property type="nucleotide sequence ID" value="XM_019157374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I009"/>
    <dbReference type="STRING" id="1296096.A0A1B9I009"/>
    <dbReference type="GeneID" id="30174023"/>
    <dbReference type="KEGG" id="kpin:30174023"/>
    <dbReference type="OrthoDB" id="2563896at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051836">
        <property type="entry name" value="Kremen_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269">
        <property type="entry name" value="KREMEN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269:SF16">
        <property type="entry name" value="PROTEIN SLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628302" description="WSC domain-containing protein" evidence="8">
        <location>
            <begin position="20"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="9">
        <location>
            <begin position="569"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="9">
        <location>
            <begin position="687"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="9">
        <location>
            <begin position="791"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="127"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF48873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC72834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="892" mass="88177" checksum="173088A320094A2B" modified="2016-11-02" version="1">MLSTYALLPLVAFFSLTEAGPVNRRTPASTAATSTTTTRATGDLQTYNSGIGSIFAPAVTKSGNYWYSSGQQYNFLTEALSGSCYYQMNQCQLKANQQGNTPFAVSDCNGWQIQACLNSGSGSGSSSSSAASPSTSSSASSSASSSKGSSSASSSSSSSASSAAASSSAASSSASSSKASSASGASSSSASSASASSSASSAKASSSSSSSASSASASPTTAPSTTIADNFQTFNGAAGGVVAPAVTRTAFNTWVQSGNSYSDMYTALQQSCYAQASSCSSSSASFDHSVCWNTQVSACLSNASTYSSSYSTSVASANFAAATMARTVSGDLQTFTGALANIPAPAVTGTQYHWVEAGRSGEFYNLIDALRQSCYDQQDKAGAAGSAVNWAFELSTNNIYNVQINNCLTNANNVAANWSPNSSSASPAASVSSSASATSSASASKSASTSSSASSVASASAAATSAPVSSTIDAVAQSAIAYSSSVSASAYAASLASLASVASAASVASHESLASLASVASVASVASVASVASVASVASVASVASAAASSSAAAAAASAAALLPPSGWSVASTACIAEGSRGRALNGASLASSDMTYQKCATFCEGKGYNIFGIEYSQECYCGANLSNGASLSLPSNNCNMPCGGANGAICGGSNALTLFVKSSALSAGTWSSDLTTVNVALPIGWVAASSTCIQEASSGRALAGASYYDDNMTIGKCLAFCKAQGMQWGGIEYSRECYCGNDLVNGASLDKTGSCDMSCPGQLGTICGGPNLLSLYKDTSLLYSLTKVGDYSKQGCIQEVAGRALTGASLVATDMTLEKCTSFCSTKGFAFAGLEYASECYCGNSLVNGATLGAFSTQCNMPCAGNSAQNCGGPNGISLWSTLSGNALVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I0C3</accession>
    <name>A0A1B9I0C3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_04669</name>
        <name evidence="2" type="ORF">I206_105849</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF48982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC71890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010201.1">
        <property type="nucleotide sequence ID" value="XM_019156399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I0C3"/>
    <dbReference type="GeneID" id="30173038"/>
    <dbReference type="KEGG" id="kpin:30173038"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCF48982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC71890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="168" mass="18607" checksum="24C46ED816D532D8" modified="2016-11-02" version="1">MTAPRHKPRSTEDYTSVDAANLRLELSHIQTLGLEGHTLLTVESVDTAVSGKVHDPNQCSRRMSDNLKAWEEFIMIPTKNKDGEYHLTVYDPTRAFCPDAESYAALILTKESGREIERQRNSRAPYSVNVTVYGYPSVSISQRASAYADSYLGTSGMNTPTTTASRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I0L1</accession>
    <name>A0A1B9I0L1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VHS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_04773</name>
        <name evidence="4" type="ORF">I206_105950</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC71991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010305.1">
        <property type="nucleotide sequence ID" value="XM_019156503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I0L1"/>
    <dbReference type="STRING" id="1296096.A0A1B9I0L1"/>
    <dbReference type="GeneID" id="30173142"/>
    <dbReference type="KEGG" id="kpin:30173142"/>
    <dbReference type="OrthoDB" id="10068368at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14232">
        <property type="entry name" value="GAT_LSB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16980">
        <property type="entry name" value="VHS_Lsb5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044103">
        <property type="entry name" value="GAT_LSB5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045007">
        <property type="entry name" value="LSB5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789:SF1">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VHS" evidence="2">
        <location>
            <begin position="34"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="512"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF49086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC71991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="587" mass="66176" checksum="B2CE14437E8FB89E" modified="2016-11-02" version="1">MSNAGGYFKTAKALLSHLEEGKPHSSITDWVEVLSSDRYDELSLDGIPELVESINIQGYQGTTEGTRAIRKKLKYGNVHRQLRALVILRALTENAGKGFQLGWANQQLMDRLKEMANDSLLDPKVKKRLIFVFHAWSLHYKDEPRMQEVAKLYSKYGGAGPGVKKPTPMAPTKQSSVSSTSSQTTSANRGGFDDDLFSHDWAPSKGSRGPDTYTDLAAAKADADARKRERESRILIEQREAEVERRERELRRKQDMAALESRRQKEALEEAERRRQAKEDAKKRGKAPQPKRPPFDFQKEKPQVMVSIANAIQCANNLVNSCRHIDRSVESVLESPKVQDNLDKAKAARRPIIRYIQLVTDEEFVGTLLDANEKIVEAIQLYDRLSKPAVLDSDSDDDEAKETAAIAKRLAAQKLESQRTGEIDQLQSRQKKESARQALRRQQSVQKQPTRQAHPDLADLDFGSISQTKDKGRGLPQPMRPDSDDESYDGQRTLSDYSDYDYNSSDDDWRAQQQSRSRGPSRRQSIAAGGGRQASQRDYASLEDEFGTSLGQGKKGLLDPNDPFGDPFADDNDTPIQENRRMQWAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I0T5</accession>
    <name>A0A1B9I0T5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-hydroxyacyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I206_04837</name>
        <name evidence="17" type="ORF">I206_106014</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.35" evidence="4"/>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010368.1">
        <property type="nucleotide sequence ID" value="XM_019156566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I0T5"/>
    <dbReference type="STRING" id="1296096.A0A1B9I0T5"/>
    <dbReference type="GeneID" id="30173206"/>
    <dbReference type="KEGG" id="kpin:30173206"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000009">
        <property type="entry name" value="Fatty oxidation complex, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006180">
        <property type="entry name" value="3-OHacyl-CoA_DH_CS"/>
    </dbReference>
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        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
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        <property type="entry name" value="3HC_DH_C"/>
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    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43561:SF3">
        <property type="entry name" value="HYDROXYACYL-COENZYME A DEHYDROGENASE, MITOCHONDRIAL"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
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        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 12" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="15">
        <location>
            <begin position="46"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="232"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="51"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
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    <feature type="binding site" evidence="12">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
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        </ligand>
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        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
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        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
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    <feature type="binding site" evidence="12">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="11">
        <location>
            <position position="186"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF49149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="WWC72054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="337" mass="36807" checksum="AB99E3DA724202D0" modified="2016-11-02" version="1">MLSPTLRTTLNIMSTIRTQMNLAAANRLSTVHRHLSTTSQVNKIEKLTVFGAGLMGAGIAQVGAQSGLKVILSDVTDKALENGLNIISKSLSRVAKKKSPDDIEGFTSNILKNIETTTDAAKAVQDSDLVIEAIIESIKVKRDLFGFLDEKAKAECIFASNTSSLSVKEIAESCSNDRQARFAGLHFFNPVPAMKLVEIIKTPQTSTETFEALKEVTLRMNKSPVSCNDTPGFIVNRLLVPYLLEAIRMVERGDATPEDIDTAMELGAGYPMGPFKLLDFVGLDTTSYIAQGWREKAQSGEISKELVEPIGLLDKLVKEGKLGRKSGQGFYEYDNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I154</accession>
    <name>A0A1B9I154_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_04965</name>
        <name evidence="5" type="ORF">I206_106140</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="OCF49276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="WWC72180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_019156693.1"/>
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    <dbReference type="STRING" id="1296096.A0A1B9I154"/>
    <dbReference type="GeneID" id="30173334"/>
    <dbReference type="KEGG" id="kpin:30173334"/>
    <dbReference type="OrthoDB" id="47374at2759"/>
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        <property type="component" value="Chromosome 8"/>
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    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:mitotic sister chromatid cohesion"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
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        <property type="entry name" value="GNAT_dom"/>
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        <property type="entry name" value="N-term/lysine_N-AcTrnsfr"/>
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    <dbReference type="PANTHER" id="PTHR42919">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919:SF8">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="50"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF49276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC72180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="243" mass="26361" checksum="FF783BBA9EA83736" modified="2016-11-02" version="1">MAKTANTPTYSTAGTVSAPIDLSGLKGEYTTLNLQNGSKGKKVVKPNVKVTLTSLTINNSGTLRRIYSVVIPIIYSDKFYKEVRDPLLDDVNKLIYYADIPVGAICCKFDNLAKGSKEPPTLVILTLAILAPYRSLNLGTSLLLSSLKASINPITPPPPIPSDNKTNTRSSLTVVPPRVKVNRALAHVQVGNLDAKRFYERLGFKEIGIEENYYSKVEPHGAIIMVCEDITTAIGENQPNGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I1F1</accession>
    <name>A0A1B9I1F1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADPH-dependent FMN reductase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_05056</name>
        <name evidence="3" type="ORF">I206_106230</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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                <person name="Litvintseva A."/>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="Litvintseva A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010720.1">
        <property type="nucleotide sequence ID" value="XM_019155762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I232"/>
    <dbReference type="STRING" id="1296096.A0A1B9I232"/>
    <dbReference type="GeneID" id="30172391"/>
    <dbReference type="KEGG" id="kpin:30172391"/>
    <dbReference type="OrthoDB" id="2559962at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF579">
        <property type="entry name" value="3-BETA HYDROXYSTEROID DEHYDROGENASE_ISOMERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G02250)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioester reductase (TE)" evidence="3">
        <location>
            <begin position="72"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF49501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC70445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="362" mass="40521" checksum="EC0E4360A45766B5" modified="2016-11-02" version="1">MSATNTSRPVVAITGLNGYIAIHVALKFLREGYDVRGSVRSIKSIEQINSNPVWKEWIDKGRVQVLVVPNLEGDLTELLKGVEVIGHLAAPVDMTLTSWEAFRCPTINGVLSILKQATKFDSIKAISLMSSIAAAFNPVSNDQQIGKVYTEADYFPYDEEFCKTLDNSNPFASVLWYCAAKKYSEFAVKDWIVENKPSFSVATLCPPMTYGPLLHLTSPDQFNGLNGSQPGWLSLIKGKESNVPEPEATMYADPRDVAEAFYQAAIERKNERYLIASDSYTYQMFVNEFGKQRPDLDAYFPLGNPSAPTPEEQNFWIIDTSKSVKELGLKYHTLQETSKDTLEHYEQIGVFKVAPGSWIKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I236</accession>
    <name>A0A1B9I236_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Uracil permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_04138</name>
        <name evidence="8" type="ORF">I206_104285</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010835.1">
        <property type="nucleotide sequence ID" value="XM_019155877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I236"/>
    <dbReference type="GeneID" id="30172507"/>
    <dbReference type="KEGG" id="kpin:30172507"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF15">
        <property type="entry name" value="NICOTINAMIDE RIBOSIDE TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCF49616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC70335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="566" mass="62013" checksum="00D21129177B0ACA" modified="2016-11-02" version="1">MVWDKQTILLKLQVPQSEEEAEVWQNSKWLNRDNVPLPPSRRNWGMWSYAGFWITSGVNVSGWASGASLMSLGLTVSQAMIVNVLGGFLVAAVIVCTGQMGARWHVGFPMWNRMVWGLRASYFPLINRIILSFTWCATQGWLGAQCLKTLIGSIIPGIYTMKNTMPVSTGMTSADFLCFVLFTLITIPCLLIPPEKLRIPMITIASCSSITAIIMFIWSLARAGGGGPLLRSEGLELVGVEAAKGANLVWAIFHGLSASLGAICAGILSQSDYTRFARRPIDPLVSQVIIAPISGTIVCVIGLICASSAAKIYPEEPLLWTPYGLLTAIQLHENTKGARAAVFFASLVFTLAQLGINIPGNCLSGGIDLTSLLPKYINIRRGAYITLVMSIAMCPWALSSGATAFISVMSGYAVFLAPMTGLMVFDYFFVHKRQVKLSALYDATPNSVYWYWKGCNWRTIVAWIMGVWPTFPGFLHSVGAKVTISLPWSRIYYLCWPLGFFVSGIVYLILCKISPLSGIGEVDDEDIFGTHGPPNVPQVEGDEEKEQINEDSKDLVHEVAIVQVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I292</accession>
    <name>A0A1B9I292_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_04185</name>
        <name evidence="11" type="ORF">I206_104237</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
                <person name="Sun S."/>
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                <person name="Young S.K."/>
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                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
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                <person name="Berlin A.M."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
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                <person name="Gargeya S."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
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                <person name="Yurkov A.M."/>
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            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Abouelleil A."/>
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                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
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                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
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                <person name="Imamovic A."/>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
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                <person name="Hansen M."/>
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                <person name="Imamovic A."/>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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</entry>
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                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
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                <person name="Dewar J."/>
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                <person name="Griggs A."/>
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                <person name="Imamovic A."/>
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                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="Gargeya S."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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            <strain evidence="5">CBS 10737</strain>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
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                <person name="Young S.K."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Gargeya S."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
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                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
    <sequence length="107" mass="12598" checksum="05CD330D1F2DF9C5" modified="2016-11-02" version="1">MTNLESSNNQVYLEKLHYLLSRTSEGSTICPSQIPRLLNKEDSINYPNWRELMDSVRSLIWEQVKIGNVQVTQKGEIRKYEERNEIKGPIRVKKGINWTEDLLIHQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I5G1</accession>
    <name>A0A1B9I5G1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_02816</name>
        <name evidence="3" type="ORF">I206_102465</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF50760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011979.1">
        <property type="nucleotide sequence ID" value="XM_019154576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I5G1"/>
    <dbReference type="GeneID" id="30171185"/>
    <dbReference type="KEGG" id="kpin:30171185"/>
    <dbReference type="OrthoDB" id="2576412at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF50760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC68536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="126" mass="13879" checksum="73D8075E8AC355AA" modified="2016-11-02" version="1">MAPIVGTSKGIKRKAGGNGKKGKVFVEDKKDLLSLMSSITSSKDNIAEKKISKRKAILNEENQLITEGKKEKSKKTIEKEAALERAKTTLIEKQRLKKIKKSSSSAILDKNEPSIDIPKKKKVGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I638</accession>
    <name>A0A1B9I638_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">cystathionine gamma-synthase</fullName>
            <ecNumber evidence="7">2.5.1.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">O-succinylhomoserine (thiol)-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_03013</name>
        <name evidence="11" type="ORF">I206_102660</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of L-cystathionine from O-succinyl-L-homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2-oxobutanoate, succinate and ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>O-succinyl-L-homoserine + L-cysteine = L,L-cystathionine + succinate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20397"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57661"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="EC" id="2.5.1.48"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-cystathionine from O-succinyl-L-homoserine: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.48" evidence="7"/>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF50951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012170.1">
        <property type="nucleotide sequence ID" value="XM_019154767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I638"/>
    <dbReference type="STRING" id="1296096.A0A1B9I638"/>
    <dbReference type="GeneID" id="30171382"/>
    <dbReference type="KEGG" id="kpin:30171382"/>
    <dbReference type="OrthoDB" id="10047078at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003962">
        <property type="term" value="F:cystathionine gamma-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000094">
        <property type="entry name" value="Probable cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000063">
        <property type="entry name" value="Probable cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051750">
        <property type="entry name" value="Trans-sulfuration_enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699:SF1">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="180"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00051441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00058439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00060510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00066530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF50951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC68726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="658" mass="72170" checksum="08221DB31DF5C064" modified="2016-11-02" version="1">MPSTVFAAPPISMPSPIPLGASVPALTAHAISVSLPTWEDNIGYEEGEQRVVDRMETGYPRFFIHRSIQKLAALCLAKFGRPDELCILLPSPKVAGEGRDFLASQNPSIPARIVEFVICPSAVSIIDTSNTKALGGVDCIELQILLFHKSNWSFGKAFWQHSGDGICSRLAERALAFLGETPAGSTNRPPTPPTLERPPSKAPSTRNRHYSRRTNSVPPTPITPSTPSTPTLDKDDIPVEPVKEEALTPDLTTYLEERYGRNMPLFNAPLAKQALKRRIAGGLLPSDEGYGTVDDVARGAGSGSGKRAVKEDDVYLYPCGMSAIWHAFDIARTARRRKGEKEGKSVCYGFPYTDTLKILEKWGPGCHFLGAGGTADIPALEKLLQNPDKEAPILSLFCEFPSNPLLRSPDLVKIRQLADEYGFVIVVDETIGNFINVEVVEFADIVVSSLTKIFSGDANVMGGSLILNPNSPIFEDLKAAQTEIYEDNYYPEDAVYMERNSRDYRGRIKRVNDNAYDVTDYLFKRSLADRSTPLEGKVIKQVYYPRFETPETYKQAQRLPPTGKGGFGGLFSITFTTEAASKAFYNTIGCAKGPSLGTSFTLASPYTILAHYLELDWAASHGVERGLVRISVGQEDQAVLRNWFESAVQAAEDAGRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I6K0</accession>
    <name>A0A1B9I6K0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_03213</name>
        <name evidence="11" type="ORF">I206_102862</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF51147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012366.1">
        <property type="nucleotide sequence ID" value="XM_019154963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I6K0"/>
    <dbReference type="STRING" id="1296096.A0A1B9I6K0"/>
    <dbReference type="GeneID" id="30171582"/>
    <dbReference type="KEGG" id="kpin:30171582"/>
    <dbReference type="OrthoDB" id="1661054at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007255">
        <property type="entry name" value="COG8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04124">
        <property type="entry name" value="Dor1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="593"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="878"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="8"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="593"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="683"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="928"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1008"/>
            <end position="1018"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF51147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC68926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1018" mass="109991" checksum="5CDBD869B7490F1C" modified="2016-11-02" version="1">MDVEDRTYSSPVASISGQGNSVDSGHSFMTENDPPLSLIDLLQSSTDILDFSNPPADQYVDQLLSLSLHELLRQPQLISAETSTVESDLINLCFREYPTFISVHKCSSAVSSAFDDFSGSLGKLIDAIPSLEDECKAFSTSTGSIQNVRGKAALVQEHQDKLMDLLELPQLMETCVRNGYYQEAMELLNHCRSLASKYPFVPLIQDVNKEVEGILQLMLAQLLALLREPVKLPALVKTVSFLRRMDALDQNELGLIFISSRYHNYRTQLTLIDRDKADPVRYLRKYIDLFREHVYDIIAQFTAIFLEISPSEVAAIHITSFADQAVTDLVELVTAYIPRIASDSGSMSSILVQLGYCAMSFSRVGLDFAPLVSASFASTVISTFSQSLATASNDFGSILRNSAKAVLPPSQILVVAEHIAHIVSSPTSPPALPSIDTISHYPPLATLMNAYISAFNSLRLLAPLELHSQITSTLSSSLLASTNVLLQYVRQATTLSDEPPMSPVKTRPGHRRTPSTPRADLLRRNSEVLMTADARAAKRREARRVCVACADLWCRMVVPFLVDKLDDGVFADIPKPDPSKDLSGKLEELKSWVRDNEEGSEEKVRMNGNGDASQSLHSVLENDHKPPTTPPRRTIPLASAFDSPSHSSPKTPAIPNLATPTPKPASGQLTPHSNGIEAVFDSPRSSTSTTNGIAPLSSSDPADLQESGYDTVQPMNVQSELMDVGLTGEEAAVAVNVEHDINHHTQNSGSSALELNTDQKPALADAIDLKAERMADLPAERATSAIHAPYPLDTLDNITAESLNTVKSKDELPSTVAPDQAEPNFAPSSPIVVEIAPEPTTDAVDINKISLSSPSQALTPVIEPSKPMNSQIFEAREDTRSNDLPQGQPASAEAKTPHKSVDAVNQEALKAPISPAPPNGVDVSLEDQMQRESTEGNKLKIAESSGQPTDDTAENSHPAETPEDISAPDTPIELESHPASTNPSRPVSPDGEAEKQTAVTSGSSGGGAKKKKKKKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I759</accession>
    <name>A0A1B9I759_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Purple acid phosphatase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_02094</name>
        <name evidence="3" type="ORF">I206_104560</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012599.1">
        <property type="nucleotide sequence ID" value="XM_019153859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I759"/>
    <dbReference type="GeneID" id="30170463"/>
    <dbReference type="KEGG" id="kpin:30170463"/>
    <dbReference type="OrthoDB" id="2566935at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628385" description="Purple acid phosphatase N-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF51380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC70609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="15093" checksum="AE34ADC6E3182CDB" modified="2016-11-02" version="1">MLFLHSLAFLLLSLFVSAAPISSSPKRIPQAVAYEPVRFINHFGSSIQPDTSINLEWTGGSGKGFDVYYIPQWPQQKEYYPVELVSGSTSNHFTWHTPKADEFPKGTTFILGVNDAVTSLSSDWYDITGMMNFAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I7G5</accession>
    <name>A0A1B9I7G5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_02168</name>
        <name evidence="5" type="ORF">I206_104632</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012673.1">
        <property type="nucleotide sequence ID" value="XM_019153933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I7G5"/>
    <dbReference type="STRING" id="1296096.A0A1B9I7G5"/>
    <dbReference type="GeneID" id="30170537"/>
    <dbReference type="KEGG" id="kpin:30170537"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF16">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF51454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC70681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="311" mass="34075" checksum="BD0699FF9751798C" modified="2016-11-02" version="1">MSGQDDKPKVVTAYKEMTEIKKQEQNLPGKDTAMDPLAEFTKLEKWNDNGEPYLEEYRGNGKLKGKTAIITGGDSGIGRAAAQQFAREGADVTIVYLPQEEEDAQRTKKAIEQDGQRCLTLALDLMDENNVKKIIEEHLKAYGKLDILVNNASKQIMCEDLADIKMENVESTFRSNILGMFALTKYALPHLKRGASIINSSSVTAFKGSQAMVDYSSTKGAIVTFTRSLAMQLAPKGIRVNAVCPGPVYTPLQPASRPAESMEDFQIGSLPLHGRANQPAEMGPAYVFLASADSNAMSGQMMHLNNLQYMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I7K1</accession>
    <name>A0A1B9I7K1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7102 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_02212</name>
        <name evidence="4" type="ORF">I206_104674</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012717.1">
        <property type="nucleotide sequence ID" value="XM_019153977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I7K1"/>
    <dbReference type="STRING" id="1296096.A0A1B9I7K1"/>
    <dbReference type="GeneID" id="30170581"/>
    <dbReference type="KEGG" id="kpin:30170581"/>
    <dbReference type="OrthoDB" id="2422840at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055528">
        <property type="entry name" value="DUF7102"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23394">
        <property type="entry name" value="DUF7102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7102" evidence="2">
        <location>
            <begin position="667"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF51498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC70723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="888" mass="99953" checksum="11C03EF868BAD3C1" modified="2016-11-02" version="1">MDIPSPQHRRPINGSSSRSTEIPCVEDDHRTVTKRETIESLERLQSVPLEEEDNSLKSFRQSLEEASKIYTPEKVISKPQTVPKSVIDFCNAAQDRRKQAMIESPAEKILEKPIENPCHHFIQPMETMLTAKAIKKSHNLSQGKKVVPSKLSQLNGRGKFAIFEKLDIPPVPLKEMDTFKILKWQTTCTNDERQGILKMNSERTAQLEPYIEAAKGDTERLPILEAQYERAANLFKNMSQSVDPPMLPAWEYRSHCTAAIKPLHPETTVAPEEAAITVAEASDQIVEDIRATGDSLCSPSISKSRRREPDDSDEVLIPTPISSPTTGQLRTRWSIENDRISSSPQTVNLPQLMKINRDQEWDESTESVFKEYLNPAAFCSSIHDMQQPQVNDEAARSLAWSPIPAGHLPVINPFARSNHGSQSGPMSSPIAVSKVQPIRRRAVPAIKGEIEPPIVGHPPHVSEQPPSRRLNNTGAHLHDRPPLSSAETDVPITSKLPSSVPNKRPLDATQEARATRPRSAYTTSQSLQDLLIKPAAQIRDTGSATPKLKVVTANETKAIKGEKVSRDSRPFDLFSLEGLFSLAERDDLNKTTEELYGLRPRSQEEYRRQIDWTANSLVRNPVWYEDACNLSIPYDSKLPPILIAISVLQKLPLFRALKKEGFTTVEKEKKMHSADMVISPATAIILQDLKSLPQHSMDLLQELKVTACKFERTIIIIECINYTACEKDPNAKNKSNPLSEDAMKAITQFKYFMPRALGSADGSTGEVEVIFSYNGAVEVARIIRWLIEDDRKRLKDIDSEGHQAVYEDRQWLTNEPNEEELELLTAQFGLNIFCAWYALNYSPSIHQLIEGMSDSERFKAFSGIFGTNVLDRFNEAIKQWKATSRQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I7S0</accession>
    <name>A0A1B9I7S0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylglycerol/phosphatidylinositol transfer protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_02293</name>
        <name evidence="11" type="ORF">I206_104755</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NPC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012797.1">
        <property type="nucleotide sequence ID" value="XM_019154057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I7S0"/>
    <dbReference type="STRING" id="1296096.A0A1B9I7S0"/>
    <dbReference type="GeneID" id="30170662"/>
    <dbReference type="KEGG" id="kpin:30170662"/>
    <dbReference type="OrthoDB" id="6409159at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00917">
        <property type="entry name" value="PG-PI_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.220.10:FF:000002">
        <property type="entry name" value="Phosphatidylglycerol/phosphatidylinositol transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.220.10:FF:000004">
        <property type="entry name" value="Related to phosphatidylglycerol/phosphatidylinositol transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.220.10">
        <property type="entry name" value="Ganglioside GM2 activator"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036846">
        <property type="entry name" value="GM2-AP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033917">
        <property type="entry name" value="ML_PG-PI_TP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039670">
        <property type="entry name" value="NPC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306">
        <property type="entry name" value="NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306:SF0">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROL_PHOSPHATIDYLINOSITOL TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628403" description="Phosphatidylglycerol/phosphatidylinositol transfer protein" evidence="8">
        <location>
            <begin position="19"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="9">
        <location>
            <begin position="54"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF51578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC70803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="186" mass="19857" checksum="5E8BB40C2354FA61" modified="2016-11-02" version="1">MRLISLALVPLLATAASANLAADALGWAGELVSGGGKVSTAKDGDVRTMDSWSYVDCGLATDAVQIKSIHVTPDPPVPGKNLTVEVEADVIQPIKEGAYADVTVKLGLIKLLQKQFDVCEEARDANATVQCPVAPGPYKVKQTVELPKEIPKAKFSVQVRGYTDEEEDMVCLDLFVDFMRRPGGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I839</accession>
    <name>A0A1B9I839_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_02388</name>
        <name evidence="11" type="ORF">I206_104848</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012892.1">
        <property type="nucleotide sequence ID" value="XM_019154152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I839"/>
    <dbReference type="STRING" id="1296096.A0A1B9I839"/>
    <dbReference type="GeneID" id="30170757"/>
    <dbReference type="KEGG" id="kpin:30170757"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17919">
        <property type="entry name" value="DEXHc_Snf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056616">
        <property type="entry name" value="Chromo_MIT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF17">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="Chromo_MIT1"/>
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        <property type="entry name" value="SNF2-rel_dom"/>
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        <location>
            <begin position="990"/>
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            <begin position="1"/>
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        </location>
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            <begin position="15"/>
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        </location>
    </feature>
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        </location>
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        </location>
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    <evidence type="ECO:0000256" key="1">
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF51673.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC70896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1255" mass="141489" checksum="377CBC5F555DF26E" modified="2016-11-02" version="1">MVKSHLTEKERQSRQETASSDPLAFSSSPERPKRASKVNYNEDEQIDEDDEEEEEEEEEEEEDVIPIAAPKDVSNSTKVDSNLRRSPRNSFLPITKSAPNSSSNSKVQTIVDDTPIKRKQGRPRKVPIASISTVSSYVDSRESSITAFFDKLNGNRATRSRGNGNSMARHGKDDEPIEIDSSSESENRAVTNQSSSRSSKFVDNRQNAVVEIPLMPLEDVYGYPHLRKDTANPTKSSRNKLPGIASESSYQPSEASFSRFQSNGKRRRGSSPSYSEENDDGDVSDEGSESYSGSESDKVALRRSGRAGVKGNGIRKGEEDNEIAFRTRGKRPARNSPQTISSSSASDFDSSPSDGHRNKGKSKMVLSTKTKVKALSSEDEFNIISDTSDLLDSEESDLSEFAKPKKNKQKGKGRGSTKFTITEDQLYTHRPFCELCLREPADEMLFRARNRQKRKKRNDDVITDDELADKLGGWLECEKCVVSSHWGCLAAPIKKDVLSVLREREGTPAEGEKPRRSVEVDESATFVCAKCSLNPNCFVCHSDKIKKADKEPMDPQHDDSKLNEMEVDQNEPVAESQKAKEEVDAEEEDEVPKFRCFRCRQCVHYKHLSIPKSLGEDPPLPEVAYHYQNRTSDGDAWICHQCRKWIWTVDLVVAWRPSPPGAVEPELAADEAANWRNPLPREYLVKWNTRGFRHVTWAPHAWLQVVALLKLKHFLEKGPNLDLITDETLAAKGDEMAQPTIANLTAEDDQVASKRGHGAEHGSNQDGKKEWIGLGPGPEVDAESSLPIEWSTIDRVLDVMLLPPTSTKSAPSGKKRGKRVMSTSLSPSASVNGSTAPPNNLQVNGNATLSPADKMRQEYGLIDGEEPPEDMQVEIEEWEQLTGRSLDEDDVDEVAGLVTWCFVKWDDLQYDQSTWDTPPPTDSPLYSAFKHALKRYLRARKVDVPVLTAKQCKIRDEGAEQAYVPPSNQPDCVVGGSLMPFQMEGFQWLLYKHFRRESCILADDMGLGKTIQIASVLGYLGSNQYKIYPCLVVVPNSTITNWVREFEKWVPHMRVVPYYGEAASRKVISRYELYHKGHQGRAEGLKAHVVLTTYDMITGHEFNRVFGKIPRWEVLCIDEGQRLKSDDSLIFRKLRTLNSVHRILLTGTPLNNNLRELFNLLNFLDPTKFQELGDLEKRFENLNETLISELHEMIKPYILRRIKADVLKLPPKIEIIVPISLTPLQKQVYKGVFEKNSELIQAILRARKKRIRMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I842</accession>
    <name>A0A1B9I842_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_02374</name>
        <name evidence="3" type="ORF">I206_104834</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012878.1">
        <property type="nucleotide sequence ID" value="XM_019154138.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="30170743"/>
    <dbReference type="KEGG" id="kpin:30170743"/>
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        <property type="component" value="Chromosome 6"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <end position="132"/>
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            <begin position="403"/>
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        <location>
            <begin position="436"/>
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        </location>
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        <location>
            <begin position="450"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF51659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC70882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="557" mass="60423" checksum="F27C85B756C5C97C" modified="2016-11-02" version="1">MAQTISIPSSHLSNFYCPSSPDPTPLRLLAFSVAEAALQPDPNSPSFSMIMGKLPTPLEMDVWAQPSVRAPWATNTVSWHQRANGNAAPQAQVQNQNRKPLWDVVQRAKERRVQERCSPASTESTLPQSPPISPSSYNFVLPPNSPLAASVAAGTSPSKNAAMVPRNEYFPLFTQSAQPSPIESTFSGLDQSRPPPEFVPRLSASDFSAKARQTSSVAAKHGRTKSDFGSPASESKEITPEEKARAKSKLPSVPSPSRLPSLAQIQARVSTERQRCSSVGSPTKSVPRIRTVLRSDSSESFEVIKTPTDETPRREARIVLANILNRRPATPPSPPLTTAKHAEPRLAPFLRERTSGRLSGGKARPMSMPPMSLGELPSFEAICKANSGNKPSLKVTPPKERSSSFASTDSAGNVPSPTKGSFPWAMRSGMVTPTESRFSPFSLSTPPSLNHSTKSSPRKSFTSPASPTESVRSTFSSPSLGVPTITCTPAPQTIFKNGVEQNSDEEDVVLFEGDSFDVESIDSESEIDSVVEEDFKEEREKRAEAMKKRLMLRRTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I8D3</accession>
    <name>A0A1B9I8D3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_02534</name>
        <name evidence="4" type="ORF">I206_104995</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
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                <person name="Heitman J."/>
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                <person name="Sun S."/>
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                <person name="Litvintseva A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="Mohammad A.W."/>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="David-Palma M."/>
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                <person name="Bowers K."/>
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                <person name="Mohammad A.W."/>
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                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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        <property type="nucleotide sequence ID" value="XM_019154346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I8I6"/>
    <dbReference type="GeneID" id="30170952"/>
    <dbReference type="KEGG" id="kpin:30170952"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF51867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC71090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="133" mass="15039" checksum="1F63B2E4EB294C40" modified="2016-11-02" version="1">MSLPSALQPNNLSDREDASIMTNLSISRTAYSGISENLHETIDKPGIPPDIPPFGDQEERYDWITSILRVVAHGITRQEEDSLHAHKSSGEMEDEKNGPGSQELDTSKSALAIETWNSSRFRRNRNRRRRSHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I8R1</accession>
    <name>A0A1B9I8R1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_02601</name>
        <name evidence="4" type="ORF">I206_105061</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC71108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019154364.1"/>
    </dbReference>
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        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF51885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC71108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="143" mass="15705" checksum="75E5B7B8FA136772" modified="2016-11-02" version="1">MSDQIPSSSSSSSNAGPSKPSMISSTFTIPLKKSAEKVYTGPSPDQLSAPRTRSQAEKYFARVANENVLPTRANKLLGVGGWVLGGFACFYMALFADFGEREHVFSPVRRQYASLKQSFFTLSPSERQMMGINDVRENEARPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I8R3</accession>
    <name>A0A1B9I8R3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_02620</name>
        <name evidence="11" type="ORF">I206_105080</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
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        <property type="protein sequence ID" value="OCF51904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC71127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013123.1">
        <property type="nucleotide sequence ID" value="XM_019154383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I8R3"/>
    <dbReference type="STRING" id="1296096.A0A1B9I8R3"/>
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    <dbReference type="KEGG" id="kpin:30170989"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
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    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000187">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="148"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="510"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="590"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="683"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="235"/>
            <end position="242"/>
        </location>
        <ligand>
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        </ligand>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF51904.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC71127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="852" mass="93578" checksum="C5DBB31F1C43E584" modified="2016-11-02" version="1">MDAHARALMPPPHATPKPTSRFAPKTPSHLKSPPLTTSHNGNTPHYPEPISHVLSPKEGGSTRLKIKSATTPEAKSRVLVKPLGARAQIQRNNDLLATPSVRLVNRSITPNYEPTLADEGWMSADTHSQPVTMMNFEEYEDEMAETEAVLVSVRVRPPNPVEIRSDAGCVWTMPEHDQHLLKLAKGTEGMRGDRDWIFDRILPPESDNSRVYGTSARRHVKSAMEGYNAVIFAYGQTASGKTHTLSGSSIEPGIIPLSITDLFAQIRSTPDREFLLRASYLELYNETIIDLLSPVHGAELHLSEGKKGVVINGLTECAVRTEGDVKKLLRSGEDRRKVGATDWNARSSRSHCVFRITIESRARNSAIEEAPIGARTPGGRLKAAGEKMTRISTLSIIDLAGSERHTSSKERNAEGKHINQSLLTLKLVISKLADLASKRNVTHVPFRDSKLTRLLQNSLSGDALISVICTVSPSSLNLAESISTLAFAQGLKRVVLKAQKKEVVDPQALIQQYQNEIAELRAQLREKETGGSSKNEREKNQAMETRLNELKSMILTSVSVNSPNAEDGSNLVPPSPAKMKYPKLEYDRPSAELLEELHAEQLNRAELEDEVARLKAELATRPIEPNKEIVSLRNEVAELRLIADDYERHLLEPSRKVRADVEKDFGEKLKTLENQLDSKKIWANRLDENVRFITQENKALEMRCLEAESKVTQIIEFINLALSPSSSSSSSSCEQGLLPINEDEIESISSNSLPTLIVSDDFSPSLNDNYSGGLGGGGGKSTLTLSASKMRATFSQMDLANFNDKFGSLSIKGKKMKGLGINGVGGGGGWNGKMLREESSFALAEVAGDDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I8W2</accession>
    <name>A0A1B9I8W2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein-vacuolar targeting-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_01302</name>
        <name evidence="8" type="ORF">I206_103697</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0220 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC69754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019153076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I8W2"/>
    <dbReference type="STRING" id="1296096.A0A1B9I8W2"/>
    <dbReference type="GeneID" id="30169671"/>
    <dbReference type="KEGG" id="kpin:30169671"/>
    <dbReference type="OrthoDB" id="268928at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007919">
        <property type="entry name" value="UPF0220"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13180">
        <property type="entry name" value="SMALL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UPF0220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="92"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="144"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCF52018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC69754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="20294" checksum="287DCB4C9C202BEE" modified="2016-11-02" version="1">MSIPHATYDPRRVFRFSLPRFEVGPKVRSGGTYLSGGLFALSYFFLFDAATISSHAKPPPDAPYDVVPVHMSFVDWIPAICSTLGFLITSLLDKSHLSAAFSGDSWGGDGPAAVRARVVLFIGVALMAGGLAGSLTVLILKYIITEYTEYLYYGIMNVAMNGGMMISAIVLWVSQSGSDEYEYQLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I9P8</accession>
    <name>A0A1B9I9P8_9TREE</name>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_01509</name>
        <name evidence="3" type="ORF">I206_103487</name>
    </gene>
    <organism evidence="2">
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        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013442.1">
        <property type="nucleotide sequence ID" value="XM_019153281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I9P8"/>
    <dbReference type="STRING" id="1296096.A0A1B9I9P8"/>
    <dbReference type="GeneID" id="30169878"/>
    <dbReference type="KEGG" id="kpin:30169878"/>
    <dbReference type="OrthoDB" id="2113294at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF52223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC69545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="586" mass="67330" checksum="BAFF4B5440C1E417" modified="2016-11-02" version="1">MVSLLWTPSSPTTTPKLISRTFSQKRNLCFLVISLFILSFLVLGLHPNVQQNSIEQYDRLKEWSNDKAQNLAEGLSDDTVLGGTLKGWLDHSEKVEEKECKGWNHVLGEENDPPNCLKARQYRQTMRALEREEKAEHPHWYFTLQHNLETLRNISSCFLPVTDPDWRLCHEKPLILSGWWYTAEVITGATTGEVIWQSSIVKQLKMLGYSFIAVGPYLNWVEVAEMMPDVYHLIWNSDVDTVTCITDPRCIAKEHYVPPEDAEDLSIDVPDEERGVIPIWALAIVDYWGARPREMSNNAYWWGLTEDGPWSYHPLGQEWIATPWPLPGGHFHLPYSVEDYCLKMPIKPHEDRKNAALILAKRSSYFHYPQVSPPQFWTNLSQVPDFDLLSTVEEEEGKPIPDGLVTMGKQSKEDYTALVGSVKALVGMGAPPISPSIYISLCQATPVVIPYFQQDYRMDGWWLYSSWSQHGPAIALGEPYVYKYYSQNYTDLEDAIRRAMSTSIERYIPENMKLPYTLSQLSKYLSRDLKLMFKDVIDNNGGKIPKLKKGTRERCYKLNRCKEPLKIGRIPNIPSKFSSKAKAERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IA27</accession>
    <name>A0A1B9IA27_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sterol 24-C-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_01592</name>
        <name evidence="6" type="ORF">I206_103404</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013523.1">
        <property type="nucleotide sequence ID" value="XM_019153362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IA27"/>
    <dbReference type="STRING" id="1296096.A0A1B9IA27"/>
    <dbReference type="GeneID" id="30169961"/>
    <dbReference type="KEGG" id="kpin:30169961"/>
    <dbReference type="OrthoDB" id="4310724at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003838">
        <property type="term" value="F:sterol 24-C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000232">
        <property type="entry name" value="Sterol 24-C-methyltransferase erg6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030384">
        <property type="entry name" value="MeTrfase_SMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013705">
        <property type="entry name" value="Sterol_MeTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF1">
        <property type="entry name" value="HYPOTHETICAL LOC100005854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08498">
        <property type="entry name" value="Sterol_MT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51685">
        <property type="entry name" value="SAM_MT_ERG6_SMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase Erg6/SMT-type" evidence="4">
        <location>
            <begin position="44"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF52304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC69464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="343" mass="38468" checksum="A18711422F280F1E" modified="2016-11-02" version="1">MPADARSADRVSNYNKFWEQKSANDNESHRANRLDQYTEVVNGYYDGATELYEYGWAESFHFCRFYKGEGFLQALARHEHYLASMMHLKPGMRVLDVGCGIGGPAREISRFSDATIVGLNNNDFQIGRATNKTKKAGLSDKVSFVKGDFMKLSEQFGENSFDAVYAIEATCHAPNFEGIYGEIFKVLKPGGVFGVYEWCMTDEWDPSNPKHKEIAHGIEVGDGIPEMRNLTAARNALKTVGFEIEHEEDLADRGDVVPWYYPLEGDIWKAQTVWDMFTCWRTSKMGIFVTQNAVWALEKVGFVPKGTHSVGESLVVAANALVAGGRTKLFTPMALWISRKPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IAB9</accession>
    <name>A0A1B9IAB9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TPR repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_01836</name>
        <name evidence="6" type="ORF">I206_103159</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013764.1">
        <property type="nucleotide sequence ID" value="XM_019153603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IAB9"/>
    <dbReference type="STRING" id="1296096.A0A1B9IAB9"/>
    <dbReference type="GeneID" id="30170205"/>
    <dbReference type="KEGG" id="kpin:30170205"/>
    <dbReference type="OrthoDB" id="1936594at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044244">
        <property type="entry name" value="TTC27/Emw1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="563"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="597"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="306"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="268"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF52545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC69222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="904" mass="102363" checksum="D3883A473E4B2FE1" modified="2016-11-02" version="1">MTSLEWSVFQGEAPSSQAGPSRTQELASQLVEADFKAILTSNEARTILSDADLLEGLIISSSAPSKSEESPLLRLIVAVALLHSFVQANWTGPNLSFTPLDILPSTTANDDEINAAALPLLTLQGEPAYHLASQPALLLLSRRLFLSLPNSLKTLPTWLLRLHLVHLSLLDEAVPLPSESLDSIQSLLEDPIVIEDQDLKAKIELEIGLYHHALGQDKLANQSFLAAARTSELEFELTGALGKRTKYQIALLSQLVLLAESRTREGEVEINHTEQNDDQVKAEISTSSNLPESIALNDDTLLEETEFTKVSSSSSSNNSTSKLSHLDPSNQPPLHPLDQALLLSLCLSQHNNSPSSGLTANQMMPFLSRVIAHPRNWSIHTTGLLLRSRLESTRSRTVERSTLQLQALIEQMPTSDSSPKERLKYFHQLPLPSKWDMERELAKRFLSIGVTRSALEIFDRLEMWEDSVSCLQRLDREEEAIKLVKDLIEGKKIESDTLTTLAKENLSENRRNKLTEGRKSKLYCLLGDLSLSSEESVKDPVGAKKLAIEMYEKAWEISNKTSSRSMRSLGALYVGGQDYEKAIECFKSALEINPLYARVWFTLGVCYSRLERWNEAKDAYRRQVGVEEDDAEGWNNLAAVYLRLGEENKKDSEDVKSATFENKHLAWRALRQGLRFAYGNWRMWQNYMIVSIDVGELSEAARAMTRIVEELSNTPNLLESSIDFDVLDKLVDSVTRDDYSLIKQGKIIPKTSNEGFGLLPLVERLFNETILPKISNQSRIWKSHARLERWKENWIESLNDYLKSYRCSIVFNEKVERDLEIWLEALNEIEILIATLYQLGPKAKIQSENENQLNLNGEKIKINDWKFQAKGIVRTFMGRTRESFENEKDWQRLQDLLDDLKKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IAJ5</accession>
    <name>A0A1B9IAJ5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD40 repeat-containing protein SMU1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_01777</name>
        <name evidence="8" type="ORF">I206_103218</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013706.1">
        <property type="nucleotide sequence ID" value="XM_019153545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IAJ5"/>
    <dbReference type="STRING" id="1296096.A0A1B9IAJ5"/>
    <dbReference type="GeneID" id="30170146"/>
    <dbReference type="KEGG" id="kpin:30170146"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045184">
        <property type="entry name" value="SMU1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="318"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="360"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="403"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="445"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="527"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="546"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCF52487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC69280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="620" mass="68958" checksum="F4E8124F4B0A6ECA" modified="2016-11-02" version="1">MSITTPNQAGPSNLNDNLGETLHPHSKSDTALTPRQKEKSPLRNVDIDEIILDEIEFDSEIDLLIGQYLESRGIPSISNIWNESVLGINTSEERKEWIEDVERCILDGDYSSIEILISKPGLLKTQTQKSFLYLCWRQQFLEHVENRESQKGFNLLSKRLKPLEHYQPVPYDFYSLSYLTSASTVHDAPTFRDWAGVGPERERLVGMWRELMGSEKGVGQERPFVPPNRLKTLLKQAAAWQISQVESASGRSLKTPSLLSDYRPLQLLEKLYYLIKGHTANVKCVDLVGPRGDIGVSGASDSTLRIFSTDDYSTKHILQGHTSRIWSCASTSSGLAIASGSGDGKIRVWDVSSGACNTVLYIDGGDVYDVKWRPNKENQIVSASYDRILRFWDVETSKQVRTFSGHSQSTLTVAFDYTGNMIASGSKDKHIRLWDAVGGTCIKNITGCLGEITSVEFDQEGRYLLAGCKDNSNRLWDLRMQRNIYRYTGHQNTSKNLIRCSFAHNASLIIGGSEDGCIYLWEREGSSTVSDNSAPDIKKSLPSEASIKNTTSDGNSTPSYYPPRDKAASATNAPNKAIIETIKPLKVLEGHYEGAVFDVVWKNGKLISAGEDGCVGVWSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IAS8</accession>
    <name>A0A1B9IAS8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome maturation protein SDO1/SBDS N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_01962</name>
        <name evidence="3" type="ORF">I206_103033</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013888.1">
        <property type="nucleotide sequence ID" value="XM_019153727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IAS8"/>
    <dbReference type="STRING" id="1296096.A0A1B9IAS8"/>
    <dbReference type="GeneID" id="30170331"/>
    <dbReference type="KEGG" id="kpin:30170331"/>
    <dbReference type="OrthoDB" id="2567806at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="1">
        <location>
            <begin position="12"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF52669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC69097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="126" mass="13781" checksum="FD904807CAE7B8C9" modified="2016-11-02" version="1">MATTAVIWSPENSQEEFLVFVDDVAEYERWKGGATDIALSRFVGTFSIMKTTNSVGHTGQLGEVSKQEIQNVFFGGDKNKHAEEAIEIILKEGKSQKADYSHSYKLTLNPGRGAGSVKGQGNQQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IC29</accession>
    <name>A0A1B9IC29_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UDP-galactose transporter homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_00314</name>
        <name evidence="12" type="ORF">I206_101012</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014232.1">
        <property type="nucleotide sequence ID" value="XM_019152094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IC29"/>
    <dbReference type="STRING" id="1296096.A0A1B9IC29"/>
    <dbReference type="GeneID" id="30168683"/>
    <dbReference type="KEGG" id="kpin:30168683"/>
    <dbReference type="OrthoDB" id="1601at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005459">
        <property type="term" value="F:UDP-galactose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005460">
        <property type="term" value="F:UDP-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCF53013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC67105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="414" mass="45600" checksum="18C50E3D997A60FC" modified="2016-11-02" version="1">MGVVRLGVCVSGVYAAFLLWAIAQERLSAPFPSTSFRPHTSPEHHSKGDKFPSPLFLNYAQAVASSLSALCYLLFNAWKNGNLHKGLREIIGYNQLFSIGKVKTIKGEEIEPNGKEKLINGNGSSVNHQKSVAKPWKKSLPALLLQVSLFQGLAGPIGFLALRHISYPTMVLGKSCKLIPVLLLNVLLYRRKFSPHKYLVVILVTIGISLFMLLAESGKKKKAGNDSAWGLWLLGINLFIDGLTNSTQDQIFSTCRSFSGQQMMFFMSFFTQLLLLPALILPIPSNPLSFISHLPSPISSTISSTPIIFAKPEILNSISFIITHPDCLLPILAYALLGGLGQLFIFETIQHFGSLTLVMVTVTRKLFTMLLSVVVFEHTLTKGQWIGVGVVFGGIGVEAAMKRREMIQRTKKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IC47</accession>
    <name>A0A1B9IC47_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_00334</name>
        <name evidence="5" type="ORF">I206_100992</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894007">
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IC85</accession>
    <name>A0A1B9IC85_9TREE</name>
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        <recommendedName>
            <fullName evidence="8">UBA/TS-N domain-containing protein</fullName>
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        <name evidence="5" type="ORF">I206_00576</name>
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        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="6">CBS 10737</strain>
        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1422" mass="150131" checksum="023FCFF253559BE0" modified="2016-11-02" version="1">MTATYTPQEKQYYDQLFAIIDKDNTGILPGQDAYPFLTSSNLPTTTLGEVWALADPENNGFLTKDGWYRAARTIGWIQKGGASTVDETLSNKSGPLPTFDKGPPPPAVQPQPTGQRPQPPLSAHNTGTPVLPPLTPADRAKFTRLFAGAGPSNGLVSGDKARDMFLKSNLNYDKLGQIWNLADTQERGSLDLTDFVIGMYLIQSCMTNPNLTLPPTLPNGVYETASGGRAPPPKAPASPISRQHTGGAVPSPVRPQYTGGMIQPQRTGQSATGTGVSTPPRTSNTQKSFASPPTSSSFSTIPSTSSFGGPQRQMSGFTPTAQPWDVTPQAKATSDQFFTQLDSQNKGVIEGDVAVPFMLQSQLDENTLASVWDLADIRKEGKLTRDEFAVAMHLINSKLAGQDVPSSLPNTLVPPSLRDAYGNGAQEVLSSQRPSSATKDLFDVFGDDQPTPTPQVSSPQSQQQAPAQPFSAAAFLPQPPAPPSRKSTAPSSGQRGLSPAPTGQQQIVGGFGMAPFAPAARGGDLLGDDSAEDKPSSVPDHSAEFGNKQNQLANTTRNLSELEKSHAELDETAKSSAALLQELDEKLSSARSRHETETKAVTDLRIKVGEQKERHRKLESEVISAESDLSAMRSEKDELEQALLRDKEEIRGLQKMMKEVEEEKTGMKFVLEKLRKEARQQKGMLSIAKKQLSTAEGSRDSVQKEIKDTEQEIEDDKAELERGPPAASSPQHIASASPPAFFSPSMAAGVPLPPTPKALSPAPTGASTRSNNPFERLAGARSMAPPQQPSQSASPPTEVEQPTSPTFGTGALAGLTAAVGAAAGVAIAGAETLYDSAKEAVTGESSETKTQDDKDKEIDPFGAPTSFDEQKTPVPQGQGEDSDPFGVPPAAADSDPFGATTTPKPADQAGFDDFDNNFGDSFTALPASEPTIPTEDLNLAPASEHAGEALPASGNKDFDSAFADFDQAPPALDENQLALPDDGEAVSEELSEGLPSGIPKSAIPNELTARPEAERTFSTQAVAGESRPATPAPEALSSGLAGSPASVKAPLPPSGLAQEVIPVTTAEAESSDEEEGPEDLEAPKRGYSGGDNTEKRGEFDDFESSFPSNTNLATQEEPATTSPPVAPVAALAPPILSVEEPTPTKTRRHAPPPPSHKSTPPPAIASTASTVGGYSGGEEFDPFGAPVFSTTNTTATESQAPKTAAFDEDDFDFSDSPPATVDQSHQAPSAQGDISGGHQNFDDDFANFDDEFENVTPNNQNNGSDSTQSYEMVSPQIPQAHGQTQGQGETQRFDEWGFGGQPQQHNELASGQAQAQAAPKGFSFDDAFGGDFEPSGSRNVTEDHAFSPPPGPPPAQTQTRTQPEDQLQPPPMPQRRPSGAQPDDIEDVKKLCAMGFTRGLVVEALAANGYDFQKALNVLLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9ICG0</accession>
    <name>A0A1B9ICG0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_00371</name>
        <name evidence="7" type="ORF">I206_100955</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014289.1">
        <property type="nucleotide sequence ID" value="XM_019152151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9ICG0"/>
    <dbReference type="STRING" id="1296096.A0A1B9ICG0"/>
    <dbReference type="GeneID" id="30168740"/>
    <dbReference type="KEGG" id="kpin:30168740"/>
    <dbReference type="OrthoDB" id="420076at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004741">
        <property type="term" value="F:[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF792">
        <property type="entry name" value="GM14286P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCF53070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC67048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="372" mass="41302" checksum="5148C0596F08665C" modified="2016-11-02" version="1">MFSVFDGHGGCYAADLLGKTLHGVLAHNAGKMLEEGYKVGKDWENQMINGNMEHGLELGDDLRPALAAGQNPQSFAEMLSMSFMAVDANLLKTTQSLTFDPQFSYNHLLPPNNPSLLALANLFDMGSCAITAVIDVENDKLFVANVGDTRAVAGCWDPAKSKWRCDILTEDATCENEKEVERIRSEHPEDERFTAVFNQGFGDTNRVHGGLQISRAFGDDAYKLNHEEFKGDIHPVSGEELKFVILATDGLWDRMTSEEASYLLASHFTHEIQQDVSKVDVMAYCPHTLPAMDNEHPYPKEELNVHGKWVYEDANAATHLIRNAIGGEDRELRRQLMSMKRPGARSVRDDTTAIVIWFDDPQNMVNKGGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9ICQ1</accession>
    <name>A0A1B9ICQ1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I206_00728</name>
        <name evidence="16" type="ORF">I206_100597</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bud neck</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014644.1">
        <property type="nucleotide sequence ID" value="XM_019152506.1"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9ICT5</accession>
    <name>A0A1B9ICT5_9TREE</name>
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            <fullName evidence="2">BAG domain-containing protein</fullName>
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        <name evidence="3" type="ORF">I206_00515</name>
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        <name type="scientific">Kwoniella pini CBS 10737</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
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            <taxon>Cryptococcaceae</taxon>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
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                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
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                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </evidence>
    <sequence length="768" mass="84958" checksum="334028A91F435D64" modified="2016-11-02" version="1">MFPHSYHSYTHGYPTQRRGFATQPSPAYHHPASYLHQSSPPTPLFDSYEQSHDLSIDEEEQAALAHLRSIQRRKEQAAAAATAAAREQALRQAAAARELATIQAREAREQALREAAVARQVEQARRKAYLDAVERRRNEYLQAQLIAQAQAQAQAQAQRQAVLETRRQAEINEAGRRCQARCQRRLVKTSECPRTSCYCHTPLHIEQDKTHTDSCGCDRSVPVPAPTASTPRHELQDLNNLFGSLFGFQLVPDTQNDEAAAPAPVPASNGETTSQTKTAPTETVAEKPRVEVEEAAPSTSATPAPAPPAEKKEKDFPEDINNLLSQFLGLRVDPLSGSDSSSVVKAKGHGIPEGLNELLGQFGLVFEPDSESKEDEKNEESAQAPAVTTETKQEIPKAAPAESSSSQPAESSTSTSKPESQKEVPPFTSLLGEFADVNPFLRDLLGNFEHALTDEWKKKGQQARGRGCARSCEKKDKGKGRAEGERKEVPKSSEIPTPAPAVPTSTPSISQSNETTDCSASVAALDSIESQLSSLKSNFTFPSKLAFAHSEGSSAPPLLFNKTNSTYHTQANAYLQLLLKADGITSNGDKSIRQRRKDLVRLVEQEIEKLENQRDELWKEVKEKRENGVESEPEEDEERSWSGSETTSVNGDHESENLEQKVEVEHVENAKKEEEEQHKSYADVAKADEIEAQPINETVKNVENVQDEPEGYTISVTFPPEEAQQEQKEEKVEEEKKEKVVEEDRKSDKSAKVEDEKDEAKEEGYELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9ID43</accession>
    <name>A0A1B9ID43_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_00636</name>
        <name evidence="3" type="ORF">I206_100689</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014553.1">
        <property type="nucleotide sequence ID" value="XM_019152415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9ID43"/>
    <dbReference type="GeneID" id="30169005"/>
    <dbReference type="KEGG" id="kpin:30169005"/>
    <dbReference type="OrthoDB" id="10599429at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF53334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC66784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="258" mass="29938" checksum="2D2F106401A84254" modified="2016-11-02" version="1">MSSDDDEYPPIPPPITRPEESDEREIVRFRTRSGYETILRRRKIDYRDERGSLSTSPVHFSWTNREGYVRFYDICEHNAPHGKPAECKIDHRRSVQLSEVAVEKIHPTDERYYAAAILPLNHVYLRHISGDSSRLSSVQNDCEGRSVADFMRKFQLHHDEYRQASVLYNQSASLENLTKEFNSKINKYGLPSCEFPDPSMDPVELGARLAQERHDTEEKVRSKFVGNPDVSTYLNRLTGQYFSDVIKTIDPNSQYYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9ID94</accession>
    <name>A0A1B9ID94_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amino-acid acetyltransferase, mitochondrial</fullName>
            <ecNumber evidence="5">2.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Arginine-requiring protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Glutamate N-acetyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">N-acetylglutamate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">I206_00954</name>
        <name evidence="19" type="ORF">I206_100371</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">N-acetylglutamate synthase involved in arginine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the acetyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.1" evidence="5"/>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014867.1">
        <property type="nucleotide sequence ID" value="XM_019152729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9ID94"/>
    <dbReference type="STRING" id="1296096.A0A1B9ID94"/>
    <dbReference type="GeneID" id="30169323"/>
    <dbReference type="KEGG" id="kpin:30169323"/>
    <dbReference type="OrthoDB" id="5585968at2759"/>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006592">
        <property type="term" value="P:ornithine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000070">
        <property type="entry name" value="Acetylglutamate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006855">
        <property type="entry name" value="Vertebrate-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342:SF4">
        <property type="entry name" value="AMINO-ACID ACETYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04768">
        <property type="entry name" value="NAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51731">
        <property type="entry name" value="GNAT_NAGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="17">
        <location>
            <begin position="420"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="64"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OCF53648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="WWC66469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="630" mass="71458" checksum="77E7BE31A496B7EA" modified="2016-11-02" version="1">MKIRIQGLLSPVKSSSLRRNGRVSANCIQFRYRHDSQLLRDIASEDNDFILSILQASPSVRDSRSYLSSFAPPPQTPIIPSTTSDITTTSTSTSNKTESQAENPLVNSLLNPIIRRPALVKIQGPFTDAQLDSICKGMAHLQKLGLVSVIVVDRDDLPTIESKDRFEAQRQRSIVRKEVERVVHFLSRHRSIARPIFSTVARINENDKDKNKNKNVIESEEEENEVFIEEEGLDHVRRAVMEGEIPVLLPVALDEGCRSRRISSNKVLLALAKSMSLSNSSNSSNTSNSNSNSNSKYDLTPLRLLVINREGGIPSYARQGLPHLSINLSSEFEYINKTFQNSWKDTHPTSLFNLKLSKECLEYMPPESSALIVSHRSSSSMIANLITNKPAHSASLPHSLINNSEGRITRDTPTIIRKGLQVRVLRSFKEINLKKLKDLLEFSFKKNLDEENFYKRLKNDLDFVIIVGDYSGAAICTLEGKSKFNEKEKTKKSICYLDKFAVNPKNQGDGTVDFLWVALRDETYGLGLLDASNPSIGSLKGVGIGRDLVWRSKSNNPINKWYFERSNGFKLTNDKKWKLFWCDAEQRLNSIWKEREFGGGRLIKVIENEEKNRLIWWENEISKIKSAWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IDN2</accession>
    <name>A0A1B9IDN2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Endoplasmic reticulum protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_01046</name>
        <name evidence="9" type="ORF">I206_100279</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PER33/POM33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014958.1">
        <property type="nucleotide sequence ID" value="XM_019152820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IDN2"/>
    <dbReference type="STRING" id="1296096.A0A1B9IDN2"/>
    <dbReference type="GeneID" id="30169415"/>
    <dbReference type="KEGG" id="kpin:30169415"/>
    <dbReference type="OrthoDB" id="5581259at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071786">
        <property type="term" value="P:endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051645">
        <property type="entry name" value="PER33/POM33_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005344">
        <property type="entry name" value="TMEM33/Pom33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03661">
        <property type="entry name" value="TMEM33_Pom33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="244"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="245"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF53739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC66378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="271" mass="30164" checksum="4220060A2B7A071C" modified="2016-11-02" version="1">MPAVDPHYLWAFGHGVMLLSASYVLLQTVLFRPEPTKSYKLAFTGALLSYSIVVYKSLGKPQLNQAWLRRALVDENVQYAILALYWWIAKPVNISILPFATFSLFHCLTFLRTNIIPKFVPPPPTGAQAQRPPVLLENISKKIQLWVKGNYDVAMRFVAYCELLICVRLILGVLTFRQSFIAPLFMVHFVRLRYHASPFTKSAISNVNNYINNFVSNKPPVIQNAWSTIKRLISTWGGAPLISSQGQTQQTAGPGAQGAQAAGTATGAGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IE34</accession>
    <name>A0A1B9IE34_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_01206</name>
        <name evidence="3" type="ORF">I206_100121</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019015118.1">
        <property type="nucleotide sequence ID" value="XM_019152980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IE34"/>
    <dbReference type="GeneID" id="30169575"/>
    <dbReference type="KEGG" id="kpin:30169575"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF53899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC66220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="99" mass="11182" checksum="D147D0C3CC7F9DB8" modified="2016-11-02" version="1">MGLYSFSSRKIVTRLKQSEHQNKTAEMRNSIILITLILSLSSVFGIRPLPYRRHHVKSLNSLKHRAPVPTITAPSLGPKDDLPPWRQDKRTIATAVARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IEF1</accession>
    <name>A0A1B9IEF1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Porphobilinogen deaminase</fullName>
            <ecNumber evidence="5">2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Hydroxymethylbilane synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Pre-uroporphyrinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">I206_01118</name>
        <name evidence="18" type="ORF">I206_100207</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="EC" id="2.5.1.61"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HMBS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="5"/>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019015030.1">
        <property type="nucleotide sequence ID" value="XM_019152892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IEF1"/>
    <dbReference type="STRING" id="1296096.A0A1B9IEF1"/>
    <dbReference type="GeneID" id="30169487"/>
    <dbReference type="KEGG" id="kpin:30169487"/>
    <dbReference type="OrthoDB" id="564646at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000005">
        <property type="entry name" value="Porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000086">
        <property type="entry name" value="Probable porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="entry name" value="Porphobilinogen deaminase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557:SF0">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="9" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobilinogen deaminase N-terminal" evidence="15">
        <location>
            <begin position="36"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobilinogen deaminase C-terminal" evidence="16">
        <location>
            <begin position="292"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="450"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OCF53811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="WWC66306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="480" mass="53517" checksum="C5285070A1BB0090" modified="2016-11-02" version="1">MTSSCPWHTNSTAINRRPIPDRDLLLAMKASANSFVLGTRKSNLALIQTGHVADDLRLLHNGPSSSSSSSNNTLEEEEEEEDSRMKFKFTIESMTTVGDRNQTTPLHLLSPYSSSQPAKSLWTDELEFKLINGHFDMLIHSLKDVPTVLKDGCEIGCMVKRHDPRDALVIKQGLPYKSLEELPDGSVVGTGSVRRVAQLKRAFPNLIFEDMRGNLNTRFSKLDNPSSPFSALILAMSGLSRVGMSHRVVSALSSPTLMHAVGQGALAVEIRIEDNRTRNCLLGLGHWPTEWTCGAERGCLRVLEGGCSVPVGVESEIIELQESDLENLNWEEIENPFKDELEEPLKKDSPMLHFSGIIDIPEKTTSLSTKTIFSKHSLPPLRKRFAKLSLHACVTSTDGTKHVLFEPKPVLVKSYRQAEKFGEECARKLRLMGASEILDEINLIRKAKEQEDLQRAIERSKLALAKEQEKNQSEETQVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IEH3</accession>
    <name>A0A1B9IEH3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endoplasmic reticulum protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_00986</name>
        <name evidence="4" type="ORF">I206_100339</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </evidence>
    <sequence length="663" mass="65731" checksum="7D030A99052AA5F9" modified="2016-11-02" version="1">MKFLSLVSILPLLATATANTPSDSKVLSSPRGNVSPSTNNLHGGLEARHSQPKWFMNKLKHFNRSTDQLATQVNLQEKEEADGKEFKKEKRNVIRKIVKRKKRAVATTCGVKTVTVTVTTSIVSATSPSNSTSATSSVNRSSSSSASVSKTSSVPSASVSKTSSGISSTSKASSTSGSISKSSSTSASASNASSTSGSASKSSSTSVSKTSSSSISVSTSKSSSASVSKSASAASSTGSKSSAISSSSSKATSAFASATVSKTSSTTSGSAKATLNRSSTSNSSAPSPTHSSVSSSIPKAATSTSNSKTASSSTSKAVSSSNTSSTKLATSTISKSSTSITASVSKANSSNASLSKTSSGIVTSSRSGTSSTSKAASSISKVASSTSKAASSTSKAASSTSKAASSTSSKAASSTSKAASSTSKAASSASKAASSTSKAASSTSKAVSSASKAASSISKVASSTSKSASATSKAASSTSKAASSTSKAASSTSKVASSTSKAASSSSNVASSTISLTPSTTSSSVAASPSTTSKAVSVDPDGDGPFYGWGTYFDVGLGACGWYNQPSDYIVAASAELFDNWPGYNGLNPNDNPICGHHVKLSWGGNSITAQIADRCPGCSKRSLDLSKGAYGALTNDNWDMGVMASWINGAAYNSDLEWEWLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8KZ83</accession>
    <name>A0AAJ8KZ83_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ras-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_100533</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014707.2">
        <property type="nucleotide sequence ID" value="XM_019152569.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8KZ83"/>
    <dbReference type="GeneID" id="30169162"/>
    <dbReference type="KEGG" id="kpin:30169162"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046580">
        <property type="term" value="P:negative regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05132">
        <property type="entry name" value="RasGAP_GAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF17">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="3">
        <location>
            <begin position="177"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="51"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC66630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="784" mass="89077" checksum="FA938C4767330198" modified="2024-07-24" version="1">MLTMTMTASSIPGGLASPSGSSNSHASKRLTNRMTNRYSVNAMYSLAAEQDVDLEDELARAQKRLRDLKSRISSQSKKNFVLERDVRYLDSRIALLIQNRMAADEKREVAETLEDVDEESGLWPDERKMNQYANLFFLLQSEPRHVASLCRLVSLAEIDTLLQTVMFTLYGNQYEQREEHLLLTMFQSVLSAQFETTTEFGSLLRANTPVSRMMTTYTRRGPGQSYLKSVLADRINSLIEHKDLNLEINPLKVYEQMIQQIEEDTGTLPPSLPRGVPPEVAAANADVQAIIVPRLTMLMEIANTFLATIIESMDTVPYGIRWICKQIRSLTRRKYPDASDASICSLIGGFFFLRFINPAIVTPQAYMLVDGVPAKHPRRTLTLIAKMLQNLANKPSYAKEQYMMSLNPFVENNKVRMNQFLNALCEVGDFYESLELDQYMALSKKDLQINITLNELYNTHSLLMQHMETLSPNEKHHLRILLDDLGAAPGQVPRKENRSIELPLYSRWETPIQDLSTALMSDSVTQNDINYMEAKSIFVQLLRSMPHLADKRPIDLPSLAERAATSKDPVLVRRGIKVQALLSELESAGVVDASDHFKIIQDEVAAEMVHLGNAKEKVVLETRSLEAVYKTICDHNNYLRSQLEQYKAYLQNVRLTSSKEKGSAGGVGVVTVNGKEKKQVKNQVLGPYRFTHSQFEKEGIIMESNVPENRRVNIYFNITSPTPGTFIIALHFKGREKPILEMDLKIDDLLEKQKDQQAMLDLEYVQLNVPKVLALFNKLFSKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L093</accession>
    <name>A0AAJ8L093_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_102092</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC68169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058603.1">
        <property type="nucleotide sequence ID" value="XM_070202502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L093"/>
    <dbReference type="GeneID" id="30175184"/>
    <dbReference type="KEGG" id="kpin:30175184"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF51">
        <property type="entry name" value="SERINE-ARGININE PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="3"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="142"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="155"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC68169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="263" mass="30561" checksum="CAFA614C0B1100E4" modified="2024-07-24" version="1">MSRRVYLGRLPLDAQKADIEDHFRGYGRILDLKLMGNFGFAEFESSRDAEDVIKDFNNRPFMGEKDTYEARPPRNSGPPRKGVRIAVIGIPGSTSWQDLKDYGRLGGNNIIYADVDRYNPGQGIIEYPTLEEAEEAVKRLAGVDINGSPNPAGADDARRGDSDRRPPPRDFDDRRSYNRGGYDDRRAPRDYDRRDDRRDDRRNDRDYGRRDDRGDRGYDRRDTRRDDRRDGGDSYAPRDRSPRRDNDAPRREYDERAPLPDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L3N4</accession>
    <name>A0AAJ8L3N4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_103386</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058851.1">
        <property type="nucleotide sequence ID" value="XM_070202750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L3N4"/>
    <dbReference type="GeneID" id="30169978"/>
    <dbReference type="KEGG" id="kpin:30169978"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="209"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC69447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="583" mass="64046" checksum="694275BD27B3E993" modified="2024-07-24" version="1">MAEYNVDGMFRASPQSSLRNIDSDNEMGDSTQKRKRLSLQEGLLGGTSSSGSSNSIDKGKQRSVTMGPLRASPEHDSSGENSKKGKGKGKVSATGLAGFTSCEACRRGKCRRFAIECIRVKAVRRKGPAPVAVSDAVHGYNHDSSLITSDTARRSSALSDIGGPDFERKLSASSNHSPSYPLASPALSINNLPDGIDQVVPGPTIDSILNLFFDYVYPLTPCLHRPTFVADLTARRDRTDPVFFALAMSVIASTLVQIPRSLVNLDKNEVENLARKCIQVSRAKMGHMWEDATPITSSMVVISYLEGIVYLFLGNNTAHVVATAQANQLALALRLNEESSYEGLDMIEREIRRRIYWRARSICLPLEDAHDLMLPAEVDDDMITPEGILPQPPGTTPLITGFNVNTHLFRILNDAILIQRRKSARSMEEILTDLQRLQDLRNRTIQTFLTVPDPLRMRNAYDTRSASFLVMQGNILVTQHVVRLVLLQTHQALLAMLAVMTPILPPPIGAEETPENIALPVECVATNGPSLVQKVRFVGIHLMEATNDPTGTQSHSQKLLMQFLSVLSVIEGMYTFGRDISAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L3R0</accession>
    <name>A0AAJ8L3R0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ras family, other</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_102721</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058715.1">
        <property type="nucleotide sequence ID" value="XM_070202614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L3R0"/>
    <dbReference type="GeneID" id="30171444"/>
    <dbReference type="KEGG" id="kpin:30171444"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC68786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="23070" checksum="D4146B579EB0D3ED" modified="2024-07-24" version="1">MRVFQCAVMGSGGVGKSAITVRFINGSYLEWYDPTNRKQFNVDNQPCLLEILDTAGIDQYLTLNDMFIRESEGFILVFSLCQRDSFEEVLRTYDAIQRIKLSEGGRIIPIVIVGNKSDLIDEREVDTTEGEKLSLNWNCSYYETSARTSININSVFEDIVRQLRKNELSKRQEKNKDYLNNNYNISRRKRIKTKKCVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L400</accession>
    <name>A0AAJ8L400_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7729 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_104127</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059006.1">
        <property type="nucleotide sequence ID" value="XM_070202905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L400"/>
    <dbReference type="GeneID" id="30172666"/>
    <dbReference type="KEGG" id="kpin:30172666"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056146">
        <property type="entry name" value="DUF7729"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34862">
        <property type="entry name" value="SPARK DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34862:SF1">
        <property type="entry name" value="SPARK DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24855">
        <property type="entry name" value="DUF7729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042561136" description="DUF7729 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7729" evidence="3">
        <location>
            <begin position="33"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC70179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="266" mass="26494" checksum="AC81A33E7BC8788F" modified="2024-07-24" version="1">MHARSALIAVVASTSYAAAGCTTQVASLALGDLGSCLQLTTLLPVLSAGTNDSITSTLNTYLTSLCSSSTPTCANGTLTSAQSSINSACSSDFSAGGTEAIEIKGLVGLLGNYNEIYTAGCSKNSTTNDFCVVDALETVSNATGQSVTISYITSLLSGDSSVLSGLESVFSSGSLCTGCVSGIYYEVKQVNSSIATSSYGQALNQKCGSNFGSTALNSTNTSTSTSQTSAASSSGSSAGELTIPYATFGVIGGMFSALILGAIVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L4T1</accession>
    <name>A0AAJ8L4T1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_103497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013432.2">
        <property type="nucleotide sequence ID" value="XM_019153271.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L4T1"/>
    <dbReference type="GeneID" id="30169868"/>
    <dbReference type="KEGG" id="kpin:30169868"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC69555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="377" mass="40789" checksum="95ACA295E2EF2036" modified="2024-07-24" version="1">MPVTKKKGSLFAIYADTPDKSSSSASSSSSSLSIKTSKTGTTSPSKRSSSSSRKALTSLQPKALESTKTENKGKSVSLQDENSKSKISTSDLLPLKSKLSEFTNKSHTHSHSAPTKNRTKSSIQIFNDENSISVKTSRKIPTTTLKSSINTITSSPKSRKSAPTPLATSHNQSTKRTRDLLSPLPILDVSSSSGASHPRPKDKFENRLNDLNESPLKRNKISPSQSRNTIQQGIEINDKENIPPVFSPDSSNDSPASRTRSKIRSLTLSSGQSPLSSRIQSSRKEINKFGELIGDGKSTLTLKKGRELSGLLQQDLDQNLENTIKILQPSPTKKSGKSTSTTIKDIDMLGDVSEAYGAERNNEPEGFKTQRVSISGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L542</accession>
    <name>A0AAJ8L542_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_103706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013228.2">
        <property type="nucleotide sequence ID" value="XM_019153067.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L542"/>
    <dbReference type="GeneID" id="30169662"/>
    <dbReference type="KEGG" id="kpin:30169662"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF7">
        <property type="entry name" value="ZINC BINDING OXIDOREDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="14"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC69763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="359" mass="38637" checksum="88F25DB28E215AC6" modified="2024-07-24" version="1">MSVEIPKTIKALVADEKASWATVKEVPIPEIGENEVLVKVAYVSLNPTDWKHASFVSVDGVTLGCDFSGEVVKLGSNLKTPLQVGDRVAGSVHGGIYKDKGSFAEYLKAESDLIFKLPEQTKLEEAPTYGIGWGTAGHALIHSQGHEYPPSKVDAGEWYIIYGASSSVGLFAVQVAKVLGYKVLAFASPHSFDLVKSYGADHVVDYHDEQKAIKEALEVTGGKGAKFGLDTISSGNSYKIAIGALGEKGYQLNAILLLPEDAKSINPKVKIANTLLYTIQGREFNFSPRKKENPNIIPALPADRAFGAKFYAATPEFITKYGIKPNPIALRGGLDTITSGFEELKANKVSGQKLTHKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L7C1</accession>
    <name>A0AAJ8L7C1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_105477</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059236.1">
        <property type="nucleotide sequence ID" value="XM_070203135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L7C1"/>
    <dbReference type="GeneID" id="30171989"/>
    <dbReference type="KEGG" id="kpin:30171989"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="6">
        <location>
            <begin position="110"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC71519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="250" mass="28593" checksum="711B8B3158775C00" modified="2024-07-24" version="1">MAPFDLDACIDRLRDKQLLGEALLREICEKTKEVLMRESNVVHVASPITVVGDIHGQFHDLIEIFRIGGSAPNTNYLFLGDYVDRGLHSVETISLLTCLKLRYPERIHLIRGNHESRAVTQTYGFYLECTRKYGSPAVWQYFTDMFDFLTLSVVIDDAIFCVHGGLSPSIHHIDQIKIIDRFREIPHEGPMADLVWSDPDPEKEDFAISPRILEVSPGGRRYFNVFNAAPENERDGPNQQQQVKAIEYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L8G7</accession>
    <name>A0AAJ8L8G7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquinol-cytochrome c reductase subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_106079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010434.2">
        <property type="nucleotide sequence ID" value="XM_019156632.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L8G7"/>
    <dbReference type="GeneID" id="30173272"/>
    <dbReference type="KEGG" id="kpin:30173272"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019182">
        <property type="entry name" value="Cytochrome_b-c1_su10_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28254">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28254:SF1">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09796">
        <property type="entry name" value="QCR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC72119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="74" mass="8165" checksum="BA10E2D29080EA95" modified="2024-07-24" version="1">MPAFIRRSQIGLAGLTPERLRGWTTPLMFWGVAAGGAVSLFLSDVPLFRKDVLIKVPVVGNYFVDKTPDSDKPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L8W2</accession>
    <name>A0AAJ8L8W2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I206_105190</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059175.1">
        <property type="nucleotide sequence ID" value="XM_070203074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L8W2"/>
    <dbReference type="GeneID" id="30172270"/>
    <dbReference type="KEGG" id="kpin:30172270"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="BCS1 N-terminal" evidence="15">
        <location>
            <begin position="31"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="291"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="360"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="WWC71237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="681" mass="76391" checksum="BB5A50F28AD28D32" modified="2024-07-24" version="1">MGTINFLRRLLATLLGGFQDSPLLLDGFRVAMAGMFFEFSRRFSNGILAKLFDSIYLTAIISSDDEAYDWIQYYMNIQAPIIYDNSIPTSSSLTEAEHQNMYSLKTTLKEIVWPMGKAAPRQIMISTGVGNNRISIPPWMDGAAYESTDSLDENEEMERDVRLNIEPSSGDTRLIKFNGQSIRFVIKPDESRGNVTTHQRKWLIMWTFLGTHDTFTSLTQEARRLYITKISKRTISIFSPDPGNRWYRSASRPMRSWDSIILPHGVKEWLLTDTSEFLAEREYYEQRGVPHRRGYLLYGEPGSGKSSLISALAAKLKLDIYIINLGSRMIDDDSLNSLLRSCPSRCLLLMEDIDCAFSKRQSSTQSEGTSENGENQSNEANPIEENHMAMPNINPRLVNKRGRQGHFAGMGMSEPGSSVTLSGLLNALDGVASSEGRLLFCTTNWKDKIDPALSRNGRCDVWIEFSHATRAQAKDLFVHFYKNDSNPYNNNQNNIPDLADTNHEVEIKTMAISPNRLSSLAEQFASAIPLNKVSVSALQGYLIRHKRNPVEAVEGVKQWVETGFGQGPTMFLKDGKLEMKDLKPSPNRTSSETISLPNHEVNPKVIDLNALNNSVLRSHDQIGNRPSAQLSKEADFKDLVVNGKGIENIPNGHVVNPNEGLMKRARTHLRVLSRSKMGSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L8X2</accession>
    <name>A0AAJ8L8X2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">General transcription factor TFIIB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_106843</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC72879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059517.1">
        <property type="nucleotide sequence ID" value="XM_070203416.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="30173980"/>
    <dbReference type="KEGG" id="kpin:30173980"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF13">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="7">
        <location>
            <begin position="23"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="374"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="375"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="426"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC72879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="436" mass="45722" checksum="9C775953AB7A9C6F" modified="2024-07-24" version="1">MALAGPRQPGPKFGQSVAPNLNVRHLCPNCRTDPPNIIEEYSKGDLVCGDCGTILGDRIVDTRSECGYYSIKLACLYNLADIDSQGTFAGDENGDDPSRVGDAGNPLLGSNHLDTVISHKDGRSGIARDLNRAVQRANNLSNGINGKTNTAVLSAVFSRIGEKCDAMQLPRGVRERAQHVYKIADDQKAIKGKNEPAIIAACIIYACRDAGAHRTFQEASKALKISKKELGQVFTVIKNAVQASGTKTGGLSDGSNNAQESTEALLGRFTNYLDLGNAVFNASKHIAAEATAKSTIDGRSPVSIAAGVLYFTCVLLSKNASAKDIAGMGGVSESTTKLICKMVATKLDDVIRPEWKTEYAPGYAQLAQLGRINDSARNSRSGTPSKSLKTPVAQAQSVNGNANGEAKTPKPEGSVNGDANGEAKVNGDANVNGGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L8Y1</accession>
    <name>A0AAJ8L8Y1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_105220</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059186.1">
        <property type="nucleotide sequence ID" value="XM_070203085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L8Y1"/>
    <dbReference type="GeneID" id="30172240"/>
    <dbReference type="KEGG" id="kpin:30172240"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16461">
        <property type="entry name" value="RING-H2_EL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000728">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.4, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051653">
        <property type="entry name" value="E3_ligase_sorting_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47168:SF1">
        <property type="entry name" value="OS02G0798600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47168">
        <property type="entry name" value="RING ZINC FINGER DOMAIN SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="888"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="175"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="352"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="481"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="544"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="578"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="621"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="717"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="937"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="481"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="621"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="717"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="745"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="773"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC71267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="979" mass="104924" checksum="218A6357EEB7CEBF" modified="2024-07-24" version="1">MGSSHSQLQRNPSSPSAAQSPSSPPPTNTRHFRFNSLRRFSNLGRRNNDASTNSKRLRQGSTTSDSLSPRTGSESGGREEGKKKKARASSPVAPNPIPEEISIASPKSTLPPAPESSDQVMEDNVEATSSSSMQTSAHAPTLAEPIQTASIISRSSPVCSAVEAPPIQQSILLTPTAAPIPLPTTPSSEISDPLSEERRQSLTLIRDTLGPEWQANSTSPSSSSAGRIFDHFRRTSSSPDLNDQSGSEGRSIPQRTMSDRLTALLGFSTPGISSEAPQREIPTREPTSSIDDADRRLEESESAIQELTERLTQAREELAQTERQLNDAQDRVERRRVTPGAVLIIQGLAQTHAQPSFEDESVEAGNAEGNEPRRRPGMRARRSSEGSTSHPRRGFRNQSRDSDNRSNIETQARMIGGLLTVTAAATATTLLAPSSPPFPPANPRSPAASALEAIVNRIRPRQNRTQTVEAALGNYLRTAIQGSNDRPFSTNPTVSPAPEGEGGSTANADVIASEFQRFLEGVQGDLVGAVREFAGPLPVNLTTSASPALDAQPEVQLDGASSETVEMQDVEMRDVAEEDSFVTAPSTAPTPIPPSPSDDHEGATSNILPVDPIVPTFHSQLGQNLPRDSTAPTPQVTGGTDGQPRRLNFFRAHMFPPLPSTSSPLEDNATANQPIVPCIFIGVRSVRHDPNMTTDELAEHPNFPFVDGQAATMSPVSAAATTPLASPSDLSTTATDDGSAGILDSGSTHTSPSLQSSALPDMSTSNISSGVSTERRSLRERVLDRLNPSRTRRHDNTIGEGPLQTYLVYVIGGNYPQNHPILSIPSLITGGPLTDEEMNLISELMGPAKPPTVDNEEIQKSGLKVVKGDQMAQLTEKGELLDICADRCLICLSDYEPEEECRILNCKHGYHKECVDQWLIKGRNSCPACRSEAVDKTKSPTISTSADHATEELPIVNQDTSLPMDIDQVDSAAETNNVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LA96</accession>
    <name>A0AAJ8LA96_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_106136</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:protein serine/threonine kinase activity"/>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MLI3</accession>
    <name>A0AAJ8MLI3_9TREE</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="3" type="ORF">I206_101793</name>
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        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
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            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <end position="146"/>
        </location>
    </feature>
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        <location>
            <begin position="207"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="522"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
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        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="307"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="433"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC67876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="557" mass="61390" checksum="D8E81C944DF361F2" modified="2024-07-24" version="1">MPDLFDPYLTPPPSRRTSLAYDALPQSKHLFSKHRSSLVDTISGACDNALSFRRHSLPLNARFRLPPVILAKDDSGEAAEGENDEDVRLDGRADKRRRVTKGGKSVDAVPSPRKDRSGEGSASTSPPRLGTATSQPSRNGRPLALAPIKPIGFAAAREARRDDNGNQALPSPVVMGFDFKAIDEDQLKTVRDTISIKEQQQALIAARRREVAQSQPSTPKELTFKGWAPKDPSNNNTNNSLPPHADNVTNSINSRESFSGPSTSGSNPLSGGGGVGRRREKTRDKVEKMSIVTSATERDVVPGSKSAPLNHQGLASQQASPREPPSGSQTSVPPHILPPLQDYGHHGSGLTDPRTAPIGHRSRNGEEHEFARQQGPYYNLPQTRPLGRPYESQGNLRGPATVSDRRNFSVPQIPPSASTRYEPGVPSPRRSSLHQSSNTSPSSSSPRVSRETFLQPFNQLYDLIYTQMDSYRYQLGDLHNRYESLYSQQLTQMNEFKNTANASNTLLGNLQQSADSLKDMVRYEVERNNSNKDREIEELRERLRRLEERDGGENGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MLN5</accession>
    <name>A0AAJ8MLN5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_100631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058344.1">
        <property type="nucleotide sequence ID" value="XM_070202243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MLN5"/>
    <dbReference type="GeneID" id="30169063"/>
    <dbReference type="KEGG" id="kpin:30169063"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Beta-glucanase-like"/>
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        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GH16_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042559540" description="GH16 domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="31"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC66726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="347" mass="38486" checksum="ADAFBF18BFE7EA5C" modified="2024-07-24" version="1">MLHLISRCSSYLIFALPLLNSVLAATYTLSKTWKGNDFFQGFTWWEWDDPTQGRVNYVNQETAIARNLSYVNGDNFIMRADSTNVVDPSARGRDSVRIHSKETYTDGILIIDVKHMPVGCGTWPAFWTCTRNGPWPTGGEVDIIEGIYGINQQYSNNLFTLHSDAGCNMPPASGQNRGTGTSLLNDCTGGVGCGVRDTSSKSFGEEFNKGQGGIFVMRRSHTRGFSFWFWPHNSPKAPSDITTGSNVIMESNLNAPIANFPADQCDINRHFDDHEIIINLTFAGSWAGATPQWSASGCAGSVGWTPDDYVDKNPQAFSEAYWEIRSLKWYTPVCAVKARKRALDSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MM52</accession>
    <name>A0AAJ8MM52_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_100629</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058342.1">
        <property type="nucleotide sequence ID" value="XM_070202241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MM52"/>
    <dbReference type="GeneID" id="30169065"/>
    <dbReference type="KEGG" id="kpin:30169065"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF4">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC66724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="506" mass="56426" checksum="F5CD38550BBFE754" modified="2024-07-24" version="1">MENPIQSSIAGNQIATYKPNLAVEHEDVHVDLTIDRERYKVETSRWRRIRQHSLTQMLFISIQAFCGPALSDAISGLGGGGLATPKTSNIRFALDQGVEAIVCLFGAVLVNIIGVKWSLVIGAASFPLLGASYYCNSQFENQWFLILTAPFTGIGFGFWNISEGAYVMSIAPEAKRGKYLALWIVSRNAGQLVGGAINLAKNSTKDAGGGIDPSTYIPFIIIEALALPFAFGICEMKDVVRSDGTKILILPKLKNFEELKYILKTYLSKIIYCSFLFIIWSYFYNGPWSTYLALYFSVRSRSLSSLISPFFCIIGCFGLGFILDLSNKNYSQRKRAQFGFWLIIFLNLLVYIWSLIIQIDFIRNNPGSIDWNDKKFLKSFLPYFFIQTTGPLAQVYTYWILSSFAESGQDNIRFSAALKAIQCVGNAIAFGVSAADSFPLTGMILNCSLMVACIPGMWYITSKTPDRIPADVIAEEMILERRIKMEDPGQKDALDQVHTREVATLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MP11</accession>
    <name>A0AAJ8MP11_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_102350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mohammad A.W."/>
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                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
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</entry>
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                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
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                <person name="Heitman J."/>
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                <person name="Heitman J."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Alvarado L."/>
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                <person name="Imamovic A."/>
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                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
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                <person name="David-Palma M."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
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                <person name="Priest M."/>
                <person name="Roberts A."/>
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                <person name="Shea T."/>
                <person name="Sykes S."/>
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                <person name="Nusbaum C."/>
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                <person name="David-Palma M."/>
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                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
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                <person name="Cuomo C.A."/>
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    </evidence>
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        <source>
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</entry>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
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                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">CBS 10737</strain>
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    <reference evidence="3" key="2">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
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                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
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                <person name="Imamovic A."/>
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                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
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    <reference evidence="2" key="3">
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            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
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    </reference>
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            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
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    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700119">
        <property type="protein sequence ID" value="OCF46152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC66107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A1B9HSA0"/>
    <dbReference type="STRING" id="1296096.A0A1B9HSA0"/>
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    <dbReference type="KEGG" id="kpin:30176191"/>
    <dbReference type="OrthoDB" id="1882297at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:negative regulation of translation"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="60S ribosomal protein L13a"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_uL13_euk/arc"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
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            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
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            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCF46152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC66107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="199" mass="22537" checksum="97CDAFB0ED322BC6" modified="2016-11-02" version="1">MSNFSAQPIVIDGKGHLLGRLASIISKQILTGQKVTVVRCEEINVSGSFFRNKLKYHNYLHKRHIVNPKKSGPFHFRAPSRILFKAVRGMVPHKTSRGAAALKRLELFEGVPPAQDKVKKMVVPAALRVLRLKPGRKFCTLKRISAEVGWQYKDVVDRLEEKRKVKGQAYFERKQAALKLRAKADSSVAKNETLTQFGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HSZ0</accession>
    <name>A0A1B9HSZ0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PWI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_07620</name>
        <name evidence="8" type="ORF">I206_102250</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894017">
        <property type="protein sequence ID" value="OCF46386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007605.1">
        <property type="nucleotide sequence ID" value="XM_019159311.1"/>
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    <dbReference type="KEGG" id="kpin:30175989"/>
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        <property type="component" value="Chromosome 3"/>
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        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036483">
        <property type="entry name" value="PWI_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052768">
        <property type="entry name" value="RBM25"/>
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    <dbReference type="InterPro" id="IPR034268">
        <property type="entry name" value="RBM25_RRM"/>
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        <property type="entry name" value="RRM_dom"/>
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    <dbReference type="PANTHER" id="PTHR18806">
        <property type="entry name" value="RBM25 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18806:SF4">
        <property type="entry name" value="RNA-BINDING PROTEIN 25"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF01480">
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00311">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PWI"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="153"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="PWI" evidence="6">
        <location>
            <begin position="680"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="355"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="543"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
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            <begin position="31"/>
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        <location>
            <begin position="364"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF46386.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC68325.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="778" mass="86975" checksum="33C04AB8A99FB6BF" modified="2016-11-02" version="1">MYNGQPPFRPPGNIPPFPPNRPPAPGQAFPPFRPPPPGSFIPPPFPPNFSPGSRPPPPTLPHSPAGIPQTPGYDSPSSSSNGLNFRPPPTGPGGIGYNQYPPPRPAHPGLGLPPLPAGLPQPPKFPTPDSPSQGGGQGHNGAPPGFVRDVKTTSVFVGSIAPGIDDETLKNLLNACGPLHELKRVSGASGKPQAFGFAAYENPEVVLRCIRCLNGVELPDLTPEGRRDNKKKALVVKADQKTQEFLEEFESTLGRSDTDEEADAATRKSISHIVALLIDPSANLTDAPTKQGGGDSPLQVIVPAHLQDLQEGDLPENQRVAVLDQIAIFREASARREKEKKQIEDEKERFRIMQQHQNQRTPMNNNNNSNYGYGNQRGLARQQQQQQAEQSRHHQSPSGMGGQQTPQQNGNGAGPSRTRDPQGYDRPVGFVPAQSAEGKIDSGRTDEEEEDLRRQRRQREKDIALRDAERRVEHRERIRIEALNRELAQRKAHEDLIERNRKRLEDQYENWDDDEIIEKGRELFYTDRATWRARRQRARQQEYQDDVRDRQQEEDELQALERESEEFLKRQMAELAELEVEQKAKGLLTEDAAPIKLNLNIPAPAPEVKVKEEKKLVVPHKPIVLAGDEEEENEQKKKRTFIRLDNDDINSGDGLTQAERIAKRNAKLLEIKKGLPERRRDIFKSSIDWAGINETLISQKIKPFIEGKINELLGELDADLVEFVIEQVKEKKGSDDLVDGLEPILAEEAESFVVQLWKLLIFESEAFKIGLSTGAMMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HT41</accession>
    <name>A0A1B9HT41_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_07669</name>
        <name evidence="7" type="ORF">I206_102299</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the GSE complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894017">
        <property type="protein sequence ID" value="OCF46435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007654.1">
        <property type="nucleotide sequence ID" value="XM_019159360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HT41"/>
    <dbReference type="STRING" id="1296096.A0A1B9HT41"/>
    <dbReference type="GeneID" id="30176038"/>
    <dbReference type="KEGG" id="kpin:30176038"/>
    <dbReference type="OrthoDB" id="26136at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF2">
        <property type="entry name" value="GH16429P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="289"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCF46435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC68374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="399" mass="46015" checksum="A0058F13A0265202" modified="2016-11-02" version="1">MSRTPQNGESSKSKRDDDSHRTKILVLGWRKAGKTSCIKTVFQGVPTKEVPYFGVTQKIEKINYDSIVPIQIWDTPSNFELDQLEVPINTFSTIVYVLDMQQDDSYHESILRFVHLMIRIHLINSSIKFHMFIHKSEVLSEDYRGENYAEIQRTTSEEIEDFPFKSLQQQQQGGIGIDLEDQQNINLIINNLISDVRYSMTSVHDVTLRDAWSRVLQGSMEMLPAVESLLLDFTSHSSADNTFLFDINSGVILATDNRHRTDDLSEQVTEYLSSFLAFRDLYKNIRKAKSPSNGDANHEADKAEDTNPDGEENTEDDEEDEEDEDDGPRGWWDDEDPDEPWMTQSTRLMPNTTLALWQFTPYLALVVLLRTETWQARRGTIEYNLTFLRQGVREILSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HTH0</accession>
    <name>A0A1B9HTH0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_07417</name>
        <name evidence="3" type="ORF">I206_106694</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
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                <person name="David-Palma M."/>
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                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="13">CBS 10737</strain>
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                <person name="Litvintseva A."/>
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                <person name="Sun S."/>
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                <person name="Dromer F."/>
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                <person name="Zeng Q."/>
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                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
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                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="Dromer F."/>
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                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="Shea T."/>
                <person name="Bowers K."/>
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                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="biotinyl_domain"/>
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    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
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    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
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    <dbReference type="InterPro" id="IPR050856">
        <property type="entry name" value="Biotin_carboxylase_complex"/>
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    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
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    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866">
        <property type="entry name" value="CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866:SF33">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0092">Biotin</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="12">
        <location>
            <begin position="72"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="11">
        <location>
            <begin position="191"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="10">
        <location>
            <begin position="681"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCF46705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WWC72587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="756" mass="84258" checksum="389E4B030DEA61D8" modified="2016-11-02" version="1">MRAIARNTRPVIRHPSAAFIPPVLTQIRLVRPRSTTLLGVRYLATINTSLVSSPTHSDPLVGVQLSTSVKPHFKKILIANRGEIACRIIRTARKLGVKTVAVYSEADKDCIHVKMADEAFCIGPAPSTESYLNIDKILAVAKATGAQAIHPGYGFLSESSVFAERIKDSGLIFIGPPTSAIKSMGSKRESKEIMIAAGVPCVPGYHGSDQSSEALLKGAEQTGYPLLIKPTHGGGGKGMRIVRDPKSFQDELESAKREAIKSFSNDEVLLERWLEKPRHVEVQVFADTLGGCVALWERDCSVQRRHQKIIEEAPAPGLSPELKKDLAEKAVAAAKAVDYVGAGTVEFIMDAETGEYFFMEMNTRLQVEHPVTEMVTGIDLVEWQLSVAAGNPLPLTQDQIPCIGHAFEARIYAERPESNFLPDAGKLLHTKAPVNVPHRLETGFWEGDEISSYYDPMISKLIVHGSDRSSALSLLRSALDEYQVVGPSTNIEFLKNVISHKVFNAGPVETSFVQTYQEDLFPIKKIPNEILAQAALYLLLRNEKEFKSLNNNKLWFQLVNRRFGDNDNNNIKSFKINNKNIKIQIKEFEYIIKINDNDKKEEEEEIFINSTSELLKNGDNNEIISIINNNYNLKSTIIPVLFKNKFAEEFEKLHIFNNSFHYILSNQTSLIKIENSNSLNSSNSNLSKELISPMPATVIDIKISKGEKVKENQILIILESMKMEISIRSNKNGIIKKINVNKGKVVEEGEILVELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HTZ2</accession>
    <name>A0A1B9HTZ2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_07122</name>
        <name evidence="3" type="ORF">I206_106320</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894015">
        <property type="protein sequence ID" value="OCF46735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007954.1">
        <property type="nucleotide sequence ID" value="XM_019158816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HTZ2"/>
    <dbReference type="GeneID" id="30175491"/>
    <dbReference type="KEGG" id="kpin:30175491"/>
    <dbReference type="OrthoDB" id="10587015at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF46735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC72358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="663" mass="75337" checksum="4BB442BB3D98749E" modified="2016-11-02" version="1">MTEPNLPYGRSRYFPFAENPINVILEDQINSHQTSRHNNVAQSAQGIIDYSSSTQPYQDMGCQGQQYPLGPAIDFGSANHPTPSSSNDQTIQSQQVNQIPIFSSLPYSHNTTSHKATSKANFQNYTKDRNIVNNGDDEDEEGEEIPLEIELSEKSSYSPRNDRSKTTVISLKEFTKSPSSTIEMPLYANTPKIANIPPKRPHTSKFNTDSSSSSLDHEYIVRCDEPISTNGRYPTRKSTIRANEKVQAIRNCTERFSGSEDERIEAKKDKSLRKGQGKAKVGAYGGRRIPAGEGIYNDGTINRKAQKIPAGAFLFQLMEYLAYDKYPGYVIMKNQVAFIPNTEAFAKFVYSRDIKDHEKSKAITRPWESFQRNLNNYIASWPFHRLAVPGTKLKSQIIDIPTLNELAERWKEYGLDENVLERERNRIEQWAEITVPVKPYILSAKEKKTLKLVQFKRRFGKSSKLIDLDIAFKSTDKKERKYKIDEIDQNDEDEYYGPKKKRSRTTLIGESSGYYNQKEEKSLSVTIDDEEENNELYSEEDTEMMAPDLTETRASSPEIPLFNRIQANRMGTPEKMQLRLSIGGKSISIPSTPEKAIINSDKRSFASINSNSPDKGQHDPTYHEIIYTPSPTFSNPIVTPQTANTDVHSSSRPNSIMKIYCEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HUX2</accession>
    <name>A0A1B9HUX2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Exosome complex component MTR3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_06832</name>
        <name evidence="13" type="ORF">I206_102075</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700117">
        <property type="protein sequence ID" value="OCF47058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC68152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008277.1">
        <property type="nucleotide sequence ID" value="XM_019158531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HUX2"/>
    <dbReference type="STRING" id="1296096.A0A1B9HUX2"/>
    <dbReference type="GeneID" id="30175201"/>
    <dbReference type="KEGG" id="kpin:30175201"/>
    <dbReference type="OrthoDB" id="2504340at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11371">
        <property type="entry name" value="RNase_PH_MTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF2">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT MTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="10">
        <location>
            <begin position="42"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="11">
        <location>
            <begin position="185"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCF47058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC68152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="265" mass="28443" checksum="1586F41DD5A810F8" modified="2016-11-02" version="1">MATAFDRRRIPAPEVSIPPIYEPLDEEPEAGPSKRVDRGNEEARPIFLKTGLISQANGSGYIESGGVKIACSVYGPRPKAPPYTPQGTLNLEIKFAPFASDPRRAPLRDTEPIHLSQLLTQSLIPAIQLEQFPKSSIDIYLLILESDSTSNVISSGLTVASSAIADAGIPMNGLSTGSIVISNKNGQILVDPEENEEKDQSGKLLIGVLPALGKLTNLYMEGELEIDQAIQMIEQAITASRDTHTVLAQSLLEGAQERGLSGEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HV18</accession>
    <name>A0A1B9HV18_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_06887</name>
        <name evidence="4" type="ORF">I206_102021</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700117">
        <property type="protein sequence ID" value="OCF47111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC68100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008330.1">
        <property type="nucleotide sequence ID" value="XM_019158584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HV18"/>
    <dbReference type="GeneID" id="30175256"/>
    <dbReference type="KEGG" id="kpin:30175256"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="184"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF47111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC68100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="292" mass="33759" checksum="DA7F172DAA15D955" modified="2016-11-02" version="1">MSFSFKQVPSTDKRIKYISRPVRLDAEQIESVLVNGMASYRSTCTGYMLQRSEQPKSACRDMYLHFLCSAYDTELFPSNDHNVRDFPSDPLRVAETRFVDPRCEVFVTCTFNGIQSVIAFDTPGTQEMSRLWREWKGGDPDYRGRSLEKLHSTRRDWANNTYFPSLDKIKSRMETEHGLTSDNSIYANFLVTSPWAQGKGLESQLLQKLEETADNTQSTVWLIEDNQDNIELYTGRGYGKQFEEFIPFNAEGEQGEGTNHTVMTYKPPPHERPRRTYRRSKTAECMAYCLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HVK1</accession>
    <name>A0A1B9HVK1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">rRNA adenine N(6)-methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I206_07075</name>
        <name evidence="14" type="ORF">I206_101835</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>adenosine(1779)/adenosine(1780) in 18S rRNA + 4 S-adenosyl-L-methionine = N(6)-dimethyladenosine(1779)/N(6)-dimethyladenosine(1780) in 18S rRNA + 4 S-adenosyl-L-homocysteine + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42780"/>
            <dbReference type="Rhea" id="RHEA-COMP:10234"/>
            <dbReference type="Rhea" id="RHEA-COMP:10236"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74493"/>
            <dbReference type="EC" id="2.1.1.183"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8 9 10">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="10"/>
    <dbReference type="EMBL" id="KV700117">
        <property type="protein sequence ID" value="OCF47296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008515.1">
        <property type="nucleotide sequence ID" value="XM_019158769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HVK1"/>
    <dbReference type="STRING" id="1296096.A0A1B9HVK1"/>
    <dbReference type="GeneID" id="30175444"/>
    <dbReference type="KEGG" id="kpin:30175444"/>
    <dbReference type="OrthoDB" id="74991at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052909">
        <property type="term" value="F:18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000007">
        <property type="entry name" value="rRNA adenine N(6)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF7">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 10" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 9 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 9 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA adenine methylase transferase N-terminal" evidence="12">
        <location>
            <begin position="58"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCF47296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WWC67917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="324" mass="35526" checksum="F6AE42A54FD4CC23" modified="2016-11-02" version="1">MPKATTSTFRTAPTSAASRPKKNGESSSSGAGGAAGGARNHLFDTARFGQHILTNPLVAQGIVDKANLKPTDIVLEVGPGTGNLTVRILAACRKVVAVEMDPRMAAEVQKRVLGKPEQKKLEVMIGDFVKADLPYFDVCISNTPYQISSPLVFKLLSHRPIPRCAVLMFQREFALRLVAPAGTKLWGRLAANVQLYARVEHIMKVGKGNFRPPPQVESSVVRIMPRDPPPPVKFEEFDGLNRVIFSRMNKTVRANFKAKGVAELAERNYKTWCAEQGIIIEDGFDIREKIDNILLEAGYADDRAAKMDVDDLLKLLAAFNVAGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HW83</accession>
    <name>A0A1B9HW83_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_06434</name>
        <name evidence="9" type="ORF">I206_101596</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008752.1">
        <property type="nucleotide sequence ID" value="XM_019158139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HW83"/>
    <dbReference type="STRING" id="1296096.A0A1B9HW83"/>
    <dbReference type="GeneID" id="30174803"/>
    <dbReference type="KEGG" id="kpin:30174803"/>
    <dbReference type="OrthoDB" id="10009287at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF161">
        <property type="entry name" value="RECEPTOR EXPRESSION-ENHANCING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="30"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="111"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="363"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="59"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
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            <begin position="376"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF47533.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC67684.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="444" mass="47676" checksum="1EA2712D7997916D" modified="2016-11-02" version="1">MDPTTFAHVDHSGYTNADLTAKQPTVYETSGLTTSTIPPGAAPPHLGAASEGFNNPFETSNTSNNPFTNSKSSSSPPTAPVNPIKQSYPETQIYRETQAGQSDFADIHARSTTSDRNTTEGTARQNLSDATTQASDKANEVTTQASNKVNEVTTQASNKANEAASQASTKASQFSEQVQQKANEAATGIRQRVRKLSVDLNNAADHPAVKNAKGTANNYIAQFREQLGRSETIRDLEKRTNVDRVVLVVGGVLGYILLIPLNILRLALPITDLLTILPATYLSAIIIDKPETTANDQQVKSLLSFFVVLGAIQTLESLMAGVLENRIPQYFTIKLLFLAYLLHPRTQGATQVHEKVFKPLLASAQRSSKQAPPPSSSTYPAPNSASKVSTPPTSKESLSTASSPQTTGFTTMATFIPLPNENDNITRADARGQGYAVVTEVPNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HX04</accession>
    <name>A0A1B9HX04_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_06704</name>
        <name evidence="10" type="ORF">I206_101328</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009016.1">
        <property type="nucleotide sequence ID" value="XM_019158403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HX04"/>
    <dbReference type="STRING" id="1296096.A0A1B9HX04"/>
    <dbReference type="GeneID" id="30175073"/>
    <dbReference type="KEGG" id="kpin:30175073"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000001">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF26">
        <property type="entry name" value="GENERAL AMINO ACID PERMEASE AGP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="483"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="60"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCF47797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC67420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="552" mass="60561" checksum="DA8D9FA178248506" modified="2016-11-02" version="1">MSHHIEPEIAPVYALDQLDNDVKSQDKDLTPSSINVLDAEDQHTEPVVQVRLERRLQSRHMQMIAFGGVIGSGFFVALGSGFHSAGPAGLLISFSLVGCLLWIVMQAVGEMSAFMPISGSFMAFSTKFIDESVGFAIGWGYWFLWATLGISEYNTMTILLSYWNTHIPSYGWILLFNVFFLVITTRGVRVFGELELILCTFKIIFIILVMILSIIVAAGGVNNGPVLGFTYWRNPGAFANGFVGVFKTLPLAANFMVGSEMLGTTAGECANPAREVPKAAKQVTWRILFVFILGIFLQGMIVPYDDPQLLNGASPTARAVIAIAMNRNGITGIGHAVTAFCLVANISALNGTMFIASRALANLGFVGHGPKFLTKVSKRGVPVYGVIITNTIGLLALLNTSAGPGQLFTWLVNISGIIAFLAWCTICLCHIRFRAVLRAQNIPLSELPWISKGQPWFSWIGLIASIFFTLISGWTAFYKGFDYISFLQSYIILPVFFGLIVGFKLIRKNPRVDLRAVDLRTGRSVWSPEDFAVSGESRSKRLLRRGRELVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HX10</accession>
    <name>A0A1B9HX10_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_06698</name>
        <name evidence="4" type="ORF">I206_101334</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009010.1">
        <property type="nucleotide sequence ID" value="XM_019158397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HX10"/>
    <dbReference type="STRING" id="1296096.A0A1B9HX10"/>
    <dbReference type="GeneID" id="30175067"/>
    <dbReference type="KEGG" id="kpin:30175067"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050982">
        <property type="entry name" value="Auxin_biosynth/cation_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539:SF68">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="2">
        <location>
            <begin position="190"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF47791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC67426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="644" mass="71022" checksum="A95F667F9A2C7B0D" modified="2016-11-02" version="1">MATYLTLPADLPNHDQGFSPDDDVHHQVHTIAQHWLSQVERAAITNDGELFSSLFVKNGFWRDILAFTNDYRSIRSGNIAKAAKARFPIVKARDFTFASKEPSVEHPFPDVTFVSVHFDFQTETGPAYGIAALVYEDKQWKAFTVFTLLEGVHGHTQKVGANRARGAHNASLSYDEQLEKAREFKDSNPDVLIVGGGHNGLAAAAQLNTLGVSNLVIDTYKRVGDNWRLRYRSLSLHDPVYANHLPFYPFPENWPVFTPAGKLANFLESYVDVLEINVWTQASLDPKQTKFNEKTKRWDVTINRTHISGRQETREFSVGHIVLATGLGGGKPKMPAPFPGQNDWAGRVVHSSKHTSGSDWTGKKALVVGACTSAHDLCVDFAKNGADVTMLQRSPTYVMSVDKGMATLVSGLYGPHGPPTDIADRIAESNPKIIAKLYHKRLIPQLAEQDKELLDGLKKAGFNAWLGPENAGFLMMALEKAGGYYFSTGGSEMIIKGDIKVKQGEIASFDPESQITFKDGSKEQYDVVVFATGYTGFPDTIRATVGEQYAETFNPVWGLDEEGEIRGVSRESNIPNLFFLVGNLSACRLSSKTLALQILAQKEGIFGERYTYAKQKADGDIDDSTIFKAINGVNGHPQVVEDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HX78</accession>
    <name>A0A1B9HX78_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Calnexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_05738</name>
        <name evidence="13" type="ORF">I206_107412</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the calreticulin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894014">
        <property type="protein sequence ID" value="OCF47875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009094.1">
        <property type="nucleotide sequence ID" value="XM_019157454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HX78"/>
    <dbReference type="STRING" id="1296096.A0A1B9HX78"/>
    <dbReference type="GeneID" id="30174107"/>
    <dbReference type="KEGG" id="kpin:30174107"/>
    <dbReference type="OrthoDB" id="1938156at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.250.10:FF:000001">
        <property type="entry name" value="Calnexin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000011">
        <property type="entry name" value="Probable calnexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.250.10">
        <property type="entry name" value="Calreticulin/calnexin, P domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001580">
        <property type="entry name" value="Calret/calnex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018124">
        <property type="entry name" value="Calret/calnex_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009033">
        <property type="entry name" value="Calreticulin/calnexin_P_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073:SF1">
        <property type="entry name" value="CALNEXIN 14D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073">
        <property type="entry name" value="CALRETICULIN AND CALNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00262">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00626">
        <property type="entry name" value="CALRETICULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63887">
        <property type="entry name" value="P-domain of calnexin/calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00803">
        <property type="entry name" value="CALRETICULIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00804">
        <property type="entry name" value="CALRETICULIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008448407" description="Calnexin" evidence="10">
        <location>
            <begin position="24"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="478"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="282"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="515"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="515"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="553"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="129"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601580-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCF47875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC73442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="564" mass="62018" checksum="9F173553A44DFB6E" modified="2016-11-02" version="1">MRAQSVVSAAGTSALMLAASAAAEQAVFHPTSLTAPFVEQFNDAIADSRWTISRATKQTPVGDETFSYVGQWEVEEPEVYPGIPGDKGLVLKTKAAHHAISTLFPEPIDPKGKPLVVQYEVKLQKGLECGGAYIKLLTEGEGGEGFRAGEDYTDKTPFTIMFGPDKCGSTNKVHFIFRHRNPVTGEWEEKHLKNPPAPKITKTTALYTLIVNPDQTFEILINDESVKTGSLLEDFTPAVNPPKEIDDPEDFKPESWIDEAEIDDLEATKPEDWDEDAPLMITDTDATKPDDWLEDEPEYIPDPEAEKPEEWDDEEDGDWVAPLVSNPKCEEAAGCGPWIQPKIKNPNYKGKWTIPRIPNPAYKGVWAPSKIANPAYFEDSHPSDFTKIAGIGIELWTMTEDILFDNIFIGHDASQAKKFADETFHVKKPIEKEAEGSLEDEDLDHPNTLVDKIRLKVYEFIHLATIDFATAIKQMPEVAAGLAAAAFTALGMLLALFGLIGSAPTKVKQTTSVKKTPATTKAVAPVAPAGEEEKKALEDAGVPVPNPEVTNPEVRKRTTRSTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HX82</accession>
    <name>A0A1B9HX82_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_05739</name>
        <name evidence="6" type="ORF">I206_107413</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
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    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
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        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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        </source>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">CBS 10737</strain>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <source>
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    <sequence length="161" mass="17050" checksum="2F016230DBF23703" modified="2016-11-02" version="1">MSSTATPGPSNLRPRNNRPPSLQNIESNHDELSSHRGSPAPSSSSKTQRDDPGSSNTTTSSNVHFPGGLYLPAVKGTIGGIESPRRHMRSAPSISTLRDDSSNPPDSASTIQPRKEGKETTPPPSPPPASRAVFRSDPTIKSCLNGLKMDRAGEIARLFGV</sequence>
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    <accession>A0A1B9HXT8</accession>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
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                <person name="Young S.K."/>
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                <person name="Abouelleil A."/>
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                <person name="Litvintseva A."/>
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                <person name="Zeng Q."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="Yurkov A.M."/>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Litvintseva A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="Mohammad A.W."/>
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                <person name="Yurkov A.M."/>
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    <sequence length="432" mass="46929" checksum="215FF73B9EC78E1B" modified="2016-11-02" version="1">MSQQDNEHNTPSGEESKSRRGSYHDSSRGDEDDDNNETKNRSNDEQKNVNAGNDDKQYENQNGIHKRDDQSKEVKSDQDNQSKDDDFAQSQEGSPSRDDTKQMNESNNVKGQSNEKDKNDSSSTASDNQSSASQNDVTETPPTSTNTNNDENSKDDHSKAESEHENQNIDQSQPENNQTLSHNSQSRHSKYSDREEKLREFEHSKPTDFPENQREEELNRVVNRKPGSRELQQKKQGRLDKPPSSEYDAQKSKKTPQKGDGQQGPLGNVGDLGGVSNQLGDLGGVTDQLGNVGDVGGQIGDQVGQTAGQLGDQVGNVTGQLGNQVGELGKTVGGIGNQLGETTSGLNENVGGISKGLGNTSKQLSNSLNNVGDNALKPLKQKGGLLGGNKDKKDEENEEDEKGALKIRIQLDLDVEVHLSARIKGDITIGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HY29</accession>
    <name>A0A1B9HY29_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_06061</name>
        <name evidence="4" type="ORF">I206_107727</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894014">
        <property type="protein sequence ID" value="OCF48193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009412.1">
        <property type="nucleotide sequence ID" value="XM_019157772.1"/>
    </dbReference>
    <dbReference type="STRING" id="1296096.A0A1B9HY29"/>
    <dbReference type="GeneID" id="30174430"/>
    <dbReference type="KEGG" id="kpin:30174430"/>
    <dbReference type="OrthoDB" id="2565132at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867">
        <property type="entry name" value="RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="73"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="276"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="458"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="598"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="730"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1144"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="623"/>
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        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
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            <begin position="789"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="867"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="285"/>
            <end position="355"/>
        </location>
    </feature>
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        <location>
            <begin position="469"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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        </location>
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        </location>
    </feature>
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            <begin position="1279"/>
            <end position="1292"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF48193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC73755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1431" mass="159862" checksum="2A6611AE7388B9A0" modified="2016-11-02" version="1">MPNWVTDNSTSNTNQNQNLETDMANSSSLPTSNVAAPPHLIVDKAGPSVTLSTSMDKAEALKSNEHSVAQGLIESSKDSPIILSPDTPPESAVPQMPTALPVPDQPQNAAHTLTSLNNPNDHTSQQPANGPLPINQPVPMRSVSTSILPNGTQPYSNPSSIINSSVINESPAVPTNQLAVGSIAVSNPTTPATRLSPAIPYSFQSRDRSTVTFSIAPEYAQRTFCFTKDNHFRELTTLDILTLSASALTATDLERAIKKPSYLIELGKSLVDGYFKRSSSRHEQQQQPSTRTHQSSQNRQIQAGPSRPTSSVSSNGYSYNPQHNPLQTHHSIESVQQQQNRSRPASRQSVTSISRMNPEATPLHSPGVDSPKTIQPPEVRAIQQEFVRDLQGVEQMFGLAWERLKTASESAFDKMGNTYGNFSRSTEQLEHLKSQLAEGEKKLISSQTTVLRLTESETAARTELQNTKRKLEEEIEGRKREQGPDGPRQKVIADLQKVIADHKRLQAELQELQKTLNAETAEKNKAQAINRSLGAQLGQCATELQRVKTQQAADFSLLTAKNEKILSLEKEHGAKINQLTNKYFSEVDKLKKEIAETSRPIFGAHSTNSPKTPKSPADPAAESAKLRSLLKAKNEKFAELQERHDEELTELKTRLGKDPKEWEKEIKEKLNAQHSSAIGRLEKKVNELQAEKSQAVAIPPTPVPDEQIVLALTKILNWCESLQKSLVRSTTNNIDDPSSATSSPVLPSLAPPFDHGTNNETSQSRALLDRANDFIRDMKNTAATMLSRNKDREEKVKKLQGQVELLKVQLNAAQSDLPALRDPGTAEETNDLKVAFGKIIAWGENIQTLMGKTIEQPQTDIKPLERADKFQREMHEVFEEMQIKNKEQKQSAGSDDKQIKELEDKLQEKEKYLQANLQALLAKSTQYDETVNELTLTSRFLESVKSSLKETENELKDTEQALEEAQTGLKDVKARLGEAEKEIKAKEEEIKKKDDELKIKGEELKNKEKELIQMAEDLKNMEERLRKKEEELQEKDKYWQTMLEEARTEAVLDVDIGGKESAKQLAEMLEAKDKLMKEMNGLQMDNKKLLVQIEEQQEKIDQLQKDMENEQNNVDTAEEALREAMDRQFKQREEYVESEIQLKEAKDQRNKLKEQVQKLQEELKLSKKSVPPNTPGMSGQKIEPTQIGNAVLDTASENRKQMDQSASTNGNGKRPISRLYSSSPKISASRSSSPDIQIMASKQSQTPSQPPPTSSQHPPRNLSNTPLFLPNDEDDDRSFSQTPVTPGVSVSVQRPKKKKRVIDDSDDAPPDQGTPAPVVSISQAPSITHSRAGSVQPTHSFEPVSKEWLKKNINLCIHKKDDRVRCKLCFVNEKKAAGSKGLSMKVEQIKPLPLGMTDSEMFEHFYSHGETLRRLKDKRIREGKERASPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HYN8</accession>
    <name>A0A1B9HYN8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_05151</name>
        <name evidence="5" type="ORF">I206_107305</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC73338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009593.1">
        <property type="nucleotide sequence ID" value="XM_019156875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HYN8"/>
    <dbReference type="STRING" id="1296096.A0A1B9HYN8"/>
    <dbReference type="GeneID" id="30173520"/>
    <dbReference type="KEGG" id="kpin:30173520"/>
    <dbReference type="OrthoDB" id="1621678at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000004">
        <property type="entry name" value="5-keto-4-deoxy-D-glucarate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050251">
        <property type="entry name" value="HpcH-HpaI_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502">
        <property type="entry name" value="2-KETO-3-DEOXY-L-RHAMNONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502:SF9">
        <property type="entry name" value="HPCH_HPAI ALDOLASE_CITRATE LYASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="3">
        <location>
            <begin position="36"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF48374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC73338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="272" mass="29158" checksum="2EEDFBD37DB911AD" modified="2016-11-02" version="1">MVSDGSTSYPTAHTTTIQNPRLRLLNALKKDEKPMMTFMAIPSVRHAQIVALTGLDGIIIDCEHGHIGDDAMHQSVAAISALGVSPIIRIRGPLPDIIKRALDTGAHGIMVPQINTAEEAEAVVRYSKFPPQGLRGQGSAFPAIGHGLTTPEYMQSANQTILTMVQIETAEGLKNVDAIAAVPGVDVVFIGPNDLAQSILGYVPAKGDEPEFTKALEDIVAAARKHGKWVARLSNNGELAKEHKKTFDSLAITGDTKAIQNWYIAELEVARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HYR3</accession>
    <name>A0A1B9HYR3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Epoxide hydrolase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_05177</name>
        <name evidence="6" type="ORF">I206_107278</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC73311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009619.1">
        <property type="nucleotide sequence ID" value="XM_019156901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HYR3"/>
    <dbReference type="STRING" id="1296096.A0A1B9HYR3"/>
    <dbReference type="GeneID" id="30173546"/>
    <dbReference type="KEGG" id="kpin:30173546"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF39">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="4">
        <location>
            <begin position="15"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF48400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC73311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="399" mass="46121" checksum="898C2D3F7E538554" modified="2016-11-02" version="1">MSYSKPPFEPTIPLESFKISIPDKDIEELKTLIKLTRIPKETYENIDSEKKDFGISRKWLIETKDYWLNQYDWRKNENRINAQPAFITKIKNKDGLEYKIHFAALFSKNKDAIPIILSHGWPGAFIEFLGLMEYLRERYTPEELPYHLIFPSTPGYLFSSSPPLDREFSVRDVGYLYDQLMKGLGFSEKGYIAQGGDVGSHITNELGRSHSACKAIHLNMRVFLQPPKGTPENESQPFGIPEFLNKLQKYGYNLEHATRTSTVGLAIGSNPISLLCWIGEKFLEWSDESPSLEIILNFINLYWFTDTYPSCIFTYRYGFGSKRDENSAEKEFNNKPTGYSYFPKEITPVPPHWVKTAHNLVWTREHKSGGHFAALEGPETLWEDVEDFVKQVWPEVSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HZF5</accession>
    <name>A0A1B9HZF5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Neurofibromin 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_05424</name>
        <name evidence="6" type="ORF">I206_107033</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC73068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009863.1">
        <property type="nucleotide sequence ID" value="XM_019157145.1"/>
    </dbReference>
    <dbReference type="STRING" id="1296096.A0A1B9HZF5"/>
    <dbReference type="GeneID" id="30173793"/>
    <dbReference type="KEGG" id="kpin:30173793"/>
    <dbReference type="OrthoDB" id="28245at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF142">
        <property type="entry name" value="NEUROFIBROMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="4">
        <location>
            <begin position="1320"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF48644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC73068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="2721" mass="299119" checksum="254780F7EF5616CE" modified="2016-11-02" version="1">MPVRRNGSSPHHSFSSPTALFRSANSSSSQSQSNHHNYARGESSMNQASSSARDNNSIDDTGSIIMRPENYSPEQKVINSLVSRIVNKLPCNSGIRLAIMEVDPGVQATIGSLLQLSKSRVSLIVQSLMGALETLSKYTSSSSMVESSLDVLHSQLYLLHILNLCLSTSWQVSSQQSPPPQDVLPRCWPDPYPFDEALARYTLGVILIYARLVFNDAANDERTSPAPTKESRTSASSSTTSSVRSVISNNSSYTLGTKFIQEHSYHSSPSTPSTSSTKAKLLSTSCITPATVITQISKYISRVIFYISASNWNLIMSKLKIRIGHLQTTIEESPDVIEMRLIEWSNLDRNRLSQVVQEINSGFIHVKRPAQLAIANSLRKAIWNWIEVHPIEYESFILANKKMEGGVESLWETLWSLSDSGFTSSNTRRTKSFYPLLAMLMVLTPDIFTKMVATETTHRTSPLNQAAFIDRVRKGLSSSKSIETCAMVHVDMVKIAMALSPEHRASGVRSLVPDIQSDIKHALFGSSNSSEVSDSNILIDGLVALYRSDPGTISSALFPKLLTSPVEFNKLAAVRACVVIAVQGQRLPWFAPVNDLRGVVGPSLRAILRNYAQSLSSRRRALPELPSNQTDLINEILLLYSLDPEFVFTGCSSDQSASSNDSLHQILLALSDLTVTPSPDSLSPIASRTACILIDDMRRKSLGNKEFERLATSAGGAIWQILLDVGRQTLFAFHDADSDVVATSMNALRASSSAVLRLAEEFPTILFPSSMAQPAAMVISVAGFTTCAGPDSEQISLTLPMLSVLGQLTRKAHMSAIGQLTPTTNGLIPDKRANAFDALAMLPTSIGRQQQQRQIRRTLRPLAIPTPFTIGLWIGLATVAQKLTTKIIAADADATMSTRDVRRRAMTADIDGLDEEESKEWQNLISWLCACVNAANYETKPPPSLCDIIGKGILPPAYDQHISDPHVPVELFVKQCVDLLVSASVNVRETVKNALGSELPTNGCRMLVGPMIKLLSHAISPSGVNISEPFTIFVEQAVSVLRLLIDRMGPGDDVPSVQVDLGDLLYLLAQYIHRLGRSDNALRLKSRFCHLIEVALKKPENVSTSSSINFKNAFLDWMSEWSLESMRDNDVYVSGVTTTSKYQRELDHACLQAMVPVTEGLVLKIPGEEGDNSQGVVKPRLFYKHYHHLVKILERSSFEEAESVGHNSSIHGNGNGITKDSPTHDTHTLAILALSNLLSANVDVGLKHCLTLGYHEDPILRTAFMQLMTNTLQRGTRFGGLSSKHQRNPESINQYLDLLAGPNLALALAMVDVCPQSGNEVDELSTLLFRVFEGKGALLGLMRALIEREVALTNHESELFRANSITMRMLTIFAKTYGYNYVRMTLQPLVLSLIEKPAECSFELDPSKASGTDDIDRNADHLRLMCQALLDLICSSTPRVPLMFRAMCHHIWELVDDRFPDSRHSAVGSFIFLRFFCPAIVSPESIDLDVNPDTRETRRALLLITKVIQNLANNVVFKELHMKVLNSFLSDNIRQVTKFLSDIAIRPKTADIQNATKGFADDAERYQDLDGDDAIIHRFVYKHKSKIETSLANMPMHFRNTAVVTKIARTELDGKAALEHLTKIMDKSGPPPANNGLSASARSQVYDEFMQHHLGRNTDSIADAFYEGPASQNGRRIFYFIVSRVALVDYDLLAYHVFSILDKVTDFFDIVIDLTNFSAANELPLPWLKRSIQLFPPGVLPSVHTLALYNPNTYAKKRIRRFVSELLTITPTIGKTVIACSSPSELADSIPFTSLALPEYTMALAYEADHVFTNLLCVSDHEMQVPVIVKQGHDSLQIASWKKQEILSGIKSYVIDIVPLHDIDDIIVGNSSPSDHLVIKYGQGETLTFVSRRRNEMAQIIRAARARLREGPTNERALRPSDVPATLLNVALLNLSSSDGTLRMGAYILLNELCQFFKYDLASKVLHVSAGLSIPNNSLAFVGNLSKALAASVPHLTVEFLKEWTIGFGKADTPLKTACLYYVGPWLANLDQFSRPTKEDGLDSIKQVREIIRAFIGITVAERRRLHLAIQEQIWAILTQSHESLADLVVIELIHAAIDAGIGSDKAECVGDILVSVSSTAVRGKVIAKLRKTLAQTYLKPSGHITENAAWPEICSLSRITLILGFNPTSSLDTQLFLPEIFHIITLLLGSGPVLMRQTIFGLLVNVVQSLASSPTSGDMEALALLNLLKRVQQPQIMAAFGLAQGQGSIELSGLPMKDETDLQLLERVEEVSKFLGEVLAGGAISMDCANAWRARWMGLVAATCFQHNPATQPQAFTVLGYLASDEVDDDLVYQILVAMSTTLSHFQEGDSVLLISMLRCLSRIIKGLLPDSRYASNLFWLAVSILQLGYIPLFAPALELMNASLVAVSETTTPHQILRGKDLMDFLLDTRRSITEQAKKLDQVSGVSFETDLTFALVAVIYKGVRHPTTKKLTIDSLMALLSLSAEPARPNGEDEMMVSPGSIAYFIALLSTGNDEIKHIFQCAGLDIDPREEMANVAIFDMLSIPDNSTALLLISLVVALLSGSGGSDGEKVVLYRLLADASTEIPEVVAMTYDVIIPKIITTLTTTSNLSILKSTSIILEIALSNSSYSLPNLSHTDSSTSLNLHNQQHHHHHHQKVYSASISSNPSLGASGTGSREQVLDDLGFKGLNELGFIQIKYDKLSMMTKWIAGLIEGFTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HZU9</accession>
    <name>A0A1B9HZU9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_05532</name>
        <name evidence="3" type="ORF">I206_106924</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC72960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009970.1">
        <property type="nucleotide sequence ID" value="XM_019157252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HZU9"/>
    <dbReference type="GeneID" id="30173901"/>
    <dbReference type="KEGG" id="kpin:30173901"/>
    <dbReference type="OrthoDB" id="2579428at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="3"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF48751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC72960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="94" mass="10789" checksum="9EF68D4AD7509EA7" modified="2016-11-02" version="1">MSFVKYVAFIAKEGKRQELLDLVLEIRDVVLANEPGTKLFHVVVDPENGEIITWQHYENEQALEDRHNGKTHAIWVEKKGDLVGSFVSRKLPFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I0A4</accession>
    <name>A0A1B9I0A4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methylthioribose-1-phosphate isomerase</fullName>
            <shortName evidence="6">M1Pi</shortName>
            <shortName evidence="6">MTR-1-P isomerase</shortName>
            <ecNumber evidence="6">5.3.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">S-methyl-5-thioribose-1-phosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MRI1</name>
        <name evidence="7" type="ORF">I206_04656</name>
        <name evidence="8" type="ORF">I206_105836</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-(methylsulfanyl)-alpha-D-ribose 1-phosphate = 5-(methylsulfanyl)-D-ribulose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19989"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="EC" id="5.3.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.23" evidence="6"/>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF48969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC71877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010188.1">
        <property type="nucleotide sequence ID" value="XM_019156386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I0A4"/>
    <dbReference type="STRING" id="1296096.A0A1B9I0A4"/>
    <dbReference type="GeneID" id="30173025"/>
    <dbReference type="KEGG" id="kpin:30173025"/>
    <dbReference type="OrthoDB" id="2461at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.420:FF:000003">
        <property type="entry name" value="Methylthioribose-1-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10470:FF:000013">
        <property type="entry name" value="Methylthioribose-1-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="entry name" value="translation initiation factor eif-2b, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01678">
        <property type="entry name" value="Salvage_MtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005251">
        <property type="entry name" value="IF-M1Pi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011559">
        <property type="entry name" value="Initiation_fac_2B_a/b/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00524">
        <property type="entry name" value="eIF-2B_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004326">
        <property type="entry name" value="PRK05720.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00512">
        <property type="entry name" value="salvage_mtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475:SF1">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCF48969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC71877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="390" mass="42626" checksum="84F32903CB6153F0" modified="2016-11-02" version="1">MVAQAPSGKKPLPDMMTSIRIDKSGQVEIVDQLLLPHSVKWIPISTTEEAFEAIKSMKIRGAPAIASLAALSLKSSLSSSFNINGKSKEEIKNWILEKCNYLQSSRPTAVNLSEAMNRIRNYIKASTNSKSNTTELIEKVKEICKNVHEEDLERNMLMGKLGAEWLFKKSGEKQKLKVITVCNTGSLATSGYGTAIGVITALFENEQLDTAYYAQTTPYHQGSRLTSLELTTLQIPACMICDTMLGSLFQHEDIDGVIVGADRVVKNGDTANKIGTYQAAVLAQRHNVPFMVVAPVTTIDLSLQTGAEIHIEQRPSIEATQIRGLNLETGKLSVIRITPEGVGEGDKPWQKVYNPSFDVTPAELISCVVTEKGVAERKQGEKSINVSSIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I0A6</accession>
    <name>A0A1B9I0A6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_04663</name>
        <name evidence="3" type="ORF">I206_105843</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF48976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC71884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010195.1">
        <property type="nucleotide sequence ID" value="XM_019156393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I0A6"/>
    <dbReference type="GeneID" id="30173032"/>
    <dbReference type="KEGG" id="kpin:30173032"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF48976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC71884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="124" mass="13633" checksum="61D2E58D1D2BDF64" modified="2016-11-02" version="1">MARGHADPDADPDADPDADPDKRSFTIDSALCIPLSEDSKDPKIVQKNTEKLNDTLSNRSWLVARDKNGNDLYSLSPSQQVLDSALPNYEVDYDFKKSVDALSTTPGTISGLIFFRQQSAVDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I0E6</accession>
    <name>A0A1B9I0E6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_04700</name>
        <name evidence="6" type="ORF">I206_105880</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
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                <person name="David-Palma M."/>
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                <person name="Bowers K."/>
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                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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                <person name="Heitman J."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="Gargeya S."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I1P5</accession>
    <name>A0A1B9I1P5_9TREE</name>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49452.1"/>
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        </location>
    </feature>
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        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF49452.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC70495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="283" mass="31903" checksum="2839C5E144F99A3E" modified="2016-11-02" version="1">MDAHITLSDTHDSTYSESTQYGKSLINNSVFELLETYNHDRARLESKRSIHDTGLTNELSNAITTNRKGKKKSGDLPDKRAGASRLDGPQTVYGVGSFHKQFSAESSASSAGPPLNYFEEVPSQQTYAPAIGSSSGYGMNPIRSQPFGYSDNNSSPQSAGVRPLDQYDTKPTVMNYMDITPGRNYAETYGYCDTETQNWLEALSDGMAHFDSETLSRLRNDEPVFRQNISSILNERSTIFAEVYYTDWEGKGKVLAQQIIERAITRRYEIDQQYHQQRQQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I242</accession>
    <name>A0A1B9I242_9TREE</name>
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        <submittedName>
            <fullName evidence="10">Hydroxyacid-oxoacid transhydrogenase</fullName>
        </submittedName>
    </protein>
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        <name evidence="10" type="ORF">I206_04134</name>
        <name evidence="11" type="ORF">I206_104289</name>
    </gene>
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        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
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            <dbReference type="Rhea" id="RHEA:23048"/>
            <dbReference type="ChEBI" id="CHEBI:11047"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="EC" id="1.1.99.24"/>
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    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>4-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + succinate semialdehyde</text>
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            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16724"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="EC" id="1.1.99.24"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="OCF49612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="WWC70339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010831.1">
        <property type="nucleotide sequence ID" value="XM_019155873.1"/>
    </dbReference>
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    <dbReference type="STRING" id="1296096.A0A1B9I242"/>
    <dbReference type="GeneID" id="30172503"/>
    <dbReference type="KEGG" id="kpin:30172503"/>
    <dbReference type="OrthoDB" id="339764at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047988">
        <property type="term" value="F:hydroxyacid-oxoacid transhydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08190">
        <property type="entry name" value="HOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000003">
        <property type="entry name" value="Alcohol dehydrogenase, iron-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1090.10:FF:000003">
        <property type="entry name" value="Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042157">
        <property type="entry name" value="HOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF83">
        <property type="entry name" value="HYDROXYACID-OXOACID TRANSHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="8">
        <location>
            <begin position="101"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="9">
        <location>
            <begin position="303"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF49612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC70339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="513" mass="55555" checksum="7C4390EDD65114BB" modified="2016-11-02" version="1">MPPPVSRASVIRLLNLTSNQGCRGCGRTHSALDHHTHGHGHVGVRGMATPIERNTGGPPPGNTDYAFEMAASTLRFGPHATREVGMDLSNMIKQLPASDRSQAKIGIFTDPNVVKLPVMEVVEESLMREGLNWVVWDNCSVEPTDKSWQEAINFARSSNITHFLAVGGGSSMDTAKAANLFVNYPEADLYEFINAPIGRGKPIEKKLSPLIAIPTTAGTGSETTGTAILDIPSRQFKTGIASRALKPTLGIVDLNNTATCPKEVAIAAGLDVLFHSLESWTAVPYYERTPRPANPINRPAYQGSNPISDIFSRWALETTIKYLPRIAKDPFGDEEARAQMLLAASTAGIGFGNAGVHMCHAFSYPISSLNKGRPQNLQYHHPSYSPKIPLIPHGVAVSLTAPAVFNFTATSSPTRHREALGVFLGKDRAHELNNVKDADIGTALSEEIKKFLDLVEVPRGLEKVGYTSGDIAKLVEGCLPQRRVLDLAPLLAKDDLALEKEQLAGIVERSLKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I2N9</accession>
    <name>A0A1B9I2N9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Alternative oxidase</fullName>
            <ecNumber evidence="16">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">I206_04235</name>
        <name evidence="19" type="ORF">I206_104190</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes cyanide-resistant oxygen consumption. May increase respiration when the cytochrome respiratory pathway is restricted, or in response to low temperatures.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="16">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the alternative oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="16"/>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010930.1">
        <property type="nucleotide sequence ID" value="XM_019155972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I2N9"/>
    <dbReference type="STRING" id="1296096.A0A1B9I2N9"/>
    <dbReference type="GeneID" id="30172604"/>
    <dbReference type="KEGG" id="kpin:30172604"/>
    <dbReference type="OrthoDB" id="16906at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098803">
        <property type="term" value="C:respiratory chain complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009916">
        <property type="term" value="F:alternative oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010230">
        <property type="term" value="P:alternative respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01053">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.140:FF:000002">
        <property type="entry name" value="Alternative oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.140">
        <property type="entry name" value="Alternative oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002680">
        <property type="entry name" value="AOX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038659">
        <property type="entry name" value="AOX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803:SF3">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01786">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12 16" id="KW-0408">Iron</keyword>
    <keyword evidence="14 16 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 16" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OCF49711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="WWC70240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="405" mass="45996" checksum="F0FB75B28A292C48" modified="2016-11-02" version="1">MSTIAIRSTTLAKSTLLSRGPMICQAYHFQHLPIASSSRSFSVSSRARLQVDEPKQASLALRTDIKEKEERSSQKIVGGTGKGVEGPHYQDQVHQTQDILTNESTTGAWTMMNPIYTEQELDTVKVVGRVPVTVADKAAHRTVKFLRKAFDFLTQYKAIPISQEVLKQNPIPIEELRSKGLLLSHHKWLFRFILLESIAGVPGMVGGTLRHLRSMRLLRRDGGWIHTLLEEAENERMHLLTFMTMAQPTLFTRALVLGAQGVFYNAFFLTYLFSPKTAHRFVGALEEEAVRTYTHCIEDLENNLIPEWNDVAAPRIAIDYWRLPQDAKLLDVIRAVRADEATHRFVNHSLANLDQQKDFNPFALVEADAQTRGEKWGFTREESANFAREQQQKLQDVSTKQIADQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I2R7</accession>
    <name>A0A1B9I2R7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Translation initiation factor 4G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_04363</name>
        <name evidence="11" type="ORF">I206_104061</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
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        <text evidence="2">Belongs to the eukaryotic initiation factor 4G family.</text>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I396</accession>
    <name>A0A1B9I396_9TREE</name>
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            <fullName evidence="1">Cupin type-1 domain-containing protein</fullName>
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        <name evidence="3" type="ORF">I206_103912</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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    </feature>
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        <source>
            <dbReference type="Pfam" id="PF00190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF49984.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC69968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="280" mass="32010" checksum="2B1E4414384EBE55" modified="2016-11-02" version="1">MTENIQHNPNFKIETYNIPPTDLIPNSGWPLIVYREYYNFEDEDLSIKFFDLLLKNEWQPKWIYQYGNSQRSHYHPTSHEVMLVLSGEAKIKFGSGDLTSNINESLKKGKFELGGIILNAKKGDIFLLPAGLSHKTFNTKPLNSFKLLTPNGTKTMTLESKKKLKEIKEINKEKGFIMMGGYPFNFLPGKFSVGGEGALEFSKVWSIPKPNFDPILGNSILGLNYLWKGNNAFPITNTKINNENENETLPKDKLDYLIPFPEINSWRADLVNIDSLEEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I3D6</accession>
    <name>A0A1B9I3D6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glucose and ribitol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_03358</name>
        <name evidence="5" type="ORF">I206_105738</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC71779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011261.1">
        <property type="nucleotide sequence ID" value="XM_019155107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I3D6"/>
    <dbReference type="STRING" id="1296096.A0A1B9I3D6"/>
    <dbReference type="GeneID" id="30171727"/>
    <dbReference type="KEGG" id="kpin:30171727"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF26">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_4G05870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
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        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF50042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC71779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I3U1</accession>
    <name>A0A1B9I3U1_9TREE</name>
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        <recommendedName>
            <fullName evidence="11">Guanine nucleotide-binding protein alpha-2 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I206_03460</name>
        <name evidence="16" type="ORF">I206_105640</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the G-alpha family. G(q) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011360.1">
        <property type="nucleotide sequence ID" value="XM_019155206.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A1B9I3U1"/>
    <dbReference type="STRING" id="1296096.A0A1B9I3U1"/>
    <dbReference type="GeneID" id="30171829"/>
    <dbReference type="KEGG" id="kpin:30171829"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
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        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:Rho protein signal transduction"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000009">
        <property type="entry name" value="Guanine nucleotide-binding protein G(O) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000051">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Gprotein_alpha_12/13"/>
    </dbReference>
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        <property type="entry name" value="Gprotein_alpha_su"/>
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    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF242">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-1 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00440">
        <property type="entry name" value="GPROTEINA12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="176"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="201"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="270"/>
            <end position="273"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00074402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCF50141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="WWC71682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="357" mass="40862" checksum="D8903ACD8277FD7A" modified="2016-11-02" version="1">MGVCMSTPSEDPEADKRSKEIDRQLKEDEKKLAKEIKLLLLGAGASGKSTILKQMRLIHNKPFEPVEIEDYRKLTFSNIVGGMRTIIDVMDELNLAVLPENRKYISLVDSEPPINTGEVYPIKYLNALNSLWADPNVQECYRRGNEFALAENMPYFYADLNRLFKSDYRPTSDDILRVRSKTTGISETRFPLNDVVFRLFDVGGQRSERRKWASCFENVTAILFLVSLSDYNSCLIEDRESNGMQEALLLFDSICNSQWFIKTSIILFLNKADLLMEKIKDPQQQIKKHFADYEGKPGSFNDAVEFFKGKFRSCNRTPSKEIYCHVTTAVDVQNVKIVMAACQDTILKNALRDMAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I416</accession>
    <name>A0A1B9I416_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Adenylyl-sulfate kinase</fullName>
            <ecNumber evidence="4 11">2.7.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I206_03584</name>
        <name evidence="14" type="ORF">I206_105513</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the synthesis of activated sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the APS kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.25" evidence="4 11"/>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011484.1">
        <property type="nucleotide sequence ID" value="XM_019155330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I416"/>
    <dbReference type="STRING" id="1296096.A0A1B9I416"/>
    <dbReference type="GeneID" id="30171953"/>
    <dbReference type="KEGG" id="kpin:30171953"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000212">
        <property type="entry name" value="Adenylyl-sulfate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00065">
        <property type="entry name" value="Adenylyl_sulf_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059117">
        <property type="entry name" value="APS_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003013">
        <property type="entry name" value="PRK03846.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055">
        <property type="entry name" value="BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055:SF1">
        <property type="entry name" value="PAPS SYNTHETASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01583">
        <property type="entry name" value="APS_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004347"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCF50265.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC71555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="203" mass="22337" checksum="C9D595C0E7289C04" modified="2016-11-02" version="1">MATNITFHPGAVTEDERNSLLSQKGATIWLTGLSASGKSTIATALEQHLLHKKLHAYRLDGDNIRFGLNKDLGFDQASRVENIRRIGEVSLLFSLSSTIAITAFISPYISDRELARSLHEKHSSGIPFIEVYVDAPLDVVESRDPKGLYKKARAGEIKDFTGISAPYEAPAKPEIHIRTDQVDVAGAVEIIVKYLEEKNLIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I4A2</accession>
    <name>A0A1B9I4A2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_03675</name>
        <name evidence="3" type="ORF">I206_105419</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
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    </reference>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC71462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="kpin:30172044"/>
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    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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            <begin position="390"/>
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        </location>
    </feature>
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            <begin position="406"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="WWC71462.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1B9I4F9_9TREE</name>
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    </gene>
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        <lineage>
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            <taxon>Basidiomycota</taxon>
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    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011618.1">
        <property type="nucleotide sequence ID" value="XM_019155464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I4F9"/>
    <dbReference type="GeneID" id="30172089"/>
    <dbReference type="KEGG" id="kpin:30172089"/>
    <dbReference type="OrthoDB" id="10565892at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCF50399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC71415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="438" mass="50337" checksum="EAFC588FA2049124" modified="2016-11-02" version="1">MLPIRSHPNSDRESSLNDTKVDCHATYGEDTTRIDDLKRTLFLTFSGISRKSYSDLWKKGFVNEKDLARREDVTLTLKRMLDDEEKRSEVDIERGGRVAKFVRSLFTYSDQKTIGRLESLQATILRNVKLSETRFRENHEQILNVMYNGWIKTRKYDKATLQIADCPTQSIIESMSEDLLDVTEDFAREIMVNKILKAIEANDGNSLSEVYLRDMSLPETVIKDWTSTRSYTDQKLDFEDNGLQRQHKCTLESDQTDCNNEKWTRPFHMLNFPFRRNSSVQKLLMEQEKRSLWPLEFGKSVLERLGSEVPSALKKASQEGDSDLKKLISASDIDRIVSHMSGDILLQNKLEDLLKPTLKERESSGRTGQGTMTDLSIMVEPFKNSQGELDFTLCWSNEDQGAGYFFDAINLPNSSTRRIHPDCSDYSSLSALLKDGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I4I0</accession>
    <name>A0A1B9I4I0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Exportin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_03753</name>
        <name evidence="9" type="ORF">I206_105337</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011650.1">
        <property type="nucleotide sequence ID" value="XM_019155496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I4I0"/>
    <dbReference type="STRING" id="1296096.A0A1B9I4I0"/>
    <dbReference type="GeneID" id="30172122"/>
    <dbReference type="KEGG" id="kpin:30172122"/>
    <dbReference type="OrthoDB" id="27218at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000022">
        <property type="entry name" value="protein EXPORTIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041123">
        <property type="entry name" value="CRM1_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041235">
        <property type="entry name" value="Exp1_repeat_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014877">
        <property type="entry name" value="XPO1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040485">
        <property type="entry name" value="XPO1_repeat_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF2">
        <property type="entry name" value="EXPORTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08767">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18777">
        <property type="entry name" value="CRM1_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18784">
        <property type="entry name" value="CRM1_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18787">
        <property type="entry name" value="CRM1_repeat_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01102">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="7">
        <location>
            <begin position="34"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1049"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1049"/>
            <end position="1062"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF50431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC71382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1080" mass="122225" checksum="E48AFE08C575EA78" modified="2016-11-02" version="1">MEAILDFSQDLDVGTLDQVVQAFYTSAGEQQQQAQKVLTQFQDHPDSWQRVPAILETSSSINTKYIALQILEKLVQTRWKALPADQQTGIRNFIVQATVEVSSDESRMRREKGYLNKLNLVLVQILKQAWPKDWPQFIPEICASSRTNLSLCENNMIILRLLSEEVFDFSAEQMTQAKTKALKQTMCSEFGEIFNLCNEVLEKANKPSLIKSTLETLLRFLNWIPLGYIFETQIIDYLVSRFLEQAEFRNVTLKCLSEIGALNVGPEYNSKFVTLFQVVMTSINRMVPPNTNMAAAYVSSDDEDQQLIKNLALFLTNFLHTHLRLIETPDNTELLINAHLYLIKISTVDDREVFKICLEYWAKLVAELYEEIQSLPMSDINPLMNLNIGGLGAGLNGPHSMGLNGMPLRKNVYSDILSNLRLVMIEKMVKPEEVLIVENDEGEIVREFMKESDTIVLYKSMREVLVYLTHLDVQDTETIMTDKLSKQIDGTEWSWNNLNTLCWAIGSISGAMNEETEKRFLVTVIKDLLGLTEMKRGKDNKAVCASDIMYIVGQYPRFLKAHWKFLKTVVNKLFEFMHETHEGVQDMACDTFIKIAQKCRRHFVMQQAGEQEPFIDEILRTLHRITVDLSPQQVHTFYEAVGYMIASQPNKPTQERLIEKLMELPNNAWDNLMQQAASNVDVLGNPENVKILSNILKTNVSACTSIGSFFLPQLGRIWLDMLGLYRTVSGIISDQVQQQGVIATKTPKVRSLRTIKKEILRLVETYVKKAEDLEGINTNLIPGLFDAILGDYNNNVPTARDAEVLNVTATIVSKLGNILNPQIAPILDAVFEPTLGMINQDFSEYPEHRVGFFKLLRAINLTCFPALLEIPPHQFKLVMDSVVWAFKHTMRDIADTGLNIAYEIANNFAASSPEIANQFYQQYLLTSIGDVFYVLTDADHKSGLKMQGILLARLISLVETGLVQAPLFDPAQVSDPSMSNATFLKGYISDLLANAFGHVQPAQISSFVNLMFENSSDPIKFKLTIRDFLISLKEFSGDNAELYIDEKEAEAEKKAAEEREAASRVPGMLKPAQLDDDADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I4J4</accession>
    <name>A0A1B9I4J4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNAJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_03762</name>
        <name evidence="4" type="ORF">I206_105328</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
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                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
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                <person name="Imamovic A."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Heitman J."/>
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</entry>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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                <person name="Birren B."/>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <source>
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    </evidence>
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</entry>
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    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
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                <person name="Young S.K."/>
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                <person name="Dewar J."/>
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                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
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                <person name="Imamovic A."/>
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                <person name="McCowan C."/>
                <person name="Murphy C."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">CBS 10737</strain>
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    <reference evidence="13" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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        <text evidence="8">Belongs to the activator 1 small subunits family. CTF18 subfamily.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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            <end position="453"/>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="881" mass="98596" checksum="B817FD2D5DB946A0" modified="2016-11-02" version="1">MSESTTIKPLFEPTDIFNFDFPTPPLSNQSTSETSKDASTNLESELEITRDMEIRSRSERMILDSPPPPDYEEEPDFDEDELAMMELERETITLTKKTTSIQSNPFIVDKSKGKDQPEEFVSSGIFEESETDQPIASSSRLALTPPPESDLTPLPIFQNHFNTCTLPSLRAETMQGKIITFKRRNKPKPSNIQLHSKNAKVNVGDLLSVPLHKLLAEVDELKSQQEAIKLQQKYDEERRRAERASMTAIKRSTVMWVDKYRPKQFTDLLGEDRVHRDVMNWLKEWDKCVFKRVQPGKKRKLDDENFIVDPLGRPRERILLLSGPPGYGKTTLAHIVARHAGYKTLEINASDDRLAATVSTRIKNAIDAGSGLASDGKPTCVVIDEIDGASGGGDMSFIRSLLKLIQDVPARKKSNTPARPLRRPIICICNDLYASSLRPLRPFARVIRFKKPQSQILVKRLREICDRETLSADLRVLTTLVDVTSGDVRSCLNTLQFIKSKSSAVTDEAIRSSSVGMKDSGTSLQNVWNTIFIPLAAKQKRKAIGIDNGRYVDRLSFTIQASGEYDKVVQGLFEHYPNVKPLDASLGNLCKVHDWLGYYDHLSTRVSESQEWDLMGYMPYAITAWYHHLAAPANNSKPTEWPKADYEAYQARIANEEISTSLKNLVPPILRSLFSTSTLLTEFIPLIMRIISPPLKPVNANIVKAGERAILDRLVDLMIPLGLRFWQEKGENGQPMMRLEPPIDVFVHYEGKRADDIAASRFAVRQLVAQAIEAEIARRKGAGVEGDGTTGSDGFAKAYGLKGNAGLGKRTVDKAELPATDFFGRTKSINIPLLGTESPTEESVSTNLPIEPPIKKFKAIYKFNEGSSSAVRKSIKMSTLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I5F1</accession>
    <name>A0A1B9I5F1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_02805</name>
        <name evidence="3" type="ORF">I206_102455</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF50749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011968.1">
        <property type="nucleotide sequence ID" value="XM_019154565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I5F1"/>
    <dbReference type="GeneID" id="30171174"/>
    <dbReference type="KEGG" id="kpin:30171174"/>
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    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
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        <location>
            <begin position="60"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="187"/>
            <end position="223"/>
        </location>
    </feature>
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            <begin position="279"/>
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        </location>
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        <location>
            <begin position="656"/>
            <end position="696"/>
        </location>
    </feature>
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        <location>
            <begin position="65"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="349"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="417"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="677"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF50749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC68526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="809" mass="90828" checksum="537A91C141A7FAA4" modified="2016-11-02" version="1">MNDDGWDDGFHSESYESPDEDEVFDRHALSGNADLVKELDLASRWEPVKFTDTPFTIAARKVRNEPSNQSEPTNLAPSINNSAAPVKASQATAIRSIPPSNNDYGIKNGVCRTIQPEYYHKASSSKDAQLGQSKKRGLNKGSQEKGEHYGPKKPKMKHTGWYDGSGKPVYEEVKPEREKTILEKWEEKEALSKKRSEAAKKGAATRARNRKTKEEEKIKFSILPPNAKASSEYPILQGIERMNDLPLKDRQSHRAQTEQEEARVNVVDKLGTEAINDLICGDSGRHTKNEQDEEMDIDDKFDDEKRGTGNGRMKLTAREISEKERRASMQEILQGKASDTQKKYGKTKASLWAASPLHPSLSSAHSNDHPCPKTKGKNSLDPIDLGSASEEDNSMEQPSTITHLPSSALRDIEKAGESSSEVPLLSSPLDQYRFGDPDTLKSRVIGRGASPNGNQDVRSLGSFEKKDETEKLKRSRTHKEHLLEEARNNAQMLAPQTGMNSRINHRSNVEKLTSDSLRGHIFKARKSKRSSSPEDKSTDKDEEWRTEVPRHGRWNKQALSKSNKRLGRQQSKQPYKPIEIFPKKQYNPKITDNLKIARSPFGDLFAKTDDQGTSTKIRSVGGETKLPLFKPSDPNESKTDCSSNITYTLNTSKGTKYGSTASPIKREKQYRDDDKYTQNGQGTNGGSMISNTNISTASNPSSTYVVKEVYVPIPYSQHQAFYDPNVSSSGGSRHSIEQFRFINKSNNYSDPVVYSNGFAHPNITHSSTNDNRYMHKSQEMEVEEDWTKAWSKSTQLQNSNSIKGIFERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I5Z8</accession>
    <name>A0A1B9I5Z8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_02994</name>
        <name evidence="3" type="ORF">I206_102641</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF50932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012151.1">
        <property type="nucleotide sequence ID" value="XM_019154748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I5Z8"/>
    <dbReference type="STRING" id="1296096.A0A1B9I5Z8"/>
    <dbReference type="GeneID" id="30171363"/>
    <dbReference type="KEGG" id="kpin:30171363"/>
    <dbReference type="OrthoDB" id="1028014at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34776">
        <property type="entry name" value="F17F16.3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34776:SF1">
        <property type="entry name" value="F17F16.3 PROTEIN"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="51"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF50932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC68707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="406" mass="45602" checksum="E3DABB69B4CFF8E8" modified="2016-11-02" version="1">MVSTRSKGNPGVDPNVDNHAGEKRSLPPSSNGKSTKKAKKEQELAEKKEFEIAVQGEPTSETKKEEITGEVGTKDEINQAEKESKDESSKQDSAIDENTVESREDEVKREDKKEIEAGQINDDEPRHGTLESGHIYFLYRPKVETDEAESLDDISKFHILLIPQSGPHSKSHYHRIIEIGKKKLPDPHAKHQVIWGLVSDVGNDKSTLKESFGAYTYETKTRGTRHQGAARPAARGHYILHSPRDELADSPDHNRQRDYKSLLVYEITTPAHEDFGNVQKELSIEEKGAIVLQVKDPDAESRGNPRAAGIPKDKRAQYPKELLNIFRGRRFIPANPVSLLDYKGAELLIITSPHELHDSLGKNGEKIEKDLDHNAKIEKVDIDDSLKELGLNKQDFPEDALEGNWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I6B4</accession>
    <name>A0A1B9I6B4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HECT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_03086</name>
        <name evidence="4" type="ORF">I206_102731</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF51021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012240.1">
        <property type="nucleotide sequence ID" value="XM_019154837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I6B4"/>
    <dbReference type="STRING" id="1296096.A0A1B9I6B4"/>
    <dbReference type="GeneID" id="30171455"/>
    <dbReference type="KEGG" id="kpin:30171455"/>
    <dbReference type="OrthoDB" id="66510at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019193">
        <property type="entry name" value="UBQ-conj_enz_E2-bd_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09814">
        <property type="entry name" value="HECT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="493"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="291"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="534"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="555"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF51021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC68796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1041" mass="115280" checksum="E9F00B171FA0C272" modified="2016-11-02" version="1">MEAIRSIQAEPQVEALDVIDELPPPPAPFPLDQLAISSELNGNGMISRSEQPRQHVRNYLASVQQSCISALSSLLPPESASSHMTSSSESLSSYNAQLASALTDLLEVTYELDELLPPSTNITPSTIHTETFPDADSPADRIQSSFNALTNLLEGLQDARLTDDLTGYQDTDKNEREESNQGGLHPAINVVREELAWQRLESLSTAIVRLSQDRSSSSHETLESNVYSKEGNELSQSTANNGLPPAYQQFIDNHPPSVKENDKSSVLPSYQDIRDEEEASPSLPIEDKSQNADSPISPVTSPGQQSSTREKMLLELDSLTSAIERLSSVVPRLHDQRVEMRHTASSSSSKSRIPITDGHNLSKEDKIKLEKQKMKELEEIWDKIERAHGKRRIMVEDGQRADGEIWERRTKERFINRIVDQAEARRLDDQDSIMGAVDADLARARDLRNRDHFLRDLIDSSEERRLDNQDANIPKTADRKASLIENLMEYSTSGRLHDQDSLPPTPRHGNNGEKIEDPLELVTVQDFLAGGGPDRSRSLGRDTFRENTNGNAEGSSSMARSRSNSVPLDEGIMSKKSISGRSTPTTFKKIAGMMRRGSGQLNLPLKPNNGFDANNIAYVTEHQENLRSVQITLHGIGVSSNLELQVESSMTNDEEAVITSKMNPSISIRIALPTAIQHGQIIPFSAQSLHLEAKLVAQPIPPSVASLLPSYPLSAPDLRKIEPTTLCCTSCERELATLPTDSYKDLPSEHWAEMMEVWMCHNDPSFTARLAEKTKEGFWPQNGGVLVGGSYLLIGKERIKWGNITAEQGDQVEPWNVISCHCGEVLGKQRSKDDKPGAETVRFSKWAVALLKEDDDEEIAELIRFPLSVFVVSDMLELSQAHASHRFIVSEEESGNKRIYVWLFNPSVKMSYAKPTEPSPMPSPLRKSITLDGEEKSRISRRSSIASSIGGKSVQQKVTLSASPGQIVLRAAKIMYKIVEMNGEKDLDDLPGFGLGGQVESLSYPTTICDKLINTLKESSRVYPVGRRSLDAFDIGFLGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I6N2</accession>
    <name>A0A1B9I6N2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Altered inheritance of mitochondria protein 41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">AIM41</name>
        <name evidence="3" type="ORF">I206_03262</name>
        <name evidence="4" type="ORF">I206_102911</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM41 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF51196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012415.1">
        <property type="nucleotide sequence ID" value="XM_019155012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I6N2"/>
    <dbReference type="STRING" id="1296096.A0A1B9I6N2"/>
    <dbReference type="GeneID" id="30171631"/>
    <dbReference type="KEGG" id="kpin:30171631"/>
    <dbReference type="OrthoDB" id="538640at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016884">
        <property type="term" value="F:carbon-nitrogen ligase activity, with glutamine as amido-N-donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.10">
        <property type="entry name" value="Uncharacterised protein YqeY/AIM41 PF09424, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019004">
        <property type="entry name" value="YqeY/Aim41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042184">
        <property type="entry name" value="YqeY/Aim41_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 41, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 41, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09424">
        <property type="entry name" value="YqeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="GatB/YqeY motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF51196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC68975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="184" mass="19891" checksum="781F002597D98E7A" modified="2016-11-02" version="1">MFTQVIARRSLHTSRSLLASQSLLETTLRNALKASMKSKDKPAAACLKSILADVTNATKSGKDPNEPINDEGVMAVLKKGISQRTQASESYSPNSPSPHADNYSSLQNEIKLLQSFLPEAPSNEILQQIINKIIGNLSDEIKVSKGVAGKVINGLWEELGDKKGGVDKKLVGKLVQDALKKIQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I707</accession>
    <name>A0A1B9I707_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="15">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">I206_03343</name>
        <name evidence="18" type="ORF">I206_102990</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14 15">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="15"/>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF51276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC69054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012495.1">
        <property type="nucleotide sequence ID" value="XM_019155092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I707"/>
    <dbReference type="STRING" id="1296096.A0A1B9I707"/>
    <dbReference type="GeneID" id="30171712"/>
    <dbReference type="KEGG" id="kpin:30171712"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000069">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000009">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF171">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14 15" id="KW-0274">FAD</keyword>
    <keyword evidence="4 14 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="10 15" id="KW-0520">NAD</keyword>
    <keyword evidence="9 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="16">
        <location>
            <begin position="106"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OCF51276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="WWC69054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="366" mass="39865" checksum="A943255DE0C48404" modified="2016-11-02" version="1">MATAARFLSSARLARPTLTANVARQSRAYATAPAAGGPNYGLILSLAGVTGIGAYAYLQYNPAAKAEISAKAHELEAKAERKVKGVQSEVDAADQGTGSYAALIKDTWTPFTLTKVAPYNHNSSIYTFSFGEDGQDKVSGAEVASALLVRSLQGEGELKDDKEKPVIRPYTPVSSNEQKGSIDLLIKEYKDGKLTPFISSLQPGQQLLFKGPILKFKYEPNQFDRGLAIAGGSGITPMYQLITHSLNIPDDKTKWTLVFSNVTEKDILLRKEWDNLAKQHPDRLEVKYVLDKAPWGWKGETGFVTASTISKLFPRSTDSNEKVRAFICGPPPQVKSLAGPKDGPRQGELQGAFKELGYTADEVFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I785</accession>
    <name>A0A1B9I785_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Geranylgeranyl transferase type-2 subunit beta</fullName>
            <ecNumber evidence="3 11">2.5.1.60</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I206_02073</name>
        <name evidence="14" type="ORF">I206_104541</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 16">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="3 11"/>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012578.1">
        <property type="nucleotide sequence ID" value="XM_019153838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I785"/>
    <dbReference type="STRING" id="1296096.A0A1B9I785"/>
    <dbReference type="GeneID" id="30170442"/>
    <dbReference type="KEGG" id="kpin:30170442"/>
    <dbReference type="OrthoDB" id="5428259at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02894">
        <property type="entry name" value="GGTase-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000012">
        <property type="entry name" value="Geranylgeranyl transferase type-2 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026873">
        <property type="entry name" value="Ptb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF11">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="12">
        <location>
            <begin position="14"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCF51359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WWC70590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="338" mass="37535" checksum="2035BF8EDA75FB77" modified="2016-11-02" version="1">MSSATASSSSNTKLDTALHVKYIQNLDKRQDLAYHLTSHLRLNGIYWGLTAAHIMGQPSTLDREGVIEYVLSCWDEDAGSFGPHPGHDGHILATLSGIQIMLMEDAIHRINLERVTKFLLDRINDDGSVSGDIWGEIDTRFTYICLSSLSLLGKLDEISSKKKQNIIEYIKKCKNFDGGFGRVPGAESHSGQVWVCTAALSILNRQDLIDIPLLGSWLSERQLPNGGLNGRPEKLEDVCYSWWCLASISIIGKLNWINKDKLINFILSAQDLEDGGIADRPGDWVDVFHTIFGLAGLSLLGYPGLEDIDPVYCMPAKLINRLGLQKPYATLERMTSYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I788</accession>
    <name>A0A1B9I788_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Dihydroceramidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_02122</name>
        <name evidence="11" type="ORF">I206_104588</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
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    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
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    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
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    </reference>
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        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alkaline ceramidase family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="ACER"/>
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        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
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    <dbReference type="Pfam" id="PF05875">
        <property type="entry name" value="Ceramidase"/>
        <property type="match status" value="1"/>
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    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="118"/>
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            <begin position="130"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="155"/>
            <end position="176"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="219"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="239"/>
            <end position="258"/>
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    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
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    <feature type="binding site" evidence="7">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
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        <location>
            <position position="32"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29108"/>
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            <position position="34"/>
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        <ligand>
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            <position position="43"/>
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        <ligand>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I7B4</accession>
    <name>A0A1B9I7B4_9TREE</name>
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        <recommendedName>
            <fullName evidence="2">RING-type domain-containing protein</fullName>
        </recommendedName>
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    <gene>
        <name evidence="3" type="ORF">I206_02149</name>
        <name evidence="4" type="ORF">I206_104615</name>
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        <lineage>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
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    <reference evidence="4" key="2">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
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                <person name="Imamovic A."/>
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                <person name="Murphy C."/>
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                <person name="Priest M."/>
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                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
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    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Znf_RING"/>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
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        <property type="entry name" value="MAHOGUNIN"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR22996:SF0">
        <property type="entry name" value="RE60872P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="499"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="760"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="544"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="676"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="706"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="747"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF51435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC70664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="760" mass="82968" checksum="7370C677046AA518" modified="2016-11-02" version="1">MSSSSHTVTSGWYTNAYSGPFRSTRLRAPSLLPGSARRPVIIPVQQTLVVDVAHNHTHTTTGNSEDNNKNVKRRETIFGPDVGEDDEPGWTESKNQEIGVEKVKEWVERSKNEQGLHATTTLQALVNLKRPTLLLQQIESHSSIEETITPNRSSIEKTDEEDITTISTHPVTSSPQRNSTTIHKKRDSTQIIQTTPLHTLNFKYDATTPMVRIQLEIYPTPKDPLSRLSLSEEEESEGAKEVVEDHEPKIIYSGLHPGGFDQGFTLPYSSALDLSDAIIPIEEQQAQEQAQQDAAAAASAGAGANLNESPNAENASVPEPVVTPPEEGGSRWRRGLFRRNREEDIENAAAIEMTNRANAAAAANNATTGQAGEGEGAGEIPKKKEIEKGMRLLIRIDGLGPEGQALPRKNAQLTHILISGTWVSDHNASTTDTTQLQPQPWAGKRVWVVKVARREAVIGSHTFLLKEIYGLSSTSTSTSNNTQYPPTADDPYASTPNECIVCLTSPRDVVLLPCRHLVVCRDCAVGMVEYGAGGKVGRREDGENTTAETTAGGASGAAAGTSGGTANPTPQVAGGTTTAGRERRKKKVKGWYCPVCRQPYTSLLRLALPESSKPSTGEGEESNELSRVPSRALSVRTTRTTRSILAPSIAPTLPDGAERMLDELRPDDVKARDSDNIEDDQDDFIYESNQQEERPQFVINNDNDNDDNKKIELEHKENIYNSKQEQGDEQISIGNSNAFDLGQPLNDVRKSQEGKGWKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I7F1</accession>
    <name>A0A1B9I7F1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein MPE1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_02196</name>
        <name evidence="12" type="ORF">I206_104658</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012701.1">
        <property type="nucleotide sequence ID" value="XM_019153961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I7F1"/>
    <dbReference type="STRING" id="1296096.A0A1B9I7F1"/>
    <dbReference type="GeneID" id="30170565"/>
    <dbReference type="KEGG" id="kpin:30170565"/>
    <dbReference type="OrthoDB" id="106784at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16620">
        <property type="entry name" value="vRING-HC-C4C4_RBBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DWNN_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033489">
        <property type="entry name" value="RBBP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025829">
        <property type="entry name" value="Zn_knuckle_CX2CX3GHX4C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439:SF0">
        <property type="entry name" value="CELL DIVISION CYCLE AND APOPTOSIS REGULATOR PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08783">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13696">
        <property type="entry name" value="zf-CCHC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01180">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51282">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DWNN" evidence="10">
        <location>
            <begin position="4"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="9">
        <location>
            <begin position="227"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="121"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="393"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="614"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="393"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="455"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="643"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="684"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCF51482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC70707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="722" mass="78803" checksum="610325EBD20F8A88" modified="2016-11-02" version="1">MSTVFYRWGAGRNEQRVTFDGTHISVFDLKREIILGNKMGNGKDFDIGVYDNVTGEEFKDDNHQIPRSSSLIARRLPSSAKGRGNAQNYIIGSSAADSLTGDHRIESHARQAMQDKQNRIAGVRGSGGTFSSLSKRFDGKDELKPGEPSVPISTGNAEEDAKIAAVLAQGAENWEQMQEDMSAGYRAPAARAARTNKPSGSAAGAAATSKYGFGTEHDKEPPTGYICYRCGKKGHWIESCPDNEDPAANERKRFVRVTGIPRSFLKTVETPGGVEGSSGGAMLTADGGFVMAMPDQRQWQKQAAVKPRALTGSDLRESKPLDISITCPICKKLIWEATKTPCCKTSFCEECITSHLLENDFECYECESKIQSLDKLSPNVELREKVSKYVEGEVDRSNKEKEESDEADAKEKEENQEADKGEGVKEGKQNEQDKGEEELEEGAISTNDRNPRPNLDNTFSGNRPQQDENTIIGANGQSINLDTLNPQIINTYLMGAKKMLLNPLILPPARTILNQQIQLLQAQLLKMQMMNINNGGIGMDFNLGQIGMNGNGNNHQNNLNGMMGMMDNGIGMNPMMNEAGSMNGMGMGMNMNMNMNIPMNNNMGMGMNIQNNQFSQQQQQQFPPPPQQFQTHHHQHHQQFNRGRGGFGNRGGFRGGRGGGGGGVGGNLPFAPALTGRLPPSGPNFNNNNNNNNTRGSNIGIKRSAEDEFGSGNGDIKQQKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I814</accession>
    <name>A0A1B9I814_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_02415</name>
        <name evidence="6" type="ORF">I206_104875</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
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                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
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                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
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                <person name="Hansen M."/>
                <person name="Howarth C."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
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                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <authorList>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        </citation>
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            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="6">CBS 10737</strain>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1B9I815_9TREE</name>
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        <submittedName>
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        <name evidence="5" type="ORF">I206_104812</name>
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        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">CBS 10737</strain>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
                <person name="Sun S."/>
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                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Chapman S.B."/>
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                <person name="Griggs A."/>
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                <person name="Imamovic A."/>
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                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
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    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="5">CBS 10737</strain>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="193" mass="20388" checksum="B2948417994D9A39" modified="2016-11-02" version="1">MRPTSSGQRGGAAAVPGSRQGCFKCGNLGHIAENCQAPERLCYNCREPGHESTACPQPRSTDGKQCYACGGVGHVKSDCPSLRGNFGGAIQKCYKCGRGGHIARDCRSNFTGGFRGRGGFNGGFGGRPRPPPVNADGTPVKCYRCNGENHLARDCLAPRDEAAILAAKKCYKCQETGHIAKDCPKAEELPVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I878</accession>
    <name>A0A1B9I878_9TREE</name>
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        <recommendedName>
            <fullName evidence="2">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">I206_104871</name>
    </gene>
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        <name type="scientific">Kwoniella pini CBS 10737</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Tremellales</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
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            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
        </source>
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    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019154175.1"/>
    </dbReference>
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            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="205"/>
        </location>
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    </evidence>
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            <dbReference type="EMBL" id="WWC70919.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
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</entry>
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    <name>A0A1B9I8B1_9TREE</name>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
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    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
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    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    <comment type="similarity">
        <text evidence="2">Belongs to the TspO/BZRP family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057:SF0">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03073">
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    <keyword evidence="7" id="KW-0675">Receptor</keyword>
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        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
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                <person name="Young S.K."/>
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                <person name="Imamovic A."/>
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                <person name="Nusbaum C."/>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
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                <person name="Springer D."/>
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                <person name="Young S.K."/>
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                <person name="Gargeya S."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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                <person name="Nusbaum C."/>
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            <strain evidence="2">CBS 10737</strain>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Roberts A."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
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        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
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            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
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    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
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            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1296096.A0A1B9I8T0"/>
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    <dbReference type="KEGG" id="kpin:30170886"/>
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    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="PANTHER" id="PTHR24419:SF18">
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
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            <dbReference type="PROSITE" id="PS50011"/>
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<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I9D9</accession>
    <name>A0A1B9I9D9_9TREE</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_01454</name>
        <name evidence="4" type="ORF">I206_103542</name>
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    <organism evidence="3">
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        <lineage>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="OCF52169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="WWC69599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013388.1">
        <property type="nucleotide sequence ID" value="XM_019153227.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A1B9I9D9"/>
    <dbReference type="STRING" id="1296096.A0A1B9I9D9"/>
    <dbReference type="GeneID" id="30169823"/>
    <dbReference type="KEGG" id="kpin:30169823"/>
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    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
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        <property type="entry name" value="Het-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052577">
        <property type="entry name" value="VWA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905">
        <property type="entry name" value="NG37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905:SF7">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07217">
        <property type="entry name" value="Het-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628446" evidence="2">
        <location>
            <begin position="25"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="605"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="656"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="717"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="740"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="761"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="778"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF52169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC69599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="791" mass="86030" checksum="49EBB4C208902111" modified="2016-11-02" version="1">MSRAALLFLVIALVALSFTPGVAAFGAGNIPGYSYLEEKAFRHGDIEDIIGNLMKAAGGGFLSRGTKFTPLDVKRVYFGNWLRDYSQAVDVGALKKTNLQTILNVVMVLGFLGIGYATGEFEVTKERLGCYLPTEHIDNPKGYAEGEDARQYDDRLRGPVDPRELEIDPQTGMKNYIANEFGGWATSKALIRQRLQEVIHYGRLFRSTDNKDDSYQAFQLLGRALHTLEDFTAHSNWCELALISLGYNNVFPHVGRNTQIQAPNGKRVYPLVTGTFGGADFIHSVMGEATDHLSQQSVSDLTKQMSNARSISEGQSNSADTLRQLFFSIPGGEGSEMTREMDGIQNMRAGQPGGIDPSQMSPQELHDTLWKILSFRDSVMKRIENTIDRIPGLSGLVEKISNSVSVFIITTLEPFVKPLVGTATAALGQTSQAVIDSHDQYEVWNDPYASDPTHSFLSKDHFGLILNQPAGEIAQIVVEYTVKLVVQAWDNNSMPVEQVTEPVLEALFHPEFHNGRSEIQKRMLDKMKNWIDTVHQKQEILNRLTSDKVKAGGNRRIGDTSQSTGHVHNQLLPDGGLQQVVASHNVHVPGAQYLNAGQDLLSGKKPWDQGFGSGGPNAWRDLNPNVPESGIGQASSFYNNDPSQNQHQGQYGGGSYQPPHQQQYQSQGGHADTFYGQGSQQPSGYGGPPQGGYNAPSYPSSDDYPGQGHHNQGGYGGPPPLDRYGGPPPDQYGGPPPDQYGGGFGGGQPTYGEQMAQGGHHGGHSGHGGHHRPPGQWGNQGGYGGPPGGWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I9X6</accession>
    <name>A0A1B9I9X6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_01712</name>
        <name evidence="7" type="ORF">I206_103282</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013641.1">
        <property type="nucleotide sequence ID" value="XM_019153480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I9X6"/>
    <dbReference type="GeneID" id="30170081"/>
    <dbReference type="KEGG" id="kpin:30170081"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF177">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER MCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="450"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="479"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="122"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCF52422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC69344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="531" mass="57996" checksum="C57921DEF074023D" modified="2016-11-02" version="1">MSITNDTSLEEKDTITPNIQPVSKTRSHSQSHYQRSRPEVDPFPIQLHLSRSLSHAHQPNHSLHRPPTRNDGYDNFPPPLQGIRNSADLERRLTTDADLVGQMAVNDDDIGPPPEGGKDAWLCVASAFFVLFCVFGFVTVFGQLKVYYLAHQLKEYSQSDVAWIASLQVFLTFGGSIVAGRFFDSHGARGLVMLGTSLSVAAVIAIAFCKLYWQFLLAHALFGISASMLYSPSTAIAGHWFMKRRSTAVGIVVCGSGLSGVIYPIGLKRLFDELDFRNAMLIIAGMNAVLMFPAWFFLKARLPPRSPPPLKSLKGPWKEPRYTCLVLGSCLVMMNWLSPYFDAPNLITSNKVTGPISDYSIAILQVGSFFGRASSGVLADKFGVWLIFILSILGCSISILAFWIASPIGSGCVIVGLIGYGFASGAWITLVAASTATISPIREFGMRLGMLWSLTSIPSLIGPVICGVLISSADGTFKYAGLFIGLTQFLGAFITIAPKILDYVRCLQEKKETRRGINKQTEKKTSSAQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IA94</accession>
    <name>A0A1B9IA94_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_01679</name>
        <name evidence="4" type="ORF">I206_103315</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894008">
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        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC69376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IAI4</accession>
    <name>A0A1B9IAI4_9TREE</name>
    <protein>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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        <name evidence="3" type="ORF">I206_103061</name>
    </gene>
    <organism evidence="2">
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        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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            <taxon>Fungi</taxon>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
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            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="OCF52642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
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        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
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        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
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        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF52642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC69125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="88" mass="8994" checksum="1A2618D8487706E9" modified="2016-11-02" version="1">MAAVAQAPPMLPSTSSTGSISRPSSSSATAKPSESKTLNQPSKPEASDKTGAKVIVSEATPVDEKSEVKKENGDASPTNVIFHSCHSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IBD4</accession>
    <name>A0A1B9IBD4_9TREE</name>
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            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
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        <name evidence="3" type="ORF">I206_101063</name>
    </gene>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="OCF52962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
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    </dbReference>
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        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF20">
        <property type="entry name" value="FLAVIN-CONTAINING AMINE OXIDASEDEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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            <end position="276"/>
        </location>
    </feature>
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        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="OCF52962.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC67156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="525" mass="60470" checksum="B0A753D719402D92" modified="2016-11-02" version="1">MARNSTSSNRKKVLIVGAGAAGMSCADGLSNHPDRFDVTVIDAQAYCGGQAFSIPIDKKYGANWMNQGVQGGSYIYQHTFHHFRKCGYEEEPVELQVSFGKDDKFWTNLFPTNLVNKHSNDIKKFNKFLKLIRWTELFWALIPIKISCKIAGLSDEFLDFMLFPSLALFLGTGNATPDLPTVMMERLYTSPTYGMWYPHDPKSMSSNLPPMVVFPESSEFYRTWQGKLEERGVTIRLNTELAAVTSRNPKVKVMLRPRRQQEDLHNPEGADQDLPSQEETYDEIVMCTLADTAKRVLGKQATGREKWVLGNTKWSDDITVTHTDIDYIKKYYTIEFDENQAVENINGRDDSSRVRKGEKEFQPMYLIKQVPKNSRLLEMCFDCSAFQYQLNKSLPLKDHIFQTIFLNNKDENTWTKNEIDKTKIIREDWWHQLCHSWTHYAFVVPFIWLLNRNSKHTTFAGSWTLVNAHEVAVISGTAAAYKLGADYPEDLYKNDFARKAFKSYLFLTHGLTLAKNRIRKSSLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1B9IC24_9TREE</name>
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        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
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        <name evidence="6" type="ORF">I206_00460</name>
        <name evidence="7" type="ORF">I206_100866</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC66959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014378.1">
        <property type="nucleotide sequence ID" value="XM_019152240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IC24"/>
    <dbReference type="STRING" id="1296096.A0A1B9IC24"/>
    <dbReference type="GeneID" id="30168829"/>
    <dbReference type="KEGG" id="kpin:30168829"/>
    <dbReference type="OrthoDB" id="2565042at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd21075">
        <property type="entry name" value="DBD_XPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.530.10">
        <property type="entry name" value="XPA C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
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        <property type="entry name" value="XPA_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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            <end position="574"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="475"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="7"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="548"/>
            <end position="574"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF53159.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC66959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
    </protein>
    <gene>
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        <name evidence="10" type="ORF">I206_101086</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Tremellales</taxon>
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        </lineage>
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    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the gamma-BBH/TMLD family.</text>
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        <property type="protein sequence ID" value="OCF52940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC67179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014159.1">
        <property type="nucleotide sequence ID" value="XM_019152021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IC39"/>
    <dbReference type="STRING" id="1296096.A0A1B9IC39"/>
    <dbReference type="GeneID" id="30168610"/>
    <dbReference type="KEGG" id="kpin:30168610"/>
    <dbReference type="OrthoDB" id="406634at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045329">
        <property type="term" value="P:carnitine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
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        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF25">
        <property type="entry name" value="OXIDOREDUCTASE AIM17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="8">
        <location>
            <begin position="339"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="122"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCF52940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC67179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="624" mass="71238" checksum="F534513C7E5A236B" modified="2016-11-02" version="1">MATRIPVALTYSPIRHGVTSSSYTRNFQRCYQSTSESNPSSSASRSSYSRANLATLAAEGDLVVPDKTSGSKSLQTPNKSHPIPNQVKPLAFPPPKLKANPYAPNYAISEEDLDEPIEFANDPLSSDVGAENYASSSNSSIKGQSHHAATTLEEPNRGSHIDWNRNDSQTDRRESFYQMEGKTIELGVLESVTLHKNYIIYKNRTNIDGGVITWGRLRDSCTCKLCRDPNTSQKTYTTGQAMRKAYDNHPPLIEGIDLNSGTKGLKITWGNNKGEKSHISFFSRSKLRYLCEANSIKEGHYPSQIFNRKLWDSTSISNNQSLKLPYDMIRSRKAYTMLRLLEQLHTYGLVIIEGVPTNPTNDEDCHLRKVMGWIGEIRNTFYGETWNVKSMPQSKNVAYTNVDLGLHMDLLYFSSPPRIQALHCLRNRVNGGISYFVDSFKVAMDLPEDLYKTLTSTYIPYIYDNDNHYLRYSHKVIEDFGKNGNLISNPHTAINWSPPFRDTWVPSSSDNDEMNLEIKAKNELNTLWSITEFENKLNDSKYKLEFKMKEGDLILFDNRRILHARTSFYDKSIEEIKNEKIQIIKGEPNRWLKGCYLDGEVLWDKLNVLKKQIEKEKLLKDLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9ICD2</accession>
    <name>A0A1B9ICD2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_00580</name>
        <name evidence="3" type="ORF">I206_100747</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014498.1">
        <property type="nucleotide sequence ID" value="XM_019152360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9ICD2"/>
    <dbReference type="GeneID" id="30168949"/>
    <dbReference type="KEGG" id="kpin:30168949"/>
    <dbReference type="OrthoDB" id="10369631at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628515" evidence="1">
        <location>
            <begin position="19"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF53279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC66840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="100" mass="10229" checksum="6639FF913342A405" modified="2016-11-02" version="1">MKLHFVLLSLLPAIAAQAQDVEWPSPTEGYDINAARELYSSQSAKLGGSSTTVIMGFPTAGATAPTDACDQSDDPVKRGVTQVGGGAFIAPTAGPYGMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9ICG9</accession>
    <name>A0A1B9ICG9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I206_00517</name>
        <name evidence="14" type="ORF">I206_100810</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014435.1">
        <property type="nucleotide sequence ID" value="XM_019152297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9ICG9"/>
    <dbReference type="STRING" id="1296096.A0A1B9ICG9"/>
    <dbReference type="GeneID" id="30168886"/>
    <dbReference type="KEGG" id="kpin:30168886"/>
    <dbReference type="OrthoDB" id="44789at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000011">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1280.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF9">
        <property type="entry name" value="ANION_PROTON EXCHANGE TRANSPORTER GEF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9" id="KW-0868">Chloride</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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        <source>
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        <source>
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        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF53216.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC66903.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="885" mass="98011" checksum="1E106EEF97E47B78" modified="2016-11-02" version="1">MSYPPNSAGQDVFEEHELLAAEIRHNRRQSDTELRAEEAEREDLMRRYEDFSTVDWIQDSLLERTVQSKGPTNPFIARLDRIDGAFGYVWRLIRRALEEGESWVVISLVGVIIGISAGMISIITAWLSDMKLGYCTTGWWLTQKYCCLEITEEFESCAEWRQWGGIWPLGWIAYIIWAAAFAFSAAFLVKNFAPYAAGSGISEIKCILGGFIIKGFLSVETFLIKGLTLPLAIASGLSVGKEGPSVHVACSIGNSVARMFSRYDRSHLKMREIVTASSAAGVAVAFGSPIGGVLFSIEEMNQTFSNRTMWRSFVCALVATFTLASVDPFRTGKIVLFQVSYDRDWHYFEIPAYILIGIFGGLYGAFVIKFNLQVAAFRRKHLANHGISEAVTLAIITAFVGYMNRFLREDMTESLSLLFRECEGGGDHEGLCQTSSQWRMVNSLLIATVVRTALVVVSYGCKVPAGIFVPSMAVGATFGRMIGILVKAMHTSYPQAPWFAACAPDAPCITPGTYAFLGAAAALGGITRITVTVVVIMFELTGALTYILPTMITLLVTKAVSDQFGGGGISDQMIRFNGYPFLEKEDKEDTMDKAFIEPIANMMKKDIITMSATGVPLQQIAEMVQSTSYQGFPVVKSDTDRTIVGFVRKNELRYALDKARRTRNLAPDAICTFQHTPPLTLPPDKDLEAERLQRPESVVPGRTGSIFRTPSVGAGGFVRRESGMEAEEVDFGEYVDEIPLTVSPKMPLEIVLQLFRRMGPRVILVSDQGKLVGLVTVKDVLRHEVVEHQKHTRLTSANTTISPLTTRNPYSHTREESTSSTGGGGWDLGLNLTNREEGGNNGLEIVLEEGFSWIRIQGSRIYNILHERFRFRGNTTNVDFDLNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9ICI2</accession>
    <name>A0A1B9ICI2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_00402</name>
        <name evidence="3" type="ORF">I206_100924</name>
    </gene>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9ICY5</accession>
    <name>A0A1B9ICY5_9TREE</name>
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        <alternativeName>
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        </alternativeName>
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            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
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    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the conserved oligomeric Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the COG6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014727.1">
        <property type="nucleotide sequence ID" value="XM_019152589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9ICY5"/>
    <dbReference type="STRING" id="1296096.A0A1B9ICY5"/>
    <dbReference type="GeneID" id="30169182"/>
    <dbReference type="KEGG" id="kpin:30169182"/>
    <dbReference type="OrthoDB" id="272987at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010490">
        <property type="entry name" value="COG6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048369">
        <property type="entry name" value="COG6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048368">
        <property type="entry name" value="COG6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506">
        <property type="entry name" value="COMPONENT OF OLIGOMERIC GOLGI COMPLEX 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20653">
        <property type="entry name" value="COG6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06419">
        <property type="entry name" value="COG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01087">
        <property type="entry name" value="COG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric complex COG6 N-terminal" evidence="13">
        <location>
            <begin position="101"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved Oligomeric Golgi complex subunit 6 C-terminal" evidence="14">
        <location>
            <begin position="243"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="62"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="130"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCF53508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="WWC66611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="783" mass="87775" checksum="012E530A0068AA1E" modified="2016-11-02" version="1">MSARSPPSTDSPSRSLSLSLSAPTSIPSSRTNPISLRIYKTIGTSFDDSSSKEALELVSSFYSSSSSSSSTNKGKGKAELQDGPTSESEPEGLPRRRTLKGQSAATARKWLKKDVESTLATGSQNFLKAFEEVDQKLQVLREHMREMQVRCDQVQSELDQANSGTKYLLERADGLRSQRASAQLRQSLITLFLSKFTLSEAELAALGSREVAVGQALFDALDRTEKIRKDCEVLLGGEEGKMQAGLDIMRATSDQMESGYKKIHRWCQFEFRQFTRETQLEVSPVMREGIRRLRERPPLLKDALQGLTSTRSASILQAFLDALTRGGPNGLPRPIELHAHDPTRYVGDMLAWVHQATASEHEFLDGLFGVKDKQRMVGAEREWIYPEGGQEELMVAEAMDKHLEGLGRPLKLRIQQTIKSQEGIIMSYKIANLLQFYLITMKKTIGEEALLCKTLQEIHDQAYIAFFENLDAQGRSLLRFLHPPDATLSPPLALRDFCLILRELLSVYSTSLVDPSEREADSDLAKLLDKSVDPCIEMCERMAEMRRSSVGGEWEKDLFMVNCLGYLQHTLEIYDFTSRHVVMLEGKVRDHVESMTYEHHGKLLEQCGLSPIMRTIRTRPADTPLSRLPTTNPKSLTAALATFSNWLITIDPSNSPRLALLSSARLADIIHRKALKKIYEAYGEVCERVLDPKEGYEFGETMLRRGREEVGVALGVGEMDDDWDEEDTEKFSDLVEQPVDNDVRFNEGEENRQILRRDSGVGLGLNLGEGEGNAGQVETDNQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9ID93</accession>
    <name>A0A1B9ID93_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_00686</name>
        <name evidence="6" type="ORF">I206_100639</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014603.1">
        <property type="nucleotide sequence ID" value="XM_019152465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9ID93"/>
    <dbReference type="STRING" id="1296096.A0A1B9ID93"/>
    <dbReference type="GeneID" id="30169055"/>
    <dbReference type="KEGG" id="kpin:30169055"/>
    <dbReference type="OrthoDB" id="1740265at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033934">
        <property type="term" value="F:glucan 1,4-alpha-maltotriohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004574">
        <property type="term" value="F:oligo-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000025">
        <property type="term" value="P:maltose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11332">
        <property type="entry name" value="AmyAc_OligoGlu_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000001">
        <property type="entry name" value="Maltase A3, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF179">
        <property type="entry name" value="NEUTRAL AND BASIC AMINO ACID TRANSPORT PROTEIN RBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="4">
        <location>
            <begin position="18"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF53384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC66734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="562" mass="64702" checksum="74F050A6B1F256A1" modified="2016-11-02" version="1">MLQRNPDSDWWRQAIIYQIYPRSFCDSNGDGIGDLKGITSKVPYLASLGIDAVWLSPFYPSGLKDGGYDVSDYRDVDPRIGTLEDFDEMSKAFEEVNIKVMVDIVPNHSSDEHVWFQEALKAGKGSKERERYIFRDGLGPNKDIPPTDWQCAFGGSSWTTSGCNDGQWYYHMFDSSQPDWNWDNMEIQEDFIKTLRFWANRGVSGFRIDVAHALVKDFNGNLPNWKEMNEIREKKLKNGNKHITHPYMDRDEVQEIYKDWRKVFEEYNPPLFAVAECWVAPDRKPMYASQEGLGQAFSFDMMLCNFDAKEYRDCIEHSLKDSKQAGSSTTWVLSNHDEIRHVTRYGLPNVPNAGYPEFDDAFNAYKRSKFTDPPVDVATGLRRAKAATLMILGLPGSTYIYQGEELGLPEVIEIPDDQRQDPHFHRTKGECLGRDGCRVPLPWNSTCKNLGFSNDKPPHLPQPEWMEEYSVNLQDNSSESTLNFYRKALEIRKELQCEEELEWIENDNLEVLHFSRPGKWEIFMNASKKAISIPKGRKVLISSNEIIEGILEGETTAWLLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IDJ8</accession>
    <name>A0A1B9IDJ8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_01075</name>
        <name evidence="6" type="ORF">I206_100250</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014987.1">
        <property type="nucleotide sequence ID" value="XM_019152849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IDJ8"/>
    <dbReference type="STRING" id="1296096.A0A1B9IDJ8"/>
    <dbReference type="GeneID" id="30169444"/>
    <dbReference type="KEGG" id="kpin:30169444"/>
    <dbReference type="OrthoDB" id="3819888at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_7G04540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF53768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC66349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="308" mass="32895" checksum="F279413107D0A1BD" modified="2016-11-02" version="1">MSDSSHSLNNSVVGSDALTISNLFNIKGWVAIVTGGGTGLGLCTASALAANGAKVYITGRRLEPLEKAAREASPKEGGGQLIPIQADASTKEGIQKMREVIESKEKWVNVLINNHGVSLGHADPNAVEQTPEALSKEMFENESFESWLNAYQINTASYYFTSFAFLPLLSAAKTVGGYPEPGNILNLGSVSGITKTSQKGQFSYNANKAATISLSHQLATEFARRNLNIRVNVICPGYYPSGMNTMQGQYAGGSDESLEFARKKWGIPFGRAGNAVDYAQAIFSLIANQYVTGAELVIDGGWLLVQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IE05</accession>
    <name>A0A1B9IE05_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription initiation factor TFIIE subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_00960</name>
        <name evidence="5" type="ORF">I206_100365</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIE alpha subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014873.1">
        <property type="nucleotide sequence ID" value="XM_019152735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IE05"/>
    <dbReference type="STRING" id="1296096.A0A1B9IE05"/>
    <dbReference type="GeneID" id="30169329"/>
    <dbReference type="KEGG" id="kpin:30169329"/>
    <dbReference type="OrthoDB" id="361102at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039997">
        <property type="entry name" value="TFE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017919">
        <property type="entry name" value="TFIIE/TFIIEa_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002853">
        <property type="entry name" value="TFIIE_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097:SF7">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00531">
        <property type="entry name" value="TFIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51344">
        <property type="entry name" value="HTH_TFE_IIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH TFE/IIEalpha-type" evidence="3">
        <location>
            <begin position="14"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="395"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="413"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF53654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC66463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="462" mass="53197" checksum="BA0EC703A861311E" modified="2016-11-02" version="1">MAQPLSSNEINKLCANLVYQVAYAFYDTPYIIILKMMVHDNVTTEMELANKIGLTSPEVRKYMGTLHMHRLVRRHVNKEKVPIPEWRLKQLAAQPEKLNQPIKPGQPKPGAIDKDGKPLIIERERTKDVHYWYLDYREFANVVKYRLAIMRKGIDDKIKQEVGHRGYICPLDGKTYDPLDLSNIFDPFTNTFKCEDCQTELIEHDPSTALDGKTTTSQDAMQRFNIATSPIREALKLVEAQTVPSLNIIVWISQNIKTTVKGNGELDEQNNEKEKKFEVVIGKDENEEKEKERLAQQQREQNALPHWYTHSTVTGQATTLGIADQKRKQILAERNKFNENEKEFQDESLKAHYEILDENEQGEDEFEETPTPTIEKEIQIPSIKIENAIDMLEDDEDDEEGMEDISSIPNGINKEDERGRREGNGQMVNVAGIPKNIEDVTDDDYELMSTEEYEAYAQAMYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IE65</accession>
    <name>A0A1B9IE65_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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            <strain evidence="2">CBS 10737</strain>
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            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Abouelleil A."/>
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                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
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                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Murphy C."/>
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                <person name="Priest M."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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                <person name="David-Palma M."/>
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                <person name="Bowers K."/>
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                <person name="Mohammad A.W."/>
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                <person name="Yurkov A.M."/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1649"/>
            <end position="1659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1712"/>
            <end position="1729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1768"/>
            <end position="1789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1796"/>
            <end position="1817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1826"/>
            <end position="1836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1872"/>
            <end position="1882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC66568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1949" mass="212046" checksum="07D9AA8D93C97C42" modified="2024-07-24" version="1">MSQITSAIPSTSSSSSRHHQIMSTATTVPLKVPAPISNNSNPNANAYASGSISRKVGGKELRSSRRRGGSTGPPVILGGGVGAIGKAAELGVQNLDPYSTLYNKPAVAQKSRSTSPAPNIPLQQPTVAYPSPPKSPIFASPTSTLQSGSATSEKSGSGSGSASRHSNSSRSRQSRSPGPNPSVPSASASTSTNSLSTTASTSSRTLKTPHSTKTEHNPIIASASGSTLDHTSSPSVPLAVQRAKSIQQQNHSPTPVRTQVPPMAQGPLPPTPLIDENKYRGSTEPLNIPPNRGRTPPPLEVKENRLSQNWIHIETPDRDKDGSPTEPVIPARNNARLPVAKMIPVKKLSSDLAPTDRPLLERNQSAPPLSPTPQPQKGARKSLDQLRTTSPSPASRSRQASLSTPPTSILDAAIPNSSHSLWRNGSPKSEKPPMFTRRSEDLLRTTNETAPTKKEIRAMQQRTLGVASTAGLAPPADLEKKAAGLSLKKSSGALKALFQRGASGKGKEKEKSEITSVTRRRPSGDELRRPSRDESRRKSGDELRRPSGEQRGRPSLGFRPSLSPVQNLSGEASKTQGRASFSADRTMYPTPPPIIRAASTDASPLLNVAGPSKPHTVSQDTVQPKTATQFAQLRTVSPASAPSEQSPETPSSDIIPSSSLPYLSAMANRVSLAPPAVIAPAPKMEEISSVGKLPESSGSTPRASDATPTEISPIKYSKSLHLLSLPDLDLDFDLGFDKFNARAFHIGESPSTPRRSPRSPRSPYRRAKASSRESPARSYSTRSPRATPIPPTLQRTASERRRSQSFDGPTDSIPMLDDFWKSPSDMGTSVNSTATTGYISPSVAKFFAAASSSSVPMLSKPQVSPKKLVSLAPEFDEVRSRSRSRSNSSRISSSDHIRTPSNASSTNETPSPSPPQTPPERHLEGLGFGDISPEGTVIAETPSPEPAQIKEETVIIKKPAELSIAPNIPLPATPVALASPALIESPKAVEHEGTVVEEKQELPKPRKRDMSLMSRSLIVNPDPSLTIRALGKEVERLLYAFRYPSQGVTSADRATMLRNDLLNVMLEVDRRAYDSAEEPAYIMLRAACFEWCDALLFELRVEQPANERGACLEGLAAVIESACLSEQALKQSPAHQAKFTQMMIKCMTFVMSKLGAKGVFHNTLLFSGRFLAFAFFRIPHVGEQLVTVLQPPKGALMRFTKSIMMGVPQCPVKPEYPRHLLPLCFDNSRAYTARLASLSAEFPTEEERDAFLFQPGNWLRRWQSDDSELFPAFYRAYHRQLAIYLGPVVGYYESLNRPLPASELMRAPGYAHLATIFAKKCHSYILGSVNAVTTSSSSTNFEATETAGFRGSQKPPVLETANRRLVETISTFANLKVMIPDYQKRRMIECDGTQLWTDMIDIWTKNLISKTSLYAPKGVFSLFDLLDGIVDPPYETTSFSISELGHAQQLESQPIHSLLDIPHLIYVVRLILTQGEHALTLVKAIAFVFTHWEVLTARSEDRRELCLGLLLQKDLFERLLLFWSQSVRSYVLRLVVFRLGHIHTKKEDGSAHLVEIESVKLLQTRLNRIKRRHDELEPKSYGLEDDNTKEEPIPLTPVSENGFGSIGMPRSKSTITMVADSPKYAPPVNKAEKLLGLGLGIENQDRKSSSATRSTQDGSILQRGETDELPGSAGKIGKATNWFKKSFGNKKKRKDNSSNSPSPSNTPVLGEDSSSTPEAFGGSPNSNKASPKMMIPEIHTEDASPNLKTIDCPTESTGNERKGKPATIITNSPYGKSQTSLNSPKNGNFSFEFELPTTSPRSDTFDPTPQLPSSPSKPLTGDRRLSQGSQIQTPVSPNKREPPSPHMSKSFSKRSSLLPPKTASALEGLIGEEDKEKLRSIESHSSYSIKQEEDKGYDKKLHAYAIRMLAELEDAQKEYDEWWSEGGVGKVDGAPPRLTVAWPFHEGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L1Y5</accession>
    <name>A0AAJ8L1Y5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_101562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058518.1">
        <property type="nucleotide sequence ID" value="XM_070202417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L1Y5"/>
    <dbReference type="GeneID" id="96955705"/>
    <dbReference type="KEGG" id="kpin:96955705"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC67652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="136" mass="15712" checksum="B8949E59006E06BC" modified="2024-07-24" version="1">MSFEPLKIPLSPRTPCALLSNLILSPKPNTSSMFDITNNSIMSIISPILPNFNFSSNQLKNSPILKKENLIEKDNSNNNNNELNKNINLEKENKINFRSLTFKESLQISKFILEEKEKINNFHNKKIIKKKIIKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L299</accession>
    <name>A0AAJ8L299_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">STB6-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_102007</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC68088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058592.1">
        <property type="nucleotide sequence ID" value="XM_070202491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L299"/>
    <dbReference type="GeneID" id="30175269"/>
    <dbReference type="KEGG" id="kpin:30175269"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070822">
        <property type="term" value="C:Sin3-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038919">
        <property type="entry name" value="STB2/STB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059025">
        <property type="entry name" value="STB6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31011">
        <property type="entry name" value="PROTEIN STB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31011:SF2">
        <property type="entry name" value="PROTEIN STB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25995">
        <property type="entry name" value="STB6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STB6-like N-terminal" evidence="2">
        <location>
            <begin position="62"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="596"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="638"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="673"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC68088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="966" mass="107333" checksum="AF1E5DE90926847C" modified="2024-07-24" version="1">MSFTLSPTSISSFSPSPSVPSRFSSPVPSPSNAQTKEALLIPTDRPLEELEEKWISKLGRLKVEKEVTLRGYALYSLRSWFLSRTHFSHTIVTQTGKPTEQISAYLLVPLPSLSHHEAAVEVANAIQFLASEFQSSPRKTEYGTLLVTTPSAFGQEVNPVPGGDFRVAKPFTTVNTGLRRLGCGGRAVIGLESPIPALRRKFHELYKIPQPTHPIIPLSRNSSPSTSPKDAKTFSPSPLADNTQADITSDPFTFLVIELVKLIQASLTLWGLFCSPSNNLEIDGLFCDETKAGIFQWRRIMGMEHEESLKLEKETSGGCIDPKTLSALLSSVTSVHYEMDALGVEKLPKDPFSNYRRLLKTWTGFQTGNSSLQQPIQYLTVSSIRSLTQHYLADRTRHHGDALKVHRLLFNGVAQATSSISANLKGGSTEDTPIRKREHHLRFRGEDEDDQGVGLIIPEGEVGPVAPPDVITTDLEAYIKGILRSREKDWDIMGARRVAELWNGTVAESDTGRRRKLNGRMGSMNSSTGNIRDSNRGVLRKKTQSRDFAIGQSAHLGIKEDDEGDGDFKGAFKEISGRAGQAIKGGFGLVSRKGTNYETSDSETGTAAPSSSKSSIMRKRQSIVPLVIEPDLEVVDEQFDRDQSASPSPSASHRLLDRSFNNSSRPSFLTAGSRAQSKRPSIVTQPSGNDSDIWSKTSLGNGLSPAEEKSDMEFTANGYSPGGHSRTPSARGIPYIEGRPAHTRTPSDRAIAWRERGRATTMLRTASDGADVVIEETGMEWEVTNPHGTGKRDGEIVGQRILELTRRHSLEQVDFYKDMRRVEPEHLQIDVEMCAVVLDLREREKQLSKRAKDVKLLEESVFQSLSQFVASAKNRRAHVEDLRIASEGIRKQIESLDVDDEHDNSPADRFHYYLSEETHRPELLDDLGRLKEMWEGIRRSQEEKRKVVDGEIGLDGGTKGKWWNWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L3I3</accession>
    <name>A0AAJ8L3I3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glicosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_102598</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058693.1">
        <property type="nucleotide sequence ID" value="XM_070202592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L3I3"/>
    <dbReference type="GeneID" id="30171321"/>
    <dbReference type="KEGG" id="kpin:30171321"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF165">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="4">
        <location>
            <begin position="160"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="3">
        <location>
            <begin position="314"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="5">
        <location>
            <begin position="679"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC68666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="878" mass="98594" checksum="1B2C07D08C26BAB4" modified="2024-07-24" version="1">MPIVERELEGFTLVGSPKAGSSISSFELKNEKGRFKDFTYKLSFPFASVYRIILTGPDRPRPPHDNIILPENPLSFKLTSLDTKNCKATFDFPEGRGGESAASKFDGSNRKRILELSWKEHITLNVYEFIGKDKVRIIGDLPNRSYALTDKGIIRHWWVEPDNLHLGLGEKAAPLDLSNRSFTNSASDSAAYDAYNTDPLYKHTPYLISTPKPTKEGAEVVSTYAIYHPTNSAGIWDVRRLHDDPWGHFKAYTQDYGGLEEWVMVGKGVKEIVRTFAELVGRPKLVGRDWLGYLASGMGLGESDHPPAQELLSTWPDLCRKHDIPCSAMHLSSGYTVDPATGNRYVFTMNEDRYPDFKAMTAHFHKHGIKVCPNIKPYALVTHPQYKQLQEADAVFRDPAVDEQVVTRIWSAGVGDNEKGSWVDMTSEGGRKWWADGVKSLIDLGCDGMWDDNNEYFLHDDEFVSQTTFPHQLYSPAEGKASIGLLGRLLNTELVNYVSHNELIKAQPDRRPYVLTRSGNVGTFKYANSTWTGDNWTSWHNLRGSQAIQVNAGMSLMQSTGSDIGGFGGPLPSPEMFVRWVQLGVTHSRFCIHSFKPDKNDMSGAAATNTPWMYPEVLPIIREQIKWRYEYLPFFNHLMWLSHEEAIPSTAWLGYGDFSSDHNLYNQEILEGFDAWLGVGNILVCPALFEGQLTREVYFPKSSSEDKSLYFDLHSPHRQYTAGTRTTIATPLEHFGLFVREGSVIPIGKKQHTVTEISGPARTTPDGIDVQLDSEGGLVGLDDWRGIKIFPSKNGKSHQGNWIEDDGISLKPAKTIISVTYSGKEHSVDVEVSFLQNDFKTLWGKTLDILLPEGDVRKVVGAKEGIRDGRRVWTIEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L4R1</accession>
    <name>A0AAJ8L4R1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA polymerase</fullName>
            <ecNumber evidence="13">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I206_103961</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the DNA polymerase type-X family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="13"/>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058961.1">
        <property type="nucleotide sequence ID" value="XM_070202860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L4R1"/>
    <dbReference type="GeneID" id="30172835"/>
    <dbReference type="KEGG" id="kpin:30172835"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00141">
        <property type="entry name" value="NT_POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.210.10:FF:000005">
        <property type="entry name" value="DNA polymerase IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.210.10">
        <property type="entry name" value="DNA polymerase, thumb domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002054">
        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019843">
        <property type="entry name" value="DNA_pol-X_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028207">
        <property type="entry name" value="DNA_pol_B_palm_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022312">
        <property type="entry name" value="DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002008">
        <property type="entry name" value="DNA_pol_X_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
        <property type="entry name" value="PolB_thumb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276:SF42">
        <property type="entry name" value="DNA POLYMERASE BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14792">
        <property type="entry name" value="DNA_pol_B_palm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14791">
        <property type="entry name" value="DNA_pol_B_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00869">
        <property type="entry name" value="DNAPOLX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00870">
        <property type="entry name" value="DNAPOLXBETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00483">
        <property type="entry name" value="POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00522">
        <property type="entry name" value="DNA_POLYMERASE_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9 13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BRCT" evidence="14">
        <location>
            <begin position="27"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WWC70017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="585" mass="67205" checksum="6C9C6FFA078D2519" modified="2024-07-24" version="1">MPHRPPAHPLPSASSSSLHTPHSIAPTLYQLFANMTFHIISAKLETEIAKIYECIDELGGKCVGIEECNFVISAIKGKPRLVRSLGEWMNKKPIFTPEYIFDTYTSALEYAANPDPSQPPKLPKRSEYIVHPGPVPIKPIRPINGYARFIESDEEYDEELKPASKKRRLSIKQEDGVAEKVKVEVEDISYDNQHPRIELLKDMTLLPDDIKLVDIPALCIHRGSPLICVNQDMIDAIRPILEEREFEEAQQKNSNVLSYRRSLSIMKAVPYPIRSGKEAMKLNGVGEKVAQRIDEYLQKGFIADSVKILNSSRYQSLKLFATVYSIGHHTSKELYDRHHCRTLEDVRMHFEAIEEESPEARLKDKLRRRRRGGMKQVEIVEEWIKLKDELDQKISRKEVEEIAECVMEHLEAYIPDCDYTICGGYRRGKTESNDVDIVFRPPGMDQDIGLLRDLYLRLSDLGIITHVLHVTHREMNVPIHASPANFDNLDKAFVILKLPGPGRLHRRVDLISSPNDRYASAVLSWSGSMMFERDLKRYAENVRRYKFRAGLIEMSTGDEINLETEREIFEFLGLKYVPPEMRNAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L4R6</accession>
    <name>A0AAJ8L4R6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">L-lactate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_103511</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058883.1">
        <property type="nucleotide sequence ID" value="XM_070202782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L4R6"/>
    <dbReference type="GeneID" id="30169854"/>
    <dbReference type="KEGG" id="kpin:30169854"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF101">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE (CYTOCHROME B2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="8">
        <location>
            <begin position="94"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="9">
        <location>
            <begin position="208"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="180"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC69568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="599" mass="66568" checksum="BF1502045B13C359" modified="2024-07-24" version="1">MPNFSPFRKAVLNLRANPQSFLSRRPLSSQTSSSSTNTINQKFIIGAGLAISVPTYLYLTRARLDYQPDTVPDKVNSDVPDQVRSSQSGNGKQIAKISARDVLDKKDSNEFWVVINGDVYNVTEFLDEHPGGREIIESNKSKDVSYIFNPRHPSDQLNNENLPPSVKHLGKLEINNEEEKEKLKLNISKSETDEKELIKKKREEFEEKGLGQIINMRDFEKHAEELCSKVAWGYYASAADDEITKESNNSDYKKIRFRPRVLRPVKEVDSSTKILGYDSTIPLWISPAAMAKLGHPDGEVNLTKGAAATGIIQCISSFASCSVEEITAARTNNQPLFFQLYVNSKRHLAKEVISKINRLGFNAILLTVDAPVGGKRERDIRVKGEFEAPKSDAYDKQGDTKGVAEAIFSAVDPDLNWKDLKWIREQTKLPIIIKGVQTVEDAVLAYKYGADGVVLSNHGGRQLDTSATGISTLLEIRKHAPFLLRPEYRIPHGPSKELIKNPDLLVPTTPINEKPLDRKFSIFVDGGIWRGTDVVKALCLGAEAVGVGRGFLFAQTVGGVDGTIHAVKIFESEIQLAMRLLGVNKLSDLRPSMVEIVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L565</accession>
    <name>A0AAJ8L565_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_103478</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058873.1">
        <property type="nucleotide sequence ID" value="XM_070202772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L565"/>
    <dbReference type="GeneID" id="30169887"/>
    <dbReference type="KEGG" id="kpin:30169887"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF20">
        <property type="entry name" value="PRO1A C6 ZINK-FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="161"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="75"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="190"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="123"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="247"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC69536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="769" mass="83309" checksum="2BAB2DC295FE45A4" modified="2024-07-24" version="1">MKSHPPPDPRYPYANLLQPIPLDIHSQHHASSSTGQATATLYQPASTSSTTPVSAYFPNSNLLDVTTQDQVDISNAQSSSMKVNSSSDSYSNPTKADILRRHSISRSYWDDPSPDQESLVASAPNSAKNSPISGNQGNDAPKPSGRSGQKRRQKYTRTRTGCLCCRARRIKCDEGRPSCKRCIIAKKECQYPDPGEGEEKKPSGKSKHGSRGNSDASESEKDDRPVAKRRRSDAGKGKPSPGAPYSSPDNANGANSAPTGETAWEASFVNPTANSNGISTSNGNYDSGLAIGTGLASSGEQYLAGQIGKQEWATSEGGGAPMLTTPNFLLPWFPTAEERSLILHYCANAASLMMAIPSGLNPMLAINLPLALDSPRGLNPSADALRVALLGTGAIHQAFLLARSGVANHQTAAMFQYASTLRDTGKEMVRRAVRDGNGAMTDAALGASTALGTIDIFFGGSGWMDNFNLAKEMVALRGGPAEMLKNSEPRKLTDGVTMSPARLMLEILAIYETFSCLTTGKEPDLISDRWESWWLEASRSTYEEHSVEKQFGMSRIMVLLFARVTRLLARVSRSNVLITESPPSSLAITDPTSTSFGSSNSLLDSLARGLTAEKDLDPLVIEARQLNRDVDAWIDSLQLSTLEHERVQVGNRAYAYAMKILLLTMVFRYPREDIRVQNAAQQVLQHCSWSTAALGMSIDLTWPAIIAGSCVNGASRQWVLTLLEGFKSQCCFDIETANRIITEVWRRADSGESRADWKNVCDDLGLQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L5F1</accession>
    <name>A0AAJ8L5F1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I206_104881</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012925.2">
        <property type="nucleotide sequence ID" value="XM_019154185.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L5F1"/>
    <dbReference type="GeneID" id="30170790"/>
    <dbReference type="KEGG" id="kpin:30170790"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF187">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0915">Sodium</keyword>
    <keyword evidence="8 9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="117"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="342"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="12">
        <location>
            <begin position="40"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="502"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="625"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="729"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="536"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="564"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="625"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="732"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="780"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC70929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="790" mass="86745" checksum="C3541F13C455F8C9" modified="2024-07-24" version="1">MSSGGTTPILNPPAEVINPADEEFYASWGLCILCLLLIGALITSYYLQIKRIRAVHETVVSIFAGMVVGLIIRLSPGHMIREMLSFKHTFFFNALLPPIILNSGYELKQENFFRNFGVILTFAFLGTFITAVGIGVLCYIWSFLGLEGLKFTLLECLIFGSTLSATDPVTILAIFNTAKVDPKLYSIIFGESILNDAVSIVMYETLSQFHGEDIYLSSLFHGVGIFLFSFLVSMALGVAFGLACSLGLKHSHLATYPHIESCIVALVAYTSYFFSNGIAMSGIVSLLFCGITLKHYAYHTMSKRTQKTTKYMFAVLAQLSENFIFIYLGLNLFTQDVQVFKPLFILVSAIAVMASRYAAVFPLSELINWVYHTRGQRYEELPHSYQMMLFWAGLRGAVGVALAAGITGDNADALRTTILVVVVLTVIIFGGTTARMLEVLGIRVGVEDEDASSDDEAEGWTSYNGNLALSMGPGSRRYAGSNGRLSYAAGEYDDGEIDLHSPDESPYIHGQGQKSFNLKRPSQSRSRRVSMGGRSTFGTNNSRSGFSTNSDSDEYNEEVLPSANDLNPNSQTIGNSYDPENLEEGITSSGIGSIRPGMIFKDGQWFTALDERYLLPLFSNSVTARRHHAKKQTRKVSSGLLDRERERISGNESGNGTPRGGSLDINRERIGEEDFAYDGESENGKLKSGLPRTFSGSVTDFFFAKADPSSSSTNQSSSNLPLPLEERNRLIGSNNSNNNNGNGSNSATNVNNNNNNKNKNQEEEGWIWTRPNSHSREGSRSSTPKFTKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L6E5</accession>
    <name>A0AAJ8L6E5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ARID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_104183</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059016.1">
        <property type="nucleotide sequence ID" value="XM_070202915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L6E5"/>
    <dbReference type="GeneID" id="30172611"/>
    <dbReference type="KEGG" id="kpin:30172611"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ARID" evidence="2">
        <location>
            <begin position="367"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="535"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC70233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1199" mass="130898" checksum="7A9729BFA44128F7" modified="2024-07-24" version="1">MTMSTPNTSSLPLPNNNIGRVSPLDPNLAQPSPSFGPNSFTGQPQLGAPGGPSNYPRPPPPHTNTAANTNGIRQQSIAGPSRPPPHQQPTNQFQQQYAALSGLPGQQQNGSPSFNNADPSIHARLLLAAQQQAQASAAANGANGSSNQRPPGMPDLATMANNMPGNREAIMKQLQALQTSQAQRARHALAQSQSGNHASAAIGTPAQPSAPSPAVISAPSPAGSSSQQAQFSQPQPIQSAQPIQDGTEQTFQQNSNLMQQTAPNMSNGTNFNVPQGGQIPQQQKDFLLAQGEKMRAAQQLQIQRQQQQQQQQSSIPQNGQSNQQNQPSQTTQFGQLAMPTNSTPQPPSAIGRPPNQPQSVRPQMNAAASRQSFLQSLAAFYKNFNQPLPQAIFNGERDGQFKVGGVWVDVVELMMTTMRVNGGILTLMNQGPDHPFWRTIIQGKNIPVPLPEPMLMPKPMNADPNAPQQPTTDPMQYIVNAYMAWLQPFEQQVQRQRNQVTQRQAMAIGRPPNQQPGMPQTPVNGILPGQQQFAMPSPVGSSSSMVPPSPANSMQFIPNAPSPITHAASDSKPSGRGRGRGRGRGRGRGRGGAGADASVRAVPSPIHTGPPADVSAALASVSTPESSQKRKREKKDKTTLSAENSTPSTPSSAQKALPAPPEPLERPPTPKRARYKVEYRPIHKAQHDLGGWDRNMVASTFAKNSLNQGTRSIHDLAIVDMEGVLMSLRSRLPHELGYAISILSMLSMAHPEENVKGLPLFHLSEIYQEILDLIAELTFGEEGYDAWETKRQDADLRKADQVNGRSLTESKTDLNRLTFLELEQLGRDFDFTFDDEEYLDDSRQFRDSTGGQTDIILACLNLLRNFSMTAENFEVMTRTPQLFELLANVTDGGLCRLPGEKYNPNDATKSNKPFSILELARIRRDAVSILTNLGTQINLKSVSTKSTVAIFRLLSSFLNCGFDSLAIKEPVYGPSTLIPLTEVKPPVNHSLNRALEAFCKLSSSDSNREIIGKELNESEIIRLFESLIKLFPISKRQIESLNTIEDYLGQYECLALSLYSLIFSSKPSTRNKLRNKPGILNILIRLIISLNLKKGNYSEFKLNPFGILSRRLCEILGILNENLQPNGLIENQFNFSFNLSLTNSIQSKNNNNNKIIKSYLINFQNEIINSLINIKGIDLPAFNELEGMLWSDGGGGGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L9X3</accession>
    <name>A0AAJ8L9X3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_106247</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059379.1">
        <property type="nucleotide sequence ID" value="XM_070203278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L9X3"/>
    <dbReference type="GeneID" id="30173442"/>
    <dbReference type="KEGG" id="kpin:30173442"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="275"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="601"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="275"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC72285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="658" mass="72455" checksum="2572E16D1DB80D37" modified="2024-07-24" version="1">MSDTSGWIENSKGLVVDTAQIIARSGHYGLSDTVVRNAGIAANVAAAFSLATTLGFLSCSIWIYSYSNCRHTLDRISFRLLVIAMFWEFWYSFNFLLLFINDTIYLPGHSLGPKHCTAGVYFLVSAMSVVDFLIMFIALNLFLTINMGINPVQFHLERWYIGISLLLGYMIPLASAIKEHFGWDYALGTCWINGSGNHTRLKYLIEGIYITPIITCTISTICVTAVLIVLFRQGKATSKALFGGIGGKQEISSDEEDIGCGLMIGNLSLGPLSASSGSGSGSDQRSSSLNLMSNSSGSPNSNTTITTTTTNGDLEKDEGEKVKVKYGIPILWKLKDEMNNFAHGKGWRTSKEIHSKQGESYFNSLSDKFLGIAIKIAWYPITLLFVNAILMIGDLVIAARGGAKSQKTIWLYCVYYFFYGGRGICIAGLAIIIDPSLVRGMKAAWRERKSRKNQDILPAITQSSPLESTLSPALHGRTQLSTTLNSSPSNVGQTVSMPIMRRGSSDRSFDFASALAYIPKPAQASQRNFIQNPTATLPVLELDESYLNQELDTAILDNPSPQEIGVPTDQRSLMRSSTLTSISTAKKTVLSFIPTPTAPTSTYRPVIGGGGGGGRTKMRVREQKSLDPEILRRREEQRRRQERVKEIKKKFEEVQKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LA15</accession>
    <name>A0AAJ8LA15_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein HIR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I206_105819</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC71860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059297.1">
        <property type="nucleotide sequence ID" value="XM_070203196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LA15"/>
    <dbReference type="GeneID" id="30173008"/>
    <dbReference type="KEGG" id="kpin:30173008"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000417">
        <property type="term" value="C:HIR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000921">
        <property type="entry name" value="Protein HIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055410">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031120">
        <property type="entry name" value="HIR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011494">
        <property type="entry name" value="HIRA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831">
        <property type="entry name" value="MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831:SF0">
        <property type="entry name" value="PROTEIN HIRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24105">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07569">
        <property type="entry name" value="Hira"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 10 11" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="14">
        <location>
            <begin position="19"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="69"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="127"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="169"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Protein HIRA-like C-terminal" evidence="13">
        <location>
            <begin position="618"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="409"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF24105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WWC71860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="865" mass="94642" checksum="7A272F436273F38D" modified="2024-07-24" version="1">MRVTKPSWVEHSVGEKKGRCPIYSISVHPDSTRIATGGLDNKVKIWSTLPILDEGAEKDEANHKLLCTMAAHTGPVLSVRWAHHGRFLATGSDDTVCMIWGIDPEGAGRLWGSEEVNHENWKALTRLVGHVADVVDLAWSRDDSMLASVGLDSKVWIWDGNTFERLRKLDLHQGFVKGVCWDPVGNYLATQSDDKTVKIWNTEDWSLVQSVSQPFETSPQSTFFRRLSWSPDGAFIAASNAMNGPVFVAAVIDREGWNSDISFVGHENTIQVAAFNPRLFFRKEDQPGRATASCMLALGANDFSISIWRNTLHKPLVVLKEVFGRDLLDMCWSNDGYNLYACSADGSICAVSFYPVELPELGQPELTQKILDEYEYKPKRGLTRAASIQPPLSITNSFGASAAPSSTVVNVLQPRKKNSANRRVDLSNPASTSRSIHPATNDPFAAPIQAFGGSNGHQASTAQMFEDARNAFSNNTANGDSPGRAGSKRKAVFGEDDARAVRGRLMSTAQNDNHPVEVLRAPRVSVQGGSTSSQRQLPVPQIQSVVRAALSQEEGSAYFQAQNSHSPDGLTKISFVKDNQGRWVDYASSSVLALAVTNKVCAAAHEDGSVVVYSPAGRRLSTLRLGSVIYELQASEDKLLVVTSDCQIRVIDTRSSKALISSVSISHLLDDSSTSSNIEIKQCLIQPNGVPIIITSQPAAYAYDNSLSDWITISSTHQNSSSPLTTTSTGIVGDIESMTRSLWKGKRRDNGGEWWTESMTMSHHEVRIAAATLLESKEGYQEFISAYINYLGNEGFLERAEEVLRELIGPIYKTTQPSDWADTVVGLNKRDVAKALINYLSKTNRGGELAKEYAVLLGKLSGDGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LAF3</accession>
    <name>A0AAJ8LAF3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">pectinesterase</fullName>
            <ecNumber evidence="3">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_105678</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pectinesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="3"/>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059267.1">
        <property type="nucleotide sequence ID" value="XM_070203166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LAF3"/>
    <dbReference type="GeneID" id="30171789"/>
    <dbReference type="KEGG" id="kpin:30171789"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321">
        <property type="entry name" value="ACYL-COA THIOESTER HYDROLASE YBHC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321:SF137">
        <property type="entry name" value="PECTIN METHYL ESTERASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042490143" description="pectinesterase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase catalytic" evidence="7">
        <location>
            <begin position="180"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC71720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="395" mass="43122" checksum="F002E20BDC3D6130" modified="2024-07-24" version="1">MKFIFQFIIISFSSLIFVLSNTFKECQKPKNQGNQLEGCPNGTLYVSQNDPQAEFGTIQSAVESLIDDHSNQYILVGSGSYHEVVNVTRKGPLTIMGVTSSPSDYTANTVHLFNSSYINQTTQNAFQDNADAVVLTISPSRNASLVGSGPTGAPLQPLFGNIDFRLYNIDIANRATVNGFEYTSGDTGPSAALFVSYANASFYQCTFASYQDTLYVGRNASSIFVGGEVVGSTDFIYGFGTAYFENTTLSSRNTGGGLVAWKGSEEFYGPDTFGAYFNNSRVVKAADANTTLNLTGTRALGRPWNNQSRVVFMNTYMSDIVLPQGFIEWSPSDPRVFPNVTHFIESGSYGPGWNPSARNYSVESVISPEEAQSKYSVSAVFGEFPNWVDSVYVYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LAL4</accession>
    <name>A0AAJ8LAL4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">nicotinamidase</fullName>
            <ecNumber evidence="6">3.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Nicotinamide deamidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_106400</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; nicotinate biosynthesis; nicotinate from nicotinamide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.19" evidence="6"/>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059412.1">
        <property type="nucleotide sequence ID" value="XM_070203311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LAL4"/>
    <dbReference type="GeneID" id="30175573"/>
    <dbReference type="KEGG" id="kpin:30175573"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008936">
        <property type="term" value="F:nicotinamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019363">
        <property type="term" value="P:pyridine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052347">
        <property type="entry name" value="Isochorismatase_Nicotinamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080:SF2">
        <property type="entry name" value="LD05707P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080">
        <property type="entry name" value="PYRAZINAMIDASE/NICOTINAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="8">
        <location>
            <begin position="4"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC72438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="251" mass="27912" checksum="80E6BBC491179E30" modified="2024-07-24" version="1">MSKTAFLIIDVQYDFLPPSGSLAVPDGEAILPVIHDLLDQSKWDWSVIVASQDYHPQNHISFASNHSPHKPFEKMTLTDARGTSYEQALWPDHCIQDTRGTQLEAKLVEDLKTWGDKVKLARKGTHEKLEAYSAFEGYITSFQTPDEPTFEQTSADPGKTVLPKQSPLTIYLREKGIEKVVIVGLATDFCVLQTALSAISASFDTLVLGPGIRGISPEDTHKAMQRIESLGGTVVDKGKENWTDIVKQWMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LBB6</accession>
    <name>A0AAJ8LBB6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dystroglycan-type cadherin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_107636</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059658.1">
        <property type="nucleotide sequence ID" value="XM_070203557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LBB6"/>
    <dbReference type="GeneID" id="30174340"/>
    <dbReference type="KEGG" id="kpin:30174340"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006644">
        <property type="entry name" value="Cadg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF26">
        <property type="entry name" value="AXIAL BUDDING PATTERN PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05345">
        <property type="entry name" value="He_PIG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00736">
        <property type="entry name" value="CADG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042523580" description="Dystroglycan-type cadherin-like domain-containing protein" evidence="7">
        <location>
            <begin position="20"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Dystroglycan-type cadherin-like" evidence="8">
        <location>
            <begin position="22"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Dystroglycan-type cadherin-like" evidence="8">
        <location>
            <begin position="144"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="498"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="544"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="677"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="719"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="810"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="910"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="553"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="733"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="749"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="781"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="812"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="914"/>
            <end position="935"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
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            <dbReference type="SMART" id="SM00736"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="WWC73664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1115" mass="120205" checksum="B01C18670111E19D" modified="2024-07-24" version="1">MLIIPSLLALVASISTIRAAPTLNFPLNQQQPGVARVNQEFVYELLPATFNSTSSTNLTYTTSTLPTWLSWDSPSLAFHGTPALADEGEQDITLTATDGSGSTTSTFRLIVSNYSVPAVHQSFYTQISQPNLHAISSATIMPGGTGVTIPPYWSFSLGFQTDTFRISREDPNNGQLYYAVHVRGTVGLPSWLKFDNETVTFTGVAPAEGSYTVVATGTDFWGYTGAQTSFTIEVGQGQAIEMARNQNLTNAQTMAKNTLNQKIDLSGVTIDGNAVATGDVEINLGSDDYPWLSIDSSTDSLTGTVPDQYQNGTFASISVPVDIRSTNTSNTLYLTTWLGIDILPYFFSTFSLPNATATLGQDFNFDLSNYLVNKTATVNATVNPSDAASWLSFNPKNMSLHGTAPSTLSYNKIDVIFEATIGQLAATSTLNVEIPQVSQTTTHTGTAAVPTSGGSGSPGISKGAKIAMGVCLGLLLLVTIILILFFCCCRRRRKNKGAAKRDDDNDSFVATSPVTVNDPFRRSGSLDPPRNLLGEIARFSGLNLKSGDHNEKNTPLSPASLSTDATMVQDRPTRLDGLKGIFGWNNKEELNSENEKPAILSPQIPSDSRSFIGYPDVIGVNDPVNRPSQDASSFTQSFISESSRASWQSQESFHWSSIDGEGEDEVASLGAVGGNRISTASSIPRPRPNFTPRYPRHQNPSVLARMVDLDDVGSQASFSEFHSSQEGNHRDSLQSGSNFESGSGTGFDGSSNSMMASGSMFESNPGSSFPAGPSGLSRFGDSGKFKSQHDFTDDEDAFSVEGPAVVAMAERQSFETRRPQRQDSRSHPRLKESRSRHGTGDLGMPPSEQSREAIPEEEQNRISGMFSDADHDQARRSTVYAPSEGGIQENPGLGYPNSAIYFGSQNGDVEPSEGYTSQRNSILPQRSENRGSSTIKVIPSKGVSPLSPALPQVGSFIRHRRTNTGSAGATNAMMKSPPSSSNGANDGRIIAIANETFSIHPQINPPPTVSLSAATWSSNPPSTYRAEIENGGNLPNWLHFDSRELELWGVPPLRVTGDVTIIRIIERLPRDNRRSDPMSFGYEPPQEREVGRITIEVSDKMRSPQFALEGSPHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LBS4</accession>
    <name>A0AAJ8LBS4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ubiquitinyl hydrolase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_107224</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144528">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_070203482.1"/>
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    <dbReference type="GeneID" id="30173601"/>
    <dbReference type="KEGG" id="kpin:30173601"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF937">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="7">
        <location>
            <begin position="27"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="6">
        <location>
            <begin position="226"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="518"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="520"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC73258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="665" mass="71868" checksum="A45A152807BF5214" modified="2024-07-24" version="1">MSNVVTAAPSTGSTPTATNIFARPDTSICSHLSSLLESANKATQDYQLPQDGMNGSVPAPAPERKKHEVEKRFTETVRWGAVAEGAKRRKTSSPACHSCSTTLTRPWACLTCPYIGCLPFIGVSSSSTSKDCMRSHWQQSNGSCGFAVDPSSGAIYCSSCSDTIYPDQFESIFRIVRIRTEEMHDKSREPGVVGGGRGRGRGPWKAWNPTNMVKIQESEVEKSSCRGLRPLLNLSQTCFLSAILQSLIHNPLLKAYFLSDKHNRHVCPNGSRGLSVGKPFLGAEAPNGAPGIDREKGCMCCEMDRAFEEFYNEDKSPYGPITMLYAMWHASAELEGYGQQDAHSFFLAALDQIHAHAKGQLSSCNCIAHQTFSGQLLSSVTCSSCSHTSSTIDPILDVQLDFPYSPLAGSSSATIASNTSTSSSEGISAGNQLTLAGLLRRFCANENIGETDGSGKGFECSKCGGGPGTYATKNLAIKKLAPVLSFQLKRFAHMTSSSSKIESHVKFPSSLNMRPYVDSPSPTSFASNQSVSEDVKPNIDDETQPAEDNVLPDSLFMYDLFAVVTHEGKLDNGHYWADVREGEEWWHCDDDKVTPTTLSSVLSQKAYMLFYVKRSLAYAQPMSKLLSTTAPSASTNTANTTTNNVPLPPVLNTVNSSGNVSTITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LD96</accession>
    <name>A0AAJ8LD96_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_107488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059631.1">
        <property type="nucleotide sequence ID" value="XM_070203530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LD96"/>
    <dbReference type="GeneID" id="30174185"/>
    <dbReference type="KEGG" id="kpin:30174185"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC73517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="190" mass="22888" checksum="D4311DA5B13904F2" modified="2024-07-24" version="1">MPYIDRRYAQQIVPYDRNHRGLYLAPGQGKNVPEKVIVCYRPNENDTDSWTSSSDYTQRRVYRNRYEYSSSDESWVLGDSYTSNSSTDSRDLPIAYQLYNLLQGMRNKLYGERYHRNSRRPRRYIDASSDDTWDATSSEWSSEGSSDYWNKTSSEDTHRPRYKTYERYHGRRRRRAHRREPGLLEKFFGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MLH9</accession>
    <name>A0AAJ8MLH9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GP-PDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_100449</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058305.1">
        <property type="nucleotide sequence ID" value="XM_070202204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MLH9"/>
    <dbReference type="GeneID" id="30169249"/>
    <dbReference type="KEGG" id="kpin:30169249"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08567">
        <property type="entry name" value="GDPD_SpGDE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46211:SF14">
        <property type="entry name" value="GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46211">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042539038" description="GP-PDE domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="2">
        <location>
            <begin position="30"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC66546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="389" mass="43019" checksum="F37D238B295CB227" modified="2024-07-24" version="1">MRSVALLSLFLGVGTATASPLKRWVYSKYFDLQGHRGGRGEAIENTLPAFAWGLIDGVTSLEMDLGLTKDGHLIVWHDESIDPTKCIDTKAVIENDPMFPYVGKYVANLTLAQVKTLDCGSLRLDGFPLQEVYAGTKVSTLSEMFDFVSCATDEEVLFNIETKIDGDQRNLTRSVEDFVKAIGDIYSQYNIWDRVTHQSFEWQAIKLSKELYPQLRTSALCDDSTIYKRLDGGKAGNLTIHGKGPSNWLAGIDIDTFPGNTVGERVARAAASIKADFLSPVVTSYASKVGADDPNEKGWIAFTNQTMVDTAHSLGLQVKPWTANRKSIHEYLLSIGVDGIITDYPHELRRLLEHKGTYPLAPKGDVDRIMGCLAKHNQYTNKKGDGKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MMK3</accession>
    <name>A0AAJ8MMK3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_101598</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008750.2">
        <property type="nucleotide sequence ID" value="XM_019158137.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MMK3"/>
    <dbReference type="GeneID" id="30174801"/>
    <dbReference type="KEGG" id="kpin:30174801"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="406"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="436"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC67686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="495" mass="53759" checksum="48A4634839761C61" modified="2024-07-24" version="1">MSFMADNPSFAPHPFDTETKFYPRSNPNFILPSPPSSDNGLLDFDIESFTHCSPHSVLLDPLPINDKAETPNHSIDFDLNQAVDLSPVASASTPTSTTLVSPKSSDLEISSIPQLPILSSITNSDADTAEALSSHHLQRYLHYKALAARAEADRAVAQRQSLDDQFDTLFATCDNLDILMPSGPGDYDQLKANGNDNMLAYQPQSIASSAYYGMGQQMADWTTPNSTFTYQPQSAQAALQAQAQAHLQAADVARVQAQQQRAIANQTYYVPSNSRSSFEAAPQQFTSFARPAMSTLSSNSPSYPSTPTYAGVPSFTPIPMSKTSTSASMPSFISVSQDPSPAVRRAISNNGSAHEGEDELADYSPTSRSGLEELKPMIPGMPIPNAHGGGRGYVPGQTPDDPKKRHKCQICGRAFARAFNLKSHIQTHNPLRPKPYMCPHTSCKRGFSRLHDLERHRQGIHSDGPLVEAKRQGVSPAIARAQNKMQKRAESGSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MMT6</accession>
    <name>A0AAJ8MMT6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Poly(A) polymerase</fullName>
            <ecNumber evidence="11">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">I206_101307</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Polymerase that creates the 3'-poly(A) tail of mRNA's.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 2 magnesium ions. Also active with manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="11"/>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058463.1">
        <property type="nucleotide sequence ID" value="XM_070202362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MMT6"/>
    <dbReference type="GeneID" id="30168386"/>
    <dbReference type="KEGG" id="kpin:30168386"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000002">
        <property type="entry name" value="Poly(A) polymerase alpha, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000001">
        <property type="entry name" value="Putative poly(A) polymerase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048840">
        <property type="entry name" value="PolA_pol_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007010">
        <property type="entry name" value="PolA_pol_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014492">
        <property type="entry name" value="PolyA_polymerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20750">
        <property type="entry name" value="PAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04926">
        <property type="entry name" value="PAP_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018425">
        <property type="entry name" value="PolyA_polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="PAP/Archaeal CCA-adding enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) polymerase nucleotidyltransferase" evidence="17">
        <location>
            <begin position="11"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase central" evidence="16">
        <location>
            <begin position="209"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase RNA-binding" evidence="15">
        <location>
            <begin position="359"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="514"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="641"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="553"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="578"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="103"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="236"/>
            <end position="237"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR018425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF20750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="WWC67399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="667" mass="73052" checksum="BB43322860BBD171" modified="2024-07-24" version="1">MSSQQEIRYLGVTAPISTDRPKEDDVKSSEALMGDLVALNQFESEQERKVRERLLSNIAQLVSKFVHDVSIKAGMSEKVATEAGGRIYTSGSYRLGVHGPGSDIDTICVCPRHIYKEHFFGEFQDMLRAWPAVTEISAVPSAFVPVMKTVISGVEVDLLFARVNLAEAGDKLDIEKDEILRGVDDASQRSLNGPRVTDMILNLVPDVATFRTALRTIRLWAKRRGIYSNVLGFPGGVAWALLTARICQLYPTAAPATIVGKFFPIYYQWGWPQPVILKKIETGPSNMQHSVWNPKLDRRDMAHRMPVITPAYPSMCSTHNITASTMSIIKKEMLRAMQITDEIIKNPGSTWISLFERADFFSMYKTYVHVVASASTSEGIKDWSGMVESRIRTLVQDLENTDNIILAHPQVGGISNVFYCLSEEEQAVASQGEVPPELMNRKETDIEGKEGARKIWTKNFFIGLEIEKKPKDGQGSRVLNLFYPSKRFCAACQGWEKYNEMEMSVILRPAKRSDLPPYCFPDGQPKSKKKTKRGQQNGTNDIGLGDASEEHSQGPSKRSKATPSDESSSISYPVTNETSNSSIAASPIPSTVPLPNGADPVPPSILNGNSNAALPLPPPGIENLPPLSATSLSGFATAANGVVHDGHSGKNTDGLVVLNGAPQTASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MQ03</accession>
    <name>A0AAJ8MQ03_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_105599</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059257.1">
        <property type="nucleotide sequence ID" value="XM_070203156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MQ03"/>
    <dbReference type="GeneID" id="30171870"/>
    <dbReference type="KEGG" id="kpin:30171870"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000013">
        <property type="entry name" value="Voltage-gated chloride channel (ClcA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF6">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9" id="KW-0868">Chloride</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="517"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="691"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="726"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="765"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="806"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="861"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="888"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="928"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="953"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="1153"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="347"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="548"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="169"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="205"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="349"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="548"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="567"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC71641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1211" mass="131978" checksum="30392FF3E9935A69" modified="2024-07-24" version="1">MSQSREEEEQRMSTSASTTHSTHTIKPPRPPSIASLRHNRFYGSSSSSSAGAGPSSRSSHSHSRRQSLDIAETQPPSPITYFPNPSTFQSNSASYPQPPISSTSNSISTSPKNSTFSMSNSVVSLPEESEFEGPTPKMSLVNLDSAASSPRMTRGGGNSQLEQRRRSSVAPSTSQGMRQFSTPVNGYGSTHTSNSNLGLGLGRTPSLSTLNNPNQDATLSSPRRISTSRVPPGPSTNRFTVTPPQGLLNLPTHEAYYSASQPGTATTSRFRDKDLHQSHPLPHSAIPYSNQLATQMTSNSNSHRRHLSVNSIIHSPLFPGRHSLPHSPTGSVMRKIKRTASTIGMGFGRPDHYDDDASRGKGGEDEMLEDDEGERANGTRVWYSSYVTIDWIHDAIKDSSRVRRLRHAAHRSIRGKLANSWDRIQGWLVVTIVGVLSAVIAFFIIRTEMALFDLKEGFCGSSWGTAKRFCCAPHHPSGRGDAGDEENCGDWVEWGEFFAPHQRGGPEGQWIWGGPEFIAYAVVALCLATLASFLTVYLTSAAHHTTSKDSTFLTTPTEHNDNKSKQPKQIPTMNNGENSNERQPLLEGIANEPITPITEAFPPTEPPRKIMYYAAGSGIPEIKTILSGFVIHGYLGGWTLITKSVGLALSVASGLSLGKEGPLVHISSCVGNIVSRLFLKFECNEAKRREILSAACAAGVAVAFGAPVGGVLFSLEEVSYYFPPKVMWRSFWCAAVAAITLKSLNPFGNGSLVLFNVTYTKEYHYWEYVIFVFLGVFGGLYGAIFARLNIIWSRQVRGGTWLKKHPIFEVALVTILTTVISFLNPYTRMGGTELVASLFEECQPSSSSSFCVNHPHEIAPVIWTIGTALLIKGALTIITFGIKLPAGIFIPSLVVGACFGRIVGLTMEYIEYSYPTLGIFDVCKETDCIVPGLYAMVGAAATLAGVTRTTVSLAVIMFELTSTLNYVVPVMLGVLIAKTVADGLEKKGIYDLVIDLNQLPYLDQKHEYLWGSRRASSVADKSVPILRADKQHTVRSLTGKLLESVRLGMTDTGFPILVKEVTANGGNPSSGMGPDAAMTSGRERSCLRVIGFLGMNELEHALSELSDEPDATLNLMPDDATSHRRRSSAMSIFSFADSYADGQWSPYDLSRYIDRAPITVQIHSPLELVQQLFVKLGARQIIVTNSRGVFQGMVTKKNWLNFLGELEEDGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MQR6</accession>
    <name>A0AAJ8MQR6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_104365</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the prohibitin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059038.1">
        <property type="nucleotide sequence ID" value="XM_070202937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MQR6"/>
    <dbReference type="GeneID" id="30172425"/>
    <dbReference type="KEGG" id="kpin:30172425"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF1">
        <property type="entry name" value="PROHIBITIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="7">
        <location>
            <begin position="65"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC70414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="322" mass="34863" checksum="272CCF44937FE272" modified="2024-07-24" version="1">MNRSGGEAFAKLAQQLNRARLQASGGGRGGSGGSGGQFPGSPKGFLAGGGAIAVLLAGGIAVNYSIFNVDGGHRAIKYSRVQGIKPDIYPEGTHLVLPWLESPIIYDVRAKPRNIASLTGTKDLQMVNITCRVLSRPSVNDLPTIYRELGTDYDERVLPSIVNEVLKSVVAQFNASQLITQREMVSRLVRENLTRRARRFNLILDDVSITHVAFSPEFTHAVEAKQVAQQIAQRAAFLVDQAIQEKQSIIVRAQGEARSAELIGEAVRTNKGFLQLRRLEAAREIAGTLAQSGNKVMLDAKSLLLNVADEDVINSSSFSSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MRG0</accession>
    <name>A0AAJ8MRG0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_104895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012939.2">
        <property type="nucleotide sequence ID" value="XM_019154199.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MRG0"/>
    <dbReference type="GeneID" id="30170804"/>
    <dbReference type="KEGG" id="kpin:30170804"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="40"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC70943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="407" mass="45261" checksum="9157C29D8A74FDBE" modified="2024-07-24" version="1">MILRSMKIAAAKRGVRGVHDFVRGSTGGGTYKVPLNSPKIVGVYASRGSREYQEDAATVGSLQLPPDELQTSLRKLKKPYEWDPISSGSDFLAGQVAAFGIFDGHGGTEVSTYLKNNLFKEIEDAKLSDIEELVDWTKDRHGGYFRRWRGGALSRWTKYASNGSKPPEGENMTIEERLNIAFLKADKHILENIEKSRRCGSTSSVVLLHSLDSPGQPYWSAKRLSLTVAHCGDTRALLCHQPTGEVIPLTEKHHAEARVEASRLRRMGAELLVSDSFGESRWMGVVENTRGFGDGEWKPSGVTVEPEVTTRIIDGQEHSYLILLTDGLTSLLSDQELVDLIRKSFDPTRAAKTIVHFAEDLGASDNCTAIVVPLGGWGNVGGEDTTKERREWRRRRFGEMNTRMQRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HSB7</accession>
    <name>A0A1B9HSB7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_07831</name>
        <name evidence="6" type="ORF">I206_100016</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV700119">
        <property type="protein sequence ID" value="OCF46161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007380.1">
        <property type="nucleotide sequence ID" value="XM_019159516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HSB7"/>
    <dbReference type="STRING" id="1296096.A0A1B9HSB7"/>
    <dbReference type="GeneID" id="30176200"/>
    <dbReference type="KEGG" id="kpin:30176200"/>
    <dbReference type="OrthoDB" id="4934715at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF89">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="145"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="608"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="608"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF46161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC66116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="685" mass="77554" checksum="4893BDF4B47A4D45" modified="2016-11-02" version="1">MIRDRLPSPTSSNDHTERRQVRVKRSRAVLVSHVDHASRQRQRIDAPMITGEDKARAVIPTSTDQSINAGPGPTTLESRLSRLEDRLHGVDILLSKDQNPENRRRSDLYKRAVDDDTEWSFLLSQLPPRSTVYRLIRQYFILDTLNRYTHAPSYEQHLASLYANNSDHVNMQLSTEQAPYLASLCLAMVIGSKADQEGSSEEDNRNLCELVDRLSYLHKRFSHFSAKFVSSQPQSADPKIAYYHLHSLMLRLQEAIYDSSSSLPETWFEMGEVFHAALFLRFHQDPDELSIVLSPFWKEMRRRMWYLIYCGEKITTSKLVLPSMLPLATVRRPVLVPDDELREDITQSQLDDRTFVNEFMQSNGATMADLTPPNMPIFSNRKSTATEWAFIDAKISNTQLLCELSRILPQSSQNIHPPDIQVIDNIVDRFDDKRPGHFSLDLLANAQSRDSPLTAPDRPAWICAQACVQNIGIATAVLQAYQPYLSIPTSSYDVAKIVQHALDRSLEAAHRLLVAAEVYVWHITFRWPEGKCLFSWNLGSRLFSAGALVALAAIRDGKEHPSWRGWMGDLKAAEGLLRVVSDHTSKDGQGRGGSADLKALRILRQLSDQATGQTSSSAQSTDSATPVMRNSYGQERIFDPYTSHEMRNISVLSNDPSSDKFEIPETFTLEDLEALLTQVYGKPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HSD7</accession>
    <name>A0A1B9HSD7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">OPT family small oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_07851</name>
        <name evidence="12" type="ORF">I206_100036</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700119">
        <property type="protein sequence ID" value="OCF46181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007400.1">
        <property type="nucleotide sequence ID" value="XM_019159536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HSD7"/>
    <dbReference type="GeneID" id="30176220"/>
    <dbReference type="KEGG" id="kpin:30176220"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="409"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="556"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="585"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="666"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="732"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="782"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="811"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCF46181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC66136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="878" mass="99365" checksum="7403010FBE91D03C" modified="2016-11-02" version="1">MAVDENEYGITPVVDSTPSTLMYGDEKKTSLEGEADVKGGHHVAPILQSEETIEEVTGALEVTQQDLIDAEQKLETMSLERCRRIMVQVLELHQHDQNFPTSSLDRMKFFLHDDDVIANPDKHTELITEMKLEALLVTENSPYAEVRANVEPYDSDVPSFTFRVWVLGILFSGIGAFINELFSIRNPSVYVTANVAQLLAYPFGRLMATLPDKRFRLFGKEHSLNPGKFNKKEHMLITIMATVAYNTPYTNYTVFVQALPVYFNQPYAYNFGYQILCGLGSNFCGYGLAGLCRRFLVYPSFCVWPTSLVTIALNRAFHSETNEPVRGPFNRMYYWSREKFFLIMFLAMFVYWWFPGFIFQALSYFNWLSWIAPNAVTLNNITGAINGLGVNPIPTFDFNLLTVQGWVPLVLPAFTILNMFFGMIIAFFMIVGTYFTNAWNTGYLPINSNKLFANDGTRYQVLNILNDDGQFDNDLYQGYSEPWMCAGNLIIYFWFFAIYTATISYTWLYHRHDIALGFRGLFKSLKKKRDDMEEGDDLAEDIHYRLMKKYPEVPEWWYLCVLLVAAGLGMAAIGAWPTYSTPATVIFGLIMGAICVIPVGMITAVTGVQVTMNVLAEFIGGAFAQGNAIQMNFFKMYGYIVTAQTIYFSNDLKLAHYAKIPPKHTFAAQMIATLVSTLVCTAVFNFQLGFANVCTANASFGFTCPGQNTFFTASVFWGTLSAKRLFGPGRRYNALLIGFPVGFVLPFIGYGLQKAFPRQKWLRQLHPVMICAGGLLWSPYNFANYWPVVPLTCLSWLYIKKRYLAFWSKYNYVLAAAWMTGIALAAIVIFFALEIPAVELNWWGNTVSYEGCEGAACRRLPIPDVGYFGVPPNSSRFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HSN9</accession>
    <name>A0A1B9HSN9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">tRNA pseudouridine(38-40) synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_07769</name>
        <name evidence="7" type="ORF">I206_103817</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700118">
        <property type="protein sequence ID" value="OCF46289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC69874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007508.1">
        <property type="nucleotide sequence ID" value="XM_019159456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HSN9"/>
    <dbReference type="STRING" id="1296096.A0A1B9HSN9"/>
    <dbReference type="GeneID" id="30176138"/>
    <dbReference type="KEGG" id="kpin:30176138"/>
    <dbReference type="OrthoDB" id="25767at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF5">
        <property type="entry name" value="TRNA PSEUDOURIDINE(38_39) SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="5">
        <location>
            <begin position="288"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="22"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="195"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="525"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="207"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCF46289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC69874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="547" mass="62775" checksum="F3DE31B0ED1645FC" modified="2016-11-02" version="1">MAHLASLSKEELIAKIQFLENAAKSKQPSSEDSIQSTEASTSMIDKDDELNRSKPILDENGKPLRKHARKAIRKNDKPFNFNSYPTRHIALMISYYGWPYCGLALQPPLPGMPNVQTVESELLKALEKTKLIEVGKGLEGCGYSRCGRTDRGVSGEGQVVNLWVRSLRTPNDGGEELPLEIGYKEPKEPINMVSKLEVDDDDDGESEESKKKLNKSKEKVDNSKISEYPYPKLLNGVLPPSIRILAWSPLKEEFDSRFSCLYRHYKYAFHLKTTPLSKPLNLELMRKASNYLIGENDHRNFCKLDGSKQINNHKRTILKAYFENEINENNEERIDENKKIIFNLIGTAFLWHQVRHIISILFLIGSELEKPEIIKDLLNVNKFPSKPLYNMGDGLPLTLHECSYEKILLDWRFSGYDGNWKNLSIEKKNELYKFAMNGRESFERNLLNLSQQAELKSWQINGSLRKLHQIYGGLNTLQKDKENQIIYPLGGGEINISHQYTKLENRHRGETPQVVNEKWRIAKGRTGLKGKKGEKENLVESVQDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HST5</accession>
    <name>A0A1B9HST5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">MICOS complex subunit MIC60</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Mitofilin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I206_07791</name>
        <name evidence="15" type="ORF">I206_103838</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MICOS complex subunit Mic60 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700118">
        <property type="protein sequence ID" value="OCF46310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC69895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007529.1">
        <property type="nucleotide sequence ID" value="XM_019159477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HST5"/>
    <dbReference type="STRING" id="1296096.A0A1B9HST5"/>
    <dbReference type="GeneID" id="30176160"/>
    <dbReference type="KEGG" id="kpin:30176160"/>
    <dbReference type="OrthoDB" id="10261039at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019133">
        <property type="entry name" value="MIC60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415:SF7">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415">
        <property type="entry name" value="MITOFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09731">
        <property type="entry name" value="Mitofilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCF46310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WWC69895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="762" mass="83511" checksum="2B6E41EFF3880638" modified="2016-11-02" version="1">MYGQLRVARSRAARSLPQRRCLATPPSTPPPGTALPPNPPTTLNSIPTRPVTIPPTTPTPGSTTLASKPLPPPSNLPPPRKPRKFFRRFIIYTTLGAVTFYSLSAFVSTKSEGYRDFFVGNFPGAEPIADFADDHGWESLGYGSVTKKAIQSYQSATGNETTTQKVERKASETKKEVINSAEKVKAKGVELKDSVIGKETTSQKIQHTASDLKDKALEATHKAEDKIKHLAHDAKEKVDQVTKDVPFNFSDGVEGIVREAEKAIGSVESSSKKALDSAENALKDAENKVEGAAHDVKEAIKPHATEYEKAVSPYQQRTRELNPTGVQPQQPTFEGKRVYDGPPLPLGHEPPPGYYIPPPAKPVKAVVEEKVEKIKQTLPLLVPKVKEFAAEEPIISQLASTIDSLTSSLSNASSTGLPSTDANGILSRAQDDLTALNKRLHDVKAAEKERLEKTVGEKTKEFEDLLKGREADWTKSEQGLKESWAKERETLVEKWRGELEGELESQRQNIEQRLRDEVVSQGIELQRRWLRSIKTQVETERGGRLAKLDNLTTSLKQLERVTIDNSAQLDDNVRLHKIWSALRAVQSKVDQGDISFDEELKALKSLSSSSNDSNEKNVIGITLEQLEKTGIPSTGVKSFGSLSSWFSGNGGVSNKIHSSSLVPKPEEASVLSHLASIGLSKLLFRPSAGKIEGNNVGAVLARAEWCLSEKDLDGATREINSLKGWPGKLAQDWLREARRKLEVQQALEVVATEATLSSLLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HSZ9</accession>
    <name>A0A1B9HSZ9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Short-chain dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_07630</name>
        <name evidence="7" type="ORF">I206_102260</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894017">
        <property type="protein sequence ID" value="OCF46396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007615.1">
        <property type="nucleotide sequence ID" value="XM_019159321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HSZ9"/>
    <dbReference type="STRING" id="1296096.A0A1B9HSZ9"/>
    <dbReference type="GeneID" id="30175999"/>
    <dbReference type="KEGG" id="kpin:30175999"/>
    <dbReference type="OrthoDB" id="3819888at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_7G04540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="236"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCF46396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC68335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="32535" checksum="1A948CBF62E6E33A" modified="2016-11-02" version="1">MSFDQNQNQFKAENLFSCKGLTAVVTGGGTGIGLMQTIALSQNGAKVFITSRNFEKLKDVAEKYGKNLNNNGGEIIPIKGDISNKNDIENLVKEIEIQSKDGINILFNNAGIAGEGSREGWENINYENPKEYSKQLLKSEFKEWDDILHTNVAGQYFTAAAFLPLLADGAKSTKGYASQIINVSSISGLMKSSSGGQFAYTSSKAALVHLSKVMAREFLPLRIRVNQIAPGIFPSEMTAGDSDSTTHKSDLSNTGKGKGLPSGRPGKEEDMAAATLYLASYAGVFVNGQFIAPDGGATVATPSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HT24</accession>
    <name>A0A1B9HT24_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein arginine methyltransferase NDUFAF7</fullName>
            <ecNumber evidence="7">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_07649</name>
        <name evidence="9" type="ORF">I206_102279</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NDUFAF7 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="7"/>
    <dbReference type="EMBL" id="KI894017">
        <property type="protein sequence ID" value="OCF46415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007634.1">
        <property type="nucleotide sequence ID" value="XM_019159340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HT24"/>
    <dbReference type="STRING" id="1296096.A0A1B9HT24"/>
    <dbReference type="GeneID" id="30176018"/>
    <dbReference type="KEGG" id="kpin:30176018"/>
    <dbReference type="OrthoDB" id="438553at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF7">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF46415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC68354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="439" mass="48574" checksum="8BDCC5CCEC58F32F" modified="2016-11-02" version="1">MSRTAFRSTLDRAIRRSSRGIAPSACRYQSTSTSSSSSVPAVKDNELAKVIRDTIRATGPIPLSRYMQFCLSHPIHGYYQKSDVFGEKGDFITSPEISQIFGELVAIWFLTRWMEVDSPTRVRIVELGPGRGTLMDDILRTLFNFPGITSAIKSIHLVENSEYLRKVQNDKISRRIEDKEVELSWNTGINEIPEADDTYTLFVAHEFFDAMPINTFEKTDMGWREVQVDNDPMHGNGLSTQTSKSGLRLSISPSPTALSTVLPASSPRFAKLSTGSRIEVSQDSFKIMRRIGELLGKGKGGCGVVVDYGGDRSYGQSFRAFKGHKIVDVFDDPGNADLTANVDFAYLRESLAGTGTSALGPISQASFLLSLGLQPRLRKLIDSASTEERKEDIRKSAQRLIDPLGMGGQYQVMGISSGEMTEEIYPFISPKKESKVLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HTJ8</accession>
    <name>A0A1B9HTJ8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_07454</name>
        <name evidence="9" type="ORF">I206_106655</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="protein sequence ID" value="OCF46601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Chromosome 9"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HTQ9</accession>
    <name>A0A1B9HTQ9_9TREE</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
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        <name evidence="16" type="ORF">I206_106602</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Murphy C."/>
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                <person name="Saif S."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
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        <source>
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        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C2B_Tricalbin-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="C2C_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="5"/>
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        <property type="match status" value="5"/>
    </dbReference>
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    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="236"/>
            <end position="253"/>
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    </feature>
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            <end position="485"/>
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    </feature>
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            <end position="599"/>
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    <feature type="domain" description="C2" evidence="13">
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    </feature>
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            <end position="1001"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
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            <end position="1571"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
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            <end position="971"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCF46654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="WWC72638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1571" mass="169728" checksum="C49D17408EA6A13F" modified="2016-11-02" version="1">MPSMPGIPSLGKKLPELKAVDHAAQNGNTETNVVEGDVNDAGLGGMTNGMQSAFGKIASLDALKGAPVHTFDPDASPEQKAASKAQAKASLGLPSSATIKATLGQVGTYVPGQTKKEDLDLGGRAVTIDTSTSKSAPIPTVSLADVDRASRAEGQGAGEQDLPGAIPTGAAPSVPTYIKTGWRQVAGLGKDDKTAEESNILAAYLTEQMYGAWFHNAGIILFAILLTRFVTVFHLGWGWVVVILAFCSSYYSLSISRTRQRARDDIQRELVKTRLVTETESAEWMNSFLERFWLIYEPVLSQTIIASTDAALAGVAPAGVESIRLTTFTRESDVKPPRIDYVRTFPKTPEDIVIMDWALSFTPNDLQDITPRQAAKRVNPKVVLSIRVGKGAVSKGIPILLEDMSFTGRMRIKLKLMTNFPHIQTVDMSFIEKPTFDYVLKPLGGETFGFDINNIPGLAPFIRDQVHANLGPMMYDPNVFTIDLQQLLSGTPLDAAIGVLRITVLDARGLKAIKFGGGDPDPYTAIALGAKPAITHTKTIPSTSNPSWQETHFILLNSLADVLNFNVFDYNDHRPDNLLGTVSHELGTLSEDAEQEGIVGKILGGGKDRGELRYDLSYFPVLKPEKNPDGSLEPVPETATGIVRLTLHQAKDLDINRLYGNLSPYAKVFLGNSRKEVHKTQILKNMNQPIWESSCEFLVPEKGNSVVTIGVVDAREMATDGDLGKITVRLTDLLEARARQQDWFPLKGSKAGKLRLTAEWKPVAMTGSVAGAAAYVPPIGILRIWLKKAIDVKNVEAALGGKSDPYVRVMGNNRVLARTEVISNNLNPEWDQIVYVPVHSTRENLILELMDYQNIGKDRTLGTVEVRASDYIELDETNAQYPYKSIGKQDRRDKIKLDKANHYKGDLLYEVDFKPAVSLKGGVSFEAQKNEFEMAAKQAEQAAIDDEEGPSSSDPAGETTIVSPVSPSNGINGHKPSASIGANSTGQPSEIGHRPSQSIGNTSVLSAATAQTTLSKNDGALTPVEDVEKGVNMSIEEILASSSGVLVFQVISGQLAKKGSLEVMFDDGYWPSFTSGKARSNHPTWDQVGEGFIRELDFSRTWLRINASDENDDDDIVAEYKCETKEFLDQCIRTPSDFVLTRSDGSHRSIVTIAARFVPVNIELEARESINNMGILRVDVLSAKGLHGADRSGKSDPYVVFHLNDMKVFKSDTKKKTLSPVWNESFEVMIPSRVAAKFRFEINDWDRVGSATPIGSGVINLADLEPFESADLTLPVVSEKHGEKGSLSVRVMFQPEIIARTRQKTSTFSQAGRVVTTIGGVPLGVGKGVVHGGGAVIGGKKDKSGKEVIVEQPEPTADPSGFDIPAGQVSDPTDEVLAAGGMTGGVPGPKATTLPVGEGTAPSEPGTLAVTVVSAKDLKAGTKPYVQIKLGGKVHKTDHVKSATPEWDETFNFNVAPGTTSFNVSVYDHHTLGKDIELGLAEVDIFRHIQPAIPNADVWVELGSGNGLLKLRLDWNTGISSNNNNGIGKVRNRTPSISSSKVGAGPESSPSKFSMKSKRKSSVDKTPTLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HTZ1</accession>
    <name>A0A1B9HTZ1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_07124</name>
        <name evidence="2" type="ORF">I206_106323</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894015">
        <property type="protein sequence ID" value="OCF46737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007956.1">
        <property type="nucleotide sequence ID" value="XM_019158818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HTZ1"/>
    <dbReference type="STRING" id="1296096.A0A1B9HTZ1"/>
    <dbReference type="GeneID" id="30175493"/>
    <dbReference type="KEGG" id="kpin:30175493"/>
    <dbReference type="OrthoDB" id="432536at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053275">
        <property type="entry name" value="Agnestin_monoxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38688:SF1">
        <property type="entry name" value="FAD_NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38688">
        <property type="entry name" value="PYR_REDOX_2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCF46737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC72361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="44209" checksum="FD2BCA9996DB0956" modified="2016-11-02" version="1">MLSNTYRAIIIGAGPGGLAAVKSLLDAGITKICWIDRKFGGGRLNEMYREISSNTKVGIYLDAVESSPTCQRIIDSTPKPNAITAFEKYDRDETCQLSIAGDICKMLEKGLLEIEGVDKLVDTVEEARLEGSTWKVGLSGSSTTLLTSRLFLCTGSHPIIPSFHKSYNPDLEILDLDKCMIKSNLHSLFPKNKSSIVGVIGNSHSGILVIKNLFEINKERKRNLKIINFKRNEIKYAIYKKDGGIINDNTGLKGDTLNWSKKNMENQNNNNNDKEEKLIIEQIDISKNEKEIYEKKLKECTHLIYAIGYESNNYPKIYIDNNDNEIKQNELNFNQETTEFWLNEQKVKGLFGLGIAHPEKTKDPSGQIENAVGLAKFFAFSDKNKDRWVKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HU38</accession>
    <name>A0A1B9HU38_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Ubiquitin-conjugating enzyme E2 2</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">I206_07171</name>
        <name evidence="22" type="ORF">I206_106368</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="22" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="EMBL" id="KI894015">
        <property type="protein sequence ID" value="OCF46784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008003.1">
        <property type="nucleotide sequence ID" value="XM_019158865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HU38"/>
    <dbReference type="STRING" id="1296096.A0A1B9HU38"/>
    <dbReference type="GeneID" id="30175540"/>
    <dbReference type="KEGG" id="kpin:30175540"/>
    <dbReference type="OrthoDB" id="9984419at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0749">Sporulation</keyword>
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    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 19" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="20">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
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    <feature type="active site" description="Glycyl thioester intermediate" evidence="18">
        <location>
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        </location>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
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    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OCF46784.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="WWC72406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="171" mass="19173" checksum="FA8A52EEBA699D56" modified="2016-11-02" version="1">MSTAAKRRLIRDFKRLASDPPIGISGSPNPDNIMIWNAVIFGPPDTPFEDGSFRLTLTFSDSYPNKPPTVRFVSKMFHPNIYANGELCLDILQNRWSPTYDVAAILTSVQSLLNDPNPASPANVDAAQLFKENLKEYERRVKQTVEQSWLDNPDEIEIEHSTNVPVQAVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HU53</accession>
    <name>A0A1B9HU53_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TPR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_07177</name>
        <name evidence="2" type="ORF">I206_106374</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894015">
        <property type="protein sequence ID" value="OCF46790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019158871.1"/>
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    <dbReference type="GeneID" id="30175546"/>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
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    </dbReference>
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        <property type="entry name" value="TPR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45588:SF1">
        <property type="entry name" value="WW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="OCF46790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC72412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="561" mass="64466" checksum="877A9C85BB05DC1A" modified="2016-11-02" version="1">MNDLPEPIPASNPYYNLGTLTRRITTSSSDTQEWFDRGLKWAYGFNHAAAAYCFEQAIAHDQQCQAAYWGLAYSLGPNYNKPWEVFDEEDIKRTVEKCHSVIEEGLKLHNGTDVERAMLESISTRFPIERTSRTHKEWDVNYANTMVNLHRQFPDDIDIAALTADALMNLTPWALWDITTGTPAKNSRTLEVKEILETAINTVEGYEHIGILHLFIHYIEMSPTPELGLIPGDRLRKLSPEGGHLTHMPSHIDILVGDYRRAISSNWDAVIADEKYRKESGDLGLYTFYRVHDYHTIIYSAMFNGQYNQAMKAVNGMEDSLSYDILKVKSPPMADWLEYFLTVRPHILVRFGKWQEILSFKFPEDKEIYCNLIATLHYARGIAFAATGRITEAEEEQELYQEAIKKVPESRMIYPNSCKSVLSVGEPMLEGEIQYRKGNFDLAFRDLREAVKRYDNLIYAEPWGWMQPVRHALAALLLEQERTEEAAEVYEEDLGISGTLPRACQHPNNVWSLYGYYQCLIKLERKREAKIWEKQLDIALAVAEVPIKSSCYCAKDEVSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HU76</accession>
    <name>A0A1B9HU76_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS transporter, SIT family, siderophore-iron:H+ symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_07208</name>
        <name evidence="12" type="ORF">I206_106404</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI894015">
        <property type="protein sequence ID" value="OCF46821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008040.1">
        <property type="nucleotide sequence ID" value="XM_019158902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HU76"/>
    <dbReference type="GeneID" id="30175577"/>
    <dbReference type="KEGG" id="kpin:30175577"/>
    <dbReference type="OrthoDB" id="2241241at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000197">
        <property type="entry name" value="Siderophore iron transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000412">
        <property type="entry name" value="SIT1p Ferrioxamine B transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF92">
        <property type="entry name" value="GLUTATHIONE EXCHANGER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="380"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="550"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="56"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="578"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="594"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="633"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCF46821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC72442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="647" mass="70746" checksum="E68890AE6C01F9AD" modified="2016-11-02" version="1">MNKNHGRGDPLYPDYIISKEIEKQGDDNTAFGDKSPGVRRIEAIATCFTTWHKWVLFLSVFLVAYSYGLDGTVRYTYQATALSDLKTSSQLSTVTVVRSVVAAAAQPGFAKISDYFGRVSILFISVIFYAIGTVVQATAKGLGAFAGGAVIYQFGYTGIMLLVEVLIADVTSLRSRLFFSYIPAMPFIINAWVSGNIASAVLGATTWGWGIGMWAIIFPVMTIPLFGSLLEAEWRANRRGLLKDIPSPIKTLLQPSLWVEIFWQIDLIGLILLAAVFGLILVPFTLAGGVSNTWKAAHIIAPLVIGFVVALPAFIIWETKIARHPAVPFRLFKDTRMVLAPICIAMLLNTAWYTQGDYLYYTLTLAFDRDITSATRVQNIYSFCSVVIGVALGLVIRRVRRMKWFIVAGTLLFVLAFGLLIRFRGGFSAHDFAGLVGAEVVLGIAGGLFPYPTQVMIQSAVQHERTATVTSLYLASYSIGSALGNTIAAAIWNNSLPKHLLTSFTRYGVSDPATMAASTFLDPLTLVATYPPGTPEREAASEAYREVQRYLTITGICISTLLVIASLCLRNPRLGDQQSLPDAEGFNVPVLPSTEKETRHGNEHSPTRTAVDDEQDQYHPAPLTEGYDPGSMEANNSKSNKIMANRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HU86</accession>
    <name>A0A1B9HU86_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_07218</name>
        <name evidence="4" type="ORF">I206_106414</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894015">
        <property type="protein sequence ID" value="OCF46831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008050.1">
        <property type="nucleotide sequence ID" value="XM_019158912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HU86"/>
    <dbReference type="STRING" id="1296096.A0A1B9HU86"/>
    <dbReference type="GeneID" id="30175587"/>
    <dbReference type="KEGG" id="kpin:30175587"/>
    <dbReference type="OrthoDB" id="2592022at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="214"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="595"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="630"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="972"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="52"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="134"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="254"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="638"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF46831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC72452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="998" mass="112894" checksum="2999654DBDA75929" modified="2016-11-02" version="1">MSFSLPSSPKIKSKFKSSSSSFTSNSSNEKQFQLSSTPIIPLPNSHPLIAELTSLRQQLSQYQKAAHQASIQLQGVRLELTLSQEKEIRWERERDSLKKEVEILRTNPEPPIPLPTSNALTELSLAHRRLSTKLDLTESELNSTKLDLAKANSEIERLTKEREGDRSTINELRRIEDDREEELEWEKGERRKLEEQKKLCDLALAEYSTLVHSLDPTAVPPSNPTKSTSSIFNTPSSQRSSLDGDSSIHSELDTPPLTSTSTAITSPSPSAGEVISNLLIGQKGVQQLFTDFTSFLTSKDKRIHELETKVEELEHSTQTLTEQLRVAIEIRVEAENIKDRVLRDDESASKVIERYMIFTQKTHQTIHLHLNNLRARSTATTNSLRNELADYKKDLIIEREKNSTLLNSYNDLLENYLNESTGRRREISLRLKMISNQEKRGKSIENWLNKVKILRESIEGPVLEPDVLENLLDEGIEVISNDYSIVSNRRQDEGQNDKFKSWRKMGNLIKSNKSQKVDDGDNQINSNYEEESLARILLAEELVNTLVNDLQIETEKRMELERQRVEWLAKDAVDGVRVASNKDGIAEDGHVMFDIDDHDPDPIRGTLTPNGSSTKEPILIDTAHVHNAAPSSGANALEENDQNEEGESVPAQAQKDSDDTIPAPRSSTDESSPLVDQLSELFEPINTRYEPLQKTLHDLSHSLTNLKNDLPILESSNPSTPSTSKPNKKSHFLIISKLPSSSFKPSHDPTLLAILDELHEVIEDARVDVEIALADHERVYRGFEALLNVGKKKQSKKEEIMNEIKEYVKSKKESLSWEKLKIRIENIEFDLMLIKRSIHEIDGMEINILKELSNEKQLESNSNSNLNQRRKNVWENLNLKTISTTNIPNNNQIKTFFVGGISPTPISSSPLNSPFIDEYGFSITSNNNINNFQNDSIKKPSNVFSTVGNVSRSFSNSIIGTPRRVSDLATGLYRPNNRKSEEENSLINDKVNEEDDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HUB5</accession>
    <name>A0A1B9HUB5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH:ubiquinone oxidoreductase intermediate-associated protein 30 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_07248</name>
        <name evidence="4" type="ORF">I206_106444</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
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                <person name="Saif S."/>
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            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
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                <person name="Imamovic A."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Dewar J."/>
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                <person name="Griggs A."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="9">CBS 10737</strain>
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    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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            <strain evidence="10">CBS 10737</strain>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC68265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="690" mass="77260" checksum="92F3F2002B0C421B" modified="2016-11-02" version="1">MQRHYSDTAYLPQRSSRLNPNPNTVVCRPSRGVPVGIIQQRGTMSMPTSPTMSKMLFQTTGVDATSQDTLHTPQTAQPSSSLQAQQESTSQHGHSISNGPSLQQQYQQGPISHISPMDMFSPPSLGYSETPIYQSQPQASSSSIQHISPHPVTFPNITGQGSFNASLSRLEPPVFNTDNADFQINNNGISHIDQMRNFRNQQNCDGFHQIHQEHSDWEMDTDINFGPGGRKKRNQVRIACTHCQKACKKCSNKRPCERCVKYGLSDCVDSARKPRRTGMKRGPYKRRSSKYSESEYHLPSTLKSHVNASAPSNSNLDVKCPESAVVNFTTGNRNHQAHSQLSMTKNVAYFSPGRSYLLQNPTQTNSDKLTSEPPQNMISQNTDQVPKASEAVDKFTNNNDDPGHTNKVYPPFPKGNNQHNLVLALSNALSNPQSQQWINGKRLPLNSNSNSNNSNSITNENENGNGKKGKTSPLYPKTPIGPFPFSLKTKGKDDPFSRSVSPIKQFNSEFGFGIGFEFQQNSNFNNNNNNQEKRNELLNDVREESEISDESFSSEISNNQFIKQFNDDQNNQLQNKFQYQLPNKIHKPSLKTLISTTTSKVPTPSPITFTTTNTNTKIDIQMQSPTLFQGGMLDENDVNLANWKEWENNHIQKNDTIQTNMRDDCQEDKDKNKGSEHIDGVSFEGLMGLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HV07</accession>
    <name>A0A1B9HV07_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="13">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I206_06877</name>
        <name evidence="17" type="ORF">I206_102031</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPP phosphatase family. PP-2B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="13"/>
    <dbReference type="EMBL" id="KV700117">
        <property type="protein sequence ID" value="OCF47101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC68110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008320.1">
        <property type="nucleotide sequence ID" value="XM_019158574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HV07"/>
    <dbReference type="STRING" id="1296096.A0A1B9HV07"/>
    <dbReference type="GeneID" id="30175246"/>
    <dbReference type="KEGG" id="kpin:30175246"/>
    <dbReference type="OrthoDB" id="5593063at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033192">
        <property type="term" value="F:calmodulin-dependent protein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097720">
        <property type="term" value="P:calcineurin-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07416">
        <property type="entry name" value="MPP_PP2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041751">
        <property type="entry name" value="MPP_PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043360">
        <property type="entry name" value="PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45673">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="15">
        <location>
            <begin position="177"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="496"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="496"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="547"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="582"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="606"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCF47101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="WWC68110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="638" mass="71423" checksum="8A996E6222E711BE" modified="2016-11-02" version="1">MTSPATQTANAIAAITNRSNIVIPEIDFTQHQLENGDVVSTTERVVKDVQAPAMYLPTEEQFFSKTDKSKPDIAFLKNHFYREGRLTEEQALYILEKGGEILRNEPNLLEIDAPITVCGDIHGQYYDLMKLFEVGGNPAETRYLFLGDYVDRGYFSIECVLYLWSLKMWYPDTLFLLRGNHECRHLTDYFTFKLECKHKYSETVYNACMESFCNLPLAAVMNKQFLCIHGGLSPELHTLDDLRAINRFREPPTSGLMCDILWADPLEDFGSEKTNDTFIHNHVRGCSYFFTYNAACQFLERNNLLSIIRAHEAQDAGYRMYRKTKTTGFPSVMTIFSAPNYLDVYSNKAAVLKYESNVMNIRQFNCTPHPYWLPNFMDVFTWSLPFVGEKITDMLIAILNCCTKEELEEEEEETPMAITPETPAEADVTAERRQIIKNKILAVGRMSRVFALLREESERVSELKSISGSNTLPAGMLASGAEGIKEAIQGFEDARKSDIENERLPPDIIDPDEENPASPSGTTPHTPDESASPKLESPLAQFGSAIGSTPSPMSPQSPSTPGTPSSPGGGGGGMTWRRGHSRQTSLGTTKTSPSNRRRSLENTMHLIRDVVDGKDANGDGQLERLAEVISSPTSKGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HVM8</accession>
    <name>A0A1B9HVM8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_07090</name>
        <name evidence="3" type="ORF">I206_101820</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="kpin:30175459"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
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    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF47311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC67902.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="532" mass="61404" checksum="8D4D7852EC28ADDE" modified="2016-11-02" version="1">MGQKQNHDQEIQKENNHKSSTSSFHLNKVNDSLLKDIKEVQDISDQSNYKMGKSKSFSNLAEVFGFNYNYSRSSSRNNEILSRPKSIVNLERTSSHTKRHVIPEHLPTQIIIRILTYCCNDTLYNCLTVSRLLFNLSGRILYNHIIFDSPKDMFEKLKDSTILYENITGKITVGRKKFKDRLLKHTEEVTLHSHGDDNCNEEEEEEKNEKLSLFLENKNHQRSSSSSCSNSFNYKSKSRTNTLIEIPINCPNVSLNEIMPRLKILRIILADEFDYHLLFCPKFNSPCPLLKNLKIEKLIIIGARSPLVVLPNSFPSTITFTTPNSPPIQLNSNKKIKSTGGLPIGLKELTIILPTGRSYDLKDYEGFENIFNNNNNHSLNSIKKISIIFLTNNKRNLWQIAFYNSRDIKYLNSFSSLIEDLIKIIISLPLNSSNLNLNLNIIGIENFDGELFNMGIGIMKKGKENLKNFIIEKIKNQLYIKLVKKNKQNQINEIFNKINFINLDDWLENDGNKELGDNGFKELAKEGWREFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HVS3</accession>
    <name>A0A1B9HVS3_9TREE</name>
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    </protein>
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        <name evidence="10" type="ORF">I206_101758</name>
    </gene>
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        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
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        <property type="protein sequence ID" value="OCF47375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC67841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019157981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HVS3"/>
    <dbReference type="STRING" id="1296096.A0A1B9HVS3"/>
    <dbReference type="GeneID" id="30174640"/>
    <dbReference type="KEGG" id="kpin:30174640"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11476">
        <property type="entry name" value="SLC5sbd_DUR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1730.10:FF:000006">
        <property type="entry name" value="Urea active transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031155">
        <property type="entry name" value="DUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154:SF2">
        <property type="entry name" value="SOLUTE SYMPORTER FAMILY TRANSPORTER (AFU_ORTHOLOGUE AFUA_6G03200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="361"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="394"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="425"/>
            <end position="447"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="493"/>
            <end position="514"/>
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    </feature>
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            <begin position="594"/>
            <end position="614"/>
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        <location>
            <begin position="626"/>
            <end position="647"/>
        </location>
    </feature>
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        <source>
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        </source>
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        <source>
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        </source>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC67841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="672" mass="72176" checksum="D3CAC849ED80B284" modified="2016-11-02" version="1">MSASTILPQGAGYGVVIGMGLFFSLLMIGITWMQTRYTSHKTSSAEEFNSASRSVPPGLIAAGIVSAWTWAATLLQSSATAYKFGISGPWWYASGAAIQILLFAMIASKLKQNAPYCHTYLEIIRARWGKVAHLTFLFFGFATNIIVSTMLILGGSATVSSLTGMNTVAACFLIPIGVSIYVLTGGMRATLIADYSHTLVLYCILIAFALTAYGTSNIIGSPSKMWDLLAQAAEEKPIAGNAHGSYLTMRSKSGLIFGVLNIVGNFGTVFNDQAYWQRAIASNPRTSVKAFLWGGIAWFGVPLGIATSLGLSAVALAHGENPLITLTSEEVSAGLPAVKAAGALMGQSGATAMLILLFLAVTSACSAEQIAVSSLLTYDVYGSYINPNPSEKQILWVSHLCIFGYALFMGAIATAFNYIGISMGYLYELMGTIIGCAVVPIALCVTWKKCNAKAAISGAILGFLAGVAGWLGITSKLNDGVINVETTFGDYEMLTGNLLSIGVGGIITVVWSLLQPDNFDWDITRNINVQTETNITEHSQPQSPITDQRIIEKEKEINGTEEASPEYAQTERVVEEQPSDLVEEREGLKKAFRFAAWSALTLVILLIFVIPLPLFFSSHVYPKSGFTVWVCVSLIWLFVGLAMVGIYPMWEARKGLMQVARGIAADLRGKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HVZ9</accession>
    <name>A0A1B9HVZ9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glutathione synthetase</fullName>
            <shortName evidence="10">GSH-S</shortName>
            <ecNumber evidence="10">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I206_06344</name>
        <name evidence="16" type="ORF">I206_101688</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
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        <reaction evidence="10">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
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        </reaction>
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    <comment type="cofactor">
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            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10 12">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
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    </comment>
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    <keyword evidence="5 10" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="9 10 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathione synthase substrate-binding" evidence="14">
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            <begin position="216"/>
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        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <feature type="binding site" evidence="12">
        <location>
            <position position="149"/>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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        <location>
            <position position="151"/>
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        <ligand>
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        <ligand>
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        <ligand>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
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    </evidence>
    <sequence length="523" mass="57937" checksum="874C8A5BF9D2A624" modified="2016-11-02" version="1">MSVSTTLPAWPPALSPEQHQQLILLSSTYALSHGFTLLPPQSDNPPKSAISAPLTLLPTPFPRKLYELAISLQPLYNALYARITLDWEFLDRVMGGSVSKVDSFQGELWRGWKSIRNDLIQQLQLGLFRSDYLLHESAKEEELSIKQVEFNTIAASFGALSQRSTEMHKYLQKATDGFYSISPHLANSANFPQNEPLKNLAAGLAQGWKAYDEKDAIIMFVVQEGERNVFDQRWLEYELLESHGIQVIRHTFSELSSLATIEPTTKKLLLPSPLLPSSASKEVAVIYYRAAYTPTDYPTSSEWSTRILLEKSKAIKCPSMALQLSGAKKIQQVLSEPGVLEDFLLGKDRPDVGFGIGAGKLTQIDVDNLRSSWIGLYPMDDSKFGKEAYELAIKHSERFVLKPQREGGGNNIYRENVPIILKGLEAETEEEGEPSKKEGYILMELIEPPKGLRNHLVKGGDNHSRNSDIVSELGVYGVSLFGGDISQNITSTAGTLLRTKGRESDEGGVAIGISSIDSPLLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HWK0</accession>
    <name>A0A1B9HWK0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_06533</name>
        <name evidence="3" type="ORF">I206_101494</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="OCF47630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HWK0"/>
    <dbReference type="GeneID" id="30174902"/>
    <dbReference type="KEGG" id="kpin:30174902"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="42"/>
            <end position="62"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="71"/>
            <end position="81"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="122"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="141"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF47630.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC67584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="141" mass="15031" checksum="E1DDD368F7910145" modified="2016-11-02" version="1">MSDRRIFRGIVASADERQHNGRNYTRDPPTPPDSGISRESSDTFSVKDTGTEATAGSDNGSDATAGFVNGSYKSSETSPVVQNEVKAMAESNNSSDKLSQSFSVVSTVGERVEADGDVSPKEDSEDDPDRVKVNHSRQGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HWW1</accession>
    <name>A0A1B9HWW1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="3" type="ORF">I206_101376</name>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="OCF47748.1"/>
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    </dbReference>
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        <property type="protein sequence ID" value="WWC67468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF47748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC67468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="133" mass="15035" checksum="4073EDB137363AA3" modified="2016-11-02" version="1">MTRAKSTNNENISRKKRSKNKKDNEIRINSKQLLEKSDNEFQKKNKVSDEKTIPTSSEFIKDESKISIPVKIGEDIKFEVHKKLMSTGSFGWSGNRNSKITLGDGKNVNVSISVNIVVQNSSSQKKDSLAKEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HX69</accession>
    <name>A0A1B9HX69_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="6">PPIase</shortName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_05720</name>
        <name evidence="9" type="ORF">I206_107394</name>
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    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
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        <text evidence="2 6">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
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        <text evidence="5">Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily.</text>
    </comment>
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    <dbReference type="EMBL" id="KI894014">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="WWC73427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019157439.1"/>
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    <dbReference type="STRING" id="1296096.A0A1B9HX69"/>
    <dbReference type="GeneID" id="30174089"/>
    <dbReference type="KEGG" id="kpin:30174089"/>
    <dbReference type="OrthoDB" id="271386at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01928">
        <property type="entry name" value="Cyclophilin_PPIL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000012">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
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</entry>
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    <accession>A0A1B9HXD5</accession>
    <name>A0A1B9HXD5_9TREE</name>
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        <submittedName>
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        <name evidence="3" type="ORF">I206_05810</name>
        <name evidence="4" type="ORF">I206_107481</name>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
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    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="OCF47945.1"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="LEBERCILIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        </location>
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        </source>
    </evidence>
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</entry>
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    <name>A0A1B9HXQ3_9TREE</name>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
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    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I 23 kDa subunit family.</text>
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        <property type="protein sequence ID" value="OCF48044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
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                <person name="Chapman S.B."/>
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                <person name="Goldberg J."/>
                <person name="Griggs A."/>
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                <person name="Imamovic A."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
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                <person name="Dromer F."/>
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                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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                <person name="Hansen M."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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            <strain evidence="2">CBS 10737</strain>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
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                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Berlin A.M."/>
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                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="McCowan C."/>
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                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
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                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 10737</strain>
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    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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                <person name="Litvintseva A."/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC73313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="926" mass="104316" checksum="7BAFD3CE231ECF2F" modified="2016-11-02" version="1">MASSSIPILSGPQTPITSPRERSDTILTTSSSDSYPLLQTPPSASILGVLNNDPYKPLISSPSILTRNRQNSYGFGGILASSPETNQRLSASPQIYPSHSDIGSSDHTEPNDIARNGHDELENNGQSSLSTAEIDDTENFHNGTRRSKFKAAVRQRLERSRSSLRNLRGSKNEETENNSGLSNPPSLISIDSLMPPSSINSSRPKKSRLKSLLTISRNPSLASIKSTKSVNAEPVTTHLPLLHVHSTHRLANLNEAATRILQTGHHEITVRDFAHNPNHLIPAAARARHLSDDATTQLDEGILFTKDRFMGTVSPVSDISRNHVTNSRNTARPKRITRPRATSMPLLDTSAALLSEEPEEIAEDEQNLFDTVLPREIKVQILKTLLDMHKSDVGNTRWSGEVGGKRELIKLSRVSKSWQHLCLDGQLWSDLNFTPFAHVLHPNTLKRIVESSLPFITTLSLQGLNTLRGSILIPCLSPFDKSASFIDRTEGVRVWMPNLRSIDLRGANRLTTTELCDILSGSPGLKIINLKGVQACNSEVIRTIARSLRNMESLDVTRCKDLTLGDIIFLIRAMDEHQSLKMKCLRIGGMKSYGRHASEFLPLLAKKLINLEIFDVQECTHIFDEDFEKFSEILQESKYKSRLNHLNLSGCKGLKGRFLYHLIGVLPNLRILELAELNEMFKGLSKNEKDKLEIDLIEFIKTIPIIERIDLDFTGLNGGISDKFLNNLLSNSNRDDNIPIGKNLKELRIGHSIDITSEGLIKLIKGLKNLEILEIDNTSADDKVLKTFIKFKSKGTISIIDCRSIRTSELDKIINLTKCRNPNTSSQFKKNKWEFKPFEYDEKEFEILCTVKSFQSWRNTKIPINWRILRQDQNHKIENDEILQNKFLRKEKQGKSWWSTGNSTLEDWNDFEEEEEVEGVRGCIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HZ16</accession>
    <name>A0A1B9HZ16_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rhomboid-type serine protease</fullName>
            <ecNumber evidence="10">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I206_05306</name>
        <name evidence="14" type="ORF">I206_107150</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Serine protease involved in intramembrane proteolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="10"/>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC73184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009746.1">
        <property type="nucleotide sequence ID" value="XM_019157028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HZ16"/>
    <dbReference type="STRING" id="1296096.A0A1B9HZ16"/>
    <dbReference type="GeneID" id="30173675"/>
    <dbReference type="KEGG" id="kpin:30173675"/>
    <dbReference type="OrthoDB" id="2146116at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002610">
        <property type="entry name" value="Peptidase_S54_rhomboid-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936:SF69">
        <property type="entry name" value="RHOMBOID-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936">
        <property type="entry name" value="RHOMBOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="509"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="531"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="561"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="12">
        <location>
            <begin position="411"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="28"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="107"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCF48527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WWC73184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="593" mass="65502" checksum="00E71BFACEDB7902" modified="2016-11-02" version="1">MPLTGPRPNPASAKNAINFPDYHEEGIPAYSSAEYTPPFQERGHHSTSTPSYPHQSSPESGTARLEPVDNRYQSGQSEAQEIMRDYRNSKLDDEGDVGLLSSTRPGEYSKEYENPYEDKDIQQQPRSISPSLGPWDSASQRSLPFHSNQSNPYPNLYQPSHIPLSQNSSSIINNTKHNPKAASYGGLSYIDENGEYFQTKYSRPASTTLQLENNQNDNVEMGLIGNLDRSNGNIENPYYSSSTSKYEESPYPYPTKNAGLTLRGPNALYDFLLFPTGLDRLLALFGVKNGQYPIEQAIERKRRGIGGQRWPIAAWGLAIVMTALMVYEMVANYQAMGSPIATKPTFNPMIGPSSEVLINIGARFPPCMKLVEDLPPSFQLACLNDTSSTPTSSCSIEEICGHGGFNGENPDQSWRFVYPIFLHVGIVHLLLNMIAQITAAAQVEREMGTIPFLIVYMAGGIYGFVLGGNFSRTGIPSVGASGALFATNACVLVDLILHWKYEERPKLKAFLLAAEFLIGFGIGYIPNAVDGLAHLGGWAVGILLGIILYPSISETKRHKYILWVSRVIALILTILAFVLTIKNFCEFYPNRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HZ25</accession>
    <name>A0A1B9HZ25_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_05267</name>
        <name evidence="4" type="ORF">I206_107187</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="Heitman J."/>
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                <person name="David-Palma M."/>
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                <person name="Mohammad A.W."/>
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                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC72843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010083.1">
        <property type="nucleotide sequence ID" value="XM_019157365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I024"/>
    <dbReference type="STRING" id="1296096.A0A1B9I024"/>
    <dbReference type="GeneID" id="30174014"/>
    <dbReference type="KEGG" id="kpin:30174014"/>
    <dbReference type="OrthoDB" id="9997102at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF25">
        <property type="entry name" value="NMRA FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="2"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF48864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC72843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="312" mass="34529" checksum="58D755EC0F50D5E8" modified="2016-11-02" version="1">MSRSILVTGATGKQGGALIQSLISTPANNFTILAVTRNANSSGAQRLQSKSKAIRLVQGDLDKASELFVNAKKASPDGKIWGVFSVQGVAMKSHDDIINAPEVKQGIAIIDESIKANVETFVYSSVERGGPEKSWNDPTVVPHFQTKHMIEQHLVDSTKGNPMKWSILRPGIFMENLEPNFGTRVFMTALKDTLEGKKIGWISTYDIGIFAAAMFRDPVKYDKKAFSLIGEPIDFNEISTIFKRVTGKPFTPTFSFLGSLLKSATKELGIMINWFGTDGFKGTDIKVLKEIHPEMMDFETWLKTKSNFVKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I072</accession>
    <name>A0A1B9I072_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L-serine ammonia-lyase</fullName>
            <ecNumber evidence="5">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_04624</name>
        <name evidence="13" type="ORF">I206_105804</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="5"/>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF48937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC71845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010156.1">
        <property type="nucleotide sequence ID" value="XM_019156354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I072"/>
    <dbReference type="STRING" id="1296096.A0A1B9I072"/>
    <dbReference type="GeneID" id="30172993"/>
    <dbReference type="KEGG" id="kpin:30172993"/>
    <dbReference type="OrthoDB" id="7773036at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06448">
        <property type="entry name" value="L-Ser-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000040">
        <property type="entry name" value="L-serine dehydratase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF2">
        <property type="entry name" value="CATABOLIC L-SERINE_THREONINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="11">
        <location>
            <begin position="11"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCF48937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC71845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="335" mass="36482" checksum="B80E28F136A71D30" modified="2016-11-02" version="1">MPETSPSRPWIETPLLESRALSKLNGCRVFLKLENLQPSKSFKSRGIGNFIVESIKSDPSRTPHFYISSGGNAGLACVTAASTLGYKATVVVPLSTKPMMIEKLKIAGADVIQNGATWFHADTYLREELLDKDSNGVYVPPFDHHHVWEGASTMTEEWEKQLSIIDGNKNERTNADLVVCSVGGGGLFCGIMKGIFSNERKTKVLTVETIGAESLYKSIEKGELITLPGITSIATSLGAVTVAPKAFEYANENKDLVKSIVVKDEQAVKALLKFASEENLIVEPACGATLAPAYEGRLKELFPDLKEDSKVVLVVCGGSAVNLELLDEWQRKYIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I0P0</accession>
    <name>A0A1B9I0P0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fe-S protein assembly co-chaperone HscB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_04799</name>
        <name evidence="5" type="ORF">I206_105976</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HscB family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010331.1">
        <property type="nucleotide sequence ID" value="XM_019156529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I0P0"/>
    <dbReference type="STRING" id="1296096.A0A1B9I0P0"/>
    <dbReference type="GeneID" id="30173168"/>
    <dbReference type="KEGG" id="kpin:30173168"/>
    <dbReference type="OrthoDB" id="448954at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.20">
        <property type="entry name" value="HscB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004640">
        <property type="entry name" value="HscB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036386">
        <property type="entry name" value="HscB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009073">
        <property type="entry name" value="HscB_oligo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00714">
        <property type="entry name" value="hscB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021:SF15">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07743">
        <property type="entry name" value="HSCB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47144">
        <property type="entry name" value="HSC20 (HSCB), C-terminal oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="94"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF49112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC72017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="264" mass="30162" checksum="92B0E04512A8FE15" modified="2016-11-02" version="1">MMNKISLPSSSIRRLPLSPLRILSIDKSQHIRKYHSTSPPAPPNQLCSSCSKSIPLPLTPCPECSNLLPLPTNLSYHSLLYLSSPIINSESNENPKKIFDIPKELSHLPSNGFGLDKIDLRSKWLRRQRELHPDKFISKGEKIINLARDLSGRVNEAYNVLGDELKRTEYLLSINEKSTEETDKLDDPMILAEILEAREELEEANTFEEIERIRTVNHEKVEYMIKQLHSAFSETPPNLDLAKELAVQLRYWRGLENAAKEKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I1G1</accession>
    <name>A0A1B9I1G1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cullin family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_05066</name>
        <name evidence="8" type="ORF">I206_106240</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010592.1">
        <property type="nucleotide sequence ID" value="XM_019156790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I1G1"/>
    <dbReference type="STRING" id="1296096.A0A1B9I1G1"/>
    <dbReference type="GeneID" id="30173435"/>
    <dbReference type="KEGG" id="kpin:30173435"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cullin family profile" evidence="6">
        <location>
            <begin position="445"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCF49373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC72278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="808" mass="92245" checksum="44014EA9DFDA5D6D" modified="2016-11-02" version="1">MSSLIVLPSRTNAFSAYQPSKNAHTDFISAVDLGRGGSSKEGVNTIQINVPVRTNQTPTNELLQSLLQAIPNLLSGKPTIQSFHTLSHTCHQLVLQPHTLGPTIYGRIKEELEKSANGLVREWRGSIMSRQEGWLIRFVEGWKLWEKRINLLSAIFVYLDRVYSNSLNGIASIKELSITIFRNSIWNNEIIAEKTRSEFLAWSKNERELERVLDDQRPTIVEITNLSKLLDTFNESIVKPYIELTAEHYSSNAEVHMEEVENNIMKPCKYVEWVLSKVIEEKERAEINLRKDVAEQVVRAVRKSAGEDVAKRVIRRAVDECMDSQNVESLSRLCTFSIDVNSFGVLVQAVEDHLEDRLKTLISDHANDSKMIDATLKIKRFTDKAISSLFSSSEDLSLDKSEDVEDKVFAKDISEQKRLRRNRQFELEEASRVGFKKGLGSRQNAPAEWIAKHLDLAMRRGPSLSDSEFNAHLDEIIALIGFTKDKDVFKAFYSSQLAKRLLLGRSASDDMERNMIAKLQKEMGEEFTSGDIMMKDLTLSETLVRSYQITQSKEPETYKDAGNFTANVLTESAWPAYPLLKDGWNFTLPPNLQSSVDLFTSWYTTQHKNRQLSWRFQLSTVTLSSRVGKDKYEIGVSLFQAVVLLLFNEEDTLDFKSIQSRTGIETQELVRTLQSLALGRKGTRVLLKKPPGKEVNPTDVFAWNKGFTSERIKFKINGIQQDMSAEESRKTNEQVHIDRVSVLEATIVRIMKGKKKLSLQLLIDNVVSDVVKRFPPDVKEIKKRVESLIEREFLMRDEEERGVLHYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I1G4</accession>
    <name>A0A1B9I1G4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_05037</name>
        <name evidence="7" type="ORF">I206_106212</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with ODC and thereby sterically blocks ODC homodimerization.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ODC antizyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010564.1">
        <property type="nucleotide sequence ID" value="XM_019156762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I1G4"/>
    <dbReference type="STRING" id="1296096.A0A1B9I1G4"/>
    <dbReference type="GeneID" id="30173406"/>
    <dbReference type="KEGG" id="kpin:30173406"/>
    <dbReference type="OrthoDB" id="5959761at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008073">
        <property type="term" value="F:ornithine decarboxylase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075523">
        <property type="term" value="P:viral translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002993">
        <property type="entry name" value="ODC_AZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038581">
        <property type="entry name" value="ODC_AZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02100">
        <property type="entry name" value="ODC_AZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0688">Ribosomal frameshifting</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="84"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="168"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCF49345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC72250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="376" mass="40756" checksum="13F7EA489E0B0F16" modified="2016-11-02" version="1">MNHQSKNININRNLCPAGELGNAGAGATNSTPLLFSSHHHHDIDNAYNPPLAIARAGGKGGQVYVYSDDVGCGDQSSYASFAGGGRQWGDDFDNASESSETTRDSLMSYLHEPLSQISPFNSPTHSRRPANMAGPLTPPSSFTQSVDIPQQATNQTHSSFSLPLTPISCSSMSENSSPPKSQISPKHKTVLPNKQEREVIHLISSIFPNHFRDISSLSSTLEIVTPPSNLLKGFIVDHKVRTVFIHLPPLSISSNTHQRPEALSPNFSQVLRPHDPLLSISPPLSSGLAMSNASGMTNFGLDIKEYLTASLDLSADALEASNMVLLLDRDENDQESLGELLHSLMYVGGQVLKSPAKSLNGWEWDIRKWVLVGMDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I203</accession>
    <name>A0A1B9I203_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_04102</name>
        <name evidence="3" type="ORF">I206_104320</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010799.1">
        <property type="nucleotide sequence ID" value="XM_019155841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I203"/>
    <dbReference type="STRING" id="1296096.A0A1B9I203"/>
    <dbReference type="GeneID" id="30172471"/>
    <dbReference type="KEGG" id="kpin:30172471"/>
    <dbReference type="OrthoDB" id="2310204at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
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                <person name="David-Palma M."/>
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                <person name="Mohammad A.W."/>
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                <person name="Yurkov A.M."/>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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                <person name="Heitman J."/>
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                <person name="Dewar J."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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                <person name="David-Palma M."/>
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                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
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                <person name="Heitman J."/>
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                <person name="Imamovic A."/>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
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                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF50161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC71662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="354" mass="40725" checksum="B126F8F6ABDF75A3" modified="2016-11-02" version="1">MAPLAETAQVSYTNAVPEILLIIRTTFQNVDQTSDRPIESQLISQASIAFQQECFFNSEFVRIHKSIVEAEHVRREYVLKQREYATLSAALYNLQFASEQADILGAPLPQVLQDHIKEAKEKLKLLEESTRQLGLKLPDIDKLETQKVGCLISRQLFQISLKLIFPKPTKVEIENQQAEIKAISKELEMVRKKQTELEKKLKLKEKQLSKLQKVEAEFKNTNADLSAAKIVMSQDQDDLVNKNTEINKLERKILDIEKENTGMKQLIADVNDLLEKKNQPLPTATQVLEDIPHESKVESQRLTGADQRVKPTKQDYYTLFDKHHRQTVELDQLNEILEDIKFTILKLEGEPEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I419</accession>
    <name>A0A1B9I419_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5'-3' exoribonuclease 1</fullName>
            <ecNumber evidence="5">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_03579</name>
        <name evidence="13" type="ORF">I206_105519</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the 5'-3' exonuclease family.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="5"/>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011479.1">
        <property type="nucleotide sequence ID" value="XM_019155325.1"/>
    </dbReference>
    <dbReference type="STRING" id="1296096.A0A1B9I419"/>
    <dbReference type="GeneID" id="30171948"/>
    <dbReference type="KEGG" id="kpin:30171948"/>
    <dbReference type="OrthoDB" id="372487at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000002">
        <property type="entry name" value="5'-3' exoribonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016494">
        <property type="entry name" value="5_3_exoribonuclease_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041385">
        <property type="entry name" value="SH3_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040992">
        <property type="entry name" value="XRN1_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047007">
        <property type="entry name" value="XRN1_D1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041106">
        <property type="entry name" value="XRN1_D2_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047008">
        <property type="entry name" value="XRN1_SH3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF7">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18129">
        <property type="entry name" value="SH3_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18332">
        <property type="entry name" value="XRN1_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18334">
        <property type="entry name" value="XRN1_D2_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006743">
        <property type="entry name" value="Exonuclease_Xnr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="1 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Xrn1 N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 D1" evidence="10">
        <location>
            <begin position="740"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease Xrn1 D2/D3" evidence="11">
        <location>
            <begin position="933"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 SH3-like" evidence="9">
        <location>
            <begin position="1178"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="461"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1256"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1368"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1296"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1376"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1406"/>
            <end position="1449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCF50260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC71561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1455" mass="163445" checksum="3153BEE695D0C070" modified="2016-11-02" version="1">MGIPKFFRWISERYPLTSQLITPNSIPTFDNLYLDMNGIIHNCSHPPSSENDPHFRITEEQMILAIFAYIDHLFTKIKPQKVFFMAIDGVAPRAKMNQQRSRRFRTAKDAVEKRREAEKKGEKLPEEKAFDSNCITPGTPFMARLSQHLKYYVTKRISEDAEWRNVKVILSGHDVPGEGEHKIQEFIRLTKAQPDYNPNTRHCLYGLDADLIMLGLLSHDPHFCLLREEVTFGRKSKKTTGLANTNFYLLHLSLLREYLDLEFGDLATQISFKYDLERIIDDFILMAVFVGNDFLPHLPDLHINEGALERIWGIYKEILPVAGGYLNEHGTISLPRLQMMLDKLAQFEADNFEAEYADQNWYKGKQGKEIEAMEKARKKGKMIITKDQQKILNQVKQFISNHQAKPTSADRCVLVNNFTARDQRFVQELGDDLHLVTTWDEVDDYGQNLVVMTFNLEGVSEDETSAGAGEDADGEEWESEEEDEASEGALAIQRVFAKYNKAKVVENVVEDFEEAYEEKMKENLDDWKKRYYKEKMDIDFNVPEEMHGIVYRYIEGLQWILNYYYKGVSSWGWFYNYHYSPRITDLKGIPDFKFDFDLGKPFTPFQQLMGVLPEESKEHVPSAYRDLMYEETSPIIDFYPKDFALDMNGKKQDWEAVIKIPFIDEVRLLRAMASREVRLTSEEKSRNQNYVATQFVYDGEQESSYPSSAPGYFPDLPKSQCRSSPYHLPTLGGGIELVLGLLDGVHLGAKALAGFPSLQTLPHQGTLGYHGVNVFQSDSKNQSMIITVTSKHDRPNTGEIAKGLIGQRTFHSWPYLHEGMVVAVSDDLFKYELQKMGKSAKVVSTPHNPFQAIAWKKTADHIEYHNSKRFGIITGNIDVVLHVRPLKGMKRLHTGALVKDYEAPEKEIAQAYQLAVNQVTFEDERYIEQAAPPMSQEFPDGEKVIFLGHMAYGTAAQVIGTTETSLDVSLAFFPSEKQENLNFSKLVAHRPAGVYYPSPVLSRRLGIHPLSLSRITSTLLVLLNDGSKTNIGLALKFESKGLKVLGFSRKNDRGWEYSEKTAGILREYKEAFPEPFANLDNRSGDIVTSAELCPTAENPDQVIKAMKKWLKERDLVDPDTVSLFAEQLEKESVEMIEKLANQYTSQKSHSHIKRAVMKSIPRQAVLKPSHAIYRLQGQQFAVGDRVIMVQDAAAGGVPLAMKGVVVGLGTRDIDVVWDVPFMGGETLQGRCSEYRGSTVAFTSVLNLTKPQFAIGVGGESNDNRGVGDSQPFKPQLGPRPVLQMQNYQPSAPGRRTFNNSNTHQQQPQIMKNPNRSQSGQHVNGNQSYGNATKGVKSQPQVDSTPQAGPQSHGEKLANVLGAKHYAHRPAGHAVPPQSQHRSPVQNTIPLPLPQIPVQHSQQANGHGHGQNGSSGGRGRGGFRGRGGGGGGGSQQRGRGRGGNRGGARGGAPANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I4I7</accession>
    <name>A0A1B9I4I7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Chromosome transmission fidelity protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_03750</name>
        <name evidence="5" type="ORF">I206_105340</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011647.1">
        <property type="nucleotide sequence ID" value="XM_019155493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I4I7"/>
    <dbReference type="STRING" id="1296096.A0A1B9I4I7"/>
    <dbReference type="GeneID" id="30172119"/>
    <dbReference type="KEGG" id="kpin:30172119"/>
    <dbReference type="OrthoDB" id="121932at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28605:SF1">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28605">
        <property type="entry name" value="CTF8, CHROMOSOME TRANSMISSION FIDELITY FACTOR 8 HOMOLOG (S. CEREVISIAE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="112"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="172"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="193"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="210"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="225"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF50428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC71385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="31352" checksum="85491857DC0E3DA2" modified="2016-11-02" version="1">MRIHLQLHPSQFDNPIQSSSSSSSPIIQLGGDLVLVELQGELSYEGNKSNGVVGVIGLDRPDKPTLHLGSHHLLHGKFQNLQKPYAIIRKSLNILNSNENENDIIKVESENFENSFSSSSSSSSSSSSSEEEEEDLFEKLSNTTPLKRKKIMIDSSPNSSIYNEPLTPIDYSSELDFSSPSRSIDEFNNNNNDNDEESNDEEENIEKEEEERLNKRIKIENSFKKEKKQKQKQQLRKRKQGEIERIRSYQVIGIVKKKLVFALRPEPLVAPTILPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I4J8</accession>
    <name>A0A1B9I4J8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial glycine transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Solute carrier family 25 member 38 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I206_03746</name>
        <name evidence="15" type="ORF">I206_105344</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>glycine(in) = glycine(out)</text>
            <dbReference type="Rhea" id="RHEA:70715"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011643.1">
        <property type="nucleotide sequence ID" value="XM_019155489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I4J8"/>
    <dbReference type="STRING" id="1296096.A0A1B9I4J8"/>
    <dbReference type="GeneID" id="30172115"/>
    <dbReference type="KEGG" id="kpin:30172115"/>
    <dbReference type="OrthoDB" id="1924968at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015187">
        <property type="term" value="F:glycine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904983">
        <property type="term" value="P:glycine import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03064">
        <property type="entry name" value="SLC25A38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030847">
        <property type="entry name" value="Hem25/SLC25A38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181:SF3">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="27"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="158"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="251"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCF50424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WWC71389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="351" mass="37348" checksum="1189B6DC3BAC4D3F" modified="2016-11-02" version="1">MADSATASVAAYPSSSSSSSSSSNNGLKAYHHLASGALSGLSSAIVLQPLDLLKTRLQQGGFGEEGNPTKRRRIRGVVRQVLTEDGVKGLWRGTVPTLVRNVPGVAIYFYSLSSIRHRLSSIPYFAVTVPLPNIQSPSSSSPSSPSSKSTSRSAIIKLSSGGNLMAGAIARTSVGFILSPITVIKARFESNRYANYHSIPSALVSLYRTNGIRGFFQGFTATAVRDAPYAGMYLVFYEKGKELLGRITGIPNAALHSGSGVMAAVAATLLTSPADVIKTRMQVNPAEHPSLRKAVIKVLQDRGPIGLFSGTSLRISRKAASAAIGWTVYEALLLFLRDREGNNQEQFSKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I5E4</accession>
    <name>A0A1B9I5E4_9TREE</name>
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        </submittedName>
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        <name evidence="2" type="ORF">I206_02794</name>
        <name evidence="3" type="ORF">I206_102445</name>
    </gene>
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        <name type="scientific">Kwoniella pini CBS 10737</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF50738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019154554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I5E4"/>
    <dbReference type="STRING" id="1296096.A0A1B9I5E4"/>
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    <dbReference type="KEGG" id="kpin:30171163"/>
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    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37487">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37487:SF2">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628429" evidence="1">
        <location>
            <begin position="19"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF50738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC68516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="236" mass="21927" checksum="A0D3692EECA77A88" modified="2016-11-02" version="1">MFAKNIILAAALVGQAYGLTINTPASLVQCQPASITFAEGTAPYILAVIPGGQVSAAAIETIDDNLTSSPLTWTVNLASGTSITLKLTDSTGNIAYSSPLTIQAGASNSCLNSTAATSGVSTGAVTTTVSSSGTASAVSGSNAVSTTSTSAVASSSAAASSAMSSAAASSAATSKAASVASAAGSATSAAGSAAGAATSAVASAAASAAKSGALSNKMIALPAVALALVGGLAALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I5G6</accession>
    <name>A0A1B9I5G6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_02821</name>
        <name evidence="3" type="ORF">I206_102470</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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            <taxon>Cryptococcaceae</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TTI2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF50765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="TELO2-INTERACTING PROTEIN 2"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00034736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF50765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC68541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="462" mass="53181" checksum="917D32242D016073" modified="2016-11-02" version="1">MAIVEDVTAEDEVTQVEEQSAGDLISELEKLTAQLQVPTELVPGFMAALDQNALDHYRLKALGILHDIRGKVNSPKWEEVDSEVQFKVMENVIRLNGDDPWSSVDIRSIIQDLLPKLDHSIPLLILPKLKPYFASHPSLSSNFRALSRPIGGKDSTIDLHDIQPFKDPNSWGIINLLSFSLEQLNSIEIEKNIGLILPPTLILMDDWEPLWRLKGTKILEKWINKLNKEIMKLMGIDKLLINSLIHTISLQSNPPLKGILEITIKLIQKCNENYSKEMIDFYSEIIEKGIIQGWIYAPSGLEGRSILIHINEMLLVFCDLMGTGIIRWLKNIIPNLLQPLQYPPTQVVLPHYQSNLSTLLYIMKKIRKTERVERWRGQILNILCRLWVQLKERRGILSLEEEEEEDENDKNLNEEIRSLIKSIFQELENQIPSIKQDEFNKLLQLSPNLFNDFISNNLNLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I5N1</accession>
    <name>A0A1B9I5N1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Methyltransferase small domain-containing protein</fullName>
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    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_02887</name>
        <name evidence="7" type="ORF">I206_102536</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
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                <person name="David-Palma M."/>
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                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="David-Palma M."/>
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                <person name="Mohammad A.W."/>
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                <person name="Litvintseva A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
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                <person name="Zeng Q."/>
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            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="kpin:30171685"/>
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        <location>
            <begin position="21"/>
            <end position="101"/>
        </location>
    </feature>
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        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC69028.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="218" mass="25043" checksum="E9476E0CDBAAC29F" modified="2016-11-02" version="1">MSIAFQGKPYRYNEDFAESCGDLIILTSDGQALKTDSELLKTASPVFDSMLSRLSLDHSSSAIKLYLQTIRDEAIDFTDITYETFKETLNMCLKYETKMQGLGLLGQINEGKGVIGHFGAENGFELFCLMPNFNDMLTSCRIIKDVRSRTVNNTKYGDFWNPQLWKQDTIKDVRGDWVWAYLYAHNPTKYPRGSKDYWEDVSNRFLRLLCGVYDTVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I7B2</accession>
    <name>A0A1B9I7B2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_02035</name>
        <name evidence="11" type="ORF">I206_104504</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
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        <property type="protein sequence ID" value="OCF51321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC70553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I7B2"/>
    <dbReference type="STRING" id="1296096.A0A1B9I7B2"/>
    <dbReference type="GeneID" id="30170404"/>
    <dbReference type="KEGG" id="kpin:30170404"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="377"/>
        </location>
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            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="31"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="458"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF51321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC70553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="496" mass="54801" checksum="D47FADBA25ED6694" modified="2016-11-02" version="1">MRFFSRNKNIDDNDGQKATRTALVRRLDLFLMSYVCVSYCMKYIDQQAHSNAYVSGMKEELHFKGNQYNWVGTYFSIGYTIGTIPSQFLTARFRPSVIVPMFEITWSILIMINAAAKNVNLIFGMRFLIGLFESIAYPGFVSVLASWYTPAELAKRVAFLQASSAAGSMFSGYLQAAIYKGLNGAHGLSGWRWLFIIDGIISLPIACSGFWLIPDTPKNSRAIWLKPHHLEEAEERMKEIGRAPKGKLTLAKVVAVFKEYPAWIIMLCYPPCIVAGQAISYFNLYLKSNPSGHKFSVYQVNLIPTGGQALQIVATIGSAALSDYFQARLAMIWIVAGIGMLGHILLSIWDIGFNGQFAGYMLIYCAVGAGALMLTWFSELCSADAEVRTLIIGLANGIGYAWISGFPFLMYPASQAPHYKYGYKMGAGFYAIAISGCTIIALLVRKYGLPYQNVPRSKLEGGSDSSIESGVPENEEEKVEGEAIPAVDRLSSHANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1B9I7E7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_02191</name>
        <name evidence="3" type="ORF">I206_104653</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
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            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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        </source>
    </reference>
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        <location>
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            <end position="156"/>
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    </feature>
    <evidence type="ECO:0000259" key="1">
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="265" mass="29838" checksum="788DD7E4A88E88E7" modified="2016-11-02" version="1">MLAVFLGASKGIGYFTLLNLLQTTKDWNTILLLRKPDCFDKNELIKPFIENGRIQIIKGDATNENDVENLFKIGKVDLVISTIGATPSFGITGIKIDQPDLCTKGSIALLHVLQELNYQPRVIVTSSMGIGESHKDMPLAMRLLYSWLLEKPHQDKMSLQYLFHKSSKFLPNLNSSKDKPPKSLLSQSNIESIKSNFLNEVIIIRPAFMPTEEPFDALKNPSKGYKVKEDLSCYTILRSDTGRFISEKCLPGQNEWVNKCPVIGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1B9I7T2_9TREE</name>
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    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the UreD family.</text>
    </comment>
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        <property type="protein sequence ID" value="OCF51539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF51539.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC70764.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="360" mass="40283" checksum="A59521308C1F0ABD" modified="2016-11-02" version="1">MSSHSINTRSNSSDPTTKSYFNSPKIKKLSPGSGLVHLSSSSSSSSQSSNEIKAKFSTLLSSYPLKLLTPKLLPSQPLNLGILYTLSYGGGLVSGDLISLKIEIDKGCGLVLLTQGSTKIFKKRRSKKLYNYNNTNKEDQNDNKEEEEDITKQRMFINLNSNSFLLLLPDSISPFKFSKYSQIQRFKLSSDNSSSLLILDWINSGRGGGGGGNDKNEEIWEMDFYNSINEIFLGNKIIMREKMLLDNSNSNSKIKQEEGLSKIANSLKPYNVYGTVLFTGPHLIKLMNLLKVRSDEFRQFQIKQPQDLIWSFSEINSEFGAGIIRVAAKEIESARDWLRETFTQGGVGDLVGEAIWPRCI</sequence>
</entry>
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    <accession>A0A1B9I7T9</accession>
    <name>A0A1B9I7T9_9TREE</name>
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        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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        </lineage>
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    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
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    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="KV700115">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="kpin:30170702"/>
    <dbReference type="OrthoDB" id="21225at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.40.50.2300">
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    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF72">
        <property type="entry name" value="OSMOSENSING HISTIDINE PROTEIN KINASE SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="691"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="1333"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="31"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="407"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1120"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1251"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1120"/>
            <end position="1134"/>
        </location>
    </feature>
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            <begin position="1185"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1259"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1279"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1292"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="1392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF51618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC70842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1469" mass="164284" checksum="FD9CF89A26E8BBEB" modified="2016-11-02" version="1">MSSNDKIPFSKIAPSSDAEWAEALKCYARDREYQKEESSSNVSKHKIKDIHRSANTHWSASQSPPTQDVTFQPLKSDETNSKPPLVHHGHSDDSMDAGIGGIPYKKPENIPGPFKCIEAATEDVPSIHQYDNQPSNTHWHNRQYSTNGEQSINFSKNMAAIEPIPLAFDTARTIPQERLESDFNSDDFRSADKERKRMQQFYEKNGWLPGPVPNKLNRLKRRRAIRRLGLIGEEEDGRKSVLSKYAEMAELVFDVPRALVSVIHDEVEFAYSADINKKPISRPTQQAACSHVIDIHDGDCWIIADCTNDWRTRDHPLFQDKLYKFFAAAPLRYHGKDGSIIDFGSLNIYDTEPRYTFSQRERSLLLKLSNMLVYQLATLQSEYMAKRSTAMYEASISFLRRSFVSNPSETQSRRGSRRVSSSHASPSPPQRLPSPRKKMQPPNVSTSTAVASKLGPWDDKDARRLAIQSDRTLFNDAAETLKGLLNADAVVVLNMEDYQLFIKKSSSVSSHALEGKKGKDRIRSKEKIIIDYMNGDPWPEDIEPVINYIGKQSSQAEILGSAFSKGDIELSDQFNFDVPDVEDTLGEFLKTYLSKRQFWWDREENTDSLSGKIMQLMPQQAQTALGTTFLGHDGKIKFVMFATWNTPPSSLVDSSMIALPFVWILGGCLMAALAMKKIRALEQSQISYSNLQAHELRTPLHQILAITQLLRSTMSDLAETNSSSTPSKLTSTEQIRDMMPFLDAIDTGGKTLHGIVDNILSFLDLKGRESSRSFGDAALLAAPSGTQTSLETMLEEILENVMLEDQKSRKANGQPDVEVETIFEIIPPLLGEQVSEDAGGALRRALTKILANAYKFINNEGCVEIYVDDVVDLLPPEGCEDIALTRLISIIIKDDGRGMDPAFVNDKLGQPWAKEDSYITGSGLSVHLAYRIIDLMGGCMEITSAQGAGTTVQIDVPLPLRSIPFTDLHNSEPGSRRESTDSIRQLTVNQDSINVGRKVYLLGWEGSRINVVGKALNRQYTKLGCEIVNDISQAQLIIAFGKVEEDLELFKRKIYSQNLKTDNLVYLTSENHKANSEVLKLQDEKQYKVRRFKRPTNPSILRETLFPNHSKRLQDTVKEENNNHDNNDFKRSDSHVPSPTNEQADLEMDSGTINTPHLMSPNGDDMGEPFDSKGIKGLYHHNGSRESNQSTANRENSLAQISEASRDKLDKDATSTKSIEDVIADLSLGIYSPVDVNPQQLTADRDVDANEGVTKEQSTHNLQINNLQQGRSQVKTGDSSNSNLLPNNNTSVASGKDTQTDTVGQPSNPSICPTKSVNKNNHISLASNPNKVKVLVVEDNKINRTILVKILSSTLSSIIEVYEAEDGNYAIEIFKKLISNNNNNQPIIVLLDINMPKKDGFQTCLEMRLIEKELKIKSQIIAVTALGSEEEKRKGLVECDMNKWFIKPCSKSTIIEIVKQAYNEISLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I8K1</accession>
    <name>A0A1B9I8K1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_02624</name>
        <name evidence="2" type="ORF">I206_105084</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC71131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013127.1">
        <property type="nucleotide sequence ID" value="XM_019154387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I8K1"/>
    <dbReference type="GeneID" id="30170993"/>
    <dbReference type="KEGG" id="kpin:30170993"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCF51908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC71131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="139" mass="16249" checksum="7BB272C7981EE6EE" modified="2016-11-02" version="1">MTTKQSIMKSNSESPNLQSILKKTKSPTFTSKKKVKFNLPIIESNSKSCSNWPIPFPDNFNTNINYTSILEYYPYQSKIVKDNYDSWELINPDETTTINENSTIGQYFQCIISKLLPNWFLEKEIPDMMQDTEFLQNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I8K3</accession>
    <name>A0A1B9I8K3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_02519</name>
        <name evidence="4" type="ORF">I206_104980</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="OCF51803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1B9I8S1_9TREE</name>
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        <name evidence="10" type="ORF">I206_103737</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
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        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1296096.A0A1B9I8S1"/>
    <dbReference type="GeneID" id="30169631"/>
    <dbReference type="KEGG" id="kpin:30169631"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF12">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
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    </dbReference>
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        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
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        </source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="600" mass="65029" checksum="D36EA696D000749A" modified="2016-11-02" version="1">MAQEGSFTQFNDVEKKGAYTGAGVEAGHSVSVDPAQDVYYDPSKESLMTRLGLNLESFKRAPGTTRGLVAHGDIPPEYLQHDNPLLQQKMKPRHLQMIAVGGSIGTGLFVGSGSALGNGGPAGILLAWIIMGVMLINVTQALGEMAILYPVSGGFYTLASRMIDPSFAFAMGWNYVLQWAVVLPLEITVAGSTVQYWTDAVPLAAWITIFFVVIIIASALGTLGYAEEEFWSSCLKLLVVVMYIIIGIVCICGGGPAGGDFDTYQGARLWHEAPGAFPNGFKGVCAVFVTAAFSFAGTELVGLAATETPNPRKTMPSAVKNTFWRITLIYVTSLTIVGLTIKSDDPDLYNGSGSDISPFVILMDRARIKGLNHLINLTICISVLSIGLSCVYAGSRTLTALAETGYAPKFFTYIDKSGRPLYSVLALLVLGPLAYINCADVGGEVFNWLVALSGLSTLITWLSICITHIRFRKAWKAQGHSVEELPFKALGGEYGSWLGTILIIIILIAQFYIGLFPIGGVESAGERAESFFLSYLAAPIMILFYVVGYAWKRGTPRKASEIDLDTGRKSWLTVEEMRIYRAERAAAPFYVKVYRMLFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1B9I9G8_9TREE</name>
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    <gene>
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        <name evidence="3" type="ORF">I206_103587</name>
    </gene>
    <organism evidence="2">
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
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            <authorList>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
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            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Murphy C."/>
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                <person name="Saif S."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
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                <person name="Imamovic A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
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                <person name="Young S.K."/>
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                <person name="Gargeya S."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
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    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013496.1">
        <property type="nucleotide sequence ID" value="XM_019153335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I9Z0"/>
    <dbReference type="STRING" id="1296096.A0A1B9I9Z0"/>
    <dbReference type="GeneID" id="30169933"/>
    <dbReference type="KEGG" id="kpin:30169933"/>
    <dbReference type="OrthoDB" id="10248581at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06926">
        <property type="entry name" value="RNAP_II_RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.10:FF:000011">
        <property type="entry name" value="Related to DNA-directed RNA polymerase 13.3K chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037685">
        <property type="entry name" value="RBP11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF16">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="6">
        <location>
            <begin position="31"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCF52277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC69492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="160" mass="17960" checksum="0D039790F61684EE" modified="2016-11-02" version="1">MNQPNRIDSWLLQDDEKPLTITEDPKIPNAATVLLRKQDHTLGNMIRAQLLLDPTVLFAGYKVPHPLENDIIIKIQTDERSNPADALKRACHLLIRQTVHIKQQFMDQAKNIEMGMGPDQALAGVNNGNYDPYSDGLGREGNTIVGGQVRDNNQTDVYDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IA53</accession>
    <name>A0A1B9IA53_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_01758</name>
        <name evidence="12" type="ORF">I206_103236</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013687.1">
        <property type="nucleotide sequence ID" value="XM_019153526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IA53"/>
    <dbReference type="STRING" id="1296096.A0A1B9IA53"/>
    <dbReference type="GeneID" id="30170127"/>
    <dbReference type="KEGG" id="kpin:30170127"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF68">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="441"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="476"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="53"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCF52468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC69298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="534" mass="59262" checksum="0ECCD163504BB430" modified="2016-11-02" version="1">MADLERVESKKDDIYVSSAEADKMRNELEDHTTAFAGLTRIQAIRKFWRASLFCMITAFGVIMDGYQTSLPGSVLANAGFIKQFGTVVDATTGKISVNAQYISMWSGLAYLCQFIGNWSGGFISDRFGRTYTLYALTIVFTGGLITEIVARDYKDWLAAKMLMGLGQGLTQQGVLTFISEVAPTQLRGALMSTYGWSYALGQLFVSIALNALEMTDPTNYLKAIYSEFVFLGLWIIALPFLPETPWYYARKEDEVKAKKVLGKIYKGVEGYDIDREYNAMLVEIQEEKYKSKSNSEVALKDIFMGPHLRRTFASLFALVMQNWSGSPIIFNYTTYFLQQAGLPKPFQASVIVYCILLFSLMVSFYGIERLGRRTLILSGGVACTIFNLAIAGLGFAHKSDSVDNATLAFICLWVFMYAFGFAGTGWTCAAEIATPRLRAKTTAFAASTNAISGAIFNSVVPIMLSTTSRNWGVKTLFMFAILGGIGTVINFFLLPETKGRTFAELDELFDLKIAPRKMKAHVTSIEESGLKNHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IAL4</accession>
    <name>A0A1B9IAL4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_01941</name>
        <name evidence="3" type="ORF">I206_103055</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013867.1">
        <property type="nucleotide sequence ID" value="XM_019153706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IAL4"/>
    <dbReference type="STRING" id="1296096.A0A1B9IAL4"/>
    <dbReference type="GeneID" id="30170310"/>
    <dbReference type="KEGG" id="kpin:30170310"/>
    <dbReference type="OrthoDB" id="2560085at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF52648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC69119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="221" mass="23404" checksum="FCB3D41343D1BB4D" modified="2016-11-02" version="1">MRAGIDSIIYLITCALSVVCVAACGNSLHRRNINIGEQSAASLARGIRLILSTNDLSGAGYALSVGAGGIAVGTLILFLHSLRILPMTRFLRKIFFLSPLMLVINTLLVAASGIAVTYIGRHGTTSIAAFIGTNQLPESVVRAQAKAQGVPLDYWSNGYVKFMVASPWPVLPFALASTYLAYKAYKVERPSAQTSGIAANDIGVNRTVSGPNDKAEVQHIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IBE8</accession>
    <name>A0A1B9IBE8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Vesicle-associated membrane protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_00283</name>
        <name evidence="13" type="ORF">I206_101043</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF52982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014201.1">
        <property type="nucleotide sequence ID" value="XM_019152063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IBE8"/>
    <dbReference type="STRING" id="1296096.A0A1B9IBE8"/>
    <dbReference type="GeneID" id="30168652"/>
    <dbReference type="KEGG" id="kpin:30168652"/>
    <dbReference type="OrthoDB" id="190375at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15874">
        <property type="entry name" value="R-SNARE_Snc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000004">
        <property type="entry name" value="Vesicle-associated membrane protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016444">
        <property type="entry name" value="Synaptobrevin/VAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45701">
        <property type="entry name" value="SYNAPTOBREVIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005409">
        <property type="entry name" value="Synaptobrevin_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="44"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="13"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCF52982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC67136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="130" mass="14013" checksum="9BF6344193B67DFD" modified="2016-11-02" version="1">MYVQLSTVSAEPYDPYIPAGSSAPQPGGGVGGSGAQGGGQQNKKIAAIQQQIDETVNTMHDNIQRVAERGERLDALQDKTDTLAVSAQGFRRGANRVRKQMWWKDMKMRIIIGVGIAVLIIIIVVPIVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IBH8</accession>
    <name>A0A1B9IBH8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_00043</name>
        <name evidence="3" type="ORF">I206_101280</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="OCF52747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC67372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019151828.1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="59"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF52747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC67372.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="214" mass="24043" checksum="03CE97AA2CFE5335" modified="2016-11-02" version="1">MPSHSLIQDGPNGPYIQLPNHNLKLTLWQETDVNDAVALFNHPDIGRWSITRPYPYTTQDYKYISSAIPSLEKLALSLINESSPDLKSISTAPIFPLSALRNNKGKVVGFCSIGYSQKEKGSWEIAYDLHPDLQRKGIATVMVKSILDFVKGLGVERVIAFVESTNIPSASLLRRCNFTFVEHKSQNWAEENGCGSRLLNWYEIILQLEPIPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IBJ8</accession>
    <name>A0A1B9IBJ8_9TREE</name>
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        <submittedName>
            <fullName evidence="11">Solute carrier family 25 (Mitochondrial carnitine/acylcarnitine transporter), member 20/29</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_00099</name>
        <name evidence="12" type="ORF">I206_101224</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
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    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
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    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="MCP_dom_sf"/>
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        <property type="entry name" value="MCP_transmembrane"/>
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    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
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        <property type="entry name" value="CONGESTED-LIKE TRACHEA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="17"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="115"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="222"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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    </evidence>
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        <source>
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    <evidence type="ECO:0000256" key="8">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCF52803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC67316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="312" mass="32759" checksum="8FF801FA05D6F0BF" modified="2016-11-02" version="1">MSDEGSDIELSSSKQTVDPVKSFLSGGFGGISCVLVGHPFDLTKTRLQTASPGTYTGAVDVVRKTIAQDGIRGMYRGITPPILGVTPIFAISFWGYDLGKRLVYSFTPDRTSQSLSITELAIAGGFSAIPATLVAAPAERVKVLLQVQGQGGSSMYNGPIDVVRKLYAEGGLRSLFRGTFATLARDGPGSAVYFATYELLKKQLSSAPETLPNGDKAPAPPLSLPAIMAAGGTAGVAMWSLAIPPDTIKSRLQSAPHGTYTGFMDCARKLIAADGVTALWKGFGPAMARAFPANAATFVGVELSLKAMEKMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IBQ9</accession>
    <name>A0A1B9IBQ9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alcohol dehydrogenase (NADP+)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_00330</name>
        <name evidence="6" type="ORF">I206_100996</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014248.1">
        <property type="nucleotide sequence ID" value="XM_019152110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IBQ9"/>
    <dbReference type="STRING" id="1296096.A0A1B9IBQ9"/>
    <dbReference type="GeneID" id="30168699"/>
    <dbReference type="KEGG" id="kpin:30168699"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000034">
        <property type="entry name" value="Chromosome 7, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="17"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF53029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC67089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="329" mass="36880" checksum="12BC6D63959A876E" modified="2016-11-02" version="1">MTQTHFTLSNGKKIPSIGLGTWQSAPGEVAKAVEYALKNGYRHLDCAWAYGNEAEVGQGIKASGVPREEIFVTSKLFELHHHPEHVPLAIKDTLKNLGLEYLDLYLLHWNINLEVDAPAGVLPRNEHRVKGSSGKFKLDVALSDDVTPTWREMEKLVDQGLVKSIGISNFNINRTKKLLKEARIKPVADQVELSIQNPQPELVAWLKKNDILPQGYTPLGGTGKTNLRDNEQIKKIADVHGVQTANILLSWLVSRGINPLPKSVTPERIANNLKLVDLTKEQLEELDALSKSHPQQRVCDQSDSFEPTYDIYQENDPEFSDKVQFAKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9ICA2</accession>
    <name>A0A1B9ICA2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_00358</name>
        <name evidence="10" type="ORF">I206_100968</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal RNase P protein component 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014276.1">
        <property type="nucleotide sequence ID" value="XM_019152138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9ICA2"/>
    <dbReference type="STRING" id="1296096.A0A1B9ICA2"/>
    <dbReference type="GeneID" id="30168727"/>
    <dbReference type="KEGG" id="kpin:30168727"/>
    <dbReference type="OrthoDB" id="124041at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.210">
        <property type="entry name" value="Ribonuclease P/MRP, subunit p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00754">
        <property type="entry name" value="RNase_P_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016848">
        <property type="entry name" value="RNase_P/MRP_Rpp29-subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036980">
        <property type="entry name" value="RNase_P/MRP_Rpp29_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023538">
        <property type="entry name" value="RNP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023534">
        <property type="entry name" value="Rof/RNase_P-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002730">
        <property type="entry name" value="Rpp29/RNP1"/>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1B9ICU1_9TREE</name>
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        <recommendedName>
            <fullName evidence="4">G domain-containing protein</fullName>
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        <name evidence="6" type="ORF">I206_100554</name>
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        <lineage>
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    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">CBS 10737</strain>
        </source>
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    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="6">CBS 10737</strain>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in 20S proteasome assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the 20S proteasome chaperone.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the PSMG2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014685.1">
        <property type="nucleotide sequence ID" value="XM_019152547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9ID56"/>
    <dbReference type="STRING" id="1296096.A0A1B9ID56"/>
    <dbReference type="GeneID" id="30169138"/>
    <dbReference type="KEGG" id="kpin:30169138"/>
    <dbReference type="OrthoDB" id="10260712at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="entry name" value="PAC-like subunit"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016562">
        <property type="entry name" value="Proteasome_assmbl_chp_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12970">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12970:SF1">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010044">
        <property type="entry name" value="UCP010044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00019186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF53466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC66652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="264" mass="28528" checksum="D12EB38134381679" modified="2016-11-02" version="1">MTSFYPTENFSSASFQKATLILPAVSLGNVPQLTNDLLIKSLGLKRIGYVGKGDTVVPFSGKGDEGEIVTGGLEVYGNQGSELYVIQQRSPVLKTKKDEHIALIREFVISNSFGSVVILTSLDAANQDDAQLLTPHQRILPPSSIPHPLIQNLEKSLPPLQLNISDNIQLSNPSSIYPPFLPSAGLTRRLLSALQDTQTPHGAISVWCVEGDNRNDAISFAQLVLSLLKIDDKVQLTEPDSWKGLFGTTEGWSGGSGQDSELYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IDH7</accession>
    <name>A0A1B9IDH7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 14">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="10 14">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I206_00767</name>
        <name evidence="17" type="ORF">I206_100558</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10 14">
            <text>6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10116"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10 14">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10 14">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="10 14"/>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014683.1">
        <property type="nucleotide sequence ID" value="XM_019152545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IDH7"/>
    <dbReference type="STRING" id="1296096.A0A1B9IDH7"/>
    <dbReference type="GeneID" id="30169136"/>
    <dbReference type="KEGG" id="kpin:30169136"/>
    <dbReference type="OrthoDB" id="434986at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000002">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.320:FF:000002">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000007">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006113">
        <property type="entry name" value="6PGDH_Gnd/GntZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006184">
        <property type="entry name" value="6PGdom_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00873">
        <property type="entry name" value="gnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006765">
        <property type="entry name" value="PRK09287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000109">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00461">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="5 10 14" id="KW-0521">NADP</keyword>
    <keyword evidence="6 10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 10 14" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase C-terminal" evidence="15">
        <location>
            <begin position="182"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="13"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="36"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="78"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <begin position="132"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <begin position="189"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        </source>
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        </source>
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            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF53464.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="492" mass="53719" checksum="6BEEC34D1DC063B1" modified="2016-11-02" version="1">MASEQLADVGLIGLAVMGQNLILNMNDKGFKVVAYNRTTSKVDAFLANEAKGTNIVGAHSIQELCSKLARPRRIILLVKAGQAVDDFIAQLEPHLEKGDIIIDGGNSHYPDSIRRTHELEAKGLLFVGSGVSGGEEGARNGPSLMPGGSDAAWPHIKEIFQKTAAQAEGEPCCDWVGETGSGHYVKMVHNGIEYGDMQLIAEAYDILKRGLDLEETEIADIFTKWNTGVLDSFLIEITRDILKFNDTDGVPMVRKILDKAGQKGTGKWTAIDALDNGMPLTLIGEAVFARCLSAVKDERVRASKVIAAPERQPFQGDKQQFIDDLEQALYASKIISYAQGFMLMREAAKVNSWHLNNAGIAAMWRGGCIIKSVFLSDITAAYRENPELENLLVSPFFLSALSKAQAGWRRVIAQSTLWGIPIPAFTTALSFFDGYRTETLPANLIQAQRDFFGAHTFRVVPGMGNDHLKEGEDVHVKWTATSGNVSSSTYNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IDI0</accession>
    <name>A0A1B9IDI0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphatidylinositol-specific phospholipase C X domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_00842</name>
        <name evidence="3" type="ORF">I206_100485</name>
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    <organism evidence="2">
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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            <end position="266"/>
        </location>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC66582.1"/>
        </source>
    </evidence>
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    </evidence>
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</entry>
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    <name>A0A1B9IE15_9TREE</name>
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        <name evidence="5" type="ORF">I206_100355</name>
    </gene>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="30169339"/>
    <dbReference type="KEGG" id="kpin:30169339"/>
    <dbReference type="OrthoDB" id="7763451at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343:SF10">
        <property type="entry name" value="RNA-BINDING REGION RNP-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SERINE/ARGININE-RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="32"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="267"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF53664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC66453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="302" mass="31238" checksum="F6D237D93FF24BC5" modified="2016-11-02" version="1">MSAPQESVGNQGVPAPSTSSTIGGPATIVPGYTIHVNGLATETTEDKLHDFFSFCGKLVSVKKIGNEADITFEKLSAMRTSLMLNGGTLDGAHLEVTSASDAEPKTASVLPTGASGSTAIGATEGGISQEDKPRAAIVAEYLAHGYALGDNIVQKAIDIDNKQGISARFLSFFNSLDSTVGNKVVGENKTVTGKINETAAAGVAKAREVDQHRGFSAKFHDYYSKVFGTPLGQKVVQFYTSTQKQVLDVHEEAKRIADEKKANAHPIPPVASVADEPGSAVGNTTTQGGALPTAPGAVALGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IEE8</accession>
    <name>A0A1B9IEE8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_01220</name>
        <name evidence="7" type="ORF">I206_100107</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019015132.1">
        <property type="nucleotide sequence ID" value="XM_019152994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IEE8"/>
    <dbReference type="STRING" id="1296096.A0A1B9IEE8"/>
    <dbReference type="GeneID" id="30169589"/>
    <dbReference type="KEGG" id="kpin:30169589"/>
    <dbReference type="OrthoDB" id="2563011at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628553" description="Peptidase A1 domain-containing protein" evidence="4">
        <location>
            <begin position="22"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="5">
        <location>
            <begin position="47"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="507"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="722"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="507"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="519"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="530"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="722"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="735"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCF53913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC66206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="768" mass="83972" checksum="09D4C6698BD59B45" modified="2016-11-02" version="1">MFCDLPVILAVFSVVVRHVRGDDRTDTQRIGTEYTSMPLYRSGAGTNVMSANVGNPPTELKLTCSTNVDFFVVAATGCEECVENANLLDVSRSQSISVTNDDLAYVFSYPSGSSSTLSIAGRFANDIILDERGDEATPRPIVLAAAVQSNDPRANLDGVDAKLSDGSAGFWGMGVYQDRKANSMIPSMIIADNDGSPGQLTSYTVGFQINNFSTNTDDLAGTIHWGAVPSDAYQGNFNWLDVDLTMGGSWAFGVDRLRIEGEIIGLDNHFGTIDPGFDSIYLPTAIAERIFAKVTGAERDLVDTTRWNLPCDASIDLKIIISGTQYAIDPTALVRNRDAAGRTCWSSIVAWQNGSVPETNGEVRLGTPFMSGVYAALYYSDAAQYVGLAGKPNSVNAANLYSRDEGHANKKLAGILIGTLLGVLIFGFILCYARNRSSFQSIWYRALRRQQRAQMNAVVRGATMPPPMMPIVPIPMGGPMIPRGPPPMMAQMGMLPPQSMMGMGRMMPPPPPYQPPMAPQQYQQQQQQPLLGNQAHTSPQMTMPMTVQPDQTGFYSPRLQHTSPPKSNYLPLPWKGSKGRGSGKYAEPLSGGSRVHFGPSSARHTRSISGSGASVNEFGSYGRGPEGRHDRQNGFIREYQNLPPSHVHTPQYDHHQSQHHGGYQNEESLPPLAEVPEQEEYIPYPHQQQIQHQNEKKKYFSWKSNASSDGGGKGIYAPVGVNTSIQTGTNPNIDEQARRSWWNRDKNGGWKERESIGTPKIKRGLGWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8KXR8</accession>
    <name>A0AAJ8KXR8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_100711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058359.1">
        <property type="nucleotide sequence ID" value="XM_070202258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8KXR8"/>
    <dbReference type="GeneID" id="30168985"/>
    <dbReference type="KEGG" id="kpin:30168985"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC66804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="232" mass="26689" checksum="C80B7B413F4444A9" modified="2024-07-24" version="1">MATSFVGRGMWPKIWLWICKGWVYIVAVGCLIMNLIVWIIIFIENTKCYTEKMDQYLGNDQRVYDRIDGDPNARYVANTNIPKHLGGPVFAAAFDVAMWMFILIAICADLFWRIPFCRRILESMWTNGLYYSPEQKFIDIEFFFLVASAFLKIFIVVATGSQTYTGLYPKQDQPQLDTPLFCLYATLCLAISIPFTIIALFYILHGMKMKEYKDELAAAEAAAKEKKKKESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8KY34</accession>
    <name>A0AAJ8KY34_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_100487</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8KYZ0</accession>
    <name>A0AAJ8KYZ0_9TREE</name>
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        <recommendedName>
            <fullName evidence="2">Splicing factor subunit</fullName>
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    <organism evidence="3 4">
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        <lineage>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
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                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
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                <person name="Nowrousian M."/>
                <person name="Sun S."/>
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                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC66288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <sequence length="86" mass="9755" checksum="11E825E5E7244B99" modified="2024-07-24" version="1">MSELRYTANTQLEQLHSRYTGTGHADTTKYEWLTHQHRDTLASIIGHPPLLGYVSIADGECQARERFELIEKMVQPCGKPPGKTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ8KZJ0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
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    <gene>
        <name evidence="3" type="ORF">I206_100701</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
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            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SLR1338 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="233"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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        </location>
    </feature>
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        <location>
            <begin position="104"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="449" mass="48215" checksum="9DFC0348FDEBBEFC" modified="2024-07-24" version="1">MGLASKLAAAQAGGNTNPYGGAAPAPAQQQQPQQAAQQSYGAPQGQYGQPQQQQQYGAPSGPPPTPGQRPSSGQYSSPSGPPPGQYGQQGQQQYGSPAGPPPGQYGQQQGQYGQQQGQYGQQQGQYGQQQGQYGQQQQGIPGQQYGNQPPQYKPPQGAAAGAPAPGGGPNAQAILQSLTQCVQEQKIQAFYPPGSLDAIAQRVAASGVLSKIASEWRMPLELASDLVKLSLFDVILYVDDSGSMAFEQGGERIDDLKLILSRVAYATSLFDDDGIQVRFMNNRLEGNGIRSEQDALNLVNQVKFSGLTPLGTSLWQKILQPLVLGPAQQNRLQKPVLIIAITDGTPAGENRDEIFKVILRADNELKRSRYGPDSVSYQFAQVGDDMKAMKFLEELDNHPQVGSLIDCTSNFEAEQAEMMRKSGIDLSPEMWLVKLLMGGIDDSYDAKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8KZN2</accession>
    <name>A0AAJ8KZN2_9TREE</name>
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        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
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    <gene>
        <name evidence="8" type="ORF">I206_101300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="30168392"/>
    <dbReference type="KEGG" id="kpin:30168392"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="539"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC67392.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="598" mass="67596" checksum="100A2AFEB4EEE8D8" modified="2024-07-24" version="1">MSAVKSGGSSSPRDDNSVKSTIDENTLPEEYHLGNDRKHSVKVEAAPLAIGVSSAEVDKAESALGSAILRALKLRPPLPKDAPDAIATQPSIWDGEDVDELKARYIRSDWENIEAFDPNFRWTVKEEHEVRRKIDWKIMLWACVMFSALNIDRGNISNANSDGLLKDIGLTQADYNLGNTLSKLFFLIAELPSQLISKRVGPDRWIPIQVCIFSIISGAQFFLSGRSSFLATRILIALFQGGFIPDLILYLSYWYDSRHLPIRLAWFWMSSNICGIITDFLAVGFLKLRGLHGYEGWRWLFLFEGIITLAIGLAGFFLLPTSPAKTKSKWFPKGYFTEKESKIIVNAVIRDDPGKGGMHNRQALTLKMIWNCILDYDMYPLYALGLLFGIPKYPVGNYLTLSFKELGFSTIQTNLLSIPYEVISIFTQFLITAISELSNNRSFVAAAEDIWLLPCFIPLITLPDPINPWSYFAIETVLLSYPYTHAIQVAWTSRNAGTVQNRSVSASLYNMFVQASAMIGANVYQASDKPRYKKANKGLVGLLVFNVVILYPGTWAYYKWRNRTRERIWGAMSEEERQHYLKTTTDVGNKRLDFRFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L049</accession>
    <name>A0AAJ8L049_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">General transcriptional repressor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_100985</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CYC8/SSN6 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_070202308.1"/>
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    <dbReference type="GeneID" id="30168710"/>
    <dbReference type="KEGG" id="kpin:30168710"/>
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        <property type="component" value="Chromosome 1"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:transcription repressor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
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    </dbReference>
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        <property type="entry name" value="Corepressor-Demethylase"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017:SF1">
        <property type="entry name" value="LD02225P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
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        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4 9" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="130"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
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        </location>
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            <begin position="278"/>
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        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="350"/>
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        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="384"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="465"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1068"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="581"/>
            <end position="590"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="824"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="873"/>
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        </location>
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        <location>
            <begin position="919"/>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
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        </location>
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        </location>
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            <begin position="1025"/>
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        <location>
            <begin position="1070"/>
            <end position="1087"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00061082"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC67078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1087" mass="117630" checksum="A2A590245CF1E580" modified="2024-07-24" version="1">MPDARMSHSSHHHHHSHSSHPYPSHGPPAGYPPSSSHSHSPYPQSGHHHHHSSRHVSNGPPAPVVVGGPPHPPPMTMAGPPPDAVGPPPVVAVSNGHGHPSGPGGSISPAARAAKEKMDNLLAQLANANENTWMLIGAVAEGMNNPDRALTAFENALRHNPSSVLGLNAVASIARSRDNFDKAIEYFQRILNINQENGEVWGSMGHCLLMKDDLPKAYTAYQQALYHLPNPKMDPNFEKANEIYFRLGIIYKHQRKFPASLDCFKYILNNPPRPLTTWDIWFQLGHVYEQDRDYEAARDAYMRVLSHQPDHAKVLQQLGWLHHQPGAPFADQDKAVAFLTKSLETDGTDAQSWYLLGRAFMAGQRYNKAYEAYQQAVYRDGRNPTFWCSIGVLYYQINQYRDALDAYSRAIRLNPYISEVWYNLGSLYESCNNQITDAIDAYSRAAELDPTNPTIKQRLSILQTHGNAPLPPAPGPVDVHPSQYSATPTGQHPAGTSPGQSPHGPPGQLPPADGSAAGRDLPPPPPGSEFGRPQSPGPFRGGPVPPPLALVDESRGSMSRHAPLAPIEIERSERGGEPPFNGGGGGGGGRFDPTSRQHMDGPPSPRRRDPFGNGPPPAASNHAGYPPSGYRGDRERDEWERSRRAPPPGGPIDVRGPSSRMQDPHADPRRQPSPRIPADFRGNDYAPRGGDHPFPSAYPYDHHRGSFGADPRYDPKREAEEARRRDDRRFDEREAARHGSVTRDLRVEENVRVPSPAPSTGSKAGSKRRSAEEKAGIAKRAKDEKPPSKKSSGDSAKKDKSRSSGFRASLDGADSRGVSPRPATVTSSPSASVRSTPHQTPQKTIPSRTVDEDYDEGAADALMTLHGDRPPTSKDSSVRNGSPASHTSPAISSGLGAKRLEPPSPTSPAGNNKKPKAETSTSPPAPAARRTIIEVLNTPSIGSPLPRSTAPEEKSESAEKKVDDTENVLPTEDKPAEDAPVEKSPAPTTQAQAEEEADQDKTTEEQEKESSRPPTPPLPSPPAAKAPEPIAENATEVDGDVQMGEPEPQAQVSTVEKATPEDAVVTAAEVTEEGEVKEDEPVEEAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L0Z8</accession>
    <name>A0AAJ8L0Z8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_102097</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019158509.2"/>
    </dbReference>
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    <dbReference type="GeneID" id="30175179"/>
    <dbReference type="KEGG" id="kpin:30175179"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008413">
        <property type="term" value="F:8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042262">
        <property type="term" value="P:DNA protection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03427">
        <property type="entry name" value="NUDIX_MTH1_Nudt1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43758">
        <property type="entry name" value="7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43758:SF2">
        <property type="entry name" value="OXIDIZED PURINE NUCLEOSIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="6">
        <location>
            <begin position="54"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC68174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="275" mass="31799" checksum="106C1249B13FB15C" modified="2024-07-24" version="1">MIDVERPSEYERLDSEESEIPHEFRHLRNLRSPFACRAPSEGWEAMDGDDVTRSPVEYTLIFPVDLKQSQVLLGLKRRGMGYNLYNGFGGKVEKGETVWEGAIRELQEETGLIANDDDFYYKGCLYSSRPLSPPPSTETCIIKIHFFACVAWRGQAVTTEEMIPEWFPLPSLDSPELHRIPVDQMLRQWPEASFYLLPILDSILHNKRSDIFLSRINYRFIRELDVPNNLPAIEGNTIRKSRPSQHNDDLAERLCSWWMSLSPMSLSPFADSRML</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L1F7</accession>
    <name>A0AAJ8L1F7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CSC1/OSCA1-like 7TM region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_101511</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058501.1">
        <property type="nucleotide sequence ID" value="XM_070202400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L1F7"/>
    <dbReference type="GeneID" id="30174885"/>
    <dbReference type="KEGG" id="kpin:30174885"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF5">
        <property type="entry name" value="RE44586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="723"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="766"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="809"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="848"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="567"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC67601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="908" mass="100012" checksum="7BFCA6A80681AFB9" modified="2024-07-24" version="1">MTTTSIYNPIITTPPLLRTSEQSNYQNKRHFYLCGDEILSWESEWYTASFFTSDRSSFDKAASTGPVQPPTSIYQNVPACAAILSSEISATSSLTNGRIITTETLSTYISNGRTFVSTITRTTNIPLSTSSPLATVSATTSLSIIPSSTTTSPASAITDPSSINTCAGGWDWQGWGVVAGLGSGVILGTLLWILWAVLRKKLPGIYAPRTWAIPSESRPPKWTILAFLLPFSHPSQSWTEGSGSLSVLFAGLKLAGMLSILALAAILPLLLVGVPCLSETSPTNSQRGRLGTLTDFSLLPLLNALDPSPDSSATSHTLLQMLETRSLTSTISPAISNARIRLIIILVILAVLACGGGLFVIARTYAGLIRRKTDFDNKICQKMEMVYIRANDAPGWKGMTEEGVRNLLKDYSAKMKGGNEKEIEIVGVFAIPDTTELRNKVKEREEALMELEVAETSYVSSFQLTHRTTSGGILEALDWNKNDPANQSAHNSSPTRQTPPDDFLAPKRFYRIPTATQPQSRERLDVPMPPNLGEMQGEPPDSRFKEINRDSAMYGGRFDIGQRIKMDPAGEWVPDPSPQSEETSPLGVTPESTPEDPLSVNPILLKPTSPNERSQIPTRSSHRVSVIRNGDASHSRLADHYATIRRCRATFKEMNREIDELQRRKFAEIATTNSNLVGWVIVGKGVRWLPHAEIIEGFTREDFLWHNGVYQTNEKQFWAKVTILAMVLGIILIPVLGLTVGTAPGFDHYLGLMKPLAKSDGLGSGVVEGLVPAIFLTLVVVAIVYFTDEFSKDVRYISRSRQRSLAYKAVFYLLLLVVVIWTILVASLEFAVQGFTTNVQKARVVGDGAIFSTWFTFVLLLNLAFILPALYLLQFPRLLRYLKSRKKAITPRQKFRLLSPPLTIQLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L1T6</accession>
    <name>A0AAJ8L1T6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Anaphase-promoting complex subunit 4-like WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_101725</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the THOC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058549.1">
        <property type="nucleotide sequence ID" value="XM_070202448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L1T6"/>
    <dbReference type="GeneID" id="30174677"/>
    <dbReference type="KEGG" id="kpin:30174677"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040132">
        <property type="entry name" value="Tex1/THOC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22839:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22839">
        <property type="entry name" value="THO COMPLEX SUBUNIT 3 THO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="383"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="6">
        <location>
            <begin position="429"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="267"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC67811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="505" mass="55379" checksum="3A7503F3946509E9" modified="2024-07-24" version="1">MVNEGGQPYRPDFFPIAQPAARDLLRPAFGRSQDIRGGNVKHVRSVAWSCDGRRVATGGEFKEILVWDTKLNIEARGSTPLPSSSKTNVHNGHVGSIAWSPVDPHILVSGDKGASAGGVIAVWDVTSNSSPIASFKIPGDVLHISFHPSGRHFAVVCPQRNKDEVFFYWRHPIDGVEKWERRDDVALGGALMDFGAEEINSLRFDNSGKLVCAVSNDGSINAWIYPTQLQAQQEQMDDTLEPRVIKSGPSTTPSTPKLPVEVENAEILKSREGSREGSPENTREGKETAEEDTEINEEEQGKVNQEGEEVKQTIVAEGDEYKQTEIEGSEDVEMKEPAQEMEALPTTSAAPSRQPTPPLPPNQTLIKPAEKKKAGQLQRFRHAVCHSASLLSLAFDPQGKYLAVGGQDALLSMFDTRNWICERTFDVCTSAIRHIAFSHDGEFIALGGDDSYIAIVSVYSGALVAKLPVYGMVSSIAWHPKTNWLAYSYSGKVASPIWHIVHQET</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L5A9</accession>
    <name>A0AAJ8L5A9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vacuolar protein 14 C-terminal Fig4-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_104821</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VAC14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059102.1">
        <property type="nucleotide sequence ID" value="XM_070203001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L5A9"/>
    <dbReference type="GeneID" id="30170729"/>
    <dbReference type="KEGG" id="kpin:30170729"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070772">
        <property type="term" value="C:PAS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026825">
        <property type="entry name" value="Vac14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021841">
        <property type="entry name" value="VAC14_Fig4p-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023:SF0">
        <property type="entry name" value="PROTEIN VAC14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023">
        <property type="entry name" value="TAX1 BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12755">
        <property type="entry name" value="Vac14_Fab1_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11916">
        <property type="entry name" value="Vac14_Fig4_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="5">
        <location>
            <begin position="82"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein 14 C-terminal Fig4-binding" evidence="7">
        <location>
            <begin position="745"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="193"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="333"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="511"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="982"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1090"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="376"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="511"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="559"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="605"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="988"/>
            <end position="1000"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC70869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1117" mass="122104" checksum="729A399C3AB7A8CE" modified="2024-07-24" version="1">MDQSILRGLNDKIYERRKAAALELEKLVLSSDIPRISSIIDQLCGMFSSSNSALHTRNGGLIGLAATAIALGQDVAPFLGVIIPPVLACFQDPESRVRYHACESLYNIAKVSKGEILIHFNEIFDALSKLSSDSEMSVKNGAELLDRLMKDIVAEAAPHYVSIYPGNYNPNLPPNHRSDNDIYNKLSGLGITNSQQESKEGRLDDSPKLGFSGHGNNNQDKEFSPSRSNDQQAQPPEEDRRAFSLARFIPLLAERIYVISPYTRMHLVSWLMVLDSVPDLELVAWLPEFLDGLLKYLADGNVDVRLATENVLAEFLREIKYIAQVQDKQAEADRLKKETRSVRKRGSRHTLESAIEEDEDAAGDESMTMATQSGYDDQDAEHENDWEGEGSGNWVPGQGVYVDHAAIMDIIIQHLSYPDELVQSTAMEWILTFLEFAQNTVVAFTPRIVPAILPNLASPHRHIKLAAHETNGSLYRVIQSLPLQVQPTPSLSSTTALPPVTGGSVPPPISAIASSPPSGIALSGTSPNPIKKDFATVEPPDSAKSASQVPVNDPLDVTAPSTKQPTPSGITQTLSATNLPSHVQPVVGKSKSLASEPVTPAQAEFPTSSKTKITPSNRPDSPPSHSHTTGSQGPLSPTVEQVEDVDPFDVRETVNVLTLQFLSDHAETRIAALEWLLMLHLKAPNKILSRDSGTFPALLKTLSDPSEDVVKHDLQLLAQISASSEDSYFTSFMVKVLELFSTDRRLLETRGSLIIRQLCLHLNAERIFRTIAEILEKDDDLEFASMMVVKLNMILITSPELADFRRRLKNLESKDGQMLFSSLYRSWCHNAVAAFALCLLAQAYEHASNLLQIFAELELTVPLLVQIDKLVMLIESPVFTNLRLQLLEPEKYPYLPKCLYGLLMILPQSSAFISLRARLSVVHSSGYVPIASSKSSTGSTFSSAAAATKSRLGNKEEIKWQELLSHFRSVQARHEKARRALHSNDLPSLSSTHYSSPSQSGLPAPVPPMISNQGTIKGSSTIKKKSITNSNSINGSRQNSIEVNNRYNNNNMSPLNPKRITSISSTNGPTPSVSIGGAVASMNANTSLGIRASSPTTSRKKILGGLRKSTGGGVVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L7B2</accession>
    <name>A0AAJ8L7B2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Oxidoreductase putative C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_104123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="WWC70175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L7B2"/>
    <dbReference type="GeneID" id="30172670"/>
    <dbReference type="KEGG" id="kpin:30172670"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052515">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013944">
        <property type="entry name" value="OxRdtase_put_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43249:SF1">
        <property type="entry name" value="D-GLUCOSIDE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43249">
        <property type="entry name" value="UDP-N-ACETYL-2-AMINO-2-DEOXY-D-GLUCURONATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase putative C-terminal" evidence="1">
        <location>
            <begin position="160"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC70175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="394" mass="44249" checksum="F09D068A8C001028" modified="2024-07-24" version="1">MSSRFNVLLLGAGPINFGSTEGPWNHSKRLEQKLGERLNVVGLIDLNTERANNVLTIKRADANVKTGYEHTKVFTSIKEAGENLKGIDTPHLAVLGFQANCRGSTKPGHDNELELIQYFPKIGLFIEKPISDVEDFSDVEAVGKKLKENGNVTSVGYMLRYLKAAQEIKRLIDENNLTVMHTQASYLFAYDFAAKDFYGYWSKSREPGPIVTQATHICDLTRFFTPPIILDSVHTNTVEHTDKAGELSIFQFNEKGLVKPEDRIPRVTSATWRYESGATGSLVHAVCLHEGDYDCELLIVADGWKFRLVDPYGISPKLYVRKPGDLEEVRTIFTNDDCYYSEIEAMIDVIDGKSDKSVILSPYEDSIKTYEFTWAIRLAGEKNYNARGGINGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L8B9</accession>
    <name>A0AAJ8L8B9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">I206_105176</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059170.1">
        <property type="nucleotide sequence ID" value="XM_070203069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L8B9"/>
    <dbReference type="GeneID" id="96955754"/>
    <dbReference type="KEGG" id="kpin:96955754"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WWC71223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="104" mass="12233" checksum="CD45AE696A361F34" modified="2024-07-24" version="1">MKFEDKRASYSIGITAGQLLVEQRFGSTVKQLNKALETSENHHKWLNNELHQIFRSRRDHDHKLHEEDYKLEIGLQTYSVLESICDRYPDEQTVASSDIIPIQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L8V1</accession>
    <name>A0AAJ8L8V1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_105175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011809.2">
        <property type="nucleotide sequence ID" value="XM_019155655.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L8V1"/>
    <dbReference type="GeneID" id="30172284"/>
    <dbReference type="KEGG" id="kpin:30172284"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WWC71222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="179" mass="21290" checksum="5935235259CCA86F" modified="2024-07-24" version="1">MARFLTIEELWASWPMEKNPDRELWKYKGEYMLKPRGLPEDARVKDKHVYPSQRTDYDVTDPIRLEWRQERRREKLNVVTVVVVSFAPRDGSYIPWPGLQHDVFSKLWEEAHLDNHESLTVSQKVELAVAMKEEANCTFRRGDWKTAWHEYGRAWMQLLPYHIDAFPAGSEERNSLAEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L9B7</accession>
    <name>A0AAJ8L9B7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytoplasmic protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_105473</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="WWC71515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="kpin:30171992"/>
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        <property type="component" value="Chromosome 7"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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        <property type="entry name" value="Vid27"/>
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        <property type="entry name" value="VID27_C"/>
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        <property type="entry name" value="Vid27_PH"/>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
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        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
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            <begin position="1"/>
            <end position="145"/>
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            <end position="317"/>
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        <location>
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            <end position="721"/>
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            <dbReference type="Pfam" id="PF17747"/>
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    </evidence>
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            <dbReference type="Pfam" id="PF17748"/>
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    </evidence>
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    </evidence>
    <sequence length="742" mass="83847" checksum="A618ACE1FF62DB57" modified="2024-07-24" version="1">MFVLKSLLGKMWGNPANPELMQIPAGQLYLVRPNSIKGSRECIFPDAVATIRRTGVEYQYQLVVTRAYDEGEEQLLDEDAETDDERVFLIDHALGFRFGTLDGDSTCAWRDLSGDDGDLWEFVSSRATNGLFELTLLHCVFERVSHSLSTPVLIMQKHGRSHEDATDTELEALKFNDESVSDQKSVAPATPKKEKTLPEAAVAEDPFKDVPILHRSSAELYLFDLETEVFVIQEKEVYADLASNGEYDTWIIVRHNSTPFISAPIDAEMNPRFDMVNHAFMFTFRETEGLPGMTWCLRFDEKVFEQWKDKFTIFMWEGKNRTSYAKAKADEQRYIQEAYEDVEMAEPDEEDHRAESDEEEEEADRSSADEPDEYQSESEESEADAFERGSKNQQLAVGYKNDVSFVARGDMIGVFAHQDDKLRFRTAIDRVKNLEGKTFSPKKMMLHNQDGDMLLLDPSNQNSVYRMDLEYGKVVDEWKVSDSVEVNNIIPDSKYAQMNPQQTFIGHSHNGLFRIDPRVSGNKLVESQFKQYATKNDFSAATTTESGKLAVASNKGDIRLFDQIGKNAKTALPALGDPIIGVDVSADGRWLVATCKTYLLLIDTLIGDGRYKGSLGFDRSFPADSKPIPRRLQLKPEHVAYMEDPVSFTPARFNTGVNEAEKTIVTSTGKYVIKQYDSRVVADNFKFGADKNIIVALEHNVVMANKRELAKPTRSSLAPRTSLATPVRKIRQSHSDIVNSPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L9Z1</accession>
    <name>A0AAJ8L9Z1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase II subunit A C-terminal domain phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_105789</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This promotes the activity of RNA polymerase II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC71830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_070203192.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="30172978"/>
    <dbReference type="KEGG" id="kpin:30172978"/>
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        <property type="component" value="Chromosome 8"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17729">
        <property type="entry name" value="BRCT_CTDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="BRCT_dom_sf"/>
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    <dbReference type="InterPro" id="IPR039189">
        <property type="entry name" value="Fcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011947">
        <property type="entry name" value="FCP1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
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        <property type="entry name" value="FCP1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081">
        <property type="entry name" value="RNA POLYMERASE II CTD PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081:SF36">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BRCT"/>
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        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00292">
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        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="9">
        <location>
            <begin position="186"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="8">
        <location>
            <begin position="620"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
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            <end position="280"/>
        </location>
    </feature>
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            <begin position="430"/>
            <end position="475"/>
        </location>
    </feature>
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            <begin position="528"/>
            <end position="570"/>
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            <end position="776"/>
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        <location>
            <begin position="790"/>
            <end position="865"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="239"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="538"/>
            <end position="549"/>
        </location>
    </feature>
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        <location>
            <begin position="720"/>
            <end position="750"/>
        </location>
    </feature>
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        <location>
            <begin position="758"/>
            <end position="770"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="800"/>
            <end position="814"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC71830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="935" mass="103728" checksum="685CABE59C73386E" modified="2024-07-24" version="1">MSDPPTPLSLPSTLPYPITITRLLVKPNDTVKRGTNLLEYSFMSKEQKEAISKREKEGRKVNLSKGEIEGDDGSATWDCLIDGEVVNWEGFVKLGTKLERWHMNQPLINIAQPCSHPVQLHGMCGICGADLTEDDYLSAPAPASTSNQAGPSRHPGGFEVTHDSMGVTVSKNEAHRLDNLTRDNLLSSRKLSLIVDLDQTIIHTTVDPTVAEWMDEIDTYNRQESLSPSASGELDNNERSATSSSPRIHETTTPPSSPYSAKKQLPQVTPSPTKLEKNPNAEALSDVARFQIADDLPPGYVKPKRRPGEKMIQMQGRWYFTKPRPGLQKFMDEMSEIYEMHVYTMGTRSYADAICKVIDPDGKIFGGRILSRDESGSFSSKNLKRLFPTDTSMVVVIDDRSDVWADCPNLVKVVPYDFFIGIGDINSSFLPKNKSTPPPSSTATTSISSPAPPSPTSSGSTASTPPPTTPENLPSVEDGLLMKAKLLDDLSESRPLAKMQEEIELNESKTNVLNSYVAKVSNGTISADVKSQETLTEQEPKSRPDEPERMVVPPAVAQPSTPPRPRKPLLNPNDYELLRISDILQEIHHRFYRAFDSLEEWDTKSPLPMSCDVEFIIPELKSKVLEGCNLVFSGLIPQAVNPETTDIWQTAETFGALCSLSVHPRITHCVTATLNTEKTYKAAQIHDAKIVWANWFWDSVALWNRQDEQKYLAKRESRSRTTTPPLPSSEQSVAENHSQKTTNDSISSAELSGFKEDGEIEERENMEDDAEVGKGWDEGADAEWEAFMAEDDDDEDFRTENGSVKSVDSVPSTPSKKRVRYADEESLPLEDFKDPSPTDQDDQPSKRRKPLLLQAPSEQDQIPNENKFLYKGKGKLLSDDRADGVLLNEAMAKEKDVDELSLAGTEATEGTEEDEFAMMLMDSLANEDEGGNDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LA56</accession>
    <name>A0AAJ8LA56_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Proteasome activator subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I206_106969</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BLM10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC73004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059536.1">
        <property type="nucleotide sequence ID" value="XM_070203435.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30173858"/>
    <dbReference type="KEGG" id="kpin:30173858"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016504">
        <property type="term" value="F:peptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032430">
        <property type="entry name" value="Blm10_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055455">
        <property type="entry name" value="HEAT_PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035309">
        <property type="entry name" value="PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021843">
        <property type="entry name" value="PSME4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170:SF3">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23096">
        <property type="entry name" value="HEAT_PSME4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16507">
        <property type="entry name" value="HEAT_PSME4_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11919">
        <property type="entry name" value="PSME4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Proteasome activator Blm10 middle HEAT repeats region" evidence="12">
        <location>
            <begin position="553"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4-like HEAT repeat-like" evidence="13">
        <location>
            <begin position="1535"/>
            <end position="1739"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4 C-terminal" evidence="11">
        <location>
            <begin position="2031"/>
            <end position="2114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="740"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF11919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WWC73004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2114" mass="237985" checksum="21E6BDF40265A4DC" modified="2024-07-24" version="1">MLSGILAINLPFQPTSLPSYGAAAALESGAFSYDDEYYEGEEDIDIEEELAKLEDEYLSAEEEEIDLQMIETWPAATPNRLGEAYIKDGVTKPLQDSDDTRLSYLGLPLCLPYEVETLAEMDDKLELICCRLVECIKAREYGTGFKAWDSALSTWVSMGYPMKRDIKIKLIFVYYELMFIPGLSSSFIEDASNQLISLLNDRSLTIYDFRIPWRPLYDALYTELFPHPNKLARHSVNLAPSFLNVAETAQRFFHPSDVDEMLEEILPKLQLSMDSILATQAFLVHFLPISHCQKWLPIIFRLWHGLNSGFWDDQASDLMGQLAIAHVDPGKSDPSIVNRIPKGTHNTPEEELSNPSVKKRYRLHKIRLLEVAGEVEEDEDGVSFWAKESLLPPDDNLSDPTWAGIRKDVGIFTDQEFEFLMSKCLRSLNVPVGGSIASQNSMSVTLADTRTSKKILDAKKPIDRVQSLAETIIFSMSEDSPFITLPSEAATPGTATPIPGSAHSSTPIQPAISRLQNGSSMARNVSSDSLAVAGQRSERNRRYLAGSKALDHLSKLLTSCETFFHPSNSGHWSVFLTTFLSHLASNFVERWKSEEEPQCRTPASWRLTPAIKREFVLCLRPLALTSMFNKDMNSVTPAVSALKKLALLEPDLIMPAMMERVVPSLQGLEETQRTPAVTYALTALFQPLAARQIWRFGGMYVADIFALLLPGIDLNDPAKTGLSCMAISSMAEVIHMADISDNDQDDSTPGPRAVRSKPRPNVEDDPNDPVQHEMEDLSLGEVNDRVRFATSAFRDWVPEFLGRVLLLFSNLPEEGGKTGRAGGKTEALTLSHVMHACAGVFAALDDKLFDAALDQIIEYATTTCRANAVDAVGELIRHLAFANTAKVFSRLFPICRQRIIHELKTGASSLRTTTTSIPLPADAGLHWWQSILYGTLVPGRVILSDQETRGQYIELLKIMIDSALSERGWQWTGKIVEKSISALTTIFFKDMRFLNDDVYQSEDFKRNHILYWGKLYRSAEVKPRWRVPSEEDIDMALEIIGIADQATGKLNDLLETPSFGDKVWSNEFCRAINVVDKILRGTYNLIAEIESRKTGSVKGGSYLPQEIVTLLPPYKSGLILTNADDPRYQQVAAFRNRVGETLHKAATAMRTAGQSDNSVETVKFLVTTIGTYLTAYGIRSKQFQNNQIAYAGMMSTKKTYESQRKHQRSLLLGVASVAHQHRLAALAHNRVRSELDDRLIVSLLNFCLSPFMRVRRSSQSTLDTVAKLYRGTWVLCFPTLFDALQPGTDPDIMKGALYVLRYNPIGLHRIAQDWRQLLQLTECLLGAHHENKASVQALVGKATDELIQRIKEPVTFNLDLRTEKVHAAVDDLISIIDQKPSEEVVKKVQQGTKDRLKQQDEAWDIFVDRVLAIANAPGLNWRYVLNASRFLLTVMRRDKPTDLRLAKFFMGNVQNPHPRIRDYGTVGVTRMLFHLALRSLCQGSEELLFLEEPIDIFTKDIELTETSPALTQKYLASFKEPLPQDETQALLQDRQDTGWLAWGKKIEVSRLSGWEELGWTCEIPSIEGKNLIEDMLAEKDWWAKLADHWAQENERNYPSATHIDFILALSQTYGPRIYHVIRALVENYLNEMESTKIYDRNKTRAMWEFLAGLARGAAEWGGKDRKEFWDWFGSKLGELYGNIRVDTVKCWDISIEYLLCDQDPRRYKPLVDFCINTALSADFQGGSAFELTRRVQLVRSVIRCLQWRFNAWADDFVELYFKSIDCPYAEVRGSMSSVLNAIDQLKFYPSYPSAALLIADILSDPNDEKDLMRIRSGRFMPQLQSIMNSLPELKKDRPHGPNAVLSTHDASASTALGWLYVELSDVHAVAAFPYIIPILPAIFELRELNDNVDLQRLTGKLLAFIPSITPALDLIEPLMASLISILQDSTSWRTKIHSMPVLSLVYFRNLSLLSEPCKAKCLDVVSACLRDPNQEVREIASSTLSGFLRCSQRSMVVVLKDRFAREIKSTVLPKRRDAPGQINPEYQAKLVQLHGAVLGATALVEAFPYTVPKFMPKLLAEVLAPRVSDPAPISTTIRSCVASFKRTHEKYQDKFSEDELSAMNYAQAGNSYYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LAB3</accession>
    <name>A0AAJ8LAB3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S small subunit ribosomal protein L27e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_106457</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059422.1">
        <property type="nucleotide sequence ID" value="XM_070203321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LAB3"/>
    <dbReference type="GeneID" id="30175630"/>
    <dbReference type="KEGG" id="kpin:30175630"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06090">
        <property type="entry name" value="KOW_RPL27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.770:FF:000001">
        <property type="entry name" value="60S ribosomal protein L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001141">
        <property type="entry name" value="Ribosomal_eL27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041991">
        <property type="entry name" value="Ribosomal_eL27_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038655">
        <property type="entry name" value="Ribosomal_eL27_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10497">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01777">
        <property type="entry name" value="Ribosomal_L27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC72495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="17918" checksum="B959A88E5CA6BBEF" modified="2024-07-24" version="1">MDVDILAKKRYMTIDARFTPITVYKPGKVAVVLSGRQAGKKVVVIKQSDEGTKERPYPHAVVAGIERYPLKVTKNMGKKRIARRSKVKPFIKVINYSHLLPTRYQLELESLKGSVSNETFKEPTQREDAKKAIKKAFEERYAKGNNRWFFSKLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LAC5</accession>
    <name>A0AAJ8LAC5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">lactoylglutathione lyase</fullName>
            <ecNumber evidence="3">4.4.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Aldoketomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ketone-aldehyde mutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Methylglyoxalase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">S-D-lactoylglutathione methylglyoxal lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I206_105961</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glyoxalase I family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.5" evidence="3"/>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059318.1">
        <property type="nucleotide sequence ID" value="XM_070203217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LAC5"/>
    <dbReference type="GeneID" id="30173153"/>
    <dbReference type="KEGG" id="kpin:30173153"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07233">
        <property type="entry name" value="GlxI_Zn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004361">
        <property type="entry name" value="Glyoxalase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00068">
        <property type="entry name" value="glyox_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374:SF30">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE GLYOXALASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00935">
        <property type="entry name" value="GLYOXALASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="VOC" evidence="13">
        <location>
            <begin position="12"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WWC72002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="162" mass="18252" checksum="C30148B0ADDD2972" modified="2024-07-24" version="1">MSSSTTNTATYKFNHTMFRIKDPKVSIPWYENVLGMQKFKESPGGDFTNYFLAFPGGFGDKANASDDEKAAIQLNREGVLELCHNWGTESDPEFKGYASGNDEPGRGFGHIAVTVDNLEAAVKRFDELGVKFKKRPEDGKMRHIAFIYDPDGYWIEILAQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LAV1</accession>
    <name>A0AAJ8LAV1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transformation/transcription domain-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_106535</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. TRA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059440.1">
        <property type="nucleotide sequence ID" value="XM_070203339.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30176292"/>
    <dbReference type="KEGG" id="kpin:30176292"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05163">
        <property type="entry name" value="PIKK_TRRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046807">
        <property type="entry name" value="Tra1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046805">
        <property type="entry name" value="Tra1_ring"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF1">
        <property type="entry name" value="TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20175">
        <property type="entry name" value="Tra1_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20206">
        <property type="entry name" value="Tra1_ring"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAT" evidence="4">
        <location>
            <begin position="2571"/>
            <end position="3134"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="3">
        <location>
            <begin position="3404"/>
            <end position="3726"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="5">
        <location>
            <begin position="3732"/>
            <end position="3764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="235"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="565"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2014"/>
            <end position="2050"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2998"/>
            <end position="3021"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3166"/>
            <end position="3236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="3175"/>
            <end position="3185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="3186"/>
            <end position="3199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="3200"/>
            <end position="3215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC72573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3764" mass="424983" checksum="E8DEA67CA21199AB" modified="2024-07-24" version="1">MSSSGAPGPSTVRANRPRKASTAASHPPGITPSTDNPSQPPAQSQNHTPTPSASAVGGNMSMPPPSFSTNGPLTVADCEFMVSQLLEPSVNPRRKLEIAFELRDSAEQTRDFGFYEKYLAIFIPALITILGDEKSVTFVKDNLEQRYRHTLLAFLQRLPHNEPFRHHMSAVMDLCVKLLKLENEENALLCIKIMIDGLRSNKEQMEPYIEPFLDLVKQMYANTKAVVEKEFGPTGGASASTPATAPTPAAKAPLSAGGNPAAPSPNPATPASDTSAPAQTAPAPQASSSQHHILPHALHSPKVLTECPIAVVLIFQTYKQIMQTAMLDFYPLVIESIKIQPEPQRLAHEEAQKKKEIFVGVANGITNREMYAELIKAQVKTMAFLAYVLRGNQGNNKEYVDVFPEACLRLLRDCPPEDVGTRKELLVATRHILTVESRSCFIPYIDVLLEERVLVGTGVSSRELLRPLAYSVVADLIHHVRNDLPLSQLTQVVYVFSCNLNDSTFNSSIQTMCAKLLNTIIDSIHSKADSEEFARIIKGIFFTFLEKLTAMSEAHDRLKAVGLRDKGKGKAKEETDEDVKMEAEAKETTDDKIQNGWRDIEQAMPVHSVAYANESLESFCRESRYLFKTLLHTFRTLLTYTRQGDNPAPQPDGELLSKFFEHSLKCLAIFDFMGRDPREPKEALELLSQILLLFEPHVFAEVWTSHMPFFSELAITNAQIFPILQMLITHESVSHQLVAILLKHLMNNLEGLGTMDKAQGILTLKMFKISFLAINTYIANNEVVLVPHLQKLIMNSFEYAAKSEDPTLYYQILRALFRSIGGGRFEALYKEVLPILQEMLDNLSYLLQHAADNSQRDLFVELTLTVPVRLTNLLPHLSYLMKPLVHALGAGPDLVSQGLRTLELCIDNLTAEFLDPTMGPVLRTLMAALHKLLKPIPASRNHSNAALKILGKLGGRNRRFQEVDTILEYDLFTDRLIAPITFDGSRHRLQLAPLVITASAVLGEQGQVLSEDGLQVLMYSALTIFQQDAPSPEGNATFQRVMTGLFLACGQPTLGEKALEFVRNLCRRAFALELGRTESTDPNAKSYPDHSKKRFLPLTNALSDCFVATLHDSKPSERPGLSDLLATIVTDFKELAHSSTFAGKVDGSRSFERMVAFLAHRLVSLCHEEDWSKKMAGMTAMSAFVHKIDLSRKMMIDFELDFVRALLFCLRDAPKDTPKTSEEVIDLIKHLLKTCQSQEDGKPRLPRLAETLVAELNSQSPLARRASQECIETLAEITNQSVPELITAIAKAKLLNTEHGPIYSKPLRALPFAMQVANINAVTYLMDLRPSVPDTSEEFTRLLHETLALADVDDANLISKPATHKSEIWLKKLRISCLKLLKSAMSAPDFLNKPNLAQLRARIIQVYFKHVYSSNPDIVDVAHDGLRDVLQQQNKLPKDVLQQGLRPILVNLADAKRLSVSGLDGLARFLELLTNYFKVEIGTKLLDHFKTLGDENMLKQAAFSPLDDNPDIARMARLVNIFRLLPSNAITYLNDLVAEVVKVEAILHQSVPGPFTENLGKYLNRYYQNGAQNLIDHVKDPRYIWTYRNIIASGCAPKLVEELATKSEILCQLCFGEPEDNDTVLPGLYLIRELSRVSATWLMDDNSAGEPALEPLVKVWRIIVSKSRDHKSDMTSYHYQQIPSLLLEMFMTSLRNQRHVALLFHVVEAYEVRASFERSNVSFFLYQQVALVDDLQYRKEVIEHFFELYEQESVSWAFKTNALRVIINPTLRVHFSQPDADQNIISPQLVQKIANQMWRPLAATAAAKQREDTHLIEVFALTTLLVQHCSAKVNEARKEIFKLAWMGINLLEPTVKLMAYVLAARFMATYETPVKFVRLTWTGVLRLKETDNRTLYRQAIDTLASSLSVRDPPPASGTPEWAKLLRTVLIEEGHATNQLVTVCELLVNHPDLFYDYRELYVPHVANSLSKLAFVQAATPELKKLTVDIVELIFNWEKRRMAARDADNMSMDIDGSGSKRTGDHFNEQSPVKRQRVDRAGTAISGSSGGGWAAPGQVRELMTAHLLRLVSTSTESVTRNGLTRRALDLFKEILGPKGLPNVHVKLGFFQRTMTQDINDNTRTTVANSTEVIAAAAAVRDRHWVKANLGLLSKLLEKVWVSDETELHEVVAPLTEDLFAEMPSDETAESDPEPKALFTFVQNAVNDGLTSSLRSSSNLPGTLFLLRSWLKTHPKVLQSEIVSSALLKVLGNLVKVHTGNTNPPPQGNDPDFTAKLIISVLDIVRDRVSDLREQRKHLYSIITTLVDRSLSPALCRYVLKLVRHWVIEESDGAAHGKEKAGILLKMPGFEQREDDLFQEYLDVIYEIYEDDKLRCTDITHRLEPAFLLGTKSKNAIQRAKFLDKLEQSLPRSLDGRLQFLYSLQNWDTLADCYWIPQILSQVLGIVDHEQKLVRKPSTTLLETDPIMDMALQATVSDIVTPARNLIHVDNQLANKLWIEIFPMCWSSLSRAQQTAFTPYIVKLLAKDYLRKQVEMRPNVVQTFLDGILACRPPITLPPLLVKYLAKTYNAWYVGFEILTKLTDVYRADEGLRESCASALSELYAELCEDDMFYGLARSRCVFPETTAALTYEQNGLWPKAIELYEQGQIKARNHLLPFTQEEYCLWQDHWILSAQKLQNWENLTELARVDQDADLLLECAWRLSDWTSPDRDMIEQNIARISDIPTPRRKTFEAFTSLLRSHLAREPPNEFLKVLDEAQQVTLRKWVSLPTNITNAHLPLLQMFQQCVELNEAAQVFDSLQMTNQQNLEMRCNSDLKTIFTTWRDRLPNFWDDISVWSDLLAWRQHVFQAVTRVYHPLIPPGDTATYGYRGFHETAWMINRFGEVARRHGLLDVCSVSLNKIYMLPNIEISEAFLKLREQALCFFQKPDKFNDGLDNISTTNLMYFAPPQKAEFLTLKGMFISRLGQNEEANAEFAHAIQMDMNLPKAWAEWGRFNDKLYRDRPENVPGPQPEPEPGKPKMTEEQWQDSYTNDRAILASSAVSCYLQAAGLYSNHKSRGLLLRVLWLLGLDDSRNTISKAFENYKGDLVIWYWITLIPQLLMSLSHREAKQARLLLLRIAKQHPQALFFHLRVSREDFVGVKKQQMQSRAAAQRRAEAQAKAAAANAAAAAEAAGENKPAEDSKEGVKSEQQQQNGDSNTPTANGDQQNGQQPDGAPNVNGQMAPPAQVPPPPRQPWDHVDEIMNMLKTAFPLLALTMEKMVDQISLRAKPNSDEDIYRFFSALLADAMQQWGGRGGLPNDDGELSAQTKDNLAKFATNLNGDLKASIEKDFMKDMPKLREYIKRLQRWRDFYEKNLDARPKVQPLDQGGCNLTEFHHTKFDDVEIPGQYVHHVDQGEEFIKIARFAPKAELGRGHGHCFRRITMIGNNGSSYTFHVQMPAARHCRREERLTQLFRIMNSVLKKRKESRRRNLQFHLPTATPLAPQLRLVQADSSYVSLQDIFEDFSASKGMSREDTTLAYFDRIKQLHDPAVPRTDPRFSQLKAEVMEEIQTKMVPENIMTNYMIRTMDSPESLWLMRKQFALQTATTMFLTYVCCLSNRTPSRFYISRKTGLMYMTEILPAFAPGQPLIASQEQVPFRLTPNMQNFITRIGIEGVVTAACTAIARCLTQPEFDLSGTLCLFVRDELLIWHNTYMKDARQDSPLINHVYKNVDNFIRRAGTMGYIGENKDKAPGASPVAHAIVTLISQATAPLNLAQMSETYMAWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LAX7</accession>
    <name>A0AAJ8LAX7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_106294</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059389.1">
        <property type="nucleotide sequence ID" value="XM_070203288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LAX7"/>
    <dbReference type="GeneID" id="30173490"/>
    <dbReference type="KEGG" id="kpin:30173490"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF21">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="2">
        <location>
            <begin position="56"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC72332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="371" mass="41713" checksum="511519F8F9A65A7C" modified="2024-07-24" version="1">MTLITGSALQVSPLPLKGSRQWKGHQFPIAFRVDQAGKTPDIEQSVSYLHGLAASGEFTHLLQQHGGVVFRGFGSPSAETFSKLVNAAERGRNNTPYEQVGLAGKRTAQASEVYTANEGPETQRFFLHNEYARYTRYPGFIHFYCEVEPITGGESPIGNSLEMFDRIVQEIPEFVKEVNERGLSMTQIYPAPYDNDGKSNYFDYTGVDTFGQTLKLGDDQETIRQKVEAQVRRLTDDYEWLEDGSIRVVQHVKAANLYLGLPNWFNGLSARHGTATFMDALEPPYKGTDGKTYPPATYTDGTEIPRAYLDRILAISRELEIPFKWEAGDILFVDNLRTMHGRAPWSDGPRRILVSMWDVLPGTVDNYRPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LC36</accession>
    <name>A0AAJ8LC36_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Vacuolar protein sorting-associated protein VTA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_107071</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VTA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC73106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009824.2">
        <property type="nucleotide sequence ID" value="XM_019157106.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LC36"/>
    <dbReference type="GeneID" id="30173754"/>
    <dbReference type="KEGG" id="kpin:30173754"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.270">
        <property type="entry name" value="Vacuolar protein sorting-associated protein vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044538">
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    </dbReference>
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        <property type="entry name" value="Vta1/CALS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023175">
        <property type="entry name" value="Vta1/CALS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041212">
        <property type="entry name" value="Vta1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04652">
        <property type="entry name" value="Vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Vta1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vta1/callose synthase N-terminal" evidence="10">
        <location>
            <begin position="19"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Vta1 C-terminal" evidence="11">
        <location>
            <begin position="473"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="160"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
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            <begin position="243"/>
            <end position="267"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="9">
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            <begin position="321"/>
            <end position="330"/>
        </location>
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            <begin position="348"/>
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        </location>
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        <location>
            <begin position="445"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007895"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC73106.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="509" mass="54342" checksum="E71738F0F0699512" modified="2024-07-24" version="1">MDQVKIPTENVPPGLKQCEQILKRANEIKKAEPVVAYWCCFSAAQKALNLKQRTKDDTLFLMSIIDALESMKVILANNEAITSEAAGAALVENFALKVFLSADNDDRAGNTGKASIRKFVVAGQFIEVMKCFEGGMTDELEQKLQYARWKAADGAKALREGRTPAAGPPIPETQEEFNPFPTIPTDAPSDPSHQHESPSQSRGSFSSQTRPQIPSNSSNTSTPIISPRPSPAPASRPTLPELKTSQGDLRTPTRNHSTGSGAWSTVATPGLPDDDSEMHVPPNKPELILPSAPPMTPPEKGSPGDKKNVRFMGPDGAPLSPASTHFTVSSYDVPPAPPPTDFASEPASPKPSPPTVVLQPPPGRPRGDSSASTSSRSGGNGINNHQPVNGKSPSSNTPISRNGQANTQPKQATNSVTVPPPPPPSLASYPMHPPSQPRPHGLGLTSPQPAQSQPHQHTSQSYGPTRTGLSRREVETVQKHAKWAVSAMEFDDYETARSELRKALNMLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LE97</accession>
    <name>A0AAJ8LE97_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_107857</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="kpin:30174557"/>
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        <property type="component" value="Chromosome 11"/>
    </dbReference>
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        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
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            <begin position="1"/>
            <end position="16"/>
        </location>
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            <begin position="17"/>
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        </location>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="577" mass="65512" checksum="042483C50087F0A3" modified="2024-07-24" version="1">MLRKLLLTGFVAIALAEQVPFNVDSPDDSGHYEFEWPIKDVAIIGAGVSGLLSYRALSNTEDFTKIKIFERDDSPGGNWHYSDEIPKSIPIELGQTEYWWKGDFIPNIPNNIPSHKVYKVESNQTFENELENQRILHRQPKPLWKTLRANTPAPQQQVPGFEWPKGVEWASHHSKVQRYLRSFASWLGINNGDEKTNVSYNTRVELVEKNLNKIGKQIGWTLTLRKFLRAKEGCYEETYWKENFDAVIVAAGRFNIPHIPAIEGLVEWSHRFPEQVFHSRQYRYGESAVGKNVIVIGASASATGVSQDINTYAKNSYLSIREHSDDPRAPVRRDTHLNALPRNTTIIGEIKRFHPISDGGGISEGKIELLNGTIITGINLLIFGTGFRYSFPFLPQYHNSSILGNETAESEEQPIVTDGSHVRSLYLDTFYIDQPTLAFQGQNVGIQTFVYGKYAGEAIARVWSGKAHLPSKKGQWSHFWRTVEERGGLRKGFQWLNNESNSRYLNFFVAWLNAAAIKNGGRLLELPPDVSEEMDLWMKARAAGVFINPDGRNDFQSASEKGVLDNIQWKKAILDDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MK87</accession>
    <name>A0AAJ8MK87_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_100444</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058304.1">
        <property type="nucleotide sequence ID" value="XM_070202203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MK87"/>
    <dbReference type="GeneID" id="30169254"/>
    <dbReference type="KEGG" id="kpin:30169254"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="3">
        <location>
            <begin position="174"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="399"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="509"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="408"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC66541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="631" mass="71792" checksum="9E5D18633712EB80" modified="2024-07-24" version="1">MVKARKSSQCNISGQPGPSSTGSRGSSSATTYTTIDIEENEPHNQTKVSTLYQFLTYIFVANMVNEQLTSDEKKALSVLHQLCAFEQIFMEFFSKLDGLDIVPVRGSLVLSYDRSELFINPENGRAARRTDDATALERIIKDITQSQLDAKDNVVPRSYLLRIQDNFLAALRNPNLRLGESDIMKGQIGLFVKPKENLSRIEVLQKRNRPLNLEGIRFQLFSFPEKVTRPQDHGFLDDLSFDYKHRRVGEYNSKNYVLIGLGVARVINHHCTRSNVEWPFAPNALKFKDGHKEIGVMTSGLLLKERRSLEAGSEILAYYGDEFARLDCPAYHGSHNHRKFATFAKPTPPPIYNRQDPYANLDSASRADSIDLDGIQMEGPSSTNRKPIDALQEFFLDLENDEKDNTPKRSKRKKRKSRDNKSNYIVQDRDDDNEVEYLETRPLTETRRASPKRKRRVKSDDIVEDTEEEEIQDVISLNGSTRANPTQDEDILIPDSSIPVEQSRHRNKNAQIIDRVNELDEEIEKQLDALRDREKQFDKLIEHLIDLKEGVKRDGTVLRELRQKNRKLVNEIRRDEKGKARESVAAIQGDLKGIQTSSSAQAMMKGSNSTCSSVSCSFFSTTLASFANANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MM29</accession>
    <name>A0AAJ8MM29_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleolar protein 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 4">Pumilio domain-containing protein NOP9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_100224</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058257.1">
        <property type="nucleotide sequence ID" value="XM_070202156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MM29"/>
    <dbReference type="GeneID" id="30169470"/>
    <dbReference type="KEGG" id="kpin:30169470"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040000">
        <property type="entry name" value="NOP9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22493">
        <property type="entry name" value="PUF_NOP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="276"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="547"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="743"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="547"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="573"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC66323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="789" mass="88594" checksum="C475B0B60C349E2F" modified="2024-07-24" version="1">MPKEQVRKRGRRVRKGDVQVEDEDIQVLPTTEINEPIPSASTSTGIHPARAAFLAGRPAPPSQTQTQSQDTEGIQRAEDEGPAEWNRGPRIDSEFPFGVLDPDVKAYFRNVEEQIKDWEGVSSEGEEREDRQLFLTSVLSELRSHELPTSTDPETSIVLERLLPSLNDWGRRVIGDSFGDKWEELIRHRFGSHVVQTWLTLAAGTLDREAREIWPPQQSKQTDSNEGQLPKMTELLINIINALSSSFAELSSSPHASPPLRLLLLILTPNRSLPALESNQGDKNGLIRSKRSNKFRKNQDVKGKSILGDDAESSQHKKRKVPSDLILKRKEITDSLKARLGEAEWKAMGVDTVGSATVQLLLEFEVEDGEAEKEGSLFDILTEGLVTQLSKDPKAIPEPQPYLSTVLQTQTGTRLFETLLSLAPERVFKALWRTYFVGKLGKLAGHPYANFVSAKGVSRLDKKGIESLISEVKGNSGGRGLIKAARTSVIQALVERAATLGECQQDVLKLLYSCLELPEEKKSEFVPCLMALKTYPMYQAILAGSDAPEDTEEPLEEADKEAEDTAAAYARKSAWENRRTAKPKAGEGEVLPNMQGCLILQGMMSMGDVNGVVIDSLTAQPVDTLLTYAKSPISSHLLDKVFNDPAVQPKYRRKVMMILMNDWKEIIEDRIGSRVMDVVWDKADGYMKEKIARTLIPHIIVLGQSQYAKYFLKKAELSLLQRRPDEWREKIVGLKHHFAHQKKISQQSPKFNENGIENENIKKRKNENKDEIDILFENVDKQKSKKRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MM81</accession>
    <name>A0AAJ8MM81_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_100390</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058285.1">
        <property type="nucleotide sequence ID" value="XM_070202184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MM81"/>
    <dbReference type="GeneID" id="30169303"/>
    <dbReference type="KEGG" id="kpin:30169303"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF1">
        <property type="entry name" value="PYRIMIDINE PATHWAY REGULATORY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="9">
        <location>
            <begin position="177"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="98"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC66488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="534" mass="59562" checksum="E5A9DE3BB401332C" modified="2024-07-24" version="1">MTSPAHNGAASTSTDRESNGDTPARPAIASTGIGRITPRSACEPCRTRKIKVSTLQSNEADNRSVPEKDRHALGVKSKGKNVYMRMRQLPGEGERAQWIGQQDPEHSNKRQRLDGSTPPELPPSPSLQRRFSSGGGSGTVHPPERQAMINELPSVHPVLIPFDRSALPPPQHIHELLSHFFLYTNAAFPLFHIPTLQRQVDVVCFSDDLVNRSDLAAVLFALAIGAASLFRTSPLHSLLSPRAESFFHMAMRFTMHGVGFNSLARLQIQVAHLIFVLYNPNAGNAWDLAGAAARHALGMGLHHEWDDQVKTPLEREMGRRLFWIFHPFTMTPSLPTPPYTQSPPATSWFETMTERLDQWLVICPEGAGYANSDWQTLHYHASISMLHRPSRANPTPDREAVTKALISSREVLRRSKDMYRMGRVNFRVTYLNCLWQSRQNGWNIVPSSVDAFLDVHVCSSLMEGVAAITPGTSGIRNAFEAVSEKVIRQVMSSNERQTSPIHNNPLEVFLVHPLGDMNGDEWDRTVAVVLQRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MMG2</accession>
    <name>A0AAJ8MMG2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphoglycerate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_100389</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058284.1">
        <property type="nucleotide sequence ID" value="XM_070202183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MMG2"/>
    <dbReference type="GeneID" id="30169304"/>
    <dbReference type="KEGG" id="kpin:30169304"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050418">
        <property type="entry name" value="D-iso_2-hydroxyacid_DH_PdxB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43761:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43761">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G13630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="10"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="177"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC66487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="32947" checksum="D8FA4EB1A8BFDE4F" modified="2024-07-24" version="1">MPSSTKPIVVALNPLHPQALALASEHFDLILPDSDRFEAWREQAQGMLTISAKVTREDVEESTQYGQLKYVAKQGTGVDMLDLAALREAGIVVMNTPGINVSSAKANRADSQAQAVAELALGLIIDSTHARFYAGESISKADGWEGQTLFGKTLGLIGDADLQKWGRGIPTTDFTHTSSFEKLLKESDIVSLHCPLTKDTKDMISAEQFDIMKRSSILVNVARGGIVNETDLEVALREGKISGAGVDVTVVEPPTTEKYGSLCRAGCIITPHYGAAPAEVQEATCLAMVQHMIDALEEGNIRNRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HSI7</accession>
    <name>A0A1B9HSI7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_07711</name>
        <name evidence="3" type="ORF">I206_103762</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700118">
        <property type="protein sequence ID" value="OCF46234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC69819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007453.1">
        <property type="nucleotide sequence ID" value="XM_019159401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HSI7"/>
    <dbReference type="GeneID" id="30176080"/>
    <dbReference type="KEGG" id="kpin:30176080"/>
    <dbReference type="OrthoDB" id="2564873at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="663"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="714"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="663"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF46234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC69819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="793" mass="86604" checksum="4C15D406E7989BA1" modified="2016-11-02" version="1">MSSPEEGIIPCRNRLTIPKFTSKIQPPSTLPLRTTSKIRQPQTTGRPSTVHHLQVAGSLNSESKIPPPRVSFLTPREIWSPLATPIPGMQQIKQDIRAGAAPARVPKYQLKDPGPIPQSASRSHLSTTPKPQIRPRLVSRPSIKAHRQASVQRPPAHIPRPPIRPSQQFTPTQQASRLPLPSSTNRARPLSLPPDEASSVIIPHTRPTSYQPSPSFPLSASPSYLSKAVGIPEPRPLLSQPIHDQLDCRVPGSIAPSRETSNQSTGSSVYSSASSLARHRAIKGRGKDRSSFARLSAYSPPNHDCLVKALCAESESEDTESTLSDHSIRTVATVNQVVNVENIPIRHLSLSASINSPERSLKEEPVSEESFMLSSEDHRGLTAPYLVPSSAPPMTLEWESDESSGEVDEAERVWKELEAKLGRKVRGRSLRRGKWVVKPREHPVVELTPSLDTRNMKEEGVDMEKTASGFSLSMYFSPQSSRSTPPLDIDRCRSSSFTYDSSPIVASPSSATALFDMSAPLVPGGIDNGCTPWNTPLVNTESIKRGTRVKKRFASMDVAEIGQKNRLGSLEEVAKIDFTPQQSQSREISSRCLLERGLTTTNPDQEDSPDDCQTLSPPIGLSDLHGTQTDHNTAPRMMYRLDSHIVSALSALQGSYDSPDLDFALSSSPPLSPASDVATEEDFEGSTGNGLGLGMNLRLRTIYHLPTLSPRLRPSAVRTATKTASRIESSNGNSMAIDPTQRVDETMDYTLKSDSSSQIPEVNEEDDEEVLVIRDLDTGLERQVKVGDGLTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HTR6</accession>
    <name>A0A1B9HTR6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_07508</name>
        <name evidence="3" type="ORF">I206_106601</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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    </evidence>
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    <sequence length="332" mass="37840" checksum="A822D30B1370D2C3" modified="2016-11-02" version="1">MQGRSIASGPSTEYHPPIQTSIPLSSINTLIPRLTTTINDIDNLRNLIGSGYTEGTLPSWDNLLQRYSLLLGRINSLTNYLIPSSSSTNIKGNNKSLSEYLIHPLNSISINSEEEISSPFLNETFLQVINTQLLSTTTTTTSSFQTNSIIKKSDSESNSHSHYENNNNNTYHNLEELKKLNEFELENLKKQLNLRLNKENNKILNIKREIEKQKEEIDWTMRIGEEEEDDDEEDDQHLLENANGKQKEKEKDNDAADDDVDDDDDDLFGGDEEEEEDEPMIIDVDAEKLLPMVNNDQQQDKNSSSHSQKDWKLEDYIIFMDSGKLPIPTSNS</sequence>
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    <name>A0A1B9HU03_9TREE</name>
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        </recommendedName>
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    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="6">CBS 10737</strain>
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    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="5">CBS 10737</strain>
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    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL34 family.</text>
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        <property type="term" value="C:ribonucleoprotein complex"/>
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        <property type="evidence" value="ECO:0007669"/>
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<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">CBS 10737</strain>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894015">
        <property type="protein sequence ID" value="OCF46854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008073.1">
        <property type="nucleotide sequence ID" value="XM_019158935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HUB1"/>
    <dbReference type="STRING" id="1296096.A0A1B9HUB1"/>
    <dbReference type="GeneID" id="30175610"/>
    <dbReference type="KEGG" id="kpin:30175610"/>
    <dbReference type="OrthoDB" id="2537769at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012808">
        <property type="entry name" value="CHP02453"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02453">
        <property type="entry name" value="TIGR02453 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36452">
        <property type="entry name" value="CHROMOSOME 12, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36452:SF1">
        <property type="entry name" value="DUF2461 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09365">
        <property type="entry name" value="DUF2461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF46854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC72475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="54226" checksum="E5808B1D4A31DDB7" modified="2016-11-02" version="1">MVKAKTTPTQPKARASPRISAASAKSTPTRSSKQASTSTPLKSSISSTPTKGKWIEKSAKTSPYFPKSKTTSKPAQKSKGKAKILAKDEDEEREHSPSGLTESEQSSTDDEGSEDDFIAFGESELDEPIEEDSDEDGSVDSDFIDEGNSKKRKSTSNSRNKSSVKKAKITKLTNGKQSTTRIEGYEDEDEDDDEEIELEEGQEIAGRIYPAPKSGQVPPGMISQNTLNFLKNLQIPERNDREWFRSHEPAFRQAENEWKAFVGIVQMKFHEADDEIPILPSKDIIHRIYRDVRFSSDKTPYKRNFSMSTSRGGRKGIWAAYHLSISPNNKSLLACGIWQPFKNELSLIRQNLLKNPKKFRKCISDIEFIKLFGEPKEDKKTGKRQNVFGNDDALKVAPKGIEKDHKDIDLLKLRSIAVVHYFKDEQVIAKDFQEQLYDVLVVMRPFVRLLNEYVTLPPDNDNNEEDADEDEHEDQGEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HUF6</accession>
    <name>A0A1B9HUF6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase</fullName>
            <ecNumber evidence="4">1.1.1.302</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I206_07293</name>
        <name evidence="15" type="ORF">I206_106488</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27274"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27278"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HTP reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.302" evidence="4"/>
    <dbReference type="EMBL" id="KI894015">
        <property type="protein sequence ID" value="OCF46906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008125.1">
        <property type="nucleotide sequence ID" value="XM_019158987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HUF6"/>
    <dbReference type="STRING" id="1296096.A0A1B9HUF6"/>
    <dbReference type="GeneID" id="30175662"/>
    <dbReference type="KEGG" id="kpin:30175662"/>
    <dbReference type="OrthoDB" id="5432at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050765">
        <property type="entry name" value="Riboflavin_Biosynth_HTPR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011:SF7">
        <property type="entry name" value="2,5-DIAMINO-6-RIBOSYLAMINO-4(3H)-PYRIMIDINONE 5'-PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_8G06820)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="Bacterial bifunctional deaminase-reductase C-terminal" evidence="13">
        <location>
            <begin position="22"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCF46906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WWC72526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="255" mass="28070" checksum="B258C8A6AEA23D7D" modified="2016-11-02" version="1">MTGVPQFLIDHLPTASATVERPHITLTWAQSLDSKIAGPGGSRVILSGPESMLMTHWMRSMHDSILIGVNTLILDNPRLQANLLPPSLNLPPPQPLILDPKLRFPINSRILNEWNTKPDQRGKTLRQPWIICGDNVSSNRISEVENAGARVIPVKLDKYGYISPSSLPSILYNLKLKSVMIEGGSKVLSTFLHTQSRDDGSKLIDSMIVTVAPMFIGEGIGFIPQNEDIGLPKLKTVHTEIMGKDAVMICQVDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HUX6</accession>
    <name>A0A1B9HUX6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA N(3)-methylcytidine methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_06849</name>
        <name evidence="8" type="ORF">I206_102058</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the methyltransferase superfamily. METL family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="KV700117">
        <property type="protein sequence ID" value="OCF47075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC68135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008294.1">
        <property type="nucleotide sequence ID" value="XM_019158548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HUX6"/>
    <dbReference type="STRING" id="1296096.A0A1B9HUX6"/>
    <dbReference type="GeneID" id="30175218"/>
    <dbReference type="KEGG" id="kpin:30175218"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052735">
        <property type="term" value="F:tRNA (cytidine-3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026113">
        <property type="entry name" value="METTL2/6/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809:SF11">
        <property type="entry name" value="TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037755">
        <property type="entry name" value="Mettl2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 12" evidence="6">
        <location>
            <begin position="144"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCF47075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC68135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="367" mass="41929" checksum="77919CBF2DB9D0F5" modified="2016-11-02" version="1">MADLPPQPEASTSKSPSIIAPEPVSATKMRVADKWVKPNGPPVGSTFGARLLDDEKDVFEHNAWDHVTLPEDFKIKAQEIMELHRNSPVAEALRDGYNSKPAHYWDKFYSLHEEGFFKDRQWLRLEFPELVACSEADAGPKIVLEVGCGAGNTVFPLLMRNENPDLHIFATDYSKKAVEVVKANKMYPKAEHGLGELHSSVWDITSKSSSNRNLKENLENLKLESNYSLPEGIEPGTVDVISVIFVLSALHPKEWEQAIRNLYNVLKPGGLLLIRDYGRHDLAQLRIKKDKLLDPEIPNLYIRGDGTRVYFFEKEELENMLVAPLADEEEKKMFEVLQLGEDRRLLVNRKEKKQMYRIWLQVKAKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HVK8</accession>
    <name>A0A1B9HVK8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">26S proteasome regulatory subunit RPN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_07086</name>
        <name evidence="9" type="ORF">I206_101824</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the proteasome subunit S2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700117">
        <property type="protein sequence ID" value="OCF47307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008526.1">
        <property type="nucleotide sequence ID" value="XM_019158780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HVK8"/>
    <dbReference type="STRING" id="1296096.A0A1B9HVK8"/>
    <dbReference type="GeneID" id="30175455"/>
    <dbReference type="KEGG" id="kpin:30175455"/>
    <dbReference type="OrthoDB" id="10252509at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016643">
        <property type="entry name" value="26S_Psome_Rpn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041433">
        <property type="entry name" value="RPN1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040892">
        <property type="entry name" value="RPN1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18051">
        <property type="entry name" value="RPN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17781">
        <property type="entry name" value="RPN1_RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015965">
        <property type="entry name" value="26S_Psome_Rpn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RPN1 N-terminal" evidence="6">
        <location>
            <begin position="59"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit RPN1 C-terminal" evidence="7">
        <location>
            <begin position="935"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="651"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="663"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR015965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF47307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC67906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="993" mass="108732" checksum="9E75D4E3ED7FF543" modified="2016-11-02" version="1">MSDSDRPTFDIAVPSKDPEKKDEDKPKSNGDLKGKGKDESKEEDINDMSEEDLQLKAELEMLVQRLKESDINLYLPALESLRTLIRTSTSSMTSVPKPLKFLRPFYEELGQIRDSWDAELKEQRSLLASILSVLAMTYSDTGKRETLFFRLLSESTEAPGLWGHEYVRHLAAELGEEYNSNYAAEIDQDIEKPEGLKYTTEQLKALALELVSFFLKHNAEADAVDILLELENVHEIVELTDDKNFERVCRYMVSCVPLLVPPDDSAFLETASKIYAKYDRYPEAIALAVRLNSPALIRQYFQAPKNPVMKKQLAYFLARAQIPLHWVHTAEGAESDEEEPAATQEEDVLECLGNVKLSTHFRNFGKAVGVEEPRALEDIYKSHLEPNRTTQTADSARQNLASTFVNAFVNAGFGNEKLMVNAAEGQSWIYKNKDHGIMSATASVGLSLLWDTESGIDHIDKYTYSPEEHIKAGALLAIGVFHSGIRTETDIAYALLEEHVDSKSLSLKLSAINGLGIAYAGSGRKDIAEKLLPHVADETNTMEVAAMAALSLGFVFVGSGDGEIASAILQTMMEREEAQLASEWTVFICLGLGLIFLATQEDSEPTVATLKVIEHPIASIAETIVDVCAYAGTGNVLKIQQMLHLCAEHAEKPKKDTPNGETAPVAAEGEGPAAAAVADAEGDVNMSGENTAQPITAPVGEATATSTAAPTGDSEGEDAEEKEKVDSLKYQAFATIGIALIAMGEDVGAEMALRQFQHLMTYGDPVIRKSVPLALGLISASNPQLSILDTLSKYSHDSDLDVAINAIFAMGLVGAGTNNARLAQMLRGLATYYAKEPDCFFMVRIAQGLVHMGKGTIGINPYFSDGQVMSRTAVAGLLATIVSFTDARKFVLDKHHWQLYWLVTAMYPQFLITLDEELEEKPVTVRVGQAVNTIGLAGTRHGISGFQTHQSPVRIATGERAELGTNEFFPYQSVLEGLVILKKNEQYNAEDQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HWT3</accession>
    <name>A0A1B9HWT3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit F</fullName>
            <shortName evidence="4">eIF3f</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_06642</name>
        <name evidence="8" type="ORF">I206_101388</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit F family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008955.1">
        <property type="nucleotide sequence ID" value="XM_019158342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HWT3"/>
    <dbReference type="STRING" id="1296096.A0A1B9HWT3"/>
    <dbReference type="GeneID" id="30175011"/>
    <dbReference type="KEGG" id="kpin:30175011"/>
    <dbReference type="OrthoDB" id="25498at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08064">
        <property type="entry name" value="MPN_eIF3f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03005">
        <property type="entry name" value="eIF3f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027531">
        <property type="entry name" value="eIF3f"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF6">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="28"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCF47736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC67480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="304" mass="32373" checksum="5FD8C05626322F09" modified="2016-11-02" version="1">MSLDTSSSAIHLNLPPTSSTQIRPPTLITVHPSVVASILTHHSRKSTEADSSNRVIGTLMGSRSENGQEIDIRSSFAVPHKEDENQIAVDMPFQQGMMQLLGKTGAKESIVGWYATHPTLNAYSALIQNYFTGETSPHPSVHLTIDTELDPSGKGLGIKGWVSTQLGLSPKPENCAFLPVPVVIKYADSERAALDLLTAPAPTPSPSLPPLPTLSASLTQLSTLIDQALTYVQSVNSGSQNPDAEVGRYLLEGLGRWSGSDNEDEGGVKAGLQDTLTVSYLSNLVRSQVELAGRLALLQQTPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HWW7</accession>
    <name>A0A1B9HWW7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CCAAT-binding factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_06663</name>
        <name evidence="9" type="ORF">I206_101368</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008975.1">
        <property type="nucleotide sequence ID" value="XM_019158362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HWW7"/>
    <dbReference type="STRING" id="1296096.A0A1B9HWW7"/>
    <dbReference type="GeneID" id="30175032"/>
    <dbReference type="KEGG" id="kpin:30175032"/>
    <dbReference type="OrthoDB" id="10263185at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027193">
        <property type="entry name" value="Noc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455:SF0">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="CCAAT-binding factor" evidence="7">
        <location>
            <begin position="425"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF47756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC67460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="677" mass="77115" checksum="0331A25B0A789EAB" modified="2016-11-02" version="1">MVSSLSKSKKATSSSSKVKVNPNPSSSTANPLNQISKLESTLLGDEYDPNPLLPLISLSRHEDPQIVHKAVWALHRVFIKFISEGKVGGLNGDLIIKRKINEDKGDNDFGEEREVKAWVRERLLEYIEVLGGLVRDKEPALRSSSIPLLFSLLPPLSTSIQSSTPLIHIPYFRLILDLLFNPKSSLRGAKPKSSGGWKIVEANQVEEDEGILPVDVAQIVVDDFWAKHDDIRWAFFKESSNFIQNIDGEQSISNHSNLLAQLGPLVNLPKTPEDINTFYISTFTEPPTTKSLNKKLKKNNKKGKLRYKGEIDELPSWMKEYESENSDSEEEQEQEGKKGTKRIREKVSTLSIHQSVYSLQSHKTQYTNLWENVLSYLKLDDFWIRKILIGLHGEYGILGHFKPERRLRIADWLSTLVDNGGANAMLGMNGLFVLMTEYNFEYPHFYDRLYALLDRNVMHVKYRARFFRLLDTFLASSLLSSALIASFIKRLARLTLSSSPAGIIIILPFIYNLLKRHPGTMILIQRPDDDNNNLNILKISSTLGKQGYIDPFNNEEKNILKTNAINSSLWEIKSLQKHYLSSISILSKVFNEIFTKPQYNLEDFLDHGYGTLFDTESNRKIKNPPALSILIETSTPEILTDLFPTSDFIKDLKNQEEEEGQEIIAKQGDIISELWTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HX71</accession>
    <name>A0A1B9HX71_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cardiolipin-specific phospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_05727</name>
        <name evidence="5" type="ORF">I206_107401</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI894014">
        <property type="protein sequence ID" value="OCF47866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009085.1">
        <property type="nucleotide sequence ID" value="XM_019157445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HX71"/>
    <dbReference type="STRING" id="1296096.A0A1B9HX71"/>
    <dbReference type="GeneID" id="30174096"/>
    <dbReference type="KEGG" id="kpin:30174096"/>
    <dbReference type="OrthoDB" id="7457040at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042171">
        <property type="term" value="F:lysophosphatidic acid acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886:SF29">
        <property type="entry name" value="PUMMELIG, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886">
        <property type="entry name" value="RE40534P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="213"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="358"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF47866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC73433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="566" mass="62958" checksum="73C71FBA9C84E6C7" modified="2016-11-02" version="1">MTSTPQTVQSTTLSNSIPERPLSAPPRTSTPPPPPPSRAIPKDFKSSLSAWWSTSSYKEARLAEERLLRRMSNFEPSSNLQESQKGWFGFGSSATATAAGQKYEIDNKIPIEEIGQIKEPIPITNSGLVATLRNVFIPTPNPNLAPQHPADPRDLTSESAASSSTDLSENTSATRKKHHHIKKCKNNEDGKLVDYINTLEITKPQDRDSKEGVVVLHGYAAALGFFFRNWESISLSSSTTGRRTFFLDWLGMGLSSRPSPNLLNPPSNSTIPNRVSRAEHFFVSSLESWRESVGLEKMVLVGHSLGGYLASAYSVRYPERVSGLILVSPAGIPHGPEYVKYPLTSELSSKEKINLDISNRNRRNSRERETSQELEEATNAAEAEFEPNTPKGEAKDWARKREESMLRRGMMKFFVWGWERGLSPFMFLRNAGPFGPLWVGKYSSRRFAAQSEEDVRDLHSYIYGTSIMKGSGEYCISHILAPGAYARIPIIDRINRLKVPVTFMYGDNDWMDVQGGNDSVKALKEAGNSNATCHVVPKAGHHLYLDNPEYTNKLIGQAIKDIPKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HXH2</accession>
    <name>A0A1B9HXH2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Patatin-like phospholipase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_05832</name>
        <name evidence="10" type="ORF">I206_107504</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PLPL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KI894014">
        <property type="protein sequence ID" value="OCF47966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009185.1">
        <property type="nucleotide sequence ID" value="XM_019157545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HXH2"/>
    <dbReference type="STRING" id="1296096.A0A1B9HXH2"/>
    <dbReference type="GeneID" id="30174201"/>
    <dbReference type="KEGG" id="kpin:30174201"/>
    <dbReference type="OrthoDB" id="15478at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07232">
        <property type="entry name" value="Pat_PLPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021771">
        <property type="entry name" value="Triacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF66">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE PTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11815">
        <property type="entry name" value="DUF3336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="8">
        <location>
            <begin position="305"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="42"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="687"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="830"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="5">
        <location>
            <begin position="336"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="719"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="837"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCF47966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC73532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="950" mass="106304" checksum="5B27C9BAA4453967" modified="2016-11-02" version="1">MPSRMNAPPTQSRRDELLNENYVDEEHLKAFASALSISDTLHMEGEASPLSPRSPPVPLDSPKASNPSSRLQPQQWKYGPDNGSFGSGSGGSGERVEKLTATSDFAPIHQRVSKRPRTSNQGLTYHLIRWPLLGFFFTIIYFEFLTYVITRQVVNVFEWLVAWRGPKVRLRREVRNSKTYEEWIAAAKKLDSNLGFDEWKETDEDSYFDYTLVKRVKRTLTKFRAAEDARGLMDALAVCVRSNFAGTESVKMYSETFFGTKRLIEDHVNEVAACLDFVRTAKDVSLEEKRAFFRAINRHYGASALCLSGGASFGYYHFGVVKAFLDADLLPRVITGTSAGGLIASLLCTRTDDELRELLVPELADKITACEDPFHVWFKRFRQTGARFDTVTWAKKGMWFTRGSMTFKEAYERTGRALNISVVPSDRHSPTILLNHLTAPNCLIWSANLASAAVPGILNPVVLMAKDRDGNVKPHNLGGSRFKDGSLREDIPLGSLHTQFNCNFSIVSQTNPHIHLFFFAPRGSVGRPVAHRKGKGWRGGFILSALESYIKLDLSKHFKVIRDLDLMPQILQSDWSGVFLQRFSGDLTLTPRTTIRDWFSILSDPDRKQLDHMLEVGQRVTWPALRMVKNRMTIERAILRGRTEVRSAIHRDRTSNDMTSPPKTGGLKVPEIIPLESDVDAGFASRTRRTKGSRGLGGLGITTTFEPESQHGLGLSQTTRRRKNNPRRRRASEVFVVDSDEVEEELDLPSYTRQLNASRSVPPESPSLVKKGYSLNLGDTLRHVRAPSLSALSSPFRSIRQASISPQNEDPPLLPQNPRVKSQLSITRWFGGASDSSSDEDSGEDEYNWRKSQGGVKSATDEDTEEDIIEVKAEPGYGEETIPGGERVTQEQIDEGAAAGRSRRNRSISETTTNSEPSRDGNEGTIEEVANVVRRHELGNTPPQQDGVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HY15</accession>
    <name>A0A1B9HY15_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclin-D1-binding protein 1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_06018</name>
        <name evidence="3" type="ORF">I206_107683</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894014">
        <property type="protein sequence ID" value="OCF48150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009369.1">
        <property type="nucleotide sequence ID" value="XM_019157729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HY15"/>
    <dbReference type="STRING" id="1296096.A0A1B9HY15"/>
    <dbReference type="GeneID" id="30174387"/>
    <dbReference type="KEGG" id="kpin:30174387"/>
    <dbReference type="OrthoDB" id="41588at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026907">
        <property type="entry name" value="GCIP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049317">
        <property type="entry name" value="GCIP-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492">
        <property type="entry name" value="CYCLIN D1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492:SF1">
        <property type="entry name" value="CYCLIN-D1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13324">
        <property type="entry name" value="GCIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-D1-binding protein 1-like N-terminal" evidence="1">
        <location>
            <begin position="50"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF48150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC73711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="322" mass="36402" checksum="D9CD631DE7CC15E6" modified="2016-11-02" version="1">MPDPLDPNLQKALTESQKIILISLKALTSQSSSSHSSSSSSIQSGLGDAFQQLLNQLRQSITVLGLSFNPPITIKAAIKELNKISENIGQLISCILISNLSSLLFEEWKFGIINIIEEVIKHIKVLENQDDYLSSTGKVWESIDNLLNDLSKDEQSALRKKWKIHQSTVKDAWSEFKEILENQGDSEDPLNDGWDELDLGGEELSEDERKRAEAAKPLLALHQILHATIPRFINQLTEDQYRPILAISTNFVDAYDDAVSSMHPGQDEPEIEEALIQLEDISRQLAGKIQDPSVDKWVERLEIEQKKWEERRLDLKTLKNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HY20</accession>
    <name>A0A1B9HY20_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">50S small subunit ribosomal protein L24e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_06035</name>
        <name evidence="7" type="ORF">I206_107701</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894014">
        <property type="protein sequence ID" value="OCF48167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009386.1">
        <property type="nucleotide sequence ID" value="XM_019157746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HY20"/>
    <dbReference type="STRING" id="1296096.A0A1B9HY20"/>
    <dbReference type="GeneID" id="30174404"/>
    <dbReference type="KEGG" id="kpin:30174404"/>
    <dbReference type="OrthoDB" id="1727108at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000002">
        <property type="entry name" value="60S ribosomal protein L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL24-related N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="109"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCF48167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC73729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="147" mass="16574" checksum="69FF323205523B69" modified="2016-11-02" version="1">MRVDRCDFSGYKVYPSRGKVYVRGDSKTFRFLNHKSESLFLQRKNPRKIAWTQVYRRMHKKGITEEVAKKRSRKNVKVQRGIVGADLASILAKRTAKPEVRAAARAAAITKAKTEKRDKETAKVANRGQSNAPKVSKQAMKGGKGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HY36</accession>
    <name>A0A1B9HY36_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_06050</name>
        <name evidence="9" type="ORF">I206_107716</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 5"/>
    <dbReference type="EMBL" id="KI894014">
        <property type="protein sequence ID" value="OCF48182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009401.1">
        <property type="nucleotide sequence ID" value="XM_019157761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HY36"/>
    <dbReference type="STRING" id="1296096.A0A1B9HY36"/>
    <dbReference type="GeneID" id="30174419"/>
    <dbReference type="KEGG" id="kpin:30174419"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044609">
        <property type="entry name" value="FKBP2/11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779:SF7">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628184" description="peptidylprolyl isomerase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="45"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF48182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC73744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="141" mass="15759" checksum="FD136CDC679A5379" modified="2016-11-02" version="1">MYNPKALIVTLLFSLALVLAAKSTDQLQIGIKYKPEECPIKSRKGDKLSMHYTGTLAKDGSKFDSSLDRNQPFEFTLGAGQVIKGWDQGLLDMCISEKRKLTIPHELAYGERGHPPVIPPQSTLIFEVELLGIKNRFVDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HY51</accession>
    <name>A0A1B9HY51_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosome biogenesis protein BRX1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_06062</name>
        <name evidence="8" type="ORF">I206_107728</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BRX1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894014">
        <property type="protein sequence ID" value="OCF48194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009413.1">
        <property type="nucleotide sequence ID" value="XM_019157773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HY51"/>
    <dbReference type="STRING" id="1296096.A0A1B9HY51"/>
    <dbReference type="GeneID" id="30174431"/>
    <dbReference type="KEGG" id="kpin:30174431"/>
    <dbReference type="OrthoDB" id="1638493at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000009">
        <property type="entry name" value="Ribosome biogenesis protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026532">
        <property type="entry name" value="BRX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13634">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13634:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BRX1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Brix" evidence="6">
        <location>
            <begin position="38"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="267"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCF48194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC73756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="297" mass="34186" checksum="FF8149E7522B0FB8" modified="2016-11-02" version="1">MATLLKNATEIQKGKNKKSKDNATAGPSEEKTYKPRKDKTLLLCSRGVTQRMRHLMRDLEVLLPHTKKDSKLDTKSSLHLINELADLHSCSNTLYFEARRHEDLYLWLSRSPNGPSIKCHVQNIHTMDELKMTGNCLKGSRGLVSFDGSWDNEEHTKLLKEVLTHTFSVPKTSRRLKPFIDHILLFSLLDNKIWFRNFQIIEKDPLTPTGPPIPSLVEIGPRFVLNPIRIFEGSFGGSTLYSNPEFISPAATRASIKRDAGQKYKIRKQNEIERDQRQKRIREELPEDQLSRKKVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HY85</accession>
    <name>A0A1B9HY85_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_06107</name>
        <name evidence="8" type="ORF">I206_107774</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI894014">
        <property type="protein sequence ID" value="OCF48239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009458.1">
        <property type="nucleotide sequence ID" value="XM_019157818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HY85"/>
    <dbReference type="GeneID" id="30174476"/>
    <dbReference type="KEGG" id="kpin:30174476"/>
    <dbReference type="OrthoDB" id="2566866at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd03386">
        <property type="entry name" value="PAP2_Aur1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052185">
        <property type="entry name" value="IPC_Synthase-Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310:SF7">
        <property type="entry name" value="PA-PHOSPHATASE RELATED-FAMILY PROTEIN DDB_G0268928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="Mohammad A.W."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="Springer D."/>
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                <person name="Gargeya S."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="Dromer F."/>
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                <person name="Zeng Q."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
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    </evidence>
    <sequence length="1046" mass="115399" checksum="40E806CB64EA2DB7" modified="2016-11-02" version="1">MAPSMFTRPSVVSDNKGSTALHRQKFRSISSFFHSTTTTSVEDNELHVIAYFQPQDNSPAHPTYDGLPSIRNASAISLSRAIPSPSQSTASFRLKAEIHKENVGVSYTSHTLQAQVSREMPTLASAIHIPDSTTSTKTFKPQHSTLPSPGNNAVHPLYHINASSTSIFDSYVHVAETVEKDHSNEDSENTLRRKLSRRLSLDLIVPKLTGSLRKRERSGSKSSTFDKDNVDSSRRWSLFNNSENKATQIEAKPFPVPPVNKMQAGMPVTRNWRNKFTVHKPSTELLGDKKEDIGSRLEASRQARERTMADSISTTERYDERTIKRIPVKRMEDRSSSDIQAKCVEDKLRQRQSLISMKASTMKDCQDASRFSFVHRPSSIASTFDPAATPKSTASSIPIPFVPTGPPLIESQTVTSLSATFDSPSPLPRPLHTPSTRSNGLHVPQTTKMSIFSPAQDDRSILDPGRSPCPLPDGSPLIPSDGLRYQHMPLPDPPIQQNLTSSPSASGIGGRKDVLSASESAVSMAISATQPSQTGTFGVTKNHNTSHTNLEGSATSTDRSHMTSSSSSRTIYTLPRSKSKSHTDLSTYASSKNLVDHIEATQGPGWWSADKRASRKESVATTQEEVEQKTIERLERLAQSTNLPHRTKFDGQECQVDTDHLLNTSLNRMRAEDKMRTRSSMDLGSSYRATGHQARHSLVAGSIWSKDQSSSPRRSVLTNQSRILDAAGTPVKIVHLALIPLPPSEIKKGTFVSNRISPEIARRASFLNKSAVNTAITDDNSSDSPSRSTSRQTTRTVGSIISNVSTVPTSLQSDGEAEDDKLSNGNQGVKIQQLIVEYEEKLKNMKSRHALEVDTILNALSQSKNDNQLLKTDNDRLFVENNKLKEKVKILCMSLQSIELGSSTEQCDQPRLTDNQISMKRSESTMSSLLPELNSTNSMQLSPLPYTSRTSSLGSSSDQYEIDEFGRKNLSTSKSSMKNDRKTSDFSGGEKTVLVMEKRNVSGQSYTTEGSIISYEDHQTQQISDIVNEGWTLSLKEDDKRFLNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HYI8</accession>
    <name>A0A1B9HYI8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_06213</name>
        <name evidence="2" type="ORF">I206_107880</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894014">
        <property type="protein sequence ID" value="OCF48345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009564.1">
        <property type="nucleotide sequence ID" value="XM_019157924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HYI8"/>
    <dbReference type="GeneID" id="30174582"/>
    <dbReference type="KEGG" id="kpin:30174582"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCF48345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC73908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="225" mass="25488" checksum="02B81A7DF3977FD0" modified="2016-11-02" version="1">MWMHLLNIKSLDEWCYRIFSKAGPVRIDFVTASKPILEDKVSSSSTTATTTTTLVHRVCLPRLVMGTLQDTPFPILQCLVELAQESQDMVASAIKFLEKKPGQEAKLLADKWRKLFTDYTRGYHSALIQTERPGEIHQPKPTATQAHISNIVHSSPPRIGTELLHSSMSPSRIERTLIEAINDTFSVVQQYIREKEEVFDKLLADTGMEVEVVAWRKIQEILSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HYJ4</accession>
    <name>A0A1B9HYJ4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cell division control protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_06204</name>
        <name evidence="3" type="ORF">I206_107873</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894014">
        <property type="protein sequence ID" value="OCF48336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009555.1">
        <property type="nucleotide sequence ID" value="XM_019157915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HYJ4"/>
    <dbReference type="STRING" id="1296096.A0A1B9HYJ4"/>
    <dbReference type="GeneID" id="30174573"/>
    <dbReference type="KEGG" id="kpin:30174573"/>
    <dbReference type="OrthoDB" id="5357220at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012535">
        <property type="entry name" value="Cell_div_Cdc14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34065">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34065:SF1">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08045">
        <property type="entry name" value="CDC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="458"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="523"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF48336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC73901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="750" mass="81442" checksum="E1117F2D1907C2C3" modified="2016-11-02" version="1">MLRPQGHRKSQSTSALSFLANQDRSSSSSNTSDQSSSRHNKAQDETKGTYRSRQSLLPSVRESESSAASMTILPRITASRRSSQISLVMDDDLTKKSSGQSQRSNRSKSHSAAEVSRREKSTTEAMKREKSIENGLESWLSDLKSLRSSARRRLSALKHLEKRLVEICLGQSQSEIGDLLSRQIHNILLSLLTRYTSTLSQRSSHTSLPAKDEVAYALIPEIETIASILQGLCCLSRTCKETMGEGWVMEMFIDLLLLLRSQPPLTDNSKAIAYTILELLFCVLVDSPKNARTYEKLGGLEAVVRVLKGTGVTKDVRMKCIEFLYFYLLPEQNDSQRVVSCASSSSSSSTESTLFPPSPLSTSQAFMEPPSISHTGRISPGHPRELADIDMPFVPMTPRKAPQPNLGYLTPATRKSSVCISNSSTPSLPTVPASPRMPISQSTTSRGLAAMLDEMDDSTCPTPRSSRSSRATSDDEKSGVGLGLGLPKISSGLVRSNTTQRYLSSMAAGKESTAFIDPFNLSSTSERSHSGSSGSSTVVPTTASRSISRSSTQPSLTITDSNGLPRSPSTTSTIGIPRRTSVRRVSKSPLIHSSLPESPEKQSPRSPKIRHSRTQSHLSGLNGMRKSSIPPVPPLPMSNEQTTRTPSNKSRAFPAELTRGIPPSASSPSLAGGMTPLGASKRVISDKKNLQSSTRKDRSIEEKKKLKDVKSVEEKKEMLGMWLGNVDQLVQGVEKVSFWGSIGNGARAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HYM2</accession>
    <name>A0A1B9HYM2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">precorrin-2 dehydrogenase</fullName>
            <ecNumber evidence="1">1.3.1.76</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I206_06206</name>
        <name evidence="15" type="ORF">I206_107875</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
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                <person name="Sun S."/>
                <person name="Springer D."/>
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                <person name="Young S.K."/>
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                <person name="Berlin A.M."/>
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                <person name="Hansen M."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Roberts A."/>
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                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
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            <authorList>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
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            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
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        <text evidence="9">In the N-terminal section; belongs to the precorrin methyltransferase family.</text>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
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                <person name="Alvarado L."/>
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                <person name="Chapman S.B."/>
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                <person name="Goldberg J."/>
                <person name="Griggs A."/>
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                <person name="Imamovic A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
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    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <property type="nucleotide sequence ID" value="XM_019156387.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A1B9I0A9"/>
    <dbReference type="STRING" id="1296096.A0A1B9I0A9"/>
    <dbReference type="GeneID" id="30173026"/>
    <dbReference type="KEGG" id="kpin:30173026"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF48970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC71878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="472" mass="50793" checksum="2C54A35E323A672A" modified="2016-11-02" version="1">MPPRLLACGSNAASHLSINHPDDVSILTPTIYHPSLPSFSSESQILDLVSTSAHSLLLISPSSAGGDRPGKNILLGAGTNTFGQLGPRCALWNDIKPESKWKPLNLLNSAEIDDKEEWEPVKIAATWTTSFIVYQRSKSFKARQCESSIGGSGLNGKIDPIEDQKIEQIVISCGSNDFGELGSSSNFPLTLNAPSEIPISQASQKPTIVNLGLQPGERIELIKGGQRHVIVVIVNGDGKQRVMGWGASRKGELDAKTLSSCLESDSSSSSMFYSNKGKGKGKGKAVSRSTSSPPIAIDLPISSKAKIVDISLGASHNLALLSDGTVMGWGNNLKNPITDVHTLRNIKSIATTWNGSYFLNDQNEVFAQGSNTHSQLLRLGCEEISAKMGKIDIPLGWKVEKLVVGSEHLLLKLKREETGGETLWTGGWNEHGNLALGDNNDRPSLERVDLQGKIKGLWGGCASTWVWIDEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I0F3</accession>
    <name>A0A1B9I0F3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">H/ACA ribonucleoprotein complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_04706</name>
        <name evidence="11" type="ORF">I206_105886</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the GAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC71927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010238.1">
        <property type="nucleotide sequence ID" value="XM_019156436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I0F3"/>
    <dbReference type="STRING" id="1296096.A0A1B9I0F3"/>
    <dbReference type="GeneID" id="30173075"/>
    <dbReference type="KEGG" id="kpin:30173075"/>
    <dbReference type="OrthoDB" id="2187159at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034513">
        <property type="term" value="F:box H/ACA snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000454">
        <property type="term" value="P:snoRNA guided rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.230:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237:SF6">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237">
        <property type="entry name" value="NUCLEOLAR PROTEIN FAMILY A MEMBER 1 SNORNP PROTEIN GAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="129"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="144"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF49019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC71927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="221" mass="21968" checksum="BF8AED71F9982ECA" modified="2016-11-02" version="1">MSGRGGFSGRGGGDRGGRGGFRGGGRGGRGGFGQRDFGPPETVQEIGSFLHPVESEMLCSLITPTKIPYFNAPIYLQNKTQIGKVDEILGPINQVYFTVKMDQGMIANSFKPEDKVYISGEKLLPIERFLPKPKTAGGKERGGARGGAGGRGGGRGGRGGPPGRGGRGGFSSRGGGGGGFSGGRGGSRGGFGGGRGGGAPRGGSRGFGGGGGGGGRGRGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I0Z8</accession>
    <name>A0A1B9I0Z8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Gly-Xaa carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">I206_04882</name>
        <name evidence="18" type="ORF">I206_106059</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010413.1">
        <property type="nucleotide sequence ID" value="XM_019156611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I0Z8"/>
    <dbReference type="STRING" id="1296096.A0A1B9I0Z8"/>
    <dbReference type="GeneID" id="30173251"/>
    <dbReference type="KEGG" id="kpin:30173251"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05674">
        <property type="entry name" value="M20_yscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000098">
        <property type="entry name" value="Gly-Xaa carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017141">
        <property type="entry name" value="Pept_M20_carboxypep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047177">
        <property type="entry name" value="Pept_M20A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE/HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962:SF1">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE_HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037217">
        <property type="entry name" value="Carboxypeptidase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="16">
        <location>
            <begin position="286"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="571"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OCF49194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="WWC72099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="603" mass="66007" checksum="18FFDB74FB910A44" modified="2016-11-02" version="1">MAKGPIHLPVHSLEHSPERGRARKSWPLAVIGLLATAAVLTSFPTSVTQLTSNATSSFFEGDLSVKKGLCEQAEPFLPSGYNVTKIWEEKDVIIKRLQEAIRIPTQMYDEMGPVDEDPRWKIFAEFHDFLERTFPNVYEHAKVTKTDWALVYEIDGTDSSLKPLMLTAHQDVVPVLPDTVGQWTHDPFSGEYDGTSIHGRGSSDTKSSLIAVMSALEHLFGTTDFKPRRPIILAFGSDEERGGQVGAPAIAKFLLEKYGKNSMSLLIDEGNGLVETWGQQFATPAVAEKGHVDIGITVSTLGGHSSVPPTHTAIGLISLLIAQLEAHPHQPTISEKSPIYEFMTCAATFAESMPAKLKKVVIKAGKGDKKAWKQLPLEIINTGMEGSSHGPGQGDPLRSLLTTTQAVDIINGGLKVNALPESVKAIINHRINVLSNHLELQERIETLLLPIVKTYNLTLNGFDGTTVFSGSPSSKVDLNLAFGYFTDPAPHSPVTLDDPAWNVLAGTSRGVWASRKEVSKDGSVVELEKGKDLVMAPFMSTGNTDTRRYLDLTPNIYRYRYTPMEGSAGAHTINEYSNANDLIEFTRFYQAIILNMDQSKDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I1N4</accession>
    <name>A0A1B9I1N4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein HRI1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_03971</name>
        <name evidence="2" type="ORF">I206_104448</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010669.1">
        <property type="nucleotide sequence ID" value="XM_019155711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I1N4"/>
    <dbReference type="STRING" id="1296096.A0A1B9I1N4"/>
    <dbReference type="GeneID" id="30172340"/>
    <dbReference type="KEGG" id="kpin:30172340"/>
    <dbReference type="OrthoDB" id="4045395at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.320">
        <property type="entry name" value="Protein HRI1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031818">
        <property type="entry name" value="Hri1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043047">
        <property type="entry name" value="Hri1_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16815">
        <property type="entry name" value="HRI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCF49450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC70497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="24684" checksum="4B0E187A6043B3DE" modified="2016-11-02" version="1">MSARVSTRISIAWSGAEPIEDTDTLVLTIDGYSLDLRVFLEGLDKGSMDWSTVAHVGEIEGSTKEKPKLRWDHIIDNRPETEMPDQGVFDTLSNGDVTETGTMFNPKTNLYEPYVETWRRKQLPSRTPYFVVASQQKDVQSYIGRVGDYALGLAKDARGDYYAWRDQLEQGHWKRIYEFGQVNKYLPQLPSEVSQDWAKGGSTILGGVTWDIKVVGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I1P3</accession>
    <name>A0A1B9I1P3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydantoin racemase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_03965</name>
        <name evidence="3" type="ORF">I206_104454</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HyuE racemase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010663.1">
        <property type="nucleotide sequence ID" value="XM_019155705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I1P3"/>
    <dbReference type="STRING" id="1296096.A0A1B9I1P3"/>
    <dbReference type="GeneID" id="30172334"/>
    <dbReference type="KEGG" id="kpin:30172334"/>
    <dbReference type="OrthoDB" id="412018at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047661">
        <property type="term" value="F:amino-acid racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052186">
        <property type="entry name" value="Hydantoin_racemase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053714">
        <property type="entry name" value="Iso_Racemase_Enz_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28047">
        <property type="entry name" value="PROTEIN DCG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28047:SF5">
        <property type="entry name" value="PROTEIN DCG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF49444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC70503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="26168" checksum="97AEB98AA648D06F" modified="2016-11-02" version="1">MSSPLTRSEMSSHTSTSILVVNPNSSFSITRAIKQSLEPHIPLGVTAEFFNPSTGPAGISDPATAQSSCEACMEELPGLVDKYDGVLVACFSDHPLVPTLELYAKDKNLCLSVLGIYHAGIATALLRTRGKFGIIATGSGIKTNLIEATAKFLGSTTSDRFVGPITTDISVVELQEGDQVEVERKMRSTTRDLVRKGAEVIILGCGGMCGMEPWIVDSAAEEGRQVQVVDGARMGFHMILALIHGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I227</accession>
    <name>A0A1B9I227_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytosolic Fe-S cluster assembly factor CFD1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_04128</name>
        <name evidence="11" type="ORF">I206_104295</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010825.1">
        <property type="nucleotide sequence ID" value="XM_019155867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I227"/>
    <dbReference type="STRING" id="1296096.A0A1B9I227"/>
    <dbReference type="GeneID" id="30172497"/>
    <dbReference type="KEGG" id="kpin:30172497"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002132">
        <property type="entry name" value="Cytosolic Fe-S cluster assembly factor CFD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03039">
        <property type="entry name" value="NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028600">
        <property type="entry name" value="NUBP2/Cfd1_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF19">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="25"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF49606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC70345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="335" mass="36835" checksum="D4E4770744910DF2" modified="2016-11-02" version="1">MSAPIETPVSRRLASVKNIIIVLSGKGGVGKSSSSVQLALSLLSQSPSNRVGLLDLDITGPSLPRMVGLDLPEATVHQSSAGWVPVYVDSEKRLGVMSIGFLLKDRGDSVVWRGPKKDGMIRQFLSEVRWGELDYLVIDTPPGTSDEHISLLTHLHPLFIPNNLKPTTPTSILITTPQITSINDTIKSLSFTKKLNLPVMGLVENMSGYVCPCCNEISNIYGDQNKVFELSKKENLNYLGKVPIDTNLVKLLDSVSKGEIPITSQINSSNQQNQNEVGDGIVNINGLEGEQSQFPLLDKYNDTTSSKVWKEITDNLIEKIEERKNQIKQNLESQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I248</accession>
    <name>A0A1B9I248_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I206_04049</name>
        <name evidence="15" type="ORF">I206_104371</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the proteasome inhibitor PI31 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010747.1">
        <property type="nucleotide sequence ID" value="XM_019155789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I248"/>
    <dbReference type="STRING" id="1296096.A0A1B9I248"/>
    <dbReference type="GeneID" id="30172418"/>
    <dbReference type="KEGG" id="kpin:30172418"/>
    <dbReference type="OrthoDB" id="68090at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045128">
        <property type="entry name" value="PI31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013886">
        <property type="entry name" value="PI31_Prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021625">
        <property type="entry name" value="PI31_Prot_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13266">
        <property type="entry name" value="PROTEASOME INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13266:SF1">
        <property type="entry name" value="PROTEASOME INHIBITOR PI31 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08577">
        <property type="entry name" value="PI31_Prot_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11566">
        <property type="entry name" value="PI31_Prot_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PI31 proteasome regulator N-terminal" evidence="13">
        <location>
            <begin position="25"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="PI31 proteasome regulator C-terminal" evidence="12">
        <location>
            <begin position="272"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="59"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="223"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="324"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="378"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCF49528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WWC70420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="428" mass="44517" checksum="EDB9621BA9756956" modified="2016-11-02" version="1">MSSPNPLNPTNLLKLIHQLLPKSTSSPLTHPTDSIAVLIHAIHISLRFRIIQSAPTSSAAESSAQPIISTTEAEGDDVDDGASETTTAVDADEDSTSQPQEGTLNTGWNDRGEDAYSLQYRHEQSALSFRIRIGRMGNRVQVDAMAEDGQPHNLSIVLSDLIDSSKFPVPSHATSSDTFNTVEGEDLAQKWGFIALANVKNFVEKYKSEIIVRLLPGLQIPGYEETRSSGSGPRNPPPSAPSHQPPPARPQPPTNPLIDPLRDPHPNNPASVGRRDLDPLASFQPPGQFNPNRDGGGMLVDFNHPLFDRRRQGLDPDFSGPGGSIQPPGSRWDPVGPSGTGGGFPGPGGNPLGGRGLGDDRWGDELPPPGEFGPDLGRFGGQGGPRRGGGPGGPGGLGGGFGGLGGGRNGGGFGGGFGGSGGGGGMFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I2A7</accession>
    <name>A0A1B9I2A7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_04191</name>
        <name evidence="3" type="ORF">I206_104231</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010888.1">
        <property type="nucleotide sequence ID" value="XM_019155930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I2A7"/>
    <dbReference type="STRING" id="1296096.A0A1B9I2A7"/>
    <dbReference type="GeneID" id="30172560"/>
    <dbReference type="KEGG" id="kpin:30172560"/>
    <dbReference type="OrthoDB" id="3361363at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
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        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
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            <end position="208"/>
        </location>
    </feature>
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        <location>
            <begin position="209"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="295"/>
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        </location>
    </feature>
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        <location>
            <begin position="323"/>
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        </location>
    </feature>
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        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="359"/>
        </location>
    </feature>
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        <location>
            <begin position="387"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF49669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC70281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="420" mass="45715" checksum="11B7EEB1FE748F65" modified="2016-11-02" version="1">MSYESPVPTPSPHRTTFDTRLAYIQSQNSIPSGSRSSSYRDEPNPEHQNNLSSSSATQLRIPTRPPNIISHPGCVLCSLVSSTFDQLSSSSPLQSPNARSSLLPPSGGDSTSSYHHPFERSSSPSPIPRRLNTGGKDVVHQDSYITVYKAEGKEKLCSDGRHLIVVVNKHLESVYDFGPSDVPLLSHILEVTHRLLSRTPGQSNTSASEAERGKGKEKENDVRVGFVGSVKKDPQSPHPHLHAHAMVGPIDTSLPGATFWRRNVIFGSMNWWGIEDLRAEIREESSNNRVKSGYQHRDKAPIDRVPDAGSIAGLPNALDPSDYTDQSPPTSASKSDHASRTHSYSDRPNSALRNSTSPVETLGPRGKGKQVDRSGSGDADTFRGSEESEEDYVAVDLEDLPFGDKKANAPASRVERGGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I2L9</accession>
    <name>A0A1B9I2L9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cyclohexanone monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_04269</name>
        <name evidence="7" type="ORF">I206_104156</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010964.1">
        <property type="nucleotide sequence ID" value="XM_019156006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I2L9"/>
    <dbReference type="STRING" id="1296096.A0A1B9I2L9"/>
    <dbReference type="GeneID" id="30172638"/>
    <dbReference type="KEGG" id="kpin:30172638"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF12">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCF49745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC70206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="576" mass="65363" checksum="21CC8C880DAB21FD" modified="2016-11-02" version="1">MSPIAINEAVQEELRATPKAPLKQEMKDENESTRPKVCPTVDEPFSERNADGSYKVLNQPLGMRRKLRVVCVGAGASGINMAYKIQSHMKDVDFVTYDKNRDVGGTWLENTYPGVACDTNSHGYAFTYHLKADWTAVFSPGAEIEEYMRDVVRSYGLAKYIKLNHQVLGAQWDAETAKWHVRVREGDDPSTEFTDICDIFINASGLLNHWKMPNIPGLKTFKGPVIHTAAWPEDLDLKGKKVALIGIGSSAIQVLPQIQPLVKSCSIFIRSPTWIAPPREGELLSPEQIKHYLDHPEEHLEYCRDLESLANKRFGYITRGSEDQKNLYQAWSKSMEDGLKSRPEYYDKLHPSFGVGCRRPTPGPGFLEALTQDNVEAVFSGVDHIDENGLTTSDGDQREFDIVICATGFDVSFKPRFPVIGKNQINLQEQWSNSPRAYLSIFATNFPNYFTMLGPGSPSAQGSIIVSIERISDYIIKFLNRFQHETIKTFEVQQNALDELTEHMQEQLKLTVWTDNCSSWFKNGDANGPVIALHPGGRLHFFSLLMDPRYEDFNYTYWNKNRFAYWGNGYTLREVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I384</accession>
    <name>A0A1B9I384_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_04543</name>
        <name evidence="3" type="ORF">I206_103884</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF50012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC69940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011231.1">
        <property type="nucleotide sequence ID" value="XM_019156273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I384"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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            <begin position="44"/>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="182"/>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="332"/>
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        </location>
    </feature>
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            <begin position="380"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="EMBL" id="WWC69940.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1159" mass="122099" checksum="60CE22DAF5BD1BF1" modified="2016-11-02" version="1">MKVDLAVTEARLCNDLFHIQPLSHTITTTVASKSICKPDDSLTPPSGNSRSSSPSGGQGGQPRIVSGSLKDRIAKFNNPSAPPPVPRAHFARQEPSISRGGLVGNRIPSLDPKTAGMINSGRDHPNEKRRISENRGLIGNRIPSMGNQNNVVLLQNQSTGSSGTGTNTPSSATIPKPSTTFAAPGARSASPSGSIGSSAAGTFESSNSPITSRSSSPPTSPGAGLPPSLVAASLPVLDGTATPSSTRAEQGDNVSELSLSVPSTPIATGTPPLPAPEYDLVASNLKLATANASAANPMIRGLSAQSSASKNFAPSISSSLATQSRGSEEETSMMQDVSGVSTPIGTPRAARRELGEGSVVGEGSVVGEGSVMGDNDVEELGNKLEKLEVKKEDTEAAEPTSEPPKDKSVRQQMFDNLPEEAVVADEGSSLADGPADDASNESVNGDETEGEAQSQPTINVSDSSADPNVSSDLDDLKAGKLSSAPKSELNSDKSHDKKEDPNLAPDLADLKAGRLSPAPVSEPNPADKRSEEQPDSYHSKDKHDPNQAADLDDLKAGKLGAAGDENRQESGPPDQPSRDIGLSIPANAMAGDTYTQGIAEHPIAEDEVKEQGGEAGQHMDDVETADQVIEPGETENQDISNYDGGINETEETVYVGPGEMEAKEGGAKKNIAGSTQWFESEYKQKHIERGSSHEQQNTESNNAYQQDEPKNGDPDLINPTYKGDDSKSAKEDPYKPEFKPPTLQEAGKPISQLDNDPQARKDQEEKNPTKRPIEPEHYISPQEKDEKDEQKEQDMDAEEVTSSAADDVDNGERTQATEVEAPPTPLSANPAGVQTSEEEDKSSPSSARTETPSTPKPNTLHIGEGLQTESDQPPVTAIGAEATEDQITSRSADEPKQLHIEPAPIAQPASAESAESIDKSSHTDQEGVESQKEGVDESTIGSGAKTPSFPDPPTADPDVEDPITSPGELEIPNSEGGHSGFATPIDGQFLKSFPDVPDEDKPRVQVHVSSPVTTPQKPSAATAHTPTDSITHNPSDVDLDLPENIKNVKKNYIERKGPGDGEAIEIPDDFPSTPVANIPGKSKPLREGLSVDKTNTPEASSRKASEQEDLDATPQQQFRSSGSLSKRLSARRSPKSPLLDDEDPGDFEPGEEGWAVVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I3G2</accession>
    <name>A0A1B9I3G2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glyoxal oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_03397</name>
        <name evidence="7" type="ORF">I206_105700</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011299.1">
        <property type="nucleotide sequence ID" value="XM_019155145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I3G2"/>
    <dbReference type="STRING" id="1296096.A0A1B9I3G2"/>
    <dbReference type="GeneID" id="30171766"/>
    <dbReference type="KEGG" id="kpin:30171766"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009880">
        <property type="entry name" value="Glyoxal_oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208:SF21">
        <property type="entry name" value="LOW QUALITY PROTEIN: ALDEHYDE OXIDASE GLOX-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07250">
        <property type="entry name" value="Glyoxal_oxid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="GO-like_E_set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628305" evidence="3">
        <location>
            <begin position="20"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="Glyoxal oxidase N-terminal" evidence="4">
        <location>
            <begin position="94"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose oxidase-like Early set" evidence="5">
        <location>
            <begin position="488"/>
            <end position="596"/>
        </location>
    </feature>
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        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCF50080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC71742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="670" mass="72154" checksum="D5119E96A88AA829" modified="2016-11-02" version="1">MPSLNLFTLITLLPLLVFASTDSKPRWRDPAAPPLGLKKRDGNSTATPLNFESVGDTGVSAQMVFLGNNKKIYVLDKTENNPVEITGQYGTHPAWATEYDIESNEYRTMDVFSNTFCAGGGVLGNGTWVVFGGNQPVTTGGVASTAAEAYSDTDGGTAIRMLNPCTDESCEYIQGETSYSTSADNTGGYLQMTGRRWYPMVEALPDGSLIIIGGDKNGGYVNTQAQDNPTYEFFPPRADDPQDLQFLADTLPINLYALTWLMPSGKLFMQANRKTILYDYNNKTTTNLPDMPYAARVYPASAATAMLPLIPDNGYAATLLFCGGSATTQWGNDGTAGYNVTAVPADDTCVRITPEGSAVYEDDDYMFEGRSMGQFVMLPDGTFWMGNGVGMGTAGYGDDDYSVGQSYGQAPVYMPAIYNSSAPQGSRWNRTGLVASTNERMYHSTAILLPDGSLFIAGSNPNKDFTTAQWRSRTDSERWYPWYYNEARPIYEGFQDTLSYGGNSFNISLNSTDSATAQNTKMVVIRGGFNTHAIGFGQRYLQLNSTYEIDMNTGKTTHMVSQMPGGSTGPNLFQPGPAMFFVVVNGVPSQGEFVMIGSGKIETQATQTNQDLPSSTVIAVVQPENTTEANSSSGSSSKSGTSGAFSTFSINHATLGASIIATLIAFTSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I3J8</accession>
    <name>A0A1B9I3J8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Triosephosphate isomerase</fullName>
            <ecNumber evidence="6 11">5.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_03419</name>
        <name evidence="13" type="ORF">I206_105679</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="6 11"/>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011321.1">
        <property type="nucleotide sequence ID" value="XM_019155167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I3J8"/>
    <dbReference type="STRING" id="1296096.A0A1B9I3J8"/>
    <dbReference type="GeneID" id="30171788"/>
    <dbReference type="KEGG" id="kpin:30171788"/>
    <dbReference type="OrthoDB" id="6715177at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046166">
        <property type="term" value="P:glyceraldehyde-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000025">
        <property type="entry name" value="Triosephosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139:SF41">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="Triosephosphate isomerase (TIM)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 11 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCF50102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC71721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="251" mass="27167" checksum="5376C8F5A0DD9936" modified="2016-11-02" version="1">MVARKFFVGGNFKMNGSLKEIETIIERINEAKFDGEVELVVAPPALYLLKIQEELKPPAQVSAQNSYTEKSGAFTGEISPNQLKDANVHWVILGHSERRSLFGDTDKLVADKTKAAVEAGLGVIACIGESLQEREADQTQAVVERQLEAIANEISESEWKDIVIAYEPVWAIGTGKVASKEQAQEVHANIRQWLAKKVSQTVADQTRIIYGGSVNGKNSGDLATAADIDGFLVGGASLKPEFIDIVNSGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I3M7</accession>
    <name>A0A1B9I3M7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Proline dehydrogenase</fullName>
            <ecNumber evidence="2 5">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_03453</name>
        <name evidence="9" type="ORF">I206_105647</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Converts proline to delta-1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proline oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="2 5"/>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011353.1">
        <property type="nucleotide sequence ID" value="XM_019155199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I3M7"/>
    <dbReference type="STRING" id="1296096.A0A1B9I3M7"/>
    <dbReference type="GeneID" id="30171822"/>
    <dbReference type="KEGG" id="kpin:30171822"/>
    <dbReference type="OrthoDB" id="5464at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914:SF0">
        <property type="entry name" value="PROLINE DEHYDROGENASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PROLINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proline dehydrogenase" evidence="7">
        <location>
            <begin position="162"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="23"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF50134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC71689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="601" mass="65577" checksum="FA93987B26A564BD" modified="2016-11-02" version="1">MSISPLLARSSRVLSRTSSRLISRYTPSSPSSSSSIRSLVTPTSSGSSSNGKSSSRKYLPYALIGIPASLLIMPTISAESPSDEDKPVKPLSSLEASSLSSLIRSYLVYTLICTPGLVDYSPTILHSFTHSFIPGLKGITEYIVRLTFFGQFVPGETVEECLPTMSNLHERGVGSMLNYSAEADLGASPAEEVDLEEQAREERLQEVFRALQKSGEFEKSLPERDRGATSFALKVTGLIDPPILTRASTTLLRCRPLTYSAQPISANSPPQVPYPGTPQSTDARIVARDPSMGDGKELLSLNGVLGSMGVLNTDEGLRKGDLEELSNLWGKLKKIGQAAKDNGIVLLVDAEYTWMQPALDAYTTLLSAEFNIPPPKGSEEFKSWRGPLIYGTYQSYLTRQPTHLIAALKHAEDNGYALGIKLVRGAYFDKERKKWKNEGREGADPIWPDKSATDSSYNGSLNTVISTLSTQLASKKPELALSVIFGTHNPDSCDLICDGLKQVGLATELPDGRLQLREDVQGKVGVAQLYGMKDDLTDKMAAKFVFDGRPIAIKYIAYGKLAEVMPFLGRRAIENKSLMSGDQGAAAERRRVGSEIWRRMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I3T2</accession>
    <name>A0A1B9I3T2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial intermembrane space import and assembly protein 40</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Mitochondrial import inner membrane translocase TIM40</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I206_03498</name>
        <name evidence="15" type="ORF">I206_105602</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
            <orientation evidence="2">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011398.1">
        <property type="nucleotide sequence ID" value="XM_019155244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I3T2"/>
    <dbReference type="STRING" id="1296096.A0A1B9I3T2"/>
    <dbReference type="GeneID" id="30171867"/>
    <dbReference type="KEGG" id="kpin:30171867"/>
    <dbReference type="OrthoDB" id="7481291at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039289">
        <property type="entry name" value="CHCHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21622">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21622:SF0">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="106"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCF50179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WWC71644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="267" mass="29757" checksum="730E2C5E0F7478E7" modified="2016-11-02" version="1">MFSRSTIRSFRSLSSQISRRSLSTSTSSASSSTFSRNAAIGITTLAVAGLTITSERRRVLNDDRVRESVLDQGSLKEPIHKREGATKSNNNTDKIKSNTETLSEKAKDVKNQIIEKTQDVKEQIDERFEKVEDETINKIKETKSKVENKTDEASHLIEEKSEEAIQPSQGAFNEETGEINWDCPCLGGMADGPCGEQFKEAFSCFIYSEAEPKGVDCVEKFKHMQDCFREHPEIYGEEIDDDETDLADAPIPADDGVTVEDVKAPFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I3T7</accession>
    <name>A0A1B9I3T7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_03511</name>
        <name evidence="3" type="ORF">I206_105588</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011411.1">
        <property type="nucleotide sequence ID" value="XM_019155257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I3T7"/>
    <dbReference type="STRING" id="1296096.A0A1B9I3T7"/>
    <dbReference type="GeneID" id="30171880"/>
    <dbReference type="KEGG" id="kpin:30171880"/>
    <dbReference type="OrthoDB" id="3345971at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
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        </location>
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        </location>
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        </location>
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        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF50192.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC71630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="685" mass="74324" checksum="92716C1131E6EB0F" modified="2016-11-02" version="1">MSHRSSSPFNPNPPSASSSPRRTGSPLPSRGRTSSPRPPPSYARASLDRSPSLNPMVLDDRPRVPPPIYLRSSSPGTSGKGSMKIHVPAWGVSLVRPPRHLDLHPLEAGSTTLEPPSEDTVLSGSLEVTMKERRRVKAISIGVQSVCRLHMGANRGWEEDGIFERGVEVLGPTDIEMEEGIWLEKGSQSFSFTIILPATLATTDFHNFGRVSYILTAKVEGIQSSTSFSSMFKIASTSSPALDPTIPNVGDFERVLARSDKLVSTGLANRGGHTSQESLVHQTRGLALDINDESQEDPLWDNDAITVGEGPSSVQGLYTRREDPPRPCSHVPPLSLSPDQLPSNPLSRRHSHSDAYAKTEKNGWMKGDLVASKALIVHANPSRTGGVTQLDIRKEGFVDGLGIWRFTANADVFSISSVLLISIKLPAPSSTTTVFLARLILSQSYSIVSPRTPNQPAHSPETSRQHILYQVGRPHKANEKYPGREVEALWRGKDVPGKGKRDEADSGWVIRAVARLPGHDKIRPTTCDGTITPIRVKHEMLLQIFYSVDGRCVHNDPIEGPGELRMMSVKMPIAVPSCCLTLNALDLPTYEVAHSAPTENIDSIISSPPGKNLCMCGSTFAELGEAAMRRMQSVEQDEEDERINQTLNPPPIGSRQSSGNGNGEKDLESRRDSHSGSGPGPSGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I439</accession>
    <name>A0A1B9I439_9TREE</name>
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        <submittedName>
            <fullName evidence="4">Phosphopantothenate-cysteine ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_03607</name>
        <name evidence="5" type="ORF">I206_105490</name>
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        <name type="scientific">Kwoniella pini CBS 10737</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPC synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC71532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019155353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I439"/>
    <dbReference type="STRING" id="1296096.A0A1B9I439"/>
    <dbReference type="GeneID" id="30171976"/>
    <dbReference type="KEGG" id="kpin:30171976"/>
    <dbReference type="OrthoDB" id="70224at2759"/>
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        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12290">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="181"/>
            <end position="281"/>
        </location>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF50288.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC71532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1B9I4A4_9TREE</name>
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        <recommendedName>
            <fullName evidence="9">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_03663</name>
        <name evidence="11" type="ORF">I206_105431</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC71473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011563.1">
        <property type="nucleotide sequence ID" value="XM_019155409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I4A4"/>
    <dbReference type="STRING" id="1296096.A0A1B9I4A4"/>
    <dbReference type="GeneID" id="30172032"/>
    <dbReference type="KEGG" id="kpin:30172032"/>
    <dbReference type="OrthoDB" id="3257981at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051836">
        <property type="entry name" value="Kremen_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269">
        <property type="entry name" value="KREMEN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269:SF16">
        <property type="entry name" value="PROTEIN SLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628402" description="WSC domain-containing protein" evidence="8">
        <location>
            <begin position="20"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="9">
        <location>
            <begin position="44"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="9">
        <location>
            <begin position="185"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF50344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC71473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="756" mass="79626" checksum="F6AE5C1FE4702C5A" modified="2016-11-02" version="1">MFSQIAIIALAAMSTVVDAHPHNARSKGNVSRHVDKRAIATVSGWTYSGCYGDAWNRTLAASSKSDDNMTVQLCTSYCSGLGYTLAGLESKNQCFCDSQIRGTAGTKYADSDCSYQCKGDTSQACGGNWRLTVYNTTKSSSTSTSSSKTSTTLTSTSTSKAATSTSTSKATTSTTTSKAATTSSVATYYGCYADQSSPRLLSGANTESTSMTPSTCQTFCSGKGYSLAGVSYGKQCYCGNSIDSTKKQSSETGCSYACTGNSALKCGGFYYLNVYSSSGTIAITSSSAASTTSASSTSKSSSTTTSKASSTTSSSFSASTSATTTSAAAAAGSSAIGAPNPPSATGTKQLFAHHMVGNTYSYTQSTWADDISQASAAGIDGFALNYGSDSWQPSRIADAYAAAKADGSFKLFLSMDVTSLGCSSTNDAQNLVNTVATYANNTAQAKVGGKVLLSTFAGENCKFGQGSYQDAWNYFDTLLAAKSINVYFVPAVFADISTFSSSTWMDGEFNWNSGWPMGGSPLGTYSDTSYMSALGSSKGYMAAVSPAFFTYYSPSSYNKNWIYRSDDWLLARRMEQMISQRNLFDLAEIISWNDYGESHYIGPIRADQPNSQGWTNGMPHTAWLEVIKYYAPAFKTGSYPSANDQLVLWSRPHPKDAVPTSPSMARPTGADNTDDLLYVWVVLKSAATVTASSGNNTVSWNLGAGVNKVSVKSAAGSIGAKIIRNGATVKSYDSTGSFTYTNTPTDYNFNYFVASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I4D0</accession>
    <name>A0A1B9I4D0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_03706</name>
        <name evidence="3" type="ORF">I206_105387</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011604.1">
        <property type="nucleotide sequence ID" value="XM_019155450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I4D0"/>
    <dbReference type="GeneID" id="30172075"/>
    <dbReference type="KEGG" id="kpin:30172075"/>
    <dbReference type="OrthoDB" id="10532604at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628319" evidence="1">
        <location>
            <begin position="24"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF50385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC71431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="167" mass="18628" checksum="9272545FCFEA9100" modified="2016-11-02" version="1">MFSVKSITQLGVLVGMLGNQVLADSVNNLDMHAKYNITPAEHTRFVDIKTNDILASYPDAYAFDVLGDEGTGSKTFKWVYVDKNDDTKEEWSIELTAYCEGFWPETDVAVITLSLDRPWATLQASEITNSWFQSDKTTYKCNVPLCGDAPAFGVPAYSYVRTITSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I4Y4</accession>
    <name>A0A1B9I4Y4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Casein kinase II subunit beta</fullName>
            <shortName evidence="3">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_03913</name>
        <name evidence="6" type="ORF">I206_105178</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3">Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011807.1">
        <property type="nucleotide sequence ID" value="XM_019155653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I4Y4"/>
    <dbReference type="STRING" id="1296096.A0A1B9I4Y4"/>
    <dbReference type="GeneID" id="30172282"/>
    <dbReference type="KEGG" id="kpin:30172282"/>
    <dbReference type="OrthoDB" id="2275560at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1820.10:FF:000005">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000001">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01101">
        <property type="entry name" value="CK2_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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            <end position="223"/>
        </location>
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        <location>
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            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00045899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF50588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC71225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="348" mass="38241" checksum="07B3786996B3484E" modified="2016-11-02" version="1">MASSAPPVEMDPDELEEEAFDSSSQASSTATSTLTWINWYTSLPGHDYFCDVHEDFIEDDFNLTGLQAMVPFFKEALEMVLDVEPEEDSNKIPDVSIVESSAELLYGLVHQRFILTKVGLSCMVEKYEAGHFGACPRVFCHATPVLPCGRADMPGIDTVKLYCPNCGDIYTPPSSKYASVDGAFFGTTFSPLFFQQYPELLSAPFFATGPAAAQSSSRTTPVDSSAPVGGGTFTNPNPHGGQKAALGRVYVPRIYGFKVSERARSGPRMKWLRERPERFDDLDKVDWKSRFIVEGQNTEGDDELMASIGKQSGQGKGKLFDDEDDIVEDDDESEEEEENAPTTIAVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I537</accession>
    <name>A0A1B9I537_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_02689</name>
        <name evidence="6" type="ORF">I206_102342</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="OCF50635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC68415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019154451.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="30171058"/>
    <dbReference type="KEGG" id="kpin:30171058"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF18">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="75"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="567"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
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        <location>
            <begin position="577"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF50635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC68415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="675" mass="76022" checksum="AFFCD89746837DDC" modified="2016-11-02" version="1">MSGYSEEDYKDFKSFSMSGESFNAPLKKRRITRACDRCHRGGTKCSPGPTPSICGPCASFGSECTFLRPVKRRGPAARSHSHDENHHYPSSGGTSAPDSPSTRDDHWVYHEIASHEQIEELVEAYYRIIYPIQAYFHWPTFVSAINKRLYRKSRSFYCLTMAVCALAAARLRDGAPKEYHLKHELVPSEAYFQAIFTSFPTDLSKARDFDYKRTKVLLSMLCIQYGDISKAILHIGDYCTLISIDGFSLESRWPKGLNTIEIEERRRLYWNAYQADIYLATTFGGMIRHRESQSTVLYPAEVLTDDEITPDGILPHAIPGRVSFIRGWNFVTNLYRIIEHALCQMRQRNQSYDGENQIAMLFSTKKVGAKKYDPGPEEILQTVENLYKDLPDCMRGMKEMTGNTFEDRYGFQAANILITLQIVKMVIAGMAEWSVEQRCAIAGELLDSLSALPADFIRACSAPMLHHMAGVGHLLASIIQSPISPSAYLKVRTILLRLADLLSSLESTIKSASVICIAAKLRDHVERIDEYMINATEATGWNFALNSNTDSDTLQTSAHSAYQSSEPLIYNPRPSEHNSSAQRSTQSNELINFPQIPNYPPLLPNSNIDELIQPSMQDESTTQTQLDQQLKLPNDLFSDWSFMFNEFGSQGDAFDFLSTGIPTNGDWQVPGVSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I551</accession>
    <name>A0A1B9I551_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">50S small subunit ribosomal protein L5e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_02712</name>
        <name evidence="9" type="ORF">I206_102365</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL18 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1296096.A0A1B9I551"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Ribosomal_L18"/>
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    <dbReference type="InterPro" id="IPR025607">
        <property type="entry name" value="Ribosomal_uL18_C_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL18"/>
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    <dbReference type="PANTHER" id="PTHR23410">
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    </dbReference>
    <dbReference type="Pfam" id="PF14204">
        <property type="entry name" value="Ribosomal_L18_c"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="237"/>
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        </location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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            <dbReference type="ARBA" id="ARBA00022980"/>
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            <dbReference type="ARBA" id="ARBA00023274"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Pfam" id="PF14204"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF50657.1"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="WWC68437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
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    </evidence>
    <sequence length="308" mass="34703" checksum="91C40396F187B284" modified="2016-11-02" version="1">MPFVKTQKNDAYFSRYQVKPRRRREGKTDYQARRGLVSQAKNKYASPKYRLVVRITNKQVICQIVYAKIQGDAVLVHASSKELPKFGIEHGLTNWTACYATGLLVARRALTKLGLADKYEGVAEPSGELELTEALGDDEPRPFKAYLDVGLRRTSTGARVFGAMKGASDGGIFIPHNEKRFPGYDPETKAIDAEVLQNYIIGGHVAEYMESLEEEDDERFKKQFSSYLAADVGSADIEEIYTEAYAKIREDPSFTPTEKDVAKWKSESKKYKAPKSTKEEKQSRIQAKIEAYKAGKVDAAEEDEEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I5P4</accession>
    <name>A0A1B9I5P4_9TREE</name>
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        <recommendedName>
            <fullName evidence="6">Mitochondrial adapter protein MCP1 transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_02837</name>
        <name evidence="4" type="ORF">I206_102486</name>
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    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
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            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF50781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012000.1">
        <property type="nucleotide sequence ID" value="XM_019154597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I5P4"/>
    <dbReference type="GeneID" id="30171206"/>
    <dbReference type="KEGG" id="kpin:30171206"/>
    <dbReference type="OrthoDB" id="10259513at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
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        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039960">
        <property type="entry name" value="MCP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38409">
        <property type="entry name" value="MDM10-COMPLEMENTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38409:SF1">
        <property type="entry name" value="MITOCHONDRIAL ADAPTER PROTEIN MCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="70"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
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            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF50781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC68557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="35330" checksum="9073950B5EDDA388" modified="2016-11-02" version="1">MSPPPPEIPLPHQLAKQNDDSDPTRSRFNLPSKGQFIKFLTLTQNTSAMVFTIFLIPHLASPLVASVAGLEGADKTMMISRDLYIPLEPIIIYIPIGIHITSSILRRLIIIFYPNPNEIKNWKKIKNKLPKQIHQIIAYPLIILIINHYLTHRLIPSFKKFPINSLSPSELNWEFIGYNLNNNLLSWLNYLILIGFTSWHSIIGSMKIISFLKGSSPLDKFEKQLIIKENNNNNNNKNEEEEIIEISTKSNSKNRKIPKKRQVSLNALVFVILGITTIGLYRVKKDTGIISPLMKIRYDAIFQFYWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1B9I5S3_9TREE</name>
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        <recommendedName>
            <fullName evidence="1">histidine--tRNA ligase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_02888</name>
        <name evidence="11" type="ORF">I206_102537</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>tRNA(His) + L-histidine + ATP = L-histidyl-tRNA(His) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="1"/>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF50831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012050.1">
        <property type="nucleotide sequence ID" value="XM_019154647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I5S3"/>
    <dbReference type="STRING" id="1296096.A0A1B9I5S3"/>
    <dbReference type="GeneID" id="30171257"/>
    <dbReference type="KEGG" id="kpin:30171257"/>
    <dbReference type="OrthoDB" id="1906957at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000012">
        <property type="entry name" value="Histidine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476:SF7">
        <property type="entry name" value="HISTIDINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476">
        <property type="entry name" value="HISTIDYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core" evidence="9">
        <location>
            <begin position="73"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon-binding" evidence="8">
        <location>
            <begin position="460"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="354"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="354"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF50831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC68607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="562" mass="62260" checksum="06124B9FBF679C7A" modified="2016-11-02" version="1">MSTNTIESINNEILLLQNKIKELKISKKDASLEVNSMKLLKEQLKVLTKQNQDSISSNNNNNNFTLKTPKGTIDHKPEAALLRKKIFSTLESIFLKHDASTIDTPVFELKEILAGKYGEDSKLIYDLSDQGGELCSLRYDLTVPFARYVAMNGITSMKRYHIGKVYRRDQPVMTKGRMREFYQCDIDIAGTCDPMVYDSEILKILCEALTALDIGQYTVKLNHRKILDGIFQLAGVPADKTRSISSAVDKLDKLPWADVKKEMTVEKGLDEKVADKIGQYVGLKGQGYEILEKLKSDPELMGIPLAKQGIDDMEILFRYLKVYKVLDKMSFDMSLARGLDYYTGIIYEAIHESSAPPSRSVNPPVPANSSGSSSSKPPKSSKNAVINEDGIDESTVGVGSIAAGGRYDNLVGMFAESAGKKMNEQVPCVGVSVGVERVYSIMESRRKASQEKIRGKETEVFVLGLGGVELEKRMEVATLLWDNGIKTSFSPKVNPKAPAQWKQADDDSIPYVLILAPKEYAEGKVRIKAQLGKDQAGAEDNKGEEVPLESVVAYLKEKLGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I608</accession>
    <name>A0A1B9I608_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_03004</name>
        <name evidence="6" type="ORF">I206_102651</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF50942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012161.1">
        <property type="nucleotide sequence ID" value="XM_019154758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I608"/>
    <dbReference type="STRING" id="1296096.A0A1B9I608"/>
    <dbReference type="GeneID" id="30171373"/>
    <dbReference type="KEGG" id="kpin:30171373"/>
    <dbReference type="OrthoDB" id="10248551at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000002">
        <property type="entry name" value="40S ribosomal protein S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018268">
        <property type="entry name" value="Ribosomal_uS10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005729">
        <property type="entry name" value="Ribosomal_uS10_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01046">
        <property type="entry name" value="uS10_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00361">
        <property type="entry name" value="RIBOSOMAL_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="4">
        <location>
            <begin position="23"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF50942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC68717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="120" mass="13441" checksum="C6CBC090927F8D3E" modified="2016-11-02" version="1">MSEFKDDLEKTGGASAAQIHKIRITLTSRNVKPLEKFSTDLINRAKDRDLKVKGPVRLPTKVLKHTTRKSPCGEGSKTWDRYEMRIHKRLIDLNSSADVVKQITSLTLEPGVEVEVTIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I6L5</accession>
    <name>A0A1B9I6L5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinase regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_03243</name>
        <name evidence="4" type="ORF">I206_102893</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF51177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012396.1">
        <property type="nucleotide sequence ID" value="XM_019154993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I6L5"/>
    <dbReference type="STRING" id="1296096.A0A1B9I6L5"/>
    <dbReference type="GeneID" id="30171612"/>
    <dbReference type="KEGG" id="kpin:30171612"/>
    <dbReference type="OrthoDB" id="8170117at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.30:FF:000001">
        <property type="entry name" value="MOB kinase activator 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF51177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC68957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="219" mass="25603" checksum="C57BC9DFE4EA2A19" modified="2016-11-02" version="1">MSTLFNLKGNQSRTFKPKKVPEGTKQWQLKQYAQQTLGSGNLRTAVQLPEGEDLQEWIAVHVVDFFNHVNMLYGTISEFCTPTECPIMNAGPKYEYFWEDGENYKKPTHLSAPAYVEALMTWTQSILDDEKHFPQQIGKRFPPTFINTAKTILRRLFRIYAHIYHSHFDQICALGIEAHLNTNYRHFLLFVDEFQLLSEKDLIPLEEFNKTILDETGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I6T8</accession>
    <name>A0A1B9I6T8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="4">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_03307</name>
        <name evidence="8" type="ORF">I206_102955</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="4"/>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF51240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC69019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012459.1">
        <property type="nucleotide sequence ID" value="XM_019155056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I6T8"/>
    <dbReference type="STRING" id="1296096.A0A1B9I6T8"/>
    <dbReference type="GeneID" id="30171676"/>
    <dbReference type="KEGG" id="kpin:30171676"/>
    <dbReference type="OrthoDB" id="3609at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000017">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF30">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="5">
        <location>
            <begin position="7"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="6">
        <location>
            <begin position="196"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCF51240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC69019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="333" mass="36025" checksum="C443A6850FD735C2" modified="2016-11-02" version="1">MSRESVLLFGLGGIGGIYACILQLSGKCDVHVVARSNYNAVKEKGFKLISPKFGNHDGLKFAGVWKSTEEAAASGTKFSYVLCANKALLDAKPSLSDHLRPIITPSLTSIVLLQNGVGAEEPLHQSFPDTTVISAVVWTGGKALPTSDGVEQFNREGLTIGVDYRKNGNKQEEDSKLEKLVEWLKAGKGDCTVTEDIQSERWVKVIWNCCWNSLTTATRLKTGPFFESSSQALPLCYTVMREVEAVAKAKGLKIEDGTVDKLIKQCTDVPYPGLPSSMMADNNAGRPMEVEVILGTPVREGQRLGVPVPTLTAIYTIVKALDYGNQNSEAAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I7B5</accession>
    <name>A0A1B9I7B5_9TREE</name>
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        <recommendedName>
            <fullName evidence="5">Conidiation-specific protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_02146</name>
        <name evidence="3" type="ORF">I206_104612</name>
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    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC70661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="kpin:30170515"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="UPF0654_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36576">
        <property type="entry name" value="UPF0654 PROTEIN C11D3.01C-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR36576:SF1">
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    </dbReference>
    <dbReference type="Pfam" id="PF10346">
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF51432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC70661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="90" mass="9530" checksum="217710850A8A6FA5" modified="2016-11-02" version="1">MSAKQVAGGHKAAINNDDVPEESKEHSKQVVDEIEGSGETEVESAAEDRPKNDGNVIGGHKATLKNPNVGEEAKEHSRQVLSENGVEVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I7W7</accession>
    <name>A0A1B9I7W7_9TREE</name>
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            <fullName evidence="7">Terpene cyclase/mutase family member</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_02301</name>
        <name evidence="11" type="ORF">I206_104763</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the terpene cyclase/mutase family.</text>
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    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1296096.A0A1B9I7W7"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000002">
        <property type="entry name" value="Terpene cyclase/mutase family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000003">
        <property type="entry name" value="Terpene cyclase/mutase family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SQ_cyclase_C"/>
    </dbReference>
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        <property type="entry name" value="SQ_cyclase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018333">
        <property type="entry name" value="Squalene_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002365">
        <property type="entry name" value="Terpene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01787">
        <property type="entry name" value="squalene_cyclas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764:SF20">
        <property type="entry name" value="LANOSTEROL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764">
        <property type="entry name" value="TERPENE CYCLASE/MUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13243">
        <property type="entry name" value="SQHop_cyclase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13249">
        <property type="entry name" value="SQHop_cyclase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Prenyltransferase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01074">
        <property type="entry name" value="TERPENE_SYNTHASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0752">Steroid biosynthesis</keyword>
    <feature type="domain" description="Squalene cyclase N-terminal" evidence="9">
        <location>
            <begin position="77"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene cyclase C-terminal" evidence="8">
        <location>
            <begin position="382"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009755"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU362003"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF13243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13249"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF51586.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC70811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="722" mass="82696" checksum="071BDEB75A0E72B6" modified="2016-11-02" version="1">MEFQFPQTDLTGWRLKVGEDSHGQQKWVYLRDEQQRKEWPQNVTEKYWIGLRTESPELPKVNTPLESARNGFRFYKQLQSHDGHFSTEYGGPLFLLPGLIIALNVCGQKLLKEQEIEISRYLLNKRRPEGGWGLHTAAPPTVFGTVMNYVALRILGMGPDEGPMTEIRALIHKQGGATGIPSWGKVWLSVLGAYEWDGVGSIPPELWLLPDWLPFSPWRWWIHVRQTFTPMSYLYGTRFVGPFTPLVFALRQEIYTQPYESINWSAQRSNISPLDIYSPHHPVLDFAHGFLAYYEACPDIPCISSSFPLRKLAIKRAYEMLRYEDENTGYQTIGPVSKAFNMVCRYAKEGPDSKAFKAHLSRIDDFLWLGKDGLMMMGTNGSQLWDLAFMAQALSETGLAEEEEFKESTIGMLDWLDKAQIRDNPKWYHESYRHRTKGAWAFSTPEQSYVVSDCISEGLKAVMAIQALPYAPKAVSLERMRDAVDTILSMQNPSGGFASYELMRGSTRMECLNAAEVFGNIMVDYMYPECTTSALSALKSFSKLDPNYRQEDIQRTINKAIEYIHDEQKPDGSWYGSWGICFTYATMFALESLSISGETCANSERVRRACNFLVDRQMKDGGWGETYMSCVTMKYAQHEKSQVVQTAWAVLALIYANYDDKSVIERACRLMMGRQKPDGRWEQEDTEGIFNKNCAIDYPAFKFIFCIWALGRADKYLNGERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I8E5</accession>
    <name>A0A1B9I8E5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SH3 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_02554</name>
        <name evidence="4" type="ORF">I206_105015</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC71062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013057.1">
        <property type="nucleotide sequence ID" value="XM_019154317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I8E5"/>
    <dbReference type="STRING" id="1296096.A0A1B9I8E5"/>
    <dbReference type="GeneID" id="30170923"/>
    <dbReference type="KEGG" id="kpin:30170923"/>
    <dbReference type="OrthoDB" id="443981at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11525">
        <property type="entry name" value="SYLF_SH3YL1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033643">
        <property type="entry name" value="SYLF_SH3YL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF7">
        <property type="entry name" value="YSC84 ACTIN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ysc84 actin-binding" evidence="2">
        <location>
            <begin position="115"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF51838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC71062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="299" mass="30037" checksum="10C60309708500CA" modified="2016-11-02" version="1">MQGKFNGFLGKAQAALKDGQTRAASGSSTLMQSFSLPGESQKAAKILKSFLANPETPHTALNSIFKAVLQRAKGLAVFTILKAGFVFSGKAGSGLVIARLPDGSWSAPSCIATAGVGWGLQIGADMTEVVIVLNSDEAVKAFSRGGNVTVGGGISAAAGPIGTGGQVSASLANPAPMFSYSRSKGLFAGLTLDGTILVERKDANKDFYGSSISSTDILTGRVPAPEIAGEMYDVIEAAEGLDESGLPAEAYVPGQAGETLPIPNPSTGYPAPATAPPSTTAPATAPGAGNKTVFDSAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I942</accession>
    <name>A0A1B9I942_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Small nuclear ribonucleoprotein Sm D1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">snRNP core protein D1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I206_01278</name>
        <name evidence="14" type="ORF">I206_103721</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the snRNP core protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF51994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013213.1">
        <property type="nucleotide sequence ID" value="XM_019153052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I942"/>
    <dbReference type="STRING" id="1296096.A0A1B9I942"/>
    <dbReference type="GeneID" id="30169647"/>
    <dbReference type="KEGG" id="kpin:30169647"/>
    <dbReference type="OrthoDB" id="9626941at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097525">
        <property type="term" value="C:spliceosomal snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01724">
        <property type="entry name" value="Sm_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000016">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034102">
        <property type="entry name" value="Sm_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="90"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCF51994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WWC69778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="134" mass="14330" checksum="07F91F1D2ABA1880" modified="2016-11-02" version="1">MVLYRFLMKLNNETVTIELKNGSIVHGTITSVDPQMNTHLKSVKLTLKNQLPNQPPLSLDSIAIRGNNVRYYILPDSLPLDTLLVDDMPKAKRRKDGAPRGGAARGARGAPMRGGRGGGGGGGRGGPRGRGRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I959</accession>
    <name>A0A1B9I959_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homoserine kinase</fullName>
            <ecNumber evidence="3">2.7.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I206_02668</name>
        <name evidence="15" type="ORF">I206_105126</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-homoserine + ATP = O-phospho-L-homoserine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13986"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GHMP kinase family. Homoserine kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="3"/>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC71173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013170.1">
        <property type="nucleotide sequence ID" value="XM_019154430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I959"/>
    <dbReference type="STRING" id="1296096.A0A1B9I959"/>
    <dbReference type="GeneID" id="30171037"/>
    <dbReference type="KEGG" id="kpin:30171037"/>
    <dbReference type="OrthoDB" id="195231at2759"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004413">
        <property type="term" value="F:homoserine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00384">
        <property type="entry name" value="Homoser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000870">
        <property type="entry name" value="Homoserine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00191">
        <property type="entry name" value="thrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861:SF1">
        <property type="entry name" value="HOMOSERINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861">
        <property type="entry name" value="HOMOSERINE/4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000676">
        <property type="entry name" value="Homoser_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00958">
        <property type="entry name" value="HOMSERKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="12">
        <location>
            <begin position="69"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="13">
        <location>
            <begin position="260"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCF51951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WWC71173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="357" mass="38390" checksum="33DD6261BA4D7722" modified="2016-11-02" version="1">MSSSKIYKINVPCTSANIGPGFDVCGIALSKSLSLKVTIPQKPTEEGVLPKIIYTGLDSDNVPLSPYKNLLTRVALYVLRSHGIQNFPSQVIIEANNEIPFGRGLGSSGAAVIAGVLLGNLLGNLNLNKSRLLDFALMVERHPDNVSAALMGGFIGSYLRELSPEDMSAASIPLAEVLPEYPIDAGPNWGKNPPLPPKGIGHFVRFGWAKEIKAIAVSPRFELATAKARGVLPDNYSKKDLIFNLQRLAVLTTALARSPPDPELIYDAMADKVHQPYRMTLIPGLPKILTELTPTSHPGLLGICLSGAGPTILALATHNFDSIAQDIEQIFKNEGVEVDWSVLDVDERGSTVEEIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I9E2</accession>
    <name>A0A1B9I9E2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_01372</name>
        <name evidence="3" type="ORF">I206_103626</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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    </evidence>
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</entry>
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    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">CBS 10737</strain>
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    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="8">CBS 10737</strain>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Similar to amino acid transporter"/>
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        <property type="entry name" value="Amino acid/polyamine transporter I"/>
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        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
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    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SOBREMESA, ISOFORM B"/>
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    </dbReference>
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        <property type="entry name" value="AA_permease_2"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
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        <name evidence="16" type="ORF">I206_103008</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>S-(hydroxymethyl)glutathione + NAD(+) = S-formylglutathione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-(hydroxymethyl)glutathione + NADP(+) = S-formylglutathione + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-nitrosoglutathione + NADH + H(+) = S-(hydroxysulfenamide)glutathione + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:78371"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:145544"/>
            <dbReference type="ChEBI" id="CHEBI:229723"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a primary alcohol + NAD(+) = an aldehyde + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10736"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a secondary alcohol + NAD(+) = a ketone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17087"/>
            <dbReference type="ChEBI" id="CHEBI:35681"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.284" evidence="12"/>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013912.1">
        <property type="nucleotide sequence ID" value="XM_019153751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IB18"/>
    <dbReference type="STRING" id="1296096.A0A1B9IB18"/>
    <dbReference type="GeneID" id="30170355"/>
    <dbReference type="KEGG" id="kpin:30170355"/>
    <dbReference type="OrthoDB" id="417550at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051903">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08300">
        <property type="entry name" value="alcohol_DH_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000001">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014183">
        <property type="entry name" value="ADH_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02818">
        <property type="entry name" value="adh_III_F_hyde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880:SF12">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE CLASS-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="14">
        <location>
            <begin position="33"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="13">
        <location>
            <begin position="204"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCF52693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="WWC69072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="383" mass="40615" checksum="3AA3D99B2E943C64" modified="2016-11-02" version="1">MSTEGKTITCKAAIAWEAGKPLSIEDVEVAPPKDGEVRIKILYTGICHTDDYTLSGKDPEGAFPIILGHEGGGIVESIGAGVDNVKVGDHVVPLYTAECRECKFCKSGKTNLCGRVRATQGKGVMPDGTSRFKCKGKEILHFMGCSTFSQYTVVSKFSVVAVNEKAPLEKACLLGCGITTGYGAATKTPGIEDSNVAVFGIGCVGLSILQGAKAKNAKRIIAIDTNDKKEEWAKKFGATDFINPTKLPEGTSIVDKLVEETDGGLDFTFDATGNVNVMRSALEACHKGWGVCNVIGVAPAGAEIATRPFQLVTGRTWKGSAFGGVKGRTELPGIVDDYLAGTLWVDEFVTHHQPLEGINKGFDDMHAGDCIRCVVNMGFDDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IB67</accession>
    <name>A0A1B9IB67_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Velvet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_01930</name>
        <name evidence="8" type="ORF">I206_103066</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
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    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="135"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="218"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
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        </location>
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            <begin position="341"/>
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            <begin position="460"/>
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        <location>
            <begin position="1"/>
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    </feature>
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            <begin position="50"/>
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            <begin position="341"/>
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            <begin position="464"/>
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        <location>
            <begin position="477"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF53032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC67086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="529" mass="58276" checksum="D407AB31813C21B9" modified="2016-11-02" version="1">MGKQGNSKSAKGSITSRPAPYGKKPNVEVKFEGVPSTSSSSVKPTAQKSGKPEKPLKVGDKTKKVKQEVDAPQPTSKDKGKSKAIEQIAPSISTPSSKSTFVIIAGTYEKLLYGLEGSYPDPESGFPTLEPIFIFPAHLACVKAVAASKGGKWLATGSEDEFVKVWDLRRRKEVGSLSQHTGSITSLHFPTSSHLITTSEDSTLSLFRTSDWALLKTLKGHSGRVNHVDVHPTGRVALSVGKDNTLKMWDLMRGRGAASLPLGSEAEMVKFSQSGTHFAVLFPRKIQIYSLTLKLLHTLETKSRFNTLTFATLPDVGVGEQEYLCVGTEKGVVEVYTLEIGEQDVPEESDDEEDEEKEEREKEGSSAEVTRVGTLIGHTNRIKSISTLQFVVPAEDEEERPTILLTTVSSDGLINLYDLFWVENAHEIQGHGEANTRDPDASYDTKGSRLTCVYIADGQDLKNKNTPPKSSDLTAQLDDDEQESEEDEDVQDIYESGENDEEDEDEDDMQVEFEDEEEEEEEDEGEYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IBX8</accession>
    <name>A0A1B9IBX8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_00208</name>
        <name evidence="8" type="ORF">I206_101118</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF52907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC67211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014126.1">
        <property type="nucleotide sequence ID" value="XM_019151988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IBX8"/>
    <dbReference type="STRING" id="1296096.A0A1B9IBX8"/>
    <dbReference type="GeneID" id="30168577"/>
    <dbReference type="KEGG" id="kpin:30168577"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969:SF69">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969">
        <property type="entry name" value="RING ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="953"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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            <begin position="243"/>
            <end position="317"/>
        </location>
    </feature>
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        <location>
            <begin position="348"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="560"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="641"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="704"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
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        <location>
            <begin position="243"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="348"/>
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        </location>
    </feature>
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        <location>
            <begin position="385"/>
            <end position="396"/>
        </location>
    </feature>
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        <location>
            <begin position="465"/>
            <end position="480"/>
        </location>
    </feature>
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        <location>
            <begin position="494"/>
            <end position="518"/>
        </location>
    </feature>
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        <location>
            <begin position="578"/>
            <end position="593"/>
        </location>
    </feature>
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        <location>
            <begin position="667"/>
            <end position="684"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCF52907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC67211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1026" mass="112943" checksum="E1228B9663BCFF1D" modified="2016-11-02" version="1">MPPPPLVFHSTSPPHRYLSQTESDFIPSYAPGTRRLVQPIPIEPSHPTTEFQPYSVGSQGSIMSDISNSLRPSPPPLTATSSLPTPFTLRTPVDTTSATATARPIINSPVSPSADRTRLNESNNGLVRVKSFPHAGDLLGSPNEIVGNRTSNLGELESSLHHEDMDVDENEENRLAVAEMTSAGQVSDERDAIIQSEPSAPLGSLTRLLRDIGNPAPSHLTSQVPAYIQPMLNDRASVFRSRWSQPVASPSASTEPVHQNHALAQNPENGVPERQSSTDFNELGPLHGDDSPHTQLSRYDSTPYVQPANYHPSTSGGYLPGEWGEAFTSHPQPSNVVTNIANRSFIPPNTQTTTHDPAWSSSTTTDFRTLPSPIANTASGSPSAMERRLDTIEARLARGRAQRSPPTPPGLIHGHTYEGLRSRGVATRPYDVASRSRPSSQTVEDGSRRSPFARSSIRPSWLDQTAASATSSASSSSSATVPPPRPRPTASFGWETSNTLPASRMRSFSGTDQHTQLFTRAIRDDNGRPPTVFPGEGLQRDTRSRYLQARLNMFDNLRADPYRRSSPTPIRASGADAWSSSATQFTDDSSTASDRSERWTNHNLPTWLGDTSASRSLSAHSNPLRDDDIFNVEVGTPFIADIPDPTWGPEPTRPGNRRWMSFDEGTENTRIRESSRSREETSSHVEAIHDLGLLNRDVNEVIGRRLSQPRSRPASISRRLRDHQGPDWEDTSVPDTISGLYGLTPVAPTAATRRDRFNHSDVQPARSRTGNPFGATEDDREPRDPLATVLGRDRSNTTSPADELAAFIDRSIRARPALAVGGEDAELLFLDRLRNFNNLNARHGDLMPSRNGYDGLEGILDISSDSPFAHLDSLRRYNNFYSTPSLGNMKITKDMDWSEKLKIVQLVIRGVSKLPTTPRKKAAESTLKYIKYGEFDNGDNLKVVEGLQKDEYCSVCHDDYEVESEITITPCRHMYHRGCLDTWLNNPSTSSCPMCRRDLAALAYLTKMVPTKEVDEASPLWMAVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IC03</accession>
    <name>A0A1B9IC03_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_00255</name>
        <name evidence="2" type="ORF">I206_101071</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
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                <person name="Litvintseva A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
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                <person name="David-Palma M."/>
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                <person name="Mohammad A.W."/>
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                <person name="Yurkov A.M."/>
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                <person name="Litvintseva A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC66897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014441.1">
        <property type="nucleotide sequence ID" value="XM_019152303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IC70"/>
    <dbReference type="GeneID" id="30168892"/>
    <dbReference type="KEGG" id="kpin:30168892"/>
    <dbReference type="OrthoDB" id="5396at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861:SF11">
        <property type="entry name" value="CYCLASE"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF53222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC66897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="351" mass="39572" checksum="FF37692FCE9318B4" modified="2016-11-02" version="1">MSSTSDEDLTTSLLSLSHLTPSSHPSHPFSSWPSIPPNPIGRLILLTPEITKNAMNECIKTGKRFSLDWSIYPSGARMYGRSCGKHVIKRVDKGPSTKNDSKSINLDNNDLEEIEKNTFHPCFDDFIEINTQGSTQWDYFLHYSYPKSGLFYGGLTEDKIKNEDTGDFGISAIAKVGGVQTRGILLDIPLYLSKNNLPINSPLSNPPITKLNFELFLKVLNFFKIKPKIGDVLIIRTGFENSIIEFKNDIKINSWWGIEQSSEFIKWIWENGIVAVGTDNPTFENWPVSPNELQLHPVLLSGMGIMICELLRLDEISKQCEELNRWEFFFSSTPLMIEHGIASPPNAVAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9ICM8</accession>
    <name>A0A1B9ICM8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nuclear protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_00401</name>
        <name evidence="3" type="ORF">I206_100925</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014319.1">
        <property type="nucleotide sequence ID" value="XM_019152181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9ICM8"/>
    <dbReference type="STRING" id="1296096.A0A1B9ICM8"/>
    <dbReference type="GeneID" id="30168770"/>
    <dbReference type="KEGG" id="kpin:30168770"/>
    <dbReference type="OrthoDB" id="2506647at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF140">
        <property type="entry name" value="PEBP-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628595" evidence="1">
        <location>
            <begin position="18"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF53100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC67018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="307" mass="30013" checksum="D0884D5A7D102F42" modified="2016-11-02" version="1">MFALIPALALLALSASAQNSSSTVTTTDIEGLEANFKQAQLVPQLISDFEPEALLSVSFSGQAISIGDKLDKDAVASSPDLTVSPAPDQNLDAGALYTVLMADANAVGTDQNTTEQTRHWLVNGVSLSGDAAPYTVNYTGATTITDYAGPGPFEGTGSHRYVIAVYEQGSDFAAPANLSTPGVALGTWFLSSYVTEAKLGDLLTANYFQVENGQATSTAEATTSVDSATLAAAASTTGASASASSGAASATSGKASGSSGASATSAAASASGSSGAGAASGAGKTGVAVGMLVGAVGVVGAVIGAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9ICS9</accession>
    <name>A0A1B9ICS9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">60S ribosomal export protein NMD3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_00725</name>
        <name evidence="13" type="ORF">I206_100600</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NMD3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014641.1">
        <property type="nucleotide sequence ID" value="XM_019152503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9ICS9"/>
    <dbReference type="STRING" id="1296096.A0A1B9ICS9"/>
    <dbReference type="GeneID" id="30169094"/>
    <dbReference type="KEGG" id="kpin:30169094"/>
    <dbReference type="OrthoDB" id="203821at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048899">
        <property type="entry name" value="NMD_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048898">
        <property type="entry name" value="OB_NMD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746:SF2">
        <property type="entry name" value="60S RIBOSOMAL EXPORT PROTEIN NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21193">
        <property type="entry name" value="NMD_SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21192">
        <property type="entry name" value="OB_NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nmd3 N-terminal" evidence="9">
        <location>
            <begin position="19"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 SH3" evidence="11">
        <location>
            <begin position="252"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 OB-fold" evidence="10">
        <location>
            <begin position="316"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="486"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="490"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="528"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="562"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCF53422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC66696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="572" mass="63900" checksum="4676BB61B62E3D3C" modified="2016-11-02" version="1">MVAMDYEPDAAGQESYILCADCGTVISSANGAGLCVGCLRNTVDITEGIPKEATLNFCRGCERFLSPPQTWVTAQPESRELLAICLKKIARPLMKVRLIDASFIWTEPHSRRIKIKVTIQKEVLANTVLQQTFELLLVVHTGQCPQCTRLAAKNTWKASVQVRQKVTHKRTFLWLEQLILKHNAHKDTININEKRDGLDFFYSERNNAIKMVEFLAGVVPVRSKASEQLISSDTHSNTSNYKFTYSVEIVPVCKDDLVCLPRNQARAWGNISPLTICSRVGNTVHLLDPMTLQQTDVTAPVYWRQPFDSLATVTDLVEFIVLDVEPSGPVRGKYVLADAQVTRSSSSNNNTDDDGMGDDGIFHTRTHLGGILQPGDTVLGYHLTNANFNNDAFDSFDQDRIPDVILVKKTYPNRRKKSKPRNWKLRSIAKEAEDVAEGGNTLGRGALGRKGGVDQRNVERDYELFLRDLEEDKEMRAAVNLYKANQEAKEADDEDDDVGMGETTKKSGSGMKGGKRRTGVNGGTGEMQVDEDMGEGTDADDEEEEDFPEIDINELLEHFEEMDMEDATEEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IDF8</accession>
    <name>A0A1B9IDF8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_01035</name>
        <name evidence="6" type="ORF">I206_100290</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014947.1">
        <property type="nucleotide sequence ID" value="XM_019152809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IDF8"/>
    <dbReference type="STRING" id="1296096.A0A1B9IDF8"/>
    <dbReference type="GeneID" id="30169404"/>
    <dbReference type="KEGG" id="kpin:30169404"/>
    <dbReference type="OrthoDB" id="546893at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050375">
        <property type="entry name" value="MFS_TsgA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702">
        <property type="entry name" value="L-FUCOSE-PROTON SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702:SF3">
        <property type="entry name" value="PROTEIN TSGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="379"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="28"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF53728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC66389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="486" mass="52374" checksum="9093941204915EFB" modified="2016-11-02" version="1">MAGGAVVSGGSGGNPLRQGFIRREYLWAFILVTSLFFLWGFAYGLLDVLNKHFQNVLGITKLQSTGLQVAYFGIGYFAFSPVAGEVLKRRGYKTTIIMGLCLYSLGAILFWPVAKFSVNTKNPHAIFGGFVICTAVIACGLATLEVSANSYVSVMPPHNVANFRLQFSQSFNGVASFTGPLIASKYFFSEANKNNLSNVQWVYLAVSGMGVMVALAFLFTKLPEVSEEALQAEAEALAEVHGADTQADKPFYKQYRAITGFVAQFLYVGAQVTIGSFFLNYTYENAKIADSRGSQLLSYGLIIFTVGRFVGTALLSVIAAPVLLGVYAIACALLSILIGSLHGMSGVVCLMLVMFFESIMYPCIFVLGTSGLGRHTRRAAALLVMGVSGGAVFPPIQGAIADKFSTRTSYYLVVPCFVYIALWAAYVWNKDGRRFGVPATSDVEREVEAAAGGAVPPAAVGALGYTPKVEEERYESKDVIENIEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IDH0</accession>
    <name>A0A1B9IDH0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dephospho-CoA kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_00868</name>
        <name evidence="6" type="ORF">I206_100461</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014782.1">
        <property type="nucleotide sequence ID" value="XM_019152644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IDH0"/>
    <dbReference type="STRING" id="1296096.A0A1B9IDH0"/>
    <dbReference type="GeneID" id="30169237"/>
    <dbReference type="KEGG" id="kpin:30169237"/>
    <dbReference type="OrthoDB" id="247245at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02022">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00152">
        <property type="entry name" value="dephospho-CoA kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF53563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC66558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="298" mass="34575" checksum="4D775F13A684DFE0" modified="2016-11-02" version="1">MLIVGLTGGIASGKSTVSKIFNEKYNIPIIDADLISRQVIEPDTKGYKLILKHFGKFKILNNDSKKTINRIKLGEIIFNNNEKRNLLNSLLHPLIKKEIFKKVLFYWLIKGEWCIILDIPLLIESGIWKFVGEIIIVYVNEKLQLSRLLSRNSLTLSEEQAKSRINSQMSLKLKLNYSTFIIDNSGSINDLNLQIEKFILRLKKSQGFGFKNSFINGWWYKLCWILPPIGLISGLLVLFKRWLKYSSFFSNKSKKQRRRGRGEIDNSYNQENIELREINQNSNRRRTESSISGNSILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IDU1</accession>
    <name>A0A1B9IDU1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I206_01106</name>
        <name evidence="15" type="ORF">I206_100219</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the RBR family. RNF14 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="3"/>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019015018.1">
        <property type="nucleotide sequence ID" value="XM_019152880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IDU1"/>
    <dbReference type="STRING" id="1296096.A0A1B9IDU1"/>
    <dbReference type="GeneID" id="30169475"/>
    <dbReference type="KEGG" id="kpin:30169475"/>
    <dbReference type="OrthoDB" id="1431934at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20354">
        <property type="entry name" value="Rcat_RBR_RNF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23820">
        <property type="entry name" value="RWD_RNF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000416">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047548">
        <property type="entry name" value="Rcat_RBR_RNF14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="201"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="205"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCF53799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WWC66318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="545" mass="60952" checksum="35C60A1C9D5F5A13" modified="2016-11-02" version="1">MSDITIDDVAVECSSMQEDEITVLESIYPSLITVHENPDDKPGRLLSLTIPIAFATPHEIHLDTISGPSASLQLSHLPPLVLRVLLPSVYPLEEAPRPIHLRAPIPGGEKAGNWLPKLKLRQIQNKLVEMWDEEKQLNDEGMGIIWRWWEWVGTGDFLTDLEMYNGSSLELSISPLLSPSTFHTMLKTYNASQIHSDFRQTAFSCSICLENRKGKSCVQMPGCGCVFCTPCLSSCWSLAITEGSLENVSCPSVSCTKQRALRERGAAMDNDVTADLVESVVGSSLKDRWEDVKEKRKAEIDPSYTICPRPSCQAAVPAPDVPVSITFDSRFTSKIIRLSEISSTATESTLSSEANTKTDSTIPTEDRWARHRSCPKCSYSFCLYCNATWHGPHTPCAFPQTSLIVSEYLGYPEGSEGRSRMEMKRGKANLERMVAKYFEDEANKSWLESKTRPCSGCGVRVEKSHGCNHMTCGRCNSHFCYRCGDPIKPTDPYKHFNTPGKSCYQKLFDQEEIDRFQREAAGGEVVGGEGGADEDWREFRGIWEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IEJ0</accession>
    <name>A0A1B9IEJ0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CCT-theta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_01158</name>
        <name evidence="10" type="ORF">I206_100169</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019015070.1">
        <property type="nucleotide sequence ID" value="XM_019152932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IEJ0"/>
    <dbReference type="STRING" id="1296096.A0A1B9IEJ0"/>
    <dbReference type="GeneID" id="30169527"/>
    <dbReference type="KEGG" id="kpin:30169527"/>
    <dbReference type="OrthoDB" id="1748577at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03341">
        <property type="entry name" value="TCP1_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000008">
        <property type="entry name" value="T-complex protein 1 subunit theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012721">
        <property type="entry name" value="Chap_CCT_theta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02346">
        <property type="entry name" value="chap_CCT_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCF53851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC66268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="548" mass="58544" checksum="20AE334D57B5789D" modified="2016-11-02" version="1">MSLKVPKAGGPDLFKAGYKHMSGLEEAVLRNIAAVGELSEIVRTSFGPNGRNKLIINHLGRLFVTSDAATIIREIEVAHPAAKLLVMASTAQEAEMGDATNLVLIFAGELLKRSEHLLTMGLHPSDVILGYEMALAKGREELETLISSTIPSSPLPTAETLSKAVATSLASKQPGCEDFLSDLVAEASLAVMPKNPKDFNVDSVRVVKVLGGGLEASRVVRGMVFGREPEGIVKNATKAKVAVYTCGLDISQTETKGTVLLKKADDLLNFSRGEEKQLEGYFKEIADSGVKLIIAGSGIGDLALHYLNRLNIAVIKVLSKFDLRRLCRVVGATPLARLGAPTPEEAGMVDVFETVEIGGDRVTVLRQEEGEKTRTATIVLRGATANYLDDLERSLDDGINTVRILLRDGRQVPGAGSSEIEVARRVAEYGGKTSGLAQHSIKRWAESLEVVPRTLAENAGLNAEDVVSSLYKSHTEGQSDAGVDIESETDGVVESTKAKGILDPFAAKDWAIKLATDAAISVLRVDSIIVAKQAGLAPPKQQGHWDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IF41</accession>
    <name>A0A1B9IF41_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_01227</name>
        <name evidence="2" type="ORF">I206_100101</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019015139.1">
        <property type="nucleotide sequence ID" value="XM_019153001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IF41"/>
    <dbReference type="GeneID" id="30169596"/>
    <dbReference type="KEGG" id="kpin:30169596"/>
    <dbReference type="OrthoDB" id="2561307at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCF53920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC66200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="141" mass="15894" checksum="8D7A4CA816CFF7BC" modified="2016-11-02" version="1">MTVTESYFQGAIDLILGGDLPGFLEQYVEDNVEWMVINAEVKSSPFSGLYHSKQEYFATAAPLFGAFNGPTKFELERSTLAGNLAFLELRGTAVGKKDGKTMVGYWVWILEFDDGEEKPKIKKIKEYFDSALSKEFIENNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8KYG2</accession>
    <name>A0AAJ8KYG2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_100126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058240.1">
        <property type="nucleotide sequence ID" value="XM_070202139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8KYG2"/>
    <dbReference type="GeneID" id="30169570"/>
    <dbReference type="KEGG" id="kpin:30169570"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="63"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC66225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="350" mass="38814" checksum="8F32A0297935414B" modified="2024-07-24" version="1">MSVSRTTNRRTPSSPYRQPSGSSLSSARPPGSSGSSSKPPGTGSSVSSQEELGLSAWLACSADQEARIGYVSESMQEILGYTPNDLIGKSTYLIFHPDEIPMLREIHYQALTDEKTACVAYFRALHKDGYYVECCCSYYTVYNMSLALYTRAVDGQRTLQQALTAREVIEVSPSSQGKFAIKRWPSSSKAPLQSSPHSTSISLSPPPMDYPWPAPHKPSSRTFFILDRFTDTSRVMYVSNDVIINGSRLRNQSFYSAIRPSDRSHVRKYIESAKQSSPIMFNEKRSGGHGYTTFHISDLPPRGETWPQGTDESEKSMPGQEFILVEGIFTASSDGLACVISRVVPDKRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8KYV0</accession>
    <name>A0AAJ8KYV0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Amidophosphoribosyltransferase</fullName>
            <shortName evidence="8">ATase</shortName>
            <ecNumber evidence="3 8">2.4.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I206_100322</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H2O</text>
            <dbReference type="Rhea" id="RHEA:14905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="EC" id="2.4.2.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="3 8"/>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014916.2">
        <property type="nucleotide sequence ID" value="XM_019152778.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8KYV0"/>
    <dbReference type="GeneID" id="30169372"/>
    <dbReference type="KEGG" id="kpin:30169372"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11907">
        <property type="entry name" value="AMIDOPHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000485">
        <property type="entry name" value="Amd_phspho_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="12">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="423"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC66420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="507" mass="55636" checksum="E0441A6780DF56AE" modified="2024-07-24" version="1">MVRDVFDAPAVAGLKGWMGVGHVRYPTAGSSAHAEAQPFYVNSPYGIVFAHNGNIVNTPSLRQYLDVDAHRHINTDSDSELLLNILANNLQKTGKFRINEEDIFTAVGDLTRTCIGAYACVAMIAGFGLIVFRDPNGIRPAGIATRKGARGGLDYLVASESVVAQGLGFTEWEDVKAGEAIIITRNNISRRQVAQPQAFAPDIFEHVYFARPDSTIDGISVYRSRMKMGDLLAETVKKELVKANIEIDVVIPVPDTSRTAALNCAQALNIPYREGFVKNRYVGRTFIMPGQTQRRKNVRRKLNAMPEEFAGKTVMLVDDSIVRGTTSKEIVQMAKDVGAKRVIFASCAPPIRYSNVYGIDMPSPHELIAHGRTTEEIAEHIGADLVIYQTLEDLVESCRQFNPVIKQFDCSVFTGEYVTGGVDERYLEHIQRLRNDNAKAKKKQQTFEAVEATEGGCSGPMNGADSLISMHRSDSLMGLANHSPKLGATGMPSPNDTIGLHNSWYGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8KZM2</accession>
    <name>A0AAJ8KZM2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dolichol-phosphate mannosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_101285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058459.1">
        <property type="nucleotide sequence ID" value="XM_070202358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8KZM2"/>
    <dbReference type="GeneID" id="30168407"/>
    <dbReference type="KEGG" id="kpin:30168407"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013744">
        <property type="entry name" value="SidJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591:SF1">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08538">
        <property type="entry name" value="DUF1749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WWC67377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="32908" checksum="1251F909B94B464B" modified="2024-07-24" version="1">MSLSGTLTTFEAGPWKFPLFTSGDLNSDKAVAFIGGLTNGLGAVPYTYPLSEAVGKAGWRFIQFHWSSAYGGYGTGSLKRDNSEIEALVKHLRSTGVKTLVLAGHSTGSQNVMQYLSNPLYQSSTPESDGLRIEGGIMQAPASDREFLDLLGLKDWFDVLPLAEQMIKDGKGEELMPKEFCESAGSDGVPLPITAYRVWSLVGVGGDDDFFSDDIPAEPKEGCKHSLSSSFGKLSAPALVLYSEEDEKYQKGDVHVKLKRWEEASNGKLHLHFLKNASHDVVQPEAQKVLSELVVEWLKQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8KZQ1</accession>
    <name>A0AAJ8KZQ1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">2,3-bisphosphoglycerate-independent phosphoglycerate mutase</fullName>
            <ecNumber evidence="6">5.4.2.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cofactor-independent phosphoglycerate mutase homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">I206_100760</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BPG-independent phosphoglycerate mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.12" evidence="6"/>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014485.2">
        <property type="nucleotide sequence ID" value="XM_019152347.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8KZQ1"/>
    <dbReference type="GeneID" id="30168936"/>
    <dbReference type="KEGG" id="kpin:30168936"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006007">
        <property type="term" value="P:glucose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16010">
        <property type="entry name" value="iPGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1450.10:FF:000001">
        <property type="entry name" value="2,3-bisphosphoglycerate-independent phosphoglycerate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000001">
        <property type="entry name" value="2,3-bisphosphoglycerate-independent phosphoglycerate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1450.10">
        <property type="entry name" value="BPG-independent phosphoglycerate mutase, domain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01038">
        <property type="entry name" value="GpmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011258">
        <property type="entry name" value="BPG-indep_PGM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036646">
        <property type="entry name" value="PGAM_B_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005995">
        <property type="entry name" value="Pgm_bpd_ind"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01307">
        <property type="entry name" value="pgm_bpd_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637">
        <property type="entry name" value="2,3-BISPHOSPHOGLYCERATE-INDEPENDENT PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637:SF0">
        <property type="entry name" value="2,3-BISPHOSPHOGLYCERATE-INDEPENDENT PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06415">
        <property type="entry name" value="iPGM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001492">
        <property type="entry name" value="IPGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64158">
        <property type="entry name" value="2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9 15" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="16">
        <location>
            <begin position="27"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="BPG-independent PGAM N-terminal" evidence="17">
        <location>
            <begin position="105"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="13">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="176"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="282"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="481"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00083354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF06415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="WWC66853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="534" mass="58730" checksum="F3179E0947A26492" modified="2024-07-24" version="1">MATRSAASPEIAQDAKKQKTDSVQVKKKVCLIVHDGWGLSDNEKGNAIFHGDTTHMDAIRDKHNFVELEAHGLAVGLKEGLMGNSEVGHLNIGAGRIVWQDIVKIDQTIKKDEFQNQPAIVQAMEHAKSNSGRLHLAGLISDGGVHSHIQHLFALLKVAKKHEIPHVYIHFFGDGRDTAPKSATKYIGQLQDYIKEIGIGEISTVIGRYYAMDRDKRWDRIKIAIEGLVEGKGDKSTQEILIADVEKGYENGITDEFIKPIISGSEDSRIKKGDTLFLFNYRSDRMREIASVLGLPDKPMEVNVPEDLNITTMSRYNAEFPFNIAFPPQGMTNVLAEWLGKQGVKQSHIAETEKYAHVTFFFNGGVEKQFLNEQREMIPSPKVATYDKQPEMSVQGVADKVAEVVKSDEFEFVMCNFAPPDMVGHTGDYEAAVKAITATDKAVKTVYDACEEAGYVLCVTADHGNAEQMLDPVTGNPHTAHTTNHVPFIVTGDKGALEVSSEPGALADVAPTILAILGLPQPEEMTGRSLLSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8KZW1</accession>
    <name>A0AAJ8KZW1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_100688</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058354.1">
        <property type="nucleotide sequence ID" value="XM_070202253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8KZW1"/>
    <dbReference type="GeneID" id="30169006"/>
    <dbReference type="KEGG" id="kpin:30169006"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000025">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase CYP19-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="7"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="174"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="307"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="264"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="346"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="399"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="420"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC66783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="456" mass="52731" checksum="ABD0190EDB64AA02" modified="2024-07-24" version="1">MPNPRTFFDFSVGDKSLGRVVFELYKDVVPKTVENFRALCTGEKGISKISNIPLHYKGCPIHRVIDGFMIQGGDFTKRNGSGGESIYEGPFEDERLEGEGTEVDKKGLLVMANRGPNTNGSQFFITLAPSPHLTGKHVVFGKVIFGLEHIEAIGKLSTDDRDRPLTPVVISHCGELELKRPPPKQIRSPSVSSSRSRSVSPDRRRRKSKSKSRRDDSEDEVSDDSLEKERRKSKKKKDRKDRDRKDRDRKKEKKPREETEEELDMRLEREEKERLEKERLTRLEEMKKQIELERQKIKDEGGVVYKGRGSMRYLDPETTHRSMPRNFDSRATDSRPRAPRGPPPHLSDRISNPRDRRDDRGFDRGDRRENTQRDRLDRDMDKWQHDRSQAQSIGDRERAKFRRGRSRSRSRSPVNNGNERSISPRPSSVIPTRMRSRSKSIGARSDNSDMVLDLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L1I7</accession>
    <name>A0AAJ8L1I7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I206_101556</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058514.1">
        <property type="nucleotide sequence ID" value="XM_070202413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L1I7"/>
    <dbReference type="GeneID" id="30174841"/>
    <dbReference type="KEGG" id="kpin:30174841"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13279">
        <property type="entry name" value="PH_Cla4_Ste20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000139">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000705">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PH" evidence="12">
        <location>
            <begin position="69"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="14">
        <location>
            <begin position="168"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="390"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="228"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="299"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WWC67646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="660" mass="72703" checksum="EFEE93115DE5EFFB" modified="2024-07-24" version="1">MSYNLASLTPSRPAPAPPARGQTPSASDPHANSSQMRSNFSSTSYASSFPSINPTSNLSVTRPNAGANQTVRSGYASVKEEGLRAFMWSKRWLVLGGTELSMYKNEQSSTPVFVLPLSDIHDVQRVDMKPFCIELETKEKLLYFTFRSDDEVYAWMDDIYNRSPLMGVSGPTNFVHQVHVGFDPISGGFTGLPPQWSKLLTSSAITREEAARHPEAVLDVLQFYTQQQMGQGDYQRPSAPSLPDSSRTSSTAATRFEGAGLAGQPPPLQPQRLRDPTISNNHTRSISKVPPQAAIAGPRETRPLVAERKAPPPPRPAGPSQPLDTSVPAKVQVKKDLVQATSVLAQPASASTHAQVSTARTERRISTMNEAQIMDKLRSVVSSDDPAQLYSKIKKVGQGASGMVFVAKTLASGKKVAIKQMDLQQQPRKELIVNEIIVMKESQHPNVVNYLDAFLVRNSELWVVMEYMEGGALTDVIENNKLAEEQIAAICLETCRGLQHLHSRSIIHRDIKSDNLLMNAQGQVKITDFGFCAKLTEQKSKRATMVGTPYWMAPEVVKQKEYGAKVDIWSLGIMAIEMIENEPPYLDEEPLKALYLIATNGTPTLKSPEKLSQDLKHFLSVCLCVDVSFRATSSELLKHEFLQTACPVSDLAPLLRFKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L221</accession>
    <name>A0AAJ8L221_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Steroid 5-alpha reductase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_101624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008724.2">
        <property type="nucleotide sequence ID" value="XM_019158111.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L221"/>
    <dbReference type="GeneID" id="30174775"/>
    <dbReference type="KEGG" id="kpin:30174775"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF15">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE (DUF1295)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC67712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="40278" checksum="B8CB42CAFFBE8664" modified="2024-07-24" version="1">MSPHIIIDQYNLTISFLITLAWQMIGFAIAWTFKFDKVTDFTGGSNFFILALITLTTGDTYTARNIVASVLTMLWAARLAGFLLFRVLKTGSDTRFDDIRSHFFKFAGFWVGQIVWVWIVSLPVVILNSSAVSSTLRSGDPSFGKATDIIGIILFAIGLFWEAVGDIQKYMFKSSKPPKGQPCTKGLWYYSRHPPYFGEMTLHWGLWLLCLTPTINGGLPNSAKAAQYSAILSPIFTMILLLFASGLPTAEKPTAKKFFLMSYSSIKQNQLDNNNNNSSSISTRFSEPEPENEIWSNYKNYLKKTSIIIPFPPFLYLNLPEWLKSSLLLDLPFFKFDEQIDGKQALEEERKKRASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L2F2</accession>
    <name>A0AAJ8L2F2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_101794</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058557.1">
        <property type="nucleotide sequence ID" value="XM_070202456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L2F2"/>
    <dbReference type="GeneID" id="30174602"/>
    <dbReference type="KEGG" id="kpin:30174602"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WWC67877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="29166" checksum="77A478CA2C739F1C" modified="2024-07-24" version="1">MTQPIPASETKHLNQLNHPLIYPFENERKKKKKKKILELGSGIGYSSLNLLSKGFKLISTDIQPILNDVLKPNLIEGIKILNENEIKINIEEDLKFIELNWIKISNLYDNYIFEKNNLNNLIEIENFKKEFEFEYFKEINFIILSDTFYTIELIKPLWKTLILISIFSSNTSKNKKSNLPIIYISLERRDSILIDKALDEGKNLGFNLKQIHKLTLKKEIEKYWNNWKDEDWDDIEIWKCRWKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L345</accession>
    <name>A0AAJ8L345_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1479-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_102603</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
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    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <source>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
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                <person name="Imamovic A."/>
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                <person name="Shea T."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">CBS 10737</strain>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        </source>
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        <source>
            <dbReference type="EMBL" id="WWC69554.1"/>
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    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="27700" checksum="CC40F35BDB164084" modified="2024-07-24" version="1">MSTDKRVIIVTGASAGIGRSTSIHLSNIFPSSEHPEQLVLVLVGRRESELQKTADSLRNGTIAEIAAGDATSEEFVNALEATIKEKYGRLDLVFNNAGVNYKSDGQFEDQDMSLFRQVLDINIMGAVLFTKLAFNIMKSQSPQGGRIINNGSISATAPRPNNTSYTISKHAITGLTRSSSLDGRKYNITCSQIDIGNASTEMGSYVSAGSMQADGSIKKEPTMSVDNVAKTVGFIAGLGKDVDILSLEIIASGMPFIGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L460</accession>
    <name>A0AAJ8L460_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_102727</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">CBS 10737</strain>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">CBS 10737</strain>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="match status" value="3"/>
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        <property type="entry name" value="START-like_dom_sf"/>
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        <property type="entry name" value="START_lipid-bd_dom"/>
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        <property type="entry name" value="START_lipid_transfer"/>
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        <property type="entry name" value="PHOSPHATIDYLCHOLINE TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308:SF54">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1570"/>
            <end position="1590"/>
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        <location>
            <begin position="481"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="674"/>
            <end position="707"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1025"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1531"/>
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        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000259" key="3">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC68792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1639" mass="179209" checksum="018E2CFBB8E11CB6" modified="2024-07-24" version="1">MRLENLDDGSKLEAAWHEALATSLTYFRALLSSSSSSAWKPVSVLPLTASTTAKDTGKSTAKGSSLGKIDASQVVVHRRNGKSGEVYRAVVEVDCGSDVSIDTFRGCLVTPETRPVWDRMVEEAVTLDLLDAHTRVNRTNYRLGWPSSPRDAVTISKTLVDQHTLIDITTSLPRSKHEPAYLRPAPPHVRAHVALLAWCIQLPSNNFSDTLPEGKARITCFWSWNPKGAWAVGGGVPQHLPSLVVGLVDYVRDGSEKVPVLLGYGPDVAIGSVQYDTSRVTLSVGYAIVAAGGVNRETEDLRRQVEFGISSTQSWDVQISVRTQHGKDSPSASWSSFVGQAPNHLDGATAPKRLILRFAHAQLDPGEELVRVNVSIERTTSSSAGVRINGIPVGVEPMQAPIPRRPLLEDTASMTGISLRTIATAESQHSHEGSVDLRRAISQRSDAAHKSIASLIRRNYIYSRGVAIHQLNSIDKTLIVFRAEAVFVGVGIWDLFAVIASPGARLVWDKSHEDADLLEDVNELTDLWHIKSKAAWPISARDSVMLRTTYKSPSSVHLFGFSTDDTDLFPRIPAVTDPNVIRTQIDLQGWSVESLSPNTTQVTLLEQSDPRGWSNKSSIPQVMMSTLAGIGEFAIKHGAPPVATRLGGARVLSSRYDVEQETFKFEYEAAEARRSNSSSTHTSFPLPVAVKNPDPENGGSEASSLRSMNVSRPLSNIECEIRCDADQWSNSFAILIDPPQQSISALRRHRLSPSGGGLWLTIEHDPTVLENDKVAITVRRGTAQPGKTSVTVNGSKVKIDLEDLPDGEVQLLKKQKRGRPTRVPLDQPPALGTLRKKRSNLDLGTISAANSPDPNQSPIASSASTFTKYAMPLSKWYNVAAETTRAAIIPMATAKPATVSGSKPVDAAVKALSQLAKIHADRDGESTDPNSWQPVSDREGLRIEKKSVGHVSESFPVFRAGRIIEGFTAEDVSAAVSSLRKDERFDRPTTLQSFGHGITTSHMIAHTTFPFRGRSMLVATIVARMPDPPPPSPSQHGPHTPLSTIFHASSSSFDTEAIGLDWIKYNPTALPQGHIILEGWIIETIDPYSHEQYAIPSTRCMYVASVDYSGSMPLSVNNMLNSSLPRALLSIESVLKGSGSPSRARSPPMLVLAPEERSSPPWALEGIEESCVGVYQKIEDDHYSLTVTVQPPTPSSRDREREGTLSPPLRHNESKTSINTGRSTVIDLAEEIRKGRKDLLVLEVELGISSMKAGCQIDLKAVSLPIATHDPQSESTNLPLNLPNEYLDLPFRCSIISLAPNVLQSASLDPTSQSKHLLRVTLPTTGYDAPISDPLGGTAAPTPRPRWLLDLINDGAVIQLTLKPHSAPKEGEDKKKGYWYGLNEVLVEDEKRSKTFGLRDFNKSNLPQLVNRATQGSTSLGGPLAVAREYFKDEVKKGERLPEAGESDILRSTITLSEEGQGVILNTKDSQIIEPSSTTTNVPESHSRYSYNFWRYSRLPRFSNSAPATAEHSPVKTTTLRLPNPLGYNSEHIDQDSTKDSSSMTKEKNANIKISSPTLRNDNREIMKPVISFPGLIIACMICLLLGSLLRSILVEADFVIYQSINERSQGEHWRELKRLAEWGIGWNRDLIVAIARRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L478</accession>
    <name>A0AAJ8L478_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Indigoidine synthase A family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_102781</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058723.1">
        <property type="nucleotide sequence ID" value="XM_070202622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L478"/>
    <dbReference type="GeneID" id="30171505"/>
    <dbReference type="KEGG" id="kpin:30171505"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004730">
        <property type="term" value="F:pseudouridylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1790.10">
        <property type="entry name" value="Indigoidine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01876">
        <property type="entry name" value="PsiMP_glycosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022830">
        <property type="entry name" value="Indigdn_synthA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007342">
        <property type="entry name" value="PsuG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909:SF1">
        <property type="entry name" value="CARBOHYDRATE KINASE PFKB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909">
        <property type="entry name" value="ZGC:136858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04227">
        <property type="entry name" value="Indigoidine_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110581">
        <property type="entry name" value="Indigoidine synthase A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC68845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="808" mass="87241" checksum="5CF948F09EB65EE7" modified="2024-07-24" version="1">MSLISTLAPISRTSWSRIGHSGCLGRGRGRNQRNIYNLTRGKQVWGNRLILSEEVQHALETLKPIVALESAIITHGMPYPANLSTATSLESIIRSKGAIPATVALINGKIHVGLTESELLQLSDTDSKISKSAVKVSKRDLGPAISLKRSGGTTVAGTMYIAESLGIKVFVTGGIGGVHRGAENSMDISADLLELGRTPMAVFCAGAKSILDIPRTLEVLETQGVCVASYGEQQDFPAFYTPSSGCQSPWRVGDADAAARLIYTQLTLPTKLATLIGVPIPSEHAQSGAEVQKSVEQAVRESVQQGIDKRGKEVTPWLLKRVGELTGGKALGLNVNLIENNARIGAEVAVKLSELYRLEGESGEKGNALNYLYSPPTSHIARECTKDSLPIASIPTRSNLTPTKSNILLPPEVLVFGSAAIDLTSTSPLPLVPRTTTPGTVFVSPGGVGRNIAEAAQNLLPPFSVQLVSSFGINSTSNPNYHSSQKGKLLPSEVQGGGEEPDAFGKLLMLELAAAGLRTDGLIGKDGRSTAVCSLTLEENGDLVAGVADMGIVETIKSSKVEEIIQSRLPRLVVLDCNITEEVIRTILTVCQALNIPTMCDPTSLPKVPRLSSTLKSLLPSSPKDPRPLTHLSPNILELDDLYQKIVIDNSSEDFEMIQWEFINSLNLDSTWRNMIDNFTQKNERNWIKEQGIIPKMIKLLPFIQSFWLKISSQGLIHFEISNNINSFKENSISYKLEGIHKGKSLILTHYNSPQIEQNEIVSTTGAGDTLVGGLVAGLIKNEEQEHEWVMIALEKVKKSLQSRRAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L4C0</accession>
    <name>A0AAJ8L4C0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Peptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_104309</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059031.1">
        <property type="nucleotide sequence ID" value="XM_070202930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L4C0"/>
    <dbReference type="GeneID" id="30172483"/>
    <dbReference type="KEGG" id="kpin:30172483"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07489">
        <property type="entry name" value="Peptidases_S8_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010435">
        <property type="entry name" value="C5a/SBT2-like_Fn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034187">
        <property type="entry name" value="Peptidases_S8_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF66">
        <property type="entry name" value="SERIN ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06280">
        <property type="entry name" value="fn3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042462742" description="Peptidase" evidence="8">
        <location>
            <begin position="21"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="9">
        <location>
            <begin position="214"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="C5a peptidase/Subtilisin-like protease SBT2-like Fn3-like" evidence="10">
        <location>
            <begin position="658"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6 7">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6 7">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6 7">
        <location>
            <position position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC70359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1003" mass="106901" checksum="7466BA267E25DB57" modified="2024-07-24" version="1">MRNSNLFSLALALIGSNVDAFNLADVQKTTSGSVVPGRYIVEFDSNAHLSSSGLKRDESISTPHEAIYKQLKARDTSYTVHCEYTNNLFFGASITLDSDNDLANLLSTDGIIDFRQVHLLNLPSQPITAQSYQWPASTSFNSTASNSFSPSNATTSAQVTTTTSCSGKGKKQKCTTSTVTASSAPSASASAVNKGFSVLNQIGADTVQAGGNKGKGVKIAIIDSGVDYTREPLGGTYAQAGSKFVGGYDFVGDSYNGTNTPQADNDPFDNCYSHGTITAGLIGANPNLYGVTGVAPEASLYQYRVFGCNGATTDDIVLQAMQRAYDDGVDVINLSVGETSGWTESMLSVFASRLSSAGVVLSISAGNQGQVGAFYSYSPGAGLGVLNVGSNDNAFYPSQLASVSTGYGPIPYFNYKAFASGTYPLYAFTTDPSVAADGCTIPDGTPNLNGYVTLVRRGGCSLEQKAKNIYLQGGRQMFLINTANTVPLYQNFPLDFAMISYDDGNYLLSQINNHTSNTTVTFTFNPYQSPNTFTGNITSYFSEIGPTNDLYFAPSIVAPGTNMVVILPTNMANWSIVEGTSYSAPLVAGSAALYINAKGNNNVSPDKVKAALQSTSDYLRTSVSDQTIANVAVQGAGKVNIANAINPGLIVSPSEILLNDTNYFAGTQYITLTNPTDKIVKYKLSNLPAGTALAFQSGLNQSNDQPVPQVSSVASVRFSQSSITLLPRTTWVVLLQFTAPTGLDAKQFPIYSGFIEISGGANNVRVPYLGVASKMKDMPVLDPTPYYLGINTPTILDATGNVQSSSGQSYNFQNGSYPTVIYRLVGGTPLLLIDLIDSNANIGFTPNYNSKRSPVEGATLEGELNLMKKAYIESRKINSISNSNNWWQSTKTQSLISLYCQLTNFQGKGCSGYNNGKSNTFAKVPILGNLFESDYIPRSTDNIDGQGNDYSTFALKSGPLFSNGTTIPNGNYKFLMRALHITGDRTKESDYEAWVSAPFTIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L4K3</accession>
    <name>A0AAJ8L4K3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase M50B-like-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_102730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058718.1">
        <property type="nucleotide sequence ID" value="XM_070202617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L4K3"/>
    <dbReference type="GeneID" id="30171454"/>
    <dbReference type="KEGG" id="kpin:30171454"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049500">
        <property type="entry name" value="Peptidase_M50B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979">
        <property type="entry name" value="OS02G0221600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979:SF2">
        <property type="entry name" value="PEPTIDASE M50B-LIKE-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13398">
        <property type="entry name" value="Peptidase_M50B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC68795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="28795" checksum="9986F946451CA819" modified="2024-07-24" version="1">MSPLPLPIDDPTLHYIPRRAVVDALTPNPTQRVTLIVAACYVVAIGILPILEKIIYPFKLLTVGMHEMSHALAGVLTCASVEKITLDPQEGGSTRMRGGIPAITLPAGYLGSSFIGACLIAVGFDTNASKVACLILAFFWILTLWWARSSWIAWATIAVMAALIIITWLVAHSVALRFLILFIGVMSCLYAIWDIVDDTLARKVNTSDASEYANIIGCCGSRFWGAFWLVISCVFFAAGLLVGIAVFKDDWDTQAARADDFLGGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L6N0</accession>
    <name>A0AAJ8L6N0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Small nuclear ribonucleoprotein E</fullName>
            <shortName evidence="11">snRNP-E</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Sm protein E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I206_105127</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in pre-mRNA splicing. Binds and is required for the stability of snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site. Involved in cap modification.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC71174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059164.1">
        <property type="nucleotide sequence ID" value="XM_070203063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L6N0"/>
    <dbReference type="GeneID" id="30171038"/>
    <dbReference type="KEGG" id="kpin:30171038"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01718">
        <property type="entry name" value="Sm_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027078">
        <property type="entry name" value="snRNP-E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11193">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="11"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC71174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="92" mass="10562" checksum="C259873C9D5D38C1" modified="2024-07-24" version="1">MSGRKVMVQPINIIFSHLQKHIRTTIWLFDNNSFRIEAYIIGFDEFMNLVLDDAEEVYDCGVKAGQDPKPRKELGRILLKGDNITLIQPTQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L6T1</accession>
    <name>A0AAJ8L6T1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_104326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
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    </reference>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
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    </dbReference>
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        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
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            <begin position="4"/>
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    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="285" mass="31656" checksum="1BAD63843204F4DE" modified="2024-07-24" version="1">MSSDKLTLYEFVGSCWANAPKIALSENGFEKGKNVEWVSINLAEGKNFEPEYLKINPAGTVPTLINSKGEKFQDSISSIKEILKISPHPPKVDAHTSTSIIEEIHASSHDPNSTLLFSLNDKDRESKINGLPKGFLQGRQNSLNKLAENPPEEFKEFLLKKKADNQQLLDFYITEPDEATKQAHYSQGKNLWTAVGIALRGVVTQALQKNGGPFAGGSEPSEVDYHIITWLSRTITNTGVEPSSPSNIVIPKLKEYTGGHNLDPVIGKYWDAWLERPSFKDNNIH</sequence>
</entry>
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    <accession>A0AAJ8L795</accession>
    <name>A0AAJ8L795_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase I-specific transcription initiation factor RRN3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_104842</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRN3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019154146.2"/>
    </dbReference>
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    <dbReference type="GeneID" id="30170751"/>
    <dbReference type="KEGG" id="kpin:30170751"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:RNA polymerase I core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007991">
        <property type="entry name" value="RNA_pol_I_trans_ini_fac_RRN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12790:SF0">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12790">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IA RRN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05327">
        <property type="entry name" value="RRN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="333"/>
        </location>
    </feature>
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            <end position="401"/>
        </location>
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        </location>
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        </location>
    </feature>
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        <location>
            <begin position="877"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
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            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
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    </feature>
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    </feature>
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        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010098"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC70890.1"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L7C8</accession>
    <name>A0AAJ8L7C8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="3 4">
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        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
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            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Chromosome 7"/>
    </dbReference>
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        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="13"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC71517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="138" mass="15751" checksum="842E86BC7D70BF03" modified="2024-07-24" version="1">MFSNNNTRAQTSTATRRLMKEYRDLTADPLQDTITAGPVTEDNMLEWEALIQGPEGTPYPADYPLNPFTMTFDPPLLHPNKRWSPVQGVRSVLLSVLSMLAEPNIESGADVECCKLYRDNKPEFERRVREQVRRLLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L7D2</accession>
    <name>A0AAJ8L7D2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 13">Chitin synthase</fullName>
            <ecNumber evidence="2 13">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I206_105492</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 13">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the chitin synthase family. Class III subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 13"/>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059240.1">
        <property type="nucleotide sequence ID" value="XM_070203139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L7D2"/>
    <dbReference type="GeneID" id="30171974"/>
    <dbReference type="KEGG" id="kpin:30171974"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF11">
        <property type="entry name" value="CHITIN SYNTHASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 13" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="565"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="606"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="637"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="684"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="818"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="887"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="15">
        <location>
            <begin position="127"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="WWC71534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="923" mass="103994" checksum="03799D22F98A5440" modified="2024-07-24" version="1">MNPNDPFNDSNQRNRLAPSPRPSHYPPPNQSQVYPPHQYRTPHYDDGGDMGYGGRMGGGVEINGQHMPWVAGEEDDELKPLTSDTNASTTSFIPHSPYMRPLSHMPSSNSVGADFMRRQTLPRRGVTVKKIKLTKGNFIADYAVPGPVSSSVEDKWIIGDKTNEFSHMRYTAATCDPDDFTPENGWRLKTASYNRETELLIAITSYNEDKILYARTLHNVMLNIRDICNTKASKFWRRTAEEGKPGWQRIVVALVADGLGPMDKQVLDVLQTIGVFQDGILKKEVDGKPTVAHIFEYTTQLSIDATPQLVQPHPGDANNLVPVQMIFVLKADNSKKINSHRWLFNALGRQLNPEICVLLDAGTKPGHKAIYHLWEAFYNNQNLGGACGEIHAMIKGGKKLFNPLVAAQNFEYKMSNILDKPLESSFGYVSVLPGAFSAYRFRAIQGRPLEQYFHGDHTMAARLGKKGIYGMNIFTKNMFLAEDRILCFELVAKAKDKWVLQYVKPSKAETDVPEQAAELISQRRRWLNGSFAASVYALIHFFRLYRSGHGPIRMLFFHVQGLYNFFNLIFSWFALANLWLTFSIIINLVPAGSNINLFVTAEVTYWVNLVLMWIYMAFLMLQFVLALGNRPKGEKGLYLLTLWVYAVLAAYLIVCSVILSVVAFKGALSDPGNIGQKLGNLFNATNGVLVAAVMSTIGIYLIASFLYRDPWHMFSSFPQYMLLAPSFTNVLNVYAFCNLHDVSWGTKGSDQAEALPAVSSSKGKDGEVAVVEEPQRNQDELDESFRSVVRRAVAPYKIDEKEEKPSMDDENRTFRTRLVGFWLLSNAGLAISIQTLNGLDTTKQLVEKCVPDNYDPYNGNVTVPMNGTCIQDALKFNTVELQNKQQFYFQALLWATFGLSMVRFLGCLYYFFARQLGRCCRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L7K0</accession>
    <name>A0AAJ8L7K0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_104733</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GOT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012775.2">
        <property type="nucleotide sequence ID" value="XM_019154035.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L7K0"/>
    <dbReference type="GeneID" id="30170640"/>
    <dbReference type="KEGG" id="kpin:30170640"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000137">
        <property type="term" value="C:Golgi cis cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045176">
        <property type="entry name" value="Got1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493">
        <property type="entry name" value="CGI-141-RELATED/LIPASE CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493:SF9">
        <property type="entry name" value="GOLGI TRANSPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC70781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="138" mass="15258" checksum="B3D7E98279A180BD" modified="2024-07-24" version="1">MWLSDGQKIGIALVAFGIFFQFLGIMLLFDGPLLALGNILFLGGLPLIIGPTKTFYFFSRKEKWRGTLCFFGGILLVFFKRPIIGIIIEFVGFIGLFGSFFPVILQALRQTPFIGTFLSLPYIRGAADKLAGVRQSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L8Y0</accession>
    <name>A0AAJ8L8Y0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF895 domain membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_106858</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC72894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010034.2">
        <property type="nucleotide sequence ID" value="XM_019157316.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L8Y0"/>
    <dbReference type="GeneID" id="30173965"/>
    <dbReference type="KEGG" id="kpin:30173965"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF56">
        <property type="entry name" value="DUF895 DOMAIN MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="446"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC72894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="475" mass="51619" checksum="733A62DBFF6A6DFD" modified="2024-07-24" version="1">MSITEDNGVNHQKKSFYRSVPFQIAIAAGVSFTAPGMWDALGGLGAGGAAEPFAVSAANAILYALFAVFCILAGAINNRIGLNWGLAIGAIGYPLYGAGLYTNNKTATTWFMIFGSVCCGISAGFFWAAEAAIIIGYPSPRERGFYLACWQTAKASGPIIGGAITLGLNANRETAGSVGSATYIVFIVLMCLGLPIALCLSPAHKVWRKDGTRVVVHKHASWGAELQAVGRLAISRRILLLVPAFFISYFYNPFVSTWLTSYFTVRSRAFSSFFTPFAGIFSSFIIGSFLDRQSIFIRTRARTAFAVIVIMLCGTWIWAIILQKRFYDNPPVFDWFKGGFGSAYALVFFWTFTGQAFQQFCYWIVGQYTTDLTSLSHHTGILRGLEALGQTVAWALQSQAQVNHFVSIGLNFGILLIAIIPTWIVVSALDHTHEIVVTEEIITSDNKSDEGEGSLSIPSESRTPNLSGVQLPTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L9H6</accession>
    <name>A0AAJ8L9H6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Upf1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">I206_106608</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">RNA-dependent helicase required for nonsense-mediated decay (NMD) of aberrant mRNAs containing premature stop codons and modulates the expression level of normal mRNAs. Also capable of unwinding double-stranded DNA and translocating on single-stranded DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059452.1">
        <property type="nucleotide sequence ID" value="XM_070203351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L9H6"/>
    <dbReference type="GeneID" id="30175870"/>
    <dbReference type="KEGG" id="kpin:30175870"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21407">
        <property type="entry name" value="1B_UPF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18039">
        <property type="entry name" value="DEXXQc_UPF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21400">
        <property type="entry name" value="ZBD_UPF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000097">
        <property type="entry name" value="Regulator of nonsense transcripts 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040812">
        <property type="entry name" value="UPF1_1B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018999">
        <property type="entry name" value="UPF1_CH/ZBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF364">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18141">
        <property type="entry name" value="UPF1_1B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09416">
        <property type="entry name" value="UPF1_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51997">
        <property type="entry name" value="UPF1_CH_RICH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Upf1" evidence="16">
        <location>
            <begin position="81"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="C3H" evidence="15">
        <location>
            <begin position="89"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="CC/SHH/C" evidence="15">
        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="C4" evidence="15">
        <location>
            <begin position="149"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="WWC72644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1091" mass="120070" checksum="68B59E378AF841C5" modified="2024-07-24" version="1">MEFSNFEGASQYGPQDDDLGSVYSAIPNSVINGNQAPSTINGDLTSHFNDLGISTPTFGHGNQGGGRYGEDEFEDREREMLGAGVEHACSYCGIHNPQCVVKCLHCNKWFCNSRGNTSASHIVNHLVKAKHKEVVLHKESALGDTVPECYNCGSKNVFMLGFIPAKSDTVVVLLCRQPCAALTNSRDINWDTSQWSAIIDDRQFLSWLVKIPSEAEQLRARQISLAQISKLEELWRDNPEAKLEDAEAQSGEEEMQPILLKYEDAYQYQNIFGPLVKIEADYDKRMKESQTENDINVRWDMGLNQKRLAWFSMPKLESGEVRLAVGDELRLKFVGTTSGGIKGMQAFNSKSWGGSSTSEGWEGIGSVIKIPNNVSDEICLELRRNDGVPSDCTHGFSVDFVWKATSFDRMQAAMKTFAIDEKSVSGYIYHKLLGHELEPQVLRTQMPKRFSAPNLPELNHSQMAAVKAVLQKPLSLIQGPPGTGKTVTSASIVYHLAKMNPGQVLVCAPSNVAVDHLCQKIHQSGLKVVRVAAKSREALGSDVAFLSLHSQVANADTHPELQKLIQLRNDQGELSQSDERKYKSLVRACEKDILNAADVICTTCVGAGDPRLAKFKFRTVLIDEATQSAEPECMIPLVMGCKQVVLVGDHQQLGPVIMNKKAARAGLSQSLFERLVILGNRPIRLQVQYRMHPCLSEFPSNMFYEGTLQNGVTAPERLRKNVDFPWPVSDTPMFFHQNLGTEEISSSGTSFLNRTEASNVEKMVTKFFKSGVLPAQIGVITPYEGQRSYIASYMQLHGALKKDLYKEVEVASVDAFQGREKDYIILSCVRSNEHQGIGFLNDPRRLNVALTRAKYGTVILGNPKVLSKHPLWLYLLTHYKEKSCFVEGPLSNLQPSMIQFSRPKKSLAAAMDPFKRRESPAHEYMDKTVGRVPGPAAGRFDPSYYRTHNTMSFVPSDAQSVISQAITNSAFPLFPGGNKPKTYTGYASSVISQQPTDSGLISSNHNGHGNTQSTNVGSGGIGYSQFDRLGGVETNQPSLGVGMGMGKRRGSLISEAASASLYAYGYKGGLNGDHEDDVSSVAPSQAGITEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LA25</accession>
    <name>A0AAJ8LA25_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Timeless N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_106966</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC73002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059535.1">
        <property type="nucleotide sequence ID" value="XM_070203434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LA25"/>
    <dbReference type="GeneID" id="30173861"/>
    <dbReference type="KEGG" id="kpin:30173861"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044998">
        <property type="entry name" value="Timeless"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006906">
        <property type="entry name" value="Timeless_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940:SF4">
        <property type="entry name" value="PROTEIN TIMELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940">
        <property type="entry name" value="TIMEOUT/TIMELESS-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04821">
        <property type="entry name" value="TIMELESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0236">DNA replication inhibitor</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Timeless N-terminal" evidence="6">
        <location>
            <begin position="72"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="586"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="942"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1033"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="590"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="953"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1048"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1097"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1137"/>
            <end position="1148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC73002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1197" mass="136491" checksum="AAAF0956A35AC7AC" modified="2024-07-24" version="1">MSYSPIGSPDPYSTLDLDLEHDEGRGISPSLIDEPIDKHAIFLPAVQSLVAALGGYENIETSPGSGKFENIYRPGDSVLGVLKDLKKLWRKDDEDDERTVARCMAKAGLMRELVALLTECTYRGDWGRKISLVACDLIAALTWPIDVASELKEMEDEPAVVTDYASLLRAQLEYKALILQSSQPLRCLLALMLPSLAKPRKDERDERIISLGLHVVRNLLAIKDTTAEGTATGEKEEFANLQSTLILQLNKLTYFQLLLTLASCADKTDFNPFNVLVLDILHLIFRSVKAKDLGQDQDRAPLDNLSKLLDAEKRQKALVSKVGMTRHSRFGTTVAVRAGEQKVILHKQNAISANAGKILDEVKRKRAQKAKKVDELTQIVNFNPDAMRALQGLAKSFIESCFNIFFASILRDIRMERSKIRPTDNVRTFYLTRFFVEYLLVLRHKQEEKGQKEYDLSLGLVAEMAEMDSIRWLFSRMKSSMDDKPPAWTELQASLDCFTQILLLLDAMATSGEEEDIEVAEIVQNNLYYNGDILDSSLSVISQYKDQSVAYLDSVIHFAYVLLRMLEKYSKNKAFMFIRKKKAARKKRKQRDEAMKEPESANKIPEDYGNEEEEAFGPDAEAPSYAEHAFTFKAFEKRFASEPVTNTLLSYLARFQEFEDDEQMKRVVGLMHRQVIKAQAEGLYFKVSTLNLFRKIVDGAHTLPKNDSSKDLNQLIQFVLRKFFKRVAEDPFLIVDAFSSKSRSKWKEISSYQSGSESEDGMAGQRSRIKEKMGQAEIEFKKNKKLSWSKQMEITVGILLKEEKEDLIKWIVDVLEIALASRTEIVISTDGTDAALRQADSDDDNDDERIRDFSGPSKAAIDKFVQHDLTPESDSQKAAVIKDSHFRLMLRLLSFDMVLPDLENQDQPQQPNIEDTKWFLPSHIVPSSISTSLGALQQYLNNPPELTEDPKNLLRRTRPARKRRSNSTDLDEMDLDSETGELVKRVKEKKQRKKKEKEVQIYKSAAFIEDSDDSDDEVTRKFFENEQKLRDEMKALAEQQGNIMRSNGGKRKRKNNKSKGKGKENEDIDELGNQQREDDEDDFLEGNMKVYSQIDDIGMESDDESENDLTQKQNTRRKRPSIAPLDSQLDIEDEFSDRDSGSENETRMYDPNWKRPNQSSSPIPSLDIQMKEQDQIPPTNKGLSGKIRRIIDSDEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MLA9</accession>
    <name>A0AAJ8MLA9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_101561</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008784.2">
        <property type="nucleotide sequence ID" value="XM_019158171.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MLA9"/>
    <dbReference type="GeneID" id="30174837"/>
    <dbReference type="KEGG" id="kpin:30174837"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WWC67651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="336" mass="39081" checksum="650BF7EFF81EA9E2" modified="2024-07-24" version="1">MGIHLKLIFDNFNDFNDDFSSSFSSSIERKGKKKNKNKNKQININQLSLSIQNTFVTSNEEPHPLDPEPLPLPIKRINPDDTQVNRTIQAGLLKALPININPSQIYSELSIVKRDRSSINSFKSILKFDSNSSSSSITKKENNHIVIPSISAYRIKRIDGTNLMNVHNFDSRFTKFENQQIPLTSNKFQKYSPMKSSFNIGYNSDQRSKRWKERKKNIDLKIIINNNNHKDLINSALQTNLIISSNIKTTITPYKIYKNIPIYKSNKKYKIGTFTPITNSFKKNKNKHNKMIQNYNNEFNYFKNKNKDKNENENENENQISIPHTGRFQTNLIQPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MLX7</accession>
    <name>A0AAJ8MLX7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_102266</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058637.1">
        <property type="nucleotide sequence ID" value="XM_070202536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MLX7"/>
    <dbReference type="GeneID" id="30176005"/>
    <dbReference type="KEGG" id="kpin:30176005"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WWC68341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="166" mass="17799" checksum="90816E8D7ABE4D23" modified="2024-07-24" version="1">MNPKDSALDVSQKLKEQIAKLIEILRNPEVNDDEASKALSKIRNSIGKANTQFPTTGVKHNLSHLTKQVGLPLENPKDDDLNKVGSVLADVIKDIIEAVMNIKDDLKKMPLIGSLIVEIDTGLNTLLVGLQLVLSGVVEVLRGLLSGVSGLLKNLGNGLTFGLIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MML9</accession>
    <name>A0AAJ8MML9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyl hydrolase family 88</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_102982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC69046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058761.1">
        <property type="nucleotide sequence ID" value="XM_070202660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MML9"/>
    <dbReference type="GeneID" id="30171704"/>
    <dbReference type="KEGG" id="kpin:30171704"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052043">
        <property type="entry name" value="PolySaccharide_Degr_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886">
        <property type="entry name" value="UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886:SF8">
        <property type="entry name" value="UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC69046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="409" mass="46734" checksum="C3D0C7D0DCAF91B3" modified="2024-07-24" version="1">MAISTLPEYATPMFDYRTYDVKAENIDELVARITKALVELEDKAGIHKYTIADGRVIDSTSWNFWEWQQAIGLYGLFNYYNLKSTEDPSSPEAARTLKIIKEWYTARAAEGGTTKNINSMAVLLTLASLMEVEYNRGGIFTTEEKKLYEAWIDEWAEWAYHDCPRAEQGIYQHITFRLENKNQVWDDTLMMTVLPLAKIGKLLDRPHYIEEAKYQFVQHAQYLMDPINGLWNHGYEFDGEGRGHDWGHIAWARGNCWITIAIPIFLDLIQLPKTDAVYRTLVSVLHRQVDTLVKLQDQETGLWRTLLLDETSYVEASASAGFVAGMFIGIRTGILEENKYIKTAMTGLRACIAQVKPNGEVQNVSKGTPVSTDPNFYKDMPKITVGFGQSLPIMALGEWLRYEKAKSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MP00</accession>
    <name>A0AAJ8MP00_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_102498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058670.1">
        <property type="nucleotide sequence ID" value="XM_070202569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MP00"/>
    <dbReference type="GeneID" id="30171218"/>
    <dbReference type="KEGG" id="kpin:30171218"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC68569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="41421" checksum="36B2E82F478CC411" modified="2024-07-24" version="1">MTSAPFGLMTNVETPYPSSPPSQSPHVPTQAEFDLVQRLAQVKIGPSSYYSIPFPSGRQPHSQLDIPHVLASEEANRAESGLPNAQLSEPSPSTTTYTSLLAMSEQSRDLTESTISTQFHQPAKSTPESSQDITLNITAYIDTGYIWDFWLAEHPIFGMVVLKVVNRSDYPCQIPRLDPFVHPKNLINEALKEEKFYVTHLKHLQGSVVPKYYGLYTSGNTDSYLAIILEYAGVAIGQGYTEIGREWTEKIYEAYKQLHLQGVTQFDIDVRHILIDNADNIRLEGSCIRGRFGGRRDMNLLQSQLPSEYWSGLKDPEAYISGVRQYEAMIGWAPPHIRAHNEKRGVVYDENGFEVKRNGIPEKRRNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MP65</accession>
    <name>A0AAJ8MP65_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carbohydrate kinase PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_104707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012750.2">
        <property type="nucleotide sequence ID" value="XM_019154010.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MP65"/>
    <dbReference type="GeneID" id="30170614"/>
    <dbReference type="KEGG" id="kpin:30170614"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47098">
        <property type="entry name" value="PROTEIN MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47098:SF2">
        <property type="entry name" value="PROTEIN MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="1">
        <location>
            <begin position="163"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC70756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="352" mass="39555" checksum="6546AEBFB4A1D4AD" modified="2024-07-24" version="1">MEGSWNDVRRLPRRIVTLEQFIVDTFTRIGEDGIERPVDQPDQIGGGGTYAIIGARIFIPPSRLGMIIDYTPPTLSKSMRDDLRKYGEDIWAFRERTDGHPTARAVNRYQGQTRGFEYLTKPLLLTPRSLLDTPFGDSLPSTIHFISYPAPRADMILSEILNLQKQLDWDPIIVWEPEEESLEIMERLANDIDIIGPNHNEVLRLFKPAIPSTPTETDLKSIYHDLCIRIANLRPKIGVVIRCGHLGCCYSPTAPKGSVPEVRWIPAYWNVHREGWNQEKVVDPTGAGNAFMGGLAAALDSGKGLDEAVIWGSVAASFTIEQDGLPILTVKNDKELWNGQDPLERVMIMKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MPB0</accession>
    <name>A0AAJ8MPB0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Maltase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_102820</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058727.1">
        <property type="nucleotide sequence ID" value="XM_070202626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MPB0"/>
    <dbReference type="GeneID" id="30171543"/>
    <dbReference type="KEGG" id="kpin:30171543"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF133">
        <property type="entry name" value="P-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042514427" description="Maltase" evidence="7">
        <location>
            <begin position="16"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="9">
        <location>
            <begin position="110"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="8">
        <location>
            <begin position="317"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="10">
        <location>
            <begin position="769"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC68884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="986" mass="110988" checksum="A3D1556CD6DC1AE9" modified="2024-07-24" version="1">MKVLGMLIAPIIALAIPVTEYTLYARDTGQTTPGNTPVLSQQSAYSGDVTKCHGYYVADSSASSSGGLLIYLTLKNNCSAYGEDISYLTVSVEYETNERLHVHLYDNDIHQYQVPEYVLPRPGGGQSSKDSSNLQFDYVNDPFEFWITRKTDSAILFDTRSSKIPTYNETIQIEGTYSNYTVLPSHPLVFEDQYLQISSALPKNANIYGLGEVIAQTGYRRNSTGTVQTFWARDVGDPVDENMYGVHPMYMEVRWNEKQNKLMSHGIFLLNSNGMDVILRDGVIQYRAIGGTFDFYVFSGPAPNDVAAQYAQAVGYPQVMPEWSFGFHLCRWGYTSINDTRTTVQRMRAAGIPLEVQWNDIDWMRAYREFQYDQNYAPAEYKAFVDELHSMNQHYIPIIDAAIGYLMNDTDIFDVYSRGHELDVWMKNPDGTEYVGAVWPGFTVFPDWFNPKMQQVWTEAFQNLSKVVDFDGIWLDMNEPSSFVDGSATNSTIPIKQTTVVPPNYTPQAPPVDFPEGYWPNISGYSGNITVNGTLTYGQNGTAPKNTALRRSHTAELQQAKRWSTPDSDTSDAPDLPIYIPNIRYVDEPPYPIRNQAGRLSAKTVSPNATHYGGLQEYNVHNLWGTMEELHMHNTLLNLKPGQRPFMVARSTFAGIGRKTAHWLGDNYSTFAYMKRSIQGVLQFNLFGIPMVGPDTCGFNGNSDEEVCNRWMQLSAFFPFYRNHNTKLALSQEPYVWESVRDASIKAINARYSLLPYWQTLFAKASEAGLPVIRPLFHEFQNENYLDIDAQFLIGPTILVTPVLQPNESTVNGIFPSENGVFWVDWWTHAKLDNSDGKENVTLDLPLGNIGVHVRSGSVLLIYDQPEYTVKETRDGGYGIIVVLDGKGYAEGDAKIDDGSSYPVTELTCLTFVATENCLTTTTSGNYHIDNNLKSVTIIGVWNKPSRISLNGQEIGDDQIDYDKSVGQVKVTGLRGDLNNKWELKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MT95</accession>
    <name>A0AAJ8MT95_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I206_106554</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059445.1">
        <property type="nucleotide sequence ID" value="XM_070203344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MT95"/>
    <dbReference type="GeneID" id="30175924"/>
    <dbReference type="KEGG" id="kpin:30175924"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000001">
        <property type="entry name" value="Cytochrome c iso-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002327">
        <property type="entry name" value="Cyt_c_1A/1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11961">
        <property type="entry name" value="CYTOCHROME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00604">
        <property type="entry name" value="CYTCHRMECIAB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4 9 11" id="KW-0349">Heme</keyword>
    <keyword evidence="8 9 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="13">
        <location>
            <begin position="9"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="118"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WWC72592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="148" mass="16389" checksum="8EE2A9D1FD431E96" modified="2024-07-24" version="1">MAGDSYTPGDASKGAGIFKTRCAQCHTLEAGGPHKVGPNLHGLFGRKSGQADGYQYTSANVNKGVTWEGQTLFEYLENPKKYIPGTKMAFAGLKKAKDRNDLVAHLDAASVEISYRSHPQDLLRRRKRRKNRKGHPKNHNESPHSFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MTF3</accession>
    <name>A0AAJ8MTF3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA polymerase epsilon subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">DNA polymerase II subunit 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_107230</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Participates in DNA repair and in chromosomal DNA replication.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DNA polymerase epsilon subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC73264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009666.2">
        <property type="nucleotide sequence ID" value="XM_019156948.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MTF3"/>
    <dbReference type="GeneID" id="30173594"/>
    <dbReference type="KEGG" id="kpin:30173594"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016266">
        <property type="entry name" value="POLE2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000799">
        <property type="entry name" value="DNA_pol_eps_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="7">
        <location>
            <begin position="291"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC73264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="536" mass="60044" checksum="DF7A1376372C8768" modified="2024-07-24" version="1">MVNLMRAAIVKVFSTKHSLTLPSAALQYIEQVLLDNEIPQDEWVVGLEFWAREYLKGEDSSSLVSLPALKKAYESLQLGTTDDTDQADPSEINVESHFSVIGSFDMPPVHFDSVRGGFTTGKGKASIAGQASSRSAFLRERWGIIKEIILRNENFTPPAIGGHDRSNYLKLTSTRNLLGRAGQLFLLFGMLSRDPEGRLCLEDGEGRVVLDMEDAVPGEGLFTEGCMVLIEGEYTIDETIRVLAMGHPPSEKRDIARGLHGHVDFLGGGAMSLKEEQKYIPSILANTQVSFVVLSDVWLDHPRTIPALRRMLEGYAEAVEYRPMAFVFCGNFSLKGWEGDGGLKRYTNGFNALTDLLMEFPLLHSSNFIFVPGPLDPWSSTTLPRPAIPSVFASRLIQRIPKARFVSNPCRLRYFGMELVICREDLMGKMVRNLVGVKKEEGVDMKRYLVQTILDQTHLSPLPINIRPTLWEYDHALRLYPMPSALILADKYERYELTYEGCHVFNPGRFVGSGGEGGGEFEWSMYYPATGRSERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HSA7</accession>
    <name>A0A1B9HSA7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_07833</name>
        <name evidence="2" type="ORF">I206_100018</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700119">
        <property type="protein sequence ID" value="OCF46163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007382.1">
        <property type="nucleotide sequence ID" value="XM_019159518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HSA7"/>
    <dbReference type="STRING" id="1296096.A0A1B9HSA7"/>
    <dbReference type="GeneID" id="30176202"/>
    <dbReference type="KEGG" id="kpin:30176202"/>
    <dbReference type="OrthoDB" id="3335358at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.20">
        <property type="entry name" value="Protein of unknown function DUF952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009297">
        <property type="entry name" value="DUF952"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34129">
        <property type="entry name" value="BLR1139 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34129:SF1">
        <property type="entry name" value="DUF952 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06108">
        <property type="entry name" value="DUF952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCF46163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC66118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="148" mass="16863" checksum="97EE81B7AEDCB569" modified="2016-11-02" version="1">MSAVPKYIYKIIPHSSVDTRFTFPVPIPSSHQFLTELDLNDRFIHFSAAEQIPTTLNLFFKEDPAVTLLRVEVARISAWKKVGWVLPDQTPRTGDMPYLCAHAWPVPLEGEYVESFKELFRQSANGEKSAQGAWDGSLAEKEIKDWLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HSH8</accession>
    <name>A0A1B9HSH8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rab family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_07895</name>
        <name evidence="4" type="ORF">I206_100080</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
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                <person name="Imamovic A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">CBS 10737</strain>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
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                <person name="Imamovic A."/>
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                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
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                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="7">CBS 10737</strain>
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    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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            <strain evidence="8">CBS 10737</strain>
        </source>
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            <dbReference type="EMBL" id="OCF46226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC69811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="503" mass="55775" checksum="BF093122DD90B8D2" modified="2016-11-02" version="1">MTSSNILTTHGDDDKNKQMEHDGTAVIQQQVANDMNDDTREPDQAYLRAPKRLRWFRGTLFQMFLFGLLSFSGPAMSDAIDNLGGGGLATPYTANAANSANYATACAMTLFGGPLINKMGIKWSCIIAATFFPIQGASYYVNSKYGTQWFVIFVGAIGGFFGGLLYVAESTAMLSYPQPHQRGKYIGIWVSMRNSGQLLGGAISLGVNVKTAGVGAVSITTYLIFIVLECLGLPGALLLSPTSKVRQTDGRPVPLAAPQSWKIETKLLLKHIVHKRTLLMFFPAFYSFFYGGVYTTYLSLHFSVRARALSSFLYPLVTIMLCTAFGRLIDNKRWSQKTRAWIGFAFWAVPQAAVFIWTAILYAQFEKHNLKGIDYTNNTADWFRCYLPYLIIQSTGYACQLYLYWLLGCFSSDVKSSARTGGLFRCFETAGQAISHGINSRTSDKRVPLYINIGIYCLMVPTLTMLIRMVPSNPQTYDDVTEEKAVEAVNETQETMAVEARGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HSP8</accession>
    <name>A0A1B9HSP8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Translation initiation factor 2 subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_07774</name>
        <name evidence="6" type="ORF">I206_103822</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700118">
        <property type="protein sequence ID" value="OCF46294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC69879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007513.1">
        <property type="nucleotide sequence ID" value="XM_019159461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HSP8"/>
    <dbReference type="STRING" id="1296096.A0A1B9HSP8"/>
    <dbReference type="GeneID" id="30176143"/>
    <dbReference type="KEGG" id="kpin:30176143"/>
    <dbReference type="OrthoDB" id="1685042at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04452">
        <property type="entry name" value="S1_IF2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.190:FF:000004">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1130:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000015">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1130">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.190">
        <property type="entry name" value="Translation initiation factor 2, subunit 1, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044126">
        <property type="entry name" value="S1_IF2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024055">
        <property type="entry name" value="TIF2_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024054">
        <property type="entry name" value="TIF2_asu_middle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011488">
        <property type="entry name" value="TIF_2_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07541">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110993">
        <property type="entry name" value="eIF-2-alpha, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116742">
        <property type="entry name" value="eIF2alpha middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="4">
        <location>
            <begin position="13"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF46294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC69879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="300" mass="33860" checksum="56FD4BC916E1C4E2" modified="2016-11-02" version="1">MPRFYENKYPEVDQLVMVQVQSIEDMGAYVKLLEYDNIEGMILLSELSRRRIRSVQKLIRVGRNEVVVVMRVDPDKGYIDLSKRRVSAEEVVKCEEQYEKGKAVDSILTQVAKKRGVSPESLYEKIAWPLHKQYGHSYEAFKASISEPEAIFGSLTLDEDTLTDLRSAIARRLTPKPVKVRADIEVKCFSYNGIEAIKRALNAGEKLSTEEIPIKVRLVAPPLYVMSTTSTDKSGAIELMDKAVELIGDSITKEKGDMTIKMRPKVVSETEDAELKALMERFEAANMDVAGDDDSDEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HT50</accession>
    <name>A0A1B9HT50_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">ATP-binding cassette, subfamily D (ALD), peroxisomal long-chain fatty acid import protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I206_07683</name>
        <name evidence="16" type="ORF">I206_102313</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI894017">
        <property type="protein sequence ID" value="OCF46449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007668.1">
        <property type="nucleotide sequence ID" value="XM_019159374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HT50"/>
    <dbReference type="STRING" id="1296096.A0A1B9HT50"/>
    <dbReference type="GeneID" id="30176052"/>
    <dbReference type="KEGG" id="kpin:30176052"/>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
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    </dbReference>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="494"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022967"/>
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    </evidence>
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        </source>
    </evidence>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HTF4</accession>
    <name>A0A1B9HTF4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP synthase subunit e, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_07405</name>
        <name evidence="2" type="ORF">I206_106706</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894016">
        <property type="protein sequence ID" value="OCF46552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007771.1">
        <property type="nucleotide sequence ID" value="XM_019159099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HTF4"/>
    <dbReference type="GeneID" id="30175774"/>
    <dbReference type="KEGG" id="kpin:30175774"/>
    <dbReference type="OrthoDB" id="2141050at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39218">
        <property type="entry name" value="OXIDOREDUCTASE 14 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39218:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 14 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCF46552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC72742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="10510" checksum="C964093A730E252D" modified="2016-11-02" version="1">MTLISTILGFSAFGFGARCFQLGLQHRPIFDAPSGHLISTAVFGAVGYGAYHADKKQTALLAEKKKILIERREKENLEWESKKGQNTHQQQHVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HTG9</accession>
    <name>A0A1B9HTG9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Calpain catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_07419</name>
        <name evidence="10" type="ORF">I206_106692</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
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                <person name="Litvintseva A."/>
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                <person name="Mohammad A.W."/>
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                <person name="Litvintseva A."/>
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                <person name="Dewar J."/>
                <person name="Goldberg J."/>
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                <person name="Hansen M."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="Zeng Q."/>
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            <strain evidence="10">CBS 10737</strain>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
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                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Goldberg J."/>
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                <person name="Imamovic A."/>
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                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
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                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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                <person name="David-Palma M."/>
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                <person name="Bowers K."/>
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                <person name="Mohammad A.W."/>
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                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
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                <person name="Cuomo C.A."/>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
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                <person name="Young S.K."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
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                <person name="Chapman S.B."/>
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                <person name="Goldberg J."/>
                <person name="Griggs A."/>
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                <person name="Hansen M."/>
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                <person name="Nusbaum C."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="Dromer F."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="David-Palma M."/>
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                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="8">CBS 10737</strain>
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    </reference>
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    </comment>
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        <property type="protein sequence ID" value="OCF47051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC68159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008270.1">
        <property type="nucleotide sequence ID" value="XM_019158524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HUV6"/>
    <dbReference type="STRING" id="1296096.A0A1B9HUV6"/>
    <dbReference type="GeneID" id="30175194"/>
    <dbReference type="KEGG" id="kpin:30175194"/>
    <dbReference type="OrthoDB" id="690068at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051732">
        <property type="entry name" value="USF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46117">
        <property type="entry name" value="FI24210P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46117:SF3">
        <property type="entry name" value="FI24210P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="279"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="102"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="309"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="485"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="487"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="537"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCF47051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC68159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="575" mass="63312" checksum="B3C4F338E97ADE90" modified="2016-11-02" version="1">MTTIKTEGFKVPGVDNGSNRPSMHRPFSDGSMTVETNLLTSLMSGSPHQMSMNMVSPYSFSSSLPAQTHTFDYSMNSPLSTSADRFHPAAIFNAIKFGVDNPEPPINFGNEDNQSQDERSRSQSSSRSSHIGKAPSSRSRTARKSMNDVRPPSGSIQPRGRTNVTGRAQSFSGAAQMGITNTIHEIKPMGLGIGLDTHVEGEQTDSISPPDFGLSGNFGMSIPHNENDNVSWGSGSVPSMVPGSLGSFGETVDDAVIDSPMTPAKPLHLLSDESYKKQRRRECHNQVEKRRREHINAKIEELSQLLPPAYNLPNDEEAIEDDDEEEGKPQLTAGGKKKKTKRTGSTTTKAALKDAVQCKGRILSQSVQYIRDLKHLTDLQSGRIAHLENMLLTYGVNTTFQPTPMANPQSSLFWMNDNNLPNTLNQQPTFDLSGAHNLEAMRPSPELERQFSFDHMNLDARNWGNSMMNGNGQTHELAHDILMSFEPSPQNTTSSTSANNIRRSSESVSSSASFDRDNTEALELQSPLSMNMSISDMRGRQRERTVRKDSQAELQMSMSALLSQGRDESDGGMRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HV42</accession>
    <name>A0A1B9HV42_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_06923</name>
        <name evidence="9" type="ORF">I206_101985</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV700117">
        <property type="protein sequence ID" value="OCF47145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC68066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008364.1">
        <property type="nucleotide sequence ID" value="XM_019158618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HV42"/>
    <dbReference type="STRING" id="1296096.A0A1B9HV42"/>
    <dbReference type="GeneID" id="30175292"/>
    <dbReference type="KEGG" id="kpin:30175292"/>
    <dbReference type="OrthoDB" id="1939598at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14705">
        <property type="entry name" value="bZIP_Zip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR ATF 4/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044:SF14">
        <property type="entry name" value="CRYPTOCEPHAL, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="195"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF47145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC68066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="290" mass="31367" checksum="E637B79E67D4F206" modified="2016-11-02" version="1">MFPDLPEHLQALNALPGNTPPSAAMNPEQEEAFWGFLHADELFRNFGNAPSPSEQNGLLQEDKSTYNHNQQIIAPAPTPIANTPTQSQQENKPGAPTLESFIAAYIGQSSSHGANTSSAHPHALPPNYLIPIPTPYTQNSIDTPQMDTPAGINTSDVLPGSASIFGDSLVESPEDRISGAKRLKQLGAPQVEIEEDKRRRNTEASARFRAKKKEREQALERRAKDLEAQLAALQSENTSLENENRLLKAIVLNGPSGQSLPASITSSSNGNPPSLQAALASLTQKRKRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HV76</accession>
    <name>A0A1B9HV76_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Microfibrillar-associated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_06955</name>
        <name evidence="4" type="ORF">I206_101954</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="Dromer F."/>
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                <person name="Zeng Q."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
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                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
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                <person name="Young S.K."/>
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                <person name="Gargeya S."/>
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                <person name="Litvintseva A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="David-Palma M."/>
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                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
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                <person name="Yurkov A.M."/>
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                <person name="Cuomo C.A."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="Heitman J."/>
                <person name="Chen Y."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
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                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="32"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF47274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC67938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="376" mass="44332" checksum="BF6799606DBD0620" modified="2016-11-02" version="1">MPVTRSGKSSTPKKPKHLIKPSTYVFDPSRITLPNEIIIRVLSILADDRKQKSLAKCCQVSKQFYAMSSPLLWNHLRLTPWKTDEGGKLIEDPSKYRCGALKTQQKNGKALKNDVNTFSLYHHSMSWCKSDTKSTLQLPNAQTLHLYPKRITAMHSDPWYATPPCRLLKNVQPKELILHNVSIVHQDLMVDINCQKLFETVEVLVLITNALYSDWHWESPKPPWVPHLRQVYYVFEPIPNPYPYDLEEEENLRYLINDIMWNLKHQLRRATVTFVNLEALEYASRGSLAAGEPRLKTKFERLLFAMIDDFPSSSRFSTKEEREERKRTVRIITLQEFYQEDGWWRYVDRQDMDEWVKIMQSNTQEAVEEREQQLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HVT3</accession>
    <name>A0A1B9HVT3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Solute carrier family 39 (Zinc transporter), member 1/2/3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_06280</name>
        <name evidence="11" type="ORF">I206_101750</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008603.1">
        <property type="nucleotide sequence ID" value="XM_019157990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HVT3"/>
    <dbReference type="STRING" id="1296096.A0A1B9HVT3"/>
    <dbReference type="GeneID" id="30174649"/>
    <dbReference type="KEGG" id="kpin:30174649"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004698">
        <property type="entry name" value="Zn/Fe_permease_fun/pln"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00820">
        <property type="entry name" value="zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF32">
        <property type="entry name" value="ZINC-REGULATED TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="189"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF47384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC67833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="386" mass="41803" checksum="9E60006A10E77215" modified="2016-11-02" version="1">MADVDNGGNNMLDVEDSDPCAIDNSDSHHGLRIGAIFIILVTSLAGTLTPIIFRHSSAIPTPVFEFAKFFGSGVIIATAFIHLLAPAWDELTSECLSGTWTEYDWAPAIAMAAVYGIFFAEVAAYRIGTKRLERLGVDYSSHAHDDTDAHAHDHNLDAPLNVDTSLPASQHHIHPLASNIHSHHHNDITEQTLSSSSNTEKQIKKSDIESNSNYDNDEPISNSEASAQLVAVGVLEFGVVLHSIIIGLTLGVTNEFITLFIVIIFHQMFEGLGLGSRLASLNLPQKMKIYRWIAALFYSICTPIGISIGIGLKNSYDGNGKTANIVSGVLDSTSAGILLYTGLVELMAHEILLNPRMMKSSNGKLSYIFICMLLGSGLMALLGRWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HW34</accession>
    <name>A0A1B9HW34_9TREE</name>
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        <recommendedName>
            <fullName evidence="5">homocitrate synthase</fullName>
            <ecNumber evidence="5">2.3.3.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I206_06386</name>
        <name evidence="17" type="ORF">I206_101644</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>acetyl-CoA + 2-oxoglutarate + H2O = (2R)-homocitrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12929"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58884"/>
            <dbReference type="EC" id="2.3.3.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:12930"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-IPM synthase/homocitrate synthase family. Homocitrate synthase LYS20/LYS21 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.14" evidence="5"/>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008704.1">
        <property type="nucleotide sequence ID" value="XM_019158091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HW34"/>
    <dbReference type="STRING" id="1296096.A0A1B9HW34"/>
    <dbReference type="GeneID" id="30174755"/>
    <dbReference type="KEGG" id="kpin:30174755"/>
    <dbReference type="OrthoDB" id="2015253at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00028"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004410">
        <property type="term" value="F:homocitrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07948">
        <property type="entry name" value="DRE_TIM_HCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.260:FF:000002">
        <property type="entry name" value="Homocitrate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000032">
        <property type="entry name" value="Homocitrate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02222">
        <property type="entry name" value="Homocitr_synth_fung_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050073">
        <property type="entry name" value="2-IPM_HCS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048253">
        <property type="entry name" value="DRE_TIM_HCS_fun_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011872">
        <property type="entry name" value="Homocitrate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054691">
        <property type="entry name" value="LeuA/HCS_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02146">
        <property type="entry name" value="LysS_fung_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277:SF48">
        <property type="entry name" value="HOMOCITRATE SYNTHASE, CYTOSOLIC ISOZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277">
        <property type="entry name" value="HOMOCITRATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22617">
        <property type="entry name" value="HCS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="15">
        <location>
            <begin position="69"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="461"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCF47485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="WWC67732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="486" mass="53298" checksum="0DC1D9A24F575842" modified="2016-11-02" version="1">MCPPPDQPVTSNGDEEMVPIINDGPHISSSTNGQVKKINENVSEQPPAVKSHKGLYGRASDFLSNTSNWSIIESTLREGEQFANAFFTLETKIKIAKMLDEFGVEYIELTSPAASPESKAHCEAICKLGLKKTKILTHIRCHMDDARLAVETGVDGVDVVIGTSSFLREHSHGKDMTWITKTAIEVIEFVKSKGIEIRFSSEDSFRSELVDLLSIYRTVDKIHVNRVGVADTVGCADPRQVYDLVRTLRGVVSCDIECHFHNDTGCSIANAYAALEAGATHIDTSILGIGERNGITPLGGLIARMMVADPDYVKSKYKLSMLRELENVVAEAVEISVPFNNYITGFCAFTHKAGIHAKAILANPSTYEILNPADFGMTRYVSIGHRLTGWNAVKSRVEQLNLNLTDDQVKDATAKIKELADVRTQSMEDVDMILRIYHTGIQTGDLKVGQSHVLDRLLEKHMPSREGSPNGSANGNKRARIEGASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HW93</accession>
    <name>A0A1B9HW93_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_06449</name>
        <name evidence="2" type="ORF">I206_101581</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008766.1">
        <property type="nucleotide sequence ID" value="XM_019158153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HW93"/>
    <dbReference type="GeneID" id="30174818"/>
    <dbReference type="KEGG" id="kpin:30174818"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCF47547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC67670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="241" mass="28033" checksum="486633C9A43A66F8" modified="2016-11-02" version="1">MSENELNISELQVKDETEIISWNNQTHRDIGAKILNEAAKSREEPFISKAFKQEDWEEWFDFLAVGGVNRTIERPKAIKEKAMIYLIEKMKINFQIYNMDSREIRELIIDLPDYLYAYEIRKKLGNEYNEEIWIRKEFILTAVVLFLGGENPTNLTTRQATFSASTFYLIKKYIPQRTIDQIKEALVTYFGHIQQAFDGLTEKVREHGLGFFGDDLTEADIQEMKEHGAGAGAEGLFEEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HWM2</accession>
    <name>A0A1B9HWM2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">CAAX prenyl protease</fullName>
            <ecNumber evidence="15">3.4.24.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">I206_06578</name>
        <name evidence="19" type="ORF">I206_101450</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Proteolytically removes the C-terminal three residues of farnesylated proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 15">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic side chains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.24.84"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14 15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Endoplasmic reticulum membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 15">Belongs to the peptidase M48A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.84" evidence="15"/>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008892.1">
        <property type="nucleotide sequence ID" value="XM_019158279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HWM2"/>
    <dbReference type="STRING" id="1296096.A0A1B9HWM2"/>
    <dbReference type="GeneID" id="30174947"/>
    <dbReference type="KEGG" id="kpin:30174947"/>
    <dbReference type="OrthoDB" id="360839at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07343">
        <property type="entry name" value="M48A_Zmpste24p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.10:FF:000002">
        <property type="entry name" value="CAAX prenyl protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027057">
        <property type="entry name" value="CAXX_Prtase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032456">
        <property type="entry name" value="Peptidase_M48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10120">
        <property type="entry name" value="CAAX PRENYL PROTEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16491">
        <property type="entry name" value="Peptidase_M48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 15" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 14 15" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 1 N-terminal" evidence="17">
        <location>
            <begin position="53"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="16">
        <location>
            <begin position="235"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="394"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00060927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU366005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OCF47673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="WWC67541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="472" mass="53513" checksum="42F4CD2B15A62FC6" modified="2016-11-02" version="1">MTNSVVNAVDGVITYLAGIFDNPSINYKELVILSTWVQTAFEVYVLRRQMPCYERPLPPPALKQHISKETFTKAQSYSKDKTRFALLKLIFDQFLGWGLIKLGAYSGLWNFSSKLLSNIGISPNRVITHSLTWMTVLTLISSIPGLPWSYFQTFVLEQKHGFNKSTVKLWITDTIKTYALAAVIGLPVLAGFLKVIEWAGKGFVPWLMVFLISIQLTLQIVYPTFIQPLFNKLEPLPQGELRTKVEELAGQLGFPLKHLYVIDGSKRSSHSNAYFYGLPWSKHIVIYDTLIKDSSVDEVVAVLGHELGHWYHAHPTKLLLVTQLHLLLTLTIFSIFINNKSLYASFGFDPSLAVKAPQPICIGFMLFQLVFEPTDALVKFFLNAETRRMEYQADEFAVQLDKKSDLSSALIKLHITNLSSPHNDWLYSMYHHSHPTLPERLNAMDNYTGENTLKLKGKPAEGEVETEAKKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HWX4</accession>
    <name>A0A1B9HWX4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nodulin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_06673</name>
        <name evidence="9" type="ORF">I206_101358</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008985.1">
        <property type="nucleotide sequence ID" value="XM_019158372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HWX4"/>
    <dbReference type="STRING" id="1296096.A0A1B9HWX4"/>
    <dbReference type="GeneID" id="30175042"/>
    <dbReference type="KEGG" id="kpin:30175042"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010658">
        <property type="entry name" value="Nodulin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF160">
        <property type="entry name" value="NODULIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06813">
        <property type="entry name" value="Nodulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="461"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="485"/>
            <end position="510"/>
        </location>
    </feature>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HXE9</accession>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Shea T."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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            <authorList>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
        </source>
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        <source>
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<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1B9HY67_9TREE</name>
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        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
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        <text evidence="11">Subunit e, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
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        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
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        <text evidence="2 11">Belongs to the ATPase e subunit family.</text>
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    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008386">
        <property type="entry name" value="ATP_synth_F0_esu_mt"/>
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    <dbReference type="Pfam" id="PF05680">
        <property type="entry name" value="ATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4 11" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
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                <person name="Young S.K."/>
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                <person name="Gargeya S."/>
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                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Murphy C."/>
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                <person name="Roberts A."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
                <person name="Sun S."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Dewar J."/>
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                <person name="Imamovic A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Murphy C."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">CBS 10737</strain>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
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                <person name="Imamovic A."/>
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                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
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            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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    <sequence length="121" mass="12502" checksum="6C8F703EDE9A09BC" modified="2016-11-02" version="1">MSFLRATSTLPLSRASYRALSTSSIRSKSLTESVKDAADAVNKKVGQTLASGLESAQTATEQAKGTVNEKTPSQSEIDSKASSVAQGAKETAESARQNANQALGSAAGKARDAADEVNKRV</sequence>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
                <person name="Chen Y."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="Young S.K."/>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
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                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Imamovic A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
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                <person name="Imamovic A."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
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                <person name="Zeng Q."/>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Consists of at least two heavy chains and a number of intermediate and light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC73019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009912.1">
        <property type="nucleotide sequence ID" value="XM_019157194.1"/>
    </dbReference>
    <dbReference type="STRING" id="1296096.A0A1B9HZI5"/>
    <dbReference type="GeneID" id="30173842"/>
    <dbReference type="KEGG" id="kpin:30173842"/>
    <dbReference type="OrthoDB" id="447173at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003006">
        <property type="term" value="P:developmental process involved in reproduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072384">
        <property type="term" value="P:organelle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000122">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000001">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.130:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000005">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000001">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000071">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000517">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000003">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.280:FF:000004">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000004">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000373">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000075">
        <property type="entry name" value="Dynein heavy chain, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000013">
        <property type="entry name" value="Dynein heavy chain-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054354">
        <property type="entry name" value="DYNC2H1-like_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF4">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22597">
        <property type="entry name" value="DYN_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0243">Dynein</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="1931"/>
            <end position="2069"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="2591"/>
            <end position="2741"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="2933"/>
            <end position="3099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="3195"/>
            <end position="3257"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="3413"/>
            <end position="3461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OCF48693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="WWC73019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="4613" mass="520986" checksum="A9D1C1A234FC4757" modified="2016-11-02" version="1">[encoded data, 4613 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HZN9</accession>
    <name>A0A1B9HZN9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acyl-protein thioesterase 1</fullName>
            <ecNumber evidence="3">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Palmitoyl-protein hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I206_05527</name>
        <name evidence="15" type="ORF">I206_106929</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="3"/>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC72965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009965.1">
        <property type="nucleotide sequence ID" value="XM_019157247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HZN9"/>
    <dbReference type="STRING" id="1296096.A0A1B9HZN9"/>
    <dbReference type="GeneID" id="30173896"/>
    <dbReference type="KEGG" id="kpin:30173896"/>
    <dbReference type="OrthoDB" id="2418081at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000010">
        <property type="entry name" value="Acyl-protein thioesterase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF17">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="13">
        <location>
            <begin position="10"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCF48746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WWC72965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="238" mass="26333" checksum="3EC082A67D0DCC77" modified="2016-11-02" version="1">MSTQLKHLKVSPKEAHTATVIFLHGLGDSGHGWLPVAKSLWNTFPNVKWILPHAPEIPITLNGGMKMPGWFDLSSLNNLTNSKYDDEKGLLNSIEKIDNLIQNEINLGIPENKIIIGGFSQGGVISILTALTTKRKNLGGVIGLSTWLALNHKAEEIKTDHANQIPIFWGHGTADPVVNYEYGQQSIEMLKNLGFPLLSPGTTFQRPGIRFESYKGLPHSSSPQEIEDLKQWLIEALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I0H2</accession>
    <name>A0A1B9I0H2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_04702</name>
        <name evidence="12" type="ORF">I206_105882</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Homotrimer. Homotrimerization increases the affinity of HSF1 to DNA. Interacts with transcriptional coregulator SSA1 on chromatin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC71923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010234.1">
        <property type="nucleotide sequence ID" value="XM_019156432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I0H2"/>
    <dbReference type="STRING" id="1296096.A0A1B9I0H2"/>
    <dbReference type="GeneID" id="30173071"/>
    <dbReference type="KEGG" id="kpin:30173071"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000027">
        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="10">
        <location>
            <begin position="173"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="274"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="514"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="348"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="366"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="387"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="522"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCF49015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC71923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="716" mass="79564" checksum="7A5A279EA3E6C077" modified="2016-11-02" version="1">MSDNGQAQRTAETPSKRKLSLRLEPRPSNSIADKKAKIEPGHTTRRCDSAELTDEVEQPLTATSTRFTHSSYSSPGSSTEDDRDRAFRDRMAGRQDKPIPQDRRRPSYPSAWMVGENERSVISSSGSSSRQPDRSQLHHSSTNNSINASRNSSPPPSFNLSSGQPLVNPPQKTQAAFVGKLYSMLEDEDIAKTGLIYWSAEGTTFTCPNPQEFSKVVLPRFFKHNNWQSFVRQLNMYSFNKVNDIYTTTIDPQAWEFRHSLFRRGEPHLLASIKRKSSRPSANDGGQPISPTEDVTELVKPVAGWMRDMPGQSGPLTSQPNVLRLASPPQGQRSIVYPYSGPNEDSRPTTTGGLWESRQPSSHGNGPPPLSSNRMPPPLQDQTNLRDQSHIPRFHPDSARPPLSGQRFLPTGGFPDSPYYSQRGEPPSVEALYCQITALEDKLQKMTEVLNHDRIEHVRYNLDFTSYLLQMSGWASGDKPSPEMKALQDTLNRQNADMKQRYEDLMASDALTIMASGGGTNGRDRTSNIDRDRDDKRSRLPFENTTPNVLNSARSLQAVLPTPRLPSSNNISRGATPLVSPSVREFSDITPLVSRPPTSFSNSISGDSHSLSSQPENMNLPLPLNLTRSSNPNVSYFQAPSQSSGLITPTINGFASGNEMEKNEIRLTPRQEPTSIKTSMNKLKENGSSKIEEDLINDNKIKDDIKPKAGLRNLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I0J5</accession>
    <name>A0A1B9I0J5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TPX2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_04746</name>
        <name evidence="3" type="ORF">I206_105923</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC71964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010278.1">
        <property type="nucleotide sequence ID" value="XM_019156476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I0J5"/>
    <dbReference type="STRING" id="1296096.A0A1B9I0J5"/>
    <dbReference type="GeneID" id="30173115"/>
    <dbReference type="KEGG" id="kpin:30173115"/>
    <dbReference type="OrthoDB" id="2575493at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="463"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="487"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF49059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC71964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="664" mass="74137" checksum="50FD5428964C7607" modified="2016-11-02" version="1">MSRQPPQTPWVGLPRFQDESLLIDVQPIFDVSLGEDMGNDSIGWADDKPSVIETKKGNTPVDTSLDLGDYLPEEETRYDISDVEQARTADNTNLNAEVPPYKPIVSHTHKREGSQSLIPVAGPYKKTKPPREKKDDDLYNRRLSDSLRRSSSGNLNDLYISQTYSHIPRLVQPSSSKLPVPPKIAKLPKNTASSRLKAGLQNQLKQHDMDGCTIDRGRILNDNDTTSRIQENSGEQQTSALSRYLAKSDVLIPRSIIHTSNETAAEAKQQNRLPLNTSACVAASSIVQNMDTVNEIPHEASASIRHDSPFSLSSSVSEALSSHTQKSSVNYDGVDEAGLSRSRRSSMSDKVVDFFSNLLNRSTSSSSLRNEEVSINDQEDDPEDTVRFEEYEELYKSEIQLGQERSKIEAATQEQVQVNQSNKLNRGTNTVKNVQRMRGLTKPIPFSRSLHIRSDRNIRDKSSSSVSTNVKSKSIALQPTTKSNIQSSSSSSSSSSSIKKGIDRPLSIKPSTFASKAISKLPPPGKGHLISNSSQPISIKSIERVKNLNERKNVFERLSSNNSTKNNNSLFEEKGKGKLIEKTNLNLNLNLTIPLKGHTPGKLSNLRSIERNKFNELIEKNQKQKEFLIYDKNLKKQIEDDLIYLNSRKQTVIWAKPIPAMYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I151</accession>
    <name>A0A1B9I151_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_04951</name>
        <name evidence="6" type="ORF">I206_106127</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010482.1">
        <property type="nucleotide sequence ID" value="XM_019156680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I151"/>
    <dbReference type="STRING" id="1296096.A0A1B9I151"/>
    <dbReference type="GeneID" id="30173320"/>
    <dbReference type="KEGG" id="kpin:30173320"/>
    <dbReference type="OrthoDB" id="340962at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20524">
        <property type="entry name" value="CYCLIN_CCNH_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20525">
        <property type="entry name" value="CYCLIN_CCNH_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000095">
        <property type="entry name" value="Cyclin Ccl1, putative (AFU_orthologue AFUA_5G07030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031658">
        <property type="entry name" value="Cyclin_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16899">
        <property type="entry name" value="Cyclin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0195">Cyclin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="4">
        <location>
            <begin position="102"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="411"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF49263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC72167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="448" mass="50009" checksum="A4760E15403FFB63" modified="2016-11-02" version="1">MALSDQVQPEAGPSTSSSSATLQPSPSPYHESSQFRHWRYSPASLTLIREELNAKSVEIVAKNTELEKEAQISLGHSYTDPPPPTAYLTVSDELLLLRFYCSQISKICRHGFGLPDIVETTAISYLKRFYLKNSVMEWHPKNIMPTCLFLACKTTNYPVLMDQFISKFSKLTPDDIIDTEFLVAQSLGFEFWIRSSEKTLRGWSLDLQNQPNPQVDVIQKSLSEALKYLSQSLLTDLEFIYTPSQISLACFHISNPKVIEDFLDFRYSSFKPNTTPSLDEDQESKDENNQLPYGMTKDRLLEILSDIEKVIKMDGSIDIDMKKVKEIDKRLKNCTNPEKIPGTALYVKRKREKEVNEAANKAAKTSKAARATLDRESVFGSILSIPSSNNSPRKPLSPKVTMNGVPVSAGVMKPGGAEVDLEDDGMGVRDENGIVLGGKGLKDVGLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I1E1</accession>
    <name>A0A1B9I1E1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dilute domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_05016</name>
        <name evidence="6" type="ORF">I206_106191</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010544.1">
        <property type="nucleotide sequence ID" value="XM_019156742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I1E1"/>
    <dbReference type="STRING" id="1296096.A0A1B9I1E1"/>
    <dbReference type="GeneID" id="30173385"/>
    <dbReference type="KEGG" id="kpin:30173385"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051020">
        <property type="term" value="F:GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15473">
        <property type="entry name" value="Myo5p-like_CBD_DIL_ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037986">
        <property type="entry name" value="Myo5p-like_CBD_DIL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052072">
        <property type="entry name" value="Vascular_dev_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027:SF6">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN YPR089W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="236"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="4">
        <location>
            <begin position="480"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="600"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="836"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="931"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1008"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1213"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="318"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="603"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="646"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="940"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1217"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1244"/>
            <end position="1254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF49325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC72229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1254" mass="141992" checksum="57B2E64EFD1AD910" modified="2016-11-02" version="1">MTNTSTSPQLEGGISPSFKTYDSTLISTSRKSTFPISNPITTSNKNSPNLLNNPQLSHILVPESPLIDLTMSSPDHRNLIETASITSSTCGVIGEEKSKNSIKRSGSYKRQIEPRFLNDPSPSNILSLLETQESSNNDDNGDLGRELRIGLILRRSIKWAIERSDTELIGWLVGLEGKWADILDFQANQLEDEEGWGIVGMAIQASCHRQETEECVRIIVGRWGLEVGQRGGRDRTGWTPLHLAALISTPPLISFLLSRGSSPHALTNRGLTPLDLVVGMPDREDVALFLEHATCHGESSTTPKTATTIIPHFPPARQAMLERRRRHATLKKEAIEREETKQQLELERETWLRERARMVDVDPELLIKPLPTKRDSKTPSDDSGLGWMGYELDLEAERTDDEDSEYGEDDDFDVNQLDLNSNMLVFSLSHLPTIFDILITEYIPVCQPLRQRTLPANALYLYARFAQYKCDETWLEELIEGIVDRIEQGVYSNVENLAYLAFWAYNSAVLLHLLKSDPPIHAACEHLGLLSMMEELINAIHVFVIRVAERRIDMYLDAAILDYETLEDFNDIRFEGEWSLFRSFAPKKKRETPRAASIFAPSPAQSSGQDSPHSPSVYGTPHRTPNRHQSMSDLRLGTGTPRSISHDSSISGHSGFSHMTPTVELEINPSRITDILSGVLLILQLYEVNPAIVVQAFSQIFFWISCELFNRILAQKKYLCRTKALQIKMNITVLDDWVRANGLPAQTATKHLEPVTQLLQWLQCLSQIKEFDTLIGTMQNMRAINPLQMRRAVRDYKYEVNEGKMNEECAQYLAQLQKDWEKRRVQFSVQEAERRKSLSSLSSDQNHEQLPPPTSDMQIIADDSTPIDALFDGTIALGEFVPSSSPECLGELLDSRYMLPFILPYDNAYLVAAPPKDAAYRNLFMNPASPFISDGSKTNSRPPSRSSFSSSRPMGWHLPKQTKLRELPLDFFGWLKERETDHKLNRDAWEFKNKRMSSVHTDLKVDRDTGFEGLPIPNRIQRNNSQHGEKSPTPTPTRPVPLVDKIKINQSTDLQGLLPSLTEDNDKTPIKESERIKYPLGEDLPNSNSNHIIKSSKSIQELRESSKLISSPTFEIISNKIEHNRSESFELKLRMQGNINNIIGETYKSPFISSSIKSPTLSQFSEETSISNLSNNSSNELGGKKKWWKLGKKLSSLNLRGEEFDFDKRKFRDSSEDTISPGNGLNNLEMREEIRTPIKSPESGYDREKRGFWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I1F9</accession>
    <name>A0A1B9I1F9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_04987</name>
        <name evidence="7" type="ORF">I206_106162</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
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        <property type="protein sequence ID" value="OCF49298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Chromosome 8"/>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="conserved c-terminal region of ge- 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EDC4-like"/>
    </dbReference>
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        <property type="entry name" value="EDC4_C_sf"/>
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    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15598">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15598:SF5">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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            <end position="295"/>
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            <begin position="22"/>
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            <end position="48"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I202</accession>
    <name>A0A1B9I202_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_04069</name>
        <name evidence="11" type="ORF">I206_104353</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
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        <property type="protein sequence ID" value="OCF49547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="KH-II_40S_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal protein S3, C-terminal domain"/>
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    </dbReference>
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        <property type="entry name" value="KH_dom-like_a/b"/>
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        <property type="entry name" value="KH_dom_type_2"/>
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    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057258">
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    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_uS3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_uS3_CS"/>
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        <property type="entry name" value="Ribosomal_uS3_euk/arc"/>
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        <property type="entry name" value="PRK04191.1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="uS3_euk_arch"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760:SF32">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="9">
        <location>
            <begin position="23"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="217"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="217"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="241"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF49547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC70403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="254" mass="28345" checksum="4B899409DE1300DF" modified="2016-11-02" version="1">MSSSQQISKKRKFVADGVFQAELNEFFTRELAEEGYSGCEVRVTHARTEIIIRATHTQDVLGEKGRRIRELKALVEKRFKFPENSLELYAEKVQFRGLSAVAQAESLRYKLLGGLAMRRACYGVLRFVMESGAKGCEVVVSGKLRAARAKSMKFTDGFMVHSGQPAADYIDYAVRHVLLRQGVLGIKVKIMKPFDPEGRQGPSKNLPDVINMVEPKAEGAIEIRSEHKEPQVQAIPPPQAQQPQEAQPAAEGQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I249</accession>
    <name>A0A1B9I249_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_04097</name>
        <name evidence="12" type="ORF">I206_104325</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transient receptor potential (TRP) ion channel family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010794.1">
        <property type="nucleotide sequence ID" value="XM_019155836.1"/>
    </dbReference>
    <dbReference type="STRING" id="1296096.A0A1B9I249"/>
    <dbReference type="GeneID" id="30172466"/>
    <dbReference type="KEGG" id="kpin:30172466"/>
    <dbReference type="OrthoDB" id="5312224at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032800">
        <property type="entry name" value="TRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF6">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01320">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628350" evidence="9">
        <location>
            <begin position="18"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="504"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="545"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="597"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="621"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="656"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="684"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="domain" description="ML-like" evidence="10">
        <location>
            <begin position="17"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="427"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="822"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="871"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="916"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1165"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="832"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="875"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="967"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="981"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1058"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1073"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1117"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1187"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1214"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1296"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1333"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1353"/>
            <end position="1366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
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            <dbReference type="EMBL" id="OCF49575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC70375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1366" mass="147451" checksum="6E28FDC88B4A3D82" modified="2016-11-02" version="1">MLRYLYTILIIATCSLATPLQAKFSSCLSQYSPVAAGQNRMNITDVYAEIIPREEANQLGLAADGHRVLRVNLIGVVGSEVSGYDNVTNKLATLFTNTKAATWNVYQSTSWLCNSVFPSELPTPYFPYNTTYCPLPAGDFAINLTIPLYSSYALTTIQTEVRIVDTSTEAANLACIDIQVSPYNRKGWYYKLFLWIPVATAIGFWLVSWGARFVTGWIVGSGVAEYDQKESTALKTGGVGGPNKKEAKLRKWGTMIISGLSGERLSVSGGLLRFSTPSLKDILFHVQFCTMLGMIAVNWPEFAYPIFARGAWADLVWNTTLVQGSDADHKRVATYPFNYTPPSPFASQMNDAQYPLYLDSNLFNPLFDSHNASNGMESFATAVGLRPQDLFGTCLTIFLLLTAAVMLISLSVWFLHGLFEYLSTGSSTLQRGSPGPKRASLGSSPRGSFGGKEAYDPSRNPSLWSDGPNSLPTRASLAQQAKINSPSPLRRIWFRFKLKGEAGAFHAAALYGNLIRLILIFHLPITAFSLYQLTLANRASIVSRVFAALAFAFISVIIPAFILYRISRTASGKLYDATRTLLSLGPMYNIYVENKQMYRVVPLTASLIVGIVIGAGQKSGIAQAIIVILVELAMLIIPGVWYPWGEGASMGASNAFLGILRLISAVLVMLLSSTIALSSPTTDWIAYAILILQAITFIFFLLMLITKIIEGSVRLAGGVHFDESTHPLDGGIFAAIMDLDCLNGVRGGKAAARKRRKRGSRQLQRNVSAAGSLTTQMMLDRHSQGVSRPPVASSSDLITPFLTPGHPQMAMQERPSYFPNYNAPPLGPPPPEAERLSSESRSAEGHGENIMDAWQPSATLSTSSGYAPPGAFVPSVNSPTRNLYGQVPTSTPPPTNGAPHRSFSVVRGGRADFENPYEVLAGPGERRQSLNSGMGDHTPKIRVSQVSHRPMSPPHNRQQSSTAIIELATPLASPLLPTASNATPGPSRQPQGIRPNNAGLKPPALAIPKRRSLNDLKNDPSPDSQYSSSTVKKQKHKKNKSSVGWFTRSSNDKRGGSDDESDELPSDDEPGPSKRKTAKAKARRRSNLPGTEGFREPLPFEDIPLSPEQEEWRNTKGAGSSGIAGIFGRKKKKSQLDEEIASQARDENKARKAVLAAESGALFAGVDAPTTSPNGKKGFIVKRPGLSPTSPTSASSSNTNYAQASSSFKVRRINQPTPLPQVTKTPNENEYVSSVHPSPNMGTISTINGSSGHTSMNGTPPNGSNENTPLSSSNGGNGGSKGFRVIRPPKFGINDPNPTTSQSTTTKNEQSSNVQMGYPPTAFVPISSTSSQNPNRISTTSSNSTNGLTPGRPVRDPRRSSGESQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I279</accession>
    <name>A0A1B9I279_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SURP motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_04149</name>
        <name evidence="3" type="ORF">I206_104275</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">CBS 10737</strain>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="OCF49627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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</entry>
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    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
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                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
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    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:metalloendopeptidase activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Mito/Outer_Membr_Metalloprot"/>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
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        </lineage>
    </organism>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 [3Fe-4S](0)-[protein] + 2 Fe(2+)-[Dph3] + NADH = 2 [4Fe-4S](1+)-[protein] + 2 [Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71239"/>
            <dbReference type="Rhea" id="RHEA-COMP:17997"/>
            <dbReference type="Rhea" id="RHEA-COMP:17998"/>
            <dbReference type="Rhea" id="RHEA-COMP:18001"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:33723"/>
            <dbReference type="ChEBI" id="CHEBI:47402"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[3Fe-4S](1+)-[protein] + Fe(2+)-[Dph3] = [3Fe-4S](0)-[protein] + Fe(3+)-[Dph3]</text>
            <dbReference type="Rhea" id="RHEA:71235"/>
            <dbReference type="Rhea" id="RHEA-COMP:17996"/>
            <dbReference type="Rhea" id="RHEA-COMP:17997"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:33751"/>
            <dbReference type="ChEBI" id="CHEBI:47402"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DPH3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011029.1">
        <property type="nucleotide sequence ID" value="XM_019156071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I2M5"/>
    <dbReference type="STRING" id="1296096.A0A1B9I2M5"/>
    <dbReference type="GeneID" id="30172706"/>
    <dbReference type="KEGG" id="kpin:30172706"/>
    <dbReference type="OrthoDB" id="66964at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.660.10:FF:000001">
        <property type="entry name" value="Diphthamide biosynthesis 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.660.10">
        <property type="entry name" value="DPH Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044248">
        <property type="entry name" value="DPH3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007872">
        <property type="entry name" value="DPH_MB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036671">
        <property type="entry name" value="DPH_MB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454:SF31">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454">
        <property type="entry name" value="DPH3 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05207">
        <property type="entry name" value="Zn_ribbon_CSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144217">
        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51074">
        <property type="entry name" value="DPH_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DPH-type MB" evidence="10">
        <location>
            <begin position="4"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="69"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCF49810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC70139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="140" mass="16056" checksum="FC0172A052E22219" modified="2016-11-02" version="1">MPNYYDELEIEDFAWDPVAKLFHYPCPCGDRFEISKGQLRDGEEIAICPSCSLIVRVVYDYLDWEDYVTSDEEEDDAESLETPPTETSNEEPAVVDNKEDSKGEDSRQQGKEEKADEADPDIIKVLDRLDLKDNKQEGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I3R5</accession>
    <name>A0A1B9I3R5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Succinate dehydrogenase assembly factor 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_03494</name>
        <name evidence="5" type="ORF">I206_105606</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SDHAF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011394.1">
        <property type="nucleotide sequence ID" value="XM_019155240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I3R5"/>
    <dbReference type="STRING" id="1296096.A0A1B9I3R5"/>
    <dbReference type="GeneID" id="30171863"/>
    <dbReference type="KEGG" id="kpin:30171863"/>
    <dbReference type="OrthoDB" id="201362at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012875">
        <property type="entry name" value="SDHF4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28524">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28524:SF3">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07896">
        <property type="entry name" value="DUF1674"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="83"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF50175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC71648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="129" mass="14379" checksum="50F176DB414531D4" modified="2016-11-02" version="1">MSMIRSNFSSIQFLRIPMRSIFTSTQKLTKKIPSFNKPGPPQLPASDQAEFEALIKLNQSIGASPKITESENPSKLIEELKQHKDIRKGPKPDFIGEINPKTGEMGGPKTDPFKAGDQDWSYAGRVTDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I417</accession>
    <name>A0A1B9I417_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Asl1-like glycosyl hydrolase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_03591</name>
        <name evidence="4" type="ORF">I206_105506</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
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                <person name="Hansen M."/>
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                <person name="Imamovic A."/>
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                <person name="Sykes S."/>
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            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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                <person name="Heitman J."/>
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                <person name="Young S.K."/>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Berlin A.M."/>
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                <person name="Griggs A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
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                <person name="Zeng Q."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Nusbaum C."/>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011629.1">
        <property type="nucleotide sequence ID" value="XM_019155475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I4G5"/>
    <dbReference type="STRING" id="1296096.A0A1B9I4G5"/>
    <dbReference type="GeneID" id="30172101"/>
    <dbReference type="KEGG" id="kpin:30172101"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000281">
        <property type="entry name" value="Uncharacterized oxidoreductase YIR035C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF8">
        <property type="entry name" value="BENZIL REDUCTASE ((S)-BENZOIN FORMING) IRC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF50410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC71404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="254" mass="27440" checksum="3F86F9126B29F2D8" modified="2016-11-02" version="1">MSKSPVVILTGASRGLGLAVLRILLSKHNARVTTLSRSISTELQSIVKEYGQDRILPIQGDVGISEDNIRAVDETSKKWGQIDGLILNAGSIEPKRIDSVPIESLTSYVQTNLLSTIYLVQPALPYLRKTKGKVVLISSGASTSGYQAWGLYSLAKAGMNSLARTLAAEEKDNGIAVFAIRPGMVNMQALLRNDGPATMHPDEMIKFQNAYEKGELLAPEQPGSIIAGLAISGPQELSGEYINWADERLKSFSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I4G9</accession>
    <name>A0A1B9I4G9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ATP-binding cassette transporter YOR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I206_03741</name>
        <name evidence="15" type="ORF">I206_105349</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011638.1">
        <property type="nucleotide sequence ID" value="XM_019155484.1"/>
    </dbReference>
    <dbReference type="STRING" id="1296096.A0A1B9I4G9"/>
    <dbReference type="GeneID" id="30172110"/>
    <dbReference type="KEGG" id="kpin:30172110"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18597">
        <property type="entry name" value="ABC_6TM_YOR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18606">
        <property type="entry name" value="ABC_6TM_YOR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000565">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000061">
        <property type="entry name" value="ATP-binding cassette transporter YOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000010">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0843">Virulence</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="475"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="962"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="999"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1102"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1185"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="251"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="674"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="967"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1279"/>
            <end position="1529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="600"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCF50419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WWC71394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1545" mass="171638" checksum="96E12F7915CA83C4" modified="2016-11-02" version="1">MSPSTPTVRDPSPSTPSDAVAPSSHSISTRVGAEDDQELRKKISQANTIDEKIGDPSSKEYDERGIHEIEEEGQKRKVMVVMEQRTGKEILKDVGGGPYTQPRWRHSLPFVKPKHPPPPPPLSLDDAKVTPEVTANFFDKLFFNWISPMMALGSARPLQETDLWKMDDARSAKGLAEKLRISYADRTKKANEYNARLSDPNTPLPFSKRMTYPLMPNRQKREKEYREKHGKKHASLALALNDVFGWYFMSAGVIKLFGDVCQAVTPLLIRSLIKWSTNWQLAEVTGQPKPKIGNGVGMAIGLLLLLVTSSLSIHHYFVRSMGVGVMSRAALISGIYQQALLFTQKSRGEIPNGKLVNHISTDTSRIDFAAGFAHIIWTAPIQMIVIIIILLVQIGYSALPGIAFLLIMTPLQVMFMKNLFLIRKKAMRWTDKRAKLLQEMLGGMRIVKYMAWETPFLNKVHQIRGMEIKYIRSLLVFRSGMMAFAMSLPTLAAILSFITYSATSHNLQAATIFTVITLFQLMRMPLMMWPMTLSAVADAVNALGRLEAVFDAELITETLKIDRSQEEAVIVEHASFTWDAAPIEDDDGMMKKLQGRYGKTLGGPAVSGQKGTAEKTKADKPKKKKRMFWNKKTKKITAVDEIEAEMASGGPHDAEAGAQAVGQGAPFEVAAMNEKNEDGSHVPEQKIFQLHDIDLAIPKGSLTAIVGAIGSGKSSLLQGLMGEMRKTEGKVTFSGSTSLCAQSPWIQNATVRENILFGQPWNEERYWAAIRDACLEPDLELLEDGDGTEIGEKGINLSGGQKQRVNIARAIYFNSDIIALDDPLSALDAGVGKALFFNAIIGALNSKTRILVTHALHFLPYVDNIIMMEDGHIGEMGTFNELKARNGAFARLIREFGNEEQHDVALETEAEAMNSSGPTHTYDRTKMVAKGTAHTLMQAEERNTGALKKGTYLQYLKAGNGVFMVPILLVAISFAQATYVITSYWLVWWQEYKWDYGNGFYMGIYAGLGIMTAITMFFQGFSNALINYFASVKIHKNAITRVMFAPQSFFDTTPLGRIMNRFSKDTDTIDNTLSDAMRMAIGTLSNIVGATILLAIVEPYFLIAMAVVSLLYVHNAAFYRRSSREFKRIDSILRSSLYSHFSESLSGVATIRSYGESDRFFRDNVYRMDVENRAYYLTIINQRWLGLRLDFLGSLLSFSVAIIVVCSHKVSAASGGLGLSTIITVQQSFSWLVRQIAEVENDMVGAERIMHYANELDQEAPHQIKEVQPPPTWPDEGKIEFNNVKMRYRDELPDVLKGLTLNVGANEKIGVVGRTGAGKSSIMVALFRMAELSGGSIKIDGIDVSKIGLNDLRSGISIIPQDPLLFSGTLRSNIDPFNTKNDIELYDTLRRAHLISNTPRPSTSNRLSMSNNESNSKRFSLDTLIEEEGGNLSVGERSLVSLARALVRNTKVLILDEATASVDVETDSKIQQTIRNEFKDKTLLCIAHRLKTILSYDRILVMADGKVEEFDTPENLFLKNGIFTEMCGKASLSLGDIRAAAALRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I6A9</accession>
    <name>A0A1B9I6A9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_03135</name>
        <name evidence="3" type="ORF">I206_102780</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF51069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012288.1">
        <property type="nucleotide sequence ID" value="XM_019154885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I6A9"/>
    <dbReference type="GeneID" id="30171504"/>
    <dbReference type="KEGG" id="kpin:30171504"/>
    <dbReference type="OrthoDB" id="2579508at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF51069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC68844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="341" mass="38133" checksum="DEAF02F4676F1824" modified="2016-11-02" version="1">MPQPPLDLNKYLSKSLPHLREQYPPGTGGTGARAEFEGDLKGVQVIENFDDEVTKYFKTLPSEPITPHPHYKYPKFVAALNTIPNPLKTPSDLQKALSSIPLLATSSVLTALDSDPEDFKFVTDAQALDRAGYESDGGVDGSGESKPLKPDYKTKPWTFKYSKSPLGSGEFLLTKGGSDDVKLVVRTINSSAFTSADWKEYIVTGPYKYNIRSKASWYWSRSYKAAKRLNCQYYILTDWQRWTFGYFNEDRTHGWTSPILEYNAENPGVLQALLFWTRSAIGAENGFKPIQKDVSSLPELFPANPARRISATGNTHNPRDQTKPRLANESDIEESDAEDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I6D6</accession>
    <name>A0A1B9I6D6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Translation initiation factor eIF-1A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_03150</name>
        <name evidence="6" type="ORF">I206_102796</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-1A family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF51084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012303.1">
        <property type="nucleotide sequence ID" value="XM_019154900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I6D6"/>
    <dbReference type="STRING" id="1296096.A0A1B9I6D6"/>
    <dbReference type="GeneID" id="30171519"/>
    <dbReference type="KEGG" id="kpin:30171519"/>
    <dbReference type="OrthoDB" id="274995at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05793">
        <property type="entry name" value="S1_IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00216">
        <property type="entry name" value="aIF_1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00523">
        <property type="entry name" value="eIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21668">
        <property type="entry name" value="EIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1-like" evidence="4">
        <location>
            <begin position="22"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
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                <person name="Young S.K."/>
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                <person name="Litvintseva A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="David-Palma M."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Young S.K."/>
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                <person name="Gargeya S."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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                <person name="Heitman J."/>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012505.1">
        <property type="nucleotide sequence ID" value="XM_019153765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I712"/>
    <dbReference type="GeneID" id="30170369"/>
    <dbReference type="KEGG" id="kpin:30170369"/>
    <dbReference type="OrthoDB" id="10669130at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF51286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC70519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1135" mass="129939" checksum="0A03AF23BC303E9C" modified="2016-11-02" version="1">MPPKVTLRKRKPPQQATQDGGDKKRKKDTGESRSKKADPEEEEDDAEDDDDGVKRNEKEARDGDKHTLPGSKRRLQVELAGNVTQRGDNKPDVVTQSMMTPEKSGRSNLPLNLHVPFLGREFKLPVFDKTSGNHLSKVELLYNMVLSSPKGVSFESIWRRLCDLEQDRDVVTKYISARIETFKMAYSEKMQDISDEIQQELVDGLLTVLEDFKRTVDGSQSHKNHLLTSCISKMMVRLLLTDEDLKNPFYNSLRSDDSSRPGVPSEKFRDSLDELESMTLTKTIKALFIEYSTSQATIDQTQDDRSELVGDVQEKLLYPCTIVGMETVVPDRFLKEYRASEEGDLDKAGIDPEERQDSFTRRMLYDMKVKFQPESTLGDGWRTLMKITDQSTIAQTFFSAKESLCAGLDFKFRKIPIEQQNCSTLLSKVYEDDPQQADLDEPKDQRTVIVETLTGVLDQINTSGSLENIHRLPLEIAVRHLGEDRVNYQMGNDPLFCSINTMFAARNGTRTGTEAISFLISLELQALAVSIRLCKIRSSGGETGEYDTILRQIQNYQRPVLAAAHTVETVTHGVPPPATPPPQLVKSKKPKGKHTARHTKVKRFIGPVFDLNSTTPPGTGKNLVYFSRYKRRCETMLRAQIKPELTISTYIREMMKIGTDPQVVAKAYVKARIVVFKHYKYDLKFEIPLEVQQDVIESLAEALEEFHNTHPTRSTTSPTPPFEIALSNLKKDDKIPETILARVFFSSVNIDPSEGVWLPKVSLDQIPVVIHYHELETLATATRMLRNKRERDAAGIEEDDIYWQEILDDIELFSDKEAKAERLAEDEGMRAQVRKLRKLTLLSSFSTNLFENSSVEFNNLGLTYQKGYTLDEIWQSIKQSRPDSNLHWNDIATVYLCCRFAVYKREFPDDNMNIAVKDIEFLVETLTKELFGYNHDRQYCLPFEQCVTVEVYEGNLNQKTLKTTMIKSVGDDEPLLPGIPEDQVLPTLVRLEFETMALLEHLLEDYKSCSKLSADLDILSTPEERQKTHDGMQSLLDEIAGKDNHFELRAWRLPQLFTDEQMEQAQEDSFNQRKKRDGRLVQDADAWKHRPRLIQRAGAAREKLWTTKGQREVLLERAMKNERVYENDDCFTDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I750</accession>
    <name>A0A1B9I750_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_02084</name>
        <name evidence="5" type="ORF">I206_104550</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012589.1">
        <property type="nucleotide sequence ID" value="XM_019153849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I750"/>
    <dbReference type="STRING" id="1296096.A0A1B9I750"/>
    <dbReference type="GeneID" id="30170453"/>
    <dbReference type="KEGG" id="kpin:30170453"/>
    <dbReference type="OrthoDB" id="79452at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060237">
        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051025">
        <property type="entry name" value="RhoGAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228:SF25">
        <property type="entry name" value="F-BAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228">
        <property type="entry name" value="SPERMATHECAL PHYSIOLOGY VARIANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="355"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="646"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="816"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="474"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="679"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="691"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="712"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF51370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC70599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1031" mass="113028" checksum="48297E71B7660500" modified="2016-11-02" version="1">MSPSRIPRPGGIGSPTITTSPLSQSSVTTRSTPALGTVVHLSKNPFAQLHNIKQQQQQHQQQQIQNESPTPSVGSTNNTLGVGIKGQSINGKRRIKPPSSPDLDDSKDFSTNNIRRSSPLDVKGRIPSNGKSSIIPGQRIIMRQPSTPTLINNQKSPIPLGRQRALSSTLSNKPIIINKNNYNSNLQVKENLIVIIPKIKDKEKEKKSYESNSLENREPTVPKHIKIRLKLLHQLGILLGIDSIEISEKIDIPGLLARVDQSYERDKERFENFNSFNNSNEIKNGIGIGNGNGNDQINLKGNLISGGGQSNKGVFGMFKRLGGSSNNRKGDENLGSDRLNVPQEGPAFGVPLCEAPLGSWCTSLIGGQKHELPLVVFTIVEEIYRRGMSQPGIFRLAGDGIRISHLTKVYNLPPLYGDSLPINQEPIHNLTGLVKRYVRDLPEPILDESLFPAFLAFCVDKKDDSSLTKDTEIQTENSISNDETKSNQQKSRSLINDIDQLPLETRIIAAQILLKLLPPLQFSLFIYLLAFLAQLPLFSDNRLNIESISIIFGPAMCAARGKGISGLGPTVSSNSTSVNNSNTIGGGIRRGIYNHNTFDPDMISDLVSKSQNVLSWLLKNWSSISEKVLEDDDSLISSLSNNITQPQDELKEKKNKKGKQIIDPRLLSPIDLRGSNDGMRARKPDSTKDFNINNESPNSSPIISSTASQLDNEDRNKSPIEPDIKTPHTTIQLGLGLRKSSSSHTLRMNSSGGTKYSISTSSGFGGMKSSPSSGGLFARALSSMSISSQAGNEDKLGKGPKRSASFTSLSSLVKKVGKDNKHVPPLPGRSMSDDRDNARSTVNPQITTVLGSLHDLLVSKDKQIERDAKELALLRHTLLEMDEKLQKSTLSSFLPGPIGINGCVCSIHPNSNISKQEIMPEIKITSTPSNSTIPTSISFKQNENEINELQIQLKTSLASLETCRLNLHKQNEKILIIESKNSRLESEKKLEISKLQVALALEQARCVGLIEERDLARDRLEKVKTTLFSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I7J7</accession>
    <name>A0A1B9I7J7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_02256</name>
        <name evidence="3" type="ORF">I206_104718</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 10737</strain>
        </source>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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        </source>
    </reference>
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</entry>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="8" key="3">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 Fe(II)-[cytochrome c] + H2O2 + 2 H(+) = 2 Fe(III)-[cytochrome c] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:16581"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.11.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="13"/>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012811.1">
        <property type="nucleotide sequence ID" value="XM_019154071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I7P4"/>
    <dbReference type="STRING" id="1296096.A0A1B9I7P4"/>
    <dbReference type="GeneID" id="30170676"/>
    <dbReference type="KEGG" id="kpin:30170676"/>
    <dbReference type="OrthoDB" id="2859658at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004130">
        <property type="term" value="F:cytochrome-c peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00691">
        <property type="entry name" value="ascorbate_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000009">
        <property type="entry name" value="Ascorbate peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000005">
        <property type="entry name" value="Cytochrome c peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002207">
        <property type="entry name" value="Peroxidase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF58">
        <property type="entry name" value="CYTOCHROME C PEROXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00459">
        <property type="entry name" value="ASPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 13 15" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="14">
        <location>
            <begin position="95"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCF51592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="WWC70817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="374" mass="41495" checksum="1132DEA2AC3C6ECA" modified="2016-11-02" version="1">MSLRTPMLRTACARRAGQSVNLRTQVIKRRFASGGPEITPPPPPRSSSVPYLLAGVGLAAAGAAYLFYGTDGTPRETAKEIGSEARGLAAAAEGKLGLRHKQEDYQKVYDKIADTLEKEGYDDGSLAPVLIRLAWHASGTYNKEDNSGGSNYATMRFKPESEHGANNGLNVARDHMQKIKEEFPWISYGDLWTLGGVAAVQESGGPTVPWRPGRIDGFEHHVTPDGRLPDAAQAQDHLRFIFYRMGFNDQEIVALSGAHAMGRCHTDRSGFDGPWTFSPVTFSNQYFTLLQDEPWQWRKWKGPAQYEDKKTKTLMMLPTDMALVKDKSFKKFVDVYAKDEEAFFKDFSQAFAKLLELGVPTAQFAGDAWKMGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I7T7</accession>
    <name>A0A1B9I7T7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_02263</name>
        <name evidence="3" type="ORF">I206_104725</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012768.1">
        <property type="nucleotide sequence ID" value="XM_019154028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I7T7"/>
    <dbReference type="GeneID" id="30170632"/>
    <dbReference type="KEGG" id="kpin:30170632"/>
    <dbReference type="OrthoDB" id="10378791at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF51549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC70774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="79" mass="8668" checksum="CD0E48F90445ADAB" modified="2016-11-02" version="1">MNEQKISNTNANENTYINSEPITTEPIKGIKKPVIKPFIDKPPNGEGTRNKPLGSEELGNPIGCGPDHFGKWLMACSRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I7U1</accession>
    <name>A0A1B9I7U1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calpain catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_02367</name>
        <name evidence="5" type="ORF">I206_104828</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012871.1">
        <property type="nucleotide sequence ID" value="XM_019154131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I7U1"/>
    <dbReference type="STRING" id="1296096.A0A1B9I7U1"/>
    <dbReference type="GeneID" id="30170736"/>
    <dbReference type="KEGG" id="kpin:30170736"/>
    <dbReference type="OrthoDB" id="424753at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0788">Thiol protease</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628419" description="Calpain catalytic domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Calpain catalytic" evidence="3">
        <location>
            <begin position="38"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF51652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC70876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="264" mass="28843" checksum="1411FA0DA9B9BFD4" modified="2016-11-02" version="1">MFLGTTTFVICTLASTILAGPIAKPVGILPGQEEASKDLIAEPLWSKDGPVLTDILQGPDGECWFQAGLISLVKCNQHAITNIVKDTGIGKGENGADTDKAEVKLYTKDYELKVFEVKHQSSIGGTVGELPTWWPAAMKRAAMKMGGYKGLHENSIGAGFPSDALKMLTGKKTMILDSGSFDKVQIWSWIQHSNDTPMIITTKSKTSKLVKGHAYVIMSYGGDGPENATLRLRNPWEGITWHDLDEIYKDISQISTLDEFRSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I829</accession>
    <name>A0A1B9I829_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Aconitate hydratase, mitochondrial</fullName>
            <shortName evidence="13">Aconitase</shortName>
            <ecNumber evidence="13">4.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I206_02306</name>
        <name evidence="17" type="ORF">I206_104768</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.-" evidence="13"/>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012810.1">
        <property type="nucleotide sequence ID" value="XM_019154070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I829"/>
    <dbReference type="STRING" id="1296096.A0A1B9I829"/>
    <dbReference type="GeneID" id="30170675"/>
    <dbReference type="KEGG" id="kpin:30170675"/>
    <dbReference type="OrthoDB" id="2224430at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01584">
        <property type="entry name" value="AcnA_Mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000003">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000004">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1060.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="entry name" value="Aconitase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005558">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
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    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0408">Iron</keyword>
    <keyword evidence="9 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="14">
        <location>
            <begin position="71"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="15">
        <location>
            <begin position="587"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00015940"/>
        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="RuleBase" id="RU362107"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="OCF51591.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC70816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="788" mass="85057" checksum="9A9D10D0D00E95E9" modified="2016-11-02" version="1">MSSRFLVKGAQSLSSRSSMLSRSMATVQSSIGDKQVPMSNLEKGKFVNYARIESNLQIVRQRLNRPLTLAEKIVYGHLDNPHEQDIERGVSYLKLRPDRVACQDATAQMAILQFMSAGLPQTAVPTSVHCDHLIQAQVGGPKDLARAIDINREVYDFLATACAKYGIGFWKPGSGIIHQIILENYALPGLMMIGTDSHTPNAGGLGMVACGVGGADAVDVMAGIPWELKAPKVIGVYLDGKMSGWTTPKDIILKVAGILTVKGGTGAIIEYHGPGVESLSCTGMATICNMGAEIGATTSLFPYNKRMAAYLEATGRSQQAAYAQEFNHNLQPDEGSEYDRRIEINLNELEPHINGPFTPDLATPISKFAEEVKKNNWPEELKVGLIGSCTNSSYEDMSRSAHIAKEAADHGLKTKSIFTITPGSEQVRATIARDGFVDTFEDVGGVVLANACGPCIGQWDRQDVKKGEVNSIISSYNRNFTGRNDANPATHAFVASPDLVTAMTFAGSLTFNPLTDSLKGADGKEFKFSDPAGFELPAKGYDAGENTFQAPPEDGTTVNVAVSPTSDRLQLLKPFKPWDGKDIVDAPVLIKAKGKCTTDHISAGGPWLKYRGHLENISQNCLIGAINADSGEANSVLNQETGEFGPVPTVGAYYRDRDIPWVVVGDENYGEGSSREHAALEPRFLGGRAVICRSFARIHETNLKKQGMLPLWFKNTADYDKISGTDKLSIVGLNEFKPGQDIKVEITHKDGSKDSFLTTSSINEGQWEWFVAGSALNKMAAAAKARGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I8B3</accession>
    <name>A0A1B9I8B3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome complex subunit SEM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_02514</name>
        <name evidence="5" type="ORF">I206_104975</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DSS1/SEM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC71022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013017.1">
        <property type="nucleotide sequence ID" value="XM_019154277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I8B3"/>
    <dbReference type="STRING" id="1296096.A0A1B9I8B3"/>
    <dbReference type="GeneID" id="30170883"/>
    <dbReference type="KEGG" id="kpin:30170883"/>
    <dbReference type="OrthoDB" id="5586203at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007834">
        <property type="entry name" value="DSS1_SEM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771">
        <property type="entry name" value="26 PROTEASOME COMPLEX SUBUNIT DSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771:SF0">
        <property type="entry name" value="26S PROTEASOME COMPLEX SUBUNIT SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05160">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01385">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF51798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC71022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="109" mass="12059" checksum="387A4D4FF3CE3CA8" modified="2016-11-02" version="1">MTDKQQPTDTKQENATAGPSNGNGEGIQPTEKKTLPKLGALEDDDEFEDFPATDYGGNVLDALKKAGDGPNDNLWEDNWDDDDIEDDFTKQLRTAIQEKQGVPDETMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I8G2</accession>
    <name>A0A1B9I8G2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_02584</name>
        <name evidence="10" type="ORF">I206_105044</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
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        </source>
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    </evidence>
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</entry>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
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    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
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            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="OCF51795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">CBS 10737</strain>
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    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat STRAP family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF51995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013214.1">
        <property type="nucleotide sequence ID" value="XM_019153053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I906"/>
    <dbReference type="STRING" id="1296096.A0A1B9I906"/>
    <dbReference type="GeneID" id="30169648"/>
    <dbReference type="KEGG" id="kpin:30169648"/>
    <dbReference type="OrthoDB" id="408728at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF13">
        <property type="entry name" value="SERINE-THREONINE KINASE RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="81"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="300"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCF51995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC69777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="346" mass="37426" checksum="4A1B796A580EDE19" modified="2016-11-02" version="1">MSYSNGYNSNPHSHSSTPAPGDSNGNSAVKVQPLLCSGHTRPVTHLSFSNLLDDGTYLLISACKDGNPMLRSWLGDWIGTFLGHKGAVWSSKISLDTSKAVTGSADFTAKIWDCNSGEALHTFSHNHIVRSVALNPQQTPQYLLTGGHEKKIRLFDLGRPDAEPLILGSRPDGLSTDGIVRSLVWDEGSGGTMGVSASEDGLVRWWDLRTLSQTAQLDLGESISSMELAHGGGTLSVTAGKKVHFLDILRQHPPVTVELPHPPTSASLHPFARDRFVVGSTNDPWVRVYDLDSGKEKEVYKGHHGPVLCASYSPDGEVYASGSEDGTIRLWQTNPGKSYGLWQTQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I912</accession>
    <name>A0A1B9I912_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nuclear cap-binding protein subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_01352</name>
        <name evidence="6" type="ORF">I206_103645</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013287.1">
        <property type="nucleotide sequence ID" value="XM_019153126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I912"/>
    <dbReference type="STRING" id="1296096.A0A1B9I912"/>
    <dbReference type="GeneID" id="30169721"/>
    <dbReference type="KEGG" id="kpin:30169721"/>
    <dbReference type="OrthoDB" id="10252707at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000063">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.20, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027159">
        <property type="entry name" value="CBP80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015172">
        <property type="entry name" value="MIF4G-like_typ-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015174">
        <property type="entry name" value="MIF4G-like_typ-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12412">
        <property type="entry name" value="CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12412:SF2">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09088">
        <property type="entry name" value="MIF4G_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09090">
        <property type="entry name" value="MIF4G_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G-like type 1" evidence="3">
        <location>
            <begin position="384"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G-like type 2" evidence="4">
        <location>
            <begin position="593"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="21"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="748"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF52068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC69702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="921" mass="102674" checksum="37044CAA58453085" modified="2016-11-02" version="1">MNFSQNGFNPMMGFANPYAQAFGSPQNYGSPQRGYGGRGRGRDDRRGGRGRGGGGGGGGGGGGGGRDRPPIPENSNARMRKMVIKLGDDENFEPVEDSHRLARVLKRGWGEGSAGVCEGFRISVTQQPHKHSYLVVLLLSLSRRHVTTAEGAGEDAQLGDKRKAEDEDDIECGKEILEDLSRALRGWVEGREWQNVRLGLQFFSLLVPAGLVTSSSLLGVYKSLLAVLEEVGGGGDRAERAVRAVGEGLIRSGKSLYDESPDEVEGLITSIEGYIIGRRNEIKSLVDPLSPILANAEANAPNPDTLDDFLSALHALRANFFNPPACLSRHWELYTKDEETIQADPFELSPISMPPEMYAVDAYELDKGEGRLGNIVLFADDVVPPPETLEGWVLRSLTLDLINIYEVNRKECASLLISLRRYLPQNTFKPVNPPAEEEDASTLSTWSAESLVISTLLNGLLTLPRSAYKSIYYGSVITELCKLSPNTIAPPVGRAVRKIFGYLGNDGLDVEITRRVAEWFSVHLSNFGFQWMWKEWVPELELPASHPKRAFMRRVAELEVRLAYYDRILDTLPEAMKAEGAGVLASEPPEPVWAYEKPDHPLHAEAKELLQLFRSKATTSDIRLHLDNLPGSEEGISANVRKMVFETLFQLGSRSFSHFLNATERYIDTLRYLTSDQASRKVLLSAVWDYWKYSHQQKLITVDKYLQYGILEGLDVVEYLFEEDGDTEGEEGDGWTDEWKWEILKMTIEKHSGRVQAIKNRMKVIEREDESARARRAAEILEKGGDVGEGEDEDLTDIRPEGSKAFNDAQTSLDIQSTRLEKILISTMKQFISSLLPNEIAANQGLKGVLTLLQSGESALWSVRAKWGWYREFVRLYSAQLLPLAEPIENSIFSTLPSGDDDIERRAVEMVRGVWSSSLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I975</accession>
    <name>A0A1B9I975_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphodiesterase</fullName>
            <ecNumber evidence="3">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_01374</name>
        <name evidence="7" type="ORF">I206_103624</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
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        <cofactor evidence="3">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="3">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
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        <text evidence="3">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
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        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
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        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
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        <property type="entry name" value="PDEase_catalytic_dom"/>
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        <property type="entry name" value="PDEase_CS"/>
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        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
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        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="HDc"/>
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        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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            <end position="1066"/>
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    <feature type="region of interest" description="Disordered" evidence="4">
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    <evidence type="ECO:0000256" key="4">
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I9E6</accession>
    <name>A0A1B9I9E6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">I206_01524</name>
        <name evidence="4" type="ORF">I206_103473</name>
    </gene>
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        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC69531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013457.1">
        <property type="nucleotide sequence ID" value="XM_019153296.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A1B9I9E6"/>
    <dbReference type="STRING" id="1296096.A0A1B9I9E6"/>
    <dbReference type="GeneID" id="30169893"/>
    <dbReference type="KEGG" id="kpin:30169893"/>
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        <property type="component" value="Chromosome 4"/>
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    <dbReference type="CDD" id="cd10206">
        <property type="entry name" value="ASKHA_NBD_Arp8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Actin-related protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 10737</strain>
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    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
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                <person name="Imamovic A."/>
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                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
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    </evidence>
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</entry>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">CBS 10737</strain>
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    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="McCowan C."/>
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                <person name="Pearson M."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        </source>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I9Z5</accession>
    <name>A0A1B9I9Z5_9TREE</name>
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            <authorList>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">CBS 10737</strain>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
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                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
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    </reference>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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            <dbReference type="EMBL" id="OCF52376.1"/>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1B9IA72_9TREE</name>
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            <authorList>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
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                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 10737</strain>
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    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013707.1">
        <property type="nucleotide sequence ID" value="XM_019153546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IA72"/>
    <dbReference type="STRING" id="1296096.A0A1B9IA72"/>
    <dbReference type="GeneID" id="30170147"/>
    <dbReference type="KEGG" id="kpin:30170147"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000380">
        <property type="entry name" value="Chromosome 1, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF2">
        <property type="entry name" value="FE-REGULATED PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="2">
        <location>
            <begin position="143"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF52488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC69279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="513" mass="56332" checksum="155DBEABB489D4F1" modified="2016-11-02" version="1">MNSGPLKTVVVMGVAYGGKRAADLLSKSLPSNWRLIVIDRNSHFNHLYAFPRFAVMPQHAPKAYIPYTHLFDEPESSETPLTPPTTPPATLSALDDPSSSSSDVGVITNPKSRHQFIQASIVGLTTNSVTFVRPTLDSKKQQPRSTHSPDTYGKFDGPEETIDFDYCVYALGASMPSPVNVWSEIIKTEVQNEVGEDQTENLSGTKKHGIKWMENSAEKLKKAGHVVVVGAGAMGIQFASDLKCLYPTKQVTLLHSRTRVMPRYPIEFHVSLIEELKKLGVEVVLGERVMTWPKDPEILDGKKKIVTTDHGRTFEADIVLPCTGQKPHIALMASVNPSVICPQSGRIRVHPTLQVHALPKKGGSTVEDRLNNLSLSMPPTPPPSEPSSRCSISEESSSKDLSHIFACGDCAETGAIQAGHTAYYQSEVAARNIIRLIHQREAKESKYNLEDNDKVLENYKVSHPAIKVTVGIKRGIISNAEGVKINDEGVEDLHSMVMWPGFGFKGDDIDINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IA82</accession>
    <name>A0A1B9IA82_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Potassium channel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_01795</name>
        <name evidence="13" type="ORF">I206_103200</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013724.1">
        <property type="nucleotide sequence ID" value="XM_019153563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IA82"/>
    <dbReference type="STRING" id="1296096.A0A1B9IA82"/>
    <dbReference type="GeneID" id="30170164"/>
    <dbReference type="KEGG" id="kpin:30170164"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF291">
        <property type="entry name" value="IP11374P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="418"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="239"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="371"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="490"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="754"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="813"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="491"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="511"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="544"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="567"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="621"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="656"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="758"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="818"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="839"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCF52505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC69262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="891" mass="101956" checksum="E895C547BCDBD4CE" modified="2016-11-02" version="1">MKTIKESDSNDGESLPTYKANNVGENSSKQNENSPYKGRDPRMGVPRTTTWHGYAFRKRKMRIKTFAKYCPLVSAIFAPLSTLLDIPALTQHWYAQYGTPQPDPTACLALSAIGLALNIIANMLLVMRFSAKSNWWWKHSTRWSLLCWLGKTVVAAINLIIFGILSRNSEGYTYLEGFWCAVTSIIDAGIISITLLFHYFFAFGSEIREKRKNDREGEDGQVDIRSQGKTFMLSVTAFISILAVQSLVFSRVEHWSYSDGIYFSTQVALTIGYGDFTPTTTAGKVLIFPFSVLTISQLGNEIALIIGFISSRAEARREQWRKKYEGAMHREANKIRPRANLTEEMALIHQINQREELMSQMYDLFWSALSLVTFWLIGATIFAEIEGWSYGNSIYTVMILSLTIGFGDFTPVQPAGKIVFIVYALMAVPIVTSFAVQTITGLLSTYSERGAIKEAFLAEMRRSPDAFAPHADFVLRYHESYDAMRKRLLKEEEEGEEEEEENQEEGNSDGINRDRIPEDGRTDEGTSKEEVTSQEKSNLIYDQPGDENEEQDDPSNSTYTGKKKDSKIHLDNAEKKLKDNYTRAKGIIEERQKETEDWRTAKIPHEEESSGNSTSSYDAPSDDREERRRPRQDTERTYVGDNDEETGGKDSSITRLKNEQTQDGRADKLENEERKLEIDLLKQLMRKTIQLEAEARQMLLDSMDKSVARTLLLADRNVQARDVRALKGDDTEILAIWDEESDKLKQSKIQANKDIQENEQSSSNNSTSLQQSKSQLDMLSRVRRYRNTFAEILVVGSILQKLEGEEKEKFERFRGDTLEEATDEDENNNNNNNKGFKRYKTEPTKPKSESPEEVEDIDKIAENKWDGLSSRIYKRWARKVREKDLKKWETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IA97</accession>
    <name>A0A1B9IA97_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein ERB1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Eukaryotic ribosome biogenesis protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ERB1</name>
        <name evidence="10" type="ORF">I206_01833</name>
        <name evidence="11" type="ORF">I206_103162</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat BOP1/ERB1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013761.1">
        <property type="nucleotide sequence ID" value="XM_019153600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IA97"/>
    <dbReference type="STRING" id="1296096.A0A1B9IA97"/>
    <dbReference type="GeneID" id="30170202"/>
    <dbReference type="KEGG" id="kpin:30170202"/>
    <dbReference type="OrthoDB" id="5571054at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000576">
        <property type="entry name" value="Ribosome biogenesis protein ERB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03027">
        <property type="entry name" value="BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028598">
        <property type="entry name" value="BOP1/Erb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012953">
        <property type="entry name" value="BOP1_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1 BLOCK OF PROLIFERATION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08145">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01035">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BOP1 N-terminal" evidence="9">
        <location>
            <begin position="227"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="492"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="755"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="817"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="59"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="120"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF52542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC69225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="843" mass="94773" checksum="DBE2D2301E18DBBA" modified="2016-11-02" version="1">MAPKNATASSSRVATNLKTINGKAGPSTILKNKNKKRAVQEVSEDEDDDFASVGSGIDMSDDEEVEEGEENEDEEAFPEFDSEIEDEVDQADEGDSESEELDDEEESGSESGYNSSDIEAMYDEEEDNENEDEEYSPLTSPSSSHKELSTDEKLSKLIAKNSIKPDESLGTDAKISKAKEGVGKLVPSKFVEGGYKREYEDYEAGYGSESSTEDNPNTVGNIPMEWYDDLPHIGYDVNGRKIFRPAQGDELDKFLSNTEDPAAWTSAEDRLLQQSVQLSDKELDIIRRLERAENPDADYDPYQPTIEWFTGEGNERVMPLSAAPEPKRRFVPSKWEHKKIMKIVKAIREGRIIPNKPSATKPTVYQIWSDSDQANLEHAMYMPAPQLPPPKTIESYNPPEEYLLNEEEQKEWEEAEKEDRKIDFLPSKYDSLRLVPGYKNLVQEKFERCLDLYLAPRTRKVKLNIDPESLIPKLPSPKELKPFPLATSVLYRHPENSRVRSVDTSPDGTFVATGSEDGIVRVWDLGNGREIWKWNLQSGAIQHIAWSPYKDESLLIALVAGKIAVLSPLALVAPSIAANTLNHVNTAFASSAATTKMGSGKEIKGTELIKWVRPNEKERERGVLVFIEVPGTPKQISWHRKGDYFATVASDASNKSVLIHQLSKHATQSPFKKLPGQVQKVLFHPLKPHFFVATQRYIRQYDLSSQTLIKTLQSGVKWISSLDLHNKGDNLIIGSYDKKLAWFDLDLSNKPYKTLRYHTKALRSVVYHPSLPLFASASDDGTIHIFHCTIYQDLMQNPLIVPLKILRGHKVTDGIGVLDLSWVNGKPWLVSSGSDGEVRLWCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IAB5</accession>
    <name>A0A1B9IAB5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate dehydrogenase assembly factor 3</fullName>
            <shortName evidence="6">SDH assembly factor 3</shortName>
            <shortName evidence="6">SDHAF3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_01786</name>
        <name evidence="8" type="ORF">I206_103209</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the complex I LYR family. SDHAF3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013715.1">
        <property type="nucleotide sequence ID" value="XM_019153554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IAB5"/>
    <dbReference type="STRING" id="1296096.A0A1B9IAB5"/>
    <dbReference type="GeneID" id="30170155"/>
    <dbReference type="KEGG" id="kpin:30170155"/>
    <dbReference type="OrthoDB" id="278329at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006105">
        <property type="term" value="P:succinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20270">
        <property type="entry name" value="Complex1_LYR_SDHAF3_LYRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008381">
        <property type="entry name" value="SDHAF3/Sdh7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137">
        <property type="entry name" value="DC11 ACN9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137:SF6">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCF52496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC69271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="152" mass="17390" checksum="CEA525310E54D2EF" modified="2016-11-02" version="1">MRASLIRLASSSPPLPLSVQQASVQLIPPIPLYRRLLRAHRTLPAEMRFMGDSYIKSEFRLTRSTDNPLHIIAFLSQWKLYLDELLSSTIDGQGIWRGRKLDTDSFEKLNKEQVGQLYELMHATKEVWKSTEQLEQEAQDAGIAQPLEGGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IAF0</accession>
    <name>A0A1B9IAF0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Oligosaccharyltransferase complex subunit gamma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_01895</name>
        <name evidence="12" type="ORF">I206_103101</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the OST3/OST6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013821.1">
        <property type="nucleotide sequence ID" value="XM_019153660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IAF0"/>
    <dbReference type="STRING" id="1296096.A0A1B9IAF0"/>
    <dbReference type="GeneID" id="30170264"/>
    <dbReference type="KEGG" id="kpin:30170264"/>
    <dbReference type="OrthoDB" id="67566at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021149">
        <property type="entry name" value="OligosaccharylTrfase_OST3/OST6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12692">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12692:SF0">
        <property type="entry name" value="GH11935P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04756">
        <property type="entry name" value="OST3_OST6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628466" evidence="10">
        <location>
            <begin position="20"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCF52602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC69165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="322" mass="35722" checksum="7F761FF1E277450F" modified="2016-11-02" version="1">MRLSTLLLPLFSLLPIAFAADKQHWADIASKSKDGIIKLDSASYEEILAPDREYSVSVVLTALPAQFKCQPCHDFDPSFHQVAASWRRKAKHVRDGHFFAQLDFSDGQAVYQQLGLSSAPTVMFHPALAGPNKSNKLSVITYELNRNGLTAPPLHSFLNNLTPEGFKFYKPINPINYIAIPISILILGISIYSMRKIIIPLIQSRIIWGTFSLILILTFTSGYMWNKIKNAPYVAAGPNGQISWIASGYSNQLGLESQVVGGIYGILAFSIIALTLLIPSQSSPSKQRIGVYLWLAMLIVVFSLLIKLFRMKNGGYPFALLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IAF1</accession>
    <name>A0A1B9IAF1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">6-phosphogluconolactonase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_01689</name>
        <name evidence="3" type="ORF">I206_103305</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013619.1">
        <property type="nucleotide sequence ID" value="XM_019153458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IAF1"/>
    <dbReference type="STRING" id="1296096.A0A1B9IAF1"/>
    <dbReference type="GeneID" id="30170058"/>
    <dbReference type="KEGG" id="kpin:30170058"/>
    <dbReference type="OrthoDB" id="9972196at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF7">
        <property type="entry name" value="DUF2415 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF52400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC69366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="41811" checksum="C4BB9A4BD1A5CFBD" modified="2016-11-02" version="1">MSTYQILVSGYRDTYTILSFDPSTSKIKIVSDSKAPEKASWIEPASKQHNPLQSNRVLYSISEVDKGLAVSLNLKDDQIEITSQKETRGSPAHIHVLKDGSGLAVVNYVGGSMIFFPFNSDGTLSDNASDLLEFPFLYKDGDAPDPERQDTPHAHQVIEGEPGTLYVCDLGNDRIWVVEKKGVNTLEIKGWLQAPPGTGPRHATFSEDGKHLYVLTELTSDVLVFSLENPKYPIISKPEFKVNIIPSSVPKEASKIMNAAELILNPKKSNILYASNRLEISLEEKSKGKFKTLKDVKGDSIAIIELSSNGEELKELNFFQTDLNNLRGMTISNDGRYLLTAGRKEGGLAIYEISSNGKQFKLAGKIEKGVDNITDLTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IAL3</accession>
    <name>A0A1B9IAL3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Iron-sulfur cluster assembly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_01899</name>
        <name evidence="11" type="ORF">I206_103097</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6 7">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; iron-sulfur cluster biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NifU family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013825.1">
        <property type="nucleotide sequence ID" value="XM_019153664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IAL3"/>
    <dbReference type="STRING" id="1296096.A0A1B9IAL3"/>
    <dbReference type="GeneID" id="30170268"/>
    <dbReference type="KEGG" id="kpin:30170268"/>
    <dbReference type="OrthoDB" id="1925777at2759"/>
    <dbReference type="UniPathway" id="UPA00266"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1010.10:FF:000008">
        <property type="entry name" value="Iron-sulfur cluster assembly enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011339">
        <property type="entry name" value="ISCU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01999">
        <property type="entry name" value="iscU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY ENZYME NIFU HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82649">
        <property type="entry name" value="SufE/NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="NIF system FeS cluster assembly NifU N-terminal" evidence="9">
        <location>
            <begin position="48"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF52606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC69161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="194" mass="20682" checksum="F58472DDB26861C2" modified="2016-11-02" version="1">MMRNALLRSTATASAAVASSSIRPAIRFASRPVILNAQSNIQQGQRRMYHEKVIDHYENPRNVGNLPKGDQDVGTGLVGAPACGDVMKLQIRVGEDGVISEVKFKTFGCGSAIASSSYMTERVKGMTLEQAGAVKNTEIAKELCLPPVKLHCSLLAEDAIKSAIKDYQTKRAKRLSTANSPPPSLGSSPQVATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IAU0</accession>
    <name>A0A1B9IAU0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I206_00048</name>
        <name evidence="16" type="ORF">I206_101275</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
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                <person name="Birren B."/>
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            <authorList>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
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                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
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                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">CBS 10737</strain>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
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                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
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                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
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                <person name="Imamovic A."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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    <reference evidence="11" key="3">
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
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                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.15" evidence="8"/>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF52928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014147.1">
        <property type="nucleotide sequence ID" value="XM_019152009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IB99"/>
    <dbReference type="STRING" id="1296096.A0A1B9IB99"/>
    <dbReference type="GeneID" id="30168598"/>
    <dbReference type="KEGG" id="kpin:30168598"/>
    <dbReference type="OrthoDB" id="17102at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004105">
        <property type="term" value="F:choline-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000172">
        <property type="entry name" value="Related to choline-phosphate cytidylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045049">
        <property type="entry name" value="Pcy1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739:SF13">
        <property type="entry name" value="CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739">
        <property type="entry name" value="CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="10">
        <location>
            <begin position="285"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="200"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="219"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="448"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCF52928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC67191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="466" mass="51348" checksum="4276059186A366F1" modified="2016-11-02" version="1">MATSAAAAKRHTRNRLGERRAARDPSSSRDASEEDNDNIENEFSDVGSIVSTHADTISSTSTADSPRMQSSTSPLHVAASAIATATGSSSQPLTKRALQQKRVDELNEQGSMSEGLDSPTYDGDVESSSTIGGTPIHSSNLHHHMRSQLASSPTKSSGLGLHDITTATATSPYGTNRLPTPKASKANLQSESLILSTSYDRPTDVPVAPSKALAEPRRSQTLPLSAKPSMSSLGPPKMYTRPLELSEENIKSFVERAIHGKGAEDGIERWWRTNPPPEGKVVRVYADGVYDLFHFGHALQLRQAKLSFPKVHLLVGVCSDDLCASHKSRPAMTHAERCEAVRHCRWVDEVLPDAPWVVDQEWLDKYDIDYIAHDEEVYPSKDHSDVYAFSKKDGRFVPTRRTPAISTSDLLERIVRGYRDGFFDSKLEKNGHPELIAADVDWDSSASVEKRERRKEQAAHAHKHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9ICP9</accession>
    <name>A0A1B9ICP9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_00472</name>
        <name evidence="9" type="ORF">I206_100854</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="4">The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="4"/>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014390.1">
        <property type="nucleotide sequence ID" value="XM_019152252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9ICP9"/>
    <dbReference type="STRING" id="1296096.A0A1B9ICP9"/>
    <dbReference type="GeneID" id="30168841"/>
    <dbReference type="KEGG" id="kpin:30168841"/>
    <dbReference type="OrthoDB" id="202234at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004552">
        <property type="entry name" value="AGP_acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00530">
        <property type="entry name" value="AGP_acyltrn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434:SF11">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="7">
        <location>
            <begin position="109"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="294"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="299"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF53171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC66947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="360" mass="39427" checksum="BAC43FFFAF936384" modified="2016-11-02" version="1">MALGWLLKPIALASTLAISTLGILSRKYQRARFYYHLTLYVSTLGALSIWGVIVSILATVSGQRLNINYLVARSFYLTCSPAVGVTFEVEGEEHLTGLLTARGGKEQSAVLVGNHQSFLDILYLGRIFPKRAAIMAKKELKYTPGLGQFMSLSGAVFVNRSNRTDAVAALQAAGEDMKKKGVSLWVFPEGTRSSSAEPALLPFKKGAFHLAVQAQVPIVPVVVENYHRLFDGRTRFESGNLKIKVLPPISTAGLTSNDVTQLSEDTREKMLETLREISEVGPSGKKPTIQLDEISQPEIAKEEIKEKEKKPVHLDISNSGTEHKEEEANSRSSKSGNDSTEDEMDDDAVLLKRPKSQPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9ICZ3</accession>
    <name>A0A1B9ICZ3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_00775</name>
        <name evidence="4" type="ORF">I206_100550</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014691.1">
        <property type="nucleotide sequence ID" value="XM_019152553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9ICZ3"/>
    <dbReference type="STRING" id="1296096.A0A1B9ICZ3"/>
    <dbReference type="GeneID" id="30169144"/>
    <dbReference type="KEGG" id="kpin:30169144"/>
    <dbReference type="OrthoDB" id="6419443at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="97"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF53472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC66646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="320" mass="35388" checksum="51883A76B0FD324A" modified="2016-11-02" version="1">MSTSSLLHTALQNLHVSQQIHQQPHTPGSNYNELDSSRGGSPIPFSDGELTTTDDEGDELVQVGKGTRPSTPTTTTSSRGLQLGQRLPRSLGGKNTKDPLRTLPTHISVRIFIQLDVRALARCNRVCKRWHKSSTLNYVWFLHNRALVLPKLLLPDSPGGKTRKVNNEIEFFDPYDKKPRLSSLPQPNLPNSSQPVWTKIESKKNWRNQFKITFKRTDPTNETEIDSRRVDISSLQTSGYNTPNNGHGYKGLGSGNASKWIQDDSDGGGGLSSSEKKQQAREGYKALGGRKSKSKRKMGGELGGKDKGGANDNGRFEAPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IDE2</accession>
    <name>A0A1B9IDE2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I206_00945</name>
        <name evidence="14" type="ORF">I206_100379</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFB7 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014858.1">
        <property type="nucleotide sequence ID" value="XM_019152720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IDE2"/>
    <dbReference type="STRING" id="1296096.A0A1B9IDE2"/>
    <dbReference type="GeneID" id="30169314"/>
    <dbReference type="KEGG" id="kpin:30169314"/>
    <dbReference type="OrthoDB" id="268414at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008698">
        <property type="entry name" value="NDUB7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900">
        <property type="entry name" value="NADH:UBIQUINONE OXIDOREDUCTASE B18-LIKE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05676">
        <property type="entry name" value="NDUF_B7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCF53639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WWC66477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="83" mass="9655" checksum="91F4611757D5D55C" modified="2016-11-02" version="1">MTSSTTASQSELEAARVPLGWRDQCSALLIPLNVCRHKTLYMPWKCEDERHGYEKCQYDDYMRRMKQLTRQKKAAAEAAAEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IDG9</accession>
    <name>A0A1B9IDG9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_00764</name>
        <name evidence="5" type="ORF">I206_100561</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the p23/wos2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014680.1">
        <property type="nucleotide sequence ID" value="XM_019152542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IDG9"/>
    <dbReference type="STRING" id="1296096.A0A1B9IDG9"/>
    <dbReference type="GeneID" id="30169133"/>
    <dbReference type="KEGG" id="kpin:30169133"/>
    <dbReference type="OrthoDB" id="1564555at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06465">
        <property type="entry name" value="p23_hB-ind1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000101">
        <property type="entry name" value="Wos2 protein (P21), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045250">
        <property type="entry name" value="p23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932:SF1">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DAF-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN P23 HSP90 CO-CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="3"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="185"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF53461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC66657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="242" mass="26084" checksum="92F36A9BD01E172D" modified="2016-11-02" version="1">MAPIHPEVTYAERCNATEPEKNIIYFTINTPDIKGEPKLEIKPTEISFAAKAGDASKGVPEKEYAFDLQLYDEIIPEETKKVITSRAVLLILRKKEPRSEYWLRLTKEKPNRNWVKTDFSKWVDEDEQEGAEDPTAGMDMAGMGGMGGGMPGMEGMGGMGGMGGSMPGMGGMGGMDFSKMMEQMGGMGGMGGGMPDFGAGEDDEGDSDEDRVPEEEEDIEEISTSGAADKGKAKVSGLDDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IDH1</accession>
    <name>A0A1B9IDH1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Kynureninase</fullName>
            <ecNumber evidence="4 5">3.7.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Biosynthesis of nicotinic acid protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">L-kynurenine hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BNA5</name>
        <name evidence="7" type="ORF">I206_00832</name>
        <name evidence="8" type="ORF">I206_100496</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>L-kynurenine + H2O = anthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16813"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the kynureninase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.3" evidence="4 5"/>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014746.1">
        <property type="nucleotide sequence ID" value="XM_019152608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IDH1"/>
    <dbReference type="STRING" id="1296096.A0A1B9IDH1"/>
    <dbReference type="GeneID" id="30169201"/>
    <dbReference type="KEGG" id="kpin:30169201"/>
    <dbReference type="OrthoDB" id="5978656at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00329"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00334">
        <property type="reaction ID" value="UER00455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
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        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084:SF0">
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    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4 5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="3 4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="6">
        <location>
            <begin position="183"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
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        </ligand>
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        <location>
            <begin position="145"/>
            <end position="148"/>
        </location>
        <ligand>
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        <location>
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        <location>
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            <position position="289"/>
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        <ligand>
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            <position position="261"/>
        </location>
    </feature>
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        <source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
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    <sequence length="471" mass="53181" checksum="99F3662DB2C2AF54" modified="2016-11-02" version="1">MANSTDKIPTIDDLIKLDQDDPLNWTRDEFEIPNIKACGGEGDGGAIYFCGNSLGLLSKKARKHMIEELDVWSTSSVTGHFSHPHKRPWKHVDQPLTPHLAKLVGAKESEVAHSSTLTSNMHNLFTSFYRPTIKRWKIVIEKGSFPSDWYAVHSHPKLHEAVLSPQQIDEAIIGLEPREGEDTLRTEDILKVIEENQDEIAIVWLPLVQYYTGQLFDIATISPKVHSIGALLGLDMAHGIGNVECKLNEWDVDFAVWCTYKYLNSGPAGIGGFYVKDGLDNGGRRLAGWWGNDSATRFQMLPEFNPTKGAKGYQHSCTPVFSSIPLLSTLELINKIGFNKMLKKQKDLTGLLEKLLKSSKYYKPFLNTKNQNELGFKILTPEFPFRGTQLSISILPENNKEIMPKIFSRLIKNGLIGDERYPNVIRLSPVVLYNKFEEIGKAFKILEDAFKAEEDGKEFENEIDLDMISKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IDS1</accession>
    <name>A0A1B9IDS1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_01165</name>
        <name evidence="4" type="ORF">I206_100163</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="protein sequence ID" value="WWC66262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44360">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="75"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC66262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="377" mass="42826" checksum="BC8C0897F7B0ED0D" modified="2016-11-02" version="1">MSSLLTPLLWSFLPAQITHQILPYLSSFLPNVFPTSPRGSPTYLRNYRIAFTGVICTYLAYTLYKGENSQSSTEDYYALLGVSKQVDEDGLKRAYRNLSRLYHPDRAGSGDDSIFILIRRAYETLNDPIKRYAYDRFGPQIIDWKAASIREYIITGLNHSVGFYIISGAIMLALSLLGKAREGSYWRHTLFCLLLLSELHLILSSTSSLPLFSSIPKVIDKIFPILSAPQFIQIAFLHRIFTTISIAINQLTNVWYPSPTKTTDEDWIKVVSMLRQLEMESITSFQSEILPLLSSGNPKNVEILIKNNMEDILVERSISSHPQIRQVYQKAILKPIPRILRTQRSTKIDLDNFEIAKNIPLPLSPPSSPTLSPIRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IE51</accession>
    <name>A0A1B9IE51_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_01007</name>
        <name evidence="4" type="ORF">I206_100318</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
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                <person name="Sykes S."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
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                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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            <authorList>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
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                <person name="Chapman S.B."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
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                <person name="Zeng Q."/>
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                <person name="David-Palma M."/>
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                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR038169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC67215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="355" mass="39626" checksum="85E3491964B21ED4" modified="2024-07-24" version="1">MPDIKLRNQPFDLVFHPKESVIFSSLLTGEVKAWRYDDDNGSTSSSWSVRPSKRTARAIAVEESGKNVWMGGKSGTLFQMTSEMGTIVREQDKAHDVPINRVHCINENLIASGDDDGIIKFWDPRKPEMIREYNQHFDYISDFTYFDDKRQLVSTSGDGHLSVIDIRSNKNQPLTVSADQEDELLSIVQVKGGQKAIVGSGLGILSIWNRNLGWGDSVDRIPGHPASIDAIVSLTPDIIATGSEDGMIRVLQVLPHKFLGVIASHEEYPIERIKLDRNSKWLGSVSHDECLKLTDVSDLFEDSDDEDQEIDSDSDSDEEVEMEIEKKKKKKGKGGLGDLGRGGQEQETTDFFADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L2L6</accession>
    <name>A0AAJ8L2L6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA replication complex GINS protein PSF3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_101901</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GINS3/PSF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058574.1">
        <property type="nucleotide sequence ID" value="XM_070202473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L2L6"/>
    <dbReference type="GeneID" id="30175377"/>
    <dbReference type="KEGG" id="kpin:30175377"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11713">
        <property type="entry name" value="GINS_A_psf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21693">
        <property type="entry name" value="GINS_B_Psf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010492">
        <property type="entry name" value="GINS_Psf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038437">
        <property type="entry name" value="GINS_Psf3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055221">
        <property type="entry name" value="PSF3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22466">
        <property type="entry name" value="PSF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication complex GINS protein PSF3 N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC67982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="190" mass="21119" checksum="332743C413A63F85" modified="2024-07-24" version="1">MDDDYFSLNSILADNHKLSCSFTLDVEGLGYLEGGTDNNIHQHSKVELPFWLAQTLSLNEFTTFPLPPPYSNRVKSALNASAQSVKLSNLVGNNGWWYRWGRRIADVLDDEPQADLLNMLLKAFTNRLPALQDLSAHHASADHTLPEGSTSTGELFRDGMEGDERELFAIGQESGKMAKGWYDSANSRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L3B2</accession>
    <name>A0AAJ8L3B2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sm protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I206_102088</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the snRNP SmB/SmN family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC68165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008264.2">
        <property type="nucleotide sequence ID" value="XM_019158518.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L3B2"/>
    <dbReference type="GeneID" id="30175188"/>
    <dbReference type="KEGG" id="kpin:30175188"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070990">
        <property type="term" value="F:snRNP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01717">
        <property type="entry name" value="Sm_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000047">
        <property type="entry name" value="Small nuclear ribonucleoprotein SmB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="130"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC68165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="196" mass="20008" checksum="28FB3CD01426EDCA" modified="2024-07-24" version="1">MVTLVHYRLKVTLNDGRSLVGQMLAYDKHMNFVLAECEEFRTVKGKKAKGATKGEPAPSVQQKRTLGLVILRGETIVSVSVEGPPPVQKDEGALLAGPGKGLPAGRGMPLGAGAPGAMAARPMAYARPPPGFPPGMPGLPPGMPPGFPGGAPGLPPGMPPPAGMPPGFRPPGFPGAPPSGLPFPPGQMPPGFRPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L421</accession>
    <name>A0AAJ8L421_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_102666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012176.2">
        <property type="nucleotide sequence ID" value="XM_019154773.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L421"/>
    <dbReference type="GeneID" id="30171388"/>
    <dbReference type="KEGG" id="kpin:30171388"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC68732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="372" mass="41335" checksum="85DDCB7AC943BBF5" modified="2024-07-24" version="1">MRFTSPHAKPTLTPVGYRLLQLSEKKLSNMDGSLYDEGPALLKGILVKEAIRSAWQSVQEGSVVEMNDWTSMSAMGLEVVSEEDEEDQVEAEISGNPSASTAREERWFEDLVSSFGEDDLENSIPQPEQHEWVESNVSEPVFDDYDYDYDPTQMEAFTFPSPTSPLSPVAIVPQVRVTDVEIVEVNDGECEAEAGFDRSKSTIERLDSTSLVHVENRQHDHLTPVLKPLSSGGLVPPSPIEAITSVSVSPEWDESIYPYPQPYYTEMDDYIDDFYLPPPLIRSLSSGSTHSMEGEECGTPPLRYSELNDQPSWIDQLKNIDDLIENSESSDDEDDIGARRFTESDEEGDGSKLVGGVIGMALGFVDEGFVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L516</accession>
    <name>A0AAJ8L516_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex subunit Exo70 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_103633</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EXO70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058905.1">
        <property type="nucleotide sequence ID" value="XM_070202804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L516"/>
    <dbReference type="GeneID" id="30169734"/>
    <dbReference type="KEGG" id="kpin:30169734"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.170">
        <property type="entry name" value="Exocyst complex component Exo70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046364">
        <property type="entry name" value="Exo70_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03081">
        <property type="entry name" value="Exo70_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex subunit Exo70 C-terminal" evidence="4">
        <location>
            <begin position="350"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC69690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="724" mass="80291" checksum="37AC4E1845F7309A" modified="2024-07-24" version="1">MDEEADLALLDQHLLKTNLLSQRMTNILGQLDNRLSRLDKTIAPLGLQPLTRKDANIESILLQLEGKSNTSIITKSPISSSLAPIRPIRNIPINSSSTSMINTTSTNGNGNGNENENGEIKSISKNSSINVKGYNLGNPIITNLKTSDFNLNEEKNEINLSPIQSNNPSINNSPADETAILIRGPDLMSLNEFFISIDGVILDLERMFKGLMQGRGGAREIGVKDLSNLVEIGFSGLTQLFLKVSKDGMGKTIDAESVLNNGPPTPPNYFSPLNTLLPLVNKITTILYPQNPTPKTSSIVQPIWDQTIATFGDMRGDWLCRCLSRLISRLEESDEGGIWSEGRGREKVQGLTVCWESLLSLVEAETLLITTLFPSNPPTNLLQFTLHAPTESLTRLLQPTLNTVKRSLSTHIYLALDLYRSLTTIQSTWDTIISKCLSMTNTPTSHETKELLSILNQPVSTLRSLSLRSFPELLVDIKSSRIDGPLTSSIADITYSTLGYLENMNGFEKLIEGLLSKSHSERSWLMGQKESPSPARNASEEGGIVNLFVADVLGTLLQHLDARARNMRRPIGQAFSLNNLSHIRNTTSSFKSDIIGPGAEDMLNKAFRDAKGQYLSEFHSLVNTLTTTHSTPRFGVTVPQGERHNLKESATQFFDKLAELENVILQYPLNRQDPDMRDRISREVEVIIRNGYEAFWGRCAGKGIEKYLRGSPDDITRRVQAMFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L5U2</accession>
    <name>A0AAJ8L5U2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_103907</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC69963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058953.1">
        <property type="nucleotide sequence ID" value="XM_070202852.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30172889"/>
    <dbReference type="KEGG" id="kpin:30172889"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF561">
        <property type="entry name" value="PROTEIN TYROSINE PHOSPHATASE 36E, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="6">
        <location>
            <begin position="361"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="718"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="895"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="310"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="995"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1182"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1284"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="995"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1025"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1048"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1062"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1182"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1198"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1209"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1287"/>
            <end position="1337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC69963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1364" mass="145909" checksum="8DDBB1E3E89F1BD9" modified="2024-07-24" version="1">MLVEQTQKGLEQGDRSASISRTNVNDNQGEDVEWSNASSSPKNSNFSPPSSSFEFSFPAVNQTPNRRRQAPPTSIPNFPSSHEPRNPPPTVPFSPSPTYSPMVSSPFRSPDPPATGPASRIPSGFSIPLSQPFATPSGGSGVTSPWHSLAATSGAPTPSLESGPMGRASPHLGYPFERLNIGGSWSGANLWGEGSLDRRGSADSTGAGGGLGSSPGKGSLQLSSPPPINLPPPGPSRGLSAETLLRYKAMATPGSGPMPTAMAKGASQGNPMDNRASSSRASSNEPATLSPNLPQGLARRRGSLPKAALGVSSLSLPPSRAGKSPSPLASTSTNSSPGAGAGTSGKRLQPISAKSLVPLLSSPSTLVLDVRPPSLFHDSHIPWSHSLPIPSTLLRRPAFNIEKLAGMLQPKSTEAILRWREKGDIVLVDSDSGSVADGSVLDGLSSKFEREGYTGHLWFVKGGHSALTHGEVRLVAEDEDVEIENLQAESKAGLSKGLMAGQLSTLAFKQESTGPSKGRKAPPTGLAMPATPGFSLKNNPFAISMPAAQTSTTTERPGNLSARDLTLSDMPSPKKAKFQPANPFFDNIRQNLELSHGGITERIPLNLPDQVMNRVEDLPVFLKDLATMPEKQSMDQLAKQFYDLELNEQKRLQGVMEWHSKGSGGLLGDRAGRESWADKRHHDAEEVQRLTNWNGEEATFQEDYFPFSITAGVERGTKNRYKNIWPYDFSRVRLERPPDCDSDYINASYVQPRGTSRRYIATQGPLDATYHDFWTLVWEQGVTVIVMITKQFEGGLIKCGNYWESSTYGNLKLQMISQSGGEDHAYQAPTTGFDFGSAAVTPQSSSFPTGKEKNIKRVFRLSNLEQPTEPPRTIIQVQCIGWPDFDVPETPDTLLNLIKDVDLAVEESDSTGRADRSDRPPVLVHCSAGVGRTGSFIVIDAILDALRRDLRRRRESTDSSSGFEQADTEKPFSFPALQVPVAVGHSDSGKAVSFLTPQASGDVSNTDLQRSVLTSSPNPIDATEDSNASLTEDALAQNNAGRTGSGEVGEEMDIDESPADPPPDRFFEHRGSVSTDFSSEAGGGTRRPSLASTKHSSDLLPLEARHARNAAANDKDSNVPMPIIRSDTKHRSPSPITEMPNPVASVLEGMRVQRMSLVQSLRQYLFVHRAIIHSYLHILDEENGHHGTTNDRSRSRSKSLSAGLSGSSFNTTKSNSTVGSTGTYGTEDESHIKRRASPTELEIEKPNPEISSSSSPLIRHLEESSLGSGSSLTKRPSFKKMRPAMDSLASGSSASGTSSISNGNSSVTSNSDILSNASPSSNPSALLTSPKKGGSLRSKSKLGMDDGASKTFNFPSGSKGDEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L6A3</accession>
    <name>A0AAJ8L6A3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Adenine DNA glycosylase</fullName>
            <ecNumber evidence="3 13">3.2.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I206_104315</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Adenine glycosylase active on G-A mispairs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.</text>
            <dbReference type="EC" id="3.2.2.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the Nth/MutY family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.31" evidence="3 13"/>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059034.1">
        <property type="nucleotide sequence ID" value="XM_070202933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L6A3"/>
    <dbReference type="GeneID" id="30172477"/>
    <dbReference type="KEGG" id="kpin:30172477"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034039">
        <property type="term" value="F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035485">
        <property type="term" value="F:adenine/guanine mispair binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032357">
        <property type="term" value="F:oxidized purine DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000701">
        <property type="term" value="F:purine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03431">
        <property type="entry name" value="NUDIX_DNA_Glycosylase_C-MutY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000002">
        <property type="entry name" value="Adenine DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044298">
        <property type="entry name" value="MIG/MutY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029119">
        <property type="entry name" value="MutY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944">
        <property type="entry name" value="ADENINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944:SF1">
        <property type="entry name" value="ADENINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14815">
        <property type="entry name" value="NUDIX_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="15">
        <location>
            <begin position="137"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="WWC70365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="563" mass="62428" checksum="A92E779BD9EDEA24" modified="2024-07-24" version="1">MRAGPSRSPSVISIPESDGSDYQPVQEKESPPLPTRTSIKRKRPSVVKRTLTKKSTKIKNEDEIEDIEDTAGPSILRDHGLEYHSIGGIAGKQEDLLSWFEGCREKRGMPWRKRYDPNLSMKEKGQRAYEIWVSEVMLQQTQVATVIAYWKRWIEKWPTIADLAKADVEEVNAMWRGLGYYRRARSLLAGAKTVMSDPKYEGRLPNDPLVLEKQVDGVGRYTAGAICSMAYGVRTPIVDGNIHRLFTRLLAVHAPQTAPSTIKFLWQAAEELVAKLPIDGHRTGIAGDWNQALMELGSQVCKPVSPDCGACPLRSCCKAYSEISSFPPQPLELVCTICAPIPLTAGTNGISSVSIFPMRKEKKASRAEEESVLVTEWKGDNGDRKWLFVKRPEKGLLAGLFEPPTTPVASSSTPDICLDTSLASLLELIDSPMSDSQKTGQSRYVTSIPHIFSHINMTYHVHHLVLSTSSAQPPTIYESDKTVVWLSEEQVIHANIGTGVKKVWSEIYGSWASFEVDSTKIKKSSITAKKGGQKKLPLAEVKNGKIVKKVMMPSMPSKKVEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L6R9</accession>
    <name>A0AAJ8L6R9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_104089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058992.1">
        <property type="nucleotide sequence ID" value="XM_070202891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L6R9"/>
    <dbReference type="GeneID" id="96955741"/>
    <dbReference type="KEGG" id="kpin:96955741"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC70142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="214" mass="23023" checksum="41BD369C6745BA04" modified="2024-07-24" version="1">MFQKVSDKFHRKQQSSASNKSNPSSPSATSRNTPTSSAPSTPAAVAPSSPLVEVKSTHTPMEGIEGGPIPENQTPVSESRTMSIQMTDVSEQEPELKRNDSAADEERIREKAREAQEQAAQAQANLQMATQQARVAAINAAATQAALETVSTATPQVAPAPAAAQPQRKTAGRYALSDFYIERTEIQAQWSILRGQGIEQRESHQDEASGAHQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L916</accession>
    <name>A0AAJ8L916_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dihydroxy-acid dehydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_105749</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IlvD/Edd family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC71790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059285.1">
        <property type="nucleotide sequence ID" value="XM_070203184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L916"/>
    <dbReference type="GeneID" id="30172938"/>
    <dbReference type="KEGG" id="kpin:30172938"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052352">
        <property type="entry name" value="Sugar_Degrad_Dehydratases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43183:SF1">
        <property type="entry name" value="HYPOTHETICAL DIHYDROXY-ACID DEHYDRATASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43183">
        <property type="entry name" value="HYPOTHETICAL DIHYDROXYACID DEHYDRATASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="7">
        <location>
            <begin position="227"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="8">
        <location>
            <begin position="365"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC71790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="589" mass="63199" checksum="6BEF7E586C7B7CA0" modified="2024-07-24" version="1">MSQPCEGCNCGRAEQAQVPTAGIGPRQLRSFTSPADSNPNSTEGIEPAIPLRSKKWFNDPSDLGLTVPELQPKNRPIIGIAQTGSDLSPCNKYHVELAKRVRDGIIAAGATPLEFPCHPIQETGKRPTASLDRNLSYLSLVEVLFGYPLDGVVLLTGCDKTTPALLMAAATVNIPAIAMNVGPMLNGYSGQKLIGSGGVVWESRAQLAAGEITEAEFLHHVALSAPRERGACAYATGLRIVQLVREDVKPSDIMTKAAFENAIACCATIGGSTNAPIHLNAIAKHVGVELNCDDWERVGYHLPLILNVQPAGQWLCEEYHRAGGLPAVIAELLEHEALPNPDALTVSGKSIGDNCRGELSQDRRVITPFDKPLMAEAGFLHLKGSLFDSGIMKTSVISPAFREQYLSNPDDPMAFEGPVAVFDGPEDYHHRIDQSPNISPGTILIMRGAGPVGYPGAAEVVNMIPPGELIKKGIELPCIGDGRQSGTSGSPSILNASPEAATGGMLGYLKDGDRVRIDLLKRTADVLLSPTEIEERKKSMGDYQYPKSQTPWQEIYRGSVSELSEGMVIKSAVKYQRLAQTQGIPRQNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LAC8</accession>
    <name>A0AAJ8LAC8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alpha-mannosidase</fullName>
            <ecNumber evidence="3">3.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_106395</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Degrades free oligosaccharides in the vacuole.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.24" evidence="3"/>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059411.1">
        <property type="nucleotide sequence ID" value="XM_070203310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LAC8"/>
    <dbReference type="GeneID" id="30175568"/>
    <dbReference type="KEGG" id="kpin:30175568"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009313">
        <property type="term" value="P:oligosaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.50:FF:000004">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.110.10:FF:000002">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.30:FF:000001">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="entry name" value="Glycoside hydrolase 38, N terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="entry name" value="Glycoside hydrolase family 38, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054723">
        <property type="entry name" value="Ams1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017:SF1">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22907">
        <property type="entry name" value="Ams1-like_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="Families 57/38 glycoside transferase middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 38 central" evidence="10">
        <location>
            <begin position="559"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1148"/>
            <end position="1168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC72433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1168" mass="132683" checksum="673EAAB30123EE7A" modified="2024-07-24" version="1">MSSYETVNHKKVDYPQRTDQARYKKLGSTHGRLDQFIGGHYADYNLSSLLFAHRLDDPNHVKIEVWSAPNRSKPSFEEAKRQNYRLAHKGEEFGPSWSNHWFRITLHIPPEYSEYERIQFEFDNSGEALIYTVEGDPIHGLTGGFNGDRRVEFIIPQSDRDAGVSHFYIEGSCNGMFGIDDMDPPNPNRYYRLNSADLVVPNMEAWRLLWDFNAIHQVYNTLPDDSPLSKHSMYVANEIMNTFKRGSLESVTKARKLAQEILGKEWEKEIAKDSKNAVEQKGTLWGVGHCHIDTAWLWPFSVTQQKSARSWSTQCDLIDRYPEHRFSATQAQQFKWTEELYPTLFARIKSKVAEGSFQPLGATWVEMDTNMPSGEALVRQFLYGQRYYQSRFGIKAKTFVLPDTFGYSSQLPQISRQAGAPNFFTQKLSWNSINNFPHTTFNWVGLDGSQVLTHMTPVDNYNSQCDIGEIRRGMTGHKNLDVTEQSLLLFGNGDGGGGPTPPMLEKLRRARAIGKRSDAGGQLPLVKMGGSFDEFYDSVRKETDNATKLPYWRGELYFELHRGTYTSHASIKKGNRKSEILMREAEYAATIASLIDPDYEYPKKRIDSAWEDLLLCQFHDVLPGSGIAMIYEDAEKRYASIQSSIHAVLNEAYSVIYHSSVPISAEEPAKTSGPIFAVNTIPDYARQEVIEIPLEAHVQIQSRAAQISKDGTIGYLLLSTKNSTPSPNQNCGRLTPNEHQGFMLCNPRGLYANPKVEVKEEYKGLFIMANDKISMRIENGRITSIYDKALDKELIPAGQTGGLVIMEDHPNYWEDVDEFHLEKQTHLDFESVHIKEYGPLRAIIGASLQIGQSRIEVNISMDAIAASLKDDARSMIRFDATIDWREKHQFLKFELPLDIYSDFATYDTQFGTVARPTHRNTTWDAAKFEVCGHKFADLSEYGYGVAILNDCKYGYATQGNIMRLSLLRAPTQPDADCDMGTHRFSFAIYPHKGTFVESDVAKVAYAFNAPMNLRYSKEPIDIALEPLALSCPFRLENAPNVMLETIKRGEDDDFSGEAKTIILRLYEHLGGHARAALKVHGLDVIKAEVTNILEEHVEHLKIHKSSDFIQDSDDVEEDEKKPKKDESVSVKLSFRGYEIKTVKLTLGNDHKKKGDKKRRESECSWVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LBX2</accession>
    <name>A0AAJ8LBX2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">High-affinity methionine permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_106387</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059409.1">
        <property type="nucleotide sequence ID" value="XM_070203308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LBX2"/>
    <dbReference type="GeneID" id="30175560"/>
    <dbReference type="KEGG" id="kpin:30175560"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF353">
        <property type="entry name" value="METHIONINE TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="437"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="484"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="513"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC72425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="601" mass="65224" checksum="C474690B476A6DD6" modified="2024-07-24" version="1">MGHESCSWMTPALCNVAHSPDSDYKHSLPQTPASITGAAGADYIEHLNNGSLEYVAEYGGNGATATYQEASGAPVEQTSPLGYEVSYFTVMFLTINMMIGTGIFSTPSSMLRNCGSVGLALFYWPIGLLITACGQSVIFELASYFPSRSGGEAVYLEQAYTRPKYFLPVTFAVQSAVLSFSSSNAIVMAQYIYRITDATPTDMQLKGTALACWTLACLIIILSTKGSLILGNVLGVIKLATLVFMTIVGFIVLSGKTKISEPTANFHNSFEGTHNTGAYELANALVNITFSYGGFNNAFNLVNEVKNPIKTIKRTAPLALVIVATLYTLVNIAYFAAIPKAEIKASKQIIASLFFQKVFGAKAAKGLTILPVLSAFGNILSSLIGSSRMVREVGRQGVLPYPKFWVSTRPFGTPIGPVVFKWVMTSIMILGPPSGDAFNFIVALQNYPESVFIFLMTLGVFFIRKQRKLLGLGRSEFKAWDAAVILYLASKVFLLIMPWVPPRAGIYGGAFSFFYATATLTGLAILAVCGIYYVIWIYVLPKLGGYQIRQTVLEFDRGAVSHKLVKVKNEDVVEWDSTHDPAGRALLATPSTVPILDEKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LCK8</accession>
    <name>A0AAJ8LCK8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_107055</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC73090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059547.1">
        <property type="nucleotide sequence ID" value="XM_070203446.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30173771"/>
    <dbReference type="KEGG" id="kpin:30173771"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13246">
        <property type="entry name" value="PH_Scd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033511">
        <property type="entry name" value="Cdc24/Scd1_PH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051266">
        <property type="entry name" value="CLCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579">
        <property type="entry name" value="CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579:SF43">
        <property type="entry name" value="ZINC FINGER (C3HC4-TYPE RING FINGER) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15411">
        <property type="entry name" value="PH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="944"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="259"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="340"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="395"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="455"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="647"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="803"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1019"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1119"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1655"/>
            <end position="1677"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1839"/>
            <end position="1866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="342"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="400"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="475"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="492"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="679"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="720"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="754"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="814"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="844"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="890"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1022"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1066"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1134"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1150"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1657"/>
            <end position="1669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC73090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1906" mass="208838" checksum="A4C8C8DFAA915E96" modified="2024-07-24" version="1">MPTNFLAPHPHTVNDLPRSPSPSPLLKQGFTAEDLSVDSPDLEDYPFVTDGLQVSFDIKCEEKTEDGLNENDEDEQDQDELIIVDPCLTSYSTQTQIHAQTDKTDFIPPTITDTIILPSASQHKPGLPLISRENATRSSASFINLASPLLGSPQRLDQAALLDKIQSELRDLRLTRSLSSPLPLNQSFYTYQKDNYALDSTLDPLSYITDKKRRNMSTKIPEGQSSFDFGDQLLATSPWKGLRRALSLGSSTSANFGSKRSSTITKLSSRQSRTRFTSNHKHGHTSAGASDNWDYKDHKKALSISETDLSDIIDILERDVEDQMDIEDEWHNNMVVWKEGESSSISGNSASASRSIESRHMSRDQVPSGPSSPCDTDRFSLSDYTSGLLFPKPPSIIHTNNNNNNNNNNNNITTQSDRSLIDPSFPFQSINQTQTQKHTNSSSISVVDNGRITPVSFESIGSQPSYCPPSPASTPSPNLSSSNSPILITPSVQPSPTNSTSDLQAVHGNEVDKKGSEVGTKSIIENTQAVPLVPKLSGLPPLVPRTVIPSGSTAPLSFPSRNKNTSTSAETTVPIDADNNVDQSDCPTIRTINDNVNNNKHIESLQPPIVLLASDKDNTTHAPSPFRDPMSFGERSIEGRERDWEYHNRDTLDPHPPQAADIIKHIPPPLSYHPHHKPQQPSVPFSTRTTSTISGGNNSRFSGVDPLDTLSPPPSYGQFSNSSSSSRRNSKYTAFSGSSGSSTHSYSTTDSFSWRGNHNPHNQQHWQFGGQPDISTVFEEENSADLGEDKDFPKKDQYEFGVKHSAEPNHQKYRTLNTQSSSSTLVNRPANRSTPGYFSRERSGTINSQTGTINSNHSGKSSTSKGPTHPFANAVIRPTSPPSIPTSKSHNNFLSPQATRPENQILIQTSRSSPNLAEQYKMSQPAHQVALVSTEDDRDDEEICPVCVESLSFTYRLPGEKPHIVPECGHALHEECFVIVYGDVPPEGSKKILGVCGVCRQPMKMADGAIKRDKLATLMGQPGQNGARKSSQSAPSARSVGGRGHNTSPALADPYADDPVEIGNMSSSRSMHSESSQPKVVVPSISIRSEYPSIAKGQRTGKQVITAMVTVEVPSAGDRGKYATTLRPPEMSRSALSEDQFSPQLPPSPRSASDSSVIPNTARSGPVTSPDPFAHVVNDLKHRVVDYRTSGLDQLGSLRLFDLLSVRKGQLIREFHVYLFQEALICVSEEKKSGFRGIFSSSSSIRSDHSGGSHHTRGVLKLKGRIYVRHVKKVTDTSVQGELSLTISMEDESLDSFILCFRDRSSHETWRSTINRLLEEVKGVQSKSLRLPRSANTPLSAGGSARNFGLDLTSPSTTGYAATPSTSSFAHNDASPGDLAHEQPLGPIHTPVDLVIVLSLPAPSQSNNQLPLKVKLMKSSLAFILALLGPKDRISLVTCEMGANGIARRTPFLSPCKFESRKRLEAFVETLGSSREGKDEFEVQVGREERYDVVTAVNVALDVVLQRKAKNPISGMILVSDTSDVIKRAQMDLVTARLDAANIPVHALGYGRSHDPSPLWIISNHTHGTYTFVKEWYHLRDTLAGVIGGLMSIAVDNMRVHLSCQENDFHVTKVSGTTQAIVSKNGKDVDIELRELRFGEIREILVELDLEGKSSNEQRYSGEGSSENGHLQDAQHGSLIRKEPSFNVDRGLGLDTLSVGDANALRDVVYEDALIDEVPVIEVDCSFHDPKAGRSVARLAHPVLLTVAILPPNAPPSSTPADPMLVRRRMELLASDMITRALLIASRKNFTHASRILRETKRIMETIVDGLRSHVNGNSSRSKRDAQTIFAIDGLLGAIQDLDGLLDGLEEHKELFERDHRNYSAQQAGVLRAQRSWTKRTPTERTYCTKEIGEIINMSGEWQGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MMP3</accession>
    <name>A0AAJ8MMP3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_101719</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008633.2">
        <property type="nucleotide sequence ID" value="XM_019158020.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MMP3"/>
    <dbReference type="GeneID" id="30174683"/>
    <dbReference type="KEGG" id="kpin:30174683"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="275"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="78"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC67806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="680" mass="75403" checksum="4681B7F6EDB2CF87" modified="2024-07-24" version="1">MSDLDWIVEAGLSSDRERLVVKRRRTVKARCQRLNPETDSCSRCDRLSAECRTTQPKRVFPTGTSIAHTANANVLSLQARKRRRSEERYNESNERENSSLSSNSLRTGKLANQSDHPSFASKPITNASISLSAHLATEPRILGFTSLSSLRDEIAVSYGRRGINEWGLSLSVTEQPLSDYATYVSPLNPILLSHEVFSPARMSVVTISAVCAVAALSRKTPTSVFLAAKDRLVDLLDQSDVLKVASVANIQTLLIATSKAELLMNHRQSSGGSLSFQRCSSAIRMAQELGLYRNDIDFPADIAMSRRSAWRSCLIADRWLAAGYGLPQIIDLDDCDDVSGVAETDPQMILQAELYNASILLGRVLKEIYSPKVLARTNDDRIEGLIMAIDSCRSRVNDVLRFSPASEVGRVVFELSILTVEALFLRGVSSTKIRRPSHLTYRSSPGRWKAIWDRSQKLVSWIGEKGDWLLDTSRIGLYGLTFCCLMMFRDHSQTHSSTALYGLQMASHATFRWAQGSGDLTYMTDGRQNHAQIIRTLYIVARDGVIGAKPDAALGERLHVVSPLAEGKHRHAYTKADSEIERRSQSTTAAADLNDPLAAELEVGQSLLKLTDANTLSQPTPVEPMFGMPTDLTNLDTFNMLGFDGVKDSRHEEMAWSLPPMDKWLDEILEAEANGTNWTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MNP9</accession>
    <name>A0AAJ8MNP9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_102807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="WWC68871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058726.1">
        <property type="nucleotide sequence ID" value="XM_070202625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MNP9"/>
    <dbReference type="GeneID" id="30171530"/>
    <dbReference type="KEGG" id="kpin:30171530"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="628"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="723"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="969"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="222"/>
        </location>
    </feature>
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            <end position="247"/>
        </location>
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        </location>
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        </location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="969"/>
            <end position="986"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC68871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1030" mass="110991" checksum="3DDD96DD6586F619" modified="2024-07-24" version="1">MPRAKPQPSGLGIEDELSFGSDEDLLAEVGEINLAQQGLSSPHQSNVNQSDTNGKAERTKSSGKFKLGVGKDKDKRKRTATDETIKLSHQSTSSKRDNGKSLAKSSLVIDPLLVESVLDVSASANTVNSPRASGLKNGSRNSLSMSSSTKSPSLSITSSSKHDLVSLSAVGGGKKKGFMSSLRSLGGNKDKKEDMQYRYGNGIGHNKPHRPDLASIRSRDSFGTRSDISRQQSFDLGSNNTYSSSDHSMQKHTLAPISMSPFQGHPPDWTPDSATRSSISASSSSKRPSISSFARRASVITSTSFATSENYNPGEESPILSKAVLHKFPIVDEPQIPDSDVNEDRVSPIRQETESRKNITSLAIPPSPQISSHIFSVLLPSFPATISALSSIQILQATVIRKILPISGMPDKEKSTSLKSLTSVLSSSNGGSGNQSTRKPIWITQQLVLTSFKIGGSTPTSTPEPDEYLSKPSTSRTIAHLHLFSIPGGVNSNARSPSKNGPIGLGIGSSQSGFSRRPSLPSNAMSEENELERRIISHDCTAGVCNEDENGRKFVMRIGFGESQQDENENEWIVEMRNADQTQEWIRQIKSIAVVVRAEREGHGHAIRNAYSDAIRGDDLSLELDLQRNSSPSIKSPTSRSNSVVPSQRNSAISEMPIPEACSMERSSSAARAESPDMLPPTPIVEEISGQLCSMNLGPEVLPTARIRSKSFNKGQFDIQANAVSPSSSNASGGLGGISRIGGSLHRHAKKDSWSSSTSGGSSILPRRYGGLQPPPPPMAPPPNVPLPALPNGSSASPSASRTAMHNQMSNQSPSPEGQALSQDNANRTKHQNSSPLSSSSGKERSFNTFKPIPLVPEMESNPKMNNNNLNNSPIIVDSPSKAIIRSPTPPRKSTKPVENTEVEGFYTPETIETPTLSLSNNKFTSTGIEGGESNNTLDSILSTPNTMNNEFNKQIDNENEDNKHYASSINSFTPSFESKSTTNSSARRRREKKIAIDIMSEFNENPDAAFLVDGEEEIKEDRPRVIRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MP56</accession>
    <name>A0AAJ8MP56_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Guanine nucleotide-binding protein subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_102487</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">G proteins are composed of 3 units, alpha, beta and gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G protein gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058667.1">
        <property type="nucleotide sequence ID" value="XM_070202566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MP56"/>
    <dbReference type="GeneID" id="30171207"/>
    <dbReference type="KEGG" id="kpin:30171207"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031681">
        <property type="term" value="F:G-protein beta-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="G-protein complex gamma subunit Ste18/GpgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.260.10">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015898">
        <property type="entry name" value="G-protein_gamma-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036284">
        <property type="entry name" value="GGL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041848">
        <property type="entry name" value="Ste18_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28189">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28189:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G-gamma"/>
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    </dbReference>
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        <property type="entry name" value="G_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="G protein gamma" evidence="11">
        <location>
            <begin position="11"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC68558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="103" mass="11546" checksum="EBB9F1FD0F0288E4" modified="2024-07-24" version="1">MSSRTNKATMHELKLRRLMEHNHRLREELARPRVMVSVASLNDSLINHCRSTKDPLIPALWGPLQKGEDPYAPVEQAGCCSSDVELVSRLLGNTRTTLSAILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MP68</accession>
    <name>A0AAJ8MP68_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_102518</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058674.1">
        <property type="nucleotide sequence ID" value="XM_070202573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MP68"/>
    <dbReference type="GeneID" id="30171238"/>
    <dbReference type="KEGG" id="kpin:30171238"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF9">
        <property type="entry name" value="AMINO-ACID PERMEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC68588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="538" mass="58117" checksum="1762FC32339A7CC6" modified="2024-07-24" version="1">MGDIEKYSEGNENSVPQLNDGTLNHGDNSNGSSLGKGSVDDEVLLAKLGYKSEFIREFGNLETFSFAMSMTASIATTFTTPLTYGGVASVVWCWLAGSIMNISLGASIAEIVSAYPTAGGLYTASAALVPRAYRPIVGWVTGYLNILGQVAGVASTEWGLSGMILAAVVICRETYEIKVWHQFLLFCALLIMHGFLNSLPTAGLARLTRYFVFINIGSAIIIIITLLATTPRSEMHPGSYIFTETINGTGWPNNGLAFMMGLLSVQWTMTDYDAAAHISEEVHRAAIAAPVAIFVAVLNTGAIGWILNIVLCVTAGDVSALPGPSGNAFLGIMYLRMGKAGAIVLWSFVCLIAAFTVQTALQANSRTVFAFSRDGGFPDRGLFGRMNKKTRTPVISVWVVVFISALMGVLAFASLTAVNAIFSMCAVALDLSYLIPVVCRRIFDGHEEVKFTPGPFYMRGWGLYVNIVMTVWTLFEVTILAFPASYPLTWDTFNYSAPITGAVMALSLIWYFAAGRRYYDGPKSNLSTEQKVAVQPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MQR0</accession>
    <name>A0AAJ8MQR0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_103881</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC69937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058947.1">
        <property type="nucleotide sequence ID" value="XM_070202846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MQR0"/>
    <dbReference type="GeneID" id="30172915"/>
    <dbReference type="KEGG" id="kpin:30172915"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF83">
        <property type="entry name" value="ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="101"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC69937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="688" mass="75225" checksum="F719727B2B2D60EC" modified="2024-07-24" version="1">MAPRKNKEAASWEVDADKPKPEGETRIRRAYCVKDLVTQPAPGIDTVHDVMLYAAKTHGSKKGFASRDIEKIISEEKEVTKMVGGKPTKQKKTWNYFKLSAFDWMSYDEALQRVKEIGAGLRALKADDKREGDKFFNIYGQTSRNWMLVAQACAFNAVPIATAYDSLGPDGLEHSLNETEVYGMFTNADLLGTLVKVIEQCKSVKLIVYDGKSEDGAVEKVKAIRDDIKLIHLDEVIKIGREKPVESIPAKAEDVYCCMYTSGSTGTPKGVLLTHRNVVSAIGSVWTLLYEYLTTKDTYLAFLPLAHILEFVVENSFIFAGLPIGYGRVKTLTDASVRECKGDIAELRPSILVGVPAVWELIRKGILSKVDTAGSLKKSIFNFALGAKQTANKYGLPLVGGLTDKIVFDGVRAQTGGRLKIMFNGGGAVSKSTQAFLCTALVTMIQGYGLTESTAMACILNPAFMQYGAVGGPVPAAEIKLVDSAEAGYFSTNELPQGEIYVRGPAIFKGYYKRPDLDEESFTKDGWFKTGDVGQWNKDGTLSIIDRLKNLVKLAGGEYIAIEHLESIYKSCPLVANGAIIANGEHNNPAMVVVAHPTNLPAFAKKNGLGDGEDLEHLTKDERVVDAALKELNAVGKKAGLKGLELLEAIVLVDDEWTPESGFLTAAQKLQRKLISQHYEDRIKAVYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MTG8</accession>
    <name>A0AAJ8MTG8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_107276</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC73309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059588.1">
        <property type="nucleotide sequence ID" value="XM_070203487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MTG8"/>
    <dbReference type="GeneID" id="30173548"/>
    <dbReference type="KEGG" id="kpin:30173548"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="266"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC73309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="501" mass="56175" checksum="2172B68D0F3F0AFB" modified="2024-07-24" version="1">MSKRPNSFNDKSPTKEEEERSKPKPRIKSYGMNLLIRSDENSSSSSTNSLDYNVIKSQLNLEENGNEIEKKQLDLISINGIASPPPKWLPTLPISSYNSIFSSSSSSSSFDNLPFLQQPSPLELIDSHIENHLSADSQNSQSGNYKSEITSPSISSSNVSTSPPLTPDSQYLPHPLGMNGFASSTGGGLPSPTGSTFTFTSSMQNAIFREDEGRLYNATQDDYGLPADNEEIQRLDIQHHAMRLLFGGNYLAHVGEHLRRNSALGKDMRVLDLGCGTGTWCLEMSREFPEAEFIGVDLVPIQPDNLPNNCSFMIDDITNGLSYPDGMFDLVTGRLLVMGLRDYPSILQDIARVIKPGGMYVATEPDIDLILDNGSVNKDMKGWKTWERGLQKAMKTRGTDPHLATKLYRYFTESGVFNEINVNRVNWPLTPWSKEQKQRNVGTVMIRDVRQFPDTSRLLIIDAAGISPNDYDRIKVKFLQELEMNYKISWHLWTCWGKKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HSJ7</accession>
    <name>A0A1B9HSJ7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_07721</name>
        <name evidence="2" type="ORF">I206_103772</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700118">
        <property type="protein sequence ID" value="OCF46244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC69829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007463.1">
        <property type="nucleotide sequence ID" value="XM_019159411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HSJ7"/>
    <dbReference type="STRING" id="1296096.A0A1B9HSJ7"/>
    <dbReference type="GeneID" id="30176090"/>
    <dbReference type="KEGG" id="kpin:30176090"/>
    <dbReference type="OrthoDB" id="2011702at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCF46244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC69829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="565" mass="62127" checksum="3153E6246F345E19" modified="2016-11-02" version="1">MAPSLLYHAINPNLYPTNTENETLLVVRFSGPVRISDIRIIPEGVESLTGPGTTYPLTFTGRILLNVSPSNPINALASTTIEVTPSENALNYPMNMPAGVTTRMMMLYSPAQKLTISIYGYSGGSLDTPIEPILADSLRLQPSIIDTKQLQKEDPNWLHTWCGDSPKSLLNLLDETTSPQILQRALDCLSLLNEIQPIFPLFLEDPVALTFFLSQPSNLRDTILSNPKYAIHPSVLPLLPSNHPLQILDQPSKSEQHLQAWKNLSLGLGPLMILSNADQEELLRIEDGEEKSNVVRLIELSNDELGRTHLEKNIEAILDILNHPFKDKSLNIYLSKYLPKLIVCSNMKGSKRELAIPSEYSEDVIRSLSAIRGEIIDGNSTKRICDQLALKYLKHLDNDHPLKRVFVANSFQTSPTHFGVGNNADIRRLNRLSNALDKSILGKDFEFSSLIHQITPSELISIISPELYSSLSTSRKPPFNVIPSVQIDLEQGTKSFAGKVYNQHEFRQDRDSPLSSTGLGISGMSGLGVGVGVGINTGGLGIGSLGGSGRAASRHVDSYTMVQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HSP4</accession>
    <name>A0A1B9HSP4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GST C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_07784</name>
        <name evidence="11" type="ORF">I206_103831</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700118">
        <property type="protein sequence ID" value="OCF46303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC69888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007522.1">
        <property type="nucleotide sequence ID" value="XM_019159470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HSP4"/>
    <dbReference type="STRING" id="1296096.A0A1B9HSP4"/>
    <dbReference type="GeneID" id="30176153"/>
    <dbReference type="KEGG" id="kpin:30176153"/>
    <dbReference type="OrthoDB" id="5835136at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03193">
        <property type="entry name" value="GST_C_Metaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019564">
        <property type="entry name" value="Sam37/metaxin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF41">
        <property type="entry name" value="FAILED AXON CONNECTIONS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10568">
        <property type="entry name" value="Tom37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GST C-terminal" evidence="9">
        <location>
            <begin position="165"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="318"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF46303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC69888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="402" mass="45642" checksum="B17348CEB20AFDED" modified="2016-11-02" version="1">MSNPPILLLSTPTLGDLPASDAESLYLASYLQIACPGRWAITTAQWGDNGGKLPYITHLGHHIRQSHLNNLHLVQDPDEHLSRKEKVDIECWKAYIEQNVVDLTNHTYYSLPPNYPDLLAKYQFKDLKFPESQYIPQRLRSIIKSRLQHVGLWGLGGLNSGDAADEDRQRLDEAFVVGPAGTLAPRAWSGWTAGRDMEERRKQWGEKELENTIKRVFDPLVRRLDDKSYFFGDRPSTLDLALFAQLTFMLTPALPNPLLPNLIRSTYPSLVAHHDRLFSLLFSNSYVSIPRTNDTPTSQKSYLESITSFISAPFSSSSEERNQKGEKKEKKSDQEKRFERGRWLWFTGATVAMIGYLLTSGMISIEFGSGKDDEEVYEDEEVPEESVGKEVIFVEEEVGNAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HSQ3</accession>
    <name>A0A1B9HSQ3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3',5'-cyclic-nucleotide phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_07790</name>
        <name evidence="3" type="ORF">I206_103837</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700118">
        <property type="protein sequence ID" value="OCF46309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC69894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007528.1">
        <property type="nucleotide sequence ID" value="XM_019159476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HSQ3"/>
    <dbReference type="STRING" id="1296096.A0A1B9HSQ3"/>
    <dbReference type="GeneID" id="30176159"/>
    <dbReference type="KEGG" id="kpin:30176159"/>
    <dbReference type="OrthoDB" id="258495at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004115">
        <property type="term" value="F:3',5'-cyclic-AMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047555">
        <property type="term" value="F:3',5'-cyclic-GMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006198">
        <property type="term" value="P:cAMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902660">
        <property type="term" value="P:negative regulation of glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07735">
        <property type="entry name" value="class_II_PDE_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000396">
        <property type="entry name" value="Pdiesterase2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28283">
        <property type="entry name" value="3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28283:SF1">
        <property type="entry name" value="3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02112">
        <property type="entry name" value="PDEase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="358"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF46309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC69894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HT52</accession>
    <name>A0A1B9HT52_9TREE</name>
    <protein>
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            <fullName evidence="2">feruloyl esterase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_07678</name>
        <name evidence="12" type="ORF">I206_102308</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.1.73" evidence="2"/>
    <dbReference type="EMBL" id="KI894017">
        <property type="protein sequence ID" value="OCF46444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007663.1">
        <property type="nucleotide sequence ID" value="XM_019159369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HT52"/>
    <dbReference type="STRING" id="1296096.A0A1B9HT52"/>
    <dbReference type="GeneID" id="30176047"/>
    <dbReference type="KEGG" id="kpin:30176047"/>
    <dbReference type="OrthoDB" id="424610at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043595">
        <property type="entry name" value="FaeB/C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38050:SF2">
        <property type="entry name" value="FERULOYL ESTERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628124" description="feruloyl esterase" evidence="10">
        <location>
            <begin position="21"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCF46444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC68383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="352" mass="39412" checksum="EC8608C77B10CD2C" modified="2016-11-02" version="1">MFSAFKLLTLAALKATTIFSIPLEDDQLIFNPSLSSIDTEFPSLKLSNPPKGHINRTLPSGREYVLFVPDEYDHKVEHPLVLSFHGAGGNSSRQEILTQLTKPELRIDNKPFLSAFPQGVDNTIWGMKHIWRGAPYANQSVDDVQFVKDILKDISLNYTLNPLRYYASGKSNGGGFTSLLSCLPDTSKLFAAFSLISPALYQEALSFSGCLPSRPIPILHSHGIEDDDTPFKGRSRSENWLFGPEPNVNNFRKRWALRNGHPPSTLTSKKNKLPKPNEINFPYKNVTEEKWTLGKAEIIGLSIGGLGHSWPSTEGLDLAGRPNNFANFNFTSQHLVQFFSRHTLPEEFLEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HTF5</accession>
    <name>A0A1B9HTF5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome b-c1 complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Complex III subunit 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_07406</name>
        <name evidence="13" type="ORF">I206_106705</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with cytochrome c oxidase (complex IV, CIV).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UQCRQ/QCR8 family.</text>
    </comment>
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        <property type="protein sequence ID" value="OCF46553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC72741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019159100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HTF5"/>
    <dbReference type="STRING" id="1296096.A0A1B9HTF5"/>
    <dbReference type="GeneID" id="30175775"/>
    <dbReference type="KEGG" id="kpin:30175775"/>
    <dbReference type="OrthoDB" id="6683853at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome b-c1 complex subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.210">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyt_bc1_su8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036642">
        <property type="entry name" value="Cyt_bc1_su8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12119:SF2">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12119">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX UBIQUINONE-BINDING PROTEIN QP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02939">
        <property type="entry name" value="UcrQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81508">
        <property type="entry name" value="Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
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    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCF46553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC72741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="119" mass="13506" checksum="2B238E5FCF3578D9" modified="2016-11-02" version="1">MRPSAPAQSGMPGPKTYIGWWGDMGSLPQKGIKTYGVSPYRQRAMAGALNGYIFNGFARLMNHLPYVAPPALFFYGVYYWSKSKYEYFNSKQGHYDNLIKEGVIKPGQYERPTVEPMSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HTQ8</accession>
    <name>A0A1B9HTQ8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_07511</name>
        <name evidence="4" type="ORF">I206_106598</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894016">
        <property type="protein sequence ID" value="OCF46658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007877.1">
        <property type="nucleotide sequence ID" value="XM_019159205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HTQ8"/>
    <dbReference type="GeneID" id="30175880"/>
    <dbReference type="KEGG" id="kpin:30175880"/>
    <dbReference type="OrthoDB" id="2564951at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
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        <location>
            <begin position="304"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="334"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF46658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC72634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="445" mass="48321" checksum="645312D9A4C16556" modified="2016-11-02" version="1">MAPPTPLSPTLTFALPPLPLIPTSPPLSLPILDKRQTYVTLSVTKNSTDDSSSNTSSSSGFPIKIAIPALIGGMALALAGFGIWLWWTRKVKRERREAWEARQRRKRRQQQNQSGRPSVSSSTRTPPSSGKKSPINEKGFIPPVPALPKHAATQDPYKERGYGYSELSQPPQQLNQVENGGGAFGYSTQPTLDQQQYSYDQYGQPLLQQQQQEQQQGYDPRQVYGHSRAKSNDSSNPSNPFSSTNSAVPDLPPSQEESSKISSPAPPRNEKSSKRAQARMNLADSAAANASVDPNLRHQPKKPSPLALAKAAEAAQYNHDQKMEHLAPPNNLPSYSSGGNIDNSIGGNRATSGEWGVALGSPNNDGNFSTNVQANQNQRYSISQDPYAPDNQRGKSGMYAQDPYAAYHGNVDEGDQDDDVYHKAAEGMGLGNGGNNTPKKSSRWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HTU8</accession>
    <name>A0A1B9HTU8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_07546</name>
        <name evidence="3" type="ORF">I206_106563</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894016">
        <property type="protein sequence ID" value="OCF46691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="37"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF46691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC72601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="318" mass="35847" checksum="D0E448228CFE635B" modified="2016-11-02" version="1">MTLKRASTPSDENVSNAKKAKTPVDIEYDEGYNDPEADITLITSDGVYFKVHSFVLKASSIVFRNMLAVGNEDNTEVNLTDPDFENSNTVSTFLDACCGKAIPEPIDLYKSDDTDEIEAYSDLIKFARKYESNLVLSQLSSLLYKWQYSKLISPFGIFVIAYNMESPDLAAMAIRSCGGRTWALSDTTDEAKAVATDRLRTVNPTTRVCLLDPSGMSEAQLDEMPSPYRWALIRATHNQINEKELSKTDWKKVSNDFLHLIKMSKNYKEREESSNEDRITPPGVDLSGQFKVDFLMFVRHLKDSKFGAVEDRAFSCML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HTZ0</accession>
    <name>A0A1B9HTZ0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C-8 sterol isomerase</fullName>
            <ecNumber evidence="8">5.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Delta-8--delta-7 sterol isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_07117</name>
        <name evidence="11" type="ORF">I206_106315</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 8">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ERG2 family.</text>
    </comment>
    <dbReference type="EC" id="5.-.-.-" evidence="8"/>
    <dbReference type="EMBL" id="KI894015">
        <property type="protein sequence ID" value="OCF46730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007949.1">
        <property type="nucleotide sequence ID" value="XM_019158811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HTZ0"/>
    <dbReference type="STRING" id="1296096.A0A1B9HTZ0"/>
    <dbReference type="GeneID" id="30175486"/>
    <dbReference type="KEGG" id="kpin:30175486"/>
    <dbReference type="OrthoDB" id="347124at2759"/>
    <dbReference type="UniPathway" id="UPA00768"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006716">
        <property type="entry name" value="ERG2_sigma1_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10868">
        <property type="entry name" value="SIGMA 1-TYPE OPIOID RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10868:SF1">
        <property type="entry name" value="SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04622">
        <property type="entry name" value="ERG2_Sigma1R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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    <evidence type="ECO:0000313" key="12">
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</entry>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Murphy C."/>
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                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
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                <person name="Nusbaum C."/>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
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                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        </source>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
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    </evidence>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
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                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
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                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">CBS 10737</strain>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
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                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the eukaryotic-type primase large subunit family.</text>
    </comment>
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        <property type="protein sequence ID" value="OCF47158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC68054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_019008377.1">
        <property type="nucleotide sequence ID" value="XM_019158631.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A1B9HV74"/>
    <dbReference type="STRING" id="1296096.A0A1B9HV74"/>
    <dbReference type="GeneID" id="30175305"/>
    <dbReference type="KEGG" id="kpin:30175305"/>
    <dbReference type="OrthoDB" id="421393at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA primase large subunit"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.20.930.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058560">
        <property type="entry name" value="DNA_primase_C"/>
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    <dbReference type="InterPro" id="IPR016558">
        <property type="entry name" value="DNA_primase_lsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007238">
        <property type="entry name" value="DNA_primase_lsu_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537:SF3">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04104">
        <property type="entry name" value="DNA_primase_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26466">
        <property type="entry name" value="DNA_primase_lrg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009449">
        <property type="entry name" value="DNA_primase_large_subunit"/>
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    <dbReference type="SUPFAM" id="SSF140914">
        <property type="entry name" value="PriB N-terminal domain-like"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="8 10 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 10" id="KW-0639">Primosome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA primase large subunit C-terminal" evidence="12">
        <location>
            <begin position="306"/>
            <end position="483"/>
        </location>
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    <feature type="binding site" evidence="11">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
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            <position position="394"/>
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        <ligand>
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            <position position="411"/>
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        <ligand>
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            <position position="455"/>
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        <ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00010564"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
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            <dbReference type="ARBA" id="ARBA00022515"/>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCF47158.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC68054.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="511" mass="58985" checksum="929AD4E38445676D" modified="2016-11-02" version="1">MFRPSTRHNIPSSSSNPALEVKLNKRQSGIGSSGNGGPSSRYPYRLNFYERPPTLDITLEEFETFAIARLRVLSQIESLSHRSLPFAQLQSSITNYTKQHLLLSSNTARNANLDEERRKDEIGHWVLRLSFCRSPDLRARFVRSELALFRNRFETDDVNERAQFLRSLEFDWQIVDENEKMRYEKELRNCMWEKKDDAFRSESWFKVPWYTVPDLVGSRRVFIRAGMAYVPQSLQISLVLQAFASRLEKALELTAKNLPRLDEDDRLGPVIDHLASSFLSGVASSDYQSSDSEGAQGVVTAEMVDDVARKHFPPCMRNLYDRLKRDHHLKHFGRLQLGLFLKGVGLPLDEAVVFWRRMYGATMSDDKFNKEYKYNIRHSYGQEGKRTNYPPKSCQQILTQNQPGTQDSHGCPFRHFSPENLSSFLSNTYPQIDRSSLEMKDILDSVKNTHYHVACTRVFELTHGIKKGDGLGDGESVAHPNKWVDKSRELEKDIIDRIKNKEDSDEMMIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HVC0</accession>
    <name>A0A1B9HVC0_9TREE</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_06991</name>
        <name evidence="3" type="ORF">I206_101918</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_019158686.1"/>
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    <dbReference type="KEGG" id="kpin:30175360"/>
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    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF47213.1"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="492" mass="53176" checksum="4D8C4BCE13642FC7" modified="2016-11-02" version="1">MSSARDEADLPPSDQRVEELPDSPPPTTGGNGSSSSSNTRPSMTNRSADESSSHVSSSDKPRKRPSFFSSSESSRSKPKTSHPPPPTVEDEYDEYRNTEGSSSSSSDSERGRGRARSRSADHGQGHPDSMDTSPPDAYKPHTHRDQTPFPTNRKATNKGGGSDDDIYMSGAIQSHSDDSPSDSSRRNRLRKKKKGRSTGFSKIFEPWTHANMAYQPYQPYQPPSVGDTAFPSFNGPNSMYSGYGGMPSTSISPWGPSTNNSYTGMPYSNGSVPFNQGLPTREMFAGWNPDDAVRAISSFQADWEAQNEPLVFRLTRLNVVRKAKEAAGPEQAPWLKTTTSTANPDPIASPFAQLGSGANSIWNPSMMGTNQSSATPFERKIPFGGTEITVPAGWTPEQAIQQTLSSYGLSSPSPFNQTSPFSQASPSSQANPFSQASPFSQASPFSQTTSANDDRFGWERKIRITDPLTGRTGIATIPAGVSVQEVLSRVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HVE9</accession>
    <name>A0A1B9HVE9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Pyruvate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">I206_07021</name>
        <name evidence="18" type="ORF">I206_101888</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700117">
        <property type="protein sequence ID" value="OCF47243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008462.1">
        <property type="nucleotide sequence ID" value="XM_019158716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HVE9"/>
    <dbReference type="STRING" id="1296096.A0A1B9HVE9"/>
    <dbReference type="GeneID" id="30175390"/>
    <dbReference type="KEGG" id="kpin:30175390"/>
    <dbReference type="OrthoDB" id="3970464at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000019">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000024">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF30">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE ISOZYME 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="16">
        <location>
            <begin position="6"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="14">
        <location>
            <begin position="243"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="15">
        <location>
            <begin position="454"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="496"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="523"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="525"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OCF47243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="WWC67969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="619" mass="67235" checksum="C9335A3798284E3B" modified="2016-11-02" version="1">MSETIEFGQYVVERLKQAGVKQVFGVPGDFNLEWLDFVENDPDIEWVGNANELNAAYAADGYARVKGGLAVIVTTFGVGELSALCGIAGALAERVPVLHIVGAPSTKLQSKDSLLHHTLNLPGSFTTFSTMSAPLSCSQALLNEIAPKTPTTWTEAFDKTLTDVLEQCRPGYVEIPTDAFHHKVSAAGLKEKLPHPHSAPPPESVAASISPQDAQASATTSLAAATTVAPTRAPSDEVTAYVVEEIAQRFKKAKKPVILVDACAGRFGMAGEVRNLVEGCGIRFFETPMGKSLLDEHHPLFGGCYAGANSLPAVREEVEAADFVLYVGALKSDFNSGSFSVNIDPKITIELHSFTTNIGYAAYPTTDIRHVLPDLLPAFKEVIQSRAASPQAGESAEQKVQAGRVESTVPEPKSNEIKHEWLWPRVGKWFADTDIIITETGTSSFGLTNVLLPSHSTYIAQILWGAIGWSVGACLGAAMAAQEDDRNRRTVLFVGDGSLQLTLQEIGTMLRRGVHPYLFVLNNDGYEIERQIHGETAKYNDIQLYDHQLLLPFLAGKKCQTPYQSYVVKTPSELNKLLDDEEFNKADRLRLIEVYMPRGDAPEGLIRQAKLTAEANAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HVH4</accession>
    <name>A0A1B9HVH4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_07050</name>
        <name evidence="7" type="ORF">I206_101859</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="F:FAD binding"/>
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        <property type="term" value="F:monooxygenase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <location>
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            <end position="380"/>
        </location>
    </feature>
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        <source>
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        <source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1B9HVQ2_9TREE</name>
    <protein>
        <recommendedName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I206_06248</name>
        <name evidence="14" type="ORF">I206_101780</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERT1/acuK family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Zn cluster transcription factor Rds2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
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        <property type="entry name" value="TRANSCRIPTION ACTIVATOR OF GLUCONEOGENESIS ERT1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PAS_13"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="12">
        <location>
            <begin position="114"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="158"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="335"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
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            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
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            <end position="80"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="180"/>
            <end position="194"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="11">
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            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00040903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCF47352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WWC67863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="619" mass="67853" checksum="FBA9E07DC364EA4C" modified="2016-11-02" version="1">MNDKTNKQYLAAIARMQERQMSWGRPTRSNSSGSISSTGDSSATSPHQLNLTALAPQQAGSSTSGGSASASLSGVTSSGRGRPKGKGKAKIKDENMHAGAGIIEHKARKKVAKACLACQKSHLTCDEQRPCTRCVKKGMADQCVEGVRKKAKYLLEGEERLAARPRQTSSSSPSPPITNLDQLQQQPQSSDPLSHQYSLLPNVTLPQQTQAIEPPRLPDDVWLSAPISQNDPSSIAGSGQINLNDPTRSWNTSMQTQSNSFTSNGNAANTEYQMLDSLFGDLSPIFPGLDSLNEAGRQLSMDGANASTVSSNVGYDQSWMNPSPATTNVAFKQNQNPFSVQPTPSSTGQSVSPATYSDLSPLNTTWQSQSLNQNQSWNGNNNTDSDQMTLDGMNQNQSLQDLQMQDQASANAPFQPPTPVQIGNGATPAEVYKTVVKPYDYTQGYHILMDYLTKNFEQHDTLRVARALASFRPSLIALQMPMSEEDEIFLEKSFQRTLIELEKLISYSATPTAVWRRTGEVCYANPEFCKLVDRSNADLYGSRTRTYIYELFSNPSVVSYWENFSVHAFENTTQNFFQPVGLSKPNTTLKCTGCITIRRDVFDLPSVIIGQFLPIPMDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HVW8</accession>
    <name>A0A1B9HVW8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_06311</name>
        <name evidence="8" type="ORF">I206_101722</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008631.1">
        <property type="nucleotide sequence ID" value="XM_019158018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HVW8"/>
    <dbReference type="GeneID" id="30174680"/>
    <dbReference type="KEGG" id="kpin:30174680"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF19">
        <property type="entry name" value="DUF895 DOMAIN MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCF47412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC67808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="486" mass="52724" checksum="6A8CE17E16B8AC3E" modified="2016-11-02" version="1">MSTQVESKKDLHADQGSNHNSHEVPSVEHVSYDVAPQPVKAHWFRSVTAQAIITGIASFLAPGAYAALAATGAGGLANVEIGNASVAVAYALIVPSALVSTGFLSKVGPRWTLAIGAAGYAPYAAALYTNSAYKNQWFLVVGAVICGLTSGLFWVSEGVIISVYSEPTRKGRMLAIWQSLYTLSTVIGGFINLFLNLDVKVKGGLKPKTYLVFVALNCLAPFASLLLSNPKQVQRKDGKAVTGIPDKGFWKETWLTIAELRDPKIIAMCFLWSQSLFIPSWTSTYLAKHFSVRVRGMSSIIKPTLTIIWFQVMGFYLDSKSTTIRKKLVYTWGFLHTVILGSCIWLLVLCVRQDKLAVAPAWDWSTPGFAAAWVPVALATAAQGTAYGYMYYVAGYVFPRGGDKARLSRIIATLRSAESGSAAIAFGINATKLSLHKTGYINIGFALFCVPCGLYILSYVWKQDKLGAFDEETVQVEKPAIAQETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HW09</accession>
    <name>A0A1B9HW09_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_06368</name>
        <name evidence="3" type="ORF">I206_101663</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008686.1">
        <property type="nucleotide sequence ID" value="XM_019158073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HW09"/>
    <dbReference type="GeneID" id="30174737"/>
    <dbReference type="KEGG" id="kpin:30174737"/>
    <dbReference type="OrthoDB" id="1734943at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF47467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC67751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="687" mass="72354" checksum="A4D1D239500405D5" modified="2016-11-02" version="1">MQALRTLPILNRPSRPSSPAPPTVQPTTAAGTPAATNIDGKPRSRSLSRQVAEKVSSLHATNGAIPAAVVAPSQPIGAPKKGLSPPGSRPITPRSTASPLPGVAAPNGATTETAGIQAKHMDVIGLRLNEVVNRACAGVDFKAKKGFKKGTGWSLGEAVVKELPFPPSDAYLIRAVLRTSVKALSIYTTRLETLLLPALTDPAFSSALNINAQAPAAHPLNPTQYFVLSVAHAAWETCEVLEQTLETGTWPRFVQETLRPVMDKLDLVVSKVIQPLMLGLKRDLVASLSKNEGTSPAGSKVIGLASIPAPTTAPTPAVTRELSNAPVSRLTKELSSGGTSRQLAIPPCLQHFANRVDGARRIFELVAAPCADDGEGWITGIMVAVIWKGMCIVSEKDLGGSPNRPPSPGSVAKALAGLGKEKEATPTVIAAPSLGGVTAKLTSSLSIIPSRSQSRPSSPPRGAQKLHPATHALMSLEGLVKRLVGGMVQPPAAPGTSVSQDPNAAEHIAREALHEALEALASFRIISNAMYKGGSCSSRILASARRLRDDIDDPVEDSLDDAMEDLPAVSLLTILLRQANTALTGLQSVNDEKTGTFKIRTPAEIWGWTLVEYERQVLSGFSAAEEWGRRYATAIKPDLERVLSQLATHSTGFSEKPTREVIEAVEWVKALGVACEARVGIKMGGCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HW42</accession>
    <name>A0A1B9HW42_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_06380</name>
        <name evidence="4" type="ORF">I206_101650</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008698.1">
        <property type="nucleotide sequence ID" value="XM_019158085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HW42"/>
    <dbReference type="STRING" id="1296096.A0A1B9HW42"/>
    <dbReference type="GeneID" id="30174749"/>
    <dbReference type="KEGG" id="kpin:30174749"/>
    <dbReference type="OrthoDB" id="73919at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47800">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47800:SF5">
        <property type="entry name" value="FER-1-LIKE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="6"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="458"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF47479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC67738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="550" mass="61785" checksum="3D84C7DEBD836293" modified="2016-11-02" version="1">MGDDKPAGGYDSTPLPKSTKPTYTVKITFHSATNLPIADFGDGSADPFILAQIKTSHKGRHPHDPYLRFRTKTIQKNVEPIWESNWIIDGIPSDGFDLSCRIYDEDPSDHDDRLGKVEIQTGNIDDKNWKGIIKQEYKVKKTGADLRAYSARWACHLIGRKKLHAKLTLSIEVIGKTNNDLGKAYTVNNFWWIHYSPLIGRLAGVKGKDDKGVEKYNFQANEIQLTGPVPDELYHRYVEFKTFVGGMFESTGLRGKVLNKALHHQHERIYNFDRQTKHGEFEFSPDGPPKDLALKFLEMCHFDQGGRIFTYVITLDGLMRFTETGKEFGIDLLSKHTMHSDVNIYIAWSGEFLIRRLAHPNQSPEDPDQSTHPAEEIPGGPPNDDPPRDAASYELIIDNDSGTYRPDKKLIPIFTKFLEKNFIGMKVRVMACDDEKLSKIKDSQRKTKQKEGERVVYGQQSSSDLSLNSQGGAGGSISSSDEEDLEARARAADENDDAEPQGVKGNLEKGFNAVENPKGTMNGLVDKAKGKTKEPSGKEEREKAENNDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HW65</accession>
    <name>A0A1B9HW65_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">VHS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_06402</name>
        <name evidence="10" type="ORF">I206_101628</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in the regulation of membrane traffic through the trans-Golgi network.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV700116">
        <property type="protein sequence ID" value="OCF47501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008720.1">
        <property type="nucleotide sequence ID" value="XM_019158107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HW65"/>
    <dbReference type="STRING" id="1296096.A0A1B9HW65"/>
    <dbReference type="GeneID" id="30174771"/>
    <dbReference type="KEGG" id="kpin:30174771"/>
    <dbReference type="OrthoDB" id="2018246at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14235">
        <property type="entry name" value="GAT_GGA_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16998">
        <property type="entry name" value="VHS_GGA_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.160:FF:000005">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.2, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000008">
        <property type="entry name" value="VHS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052653">
        <property type="entry name" value="ARF-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
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                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Nusbaum C."/>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Chapman S.B."/>
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                <person name="Goldberg J."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
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                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
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                <person name="Heitman J."/>
                <person name="Sun S."/>
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                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Abouelleil A."/>
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                <person name="Berlin A.M."/>
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                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Wortman J."/>
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    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
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                <person name="Gujja S."/>
                <person name="Hansen M."/>
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                <person name="Imamovic A."/>
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                <person name="McCowan C."/>
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                <person name="Pearson M."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
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                <person name="Zeng Q."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
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    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042123">
        <property type="entry name" value="Zip3/RNF212-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22663">
        <property type="entry name" value="RING FINGER PROTEIN NARYA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22663:SF17">
        <property type="entry name" value="RING FINGER PROTEIN NARYA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="225"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="346"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="163"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="414"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF48276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC73839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="423" mass="47993" checksum="A903B39ACBB8CE6F" modified="2016-11-02" version="1">MSPKSRLPPIKAKGLKFGSGTSSGPSSVGNDSKEEKKKEEEGSLPFLDNVCCNLCNESFFDGIAKSKIYWLTTCGHIVCDDDEHHHKEGTCTVCGKTKIHAVSMEQGNLQPAQEKFLYNPISRLKLLEAEIMKHIKVIQDDVTELSSLRTIYSFQEKQHKRTRLIYKQELDKERAETERLRNELDIHITENVELKQANKELQARLDMPPPPLPRSSLQASGVFETPRQSPVYGSGLNQSLPRIQEEEENSSAKRQRVEQNGFPPELLAPSTPIPTRPPSIIGGRIYQTPQPHHVDPHQSFDGYDPMLPRAGPSKHELERYRYNSTPVTAISPQVYSQGYIQGNGRITPMQGETPNVYRPYSAQGTHRRSEAQRQNYRFSQDGWSPNNLYDDNRQDYGSGEYDASDQPKVSLNLARKRPYPSQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HZ45</accession>
    <name>A0A1B9HZ45_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 16">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="11 16">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">I206_05338</name>
        <name evidence="22" type="ORF">I206_107118</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="22" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 16">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="11 16"/>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC73152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009778.1">
        <property type="nucleotide sequence ID" value="XM_019157060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HZ45"/>
    <dbReference type="STRING" id="1296096.A0A1B9HZ45"/>
    <dbReference type="GeneID" id="30173707"/>
    <dbReference type="KEGG" id="kpin:30173707"/>
    <dbReference type="OrthoDB" id="361536at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02658">
        <property type="entry name" value="Peptidase_C19B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14385">
        <property type="entry name" value="UBA1_spUBP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14297">
        <property type="entry name" value="UBA2_spUBP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000086">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000103">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000396">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000587">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016652">
        <property type="entry name" value="Ubiquitinyl_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041432">
        <property type="entry name" value="UBP13_Znf-UBP_var"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF664">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17807">
        <property type="entry name" value="zf-UBP_var"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016308">
        <property type="entry name" value="UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 11 16" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 11 16" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7 11 16" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10 11 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="20">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="UBP-type" evidence="20">
        <location>
            <begin position="157"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="19">
        <location>
            <begin position="307"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="18">
        <location>
            <begin position="598"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="18">
        <location>
            <begin position="660"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="697"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="751"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="202"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
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    </evidence>
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            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
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        <source>
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            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50235"/>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50271"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF48559.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC73152.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
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    </evidence>
    <sequence length="800" mass="88251" checksum="15C34ECE13100EAB" modified="2016-11-02" version="1">MSCSHISHIAPRLKSPTVGQQVHREECTLCFDGQDGPEGVLVCLECFNGGCFGEGRRHAYLHAEKTGHGVGVVIKRTRKERTKRDSTEPPNKKLAISAPKDEELYNISTSLRCLKCSPIGEAINSDDANVSSVIEGIMKALSSAQQSEVKAWEEEILPCEHTLTLEQVPLIQIGHVPTECSSCDLTSNLWLCLTCGFANCGRKQFGGVGGNGHALEHFHETGHMLGVKMGTVTPEGTADVYCYACDDAKVDPDLPKHLQAFGIEVLGQIKTEKSMTELQLEHNLKFDFSMTGDDGKELEPVFGKGLTGLKNLGNSCYMASVLQTLFSLPAYRSRYTSETASHHFQTCNKLPAECLECQMLKLADGLLSGRYSRRATLPPPSTTDFDENTEAPRFQEGIKPSQFKALIGKGHEEFSTMRQQDSEEFLQHLLGKLRSQAKSDSLPESLQPTRITKFGMEQRLQCTGCKKVRLQVEPVDLASLPVDATEKGIDEEGRKLFQEVELEKCIQQLCGDETIEGYQCETCDGKTTAIKSTRFKSFPELLVFHMKKFQLINWVPTKLEIPVNVPDTLTLDSFLSQGLQPGEEEMTVKSASDSALPEFNATAMSQLEAMGFPTNRCQKALLATGNSDAEVAMSWLFEHMEDPDIDAPIQVQTQSKSASEPSQDQINMISDMGFTPNQARKALRESDGNAERAIEWLFSNPGDPGEDVSTLPAGEGKDEKDENIGGSSDLPANYKLKAFISHKGPSVHSGHYVTTIRNPEGVDGKDGEWILFNDEKVVRAPERGGEEMRGKAYLYVFERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I026</accession>
    <name>A0A1B9I026_9TREE</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_05619</name>
        <name evidence="4" type="ORF">I206_106836</name>
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        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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            <taxon>Agaricomycotina</taxon>
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            <taxon>Cryptococcaceae</taxon>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">CBS 10737</strain>
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    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">CBS 10737</strain>
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    <reference evidence="3" key="3">
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            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
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    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="OCF48838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="OCF48838.1"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I075</accession>
    <name>A0A1B9I075_9TREE</name>
    <protein>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF48939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC71847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010158.1">
        <property type="nucleotide sequence ID" value="XM_019156356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I075"/>
    <dbReference type="STRING" id="1296096.A0A1B9I075"/>
    <dbReference type="GeneID" id="30172995"/>
    <dbReference type="KEGG" id="kpin:30172995"/>
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    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="69"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="852"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="858"/>
            <end position="883"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF48939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC71847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="883" mass="100618" checksum="5E9301220E7E711D" modified="2016-11-02" version="1">MAALRSLSVAGPGPQTWLYRLSLQSRFGCSLIPTAVSSARHSHNAVPRSANKSPGSTNNRPDRTQKTSSVNSKLLFANEGASENAVPNFDDVTLLGPPPEYPIQDDIDRLLQALRSSNLESAIKEWSYLWDLRCVSRLSPQDLEIISNSIRKILFGKNYPHLGRMALYQSAQFGHLKNMATEAASRGYGTGLYSFMLKLIGCGRPRDVVDSFEKCKQKMREFQGKNYEDLFSWDREKRLSARLEDTGDSQAGLQELMMSNIAAHTLLNDLDGTVLFSMLDSQIDFRSSATYNFTPIENALRACKSSHLYQQFRQNVDKFVLSLMCYHPNALVARITSLGTSRQYDKLYELYKKVLEASIGPDAFLKPKDLDDFGMSSRNIPLPPVIWLQFMKTFEWGSNIDKIIKMLDQDLPQRGLMPNGHFLSIAMLYMAIIAKRSGISPNKRSKARSMVDEYWRRLSVHNWHIEDGPFSRRIRTLSILSNLEPKLKSEITSLFEAAKDGHLGKIGPKTRAAFLEFYMRHTPNNQALGKAIQVFRVFPYDVENEGSGIDMAYAVFIRLLALGNWSSQEKLKAYKKVTTSLLATGYSLRTHLLGPLLSIQLQLLNIPMETMVNMTLDATVTPKHPEPGIQRWTKVLYGLLTKWTHASSPTLMESQAGLMILKRATSEQLYGVTRFREVGLFMSFLVPIAKATNLNVEQRQEFIDMALNIFPGGGKKNVSINMYMEIISHSFNRPDKAGYGEGIRRWKELRTLRDIPSIWWSKMLTLLIEHDKYDWALDLVRDAWNSKQVLATDGFWLRARSHGLTSELDLDDRLVIEQENLLRTQRTNQDSGKKWRSKEVIAFAEESVHDRDRTILEQAEENEVFEDDDDDEDSRWEAGEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I0M6</accession>
    <name>A0A1B9I0M6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arf/Sar family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_04705</name>
        <name evidence="8" type="ORF">I206_105885</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC71926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010237.1">
        <property type="nucleotide sequence ID" value="XM_019156435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I0M6"/>
    <dbReference type="STRING" id="1296096.A0A1B9I0M6"/>
    <dbReference type="GeneID" id="30173074"/>
    <dbReference type="KEGG" id="kpin:30173074"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001166">
        <property type="entry name" value="ADP-ribosylation factor D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCF49018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC71926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="184" mass="20202" checksum="2D1158C45E99FC8D" modified="2016-11-02" version="1">MGLTFSSLWSRLFSKRETKVLILGLDNAGKSTILYRITMGSVVASAPTVGSNHEIYDYKGVRFGLIDIGGQTSLRSSWSQYFTGTEAIILVIDSSDSTRLHMVKAELMKLVSDEQLKTSLLLVLANKQDLPISQGRLTPAQVSEALGLTDLREREWQIMGCSALTGLGLFEGMDWLVGKLESRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I161</accession>
    <name>A0A1B9I161_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_04962</name>
        <name evidence="3" type="ORF">I206_106137</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010492.1">
        <property type="nucleotide sequence ID" value="XM_019156690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I161"/>
    <dbReference type="STRING" id="1296096.A0A1B9I161"/>
    <dbReference type="GeneID" id="30173331"/>
    <dbReference type="KEGG" id="kpin:30173331"/>
    <dbReference type="OrthoDB" id="2241241at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025187">
        <property type="entry name" value="DUF4112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519">
        <property type="entry name" value="MEMBRANE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519:SF2">
        <property type="entry name" value="PH DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13430">
        <property type="entry name" value="DUF4112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF49273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC72177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="283" mass="32360" checksum="6BB3A54870999950" modified="2016-11-02" version="1">MASIISSIWPILTSYRPNAARDRQAQREKTPLRFGAFEATYRPPRWGVVRPQNDKDAQRLYNHIRTIAFWLDAAPVLADLGLPFRAGLDDIISLVPIYGDLLSGILQLYQVWLSFIFGVPKEILGYMVLNVFLDVIVGLIPILGDFLDNLFKSNLRNLLLLENYLLNQKKYNILLMPESNEFIPKPPKNKKFSTFWFGGGSKSTELNEEIERERINGKIKKTRRMKINEGEIFENFSKPYSTSTFTTSEQPDEIKPSGSTTGTRRRTRQSGNSDPDPVMEPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I1B3</accession>
    <name>A0A1B9I1B3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="6">3.1.13.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">I206_05017</name>
        <name evidence="21" type="ORF">I206_106192</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="21" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CCR4/nocturin family.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="6"/>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010545.1">
        <property type="nucleotide sequence ID" value="XM_019156743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I1B3"/>
    <dbReference type="STRING" id="1296096.A0A1B9I1B3"/>
    <dbReference type="GeneID" id="30173386"/>
    <dbReference type="KEGG" id="kpin:30173386"/>
    <dbReference type="OrthoDB" id="428734at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd09097">
        <property type="entry name" value="Deadenylase_CCR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000002">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 6 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF100">
        <property type="entry name" value="POLY(A)-SPECIFIC RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="16" id="KW-0804">Transcription</keyword>
    <keyword evidence="15" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="19">
        <location>
            <begin position="431"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="166"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="198"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OCF49326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="WWC72230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="779" mass="84832" checksum="565333F45EE759DC" modified="2016-11-02" version="1">MFYPHQQTSHASTGGGASKHHDSNGDSGGNRLGSGGGGGGWARHPSHPSFTPSGMPLPSPGGYPVLGSSAGGGGAYPPPGAGGHGHHQHSNHVHLHGHNQHHPTFGGSSNIGGGLGGPGNASHGPSYGGMSIFGGGGTNQQNSPPRGNEPSMPLTAFWQHQMLRAEASRLSSSPHHRARAAAISSRATNKPSAVIITDPNNRPASSQSNALNGIHRKQTSLSVTRADSDRGITPPPPPSDPSSTPGPDHADPANPAHPPAPNDKEEDRVSEPWTGLDLGGIRLKTLSTALFSFDHITSLYVNHNALTTIPSAISRLRQLTLLDATGNELTSIPPELGVLSKLKDLLLFDNNLTTLPYELGTLYQLETLGVEGNPLDDRLKKLIADEGTSGVIHFMRDNCPPGPEPPERHWIEIEPDVSSPSSGKQESFTVLTYNILCHSFAPGTTYSYTPSWALEWGYRKQAILNEIAQASADIVCLQEIDCEQYADYFLPELKRHGYEGQHYPRSRARTMSADEQKAVDGCATFWKSDRFQLVEAQVVEFNQLAISKTDMRTEDMFNRVMSRDNIAVVAALEFKASGARLLVANSHIYWDHRYRDVKLVQIGMLMEELEKIVENFSRLPAKLSADPEYNLGRGPPKYDRIQKGRDIPLIMCVDLNSLSGSAVYDYLSTGEIPPDHEDFMEHTYGTYTNKGLKHRLGLRSSCASFGEMRMTNFTPTFDAAIDYIFYAHKTMKVTSVLGDVDREYLDKTVGFPNTHFPSDHIPVFAQFRLKGSSDNLNGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I1C8</accession>
    <name>A0A1B9I1C8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PEBP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_05034</name>
        <name evidence="3" type="ORF">I206_106210</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="OCF49343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="WWC72248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_019156760.1"/>
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        <property type="component" value="Chromosome 8"/>
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        <property type="entry name" value="PEBP_euk"/>
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        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
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        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 4"/>
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        <location>
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            <end position="20"/>
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            <begin position="28"/>
            <end position="40"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF49343.1"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <sequence length="407" mass="45680" checksum="48FC43918EE48D1B" modified="2016-11-02" version="1">MSSRRAASRVICRASSSRQNSIPVFARAASSDASSSSSSSWQPALPAGQSPAYDAALSYLSSHQSKTLNKLDKLRSNVDKVNPDPELIRRIDQLEIEAYANDPAIRRKFRETGGKGEMSKTIYRWLAEQKWRKEGGLDLLMQRLLQMKIVPDVLPSLPPTFPLSLQSKNGNSTIEPGSVQLSSNFSSSPSIYSQLYYHPSESTNSTPNPEALHTLLMIDPDSPSHETHSFQQRIHYLKTDIPLSVISGEVNLTDSTIGKEILKWESPAPEQGTPNHRYIFLLFRQQSPSSPSITKRDNFELRDYLAENDLVIDDLVGVNMFRSKWSLEENEHINNVYISQRGIESGAPVYGKIPKEVKYGYPMSAKRQRKEEAREEAWDRAVVELEGLAEEVQGLTGLSEDTEKVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I1D1</accession>
    <name>A0A1B9I1D1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WEE protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_05043</name>
        <name evidence="10" type="ORF">I206_106217</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="WWC72255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_019156767.1"/>
    </dbReference>
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    <dbReference type="STRING" id="1296096.A0A1B9I1D1"/>
    <dbReference type="GeneID" id="30173412"/>
    <dbReference type="KEGG" id="kpin:30173412"/>
    <dbReference type="OrthoDB" id="5337378at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Cyclin-dependent kinase WEE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF189">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="849"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="1"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <end position="535"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="7">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="764"/>
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            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
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            <begin position="215"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
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            <begin position="268"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
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            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
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            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
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            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="820"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="879"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCF49350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC72255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1172" mass="124455" checksum="5EEE0ACB0773D992" modified="2016-11-02" version="1">MTARTSNHNGPVLQPSSTSTSNSTTNFKVPKAKGLNRPTTWFSNTSFGKSSSSSNSSSSSSSSAGGGSSSSSGVTARPNVGSPMANPFSVPSSSSFKSPFPSSKGKHKLSPSPSPSNKQDDDFVMISPVRPTYGLGVNLLPHQLGSGSGYSPSASPSRLADLQNSSSVSSSSPLEESPTPACGMASATARLKLVDDESPLRRVPGQSRSLARISKNTEDPRSVGKFEIRDNSSPLKFATNHLMSNQAEDEDDESPFLPPTPVMSNGLPAPPPQPLFPPIRTSQSQDSSTSGALFSGNNQKSDSSRIPRLSTSHPLRARAGTDAERPTLGSITKKAISLDQIPTTSGSSQDELFGSSSHIHVKKTRPASTFGPSGMSGLPASSSSNGRAHKRINSGEGLPHVANSASLSRSFGAKSLALSLTPNLGPLPDFSYSNSSLSSLSTANLTPPASAFSPAEPPIFEDVKPLQEAFEQSHNTVSRKFKPRDSGVSMGPDIDEEIRPKPKLMMPPPSVMKPTASGRPRRPAMLKRTSSMGDERSSIMDIETPGIGPMMNSGWPGKQANSFDFLGESGVGLGLGQNGNSSEKPSMPDTPVKKNAFTHSSSNPRGIGHSTSQPTLGSSGLEDETISNAPSEDSGKSDVSLSTRSSNMPPPSTKKLPPPSVMKKRPGSGVPQLTLTTSSSPEWATPMDTDDAASSPTVRIGSNAAQASAQAQGLKSLTLGGSGTSQVNRIGLLRRLSNGAVSESEEEGTPTKDGGDRATLAAARSNLITPTPSPKTSSSATLETTQHPKPPPSSMRNISTQGSGIMPRLSLPALPPSKPQQHRTLHHRQSHPTTSTVQLEEEDLFEKKFITLEVLGKGAFSTVVKVQDRHGEGLWAVKKARGVFDGIKDRLRHLEEVDILRHLSKTPCSHVIKFEDAWEQNRQLFIQTELCLGSLAFFLEEYGRVVERLDEGRVWKIIRELSDGINHIHSNGVIHFDIKPANILISSTGSLKIGDFGLATRYPRISPSEIFEGSGLGPGNTSLSTLGKGYGEKLEREGDRVYMPPEMLRGMFVMAADIFSFGLVILEVSTNICVPDGGSPWQALRSDDFSVVDLTPLSPALTDLITNCMKSIPEARPTVQQIIQHPVIKRAKMKSEKPALAPEDKNWLVDVLAGGFAASSVQEGEDVEMIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I1F6</accession>
    <name>A0A1B9I1F6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_05069</name>
        <name evidence="2" type="ORF">I206_106243</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010595.1">
        <property type="nucleotide sequence ID" value="XM_019156793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I1F6"/>
    <dbReference type="STRING" id="1296096.A0A1B9I1F6"/>
    <dbReference type="GeneID" id="30173438"/>
    <dbReference type="KEGG" id="kpin:30173438"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCF49376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC72281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="212" mass="24925" checksum="28F4BB32E09CC7BF" modified="2016-11-02" version="1">MTKKGFTKCDVCYEKFEIDLNKLLPLVERGEEILEKDSKGQLDYQDVKNDLINLIENLQKYIPNYSYPLFTLLRISTLTLTNNLNFSKTQKSEFEFEFDFELCLNYLRNTFEASKEIFSENHSNKTLILAEYSKFLNFSFNYIINNNNNKNKKFNQIEIISKKKNIINFLENSIKFTELSFGKLNKGGIVGKELNLILNDCKLELDNLNILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I1P8</accession>
    <name>A0A1B9I1P8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_05074</name>
        <name evidence="4" type="ORF">I206_106248</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010600.1">
        <property type="nucleotide sequence ID" value="XM_019156798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I1P8"/>
    <dbReference type="GeneID" id="30173443"/>
    <dbReference type="KEGG" id="kpin:30173443"/>
    <dbReference type="OrthoDB" id="2565019at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628342" description="CBM1 domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="362"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="469"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="493"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF49381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC72286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="538" mass="55058" checksum="8CCF6D98DE0DDA0F" modified="2016-11-02" version="1">MLKFFTLPYVLGSLLVLGVAQACFYYVYLESPYDYWDRYCKVGCVGMNNNDENFNQCCLPMTSGQTTPAVCATLSASCAAAGTVCPPWGSGVPTSNAPSTSGPPASYTPPAYKPRDVVPSTETVWVTETSTTPCASPSPTTNNAAVPTTSAPEECDCEGEDQGETSNAAAVPTGSAPAQGDAPSAGVQTDNRRRRRGLMIRDKCVCPTSTSASSVPSTTAPPPVTSNAAVPTSSSQCVCPTGSAPGQGDAAPEGFQGDRRDMGSNGECSCPGETGNAAVPTTSSSSSTPPTTTSSTPEGTEECECDCEEEGKTSNAAIPTGSTPVEGDTPSQGVSTDNRRRRGLKVRGGECVCPTSSSAAVPSTGNAAAPTTAPTEPKPCECAPSSSAPGEGSAPSRRGFMVRDNCVCPTTGNAAIPTTSAPGEGNANPDYSGSDNRKRNAPPSYFVGDKKSQLPGENFKFNKREVNPTQTVTSTTTITTDDCAMQTAPTTGETSVAAVPTTSAAPSPTGSAPSEGDINTTFIGGDNRKRSYGRWRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I209</accession>
    <name>A0A1B9I209_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">2-deoxy-D-gluconate 3-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_04086</name>
        <name evidence="7" type="ORF">I206_104336</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010783.1">
        <property type="nucleotide sequence ID" value="XM_019155825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I209"/>
    <dbReference type="STRING" id="1296096.A0A1B9I209"/>
    <dbReference type="GeneID" id="30172455"/>
    <dbReference type="KEGG" id="kpin:30172455"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000398">
        <property type="entry name" value="Probable 2-deoxy-D-gluconate 3-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF5">
        <property type="entry name" value="2-DEHYDRO-3-DEOXY-D-GLUCONATE 5-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="5">
        <location>
            <begin position="17"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCF49564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC70386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="279" mass="29602" checksum="3B0958EE9ABECC97" modified="2016-11-02" version="1">MSSSPSYIEELFGLKGKTALLTGATRGIGARLALALSKAGADIILIQRNDTNTKTKDEIISNGGKAEIVICDLSSSEQVSKLIPHITEELNKNLDIVVNCGGIQKRHPVENFPDSDWQEVLQVNLNTVFTITRDAGKHMLKSRGGVSGEDVPQGGVDGNPRGRGKIINISSLVAYQGGLNVVAYAAAKHGVQGIIKSFSNGWASKGVCVNGIAPGYIATDMNEALIADPVRSRQILERIPAARWGTPSDFEGAIVFLASKASDYVSGETLVVDGGWMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I287</accession>
    <name>A0A1B9I287_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_04137</name>
        <name evidence="5" type="ORF">I206_104286</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010834.1">
        <property type="nucleotide sequence ID" value="XM_019155876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I287"/>
    <dbReference type="STRING" id="1296096.A0A1B9I287"/>
    <dbReference type="GeneID" id="30172506"/>
    <dbReference type="KEGG" id="kpin:30172506"/>
    <dbReference type="OrthoDB" id="3199651at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="175"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF49615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC70336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="217" mass="23126" checksum="9AA6F3F5A8D6D855" modified="2016-11-02" version="1">MSTPTPEASGVRQRANKVKEEETENPASLSSNPNKKVPRNKPNVNPPFINTSMNKFLTYLVLSLALVLAFYIWRFVSWAHQAGGYWAVISGNHKSPISDAASSAASAASSISKYQKSSTTSVNPKSIVPKPTQAGQPEDDIQSQIYHLANSLGIKPAELSAAIRPLVDPSVPDPAAKAQQEAELLRAQVEAKAAEHKAEATQAEGGLMGILGEALLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I2A0</accession>
    <name>A0A1B9I2A0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vps72/YL1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_04181</name>
        <name evidence="8" type="ORF">I206_104241</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010878.1">
        <property type="nucleotide sequence ID" value="XM_019155920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I2A0"/>
    <dbReference type="STRING" id="1296096.A0A1B9I2A0"/>
    <dbReference type="GeneID" id="30172550"/>
    <dbReference type="KEGG" id="kpin:30172550"/>
    <dbReference type="OrthoDB" id="49520at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029525">
        <property type="entry name" value="INO80C/Ies6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013272">
        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31200">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31200:SF1">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08265">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="6">
        <location>
            <begin position="221"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCF49659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC70291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="272" mass="30019" checksum="578AE610C0D542B6" modified="2016-11-02" version="1">MDRAPKPPNRFGPRKSNTSTPVPGEEGIYIPTAADKLSYSEIPKPFKSLNFKSKLPSRTATTSTLIVKKNSKQILNLERERLSGGNGFLSSIHTAAKLRGEIIDITKNKKLTGSSSTSKQRGNISNLLKGRNLKNPNLKYQNQNQEQNLINSNTIEDENLLLNSGSTTPLIDQNEEDIESSSNLNNNENKGEITVNDLIPKKEIITYHTPTAPPSLLPPKKYCDITGLHASYTDPRTKLRYKGLDVWHVVRGLGPGGDQAYLSLRGAQTSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I2N6</accession>
    <name>A0A1B9I2N6_9TREE</name>
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        <submittedName>
            <fullName evidence="11">Zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_04290</name>
        <name evidence="12" type="ORF">I206_104134</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Acts as a protein folding chaperone for elongation factor 1-alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZPR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010984.1">
        <property type="nucleotide sequence ID" value="XM_019156026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I2N6"/>
    <dbReference type="STRING" id="1296096.A0A1B9I2N6"/>
    <dbReference type="GeneID" id="30172659"/>
    <dbReference type="KEGG" id="kpin:30172659"/>
    <dbReference type="OrthoDB" id="308464at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000001">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000002">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1040:FF:000001">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1040">
        <property type="entry name" value="ZPR1, A/B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.420">
        <property type="entry name" value="ZPR1, zinc finger domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004457">
        <property type="entry name" value="Znf_ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040141">
        <property type="entry name" value="ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042451">
        <property type="entry name" value="ZPR1_A/B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056180">
        <property type="entry name" value="ZPR1_jr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042452">
        <property type="entry name" value="ZPR1_Znf1/2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00310">
        <property type="entry name" value="ZPR1_znf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22794">
        <property type="entry name" value="jr-ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03367">
        <property type="entry name" value="Zn_ribbon_ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00709">
        <property type="entry name" value="Zpr1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="10">
        <location>
            <begin position="48"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="10">
        <location>
            <begin position="309"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCF49765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC70185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="521" mass="58161" checksum="BA8DC5046BFFA1F4" modified="2016-11-02" version="1">MSAASIPNEGEEQKQNFFPTLGDVADRTDALKGEDGETDEREMQEIESLCMRCHDNGTTRLLLTSIPYFKEIVVSSFRCDHCGHRDTEIQSAGEIQPKGVVYTVHLLTRADLDRQLVKSNWATLSIPDLQLTIPPGRGQINTVEGIIRDTVRDLNISQPVRRVMDPETGKKIDDMLEKLRNLINMEVEDGDDGGVGVDDEDVRKPSEAPLQEHEEQPFVPFSMVLDDPSGNSFFSFKDSPSDAQWNMRAYNRTFDHNVTLGLVAKPDELEEGGAVPLDEQHKLSSLEEFEAKRAKEGEVVPEEVFSFPSACSSCGHQLETRMQQVNIPYFKDIIIMAANCYACGYRDNEVKSGGSIADKGKRISLKVEDEEDLSRDLLKSDTAGLEIPEIDLHLQPGTLGGRFTTLEGLLNEIYTELSTKVFRTGDSLTSGIGQINNEGQQGERKFETFLKGLKDCISATKPFTLIIDDPVSNSYLQNLYAPDPDPNMIIEEYERTFEQNEDLGINDMVLEGYDKEAEGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I3T6</accession>
    <name>A0A1B9I3T6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_03449</name>
        <name evidence="2" type="ORF">I206_105650</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
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    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894010">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I3T6"/>
    <dbReference type="GeneID" id="30171818"/>
    <dbReference type="KEGG" id="kpin:30171818"/>
    <dbReference type="OrthoDB" id="2400485at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCF50131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC71692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="203" mass="22346" checksum="1AD9BDC5A0841241" modified="2016-11-02" version="1">MTSQSNTVSASSLGELHNDPSKLSYDPTLKLSKRHLEHAALVLDIFQGKGTMTKINNGFTEDSIYEDPVAIGHDRQEVAGQLLHISTVTSSTKTNKFNIIDLTSNVETETGSKRKVKADLIQVEFNHDLNFKIGPTYNLDTTLQIYSTEEGIVRLQDRPGDKIPDNGFAMALRKLNGVVAPKVAGVPQNQKEDAEKALKQDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I4E6</accession>
    <name>A0A1B9I4E6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sensitive to high expression protein 9, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_03711</name>
        <name evidence="13" type="ORF">I206_105382</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for the maintenance of the structure of the mitochondrial inner membrane. Involved in mitochondrial morphology. Causes growth arrest when highly overexpressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the SHE9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011609.1">
        <property type="nucleotide sequence ID" value="XM_019155455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I4E6"/>
    <dbReference type="GeneID" id="30172080"/>
    <dbReference type="KEGG" id="kpin:30172080"/>
    <dbReference type="OrthoDB" id="5595506at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008839">
        <property type="entry name" value="MDM33_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31961">
        <property type="entry name" value="SENSITIVE TO HIGH EXPRESSION PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31961:SF3">
        <property type="entry name" value="SENSITIVE TO HIGH EXPRESSION PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05546">
        <property type="entry name" value="She9_MDM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="510"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="49"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCF50390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
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                <person name="Young S.K."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Abouelleil A."/>
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                <person name="Berlin A.M."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
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                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
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                <person name="Cuomo C.A."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
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                <person name="David-Palma M."/>
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                <person name="Bowers K."/>
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                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
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                <person name="Cuomo C.A."/>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
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                <person name="Chapman S.B."/>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
    </reference>
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</entry>
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    <name>A0A1B9I4U7_9TREE</name>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Murphy C."/>
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                <person name="Roberts A."/>
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                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">CBS 10737</strain>
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    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Shea T."/>
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                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
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        <text evidence="3">Belongs to the translin family.</text>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
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                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
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                <person name="Griggs A."/>
                <person name="Gujja S."/>
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                <person name="Imamovic A."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
                <person name="Sun S."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
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                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC71198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011833.1">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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            <strain evidence="9">CBS 10737</strain>
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            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Pearson M."/>
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                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
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                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
        </source>
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    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC68504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="357" mass="42068" checksum="1EB2A6AAC9589919" modified="2016-11-02" version="1">MNSPKDTNRSTQSYTSVTTHSGRRGESLPTDSFFKLPVDVRSHTSSQAFGQTWCDHCRLAKKEELFTWGIIAYQTDREDPMATIDGCSVLENLALGEVQEKSIKEGIEWYWHPDCCDGYPCQGPIKYCEKMKRWSFTQKCVKHFPIKAPSECHPYMRGINPHRSEDSEEGTSQNELRGRVDLCPVVTAISHSTSHSDRHQNQQSVGTTPVAWTWLEPDAYCRDTMNHVKDDEQQINLDDVSMEHGEINVDRFSDMDDVFEDIRDEEMEELRKERDQARIRQAQMEERYHSEKMERKKIEIKYAKLQRRLYDDHQNYRRYLDELVKKDDTMDQKFRKQLCELELTMQMMENIARRTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I5T4</accession>
    <name>A0A1B9I5T4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_02931</name>
        <name evidence="5" type="ORF">I206_102580</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF50873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012092.1">
        <property type="nucleotide sequence ID" value="XM_019154689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I5T4"/>
    <dbReference type="STRING" id="1296096.A0A1B9I5T4"/>
    <dbReference type="GeneID" id="30171300"/>
    <dbReference type="KEGG" id="kpin:30171300"/>
    <dbReference type="OrthoDB" id="1065058at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052791">
        <property type="entry name" value="SSM1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438:SF1">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="268"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="365"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="456"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="601"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="602"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="636"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="668"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="728"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="755"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF50873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC68649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="885" mass="97809" checksum="2D602A8688C0F418" modified="2016-11-02" version="1">MQTKEIESPPANEKPNVPLRNRSVNAARKLTPLSGPNDNSLTTNVPSRPQPRKSLLGQVHVPSRRSSEPSPRNLQRDYFPVSPHTPASPEAIPSTSPLSWGADQPLGPDGFPDIFSEPTNWDDPITEEDWELRTETANGLEDADSPYASLETHYLRQITHYKNLLVRSQSSSSSSLHDLHSQLHYLRKLYHDLEAEHAQCGVKEKAKADEADFERRATEGLKNVMESTISDMDKNERIKLLGMIAEACHPSDINAQIAILEKYRKSRFDILSRVEEPIFVRILSLLDVKDILLLRNVSKGYNQLTRNDLLWKGLCRQLEWRDCEGEASLSHLYVTQAGSWEEMYKSLWKREQNWNSGTAQKVFLLKGHESYVTSLRLRGDVLISGSYDESIRIWHLPPLRTLTPAAIPQPLVIPAKSVSCLDYLPTEDVLVAGYHDVGRVQVWKKMAENWQLLHTLSGHLRGIRAVVINENHLVSAGADKALVVWSWRTGERIVRFGQQTNICIGIQLIHDYIVAVTVDGVIRTFSIRQREMMAQFKLSDIGRTLSGGSERQEWKAKMKDIGGGQGGVGMINWFEGQGRIMTCATREIIIRMSWEETEEVFSPVPSQSSSDSPATPSPSKRRIHNVSSPARALPATYTSTKLTSPLKPSTPLGPNPGKGNRRSVFDLSSRAESNSLSSPKPRFGSPLGRSAASNRSPGMPGHPSSEAALTPIGSKGQGGLGRASSPATQSSSPRESLSSSRRSSSLPQTSVNDITSEHDGRCKDMRRTVPLLTGPPKILEIIHAPDVEKGAIDVKGTRVVTSTRFAARSGANRHLYVGVSPSDTAGTNMIPVLGAWKDKSDLFDLQTPGKNPMSLVLDREKFVYGCTDGSIVVVGFQGNEHIADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I5U0</accession>
    <name>A0A1B9I5U0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translocation protein SEC66</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_02948</name>
        <name evidence="4" type="ORF">I206_102594</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF50888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012107.1">
        <property type="nucleotide sequence ID" value="XM_019154704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I5U0"/>
    <dbReference type="STRING" id="1296096.A0A1B9I5U0"/>
    <dbReference type="GeneID" id="30171317"/>
    <dbReference type="KEGG" id="kpin:30171317"/>
    <dbReference type="OrthoDB" id="73168at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="InterPro" id="IPR018624">
        <property type="entry name" value="Sec66"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28229">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28229:SF1">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09802">
        <property type="entry name" value="Sec66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
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        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF50888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC68662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="30143" checksum="570B38601294858C" modified="2016-11-02" version="1">MATSLVVPLAYISVMITALAIFSRVYRRRRAAEKTSFEPWFPKHPSRETYITLISASSSSSSSETPIPDSLLKSALLVRAITDVKRIWRLRDDKIALTQLSQKGLIGDDTMLRFSAAEKELEAEIVDVVSEANSFRQGWGQMIFATATEMAQAEKTRETVMNIPKIKAQEDKRIALRNKYLPGSVPPPLIQQVPIPPQAVTASGSGSGTSTPSPSANSSSGKVATPQKVPAASGSPALASSETVAPGSGETSKDGSPNPNTGSGSGSGTSTPSKSTPGKKKKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I636</accession>
    <name>A0A1B9I636_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_03051</name>
        <name evidence="10" type="ORF">I206_102698</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF50989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012208.1">
        <property type="nucleotide sequence ID" value="XM_019154805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I636"/>
    <dbReference type="STRING" id="1296096.A0A1B9I636"/>
    <dbReference type="GeneID" id="30171420"/>
    <dbReference type="KEGG" id="kpin:30171420"/>
    <dbReference type="OrthoDB" id="5571888at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140911">
        <property type="term" value="F:pore-forming activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050829">
        <property type="term" value="P:defense response to Gram-negative bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031640">
        <property type="term" value="P:killing of cells of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14810">
        <property type="entry name" value="bZIP_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051882">
        <property type="entry name" value="ATF_bZIP_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014739">
        <property type="entry name" value="Channel_colicin_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46164">
        <property type="entry name" value="ATF6, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46164:SF3">
        <property type="entry name" value="ATF6, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58096">
        <property type="entry name" value="Colicin Ia, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="291"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="110"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="181"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="227"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="247"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCF50989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC68764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="355" mass="39569" checksum="A154A3DA15116567" modified="2016-11-02" version="1">MNTIPITDEKSAAMAATWSPSWGSYLYQNFLVAGAAAPTPTLDWLNATSQQAHQTSLTGVNNVGVSMNNVNTSAMDYFGLPASLNSANISGTDWADNSASVIQIKTEVDESSYNDQQQRQRQLQQQQQQQRQQAQAGPSSFYPQFYFSQSGGINTSLLTQNQAQNAVQDYSPESTIDTVIPSLSSTSQRTSTDSVHIVDTSLTRSPSPISSLVISPHGSPALQSVKIKGRPRRGGKKRSHSILSDSEASHTHDEHDHDHDHEHEPEVPEGVERDGMIWGMKVEDYRALSARERKRVRNRISARTFRAKRKEHLTSLEHDLGAKDLQIKIANDEANRLRKEVAELRRKLAKYEKQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I646</accession>
    <name>A0A1B9I646_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_03044</name>
        <name evidence="3" type="ORF">I206_102691</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
                <person name="Sun S."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Alvarado L."/>
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                <person name="Dewar J."/>
                <person name="Goldberg J."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
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                <person name="Sun S."/>
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                <person name="David-Palma M."/>
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                <person name="Bowers K."/>
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                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
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                <person name="Heitman J."/>
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    <reference evidence="10" key="2">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
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                <person name="Imamovic A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="Zeng Q."/>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I6Z4</accession>
    <name>A0A1B9I6Z4_9TREE</name>
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        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
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                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">CBS 10737</strain>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Murphy C."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="5">CBS 10737</strain>
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    <reference evidence="4" key="3">
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">CBS 10737</strain>
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    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="5">CBS 10737</strain>
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        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012841.1">
        <property type="nucleotide sequence ID" value="XM_019154101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I7S3"/>
    <dbReference type="STRING" id="1296096.A0A1B9I7S3"/>
    <dbReference type="GeneID" id="30170706"/>
    <dbReference type="KEGG" id="kpin:30170706"/>
    <dbReference type="OrthoDB" id="2562493at2759"/>
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            <end position="48"/>
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            <end position="270"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
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    <sequence length="357" mass="40235" checksum="A120AD6B2F7B7E4D" modified="2016-11-02" version="1">MSLDISGMPAEQVEAIAKMAFGDNLGLKLGPVLLGPIFDAILYGIMIIQFQNWWTYCRPTERRVINYLTYYIMLAASSWTFMVIAYSMHNFVYNFGFYTTFLKMPYPTAFPSVGFGMSAAVQAFYVERTFRLNNRNIPLVILLIACILGELTAVIIIVVKCTKVSSELQAGDVIMEIRAWQCLTLATDFMITVSLAWGLWRAKTGWSHTDALVKRLILITLETQLAPTLVMLGFVIEMSIFPASTMGIFFDIMIPKAYTVGYLATLNTRVHLRRDQTASASGGKGDQTRSNAYHLGSGRLQQATVQVDTDTYVESYQLQAPKQGVNRDLMYEEESIENLDYAKNLSKRDLNQPNDKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I804</accession>
    <name>A0A1B9I804_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Solute carrier family 25 (Mitochondrial citrate transporter), member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_02405</name>
        <name evidence="13" type="ORF">I206_104865</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
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    </reference>
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            <authorList>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
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        <property type="protein sequence ID" value="OCF51690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="WWC70913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="1296096.A0A1B9I804"/>
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    <dbReference type="KEGG" id="kpin:30170774"/>
    <dbReference type="OrthoDB" id="44467at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071913">
        <property type="term" value="F:citrate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Mitochondrial tricarboxylate transport protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF4">
        <property type="entry name" value="TRICARBOXYLATE TRANSPORT PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5" id="KW-0677">Repeat</keyword>
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    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="12"/>
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        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
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            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
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            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCF51690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC70913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="298" mass="32037" checksum="8294A2AD0648BAFE" modified="2016-11-02" version="1">MSSITAKGKEKENPIASLLAGAVAGGTEAFVTFPLESLKTQLQFGALEGGKQLTPYQALKGTIQQRGFLGLYAGVTPVIIGNAVKAGVRFTTYDQFKSLLKDDQGKLTAPRSMLAGLGAGMSEAIIAVTPSETIKTKMIEDSKLAQPKFKGTSHAVQTIIKEEGWLGIYRGVGPVMLRQGANSAVRFSSYSTLKQLAQGSVVPGTQMPGWMTFGIGATAGVITVYCTMPFDVIKTRMQSLRAKTEYKNSLHCAYRVVTEEGFFKLWKGTVPRLGRLIMSGGIIFTVYEKTYPALSSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I856</accession>
    <name>A0A1B9I856_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent Clp protease proteolytic subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_02408</name>
        <name evidence="9" type="ORF">I206_104868</name>
    </gene>
    <organism evidence="8">
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        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec, and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).</text>
            <dbReference type="EC" id="3.4.21.92"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012912.1">
        <property type="nucleotide sequence ID" value="XM_019154172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I856"/>
    <dbReference type="STRING" id="1296096.A0A1B9I856"/>
    <dbReference type="GeneID" id="30170777"/>
    <dbReference type="KEGG" id="kpin:30170777"/>
    <dbReference type="OrthoDB" id="2017408at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009368">
        <property type="term" value="C:endopeptidase Clp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000001">
        <property type="entry name" value="ATP-dependent Clp protease proteolytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001368">
        <property type="entry name" value="PRK00277.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381:SF11">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF51693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC70916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="261" mass="28542" checksum="63FFCC2BEE02C1AA" modified="2016-11-02" version="1">MSRIATSLLRPALSVAGPSRLIPSRAFGFLPSLNDYTSQISSDPASNPVVRDSLVPIVVEQTARGERSYDIYSRLLKERVIFLGPVNSVDSTLLTAQLLFLEAEDPARPIKLYINSPGGVVTSGLAIYDTMQYISPPVHTFCLGQAASMGSLLLAGGEKGHRYALKNSSVMIHQPSGGAQGQATDIALHAKEILRIRSALTDIYADHCTKSDEARENARERFEKALERDYYMTADEAVNFGIVDKIVTRRGDGQITEEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I8I2</accession>
    <name>A0A1B9I8I2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mitotic spindle assembly checkpoint protein MAD2B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_02540</name>
        <name evidence="4" type="ORF">I206_105001</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC71048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013043.1">
        <property type="nucleotide sequence ID" value="XM_019154303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I8I2"/>
    <dbReference type="STRING" id="1296096.A0A1B9I8I2"/>
    <dbReference type="GeneID" id="30170909"/>
    <dbReference type="KEGG" id="kpin:30170909"/>
    <dbReference type="OrthoDB" id="21254at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF10">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="2">
        <location>
            <begin position="13"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF51824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC71048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="241" mass="26496" checksum="A21822A915AE95E8" modified="2016-11-02" version="1">MATTAQQPGLSYKDIADAIISFLEISLHTILYLRSVYPATTFSRRRAHGVPIYQSRHPQVRAYITTVITALAPEIHNGKLRRMTVVIKGVEDGLPRERMIFDMGYLAELEKLREGRGTEVGLIGAPNADELGLMLRGFLIKLNALEGQLLDNKGETTFAVVIETNDSLEPSTNINEDGSVPPWIPALAADTLRPPASQDLEGCTEKHEPLLNVKAVETGVIDIRLMVQECVAKTGVDRLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I8P4</accession>
    <name>A0A1B9I8P4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">High-affinity glucose transporter SNF3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_02600</name>
        <name evidence="13" type="ORF">I206_105060</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC71107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013103.1">
        <property type="nucleotide sequence ID" value="XM_019154363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I8P4"/>
    <dbReference type="STRING" id="1296096.A0A1B9I8P4"/>
    <dbReference type="GeneID" id="30170969"/>
    <dbReference type="KEGG" id="kpin:30170969"/>
    <dbReference type="OrthoDB" id="2241241at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000646">
        <property type="entry name" value="High-affinity glucose transporter SNF3, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF91">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="7"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="482"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="484"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="506"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCF51884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC71107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="521" mass="57274" checksum="954F6FD1D1008E08" modified="2016-11-02" version="1">MKKSIIFCLFAAFGGWLFGYDIGYISGCLIMPDFIHQIQGPDATAITSHNQSIITSLLSAGTFFGAILQAFTSDRLGRKGSILFWSVIFTIGVVVQVSTFGLAQLTAGRFVAGLGVGALSAIVPLYIGEAAPKKLRGTLLVLYQVQIISGLFLAYIVNLGTHHIANSASWRIPIGLQLIWGSVLMGGSLLLPESPRYLLGKGEEKKAIKAIAMLNDCGIEDKLTEEVLNEMSYAVKIENEGGKAGWLECFSTRSRMWKRTLNGCMVQFLQQLNGQNFYYYYGPVFFEAAGTGLDAYSIQAILGGISLVMVLPAMWTIEHVGRRKSLLIGSLGQAVCAIIAGLVGHFYTDVGGVSESKRQLGGNIMIAFAVFHVSLYSMFWGPTPWVLMGETFPLRVRSKCIALAAATNWLWNFLLSYFSPLIADDIGPLILLVFCGCLVFAFVYVFFMIPETRGISLEEVDELYRTKVHAWQSNSWVPSAQRNDTIEKMEGDPRPSESTYVPPQVTEKKVTEQHVENVPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I957</accession>
    <name>A0A1B9I957_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="11">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Transfer RNA methyltransferase 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TRM8</name>
        <name evidence="13" type="ORF">I206_01340</name>
        <name evidence="14" type="ORF">I206_103657</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10 11">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms a complex with TRM82.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="11"/>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013275.1">
        <property type="nucleotide sequence ID" value="XM_019153114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I957"/>
    <dbReference type="STRING" id="1296096.A0A1B9I957"/>
    <dbReference type="GeneID" id="30169709"/>
    <dbReference type="KEGG" id="kpin:30169709"/>
    <dbReference type="OrthoDB" id="47276at2759"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106143">
        <property type="term" value="C:tRNA (m7G46) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine(46)-N7)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000060">
        <property type="entry name" value="tRNA (guanine-N(7)-)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03055">
        <property type="entry name" value="tRNA_methyltr_TrmB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025763">
        <property type="entry name" value="Trm8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00091">
        <property type="entry name" value="tRNA (guanosine(46)-N7)-methyltransferase TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="3-DEOXY-D-MANNO-OCTULOSONIC-ACID TRANSFERASE/TRNA GUANINE-N 7 - -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417:SF16">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 11" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="129"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="173"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="271"/>
            <end position="273"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCF52056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WWC69714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="297" mass="33774" checksum="7AED65339F09D1AF" modified="2016-11-02" version="1">MSKRTHDQVEEMEAGPSTVTSTSTSSLTPATNGSNDVNIGLLQLPQKRFYRQRAHANVFVDHELDYPKSPSEMDWSYHYPKYFTHPDQTEPSSIQNEKKVEWADVGCGFGGLLMALAPMFPDTLMLGMEIRMSVTKYVTDRIAATRQYQSMLPSNSTERENGEYQNVSVIRANAMKHIGNFFEKGQLSKIFFLFPDPHFKNRKQKARIITPGLLAEYAYVLKPGGILYTVTDVKDLHEWMALHLNNHPLFIPIPNEELTGDAILEAARTSTEEGKKVERNKGDKWVACFRRAENPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I998</accession>
    <name>A0A1B9I998_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit delta, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">F-ATPase delta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I206_01328</name>
        <name evidence="17" type="ORF">I206_103671</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013263.1">
        <property type="nucleotide sequence ID" value="XM_019153102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I998"/>
    <dbReference type="STRING" id="1296096.A0A1B9I998"/>
    <dbReference type="GeneID" id="30169697"/>
    <dbReference type="KEGG" id="kpin:30169697"/>
    <dbReference type="OrthoDB" id="270171at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.15.10:FF:000003">
        <property type="entry name" value="ATP synthase subunit delta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="entry name" value="F0F1 ATP synthase delta/epsilon subunit, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048938">
        <property type="entry name" value="ATPD_C_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="ATP SYNTHASE DELTA/EPSILON CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822:SF7">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT DELTA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21334">
        <property type="entry name" value="ATPD_C_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="Epsilon subunit of F1F0-ATP synthase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP synthase F1 complex delta/epsilon subunit N-terminal" evidence="14">
        <location>
            <begin position="37"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="F1F0-ATP synthase subunit delta C-terminal" evidence="15">
        <location>
            <begin position="125"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCF52044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="WWC69728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="169" mass="17711" checksum="EEFE2739F73596B8" modified="2016-11-02" version="1">MFASRLSSSLRALPRQASAVRMARRGYAEAAGSDGKLQLSLVLPHQSLYSSAGVIQVNLPAATGDMGVLANHVASVEALRAGVVEVIEENGQAGKKWFVSSGFATVHGNNTLTINAVEAYPLDTFSAENIRSGLADANRVLSSSAPESEKAEARIEVEVFEGLQAALAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I9T1</accession>
    <name>A0A1B9I9T1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA-directed RNA polymerase I subunit RPA49</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_01436</name>
        <name evidence="8" type="ORF">I206_103560</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC69617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013370.1">
        <property type="nucleotide sequence ID" value="XM_019153209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I9T1"/>
    <dbReference type="STRING" id="1296096.A0A1B9I9T1"/>
    <dbReference type="GeneID" id="30169805"/>
    <dbReference type="KEGG" id="kpin:30169805"/>
    <dbReference type="OrthoDB" id="532500at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009668">
        <property type="entry name" value="RNA_pol-assoc_fac_A49-like"/>
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    <dbReference type="PANTHER" id="PTHR14440">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06870">
        <property type="entry name" value="RNA_pol_I_A49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCF52151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC69617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="431" mass="48195" checksum="3D492EB94E0A0BD4" modified="2016-11-02" version="1">MASALQSNKKSHKRKSEAGSGQSDLQVIVEDPSTSAGPAFVNFPSVRPSKNTPFTIYTRDVGSSSDITKQHTLIAGETEDVEFFSTNRDHNLNTEGSDCQYLPALYDPSTGSVHIHPSTPLYLLTHGVKRLRSSVNAQLLDKQAHWKTQRNDLGETFGTRKAKTQIRAEERNKVDVGAMQGVKGHLMGSIPELAVNDGPVLANESIPTPNLTTSDPTEVYPRDSLISSQEWSSIDVKALQQAEDDDSRQKALPWRRKLGWFHSRIRYFNSLEDKTVRRTQLRYIFYLSTLCLLRENAAVLSKLSAAELPNKFPNVPSQLLDGIIKRFAEPKEKRYVITEKSHVKLLAWICVLYLHVGGFSVDTSRVASDLKMDKTKIENMFKNVGCTVNMDTPAERERKGISMAEASASRKAVLKAPVVFPRQKTRGPTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IAD5</accession>
    <name>A0A1B9IAD5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosomal protein L10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_01807</name>
        <name evidence="3" type="ORF">I206_103189</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013735.1">
        <property type="nucleotide sequence ID" value="XM_019153574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IAD5"/>
    <dbReference type="STRING" id="1296096.A0A1B9IAD5"/>
    <dbReference type="GeneID" id="30170176"/>
    <dbReference type="KEGG" id="kpin:30170176"/>
    <dbReference type="OrthoDB" id="360689at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047865">
        <property type="entry name" value="Ribosomal_uL10_bac_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF52516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC69252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="31874" checksum="E329DA5633D514A3" modified="2016-11-02" version="1">MPPRPSSAIRALSANRFASTSTIPSSSIPIISSATASTSSIPLSITSSSSSELTNVNRIYTTRKTFLWNYYTHLIERSNLIIIFEHSNLTSSEWSKIRNSIKSIPLPNKPFDFNSKNPELIEKANLNVIRTGVLNSLLFKKQSPLILSKENENIIKGQRALLTCKNLSPIYLKQILNKINISLKSLKRDLNSNSNENEKKQPNLKIISILLEGKKILNNEIELNEFLKNTPELDLLRGQLIGILQSPTRQLNGILNQAAGGQLVRTLKGLENDLKGENSKGDEKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IAL8</accession>
    <name>A0A1B9IAL8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_01951</name>
        <name evidence="6" type="ORF">I206_103045</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013877.1">
        <property type="nucleotide sequence ID" value="XM_019153716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IAL8"/>
    <dbReference type="STRING" id="1296096.A0A1B9IAL8"/>
    <dbReference type="GeneID" id="30170320"/>
    <dbReference type="KEGG" id="kpin:30170320"/>
    <dbReference type="OrthoDB" id="17395at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050032">
        <property type="term" value="F:L-rhamnonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03327">
        <property type="entry name" value="MR_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000005">
        <property type="entry name" value="Putative L-rhamnonate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023444">
        <property type="entry name" value="L-Rhamnon_dehydrat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046945">
        <property type="entry name" value="RHMD-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011968">
        <property type="entry name" value="PRK15440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794">
        <property type="entry name" value="ENOLASE SUPERFAMILY, MANDELATE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794:SF58">
        <property type="entry name" value="MITOCHONDRIAL ENOLASE SUPERFAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00179">
        <property type="entry name" value="mandelate_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00006">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme C-terminal" evidence="4">
        <location>
            <begin position="168"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF52658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC69109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="421" mass="46608" checksum="43D1CC49E17376B7" modified="2016-11-02" version="1">MPKEWPTIAKLETFIPSAQGSGGDYHRQKGGHWIIQGDISCPMHKYPDWRESRAKWGIGVLGSLFVKITATDGTVGYATGFGGPPACWLIEEHFSRFVVGADPRDTNAIWDQMFRASIFYGRKGLPMAAISAVDLAIWDLLGKIRGEPIYKMIGGRTKKEIPLYLTGPQSASAKKLGFWGSKVALPHGPPDGVEGIRKNVAYLKAKKEEVGPDYPLMVDCWMSLDVPYTLQLVKAVEDAGVKIHWWEEVLHPDDFDGHRTLKKAFPHILFTTGEHEYSKYGFRKLIEDRSIDILQPDVMWLGGLTELIKVASMAAAYDIPVVPHGSGPYSFHAIMSFPNSDFCEYIANSPDGHTVLPSFGDLFTNEVLPLNGKVNLTDEPGFGLTLNPNAQLVPYSDFFKPVKGIGYASEKPEEVAQEASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IAV0</accession>
    <name>A0A1B9IAV0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pali-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_00058</name>
        <name evidence="8" type="ORF">I206_101264</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF52762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013981.1">
        <property type="nucleotide sequence ID" value="XM_019151843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IAV0"/>
    <dbReference type="STRING" id="1296096.A0A1B9IAV0"/>
    <dbReference type="GeneID" id="30168427"/>
    <dbReference type="KEGG" id="kpin:30168427"/>
    <dbReference type="OrthoDB" id="2354757at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051380">
        <property type="entry name" value="pH-response_reg_palI/RIM9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013:SF3">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628467" description="Pali-domain-containing protein" evidence="6">
        <location>
            <begin position="26"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCF52762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC67356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="27429" checksum="9895047F4F243DDA" modified="2016-11-02" version="1">MAAGIKCGSFFLFAAFALLLVSSLSAPVFRQISFLDIQTGNQKLAFGVFGYCTNVNGNGNHGCSSRQLGYDIASISGEVSSFTYVNDNLEHITKALILHPIATGLTFISFIIALFSDRLGFIFAALIAFLAFLISLTAMIIDFVMFGIIKHEINNNTTTAEAKFENAIWLTLAAVIILFFSTFVVCFETFTNRRNQRSTTSTSTTTRRDKESGYVNGGYIGNQGSMINQNGGYVAPPPPKKHFWQRNRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IB51</accession>
    <name>A0A1B9IB51_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptide-methionine (R)-S-oxide reductase</fullName>
            <ecNumber evidence="5">1.8.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_01910</name>
        <name evidence="8" type="ORF">I206_103086</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(R)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="5"/>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013836.1">
        <property type="nucleotide sequence ID" value="XM_019153675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IB51"/>
    <dbReference type="STRING" id="1296096.A0A1B9IB51"/>
    <dbReference type="GeneID" id="30170279"/>
    <dbReference type="KEGG" id="kpin:30170279"/>
    <dbReference type="OrthoDB" id="44061at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.20">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00357">
        <property type="entry name" value="peptide-methionine (R)-S-oxide reductase MsrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46081">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46081:SF8">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MsrB" evidence="6">
        <location>
            <begin position="62"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCF52617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC69150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="185" mass="20487" checksum="C1C29326D8A1959A" modified="2016-11-02" version="1">MPFIPSSLVRSTIYTARNQIPTTIKPNQAIKLSGIGLPFAGFFSTSSTNKMPSDNFPVKKSEDEWHAVLSPEQFRVIREKGTERPGSHAYDKKNDAGVYHCAGCDAPLYTSKTKFNSGCGWPAFYDTIPGAVIRHEDRSMFMTRTEIVCANCGGHLGHVFKGEGFPNPIDERHCVNGISLNFKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IBR5</accession>
    <name>A0A1B9IBR5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Condensin complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I206_00393</name>
        <name evidence="15" type="ORF">I206_100933</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CND1 (condensin subunit 1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014311.1">
        <property type="nucleotide sequence ID" value="XM_019152173.1"/>
    </dbReference>
    <dbReference type="STRING" id="1296096.A0A1B9IBR5"/>
    <dbReference type="GeneID" id="30168762"/>
    <dbReference type="KEGG" id="kpin:30168762"/>
    <dbReference type="OrthoDB" id="436262at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000779">
        <property type="term" value="C:condensed chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010032">
        <property type="term" value="P:meiotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026971">
        <property type="entry name" value="CND1/NCAPD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032682">
        <property type="entry name" value="Cnd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007673">
        <property type="entry name" value="Condensin_cplx_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024324">
        <property type="entry name" value="Condensin_cplx_su1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222">
        <property type="entry name" value="CONDENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222:SF2">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12717">
        <property type="entry name" value="Cnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12922">
        <property type="entry name" value="Cnd1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017127">
        <property type="entry name" value="Condensin_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="6 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensin complex subunit 1 N-terminal" evidence="13">
        <location>
            <begin position="81"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Condensin complex subunit 1 C-terminal" evidence="12">
        <location>
            <begin position="1068"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="490"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1313"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="494"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="528"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="539"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1332"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1353"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1378"/>
            <end position="1390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCF53092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WWC67026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1390" mass="156024" checksum="96DAED1D3A82D2D7" modified="2016-11-02" version="1">MSEEFNLQESLLSLSDLSLYHIPAEIDVPSLRTSSIDESLSTAIESIVHDPDSIVHQPASTFDVFQSILKYSDSPNITGPILTKLLDVILSSLTNHANAVVTLVGSQGFSAEDMDAPMIHKQPLEMWSFLLQWFITSAERGAGKSSDGSSMTTTTGKGKKKITNKQNSSSTSTNFIWIDQLPFVLSTIHKILKIPTSRIWRTTSEKENFISCFVKPSYQLAENELYLKNQEIKFGIYKIICLSVKFHNHAFGAQTSIIQNLTYFEHFSEPMAELLSILEKEFDHSQLSEEVLRDVSTKTFAHNDVKGPRSFSKFLIKFAELSPRIVSKQMPLLLGHLDSDAHPMRMAIVEIIGILIRDLSLSDEGDEEQKSKQIKKYFELLMERFLDLNSWVRCKVLTTLIKLCDLPAKFPKQRHQIVELTIRTLEDKTSSARRYAIQLLCKLLETHPFGALHGGTLNLAEWQERYDKVSTELAKVDAIELEKAKRDVGLLDGEAGEQEEAEEEGEENAGEVDEDMDNAEEVEGTPKPKSKRKERKPRQSQLDITGIQAEQSTLDPELIQRLRLTKKYYSDALRFINQLEGAVTTLCQLLVSTTKTEVLEAMRFFRIAFEYDLQSSEIGIKTMLHLIWTKDNNAAPVATTSATVTNEDGNPATGMESGGKGIRANLIDCYRSLYFDVVPDLAPKQQVNRIAKNMIERTYGATLAELTSLEELMRTMMAEGGVHHDVVNKLWQVYSTDQEIPKPQRQGAIIILGMLALAKREVVTERVEALLKIGLGPLGMHDLVLARYTCIALQRLGGSAKKVKGSLSDKTMRLPMDNPIFVKLQEIIEHSPRSPQWFSMAEQAINTIYLLGEQPDALCSVIIKDLTVKVFEKPSNSTDETNPPPAGDANAEADETIREDHLAPEAESPTSNGNGEVSEKKDQVGSFKLAQLVFIVGHVAIKHIVYLELVEREFKRRKDETAKQKAAAKTADKDSNDLDAVAGNAEDDIGELISGIRERELLFGDKSLLAVYGPMIAGICASPKRYKNPSLRQAATLSLTKLMCVSAQFCESHLLLLFKILETSRDPVVRSNIVIALGDIAVCWGSMIDDNSERLYQGLSDPDPIVKKNTLMVLTHLILNGMIKVKGQLGEMAKCLEDKDERISDLAKLFFTELSTKDNALYNNLQDVISHLSIGQHKVDEETFERTMKFIFTFIEKEKQAESLVEKLCQRFRLATEERQWRDISFCISLLPFKSERSMKKLIEGLPFYQDKLHEETVFRRFTEILAKARANKAANKPETELKEFEAILTEHQAKGLEDQALEADVLKKTKAAKRRAAKRPQAGRGKKLATQEDEEEEEDEDSRPAPAPTRNTRGKAPAKKPPPKPAKRGGRRKIVESDEDDEPDLSGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IC48</accession>
    <name>A0A1B9IC48_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gfo/Idh/MocA-like oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_00305</name>
        <name evidence="6" type="ORF">I206_101021</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014223.1">
        <property type="nucleotide sequence ID" value="XM_019152085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IC48"/>
    <dbReference type="STRING" id="1296096.A0A1B9IC48"/>
    <dbReference type="GeneID" id="30168674"/>
    <dbReference type="KEGG" id="kpin:30168674"/>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF5">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="6"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="4">
        <location>
            <begin position="149"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="243"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF53004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC67114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="400" mass="43913" checksum="5475DB2DF55099CB" modified="2016-11-02" version="1">MSDANIKIALLGTGIYAESDYVPSLLQDSQKHIEVKIIWSLDQTAAQRFADQFKAAGRAELQVAIGEAGIEQILNDTEIDAVVVVLPFAHQPPLIKRFWAAGKHVLSEKPIERDIEAGLAFVKEFEDNWKPKNLVWRVAEDYDHEPIHKRAAELLADPAMGPVLFWDLQNQNYCPDGDKWQATSWRNVPDYQGGFCLDGGVHSIAMLRVVLPDPPASVIASASLHRKHTPPHDTIVALVLPDSGATKEPSGTSSKLDIARQHSAKLPEPGRSTPAGTITFTWALPNIEPRAPQNLQVLNITCLNGKLTLVNNEGTRTLEVVPAIGSQVKAVKETSRKKGVEVELAYFARAVQATKAGRPIDPKEDFGKPMNTVWDVAVIQAMLQSNGEKVDIKQLIAQYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IC88</accession>
    <name>A0A1B9IC88_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sulfide:quinone oxidoreductase, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_00437</name>
        <name evidence="13" type="ORF">I206_100889</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SQRD family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014355.1">
        <property type="nucleotide sequence ID" value="XM_019152217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IC88"/>
    <dbReference type="STRING" id="1296096.A0A1B9IC88"/>
    <dbReference type="GeneID" id="30168806"/>
    <dbReference type="KEGG" id="kpin:30168806"/>
    <dbReference type="OrthoDB" id="5376590at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070224">
        <property type="term" value="F:sulfide:quinone oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070221">
        <property type="term" value="P:sulfide oxidation, using sulfide:quinone oxidoreductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000034">
        <property type="entry name" value="sulfide:quinone oxidoreductase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015904">
        <property type="entry name" value="Sulphide_quinone_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632:SF2">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0874">Quinone</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="11">
        <location>
            <begin position="21"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCF53136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC66982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="441" mass="48019" checksum="87C0BF17B1C554D4" modified="2016-11-02" version="1">MSVLPRNFARLASTSAAGKHKVVVIGGGAGGLAAANQIYNAFKSQGKTLGDGDVAIIDANKNHDYQPGWTIVGSGLADKQSYRKPLDSLISPHFAHIPQNASAFEPGANQVVLADGSKVSYDYLVVAAGIQINWDNIKGLRNAIADPLKSKVSTIYSYETADKTWDLVRNHKGEGEAIFTQPLGVIKCAGAPQKVAYMSDSFWKSQAETSNNHSTFITGMPSMFAVPDYAKALNAIREKKGIDALFNTNLVEIKPDEKVAVFEVVAGEDKGKKIEKEYGILHAVPQMGPLDWIKKSPLADSVGWVDVDQGTLQHKKYDNVFSLGDSSSLPTSKTAAAITGQTPVLTHNLVTLMETGKVGNAIYDGYTSCPLFTGRGELLLAEFKYGAQRKESFGRFTDQTVPNRLFYHLTKDIMPRAYFSRMLKGEWYGPRTIFPPSFLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9ICL2</accession>
    <name>A0A1B9ICL2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">2,2-dialkylglycine decarboxylase (Pyruvate)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_00654</name>
        <name evidence="6" type="ORF">I206_100671</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014571.1">
        <property type="nucleotide sequence ID" value="XM_019152433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9ICL2"/>
    <dbReference type="STRING" id="1296096.A0A1B9ICL2"/>
    <dbReference type="GeneID" id="30169023"/>
    <dbReference type="KEGG" id="kpin:30169023"/>
    <dbReference type="OrthoDB" id="10261433at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000004">
        <property type="entry name" value="Acetylornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45688">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45688:SF13">
        <property type="entry name" value="ALANINE--GLYOXYLATE AMINOTRANSFERASE 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF53352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC66766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="442" mass="47949" checksum="A17653EA1642F631" modified="2016-11-02" version="1">MPAPTFDSNQFWSDADNHLIRYSGGGDFVRRVIVKAQGSLMIDSEGNEIIDWTSGQMSSMLGHGNQEIVQVVNDSMSTLDHLFSGFISKPVVEASKFLSSLLPSKLTKVQFLNTGAESNECALRMAKLYTGKHEIVSFSSSWHGMTQAAAAATYSAGRKGYGPNSPGQFVLPTPNPHRSRFRNADGSYDWEAELNFGFELIDCQSTGNLAAAIVEPILSSGGVIELPHGYMQALKAHCEKRGMLLIIDEAQTGVGRTGDMFAFEHEGVVPDILTLSKTLGCGLPVAATITSAEIEQNVFEKGFLFYTTHVSDPLCAAVALKAMEIVTRDQLHLRARKLGKIVKDGLLELQKKYKCIGEVRGRGLLLGVEIISGPDSTESAQVLGAAISDRCMDLGLSMNIVRLAHMGGVFRIAPPLTISEELVEKALDLMDEAFRTTKGTTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9ICS4</accession>
    <name>A0A1B9ICS4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_00748</name>
        <name evidence="2" type="ORF">I206_100577</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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    </reference>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
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                <person name="Hansen M."/>
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                <person name="Imamovic A."/>
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                <person name="Murphy C."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
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                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
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    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="7">CBS 10737</strain>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
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                <person name="Young S.K."/>
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                <person name="Nusbaum C."/>
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    <reference evidence="12" key="2">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
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                <person name="Berlin A.M."/>
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                <person name="Dewar J."/>
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                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
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                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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                <person name="Saif S."/>
                <person name="Birren B."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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                <person name="Litvintseva A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
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                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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                <person name="David-Palma M."/>
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                <person name="Bowers K."/>
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                <person name="Mohammad A.W."/>
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                <person name="Yurkov A.M."/>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
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                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
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                <person name="Nusbaum C."/>
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        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014926.1">
        <property type="nucleotide sequence ID" value="XM_019152788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IDY1"/>
    <dbReference type="STRING" id="1296096.A0A1B9IDY1"/>
    <dbReference type="GeneID" id="30169382"/>
    <dbReference type="KEGG" id="kpin:30169382"/>
    <dbReference type="OrthoDB" id="3643at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049517">
        <property type="entry name" value="ACX-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF2">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19278">
        <property type="entry name" value="Hydant_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="2">
        <location>
            <begin position="10"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="1">
        <location>
            <begin position="277"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Acetophenone carboxylase-like C-terminal" evidence="3">
        <location>
            <begin position="581"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF53707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC66410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="769" mass="84527" checksum="4488F098C1A829AA" modified="2016-11-02" version="1">MSQVQDHSIRISIDRGGTFTDVHVSTLSKVGSGSIYQDESNREEFILKLLSQDPGNYKDAPTEGVRRALERVTGEKYQRGKPLPVNKLEYVRLSTTVATNALLERKGQKHALIITKGFKDLLEIGNQARPRIFDLNIKRAKPLYTKAVEVDERVTLVGYSSDPQAEKNALIFNEDGTIKKAYSGLGSEEQENLIPGKIVKGLSGEAIKVIREPDLEIVKKDLQSLYDEGYRSIAVCLAHSYTFPDHELAIGKIAEQVGFPHISLSFQLLPMIKMTNRGQSTTCDAYLTPVLQDYLKGFYAGFEGGEQGDLHVEFMGSDGGLVDLNNFSGLKSILSGPAGGVVGCALTSWDEEERAPVIGLDVGGTSTDVSRYAGRYESVWETTTAGISMFTPQLDINTVAAGGGSCLTYKNGLLRAGPESAGAHPGPACYRKGGPLALTDGNLFLGRLVPKYFPKCFGPNEDQDLDPEASKTKFEELAEAIRAETGTDKTIDEIVYGFVKVANETMARPIRTLTEARGFKTTDHILASFGGAGGQHACEIAELLGIHRVLIHKYSSILSAYGLALADRVYEQQEPASDTFNSSTQSSLFSRLDNLSQKVKKVLKESGFDDNKIQVERLLNMRFDGSDTALMVLETANGKGDFEDEFKRAYKEEFGFLLNKNIVVDDIKVRGIGKTFDSLGPSAFAELKTLKLSTVDSRRADFHQEAYVWYGKDGKRQNVPVYELESLQRGDQVDGPALVIDETQTIFVNVHWSAIATSNHLLIQRKVHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IE01</accession>
    <name>A0A1B9IE01_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_01033</name>
        <name evidence="10" type="ORF">I206_100292</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014946.1">
        <property type="nucleotide sequence ID" value="XM_019152808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IE01"/>
    <dbReference type="STRING" id="1296096.A0A1B9IE01"/>
    <dbReference type="GeneID" id="30169402"/>
    <dbReference type="KEGG" id="kpin:30169402"/>
    <dbReference type="OrthoDB" id="547796at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF72">
        <property type="entry name" value="NEUDESIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="8">
        <location>
            <begin position="58"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCF53727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC66390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="178" mass="20048" checksum="6573530675EF0132" modified="2016-11-02" version="1">MSFANPLNVLLIPPIIYLVFRLIVPHPLKQTPAASTYSEEVYNWIPSKHPDIICQKKYTAKELLEYDGTGKKKGGQRILLAILRVGLDGKWGERTVFDVTAGKTFYGPDGVYGNFAGRDASRGMAKQSFELEMLTPIDDPLDTLSDLTRAEIDNMRGWHEHFERKYIVCGELVEDGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IEB5</accession>
    <name>A0A1B9IEB5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_01078</name>
        <name evidence="3" type="ORF">I206_100247</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
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                <person name="Dewar J."/>
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                <person name="Hansen M."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
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                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <authorList>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
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            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IEH1</accession>
    <name>A0A1B9IEH1_9TREE</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
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    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
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    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
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    <comment type="similarity">
        <text evidence="1">Belongs to the TfdA dioxygenase family.</text>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="AtsK-like"/>
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        <property type="entry name" value="TauD-like_sf"/>
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        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="80"/>
            <end position="346"/>
        </location>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCF53831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC66286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="385" mass="43146" checksum="D7FFC715C3E004C3" modified="2016-11-02" version="1">MPIAVANNQDSRGRPFHLAKSTKERLENAGLDLSNGYPYFPDKPKDLDAALRKQEWTFKEPGLRADKEKKALLSAAKEVIHLSPHLGTEIVGLQLSELTDQQKDELGLLIAERTVVFFRDQTLTPQDQLELGKWYGVPEVHPTAARVHKDLPGVTIITDEIAKTNGLDPDYKSPYGTQKWHTDLTHEPQPPGVTHLHLDHIPGVGGDTLWASGYAAYDKLSPAFQKLIEPLEGLYRSAHSYTDPVTGKQAPIINAHPLVRVNPATGWKALFVNSRFTVGIKGFEYSEAQAILNKLFQVYEQNTDIQIRFKWTSRTSALWDNRISIHSAVYDYLDEDTNEPRHGTRVSSLAEKPISVASAPNATSRREALGLNTGKVYELQRDEHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IEL5</accession>
    <name>A0A1B9IEL5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_01181</name>
        <name evidence="2" type="ORF">I206_100146</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019015093.1">
        <property type="nucleotide sequence ID" value="XM_019152955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IEL5"/>
    <dbReference type="STRING" id="1296096.A0A1B9IEL5"/>
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    <dbReference type="KEGG" id="kpin:30169550"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="NUCLEAR MRNA EXPORT PROTEIN THP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="OCF53874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC66245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="471" mass="53682" checksum="7C0295A496D89DAC" modified="2016-11-02" version="1">MSSLVSTFITHISQCFVTASAENLLTSIPLTAEHPFFGPLRQALSTVSESSISSSSVTQQLGFIGNDIKDNLATFISAILKNVQGIPSSTSVDEAYSSFSSLSSVYNEANKLYAMTNNDGQQIHAFMNPLMVILAKSLVKVSNHAALLSTLPLRHPKSSRSIRDSTRQVIERSLQISNTTTSESDWNANSNQQYLVGDIIWDLSIILFRIYAERKLHSQSAELSRTLESLSPHENKRLTARGQNITSTTICQSYYWRGRIRLVLLDFRQAKYWLDKAWGMVPKDQQGWKQRRSIIIRLIAVKILLGRIPNENTLSEYNLPEFLPLIHAYKTGNIPLWRKTLDNNRDWFRKRSIWLILYERGEILLWRNLFRQTLKFYHQFDSSLPKNKCPTWIFISAVHKTFLNTGEIEDGSIELEDIICIISSLIDHGLIRGFLSYSHRQLIMKPTQNGLGCFPKISDVEPRKIQLAGQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IER2</accession>
    <name>A0A1B9IER2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chaperone regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_01238</name>
        <name evidence="5" type="ORF">I206_100090</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019153012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IER2"/>
    <dbReference type="STRING" id="1296096.A0A1B9IER2"/>
    <dbReference type="GeneID" id="30169607"/>
    <dbReference type="KEGG" id="kpin:30169607"/>
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    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006413">
        <property type="term" value="P:translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Heat shock protein 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000049">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.14, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
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        <property type="entry name" value="DnaJ_domain"/>
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        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
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        <property type="entry name" value="DnaJ_subfamily_B"/>
    </dbReference>
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        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
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        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078:SF553">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="JDOMAIN"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="6"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF53931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC66189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="364" mass="38393" checksum="04A63820509466AD" modified="2016-11-02" version="1">MVNNTEYYKILGVGKDASEAEIKKAYRKQSLLNHPDKNPGDKRAAAEEKFKKLGEAYEVLSDPNKKEVYDQLGEEGLKGGAGPGGPGGGGGFGGFPGGGGGGGFSFHAQDPNDIFNAFFSSSGGGGGGMEDIFGGMGGGRGGPRMRSSRMGGGMPGGFGGGMGGMGGGDPHGQSSTKPPPPGEIIKPLALTLEELYKGGTKRLKITRHLQNGSQEEKILEVAYKAGWKKGTKIKFAGAGNEDEFGQSQTVTFVVEEKSHNRFERIDDDLIIKLNITLSQALLGPEGGGAITKEVEQLDGRRISVSTTEGQIVQPGQETRIQGEGMPVSKAGSAKKKGDLIIRWNVVFPTRITPEQKKELRKVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8KYI3</accession>
    <name>A0AAJ8KYI3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HORMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_100731</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058365.1">
        <property type="nucleotide sequence ID" value="XM_070202264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8KYI3"/>
    <dbReference type="GeneID" id="30168965"/>
    <dbReference type="KEGG" id="kpin:30168965"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051598">
        <property type="term" value="P:meiotic recombination checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007130">
        <property type="term" value="P:synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051294">
        <property type="entry name" value="HORMA_MeioticProgression"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48225">
        <property type="entry name" value="HORMA DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48225:SF7">
        <property type="entry name" value="MEIOSIS-SPECIFIC PROTEIN HOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20826">
        <property type="entry name" value="PHD_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HORMA" evidence="10">
        <location>
            <begin position="45"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="387"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="488"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="559"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="801"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="579"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="594"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="604"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="801"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="841"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC66824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="897" mass="100178" checksum="A277A21A01F4D154" modified="2024-07-24" version="1">MGPQRMAFRPPAPVNKPASQKSASQMPAERLETQQKLDLAITTKDDSLKMMKVALQAHIGIICYLRALLPNGDFETHYISNSHPPPNKSVEDLFYLTRKEAEECYQKSIENDKDETQDISGQNSKFFQWRKVRQDGSPQGKALANLIGVGATDAMNKGYLQSLVLAIFLDPNDPNNVVETYTFNFFYNDEGQPFMDLEHSAEVSDKFDHKATGITLRRNSVLGTPMSNLDVRRLIKRQAVDIIKHTETLSDLPKKRYMTVKLFYNDSAPSNYSPPGFEDAIGEEMVIGTHNVNDPPLKIPMREFQTGHHGLTATALTVVDHLPKTLYDDESIDGPEKYARLYGQKAEYEEDARQRNVIWAADLPIHDRAVYDPTAPDVYTATINPHKAVPEDASGGLKQPIGRRGDDGTIVDITPSQVGSGKQRAMRRNACKAAGSRYIPEESIQQSQTLLSRTPLRGRTASLPRAHHGQSLAEDLFIPISQSYSGNDSQAYLGKVPEEEEEDESNTQPLSSQKLARDFHEKIALQKRKSDIEIEPLPRPRKRNIDKIVEASMLQNGYELKARSNGKARSVPKTDKPAKARKTRTPRKPRSKIAKVDTEDNKASKKTKAAPAKKRDKRQQSHSQDIIECFCGLNEEIDAMIQCDGCDMWYHAICLGILDRAFAVNRQVLCIACEMKQDKHTKWNRKQIEVAVKEMGTLALTRKVLQEVKRLGSLGSDDLNALSKSLGCSVSELKRILEGLTGVYADIYPAQQASDNNSEVTEWKWLKTPPAVKAFTRFFQYGGGVEKDIFVIRKWHSSESQTQTQSQSLSQPQSSPEPTSSQPDYVADSQGEDAQGELRSDSSSGQNGFSVFNSTQNSISTQGYTPYCVPTIKSSKAINIIDCTDVWTGNNDIEEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8KYN5</accession>
    <name>A0AAJ8KYN5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_100806</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058380.1">
        <property type="nucleotide sequence ID" value="XM_070202279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8KYN5"/>
    <dbReference type="GeneID" id="30168890"/>
    <dbReference type="KEGG" id="kpin:30168890"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="NUDIX_CoAse_Nudt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF44">
        <property type="entry name" value="NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="498"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="76"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC66899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="533" mass="58726" checksum="BFEB2D228ECF9559" modified="2024-07-24" version="1">MTDFHPPPSADLLALLQDMRLSVPRVIQSPPTQPRRASVALIIRLKPAPELVFEGHEQEGYTGEVIKQSDFGLGYTLDDFFRLPWVNHPNTTPEILFIRRAPHQSSSSAPSSSSSGSSSSANTSSQGRWSSHIAFPGGRHEPDDQSAYFTALRETWEEVGIDLAEKEFLHVGRLDEREVTTSLGKRLLMILSPFVFLQTSPFSPVPELQATEVSSVHWIPLSLLAPPFDTAQWSQVEIDISSRLSPRNTFVRWCLRNLIGKMQFGCVLLPDEPDTVAEGFDPSLAFDDSAEGSGSWFNDGKRHLRLWGLTLGMTLDLIAHYPSSTPAHLVLPPTSSRSSSPTASEFNHDQIRDSADFISDPKTPVTVTSSFEDQWEAARLALEEAKKNRTPATGSDKIEGASGAGLTAKGDLGIKVDVEGRRKGKNKRRRGVGPGMTAVFPKFSYPDVNFWIWVFGRRYRQVIQGWENSVRGPDRAADRRVNWSGQALATFYSAVRQALVVAIIMRALLSGIGIAGLTWIFVKGIGGFGGNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8KZ71</accession>
    <name>A0AAJ8KZ71_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sterol 3-beta-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.173</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Autophagy-related protein 26</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">I206_100378</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a sterol + UDP-alpha-D-glucose = a sterol 3-beta-D-glucoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22724"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15889"/>
            <dbReference type="ChEBI" id="CHEBI:37424"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.173"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:22725"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ergosterol + UDP-alpha-D-glucose = ergosteryl 3-beta-D-glucoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61836"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16933"/>
            <dbReference type="ChEBI" id="CHEBI:52973"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:61837"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.173" evidence="4"/>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014859.2">
        <property type="nucleotide sequence ID" value="XM_019152721.2"/>
    </dbReference>
    <dbReference type="GeneID" id="30169315"/>
    <dbReference type="KEGG" id="kpin:30169315"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016906">
        <property type="term" value="F:sterol 3-beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13215">
        <property type="entry name" value="PH-GRAM1_AGT26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13216">
        <property type="entry name" value="PH-GRAM2_AGT26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000303">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000391">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000029">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000009">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048066">
        <property type="entry name" value="ATG26_PH_GRAM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048065">
        <property type="entry name" value="ATG26_PH_GRAM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF25">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="12" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="15" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PH" evidence="21">
        <location>
            <begin position="505"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="212"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="727"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1561"/>
            <end position="1627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1650"/>
            <end position="1694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="214"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="275"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="327"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="729"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="767"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="818"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="838"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="893"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="1585"/>
            <end position="1596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="1603"/>
            <end position="1615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="WWC66476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1694" mass="187970" checksum="C98299A0E92C7128" modified="2024-07-24" version="1">MTSPSPPPDRQTNNANLSAPPFPESAVSPDQRDPAPKHPNAEHLINTAAKLVFPSQPRPGEDKDGKDDKIPDTSKGLQEGARTKEEKEEKAIIGGTPLDELPYTPAFDIPSFTSRKSEIKQVDLDVEPITEEHRLEEEERQSGDTLNPIPSAQSKGDATSLSNSTTKLPNDRSRDIGKMSQSDTRPGFGAGKDIGSVRMGASALVSALNALPWDDGESSSDEDEDDDSYPPSGSRKQSASVLEEKSKRPHFNRLGSSLHTIRPMIQPHADEHSNTPQRSQTAQAAQSTNSLRFPFRDNTIARRARRPNETELSYQYAEDQARRLSIQDPSNDVSSGDSSPQIDESRRLSDPASETSSIGAPAREMLNEQISHEEAIGEAEERDEIVRAAESSPATSSAPLDLDLAPVVGEQEQQDMNADAALRQPESLQEEAVEHDIKPNENEKRRLRKEKLAERLMEVFGLDEKEEVLEEMRCWLLRSVMLKGYMYLTKRHICFFANMPDKDNLIVKTGPLSKKNSRTKLNTKFWVILKNDVLSWYESTADPYFPKGNISLQYCTSCDATDELKFKVRTAEKNYTFTTDTEASRDEWIKAIQKVMFKLQHEGESVKLIIPLEAVMEAERSPTLEFAETIEIKCVDVDDNMSVESYFFASFQNNDRAYSRIQQVLDDRPSWELPRISSAVTIQQPAEALEDSVNTIRRPVQPSESTNESGFGIKRIGSVLKPLLSRSSDQVHETDSHKSGLTIPFLSNKNHKTSQDSLETVRHEPILEDEVESPDEAYDDGYPPRQSGQPPAGMKHDDSKNWGPSWIRKPASKILGTSPGSTSTLGKSPESTYGQGISRTSTNTTRTGGHKKHSVTEIVEPALPKEHDSSDDESSQRPGAFSGGRAQRPSFASDASGSSQMGHSRSDFSMMEASETGQREDDETASKFRDVFALSEKEELIDHFPGYLFRVLPVSGRFFISTNYFCFRSSQLLYKTKMIIPIKDLYGLKAQKAFRFGHSGLIVVIKGHEELFLEFSSSKRRKACVRLLEERMEAVRVSGEQGEPDQADIETRIMEDLDESQPLESRLSNNNVPPVSPSPLFGSTTSTFLEFKPEPMRVTCLTIGSRGDVQPYIALCKGLQAEGHTTRIATHGEYKDWVEGHGIEFASVGGDPAELMQMCVDNGMFTVSFLKEGLQKFRGWLDDLLTSSWEACQGSDLLIESPSAMGGVHIAEALRIPYYRAFTMPWTRTRAYPHAFAVPEHKRGGSYNYMTYTMFDQVFWRAISGQVNRWRRHVLDIESTTFEKLEQHKIPFLYNFSPSIVPPPLDWTEWIHVTGYWFLENADESQSNEKKWTPPEGLVDFIEGAHKDGKKVVYIGFGSIVVSDPEEMTRCVVDAVVESGVCAILSKGWSDRGSKSKGDDTGDSKGADGVKYPPEIFSIDSIDHSWLFPRIDAACHHGGAGTSGASFRAGIPTIIKPFFGDQAFWAERAESLNVGSAIRKLTSEALAEALIKATTDAKQIAKAKIVGEMIRKENGVSKAIEAIYRDLEYAKSIIKPLPEAEDKPLDKVTSLLHTDSIVPFRSRSRTKSSPSKSDLEPDTQSSSDDVERDRDVHASDDGWSVVSGNDNNGRSRNSSVTQVAESKPSGVGVIGSIVKGNELISGLGKALPISNPFSLKKKKDKKVHEEDDDEDEPALDSAFVEGTAGAKDSDISTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8KZE3</accession>
    <name>A0AAJ8KZE3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Csf1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_101180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058443.1">
        <property type="nucleotide sequence ID" value="XM_070202342.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30168514"/>
    <dbReference type="KEGG" id="kpin:30168514"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006113">
        <property type="term" value="P:fermentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029636">
        <property type="entry name" value="Csf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048636">
        <property type="entry name" value="Csf1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32085">
        <property type="entry name" value="PROTEIN CSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32085:SF3">
        <property type="entry name" value="PROTEIN CSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21678">
        <property type="entry name" value="Csf1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Csf1 N-terminal" evidence="3">
        <location>
            <begin position="26"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1002"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2335"/>
            <end position="2356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1002"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1047"/>
            <end position="1065"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC67272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="3047" mass="339390" checksum="DA7629F10074E17B" modified="2024-07-24" version="1">MAVPDHVNLLLLIELAAVVIGASAFLFYWNRLLGSIVAFFIRLYTWRSYNAYLVIGSLQIAPLAGRISFRDVEYHSSNVSVRALHGHITWRYWKFRIRHETDSESSNKKRNKLPCRITVFAEGVEGFVYNRTPAYDAIVERMKKHEREEAADAKDSSRTSNDSTVEPDSTLRSRFKKVVKTSSRGSATTKEPTSENGHADHQHPPDPDHHNVNLVKPAVKPVPEGVNWFREALPIDLRIVTGSVVLGSDATPMVLIGNFKRAEGTVEVTDSRSSLDLYKTSINLTFHDASVIMRTNVDYSGPLLAHGKKVYDELLKRQPDLTAKPPSTLSIFSGFHLLSKQFKFLHDPKFSTPPVAGLPTDRIWKGLARYREPENGEPRAPKREEREYAKVTTLLETHQLDLTYYADTPGLVPHRSEAPYIDDLDEVGNVDLPPEYGIDIVIHKGNVKYGPWADKQRPRLRPGDTRMHTTFVLHLLLEDETIMRIPTREPSKDWQYDNVSTDVERRYGWLDVVVGPNSSISYTQDQVATKQGYDSMVILQLDSIGISSSLSMTMPTPLEWNAQRDWGMDITLDTASISLLRDHVTLISDLAKDWSSAFMDVYGPRLDAYVAVTSTQYRPEMSTVPFSVSLSDARVELCVPKWDTHRAFGPEVLEIGKIGKLTAKGSYLYYAIPKPDLQETLDLHLEGKHVVFKALGWVLRRLFCVKDNYFGSFTQFRTMQEYLEKFDHDPNSVGDPVEEKYRPGRSNPFAVFVTMNVEESLILMSDEIYNCKKGLVIPVPQLQMNLKSVDHFMELSLDATPTYVIASSDLDKSYARGSCPSISETDTVFVEGIEVKANRLFGPQPYATTYLCLWEVAIPKVTAFLGPELVSVLQAAGRSVGYTFSDHENSPSEIYVPKTPPDAAMNLLERGPRRSWQTVGTAKAGATIDIYKASEGWKEMVAQQQEFLRREDRETSRIWYMYQDSEPSFDQHVNGLYLPLPMIERPHDCRTAEDDESIISTSTSDLHQNESSSASSSASEGDLTESQQVRLPNKRSRSYATARETPDSSSVGDESDTLSSATSMEGSVISEKTPAYGDMASALDSRLQAFHLAHHRHLTSLFQESTLTAHPDDSTIPFPNSMRSNDNGDVIRISGKPIDLDLRPTCIGVLTRVLEGLSTGEKGFEKRLDALLVEQVSSVEGESKTTAPQVFDIRTPLINLRLSLGLSDNTTLSAKMAGLDCHLSHHAPRNKQQILDVKARMTSIAILATASSVPNSDISLRDALNLPDLTSNENPVLKLNIDGLEVAAHQSQGLRVHTKLAHTEFDTVTSAAETLFKLLTPWQEALAHLNLHKPLSNLDAHVLYTILQKAMQNGYDTYLPAFAYERAYGLHVQDFRNIRTQTGWCILERFRDWYRRIPANQDLNLAIPLEQMANFVVQNLCRVEETVHGAENIIREQHFIQSVFGQYVTEAAHTRPREKAMDLFLYSDQLKISHHGPALSSKAVLSSSVFLNKSSIGGSQVVGKAEERPLSQVQLVFAVQEIKTDISDSIIGLVQAALVHLPKNEPAPAAKTRKPMSEDHSTVIISDVQLGAIDLNARGGGLRFHLGTRHLHLTGLSKKSTRNSQASAHVSSKETLNAHCESVMISLLQLEDDPETLADRTIVCLQLEGLSTLIDQINKTGKDQRPEFKLAFGLETLDFDSLPQLKALYSFVQAWKRNELPVSTLEEPSFTSRLATADVSIAAAHLQIRAAKSLWLRWDFGKVYISHSDNNSSTRFAVHADPQVVGAYASVRKQKIKTTDSSTLRLPSIIAVGDLKTIGGSNYVTANVELGFFTGVLKPVILDRLLSLHQQLAADVTEFVNDWRRDMTSAISKRHAKGVSIASTESANSSSHKSKELLFNVQVGVAGLRLGLRADDVATTLLFEALAVKGTATNHLTDDHALHWRAKVDHFGLSLGHLGSQALSNDTEPIRNNRTAYMVLDAEVQEIPATAQMTSKLNVNLCRVHTVMHPEALSELADLLKSWMSDLHALRDHRSAEVAEVKVHTTKVLKRLESAEKVEHSEVSWFANRLVFVEVSGIGIAIPLVEGAAIGATVQSDNPALLYSIRMISFQNRRNETARFKVQNMALQFINKFDQSSPEHFTGDFHESVNRMSLPSIDMEAQMSSQPDLWQLSAHCSATDFKLSLSPDVADGIFKLVDLFHHGKERISKLEAQYKSEMANNPYETVSAKYDDPASPVVTRPSQRILVRMSYTFNSGIVELHRGLSEIDKRTLNADLKKTRQWHDTVVLPTVSLWMDYTGPKTVTPGLDTDEGNDASLIFNAAVHESRNLLRPSILPFFVQLINRMQNRAKDKLATMNSSSQAQLDTVQASRSETPAQTISRTTMEKIKMKFSLRIDKSRLRLSCAPDSNAYVDLKWESGGFLASTTIGGNDVTTVAGTISGVTAYLRHEFAEEGRSCIEAGAKDMAFSIAHRPYNGKGQQKGLSIVVDTQLSGQFRLEQFSAWLTFAAVWIDTAPPLDLPPKSAIVDAASTPAPALAPIPIPHQQKLAIVALVRFRSIDFDANVGVTNAKLELTPIVLRTLSNGEFTEVDLDVGVTQLRAKGEISGELRSEHLNFHTSRQSSRSAHQDVPTVLSMAIDAGDLTGSLKLQELSVITFHLEPAVVRLADDWTAFNEDPTAQVNLSFTVQTGVFRSVARLLAIPALLNKVYSITNTFDSQERVASQRSNTYKSMKLRKSTEPSPMAAAIIHTARKAGQSLNPTTNIRTSQTMRFDLGGIELGIFNAPMSIETRGDFYRFMVGKCESDLKRRLTKEGLPKRDLSVMVSFVSWDTSDGRGAARDSAESAGVKDMIESASKHGRREIAWLPLVNMTMKSIEEPRPPIIVYDFDLVWGEGDGDIQILPYFFEQAYKTFDAFNKGLEQEQITKAKRRGEDMPIRRNTSTVNFDIRASAPTNVYSEITNGQTKGRINGLKNDAQLEDLSAEAENKDEDANEELRFRNRLEGQRPLPVPRLRLLGEGTRQAMDMLPRINEFSDQLPVMIHKGITSPLEDGMDLLLKLYEKQLPDRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8KZF3</accession>
    <name>A0AAJ8KZF3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Multiprotein-bridging factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_100640</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Transcriptional coactivator that stimulates GCN4-dependent transcriptional activity by bridging the DNA-binding region of GCN4 and TBP (SPT15), thereby recruiting TBP to GCN4-bound promoters. Involved in induction of the ribosome quality control (RQC) pathway; a pathway that degrades nascent peptide chains during problematic translation. Required to prevent stalled ribosomes from frameshifting.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MBF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058346.1">
        <property type="nucleotide sequence ID" value="XM_070202245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8KZF3"/>
    <dbReference type="GeneID" id="30169054"/>
    <dbReference type="KEGG" id="kpin:30169054"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013729">
        <property type="entry name" value="MBF1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245:SF15">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1 MULTIPROTEIN BRIDGING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08523">
        <property type="entry name" value="MBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="7">
        <location>
            <begin position="91"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC66735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="152" mass="16136" checksum="1C0F6E44ED1EAF46" modified="2024-07-24" version="1">MSGWDDKPQIIGYKQQRPTVAKGSALNSAQRSGLVVSSESKGAGQTKGPADHQRIAKLDRDDAPKPPEKIGQDVGKAVATARMAIKNAEGKSMTQKELATAVNAQPSAITDLEAGRAVPDQQLLSKLERKLNVKLRGAKNTIGGPLHPPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8KZR4</accession>
    <name>A0AAJ8KZR4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tetraspanin Tsp2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_100297</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058267.1">
        <property type="nucleotide sequence ID" value="XM_070202166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8KZR4"/>
    <dbReference type="GeneID" id="30169397"/>
    <dbReference type="KEGG" id="kpin:30169397"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="64"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="150"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="550"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC66395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="595" mass="66248" checksum="F6A6898716126142" modified="2024-07-24" version="1">MSYDNAGLRRRSPNPNSPLPHLDVDIPYSPALLSPYTQLPGFLNNARNLGLGYNDVLERYSRPSPLMETREHPNPTIRLIPSNRSDNYSPIQATRHGPIASRSRSNDEITSNSADSAESLAALKRHRTDPKSYSNGERASRSEYFESTLFPRIDSKDRPVPPLPLDIRKTKGGPPSIISSRTSSSGRGTGESTIGTSSPRTPRDSDYRPNSVLSSLKSLRNPFSRRTPSSLAPTSPALSARSLTSLATSRSTTSSTSTLAVPFYPSAFYKDEGKFDNLASKDISEKLTNKFPAPRRVKEAEKGRRERWTGYKWILLLSVMTIKADKTVNPHSDVTMVSDPDIVIFLTLASLLCIFTGFIGFTGVLLNSRPILAFYNLLLWPIVLSMCLVGYTSYKRGALQLERKLNQSWSQFLDDQERLTIQNSLRCCGYYNPLHDATYSKRCYPRTTLPGCKSKWIHFERENLHNFATASFSVLGFHFLNIVIALLSSNHVNNTFGKGLTPPAYRLRMSDVRANAVSVLSTLPKLKVRKSSLIRQPAISHKSRPESLYSYSHSKASSRTSTTSTGTPDTVWNAAMHEAGPRGRALREARLRGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L129</accession>
    <name>A0AAJ8L129_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_101064</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014180.2">
        <property type="nucleotide sequence ID" value="XM_019152042.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L129"/>
    <dbReference type="GeneID" id="30168631"/>
    <dbReference type="KEGG" id="kpin:30168631"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048205">
        <property type="term" value="P:COPI coating of Golgi vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08831">
        <property type="entry name" value="ArfGap_ArfGap2_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000004">
        <property type="entry name" value="Putative ADP-ribosylation factor GTPase-activating protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686:SF4">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="9"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="134"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="399"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="199"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="214"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="256"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="326"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="411"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC67157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="477" mass="50728" checksum="7A3D66006AC40A1F" modified="2024-07-24" version="1">MDPTKAQTQATFTHLKSQKANKQCFDCGAKNPTWTSVTFGIYLCLDCSSVHRNLGVHISFVRSTNLDSWSLQQLRTLKVGGNQAIREFFTKHGGSNLLPPANSDARGRYTSRQAGLYKEELARRIAEDATRNPHGIHIDGLELTPLASPSKTAGDEDFFSSWDKPSPASSKPASPAPGSGNKASAPPSIGNGAKPAATGSRTVTSSSLRTGVNATRPAASSRLSSSTTPSSSTASGGGKLSKLGAKKAVTSINFEEAQRKALEEEERIKRLGYDKKKEEEEAKALKEREAEEKRKAAAATASSSRSSTPISSVRREESKPAPVRLGFGQTAGQAAPAQTKTRAAVVDDVHVARDKFGGQKGISSDMYFGRGTYDPQAANEAQTRLRDFQGATAISSNAYFGRAEEEEDEQGNGGYGGGAAGGDGLMDNETMQGLERGIRDMAGRVLANPDVQNLGDQIRMGALKLSDYLSSFEGQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L2Y8</accession>
    <name>A0AAJ8L2Y8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginyltransferase</fullName>
            <ecNumber evidence="2">2.3.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_101889</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the R-transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.8" evidence="2"/>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC67970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008461.2">
        <property type="nucleotide sequence ID" value="XM_019158715.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L2Y8"/>
    <dbReference type="GeneID" id="30175389"/>
    <dbReference type="KEGG" id="kpin:30175389"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004057">
        <property type="term" value="F:arginyl-tRNA--protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030700">
        <property type="entry name" value="N-end_Aminoacyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007472">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007471">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367">
        <property type="entry name" value="ARGININE-TRNA-PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367:SF1">
        <property type="entry name" value="ARGINYL-TRNA--PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04377">
        <property type="entry name" value="ATE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04376">
        <property type="entry name" value="ATE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-end aminoacyl transferase N-terminal" evidence="6">
        <location>
            <begin position="18"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="N-end rule aminoacyl transferase C-terminal" evidence="7">
        <location>
            <begin position="187"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="103"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="396"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC67970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="494" mass="55873" checksum="4F48F905BBD0F6D5" modified="2024-07-24" version="1">MSSVFSTLLTPYGYSSGTCGYCSPSGERSKGKTSSKYGMITSQMTPEFYQLLINKGWRRSGDYIYHPDMARTCCPQYTIRLNTKTFKANKKHRQVINRFNRYLETGQKPGESSTSSITDPQGGKQSTSYEEKILKGKGKGKGKNNTNSIGIIDELHKFEIGYVAEEEEKELSHRFTTQLVPAKSTKETFELYKLYQIVIHKDKPEKITRTGFDRFLCGKTLIQTPINYKMKVDQEIQDGKLPKTYGQYHLLYKIDGILIGLSVIDILPCCVSSVYFIWHPDWAWASLGKFSALYEISLSERMREKGIEEMQWVYMGYWIPDCQKMKYKSEYSPSELLDPGTNTFHLLDIKLESFLIANPSGYFPFSGIISSSNSHTSLNDSTDLAKVKTKGYELSIDSGSESEDEAPSSWPVPTPPGFEDPSNISDEQLEQVILLMGRNKFTGQGGSLIPIINLEFRDQEVMYREIKEFLAAVGRDNIASLINGVADKAILHFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L3E3</accession>
    <name>A0AAJ8L3E3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_103807</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC69864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058934.1">
        <property type="nucleotide sequence ID" value="XM_070202833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L3E3"/>
    <dbReference type="GeneID" id="30176128"/>
    <dbReference type="KEGG" id="kpin:30176128"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WWC69864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="442" mass="51233" checksum="25BA29D0E496D670" modified="2024-07-24" version="1">MTQHPPNMSNTGRPPVHPHSWREIINGSLEENFVSMALGTFNELIKINFIPTMSREHIQLLLYLTTGPVDRAISKRALNILHKLLSLHQPSSISQALPFHPSASKSKEDTPVWLQWDYKRSDLHKSVWKRMKECLDEGIWALLWEYRAKDATDIKKRKHRGDIDDDTGDYEEEGDRKRKVSENGWNLLGWLIEFWEKDKLENSAGQIGYSPLFMKQLPRPFDRSGQLPRNDASVPLFILKSACTFTGLGSSETRDSRIALAVKLLSLVIDATSGPIPPFHPESLSSSILHTLQSHSTSDVQRIIKGLETLGHWRASTHILTLLIESLGATRNMKMQDRKAKHQFEYDSQYRLNRPDIRYLLQQILLTSSKENNEQSKICIYKVQLLRIITTHRSQIGNEEEMREMHRIRDDSRWWADFDRTNELEMIDLKRVLESCIKSFIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L3E6</accession>
    <name>A0AAJ8L3E6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Complex III subunit 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I206_102622</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the UQCR10/QCR9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058696.1">
        <property type="nucleotide sequence ID" value="XM_070202595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L3E6"/>
    <dbReference type="GeneID" id="30171345"/>
    <dbReference type="KEGG" id="kpin:30171345"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.260:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.260">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008027">
        <property type="entry name" value="QCR9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036656">
        <property type="entry name" value="QCR9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12980:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12980">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX, SUBUNIT X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05365">
        <property type="entry name" value="UCR_UQCRX_QCR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81514">
        <property type="entry name" value="Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC68688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="67" mass="7829" checksum="B567EC75B4D82129" modified="2024-07-24" version="1">MSRVHDLIYNTFFKRNSAFVATCFVGAFAFQISFDLGTTAWWDYHNRGKQWKDLRAKYIQAGDSAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L4K5</accession>
    <name>A0AAJ8L4K5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_102976</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="WWC69040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_070202658.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="30171698"/>
    <dbReference type="KEGG" id="kpin:30171698"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AtrR-like"/>
    </dbReference>
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        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
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    </dbReference>
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        <location>
            <begin position="20"/>
            <end position="62"/>
        </location>
    </feature>
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            <begin position="108"/>
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    </feature>
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            <end position="123"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC69040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="622" mass="69330" checksum="B0DA3C13A4C7685E" modified="2024-07-24" version="1">MATRVQPQASTSTPPKKLNSCDACRSRKIRCDRIPIAEGISAEPHIPPPCKQCEGLGIECTTTWRPKRRGPPSEYLKKRLAANNAIVNGPTYDNPQASSASSISIESLTSPSSNVYPHTQSNPYPYHHQNGYQPENTLRPETHLRSPKTFTSLSPISPQSYGQTHYNPSVQFTSLDNVLGRDVAMYIFSLFFDYVHPLTPCLHRPTFLMEVETRRDEKDPVFLSLVLSVLASAIVQIPKALLPPINNVPAREIADRCYQVSRLVSLNAYDPPTIELVITRFLDAVYHLVSGRLGAQAACLGEALQVGVSLGLHRESSYVGLDPITTEVRRRMFGLIFHSDKSAACLRDRPMFLATEECDTQMPKEVDDEWITRTEYLEFPPGRTSTIAGFKIVGDALVLRRTVRREVPLTPESILAYLRRLELIADDLKAVLKDIPPALRLEETPAPLEIPETNQEWGQDILAQLDVYFTNAHETRSIAKESFLVLKGNIYVTHALARYVLLKCRDEIVEQANPDGGVELSVTARMVKLFTGRQDRYEHIVLDLLKALHSIPIQNLAVNGPSLVNKVRYVAVALLDALDAQNPVSPEGAYLLDFLGILSEIEQVSLPHSELLSIAVEYSGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L6G7</accession>
    <name>A0AAJ8L6G7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Striatin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_104389</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat striatin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059041.1">
        <property type="nucleotide sequence ID" value="XM_070202940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L6G7"/>
    <dbReference type="GeneID" id="30172399"/>
    <dbReference type="KEGG" id="kpin:30172399"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013258">
        <property type="entry name" value="Striatin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051488">
        <property type="entry name" value="WD_repeat_striatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653:SF0">
        <property type="entry name" value="CONNECTOR OF KINASE TO AP-1, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653">
        <property type="entry name" value="STRIATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08232">
        <property type="entry name" value="Striatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Striatin N-terminal" evidence="9">
        <location>
            <begin position="96"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="518"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="573"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="626"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="789"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="52"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="159"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="284"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="459"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="114"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="186"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="331"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="459"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="472"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC70438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="870" mass="95848" checksum="D97B611CFC706E43" modified="2024-07-24" version="1">MFRNVEQHQQQQQQQQSYPPPQPQGQQQQRNNNLYHNTQPQQYVRTYNNDQQLQQQSQNQNQQNQQQQHQQGSVSGGTIDGGSGSNGGNGPQEMNLASVLHYLQSEWRRWERDRNEWEIERAEMRARIALLEGQRRSAENLKVDLLRRVKMLEFALRQERTKTVNSSSGSGKVSSIPPSKLAALQDEDRLSTGSKDETKEGSGSEGSQEDFVERSSAPPKTNGIHPAAISKSPSTSILPFKQSTMDSNASSAWKSIGSAPRDPKSRARSREYLKQCLQEISYLTSPGALNPLPPKPPIDPSYPIPEEEQSNSSEHQPEPADRPTKALPEQNIPSIFVKTQPSQAELTSQNHQELPNGSSSSHEQEQSRTSSEPTPNAQAQSSEMGLDPTAKPPSSPAPRTLSLPSENPSQGEPPKPSLNTDLPPDNAQNDDEGKQILTAIYRPDSKAAWREELRNANEMAEKAKEDRKAPISSASSTTDEEQQLSSLTLNDDEESTKNEDSSANGLVDEKVWTTRRSLKSHLDTVRAIAFAHGPGVMLVTGGDDCTVKVWGMEVGSLINHKSSAHEIEPLVTYRGHTAPITSVVVSKALSTIFSASLDSTIRVWKLPSIHHDPYSNYDSTTSIQTLEGHTDSIWDLVLLPSRETNNKQVEEKLVSASSDGTIKIWTSSSIKAQERRQSNGPSSTQNWKLKSSYSDFFKSGEIPTCLEICQSDYGNVYIGTNKGRILLLDTDKDEGKILQVFGEESDDENAQINAILSHNTLPAIATGGEDGYIRFYDIKSASIIPTHSILAHPSSITSLSISPFSPTCIFSSSIDCLVRLWDLSKKTCLQDLNGHRIKSGQGVEKVTAHPELPIIGTVGSDGVVKLWSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L6L3</accession>
    <name>A0AAJ8L6L3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_103743</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MNN1/MNT family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058926.1">
        <property type="nucleotide sequence ID" value="XM_070202825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L6L3"/>
    <dbReference type="GeneID" id="96955738"/>
    <dbReference type="KEGG" id="kpin:96955738"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC69800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="390" mass="43800" checksum="994099EA95D9C0E3" modified="2024-07-24" version="1">MNSSSSKSSSSKANRRYPDLHINLSSPSTSYSSNQGGSKHNLEVISPTNDFRSRSRSPSRSTGVNLDIDIPPVPDSSALPSPSNPFQYEFSPSPESFLSPSSRFIDPARYELKRWNRIIMKRNCQPTPLGYALLSLTILSVLYLLSGSNNDTHLLPSSWSSTPSTNELPYDDLEHPEDDVGTIEQPDLPSLPSIYSSHFPSLSLPLSFDVPKYYHLSTKLTQFLYRPVQAHDEAKESNYEGCPRELSDKLVNPDQYNGDAQFWIEDVKEEEIAKRRYDVVRWLEEAIERGEEVIGRKDGSTGKGRGIVLTGGNQDTTLRTITAIKHLRRLNVDLPIEVFHYSDELTDGNQRGEIENLGATLREAKGLSKVEGVWKNWQVSVVHTVLSLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L758</accession>
    <name>A0AAJ8L758_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AP-1 complex subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I206_104287</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit APL4 and beta-type subunit APL2), a medium adaptin (mu-type subunit APM1) and a small adaptin (sigma-type subunit APS1). AP-1 interacts with clathrin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010833.2">
        <property type="nucleotide sequence ID" value="XM_019155875.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L758"/>
    <dbReference type="GeneID" id="30172505"/>
    <dbReference type="KEGG" id="kpin:30172505"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016482">
        <property type="term" value="P:cytosolic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000030">
        <property type="entry name" value="AP-1 complex subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017107">
        <property type="entry name" value="AP1_complex_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037094">
        <property type="entry name" value="AP1_complex_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GAE" evidence="12">
        <location>
            <begin position="739"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="607"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="693"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="607"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="631"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="655"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="699"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC70337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="859" mass="94030" checksum="76DBE2850ED93F1D" modified="2024-07-24" version="1">MGGHYNLKALIKAIRSCKTLADERAVIQKESAAVRTSFKEEDSFTRYNNIAKLLYIHMLGYPAHFGQIECLKLVASPRFADKRLGYLGIMLLLDENQEVLTLVTNSLKNDMNHSNMYAVGLALCTFANISSEEMSRDLANEIEKLLGSSNTYIRKKAALCALRVIRRVPDLMDHFVSKAKSLLQDRNHGVLLAGITLITEMCELDEKVCDEFRKATGLLVKHLKNLVTTGYSAEHDVLGITDPFLQVKILRLLRLLGRGDPASSEIMNDILAQVATNTDSTKNVGNSILYETVLTVLEIEADSGLRVMAINILGKFLTNRDNNIRYVALNTLNKVVSIDTNAVQRHRNTILDCLRDGDISIRRRALELSYALVNESNVRVMIRELLSFLEVADNEFKLGMTTQICLAAERFAPNKRWQIDTVLRVLKVAGNYVREEVLAAFIRLTCHTPELQFYTSQRLYAALSNDLSQESLTLAAVWIIGEFGDVLLQGGTIDDGEEVKQVTDTDIINLLELVLSSPYAKTLIRQFVLTALSKLSVRFSELSTPQQSHNQDRISEILHRFSSNLELEIQQRSVEFSHLFELANVKGGVLERMPPPEIRATMMGTVSERRTVGSTRTDKDTVVDLIGDDLTSPTNGSSSATSGPSTQDLLADIFGTGGGSDLGGLGSPTSHANGGGQQKSAAADIMSLFDSTPSAPTNVSSPVTSPIQSSSASGSGSLFDLVTPSSQQPAAPPSQQPKSQLQSYSAYEKNGLKITLTPKVSPTQPGVIQILARFQNSNGENVSGVNFQVAVPKTQQLQMQAMSSSDISAGSTETQQMRINVPAGAAIRLRMRISYTKSGQNITDQQDFAGFPADLTGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L7U5</accession>
    <name>A0AAJ8L7U5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_106241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059378.1">
        <property type="nucleotide sequence ID" value="XM_070203277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L7U5"/>
    <dbReference type="GeneID" id="30173436"/>
    <dbReference type="KEGG" id="kpin:30173436"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC72279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="303" mass="35640" checksum="DC6727162C63C8C9" modified="2024-07-24" version="1">MAPLDIGGIAETAVNGAAGAIETATKGADGVAKTAAGAVSTATNAVNNVKGQYDDAKGMLGMFTQIQGYITKIQDAWDKYQYLIIFVVCLIIFIYISITIYCCYHFMIDCFHFSCCYINFIYKIERYLWKNRNKKLINNYLCKICLINSNDKNKNKNEKENYHKFSKICLKFIPKKIRIELEKQHGDLRKGWFDSTYFIRQCGRIELPNEPEERIKWYWYGHENSKIHKILKFCFLPKNYKEKRLEKEFEKENKRSKYFNNLIKGEDKLGYKSSDWRDRVNRSWLKEKERDIKGSEINSYLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L9Z6</accession>
    <name>A0AAJ8L9Z6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_106921</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC72957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059527.1">
        <property type="nucleotide sequence ID" value="XM_070203426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L9Z6"/>
    <dbReference type="GeneID" id="96955779"/>
    <dbReference type="KEGG" id="kpin:96955779"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38052:SF1">
        <property type="entry name" value="ABM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38052">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WWC72957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="95" mass="11097" checksum="A6CADABA31D06140" modified="2024-07-24" version="1">MGFIVVLFLEFPADKVDDIKSKLLNAAAIYRKDPETVEWNVQQDLTDSKKITLVEKYERESSLTDIHRKNPIYQETIDLITSNVSKPIEKHFIHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LB51</accession>
    <name>A0AAJ8LB51_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 13">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="8 13">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">I206_106558</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="15">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate degradation; pentose phosphate pathway; D-xylulose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 13">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="8 13"/>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007915.2">
        <property type="nucleotide sequence ID" value="XM_019159243.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LB51"/>
    <dbReference type="GeneID" id="30175920"/>
    <dbReference type="KEGG" id="kpin:30175920"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000171">
        <property type="entry name" value="Ribulose-phosphate 3-epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004076">
        <property type="entry name" value="PRK05581.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01163">
        <property type="entry name" value="rpe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="RIBULOSE-5-PHOSPHATE-3-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
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<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ8LBA3_9TREE</name>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
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                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
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                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
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                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
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                <person name="Roberts A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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</entry>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8 10" id="KW-0103">Bromodomain</keyword>
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    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="133"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="15">
        <location>
            <begin position="187"/>
            <end position="299"/>
        </location>
    </feature>
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        <location>
            <begin position="495"/>
            <end position="565"/>
        </location>
    </feature>
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            <begin position="306"/>
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        </location>
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        <location>
            <begin position="644"/>
            <end position="689"/>
        </location>
    </feature>
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        <location>
            <begin position="701"/>
            <end position="1050"/>
        </location>
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            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
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            <begin position="326"/>
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        </location>
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            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
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            <begin position="648"/>
            <end position="657"/>
        </location>
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            <begin position="765"/>
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        </location>
    </feature>
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        </location>
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        <location>
            <begin position="868"/>
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        </location>
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        </location>
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        </source>
    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1172" mass="130671" checksum="7D4F78744D644222" modified="2024-07-24" version="1">MPLESNADKAYMHDLPKVSFRVIDEDPSLLAPAGVQSEQSRSYGYNDFSDFTRSEHYIRYIEPIESELAVQVEYDMDEQDQEWLDAVNAERKKDQSGPISYEIFEILMDKLEKEWFNLSKRIPQPTQHLPAEDSKCAVCDDGEGENSNAIVFCDGCNLAVHQDCYGVPYIPEGQWLCRKCTVSPENPVSCIFCPNEGGAFKQTTTGHWAHLLCAIWVPETGLGNVVYMEPVEGVENVPKSRWKLVCSLCREKTGACIQCDNRNCFTAFHVTCARQVGLLSSMKSFNQDGVLKAFCHKHLPADSIEETETASDYSSSYSETLPPKATKTKNKHRRSSQSHHGTTQVIAPTTKKSAQAHSKSFRPGPPIIPRLILDKVLDYVAKVVMRKRQPFVERLCRYWSLKREARRGAPLLKRLHLEPWTASAASRQQTDAEKAQKLKFLQFLRNDLEKVRMLAELVRKREKEKLRQAQAIKDVVDGFIFPHHGRLRVALERISAMDRSELYLNPVSRLEAPDYFEVIKDPMCWLWIDEKLEKNEYLEVAEFKRDIMLVLDNAMLYNPKDNPYHRKAAKIKKEAEPILADLDGITETARAALGDQNLTESNKSPIGDLEPVGTVLSTLLLESSGHHDPSQDYLCSIFSFELEKPREPTPPPPPKPAKAPRKSNAERRQQWEARDAAAKERSLAGSRPTRAALAAEKVFNQEAGIQPASPAPIETKVEGLDARSRRRSLREINGVEGPTTPATSKKAKGKAPASTKPPSGRKSDTIVNTNLQKSKSTSLTISGSASPTKSTNSFPSRHKSQPGVAGVETFQALTDRERREQEKSLDLLTQEVGAQDQFKRFNVGWVLPEGSKRKRSERTSDSIPRAQSSSSSRKPPSASTSKPRASTTPRTMHLSLSPITSQPAEPTSVQTGSGSDLSSPPPSSTVTSAAPTPVKPEKASKRKAASPEEASTPRLSKRARTTRNPQQDEIEQVQDEDEDMTPIPDDTANADAEDAKGQTPEEIEEIEDSQPATHTESGATTKSSPAKLRRGQAKTKTVSMSPIQGEGPVDDDIYPPGTLVHSFPYFPAEVIDPTDTEEIPSAVLYAEEKERAAAKLLNKKIWLVRFYDNTASYGWVMEDKLDLLGEDQDIDAMYLSGKDRGKANKYKHHAIKMVKKGYREALASLQSEEEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LE31</accession>
    <name>A0AAJ8LE31_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_107476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_070203526.1"/>
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    <dbReference type="GeneID" id="30174174"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR055334">
        <property type="entry name" value="PEX8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39214">
        <property type="entry name" value="MICROBODY (PEROXISOME) BIOGENESIS PROTEIN PEROXIN 8 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39214:SF1">
        <property type="entry name" value="MICROBODY (PEROXISOME) BIOGENESIS PROTEIN PEROXIN 8 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <source>
            <dbReference type="EMBL" id="WWC73505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="597" mass="67118" checksum="03F05E6F97936EFA" modified="2024-07-24" version="1">MSSVSGLPTPQASDTLDLLPQFLDILRSSSPNSIPPQTLLGAITHFLSQLEPPYLEEFTQALICSPSIWRNADINRSDLRNALRLSVSSKINKISQDTRNVYFADSRKRRKAREWLDCLNKVSSDSENTSRKLDLYLGLLQGVNDVEEIDWGKGKVKLEEEVVMALSQEPQNPVLDDNLAMCAALPLINIDRLRILDIQSIANNLESSMLRRFRPQENTASADLPDFARALGRSFEVLHSGGPSSQENARQRMMKFCERIEARGTEMERDWEFHSEKSEDAKFEIHSSNFAAFLAVASTMIDILLAGDVTSKVVDASSIEVAVHILAGLTSFAYLTDASDGGFEDYYKVFYGSLDIISAQEGNEAIRTLFSSIARGNRLNDGRAAYVLVLGDELMKHLAKKEIDMLLTLAERHIYRPKHKASFEASHAFLLSLIKSSADSLENDHSQAAFFDAILLNYLSILNKQYTHKEITSDQFRQAFLILVETSSKRSSASVQLCISYLLALPTDKEIRRIRVDITPYINSANLPQYLDNLAQAILSTEKYSEERTDLTKDAFEMVVKGLSDADKQVGIQWWTRWRAEFVGGRRSDPGLIRSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MPX1</accession>
    <name>A0AAJ8MPX1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_104048</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058975.1">
        <property type="nucleotide sequence ID" value="XM_070202874.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30172745"/>
    <dbReference type="KEGG" id="kpin:30172745"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF81">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="389"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="144"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="261"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="454"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="550"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="565"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC70101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1293" mass="144141" checksum="18BC9948723BC1E0" modified="2024-07-24" version="1">MNNSPYRTIVPPDRRSSTTRPPHPPLSYNSNVGDTGLTSRTGDRERGDDGISRNIEHNEHRNFPQSTQATLPQQYQHFSSFASSSQPLQTLQPLIMPSRPQPSSQFNPYNDPHYRSSSHGYSETMQPLSSPIAPHRYDFLPHPPSYTPSASNSEMQPWQYGGNTATYDPAISSSSRRRESMPDIENKEDPNPLFSNRPMMGAPSGPNQMISGTSTDADTKNPNLQSYIHSLTGLVQTSPVQATTNPSASASLTNFQAWQPISQQRHQQQQQQPLAPPAQSSSTPLNTQKRKRSRASTFGSKTTDDEAQIKSTHRPSVDDGDDISSRPTTADKGSIAGKDRSLQPLVSTKDFTQPPAINEGPEDAEHNQGGEDDEKMDHRKRKRNRTIRSCVPCHNHKRRCDRKRPCSRCTSLGLTGTCVYEIDEQRNMNDPDVIESERLRRRIAELEQVVRELRQKPAARPQTQQSNAMIGSSTTATGNNSAEESAGEDKKRRVIVDRFARFKLDEAKDVENAAAAAGSRVIAPDPPVWAPQTIISARSPRPEYQPFVAQRETKGSINSSIDSSSLKEDPAGHQSDYKSEPYQTYLLPGEEISSDITGRKVYLGASTGKSMLRRLGELAKDKGDGQLLSVPEDIAFTGVFPDLRKTYPFTTIWSHENFSAEIIGLLPNSQQAQWLWKAWEEEHGVYVNPFHTPSMHAEYSAFFAMSTKDKMNVPLASLSLYLIICALGCVIRATSQELFGQPDPARVKDLPARKPSLTAYKDLTSSRLQSELYLSASFHALRLCAYLANPTMRTIQAQLLQMVYLLASERAADAWTSGGTLVKQAIALGLHKDPLNLDPKISMRDAEVRRRVWWSIAGFDCMLCVFFGRPSTISYYTTRLPQDRPDANLSDIPGSAQQLLPPSNVLSNETTEQTFHAAYYQLTIPSFELLDRIFTVDRRFSRSSIYGWFSPPQKDDTKARFMNYQDDEQNTDHTYQDAVRLANDISQWYSLLPSGIRFSENDTPEYLINSRSRKQLNQTLILSIKTWTIVMVLHRPYLRLDPTAYPESTELCTQAAHLMLRTYKSMADTKSTISWSFWTMSYRAFQAGAVCAFLAIRQPGSPLAEKCLSDLRGGIRIFEDRLSTWNATHPVQADLCEGLVQLEKLVTAATNQRNTPARSLTPHVNITYDPTSSFGTPLSQIQAFPPVTLPPSSRNNPGPNTLFPESITGLAHNPHTMLYGDSQRPEQPGNAGLGGMVVNNYPTDHLVGQLGGDFNGPEPLALSQFWANMFGIRMQNEKDSAAFTSDSTATTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MQL0</accession>
    <name>A0AAJ8MQL0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7137 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_106233</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010585.2">
        <property type="nucleotide sequence ID" value="XM_019156783.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MQL0"/>
    <dbReference type="GeneID" id="30173428"/>
    <dbReference type="KEGG" id="kpin:30173428"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055561">
        <property type="entry name" value="DUF7137"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42028">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42028:SF1">
        <property type="entry name" value="YALI0E30657P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23585">
        <property type="entry name" value="DUF7137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7137" evidence="3">
        <location>
            <begin position="35"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC72271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="216" mass="22737" checksum="4FF9B3AF8718A7A2" modified="2024-07-24" version="1">MSQSVSATSRPNASGSTSTSRNGSSSTTSISIPATAAAGGITVTQPPSTASASYYKIAKDNWITFGWNMTSLYVQPKSLTVVASCSANGNIYPVGPSPTASGNTSANVFPGNTTQVVWNPYDWEQIPGQVPFAEATYVLKIYDERGDGSAVKGGYLSPYAGTNFMMYRPGTYTSIADGWTCSTCSNAFGTFSQPVPLAIFTSLLITILSAWGILRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MT48</accession>
    <name>A0AAJ8MT48_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pre-mRNA-splicing factor SYF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Pre-mRNA-splicing factor syf1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">I206_107446</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing and cell cycle progression.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059621.1">
        <property type="nucleotide sequence ID" value="XM_070203520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MT48"/>
    <dbReference type="GeneID" id="30174143"/>
    <dbReference type="KEGG" id="kpin:30174143"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000023">
        <property type="entry name" value="Pre-mRNA-splicing factor SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000137">
        <property type="entry name" value="Pre-mRNA-splicing factor syf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000038">
        <property type="entry name" value="Putative pre-mRNA-splicing factor SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056350">
        <property type="entry name" value="HAT_Syf1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23220">
        <property type="entry name" value="HAT_Syf1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="16">
        <location>
            <begin position="175"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor SYF1 central HAT repeats" evidence="14">
        <location>
            <begin position="411"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="15">
        <location>
            <begin position="571"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="998"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="497"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="388"/>
            <end position="398"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="714"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="810"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF46132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC72567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1447" mass="159589" checksum="E00FCFBAC6FAD7A7" modified="2016-11-02" version="1">MSGPPGPSRLPSSTSPTRPNLPLISTSREEAERFFAQLEASSDRKTSGPSDRKPFLSNNSQNRVSQSFNQKSQASVIKPRPDHLFTGSASLKPNKGKQKEVIDLTLSDTDDEVIIPLDSNMKPIVKMEKSRVSDRRESLASDHAGSSRFPEAENSQHRIKLPETQLGPTTSRKSPHSITYNTNANGLSPQEAIDMRSPPWNPPTISHVPLQLLGDGNSMVGRTKRAFSRTPSGSIPMSFSPQKKRKIMPPQSEKHRMSKAEWDAAIDEKKRLDDAKKAMLISSQRANGERGISMSRSVSKESVKTASKSKAHLPSPLKTPMTLPSTTTSPSKNPSPDSHLGTHPPSRATYPLSKPTEPLGSTSLTAVNFPSGSSNVPKSTPNLFEPSKNYNTSSQAGPSKILAPISNKPRQVTSTKSQSSSSQPMPKQPDGHVRTSSRPRPAPGAYTIPAADTPMDEWPRIDSTHSAGSSGTRRISGGSPIKLKNNQTEQRKSTVARSTKKDLPKVFPAKSTDATPDISRKSHSINKQSQISPTKLKSSNKRTPRTPGRDDNSSRRSTSSQLTPLPSRTASPANPSPVKSLSASPVKGRPFPRLLGDETPLPKDRAPVVISESKETHQEEEADIKPLIDPDAIFAEFDDFKWTNDEEEPINHPGVSGTAAETVDQDIITQTDSADSKPIQTDKVGEMSTPSETLTTPRSAPEIKSASPPPVSPNKRDTEPDKWQQLLEERKAEEEQEKEAERERERRMEAEFQATMGDKQDEGEGGASGESGDLTTFLDDINSKPNEPTKLRSPSPIKPDFKSAVQSRSESNKAKKEYEKAAKRKAKLDAIHKAIQDENARKYKNENKEFAKILKGIDQSNEFDEVMNDILASNINANLLKDRKTVENAYPTPETDLDVAGQRSGNTDDESEEDYYIDPENLDRVLDDSFSQRHINDPAKLENMIHDLKTKGVGVDDNLVRDIKVGLKQQSLAESELSWEGFWEDDHPKPEQLNQRQFIPFDPSSTVQDPILRVIIDMTSQSDSPLDLEAVSTVVSSGTLQFVKEKRREIGLMLLNNAISSSDISWSYTARSAFIDLSQIQGYFQTADLYDFVEIGIATLLTLGARKTILGPVIKKTPIVEAESRSSGLSIIRETGCALICRIIIALTKSSSSKVETQSILNWLPILLLLSVDSSTSSTLNRIIGDTIQILLLNSFDSSDDVFEQSRKIALSIASSSTTYPVVVKVAILESLGQRTNESSMVHKWLGMEFLSPGSLDQTEDKPSVPPVRYLLSSIQSLSDEIRPMLSADNTDKEEPNYDHINNRVTFLYAAMSDMAGLVKEMNIDFEDNIDNVKELIENCEVERVREGLRKCRDLLSDQSNGTLKAVVKARLHQLYEITRLTLTLEIKKNIRSNRLGKNLKVGSKGQTQLNFGKIIQNVEAESQVGIEMERKNSINGEGEDVEMLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HSM5</accession>
    <name>A0A1B9HSM5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Multifunctional tryptophan biosynthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="16">Anthranilate synthase component 2</fullName>
                <shortName evidence="16">AS</shortName>
                <ecNumber evidence="16">4.1.3.27</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="16">Anthranilate synthase, glutamine amidotransferase component</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">Indole-3-glycerol phosphate synthase</fullName>
                <shortName evidence="16">IGPS</shortName>
                <ecNumber evidence="16">4.1.1.48</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
                <shortName evidence="16">PRAI</shortName>
                <ecNumber evidence="16">5.3.1.24</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="21" type="ORF">I206_07752</name>
        <name evidence="22" type="ORF">I206_103803</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="22" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 16">Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 16">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="16"/>
    <dbReference type="EC" id="4.1.1.48" evidence="16"/>
    <dbReference type="EC" id="5.3.1.24" evidence="16"/>
    <dbReference type="EMBL" id="KV700118">
        <property type="protein sequence ID" value="OCF46275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC69860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007494.1">
        <property type="nucleotide sequence ID" value="XM_019159442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HSM5"/>
    <dbReference type="STRING" id="1296096.A0A1B9HSM5"/>
    <dbReference type="GeneID" id="30176121"/>
    <dbReference type="KEGG" id="kpin:30176121"/>
    <dbReference type="OrthoDB" id="524799at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000136">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000031">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016302">
        <property type="entry name" value="Anthranilate_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045186">
        <property type="entry name" value="Indole-3-glycerol_P_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854:SF2">
        <property type="entry name" value="INDOLE-3-GLYCEROL-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854">
        <property type="entry name" value="TRYPTOPHAN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001382">
        <property type="entry name" value="TrpG-trpC-trpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 16" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8 16" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12 16 21" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 16" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="18">
        <location>
            <begin position="5"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Indole-3-glycerol phosphate synthase" evidence="19">
        <location>
            <begin position="255"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="N-(5'phosphoribosyl) anthranilate isomerase (PRAI)" evidence="20">
        <location>
            <begin position="604"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="213"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR001382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OCF46275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="WWC69860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="786" mass="84810" checksum="00BC1EEFA9D32DAE" modified="2016-11-02" version="1">MGITLLIDNYDSFTWNVYADIAVLGGNPVVVRNDKITLDQIETLFNSGELERIVISPGPGHPRTDSGISRDAIKWGIGKLPILGVCMGLECIVDLLGGEIAYAGEIKHGKLSLVQHDSLGIFHDLPPLLSSVRYHSLSAQLLTLPPILQVTSTTQESGVIMGVRHREATVEAVQYHPESCVSEGGKGLMANFLKLKGGKWGGENAWCGVEPNPLAESSTSSQEKAGSLITNGSAEPASSSSSSSKSSAPSLPTILNKIHAQRLLDVEETSSILATTPTNISTSLSLHTSASLISLVDRINNTPHTAVMAEIKRASPSKGDIAPDASAPAQALKYALAGASVISVLTEPKWFKGSLVDMLAVRNAVNSLPDRPAILRKDFILSKYMIDEARLYGADTVLLIVAMLKPDQLKELYDYSVSIGMEPLVEVNNTTELQLALDIGSKVIGVNNRNLHDFNVDMSTTSRVNAALNGRNVILCALSGISGPEDVEKYVKEGVRAVLVGESLMRSKDTKQFLRSLIGLKEPKLNSIQNPMVKICGIRSIEDAEIAIKAGADLLGVIMVPNAKRKISYQIAKDISKLVKQVRLNSKQTLITETENENDEITNNNEPWFTFNAKNLNKRKKPLLVGVFQNQSLNEILNAINEIEFDLIQLHGEEPVSLSKFIPLPIIKVFKVALDGEIPLDKEISRPGENNFILLDTIGKGGQGKSFPWEISKSIINKGENGSQGYFKLPIILAGGLNSENVKKAIEQSGGGGSNGIIAVDVSSGVETDNKKDEKKIIDFIKAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HTE2</accession>
    <name>A0A1B9HTE2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_07382</name>
        <name evidence="6" type="ORF">I206_106730</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI894016">
        <property type="protein sequence ID" value="OCF46529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007748.1">
        <property type="nucleotide sequence ID" value="XM_019159076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HTE2"/>
    <dbReference type="STRING" id="1296096.A0A1B9HTE2"/>
    <dbReference type="GeneID" id="30175751"/>
    <dbReference type="KEGG" id="kpin:30175751"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF7">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="42"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF46529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC72766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="171" mass="18839" checksum="93D61C580737CA9E" modified="2016-11-02" version="1">MPRTQLPASSRDYSPSSGQERTSQLIHVQYDLGPNAGIRVSPLCLGAMSLGNQSTSFMGSLLDHEQSAKFLDYYYEAGGNFIDTANTYQGRFKSPEENEKGQKEGKFRAGMEPSENEIKISRALQDVANEIGGETKLTSVALAWARQTVAYCFPIVGGSSIEYLKSTMHLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HTE5</accession>
    <name>A0A1B9HTE5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rab GTPase activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_07396</name>
        <name evidence="5" type="ORF">I206_106715</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894016">
        <property type="protein sequence ID" value="OCF46543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007762.1">
        <property type="nucleotide sequence ID" value="XM_019159090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HTE5"/>
    <dbReference type="STRING" id="1296096.A0A1B9HTE5"/>
    <dbReference type="GeneID" id="30175765"/>
    <dbReference type="KEGG" id="kpin:30175765"/>
    <dbReference type="OrthoDB" id="10264062at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000077">
        <property type="entry name" value="TBC1 domain family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF502">
        <property type="entry name" value="SMALL G PROTEIN SIGNALING MODULATOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="511"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="275"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="411"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="535"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="607"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="853"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="411"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="431"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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            <begin position="540"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="879"/>
            <end position="895"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF46543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC72751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="913" mass="102295" checksum="E6B3891C34DE3040" modified="2016-11-02" version="1">MAESSNPNLTENRRSTSSDTSSLINISSTQAHSPATTNTSFDHVSDHPLAASLKDASNNGGKARLLYCKSHVSIHPTSFNKDNISGYLGIVEVDHSTPHSLAPNLESSVENGQKETLITWVPNELLDRMDEKDRQGYKTMEGRTLAQNAEEEEDGFVFVSLPPPKGEKYAFSIPITSIYSILVYPPSLSHWYGSATFNLMGGISLPTLYFHDDESPLLASPNPPNPLQPLPRAQWGFPPFLSLLESRATFVRSRLLTSKKNMGAELWLVNPSKSDREVHEAGLEEEPETVPIQRKPAQSTQPAPYPPKQTYPNSAVLNTATPKQTLMTSLSNLTNLSRKAASQVLSHPLAQPVVPHLPPAVRSLVNVPGEWERTGRLPPKTGKKNNADVASEFESARLYLARWARVVAEEGEKARRDELASKARIQRRKSATSLSASQSGSLSPVEDLESSLGVFSMLPKSYSKRPIPNPTRTPQHPITAREWESLSAQGRDELYVRREIFKRGFSDSSEPEEIKARKEGWEVLLGIIPWQIGGLGGGESGKEKRNKQREEARRAKRQVYAGLKGKWRKEAAREDEVNGGREDWREEWHRIDVDCRRTDRNQAIYAVPSSAAHKGDHEKEGGGANTSLRRGSLGADSQGEEEEGSAAALNPHIAALRTILMTYHTYSPELGYVQGMSDLLSPIYVVFDANEADAFWGLVGVMKMMESNFLRDQSGMKRKLSTLQQLISVMDPELYAHLERTDSLNLFFCFRWILINFKREFKFEQVIKLWEVLWTNFYSDQFVLFVALAILQSHRDVLIRYLTEFDEVLKYANDLSGTIDLDTTLAQAEVLFLSFRSLVEDLDKENAQLDEKNKEGLRHRRINSDVTGSSSSGKKGKGKEKSDEDAMEEESKKKDRKFISDDLRGLLIGWRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HTX9</accession>
    <name>A0A1B9HTX9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_07113</name>
        <name evidence="6" type="ORF">I206_106311</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894015">
        <property type="protein sequence ID" value="OCF46726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007945.1">
        <property type="nucleotide sequence ID" value="XM_019158807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HTX9"/>
    <dbReference type="STRING" id="1296096.A0A1B9HTX9"/>
    <dbReference type="GeneID" id="30175482"/>
    <dbReference type="KEGG" id="kpin:30175482"/>
    <dbReference type="OrthoDB" id="2561680at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="10"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="53"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="619"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="636"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="652"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF46726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC72349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="665" mass="73746" checksum="22C438064296E9C5" modified="2016-11-02" version="1">MSSFLKPSKTCDQCRVRKIKCVGSDRERSSSCEGCDKLSVDCTYDYIRKKPGRKNSLGLNVKRRQSSESQSIQNEASIQSGAQRPRIYSQLPVQHNSNVSRAWLTLNDRTSIAAPHLPQAASPATVLLTPPTQSLMAATPDSPFKTSMDPSKSWLDSLLDGTGFPPVSTSTELVVNSGDNMPHNTDLNMSFASDQAQLLSLESLVGMNAFSNSPGKVETMSNLGGRREPQLEDLTNWTNITHFIALFLKYLYPILPLVHRPTFSEYLATRRDLIDTDFRALLLSIVAYVISQLPTSRLINDQFDIEGLKRLQRRCHRTCKALQRTYYGPTNSTQISTIIFDTFYLLSIGLGHTAGARLGQAIQLAYSMGMHSDAKTEALGLDPIEIQLRRRVFWQLYAADKTRAISGLPMMINDFQGVCSLPEPVDDEFITSQGSFAQPASRPSPIAGFVACSKLFRIMSECFFHHRCIISNMRTVDTAWTVTVEDRLHQLLQDFLDVTQDHSVHGNDTIKHMLAVQRANILITAAICKFALSDLRIALQVDKDQMGKEREVIAREIHSSLMNIPVEDLASNGESVRSKIFHIVCALCDQNPASAVDQGLIWDWYNMFSAISFVQMPPPPPEAALDSRANSPPPASMQQQQQSQYPLPGPLTGSSSGITMNPGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HUP1</accession>
    <name>A0A1B9HUP1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_06761</name>
        <name evidence="4" type="ORF">I206_102145</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Berlin A.M."/>
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                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
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                <person name="Imamovic A."/>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
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                <person name="Birren B."/>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
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                <person name="Sun S."/>
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        <property type="entry name" value="CuRO_2_Fet3p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13899">
        <property type="entry name" value="CuRO_3_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000024">
        <property type="entry name" value="FET5p Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044130">
        <property type="entry name" value="CuRO_2_Fet3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF361">
        <property type="entry name" value="IRON TRANSPORT MULTICOPPER OXIDASE FET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628186" evidence="9">
        <location>
            <begin position="21"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="582"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="12">
        <location>
            <begin position="29"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="160"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="11">
        <location>
            <begin position="392"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCF46997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WWC68213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="640" mass="71464" checksum="2D11B1A1750EA537" modified="2016-11-02" version="1">MTRFANLLSAVTLAGGLARAATIEHWWNITYTTANPDGLQERRVIGVNNSWPPPMLTATQGDVLIVHATNGLGDDKVGTALHTHGMFFNGSNWADGAVGTNQCPIPNGYTMDYLINTTYQTGTYWIHGHHEGQNTDGLRAPFVISPQNQTGRSDNVTWDEEYTLVVSDWYHDEYPDLIKDEFLTWTNPTGAEPVPKSAVCYVAKNGSYLHSNEDLSKGVGVSDDAEIAFEAGKTYKIRIVNTGTLGMFWIKMDQHQMKIIEMDGIEMEPYPIDVLTVSVAQRYSILVEALNTTGTNYAMMIMQDTDMYDLVPDDLQLNNTIQITYDSNASKAQAVETGIDDITTFNDTQLHPVLKNELLQPNVKFELNAYFDTYDDGTNRASFNNITYQMPMVPSMLTAASMGQDAYNTAVYGAQTNAFVYKQGDIVELTVFNWDAGFHPFHFHGHEFQIVHKSFDVTSDDRIINPLIDENQTNPARRDTIVIPPTGSVTLRFRADNPGAWMFHCHIDWHLSSGLAAIFIESLDVFQSTNETINEVPQQIYDQCKFWNTPTSGNIVGKFSTTDFKGQPYGPFPVKMGWTSKAIGALAGCIITVLLGISTIIWYASGELNENELEEEVKFKLASKEKKIPIWKRVLPNKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HV59</accession>
    <name>A0A1B9HV59_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_06927</name>
        <name evidence="3" type="ORF">I206_101981</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700117">
        <property type="protein sequence ID" value="OCF47149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC68062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008368.1">
        <property type="nucleotide sequence ID" value="XM_019158622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HV59"/>
    <dbReference type="GeneID" id="30175296"/>
    <dbReference type="KEGG" id="kpin:30175296"/>
    <dbReference type="OrthoDB" id="2564452at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="375"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="464"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF47149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC68062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="495" mass="53632" checksum="CFC6FEBDB5809BA3" modified="2016-11-02" version="1">MNQSQHCLFSFQQQSATALSNLSIPHFPAIPISPPAPHRKAPRPPVYSPRRIRPRHINMKEPAQLGLFTVLETEEDSYDQCFTPCSSESDMESSPSLSGGKNMYNLPSAVASSEIFPSPSCSPSPLSSSSSCAHRSSPINVPRDINEDIEMDEKLSRLSWSSKGSLASNATAFLTEGETESEFLLATPSMENDDPFGWSTTITFPDEFEPDVEMAEDTIGGNLYTPSHLTKKPTLAESIRSSVKRPPPLKLSTGFLTPIATPTSAKLFSAISNASTAESDLILTPQTATSPSTDLLLPSLPIISSIEWESRRYASPIPGFISPSTPTRSRRTSTKVLKRKSPDDPIDLAMALEDLLNSCGENLDNPSSCSESEFSGPASVTASSSTSSDSELEFESKPLRFPLPPNRLPLKTPSPIKKSFRPLTPYAPKKDRRSFSRIADCGVSPTSFKGDHSFLISLSMGKESVGSSSVSSCGSKSSKKSLPSRRGLPTEWIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HVU8</accession>
    <name>A0A1B9HVU8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_06279</name>
        <name evidence="3" type="ORF">I206_101751</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
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                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
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                <person name="Roberts A."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Imamovic A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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            <dbReference type="EMBL" id="OCF47401.1"/>
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    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    <sequence length="223" mass="24564" checksum="F93039A6FF130D58" modified="2016-11-02" version="1">MANRIPRLLKLHTLPGQLIFLTTISLGVGWGITQLKENEPIHSNLNLNKNKKMQKGDLVDVIESASGGGEGLNSNQINRKGGINLSDALTAERTASIWWNYARDNSIITGRLCSNEKESTILVPIDKAILNLGRKPHQYPGLTYKGTFSTSKINTERFLQAHIIDGKVKDGKIKTLLDGFIVELIPDKSQKGGYKIQPGDIEVLGSKETSNGKILYISKVLPY</sequence>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">CBS 10737</strain>
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    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
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                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
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                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
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                <person name="Zeng Q."/>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
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                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="Heitman J."/>
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                <person name="Litvintseva A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="Zeng Q."/>
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                <person name="Litvintseva A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
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                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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                <person name="David-Palma M."/>
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                <person name="Mohammad A.W."/>
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                <person name="Yurkov A.M."/>
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                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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                <person name="Litvintseva A."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
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                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Sykes S."/>
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            <authorList>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">CBS 10737</strain>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Murphy C."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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    </reference>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
        </source>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
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                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">CBS 10737</strain>
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    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
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                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
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            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HYX4</accession>
    <name>A0A1B9HYX4_9TREE</name>
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        <submittedName>
            <fullName evidence="2">Phosphatase</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">I206_05268</name>
        <name evidence="3" type="ORF">I206_107186</name>
    </gene>
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        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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            <taxon>Cryptococcaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="FRUCTOSE-1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
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        <location>
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            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="EMBL" id="OCF48489.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC73220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="323" mass="34931" checksum="41A45632914B02E2" modified="2016-11-02" version="1">MSDQRYKQASIFTADGVLFDMDGTLTDSIAAVEAAWTAKAEELGLEPEAVIKATHGRRASDNLTELVPGLRKEHVERVEQEVEKFEKSILTFADTPPYSRRGSLSSARSRNSSSSSRRSSSMTPLTPVSNTPDISKHPLFQMSTADTLNMTSMKLSSTTISEVAVVDETPFDEDEAEDIIDMSVKILPGVRKMINSLPEGKYAVATSGAKTYCHGCLNRTGIIIPKVCVTADDSRLLRGKPFPDPFLLAASDLGIAPTRAVVFEDSPSGIKAGVASGATVIAVCTSHTRDKIENLGAHYIVDTMDQIKVDHLEDGQLQFTVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HZ24</accession>
    <name>A0A1B9HZ24_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_05289</name>
        <name evidence="13" type="ORF">I206_107165</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2"/>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC73199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009729.1">
        <property type="nucleotide sequence ID" value="XM_019157011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HZ24"/>
    <dbReference type="STRING" id="1296096.A0A1B9HZ24"/>
    <dbReference type="GeneID" id="30173658"/>
    <dbReference type="KEGG" id="kpin:30173658"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000001">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF10">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="11">
        <location>
            <begin position="29"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="379"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="391"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="403"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCF48510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC73199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="584" mass="65288" checksum="A687730C79FF05D6" modified="2016-11-02" version="1">MEPILGESKRRVCYFFDSDIGNYHYGPGHPMKPTRIRMCHSLVMNYGLYKKMEIFRAKPATKREMSQFHTDEYVDFLHRINPDNAQQFAKEQVKYNVGDDCPIFDGLFEYCSISAGGSMEGAARLSRDKCDIAVNWAGGLHHAKKAEASGFCYVNDIVLGILELLRYHQRVLYIDIDVHHGDGVEEAFYTTDRVMTCSFHKYGEFFPGTGEVRDNGIGKGKGYAVNVPLRDGISDENYQSIFQPVIKRVIEWYQPGAIVLQCGSDSLSGDRLGSFNLSMRGHAACVQFVKSFHLPLLLLGGGGYTVKSVSRTWAYETGLAAGVELQKNIPNNEYWEYYGPTYELDVRSSNMTDHNTPEYLQKVTESVFEFLRDKNAAPSVPLQDVPKLNHDDEDENELEDIEDKDKRRPQRLWDKEKQNENSLSDSEDEGTGGRKHRQNHKISSSSSTSLLIENGKRKRSKSKSKSPTTNIDSIQPISSTSRVSNVNGDETEGINVEQWAESIQPTNESVLPTTNINLNSNVNGDGDVEMIDSTAPTTITETGITSQTPIENVNQDPIEQVQERTVDEGVLSGTTAGDLIAEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HZF7</accession>
    <name>A0A1B9HZF7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_05420</name>
        <name evidence="2" type="ORF">I206_107037</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC73072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009859.1">
        <property type="nucleotide sequence ID" value="XM_019157141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HZF7"/>
    <dbReference type="GeneID" id="30173789"/>
    <dbReference type="KEGG" id="kpin:30173789"/>
    <dbReference type="OrthoDB" id="2564958at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCF48640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC73072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="108" mass="12163" checksum="28201894E22511E9" modified="2016-11-02" version="1">MSLSRSTISSDINHLLSISNEIIYSILNPSISSSTLKSNEKPIEILNEYSSFKANNEDSQKLSKAYIDQMKFSKNLQIGGEVENLGERIDELRDRGQNLQEVLSEVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I0V2</accession>
    <name>A0A1B9I0V2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Asl1-like glycosyl hydrolase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_04864</name>
        <name evidence="5" type="ORF">I206_106041</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010395.1">
        <property type="nucleotide sequence ID" value="XM_019156593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I0V2"/>
    <dbReference type="STRING" id="1296096.A0A1B9I0V2"/>
    <dbReference type="GeneID" id="30173233"/>
    <dbReference type="KEGG" id="kpin:30173233"/>
    <dbReference type="OrthoDB" id="5959761at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF14">
        <property type="entry name" value="ASL1-LIKE GLYCOSYL HYDROLASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628275" description="Asl1-like glycosyl hydrolase catalytic domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="3">
        <location>
            <begin position="196"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF49176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC72081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="414" mass="44618" checksum="F48FA584F06B5692" modified="2016-11-02" version="1">MLQFTLITLLPFLLPISAAPARRNCAVKSSSSSSSSEKSNNSEAIAAFAQHVNNTVLIPTGTGAVIPSIAITSLSVTNKNIAAFDKGRWNGWGGPKSSNVPTFLSSLSQPLVNTQKTSLPAYTQAPATSPSSVTQPPASSPSTIIPSASLTSKFETSQTISSAAPVTTASGSGTAGSGSGEKVGLGLDDTAYSKLTNIQNLGWYWNWGTEPFQGMQSEFVACVWGKEKAESFTGVTDDIKYIMSFNEPDQGANVGGCDIKDTALAATLHQQWTAKVSGDVKIGSPAVARGGVESWFTPWVTACAGNCKYDFIPIHFYGTEIEDLFKYIKEFPRQGKPIWVTEFDCQDFTTGEICDNEKQKDFMEKAINWFKNEGSSYVERWSWFGSLPKFSELTYGLENVDGTLNSLGEHYLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I158</accession>
    <name>A0A1B9I158_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">General stress protein FMN-binding split barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_04942</name>
        <name evidence="3" type="ORF">I206_106118</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010473.1">
        <property type="nucleotide sequence ID" value="XM_019156671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I158"/>
    <dbReference type="STRING" id="1296096.A0A1B9I158"/>
    <dbReference type="GeneID" id="30173311"/>
    <dbReference type="KEGG" id="kpin:30173311"/>
    <dbReference type="OrthoDB" id="434253at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052917">
        <property type="entry name" value="Stress-Dev_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038725">
        <property type="entry name" value="YdaG_split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34818">
        <property type="entry name" value="PROTEIN BLI-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34818:SF1">
        <property type="entry name" value="PROTEIN BLI-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16242">
        <property type="entry name" value="Pyrid_ox_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="General stress protein FMN-binding split barrel" evidence="1">
        <location>
            <begin position="19"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF49254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC72158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="198" mass="21656" checksum="FBFEAB01418F2660" modified="2016-11-02" version="1">MSDQYSASASTSPSLTEKLTTLRAFFKAQKAVILTTRAEDGSLHARVMAVAEITPDWKFRFIYDKESHKDNEVENDSHVNIAVDGTQNNTGWASIAGKAKRVEDNAVVEKLWNPTIKAWFSDKGDGVHDGTPSDPRVVVFEVKVDEIRHFHQEKTGLGTLVDVVSSTISGSTATPGSIRTITGEEIAGAWAKNELKEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I1D4</accession>
    <name>A0A1B9I1D4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_05045</name>
        <name evidence="3" type="ORF">I206_106219</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010571.1">
        <property type="nucleotide sequence ID" value="XM_019156769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I1D4"/>
    <dbReference type="GeneID" id="30173414"/>
    <dbReference type="KEGG" id="kpin:30173414"/>
    <dbReference type="OrthoDB" id="2595549at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="127"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF49352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC72257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="609" mass="67456" checksum="7E94D66B0530CF5C" modified="2016-11-02" version="1">MSTTAIRMTTHAPSPSYVPRSTLGSRPNSPALPPKPQAATYSNHGRSSSTSRLDTSLKASTMSPSIGGGAAPTPRLGPIERSVSGLRNEVKDESRKEQKSEAARAILKMLSSLPAPLPEKLPPTFLPTPSTSPISLAGSPTRTFTDYARSSLKRNKRKRATDSSSSSSDSSTDIPSSGFTGNHANGNIGLGLGLGLSMSSPEQARKKPRLENDKPDTVRRSSAINQNGRSLTPAGSGQSSSIPTTSSKKPGTSNLRNEVTEEESKENWSKEKWRSTAIMYRERALLMKRHGDAYQRVSTAQPKYVSQLPKDPLKGCLSLTDAVLLWLYSYFCDEQDRGRVRATPYNESAPLREYVKKAWENEMRNALEEEEDRREMAQGMVGLMYLIEAVIGYHLTSEQFIHLNQRGKELQNSIQINVQHQQQQQQTSSSYKSSNSSPPNNSNFVQIQNNISPSSNNNQHSPESNISCNSSSSSSSTINTNYNLPPDLLPLINSSTNSSFKSQQNLLNSRNYLTILILSKRFPKTFNFALNSSSSFNNNNKLKIINLNDNNKINNNNLNLNIDKNPENFNWPIELGMSEPILNIVAFGRCLIEEMANHFKKDWIRIVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I1H6</accession>
    <name>A0A1B9I1H6_9TREE</name>
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        <recommendedName>
            <fullName evidence="3">Transcription initiation factor IIF subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">TFIIF medium subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">TFIIF-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I206_05089</name>
        <name evidence="14" type="ORF">I206_106263</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIF beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010615.1">
        <property type="nucleotide sequence ID" value="XM_019156813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I1H6"/>
    <dbReference type="STRING" id="1296096.A0A1B9I1H6"/>
    <dbReference type="GeneID" id="30173458"/>
    <dbReference type="KEGG" id="kpin:30173458"/>
    <dbReference type="OrthoDB" id="449280at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07980">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000035">
        <property type="entry name" value="General transcription factor IIF subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003196">
        <property type="entry name" value="TFIIF_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040450">
        <property type="entry name" value="TFIIF_beta_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040504">
        <property type="entry name" value="TFIIF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02270">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17683">
        <property type="entry name" value="TFIIF_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIF beta subunit N-terminal" evidence="12">
        <location>
            <begin position="50"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIF beta subunit HTH" evidence="11">
        <location>
            <begin position="271"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="335"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00081473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCF49396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WWC72301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="391" mass="44958" checksum="C56F8E7AA684D043" modified="2016-11-02" version="1">MSQDTKPNIQISSFDSPSSSQAGPSSSTEQYFPYVYNEDEELQISERKNNSSVWALKIPRFLLERWEMVEEKGVELGSLIVDNSTTPAKITLRLANQDEKPSIDESKSDEALKSKSQYDISGIPDEYTVNVPEERARNLYVFSEKKKVYGKNTTSVAISEGDLESEAANDGSGNGSKVGGKRKREKAFPKLIAKVDHECQVTPLHTQKYLKILEQRRLESEQSKRPVMRMDDTGISQAEQNQLASGYRNAISTFGSKMITSVKVNNGERHARLERHELTDRIFQLFKEKPYWGIPALKMTLKQPDGWLREVLRDVAEQIKEGKYVNMWQLKKSWRSNNEQDKDKDDTKIEIDIKPDLKENDQFENDNNHEEEEAEDDDDEDEEDDFEEVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I1K7</accession>
    <name>A0A1B9I1K7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">transketolase</fullName>
            <ecNumber evidence="4">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I206_05113</name>
        <name evidence="17" type="ORF">I206_106287</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="11">Binds 1 thiamine pyrophosphate per subunit. During the reaction, the substrate forms a covalent intermediate with the cofactor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010639.1">
        <property type="nucleotide sequence ID" value="XM_019156837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I1K7"/>
    <dbReference type="STRING" id="1296096.A0A1B9I1K7"/>
    <dbReference type="GeneID" id="30173482"/>
    <dbReference type="KEGG" id="kpin:30173482"/>
    <dbReference type="OrthoDB" id="10267175at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07033">
        <property type="entry name" value="TPP_PYR_DXS_TK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000004">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000012">
        <property type="entry name" value="Transketolase, variant 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055152">
        <property type="entry name" value="Transketolase-like_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005478">
        <property type="entry name" value="Transketolase_bac-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049557">
        <property type="entry name" value="Transketolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00232">
        <property type="entry name" value="tktlase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="TRANSKETOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522:SF6">
        <property type="entry name" value="TRANSKETOLASE-LIKE PYRIMIDINE-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22613">
        <property type="entry name" value="Transketolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="15">
        <location>
            <begin position="385"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="447"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="145"/>
            <end position="147"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="499"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="507"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="511"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="558"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="13">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="13">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCF49420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="WWC72325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="723" mass="79336" checksum="364EBCE43234617E" modified="2016-11-02" version="1">MSPIATQAINSSHGSELSKDPHVLANVSSPDTEKLVINTIRCLGADLCQQYKGGHPGTVMGAAAIATALWKYSMRYNPANPDWVNRDRFVLSAGHACLLQYILLHLSGYSTWTLDQIKKYHAPTMDGIAAGHPEIEFPGVELTTGLLGQGIANAVGLAIANKNMAATYNKDGFPIVDNKVWCFTGDGCLQEGIGQEAISMAGHWGLDNLILVYDNNSVTVDGSIDICFTDDTSAKLKSMGWYVLEVDDGSNDLAAIVEVFDQARSSVGKPTFINIKTVIGIGSANQGSGKVHGAALGEDDVRNVKSALGFNPDEKFFVPQSVYDYFKETKIRGQQYEEQWNQLVENYRRSYPKESAELQRRLKGELIEGWEGKLPAKGSLPKDPKATRQTSGMFLKSIIPEDNSFLVGSADLCESTFVNWDNMVEFQNPKSGYGDYSGRQVRYGIREHAMVGVANGVAAWHKGSFVPIMSSYFIFWLYAAPSLRMAALMKLRFIAIATHDSIGVGEDGPTHQPVAFPTFLRALPNFNYVRPADAEEVAGAWILALKDEDSPSLFSLTRQPVPLLEGTDRKKVQYGAYVVHGDAGEIPDLTLIATGSEVARAIDTAKILKDYKVRVVSMPHMGRFDKQPAEYRRSIIPSTKCLVVAIEPYCSFGWAKYAHAGAHMTGFGHSAPYSVLFEHFGFGPQNLADKISTWAQTRKRSQGWDLPGVGEFEELLLHQNTAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I214</accession>
    <name>A0A1B9I214_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein translocase SEC61 complex gamma subunit, archaeal and eukaryotic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_04104</name>
        <name evidence="12" type="ORF">I206_104318</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010801.1">
        <property type="nucleotide sequence ID" value="XM_019155843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I214"/>
    <dbReference type="STRING" id="1296096.A0A1B9I214"/>
    <dbReference type="GeneID" id="30172473"/>
    <dbReference type="KEGG" id="kpin:30172473"/>
    <dbReference type="OrthoDB" id="2401875at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.820">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023391">
        <property type="entry name" value="Prot_translocase_SecE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008158">
        <property type="entry name" value="Translocase_Sec61-g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00327">
        <property type="entry name" value="secE_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12309">
        <property type="entry name" value="SEC61 GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103456">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01067">
        <property type="entry name" value="SECE_SEC61G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OCF49582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC70368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="70" mass="7861" checksum="F6661C95605E0770" modified="2016-11-02" version="1">MAEKITEFAEIPQQFIKEGTQFVNRCTKPSKEEYIQLCRAIAVGFVVMGFIGYFVKLIHIPINNILVGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I225</accession>
    <name>A0A1B9I225_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cyclophilin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_04111</name>
        <name evidence="5" type="ORF">I206_104312</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010808.1">
        <property type="nucleotide sequence ID" value="XM_019155850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I225"/>
    <dbReference type="STRING" id="1296096.A0A1B9I225"/>
    <dbReference type="GeneID" id="30172480"/>
    <dbReference type="KEGG" id="kpin:30172480"/>
    <dbReference type="OrthoDB" id="407442at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48037">
        <property type="entry name" value="ATPASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48037:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="17"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="124"/>
            <end position="144"/>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I291</accession>
    <name>A0A1B9I291_9TREE</name>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Nusbaum C."/>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
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                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
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                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
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                <person name="Goldberg J."/>
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                <person name="Imamovic A."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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    </reference>
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            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Pearson M."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I2E6</accession>
    <name>A0A1B9I2E6_9TREE</name>
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        <recommendedName>
            <fullName evidence="10">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="11" type="ORF">I206_04240</name>
        <name evidence="12" type="ORF">I206_104185</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010935.1">
        <property type="nucleotide sequence ID" value="XM_019155977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I2E6"/>
    <dbReference type="STRING" id="1296096.A0A1B9I2E6"/>
    <dbReference type="GeneID" id="30172609"/>
    <dbReference type="KEGG" id="kpin:30172609"/>
    <dbReference type="OrthoDB" id="7608935at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051644">
        <property type="entry name" value="TRAMP_AT-DNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543:SF1">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="10">
        <location>
            <begin position="215"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="10">
        <location>
            <begin position="253"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="10">
        <location>
            <begin position="334"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="608"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="452"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="487"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="570"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="651"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="735"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="746"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
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    </evidence>
    <evidence type="ECO:0000256" key="9">
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="OCF49716.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC70235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I2G8</accession>
    <name>A0A1B9I2G8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_04163</name>
        <name evidence="4" type="ORF">I206_104261</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
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                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Roberts A."/>
                <person name="Saif S."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Berlin A.M."/>
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                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
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                <person name="Imamovic A."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
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                <person name="Sun S."/>
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                <person name="Nusbaum C."/>
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        </citation>
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            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Murphy C."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
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        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
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    <name>A0A1B9I2Z3_9TREE</name>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
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    </reference>
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            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF49909.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC70042.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="396" mass="45786" checksum="4867A2D2FCDB6826" modified="2016-11-02" version="1">MTTHQNGEGSRNRDMEISDSRGKVIKAPKEDIDAIQTSLTARRRMSLKSLLGNYKSQNAALKGENHLNPDDDGLIEDEEEIDSNEQDEYFDQTIRIDTIDLEAYQKSKGDPIDILRLDQEGIRKDIKNVEDELNIDLQKEYVWDVLFENQRGIYIFGKGYFSAGGLLPADPSAFTRPSDDMPSASSLGKKRSKSSAVNDTDPQPSSSGDEQSKKMDKKGNQRSNKTSYTLETFQPPLPDWEYVTPWMINMRTGTDELGWRYNAWFKKKGWSSHSGVLGWGGWVRRREWIRLRGVDIRKDHSQIKINEEERDKLERKGKTLEDILIHDDIEENVQDILVCMGKINLDRQRLELWERWLAHLKQNDDNDGNRKRLIDICEDEKAVSTVHLFLIACFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1B9I3A7_9TREE</name>
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        <recommendedName>
            <fullName evidence="4">6-phosphogluconate dehydrogenase NADP-binding domain-containing protein</fullName>
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        <name evidence="6" type="ORF">I206_103965</name>
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        <dbReference type="NCBI Taxonomy" id="1296096"/>
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    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family. NP60 subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="OCF49931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC70021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019156192.1"/>
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        <property type="component" value="Chromosome 5"/>
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        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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    </dbReference>
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        <property type="entry name" value="6PGDH_NADP-bd"/>
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        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE NADP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="8"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF49931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC70021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="329" mass="36637" checksum="87F8075818CB4240" modified="2016-11-02" version="1">MSSIKDQRIGYVGLGNMGSHIATNLSKYISENDLPPLTIWNRSKEKYNFLKNNKKLNQNKIIYSNELIEVIKNSNIIFTMLINDNVSENIFEQFFNYLKENQKNEKQNLIFIDQSSLKSITSEKLFKKFKSINSFYLSCPVFGRPPMAESSKLLIISSGPFEIKEKIKHLLNPIIGNRLIDVGEDVKKATAIKSMGNMVLLGWIQLLSESYALGDSIGIDPSIFDEFLQKFIPAPPLLAYSNTISKGLFPSGGGFSIDGGLKDARNMISLGSDLGHPVSLPTIERAKDNMERSKELGGKDQDWSSLAAAVREQAGLEPYREGTNGGKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I3E8</accession>
    <name>A0A1B9I3E8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ER lumen protein-retaining receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_04512</name>
        <name evidence="13" type="ORF">I206_103915</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ERD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC69971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019156242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I3E8"/>
    <dbReference type="STRING" id="1296096.A0A1B9I3E8"/>
    <dbReference type="GeneID" id="30172881"/>
    <dbReference type="KEGG" id="kpin:30172881"/>
    <dbReference type="OrthoDB" id="7694678at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046923">
        <property type="term" value="F:ER retention sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
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        <property type="entry name" value="ER_LUMEN_RECEPTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10 11 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCF49981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC69971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="150" mass="17196" checksum="78454EDF6F4F98FC" modified="2016-11-02" version="1">MKLFFIGSTGYTLFLMKVKFRPTHDASLDTFKLTYLLPPVAILALLFNYSYSPFELTWAFSIWLESVAILPQLFMLQRTGEAETITTHYLAALGLYRGLYIPNWMYRYFTEGAFDPIAVVAGLIQTGIYADFGYIYVTKVLRGQKFELPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I3L0</accession>
    <name>A0A1B9I3L0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_03384</name>
        <name evidence="5" type="ORF">I206_105713</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
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                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
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            <strain evidence="4">CBS 10737</strain>
        </source>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
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            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Abouelleil A."/>
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                <person name="Berlin A.M."/>
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                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
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                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">CBS 10737</strain>
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    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
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                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
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                <person name="Griggs A."/>
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                <person name="Hansen M."/>
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                <person name="Imamovic A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
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        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
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        <subcellularLocation>
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        </subcellularLocation>
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        <text evidence="4">Belongs to the ELP5 family.</text>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
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                <person name="Young S.K."/>
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                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
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    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS27 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:vacuolar transport"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="UIM_dom"/>
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    </dbReference>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 8" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="31"/>
            <end position="153"/>
        </location>
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            <end position="232"/>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I4E5</accession>
    <name>A0A1B9I4E5_9TREE</name>
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            <fullName evidence="5">Beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase</fullName>
        </recommendedName>
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        <name evidence="3" type="ORF">I206_105385</name>
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        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894010">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC71429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019155452.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="kpin:30172077"/>
    <dbReference type="OrthoDB" id="6474464at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I504</accession>
    <name>A0A1B9I504_9TREE</name>
    <protein>
        <submittedName>
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    </gene>
    <organism evidence="5">
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    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <location>
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            <end position="684"/>
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    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="4">
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        <source>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
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            <dbReference type="SAM" id="SignalP"/>
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        </source>
    </evidence>
    <sequence length="684" mass="75738" checksum="BC60DF2C02EE8B9F" modified="2016-11-02" version="1">MRSTVILALALGVLSNAQQVSLGPETYTAAGEFPTSLFSTYWNEPTQTASQVQPVITDSVLNITYPLNLTDPDTISNNDTKDPLYYPRTNLTGSAAQTLYQNVTAKIEEIIQNGQGSNCTRCIEAMTVAGNLAKQAPKLVPQLLVSLCQKYKFASVDGCQVYSAQAQVPFYAQVLAYANLSGSDGQYLCQNFITVSKCPRPPLPQFDSSEFWTKPKPSNASAPEPKGTNRVKVLHMSDFHVDPRYATGSEANCTSGLCCRRGNPISSLQSNFTASVPAPRFGYFACDTPWALGAAAVEAIPVLTGTDGEDKLNMTIFTGDLVSHDPYNQLSRDYILYTETALYDLWKRTLNPSSPLFAAIGNHDQYQQAFDSPDTLPGNLTKQFSWNYDHLSSLWKNNDWIDDEAVKEAKAHYGAYSVQHASNLKIITINTDLWYRSNIFAFINTTQSDNFGFLKFLAQELQEAEDQGSRAYIVGHVLSGWDGTNPIIGPTDAFYQIVDRYSHVIAGLFWGHTHEDQNMIYYSNNATDISTETAQNVGWIGPSITPLTDINSGFRLYEVDADTWDILDAHTWYSNVSTYGELDNQLEVGPSYQYEYSTREAYGQNFDWPENAPLNATWWHKVTEQMSNDAGALVNLYNAHQGKMSVRSPNCTSTDCIEAKICYIRSGSAPLGLNNCKPGFGSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I511</accession>
    <name>A0A1B9I511_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Allantoate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_03940</name>
        <name evidence="10" type="ORF">I206_105150</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011834.1">
        <property type="nucleotide sequence ID" value="XM_019155680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I511"/>
    <dbReference type="GeneID" id="30172309"/>
    <dbReference type="KEGG" id="kpin:30172309"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF81">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="83"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCF50615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC71197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="532" mass="59563" checksum="D77C249A3F0B7F4E" modified="2016-11-02" version="1">MPQLMEEKPDIVSADGTVPIEMNDLESRGTGEKVQGLERVESARSNVMDELAKGESVSYDELPIIEVTPEENRRVVRKLDLVLLPLTMVAYTLQYIDRSAMSYAAVFTFRKDLKLTPSDYSWLGSVFFFGYLFFEFPGSYLLQRLPLNKTMGTCILIWGGLLMCMAAPTHFAPAAVIRTLLGCAEALVTPGFVLLISRFYKREEQPLRVGLWYCCNGLGSFIGALVSYGMGHVHVASVRPWAWIFIVNGGVTVLFSLIFLWLCPENPQTCRFLTPHEKRIALERVRGNKSSLGNKEVKWYQVKEALFPWIDPQGWAYALIVFTISVPNGGIGNFLHLILQSYGYTAFQTILMGLPQAAMQVVFPLSGAYIARKVPQARLWVLMAYMLPSLVGVIIQYKTRNSGALLFGYYILGSYVASLGICFAAPGANVAGYTKKVVVGAMVFIAYATGNIVGPHFFISTEVPAYKSGMFACIICFTITIPMTFALRLYYVRENRRRDRLAEERGEGAYDETRGDFSDQTDLENMSFRYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I587</accession>
    <name>A0A1B9I587_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_02745</name>
        <name evidence="4" type="ORF">I206_102398</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF50690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011909.1">
        <property type="nucleotide sequence ID" value="XM_019154506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I587"/>
    <dbReference type="STRING" id="1296096.A0A1B9I587"/>
    <dbReference type="GeneID" id="30171114"/>
    <dbReference type="KEGG" id="kpin:30171114"/>
    <dbReference type="OrthoDB" id="2505754at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="232"/>
            <end position="279"/>
        </location>
    </feature>
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        </location>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF50690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC68470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="615" mass="66602" checksum="E2ACD909355BB114" modified="2016-11-02" version="1">MSSPNPADHPLPISPDPSISPIATIPLALPLDTSDSTTVTSTAEDTEALITSLKASLTTAQNTISSQTTKLSSLSDVETALTQLKDQYAFLSAAKEAVESQLQEEIRKREVAEENVEMLRGQVEQARRGVMTLQKQEADRKRMSTISSIGGGLGLGIQGQLGEEEILSNVEGSSSSRESKLVKRQSIMRSHRRQSSQSEPSDILERAANLTSPNLQNQRESTLRPSGQGLRELRLSHNSPSNSITAITPSPNFALSGNPNSSDYFDESTTSEPPSSIQSKNIELPSKKEIEAIEEANRLKGDLAILQNKLEESEEARIASEVCLKALREFMANNSVSGEGDVAESGEMSGSTADLLKGIRLPPLPTDRDADEEQRNKEAVAEAEKAKQAAVAGGWGFKLWNAKSPATNPISPGKEHLSPQHKTLSPSNRSRAGSTATVSPLPTPLSEDLPTPTTGLITSTSSQAPLSSFVSNWTKGVSIPSTNSPSVPSTERPNSSRKISVTNFFSRGKKDVQTEPLHEEKELPTPPNEIENSGKEELEPSPEITTRELVFNENDKRVSRGTIGTTMTELEEELGTPQNSLKGVTESEYENDQEKTKEEGELQQEGKERMDEIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I5I8</accession>
    <name>A0A1B9I5I8_9TREE</name>
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        <submittedName>
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        <name evidence="3" type="ORF">I206_102493</name>
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        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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            <taxon>Cryptococcaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF50788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC68564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="361" mass="40530" checksum="02005614E36CEDC3" modified="2016-11-02" version="1">MLRTHALSNPSQQDVFHTGPPPLRPSTPPPPEPSLGPPPSRIQQPIQITRGITSKDYYDDAEDMLRSSFSNPLDYTSDRLEFFPPIRVPDALTIADAYANLPIGPYGGIRARAVEAERFPYLTVSLDQESDFDPQVDLRFKKGVRIDKTHWPHLYGAFRNYENALADSRFLIRSDSETNQQGILAMLEGDIINFLFSTKNDQPIFFDYLPRWLRNMYWIHEHKSNFMSRDSLVNLVGSAARSRKGILEAAGIPFANDPIYNRFTASDSRAGRGTKQVTLPFAGSIADHVIGELCNAEDGNAIKGIAIIYVEEKRLNPGTLRDLIYYLAHYNSATASLGHTRGNEENIPLSETFFPQEAGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I5Q1</accession>
    <name>A0A1B9I5Q1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Biotin-[acetyl-CoA-carboxylase] ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_02901</name>
        <name evidence="6" type="ORF">I206_102551</name>
    </gene>
    <organism evidence="5">
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        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the biotin--protein ligase family.</text>
    </comment>
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        <property type="protein sequence ID" value="OCF50844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC68621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019154660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I5Q1"/>
    <dbReference type="STRING" id="1296096.A0A1B9I5Q1"/>
    <dbReference type="GeneID" id="30171270"/>
    <dbReference type="KEGG" id="kpin:30171270"/>
    <dbReference type="OrthoDB" id="10250105at2759"/>
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        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin--[biotin carboxyl-carrier protein] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03144">
        <property type="entry name" value="GATase1_ScBLP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019197">
        <property type="entry name" value="Biotin-prot_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835">
        <property type="entry name" value="BIOTIN PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835:SF5">
        <property type="entry name" value="BIOTIN--PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09825">
        <property type="entry name" value="BPL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="4">
        <location>
            <begin position="462"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="740"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="746"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF50844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC68621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="782" mass="85073" checksum="011F308E55B0E65A" modified="2016-11-02" version="1">MPGPSASAHQVLVYSGPGVSPLSLSHTILTLSLLLLPHYTVQPVTPELLSSQPWEPSCALLVIPGGRDLPFVEELTIKRKVTKRIKEYVDEGGRYLGICAGAYFGTSQVKFDVGGSMEVTGNRDLAFFPGSSEGPTYPGFQYASENGSRAVSLFLEPSSSSSNSTHRSIDHVYYNGGGHFILPSPTPSNTQVLARYADVEGEPIAAVLTKNGKGKSVLCSLHPEYPLNDPPARLAINKLEHPPEVEEIEASDKARIEWVEELLLLLGLNPPSKARKTDHGTDKNQNEIDGEEDPKLLLHPTHPSPIFILSHPNLPELSTNAISKKELQGKMTQEEEGWKVLEDGNDQISFGPVEATSGSASTSENEIVQWLAKRRRDQPKLETPSIENLKIDDGDASPPIPQPPDFHSLPKTVLLPSSTIPYTPRWTPLFSFSSYWSELDLARKGAGKRSGVLRKGEEGEKSALGDLIIYGETVTSTQTMLDRNPLLLTHLTAPLAFLASFQLSGRGRGSNIWLSPPGCLQFSLLLDLPASLSSKMVFIQYIMALAVCEAVDEDGRLGVRIKWPNDIYAEVEGVGGTEIGSGKKGKAKLGGILVNTNFVGGKWRIVVGCGINVLNALPTTSLSQLHSLLAAKLSSTTSSRPLPAAPTMEGTFAKIMSSFDSKWEQFIDEKGFKGFMNEYHGRWLHSGQEVTLTTTEPHTPLRILSITQDHGLLRCVPIRTKSTSNSTGLTPLYNRIVDSSSEDRYTPSSAGPNRGNNTPEFVDLQPDGNSFDLMSGLIKRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I5X9</accession>
    <name>A0A1B9I5X9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine cleavage system P protein</fullName>
            <ecNumber evidence="7">1.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_02991</name>
        <name evidence="13" type="ORF">I206_102638</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 7">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GcvP family.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="7"/>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF50929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012148.1">
        <property type="nucleotide sequence ID" value="XM_019154745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I5X9"/>
    <dbReference type="STRING" id="1296096.A0A1B9I5X9"/>
    <dbReference type="GeneID" id="30171360"/>
    <dbReference type="KEGG" id="kpin:30171360"/>
    <dbReference type="OrthoDB" id="6537869at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016594">
        <property type="term" value="F:glycine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000097">
        <property type="entry name" value="Glycine cleavage system P protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000005">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000007">
        <property type="entry name" value="glycine dehydrogenase (Decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003437">
        <property type="entry name" value="GcvP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049316">
        <property type="entry name" value="GDC-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049315">
        <property type="entry name" value="GDC-P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00461">
        <property type="entry name" value="gcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773:SF1">
        <property type="entry name" value="GLYCINE DEHYDROGENASE (DECARBOXYLATING), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="GLYCINE DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21478">
        <property type="entry name" value="GcvP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="10">
        <location>
            <begin position="75"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="869"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="713"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR603437-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCF50929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC68704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1047" mass="113728" checksum="A0373A3AE8677428" modified="2016-11-02" version="1">MSIHLIKRSSRLTLLARSSSSSSRVFSSSAYLLRPHATSPTHSSTTAVQPHPNPPSTSFHPEKSSIFTPLDTFLRRHNGPRASDVESMLSTLGYKSMDAFIDDTIPQAIRVDKLSDKESSKTGIRPFSELELARRVEEVAGLNKPMKSYIGMGYHNAIVPPVIQRNVLENPAWYTAYTPYSPEQSQGRLESLINFQTVTTTLTGLPIANASLLDEATAAGEAMAMCLANVPKNKLAKGKKSFLVSPSVAPQTIAVLQTRASGFGIELIIAESNESFLKEIEQLGEDKLMGALVQYPDVNGAIGDWAEIAAKVKSLGAKTVVTTDLLALTMLKPPGEWGADIVCGNSQRFGVPVGYGGPHAAFFACTDDLKRKMPGRLVGLSKDSRGAPAYRLALQTREQHIRREKATSNVCTAQALLANMTAMYAVYHGPEGLRQIAGKVHSLTRILSESLAALGFAVVNKTFFDTLTIDVASAGFSATQVHAESVKSSINFRQIDDKTIGVTLDESVGPLDLTDIVNVFYRVKGQKEIQPGQLQELASKLELTSESVKSPISHHARTSDFMTQPVFNKHHSETHMLRYMMHLQEKDYSLVHGMIPLGSCTMKLNSTSSMVPLSRKEFGGIHPFAPKDQVKGYEVLIKELEEDLSLVTGYDATSVQPNSGASGEYAGLKVIQAYHESQGQGHRDVCLIPLSAHGTNPASAAMIGYKVVPIKALDDGSLDLKDLKEKAEKHKDNLAAFMVTYPSTFGVFEEGIEEANKIVHDNGGQVYVDGANCNSLVGLTSLGRVGGDVSHTNLHKTFSIPHGGGGPGVGPISVKSHLAPFLPTHPIITTGGSKAIPAVSAAPYGSASINTISWAYIKMLGGEGLTEVSKIALLNANYIAERLRPYYNVRFSNKNGRVAHECLVDLGEFEKSAGLKVSDFSKRLQDYSFHPPTAQWPISTCWLIEPTESESKAELDRFIDALISIRKEVDEITSGEQPKDNNVFKNAPHPLNILVDDKWDKPYSREKAVFPVPALRKTKFWPSVGRVDDAAGDLNLICECGSVEEYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I6I1</accession>
    <name>A0A1B9I6I1_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Charged multivesicular body protein 2A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_03193</name>
        <name evidence="3" type="ORF">I206_102840</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
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                <person name="Litvintseva A."/>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="David-Palma M."/>
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                <person name="Mohammad A.W."/>
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                <person name="Yurkov A.M."/>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
                <person name="Chen Y."/>
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                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="9">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="8">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8 9">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="9"/>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF51280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC69058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012499.1">
        <property type="nucleotide sequence ID" value="XM_019155096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I6W8"/>
    <dbReference type="STRING" id="1296096.A0A1B9I6W8"/>
    <dbReference type="GeneID" id="30171716"/>
    <dbReference type="KEGG" id="kpin:30171716"/>
    <dbReference type="OrthoDB" id="3341590at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015328">
        <property type="entry name" value="DUF1965"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF20">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09248">
        <property type="entry name" value="DUF1965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00766">
        <property type="entry name" value="CUDAOXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0186">Copper</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 9" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="DUF1965" evidence="11">
        <location>
            <begin position="273"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="10">
        <location>
            <begin position="354"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="428"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="7">
        <location>
            <position position="511"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="8">
        <location>
            <position position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCF51280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC69058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="827" mass="92727" checksum="6184E601A4A2C686" modified="2016-11-02" version="1">MDGGEDYLPLLKFTEDKECAGNSANASPSRSYSKIHTLLAVLAGVLLYPTVQYLLQPSLGLIDVPQVDGTSYSVPHCESTDLLPVRAPRKNVWKNLSVKEATEIRSWLWASERNLNLTKASLAVDSDNYIYLIEAFVPPKVATLAYLNGSSHAPDKYAHAIVNHGSSERIVDYLIGPLPISDDTQISPLTDIYHEPVIPYNAHGFGPNSTTLGNLIASTFAPLADLTMDLFGGVAKGLANDTLIGAGTAPLSYDGSWRRMWVGLKLNVPGHYLFPIDLYTYYEMSGTDSSRWHVIKMVYNGQVFSSPHEFRDAWESGKLKRSKKPLLDDTSGWATRTRMNRGGNRDLDDRAGPRSVSFDGLRFRVDREEQYITWMGFSFYLGFERDMGLNLWDINFKGERIIYEISPQEAMAQYSGSDPHQATTVFLDRAFGMGDSVKELMVGYDCPLEAVYLPATIHTAGGSTTRLNAICIFEKDSTKPLSRHTGWLKDEMGAIKGYELTVRSVSTVGNYDYIFDYTFQLDGTIEIRMSASGYLQGGVWDATQRPYGHQLRDTTMGSLHDHVINYKIDFDVAGTENSLMAAMLEMEEVEHPWADQDWGKTSTQQKVVRRYVASENDSRLEYPKNMEGMFVITNEDEQNSWGNSRGYAIHPGASNIHLTNLDCKRTQDNVNWAKHHLSVTRRHDNEPYSSSLWNIHLPGKPTVNFYKFFDGESLDQEDLVVWLNLGTHHIPRAEDSPQTLTNVATSSVLLTPYNFHDYDVSMDVLNAVLLNAPRPGEKWQIDENSVKQSHCLPRKVPDFAYTGLLSFKEDGSPASAADIVEQRKMGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I7B6</accession>
    <name>A0A1B9I7B6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Translation machinery-associated protein 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_02108</name>
        <name evidence="3" type="ORF">I206_104573</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMA16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012613.1">
        <property type="nucleotide sequence ID" value="XM_019153873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I7B6"/>
    <dbReference type="STRING" id="1296096.A0A1B9I7B6"/>
    <dbReference type="GeneID" id="30170477"/>
    <dbReference type="KEGG" id="kpin:30170477"/>
    <dbReference type="OrthoDB" id="270284at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.170">
        <property type="entry name" value="Translation machinery-associated protein 16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021346">
        <property type="entry name" value="Tma16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038356">
        <property type="entry name" value="Tma16_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13349">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13349:SF2">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11176">
        <property type="entry name" value="Tma16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF51394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC70622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="217" mass="24680" checksum="DD9D0BEAAE2EB475" modified="2016-11-02" version="1">MGNRKITKKAIKGKENLHPSSRKAAQLTRVNLRVDKLKGQTKARKDYADAKLQRPLFFLHSLSSPRPLSLPSLKALITEVYLGRFDGRIDELASERRAGRPKPKEMLELEEIKRREWNEYESGMEVPDLTHAPTSRLMYSWLQSETAMNVSHIDLLRHIRVSPNGEVILTKKGRGEEMGMGVPLPGEVEGEGEDWTGLSKEKEKEGMDVEVKWALHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I7E4</accession>
    <name>A0A1B9I7E4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ACB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_02194</name>
        <name evidence="7" type="ORF">I206_104656</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
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                <person name="Sykes S."/>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
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            <strain evidence="6">CBS 10737</strain>
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            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Berlin A.M."/>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
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                <person name="Imamovic A."/>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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            <strain evidence="3">CBS 10737</strain>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Gujja S."/>
                <person name="Hansen M."/>
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                <person name="Imamovic A."/>
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                <person name="Nusbaum C."/>
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            <strain evidence="7">CBS 10737</strain>
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    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
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                <person name="Sykes S."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I7W5</accession>
    <name>A0A1B9I7W5_9TREE</name>
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        <recommendedName>
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        </recommendedName>
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        <name evidence="10" type="ORF">I206_104801</name>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
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    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
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    </reference>
    <reference evidence="10" key="2">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="2">Belongs to the ISY1 family.</text>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Helix_hairpin_bin_sf"/>
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        <property type="entry name" value="Isy1"/>
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    <dbReference type="InterPro" id="IPR037200">
        <property type="entry name" value="Isy1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13021">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ISY1"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ISY1 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="213"/>
            <end position="279"/>
        </location>
    </feature>
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            <end position="199"/>
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    </feature>
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        <location>
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    </feature>
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            <end position="255"/>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="OCF51625.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC70849.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="333" mass="37147" checksum="26F7A323BC375B00" modified="2016-11-02" version="1">MARNQEKAQSMLYRFREQQAIDMGMGNRIKGDRRPRMASSVSSLRECERWRGDIMRDINRKVGKIQDVSLSNFEIRDLNDEINALFREKRHWENQIVNLGGANYKRGNVAMTDDQGREVPGTRGYKYFGRAKELPGVKELFERGATQATEESARNASFQMFRHQGPSYYGDEDEMDATLAEEEDELAQQEWEAAALASAKLLDVSDSTDIPPYPIASTSSTIAAPQASSSSSIKRKAPLNTEETDDVDANDDVEDDSSKKAKTTEVVNGNGESSVIPPKSIDEAMKSVQSTLSSFLSVLDPQSLQFPTLPNASEMEGVLLEVRKKALRDEYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I872</accession>
    <name>A0A1B9I872_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">D-arabinono-1,4-lactone oxidase</fullName>
            <ecNumber evidence="2">1.1.3.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">L-galactono-gamma-lactone oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_02466</name>
        <name evidence="7" type="ORF">I206_104925</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; D-erythroascorbate biosynthesis; dehydro-D-arabinono-1,4-lactone from D-arabinose: step 2/2.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.37" evidence="2"/>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012969.1">
        <property type="nucleotide sequence ID" value="XM_019154229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I872"/>
    <dbReference type="STRING" id="1296096.A0A1B9I872"/>
    <dbReference type="GeneID" id="30170835"/>
    <dbReference type="KEGG" id="kpin:30170835"/>
    <dbReference type="OrthoDB" id="610608at2759"/>
    <dbReference type="UniPathway" id="UPA00771">
        <property type="reaction ID" value="UER00766"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003885">
        <property type="term" value="F:D-arabinono-1,4-lactone oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007173">
        <property type="entry name" value="ALO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010031">
        <property type="entry name" value="FAD_lactone_oxidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762:SF1">
        <property type="entry name" value="D-ARABINONO-1,4-LACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762">
        <property type="entry name" value="L-GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04030">
        <property type="entry name" value="ALO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000136">
        <property type="entry name" value="LGO_GLO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="38"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCF51750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC70972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="479" mass="53590" checksum="0F4F23F805097D14" modified="2016-11-02" version="1">MSEDLLSVTNQTLQSSLQAISIPTSSSQATFTNWAKTFKCQPQRVFAPTTSLQCRQIIELARREGARVHPVGVGHSPSDLACTNGWLIKMEGLKGVVKINHEKNSATFMAGTTLHQVHASLAATSPALALPNIGSISDQTIGGLISTASHGSGVTFPVLSQHVRSLVLVLPLPGAPIVKVSPNDDPDLFKASLCGLGATGLMLEVEVEVEQAFRLKETKEPKSVDEVLDNLDEIKKSAEHVRVWWYPDGKGMIVGRANRTYQPAQPTASLLAHILGFHVTQFFLFVSRIFPSLTPLVGRWAWWLSKEESEVVDDGYKILNFDCLFPQYALEWAIDASLAKQCLEEMRVWLNQEAADHNGLRVHFPIEIRWSAQDDIWLSPSYGRETCWIGVVTYRPYGLAVPYRKFHEKFASLLVSHGGRPHWAKQHTLRPKDLEVVYPRFNDFKAVLQRVDPNAIMRSENVRRHIDGENVPDRMFKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I879</accession>
    <name>A0A1B9I879_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_02452</name>
        <name evidence="4" type="ORF">I206_104912</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012956.1">
        <property type="nucleotide sequence ID" value="XM_019154216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I879"/>
    <dbReference type="STRING" id="1296096.A0A1B9I879"/>
    <dbReference type="GeneID" id="30170821"/>
    <dbReference type="KEGG" id="kpin:30170821"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="283"/>
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            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
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                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Shea T."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
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                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
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                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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</entry>
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    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LplA family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013415.1">
        <property type="nucleotide sequence ID" value="XM_019153254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I9H4"/>
    <dbReference type="STRING" id="1296096.A0A1B9I9H4"/>
    <dbReference type="GeneID" id="30169850"/>
    <dbReference type="KEGG" id="kpin:30169850"/>
    <dbReference type="OrthoDB" id="201621at2759"/>
    <dbReference type="UniPathway" id="UPA00537">
        <property type="reaction ID" value="UER00595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017118">
        <property type="term" value="F:lipoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16443">
        <property type="entry name" value="LplA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004562">
        <property type="entry name" value="LipoylTrfase_LipoateP_Ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561">
        <property type="entry name" value="LIPOATE-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561:SF3">
        <property type="entry name" value="LIPOYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="5">
        <location>
            <begin position="81"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCF52196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC69572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="405" mass="46489" checksum="68F0C560DE60E295" modified="2016-11-02" version="1">MTMIPLAILRPCSSRFAASLFNQSTTRQFSSTLSRKEQKAAQPQTPATDSIELSAPVAYISESHDPWFNLSYEDWLLRNTPHEQPVLFLYRNFPCVVIGRNQNPWKETTPHHLREVGIPLVRRRSGGGTVFHDMGNTNFSIILPRLLFTRSHGAELVSRAIRERLGIKQCTVNERNDVIIKDGENELKMTYKIIQHRAYHHGTMLISSSLSELGKSLRSNSPNMQTKSILSHRSPVTTLNHYLPSGRNPIHHDEFIQAITAEFNKVYANGVNKKMETREVNSIWIKEPKVWKGVEELKSWEWQFGQTPEFTNLLEGQLSFGSISANLTARHALLISLTFHLEPLHNESTEKTMEKQNFLDSLALSLVGHRYESLEGVEGALDHQWEDEKWRERGNEVISWLRKVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I9H9</accession>
    <name>A0A1B9I9H9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deoxycytidylate deaminase</fullName>
            <ecNumber evidence="7">3.5.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">dCMP deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_01408</name>
        <name evidence="13" type="ORF">I206_103588</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.12" evidence="7"/>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013342.1">
        <property type="nucleotide sequence ID" value="XM_019153181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I9H9"/>
    <dbReference type="STRING" id="1296096.A0A1B9I9H9"/>
    <dbReference type="GeneID" id="30169777"/>
    <dbReference type="KEGG" id="kpin:30169777"/>
    <dbReference type="OrthoDB" id="6710946at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01286">
        <property type="entry name" value="deoxycytidylate_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000035">
        <property type="entry name" value="dCMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035105">
        <property type="entry name" value="Deoxycytidylate_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086:SF18">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="11">
        <location>
            <begin position="250"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="179"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCF52123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC69645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="397" mass="44281" checksum="128DD2360D70664E" modified="2016-11-02" version="1">MFIAIIGTPSSGKNTVVQYLERKYGFKRVRLDKKEKNKEVSGESKLNGIELDHKSNELSVSSSTSPAPSSPLESPSNNSDLKFTSLSTLLDFITRNWLLNHVTTDLISFEDIEPFVKRPFFLCINIDGPILIRFQREREKEKSKSLLNNNENQLLSLEKFIQSHDELLNGSLPSLPLLSSSSSSSSSSPSSSNKLISDDDNNNQQQQQNDFRKSLSLSQISICNNFKTIENFENYLDNLNLINEERLRPGWDTYFMTLASLASHRSNCMKRRVGALLVRSKRILSTGYNGTPRGTKNCNLGGCTRCNGSARGGEALNECLCLHAEENALLEAGRDRIGDDSVIYCNTCPCLRCSVKIVQCGVREVVYNQSYSMDEASAAVLKEGGVILRQLHMPGQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I9J3</accession>
    <name>A0A1B9I9J3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_01511</name>
        <name evidence="11" type="ORF">I206_103485</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013444.1">
        <property type="nucleotide sequence ID" value="XM_019153283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I9J3"/>
    <dbReference type="STRING" id="1296096.A0A1B9I9J3"/>
    <dbReference type="GeneID" id="30169880"/>
    <dbReference type="KEGG" id="kpin:30169880"/>
    <dbReference type="OrthoDB" id="2130629at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="519"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="79"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="554"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF52225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC69543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="585" mass="63791" checksum="B15BA05A3DB30870" modified="2016-11-02" version="1">MSIRSSDYIDDIPISNLTKNEYTNFHVQTEINQDVAEDISAEIPPDGTVSKSSLPIPINENDVPSPDAPKLSKVRQIVIAITLMFLTFMSASGGQALNIGLPTIQKDLNMRDVDLQWISSGYQLTNGCLLLISGRLADIYGRKLLLLIGMCWFALWSLLGGFMQDGVGLVISRAMTGLGAAMAMPSATGIIAHTYNGRARQIAFACYGAGAAVGGALSLIIGGIFVSFVKHTWRSALWFLSGLGFVATITAYFVIPWDSSHTKDKSLDWPGAMLVTSGLVLIQYVISAGQSAPNGWKTSYIIIFIILGVLLLVAFFLWEKRVIDKGNKPPLMRLQLWTRSNGRLSAVYFIGFSAWLSFSSILYYGTLFFQEVQLTGPIGAMLRFLPTEIGGLICNVLVGLLIHRIPAQWIVCCGLLSVGLGNMCFALSEKNTSYWALPFHGMWLSSAGADFVFAPGLIFVSLLSLPDEHSVAGALFQTLLRLGGSMGLAITSVIFENVKNKSLKKNENENESYLKGLKAAFWLSASFAWLGLLVGLLALNGLGILGNIKQNDGKEEAQINLNKARIENENLVLEERIDENNRNQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I9R3</accession>
    <name>A0A1B9I9R3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_01539</name>
        <name evidence="3" type="ORF">I206_103458</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013472.1">
        <property type="nucleotide sequence ID" value="XM_019153311.1"/>
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                <person name="Heitman J."/>
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                <person name="Springer D."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Berlin A.M."/>
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                <person name="Dewar J."/>
                <person name="Goldberg J."/>
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                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
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                <person name="Berlin A.M."/>
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                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
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                <person name="Zeng Q."/>
                <person name="Chapman S."/>
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                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="Gargeya S."/>
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                <person name="Alvarado L."/>
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                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="David-Palma M."/>
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                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
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                <person name="Cuomo C.A."/>
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        <source>
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        <source>
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    <sequence length="193" mass="22583" checksum="26F88EFAEC5742EE" modified="2016-11-02" version="1">MNFKYPSFKIHQSVTRFCLPLSRFSKLPSNQNKTLYIGSIITKSIKNSTTESIKILIVKRQLLNENENENSFKWEIPNGKVKYGIDQTLIESIIRIIKDKIGLIVISIKKEIDSFEYQIDNNQKTYKQYNFITEISINDNHSDEEEVLLNSKEYQAYKWITKEEVLNLDMTDTMKSVLVNGFKSIEQIAQQTE</sequence>
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                <person name="Litvintseva A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="David-Palma M."/>
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                <person name="Bowers K."/>
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                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="Mohammad A.W."/>
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        </source>
    </evidence>
    <sequence length="996" mass="106329" checksum="4202FF9DAF968D0E" modified="2016-11-02" version="1">MGPNRYPELGRTATTFTSHPTIPLNEELPFLPPLPDTPQHANKSYSKKWDVEIDYPVLTTRQAVFNTPSAINRIPSSDLLKTNGTSSQSKYKENTPSPDILRTVVQPSKAPSATPHPHDLILKTTKVPCDIDSPFTKHTDSGSSGSAIKVFTTELPQPRLSASFNFGSYVADHSLLADQSLMASSSADEDSFHLDTNTVRQKPHLSEETNPLSCSISSQTQKGTSAPEQTFLSIPPNALDQSTLLPRSPAKTAHLLDPKNAINNVKPPWQDESEIFETCIDISVSSREPSLSPERTTSSSPAKSTMSIPHSQNTKGFPTSFSSHSLVSIPKIKRTFPASSSAQSLASLGEEAEGNEIAGDISTLLPVSPMKTAHLLTDPELITNEYLNMEEEKSFRLPLPSRATPFKPSFMSKTPRKSPPARMSPIKAIVQGIHSHNVAGLEAGDVTFDVKDLLARVNKPKRASGTEESFVDLLHDDLMFDGLDTSMMGPDESILPPSLRPRSIRGRPTSPIKPNPNTSPVRMARPIEPATIKRHQSNQGSTQQRDLPSSTSTHDLVDRHNQEERQESKLATISRSKSLSRVAEIVERVKSERNVRAQPDRVTNEKGQQEFNVPLSPPKTALRARTYTTARTPTLESGSTSSKPRNSIMPPSATSRRISLSAGSLPLAGTASHKAMQLPTSQSTMADPLPPVTGRRLISARTAATTGSNTSRLTGAAPVTAQPALRAARTSMAPPPPPSLALTSNEMKSKARFGSASNSISTSTSASESTVTSRSTVNRASRPSTVSSNIPSSRVPPTTASSARPPVSTASRISRPSIIGRPVGLPKPGDGLSGRSATSTTSAIRPDGRAKLSRGFGTDASGTTNRVVPRPSIAVSGKVSTGQTLSAMKSRSLSTPASSTITTKVPLLPTLPRNVKPITTREAMAKKSSLPPSSVIQTQRTRVGSTNATTLIGSGGLPRPSIRSTGSSKSSAPPGNSGSLTALRERLDKLHAKQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IBM9</accession>
    <name>A0A1B9IBM9_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_00300</name>
        <name evidence="5" type="ORF">I206_101026</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF52999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014218.1">
        <property type="nucleotide sequence ID" value="XM_019152080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IBM9"/>
    <dbReference type="GeneID" id="30168669"/>
    <dbReference type="KEGG" id="kpin:30168669"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF7">
        <property type="entry name" value="NADB-LER2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF52999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC67119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="25843" checksum="6C276DD56C91A979" modified="2016-11-02" version="1">MTTVFISGGNRGIGLGLVQKYAARDNYTVVVTARDPSRMPKVDVGSGSKVVVVTMDQAKKDGCLEAVEEVKSKGITSFDIVICNAATLLVEGYAKLRDVPLWAFEEHWRVNVLGFLAFFQAAVPYVKKGGKFIFISSGSATIDQVPRGYEVTYGISKAGASYLGHFAHYEEPDLVIFPLDPGWTQTDMGKASAKNAGVDLPPLTIDESTTGLIKVIDEATRETHGGKQMRYDGAQNKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IBX1</accession>
    <name>A0A1B9IBX1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AttH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_00222</name>
        <name evidence="5" type="ORF">I206_101104</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF52921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014140.1">
        <property type="nucleotide sequence ID" value="XM_019152002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IBX1"/>
    <dbReference type="STRING" id="1296096.A0A1B9IBX1"/>
    <dbReference type="GeneID" id="30168591"/>
    <dbReference type="KEGG" id="kpin:30168591"/>
    <dbReference type="OrthoDB" id="5344254at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057722">
        <property type="entry name" value="AsqO/PenF-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056402">
        <property type="entry name" value="DA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25581">
        <property type="entry name" value="AsqO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24137">
        <property type="entry name" value="DA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159245">
        <property type="entry name" value="AttH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628504" description="AttH domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Diels-Alderase N-terminal" evidence="2">
        <location>
            <begin position="31"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="AsqO/PenF-like C-terminal" evidence="3">
        <location>
            <begin position="231"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF52921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC67197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="40699" checksum="D0415EF525248922" modified="2016-11-02" version="1">MVQLKLITIALTTFLLPLNIQAKPPKNYILPNIIEGPVSIETQVGQGSYDRAYIQTHNESSYEWWYFDAISSDGKSSIVLISLVTLSELGQGTELQGQIVTPEGEIFSNRSDYGPEGKLWVSTKGDGSSGIIGNGDFTWIGQPDLSQYVLNVNWPEKEMTGTITLISNASPFVGCDAFGPDARTDTFWWFNWINLMGDAVAIVDLKVGDKKIAFTGNGYHDKNWGPVSFPSYVNYWYWGHGRAGDYSLVWSRIVDKDNITISSAWLTEGGKIIHSTCVHDDSIQVIPFGNNITIPPNRPNNTNNIDGFDININTGERGKYQFKFDSNQWTNGNQGNYARWIGNFKGGKVGDEPGIGVGITEQMGPFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IBY1</accession>
    <name>A0A1B9IBY1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Required for respiratory growth protein 9, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_00242</name>
        <name evidence="6" type="ORF">I206_101085</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for respiratory activity and maintenance and expression of the mitochondrial genome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRG9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF52941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC67178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019152022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IBY1"/>
    <dbReference type="STRING" id="1296096.A0A1B9IBY1"/>
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    <dbReference type="KEGG" id="kpin:30168611"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="NEUGRIN"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
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            <end position="196"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00003548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1B9IC90_9TREE</name>
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        </submittedName>
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        <name evidence="11" type="ORF">I206_100942</name>
    </gene>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
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            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="OCF53083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC67035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019152164.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A1B9IC90"/>
    <dbReference type="STRING" id="1296096.A0A1B9IC90"/>
    <dbReference type="GeneID" id="30168753"/>
    <dbReference type="KEGG" id="kpin:30168753"/>
    <dbReference type="OrthoDB" id="1405595at2759"/>
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        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="41"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="71"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
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            <end position="394"/>
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    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="932"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1019"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1054"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1139"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="344"/>
            <end position="361"/>
        </location>
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            <begin position="362"/>
            <end position="379"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="380"/>
            <end position="394"/>
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        <location>
            <begin position="933"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1025"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1065"/>
            <end position="1088"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1139"/>
            <end position="1152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF53083.1"/>
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        <source>
            <dbReference type="EMBL" id="WWC67035.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
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    </evidence>
    <sequence length="1176" mass="128333" checksum="7B2708FB4A8D2A2B" modified="2016-11-02" version="1">MPARRQSGLSPIDPITGLPVEGATPTSGRSRGKEGKEKETFACTFPGCGQNYSRMEYLKRHQRKHQDDRPFQCKDCTKAFARSDVLLRHRRRCHPTPPPTDRNSHSPPAPHRNYPGVPVSSSRTDARDASPASRSRKHPRRSSGDDERDATRPRLDPSLDPSLEDDFTGADDDDRYPDGTRFNRQNGMGNGGVYSSGNPFYGSGAVPEGSTYTPHLLPMFQQGQTFHSLNDADHLEDASVLLSMAYPGGVPSGENPDIQRDLPDWANNPTINMMMEAAVAANREQEANKTVNGNDQTKEVQSTEQPVVDPALASASGNVTNNGDDSFLNTMSWLSGMGTQGVLNQSQNQSQTQNQNRISSQMDISQNRTGQNSNSQKKGSTSTQNSTQQSTQNLSSADMGSLLGWMQLFASNMNGSSGPGNSPKAQTPFPISSLFSPSAFGLNNVSSNTDGENKDEVPPMSPSIMGILDQMAMYEVPQTLANPNPERPLLRLANSEMNTRAGQEWFDKTSPFYLPADRFAGVYQIPHWALPPLRTLSVMACRTYHTVLNHFSFVHMPTFKLNDTAACLAFAICTVGGIRTGSTTAADNAVLQSLGLSGLIPPKSLDGPVVPDQSWESIYESNWNRANDDKALDSEKVTAWKNGPLVRNEKTNMLVKSFSLAQGVLMTEYNVALLQALILYHTPNFLSESESERLTANMFMGTIVNITRQIGFFTPEADHFTTKIDTPTEPFTPNDLDRCWKKWIQLETRRRTAYLVYQLDTVSALESNIPCILSSCEISYLPLPAPDTLWKAPAAVDWLKAVKKYRPMTLDEAMRRIFFLPTFGSFDNLHENADTKYYNLLNTQDLGPFARLALVLTLLRGVMDIGEGKRDRGDWRDLTDLWVGCGWLRPTKRMLAQDGTDLGRITRESLRGRFGMGLQKWREGWDFDRLCSSPATPNGSRADSAGVSPQSNSSPPGREPELPKETLNYCEDALPFYWLAVALLNQLNNSTHNEPGFNHFSGVKYGDMLKAARTFTRTGEGIPGATSNGSSPSYARQGSTSTASVVSATVPAASAQTQNTAHTYSAPSSTGTSNSLSSISPPNNNNKTVDIPPVVEETNDDNFDLSNMSPGTINGFFEAIAGAGGSEDTFDGGTVPISTKQNPSAGTTGGTSQQVENGGGGIAGQGQLYEQIGFII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9ICH2</accession>
    <name>A0A1B9ICH2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Bacteriophytochrome histidine kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I206_00435</name>
        <name evidence="17" type="ORF">I206_100891</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="OCF53134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_019152215.1"/>
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    <dbReference type="GeneID" id="30168804"/>
    <dbReference type="KEGG" id="kpin:30168804"/>
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        <property type="component" value="Chromosome 1"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009584">
        <property type="term" value="P:detection of visible light"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
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    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
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        <property type="entry name" value="HisK_dim/P_sf"/>
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    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="PAS_2"/>
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    <dbReference type="InterPro" id="IPR016132">
        <property type="entry name" value="Phyto_chromo_attachment"/>
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    <dbReference type="InterPro" id="IPR013515">
        <property type="entry name" value="Phytochrome_cen-reg"/>
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    <dbReference type="InterPro" id="IPR043150">
        <property type="entry name" value="Phytochrome_PHY_sf"/>
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    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
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        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
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    <dbReference type="PANTHER" id="PTHR43065:SF10">
        <property type="entry name" value="PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43065">
        <property type="entry name" value="SENSOR HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="BCTRLSENSOR"/>
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    </dbReference>
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        <property type="entry name" value="REC"/>
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    </dbReference>
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        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PHYTOCHROME_2"/>
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    </dbReference>
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        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0157">Chromophore</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="1" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Phytochrome chromophore attachment site" evidence="13">
        <location>
            <begin position="944"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="14">
        <location>
            <begin position="1320"/>
            <end position="1558"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="15">
        <location>
            <begin position="1757"/>
            <end position="1886"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
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            <begin position="1"/>
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    <feature type="region of interest" description="Disordered" evidence="12">
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            <begin position="411"/>
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    <feature type="region of interest" description="Disordered" evidence="12">
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            <begin position="671"/>
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    <feature type="region of interest" description="Disordered" evidence="12">
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            <begin position="761"/>
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            <begin position="890"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1561"/>
            <end position="1602"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1639"/>
            <end position="1755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
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            <begin position="34"/>
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            <begin position="108"/>
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        <location>
            <begin position="159"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
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            <begin position="240"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
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            <begin position="253"/>
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        </location>
    </feature>
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        </location>
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        </location>
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            <begin position="418"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="431"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
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            <begin position="534"/>
            <end position="545"/>
        </location>
    </feature>
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            <begin position="692"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="768"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
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            <end position="803"/>
        </location>
    </feature>
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        <location>
            <begin position="804"/>
            <end position="813"/>
        </location>
    </feature>
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        <location>
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            <end position="847"/>
        </location>
    </feature>
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        <location>
            <begin position="896"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="909"/>
            <end position="918"/>
        </location>
    </feature>
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        <location>
            <begin position="1564"/>
            <end position="1573"/>
        </location>
    </feature>
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        <location>
            <begin position="1574"/>
            <end position="1583"/>
        </location>
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        <location>
            <begin position="1584"/>
            <end position="1602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1659"/>
            <end position="1669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1731"/>
            <end position="1751"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="11">
        <location>
            <position position="1807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCF53134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="WWC66984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1920" mass="207729" checksum="1C56FEDCE50CDE23" modified="2016-11-02" version="1">MSPQDEQPRQSAQTPQAAQPPQAAPTIAPPTRPTPTTTPQGSSESVPSNKSSNRSSHPGSVTMPARPVYAPGQFTTGHAQKPISPGHAPGHPNRKTTTPTSEAPRHSPSISPSVMGSTGPLSPSSTYGGNSFVFPMRSVFQGLNSSDGQQGESSTGLNRTISRSSDTRTPSSRHDPNRRFSQSMLTGDGDAGIQSIAQLLQQQDDRENDKPKDKVKGSVTFSGHRSDRMSKGLSTPPTPSTTNTFPFSDFSTLQKDQNSGPSSRRTSAEEVHHTERPDLTHGGSSGTVKHFNEDPPVSNPSADASGSGLPDKSRPPVGVPQGAPATVNFKDYPADQDNAGETTDFSAPTKEERPPPELKQPKPIHPTADTLDQLTRKKTSSASGSKTSVEVDESGIQALVNDFSGIVRLGEAGSFTTGTGGNGTRGGSGTGTRSSAGISAGSKAAGGKGGPSGPTTAARLAQQQRQQGPNTTRDTVRDFINSQARTVNMDDPNAPTPTPMDEESVAHEPATSENLTGPTPAEEIQWAEDKEEASAPASSEQAIASGDEKDEFTATSSEAGSEPIITFRFEHVSDNDGHHVVVGREGKLRRCEDEPITTPGAVQGFGVLLVLEEDYESGALAVRQVSENATELLGLSPKYLFALDCFTRILTIDQEDVLRDNLEYLPIAEGGKGSVEEEGPSVFLLSGYGEPGSDDSEEEEGSATSGGSVNGRRREWTCWAAAHRPKINSTEKKDENGISIPLPDLIILEFELERDEYNPLIQPFESPSIDSTTGSDTPESGRGSFTGASLGSVGSTGGAGSGGSSVTVGSTTVPGRHQGSEGSTVMTAGGNSSTPNTSQHASTSHPSSMLPPGSKPMGLDGLEFEVPIERIIESTTNHAKPLRALERMRRTGQHGGSSVDSGSGSRNTRGARRPRRRPPAGTTGTMDVFAVLGQINDQLGASPDLETFLKITVGVIQDLCRFHRVLIYQFDETMNGQVVSELVEWGKTTDLYKGLNFPAADIPAQARELYKINKVRLLYDRSQTTARMVLRSKEDLDTPLDMTHCYLRAMSPIHIKYLANMHVRSSMSVSIMAFGQLWGLIACHSYGHHGMRVSFPVRQMMRILSDSISRNIERLSYAQRLHTRKLISTIPTQAHPTGYIVSNADDLLQIFDAESGLLVIGDGCKLLGQNDQGQAMLAIAEYLRVMRYDACKASNHIQRDFPDLVLPRAQDTIAGLLYVPLTAKAGQDFIVFLRKGQAREVQWAGKPYKDDRAGDSASLEPRKSFKTWSEIVTGRSRAWTDDQLQSAGVLALIYGKFIQVWREKQSAMASNQLTAILLSNTSHAVRTPLSQIINTLELALSGNIDADVRNMLENSHQASRALLFHVHDLLDLTRIETGNEQSFNDPFDIRQSISDAIRLYQTESSRRNLEFRVIMADNLPQYVIGDSRKIKTVISNLVANSVKFTEKGFVEVYCGLQQPSSSDGAASSKHAQQEIMRGGHVPIEIVISDSGCGIATDKLEAMFVTLEGADELKGSSSNGLGLGLAVVARIVEQLEGQLRAESEVGVGSRFFFTLPMLVHHGRPSSKSSKESAANGNDNHNNNNQSLAIRTRTGSSGSNSVASLRSGLSEVDSFVNDFGNSHMLSQPVPADDQRIKDAEYRMSRPGTFPVTDSSWPVKPSRMDPDSDQSVHTDASPTHGRSPDFVQPPRLENTRRISYRPNKEQGGHARHQSHSSINKTRKDSSSSAQSVIDSERRESASTDQPKRSTKTADGRSTLRVMVVEDDMINSQILQKRLKMDKHTVKAVTNGQEAVTALQADWDYDVVLMDIQMPIMDGRQAAREIRKLEAKLESQRDIEPLRVDGRIPIFAVSASLYESDRHNLAEHFDGWLLKPLDFARVRTLLAALEDPAKRSAEVYEQGHWEKGGYLRAAPSPSSSPDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9ICI8</accession>
    <name>A0A1B9ICI8_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_00624</name>
        <name evidence="3" type="ORF">I206_100703</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014541.1">
        <property type="nucleotide sequence ID" value="XM_019152403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9ICI8"/>
    <dbReference type="GeneID" id="30168993"/>
    <dbReference type="KEGG" id="kpin:30168993"/>
    <dbReference type="OrthoDB" id="2565076at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
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        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="397"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF53322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC66797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="593" mass="63248" checksum="ED232DE40CE4562B" modified="2016-11-02" version="1">MIPTTPVFISPEVSTYSLDPSPRPSIASSNCSGASLLTPIDELDKMSSDLTINTEEVEEVNAELVINAKETNDSFMRRNSKANLPNLTVPPPAFSNFSFGTFSPSASSSSSIGLTPSPLSSTDDVALPSEGFKFGTCPTDSFVGTPTAEQGPFEYPVASGSSSGFSASPPRSSPTLARRGSLALGMTHRRGSIIASHPHPNITSSHGLSPPPTRRSSTCSTITTLPIAGRRPSIIHSATVEVNLPQTHPSVPPFEEPPPSSASSSRRPSVLMFPSKPLPAPIPPSLLARRGSLPAAQLFGIPLSDQPNRTRASYSSGSNPVSTASLYLRRQSMASESGFSNGSGATVMENSGLGDDHGSRRLSMRSGISSTENDKILPLSSQRRGSLSFFPPIPAQSPIRSSSISSTSTRSSIASSSSSIRSSTSSRVPINFSPRHPNYAHTYGPSRQSSITTTSTNSLPCSPKVSKINRRNRKSITEISHSSSSSCEGNSNLGLSSSEEENENENENEEELPTPNNIINKKIEFNQNQNQIPSIVPTFSNPWNNTNLIENKLNDISIIENNKYNIPLETPPLETVLERPPLETFDSGATEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IDB7</accession>
    <name>A0A1B9IDB7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Haloacid dehalogenase, type II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_00611</name>
        <name evidence="3" type="ORF">I206_100716</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019152391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IDB7"/>
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    <dbReference type="KEGG" id="kpin:30168980"/>
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    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
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        <property type="entry name" value="HAD_2"/>
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        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF9">
        <property type="entry name" value="ACID DEHALOGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF53310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC66809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="235" mass="26727" checksum="C0552D293C7D85B5" modified="2016-11-02" version="1">MSLAPFKVLLFDCYGDWETGMINNFKHLLDQPTSPDRTKLFEIVGPIENKIQDDDPTLLYSEVLTKVYSETAKKLNLNFDEVQAKSFGKSIPSWPAFSDSSKSLKKLSDAGLKLVILSNVDNESFEGSRKRLEDGYSFDAIYTAEKIGSYKPSLKNFDYAIENIKKDFGLEKEDILIVANSKYHDIQPGHKKNLKSAWIDRAKAHMGVEAYKDVKPDYQFQSMEEFANAIIKDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8KZB5</accession>
    <name>A0AAJ8KZB5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_101134</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014110.2">
        <property type="nucleotide sequence ID" value="XM_019151972.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8KZB5"/>
    <dbReference type="GeneID" id="30168561"/>
    <dbReference type="KEGG" id="kpin:30168561"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="505"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="546"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="578"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="603"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="638"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="672"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="308"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="99"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="241"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC67227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="701" mass="76099" checksum="35CD3FF2A8B5A94D" modified="2024-07-24" version="1">MSDYIHSQEHSNDVTITQDNIVPLEQREESNHVVPRLSTIASSTATLCMTDTEYDEVKPDAKDKEVLNSTGKANGIEQSTDTCQLQRSQSISTTYNAHTNRTHNLAPRNRSQTIAQPAGRRKVSLRRSSTLDDGPPPPIPAPGDVIAVLDPASVGGGGPLKRVETARSERYEQEAAERLQREANGSPRPNSGSEGILRRFRSASNTTTKRPIFNVPLGLHDHHEHDDEENSLSGYKLKFHKPTLTPTHSRKSSAVNSLAASEDGKEGGHTSTDSEKGQGQNHGDIEIQQQINFEDHVYPDGGYGWIVLISCVVLAGCTMGWNMNYGVFQEYYASNVFSNTKTSILILPGCLNGFMMNFSAFLSGRMGDRYGFNRVLYASAGIFWLGLFLASWSTKLWQLIFTQGVIAGFGQGLALPLFMSLPSQWFYRRRGLASGIAIGGAGLGGGTITLVARQLLSTVGYKKTLLILSFVELFFMLLATFFLRTRPTSPEARSGKTAPWVDKEVVKTGAFWSIMIGTVVGTTGYAMPFAFLAQYVRANFPISDPILLALPTTLLAYTLCIGRALVGFVADKIGPLNTYILVFVISGIIQFALWLTAKTFGGVLAFAVMFGLIAPGFSGILPQIIVQLFGPANLATNVGLILLSGAPGNLINGPIGGGIYDSTNRTTFKYTIIFGGAMQIAGGIIACYARYKTSRKFLVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8KZF0</accession>
    <name>A0AAJ8KZF0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_100116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019015123.2">
        <property type="nucleotide sequence ID" value="XM_019152985.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8KZF0"/>
    <dbReference type="GeneID" id="30169580"/>
    <dbReference type="KEGG" id="kpin:30169580"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019416">
        <property type="entry name" value="NCBP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16291">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16291:SF0">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC66215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="428" mass="47355" checksum="FCB188478FFB88A3" modified="2024-07-24" version="1">MALPYDGTPPPSPPREEENPALDRALDDYTPALPDHVQSLMGRMSRGKVYLMEESPAILHLDGEDKLRRDPRIAALAQRLDKQDPTAWLEAISSSTPSPIKPNALYVRSDLIQHLSTSKIFSWTSGLGAGVMGIEWLNDTTLHLIFPTAAAALLGLTVLSKAGFDPAEGDDPLLERAAHSIPFSLLPLAEPEPVPSLEGQELLGESSTPKENEGIKRKGRGTFGSKSGIFDLEPLVSDRNDNLSEIKLLEGVNPHSRIAIRYGIELDQDLRKQAKQSEWYKRHGKHAGKETSSRIRNFNNNNNHEDENGFSFSGRNGGEGRDFAKRLGRGGGRRDQQPYGERPNKGRGRRTEEDLDKDLENFAKRRAAGEDGVIDEDIEMDRDNLSNDRRRNNGNRRGGGGGRRGGAGNKEDLDRELDELFANRSTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8KZW2</accession>
    <name>A0AAJ8KZW2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_100850</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058385.1">
        <property type="nucleotide sequence ID" value="XM_070202284.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30168845"/>
    <dbReference type="KEGG" id="kpin:30168845"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055122">
        <property type="entry name" value="Med14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013947">
        <property type="entry name" value="Mediator_Med14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809">
        <property type="entry name" value="MEDIATOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08638">
        <property type="entry name" value="Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit MED14 N-terminal" evidence="11">
        <location>
            <begin position="202"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="160"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1072"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1072"/>
            <end position="1089"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="WWC66943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1285" mass="142103" checksum="8CACEC4D7FE5EF8C" modified="2024-07-24" version="1">MASSSAGPAPSSSTGFGISGISDLPNHASSSTQPFTKPRNPQLSNEPWFAYPTPTAEQIEEELPPYFEGENVPLGPLLDRLVRKGYGDLRYLLAEILPPLSAKQKPKHIINYATTTRQALLKYLAVLRWKSAVDVPSSYPYASSSTNLPSHINGQNGMINNFPTPHSNGDDTSPASISSTNKGKGKAQATGVDNEDVLIKGKVTDSRRLAQFMEHQNKQHDDAVAHLQHVTKLVESLRERNPDLLTAIALVTTGTYQRLPTSITESFKPQPPLTNSAILSLLRKLNRQIKYRLRCIDYIPPDLVVEGIRDGQVYFIGGGEHGWRIRMSIVGFGVESKWWLTGVEWLWRHRERGVNDPGGESSRLEEDDAASRGKKFTGEERQSILDLANLEILPPRVDQAEDSQADTTKKRSNHVAQSAQLESEAIAATDGESLTQVTLGEVEKEEAKDKVMDAPLVRIYNFIQHLSLSYQLEILFTQAMALSQGKWRNQLRVEIDRDTKTLKVKYWIRPRPAVIPQQQQAAVGKRPTLVSSGGSSRTPLVGGVISVSLSEANIPQNESAAFMGLVASGQVTSDERVLNLRLGVKWEVGELGIGGGLKVGDVMDGGSLQIDPASLDMENLIMTSARAHAAHLTRVQASALISSPKFILSLLNQPTLQESEDPTSSCPLTLRIPIPSRQNVSSLIIGVSAYNGHIEIEDDGSIGNEVRAERVELAMKSINDGKTRLVDDIGRLTVAVVMENLEDQMRQLGWKPIRRLALRSQDLAKVQLHPATTVLTPILSAPTYYFVAKVTQAGLAFELLKVIKVPSETGMGVGMKSAVGDRIPLDLERLKSREKGKEVDGTLNGTLFEIGNKDLKNLYIYSNALVAQTIIENQLKERNIPFTAQYPPTTQSGPNVTRSSSALAGMIPTICVDVRDLLRNGTRGAAVDVAMPKVGMQIENWWTGGKCEVSTIVRLRQQSSMTQTSTNGLSDINTPQAHSEDISFDPTSSIVKFRAKEIERCVPAFLEQWERLSKVIVVAGEVNRLNKYAEFSDIKMLSFDLRTATLSYSSDYEASITYLPVDDSYQVTLSRNNVPIPSKPSTENTTNIDNPHERLSSLLSARLTELAATPLEGIPKGAVGREFFGLLKNTLPFFEQVEKLKERGWDLIVLDIRTYRIMKDYKGRRYALDIILIPALSHYLIQSSLKPKGPDKKLDFEIIGQITELPLNKIIPKIYNNLKSSSSSSSSSYHLKNLINSNDKEIINIPPLMKLDKDQSLICKVNLIQNVLIEFMDKVDEYIGFKKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L0A6</accession>
    <name>A0AAJ8L0A6_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_100953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058402.1">
        <property type="nucleotide sequence ID" value="XM_070202301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L0A6"/>
    <dbReference type="GeneID" id="30168742"/>
    <dbReference type="KEGG" id="kpin:30168742"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC67046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="362" mass="38389" checksum="649E6935033B54C7" modified="2024-07-24" version="1">MAEVWISAASPLLKYSPSNSNWVQQTDGSVQYHGNEPFAVELNAYFSSISWYYDQLSSQKLQVRIDGSLEEGSAQSGSASLPASFNTHTAKLQSDCKDCGSAGSSLFILQGVKLLTQLVETGTLDDASSQITYTGFQSATAPNSDITAIKTGTFQGDTVSYTSSGGASASFSFQGSAVYIFGMTGPGFGCYEVKVNSQVIGTYNASSSVETYNSLLFFTTYLEAQQNQQVVITNQNDGCLFALDYITYVVSGSSGTNSTGTSASGSSPVATAIFPSQAGSNNNNSTTTGDSGGAVIGGVIGSLAGLFLLWVLWRLRQWKKGGGQGSFMVALCGGFKTKTGEEKEENKFHLWPMVWARPKYDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L0P1</accession>
    <name>A0AAJ8L0P1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carbohydrate kinase PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_100869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019152237.2"/>
    </dbReference>
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    <dbReference type="GeneID" id="30168826"/>
    <dbReference type="KEGG" id="kpin:30168826"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47098">
        <property type="entry name" value="PROTEIN MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47098:SF2">
        <property type="entry name" value="PROTEIN MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="1">
        <location>
            <begin position="165"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC66962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="383" mass="43530" checksum="B240569295837F6B" modified="2024-07-24" version="1">MEYLSPRSDEFLKSKGRVTTLGMFIIDHYAIRDENGNEIMTEEESIGGGGVFAMISARMFLPPKQCGLIIDKGYDFPQKFINTLKNYGEEMIWFRNRPDKTTRALNIYSGSKIGEGHQSFKYLSNRINLFPNDLILNPSTPFINENENNLPEYIHLVCNIERAKLIINEIKNINLKEINKINNKIWNPKLIWEPMPSSCISSEIENILEIISNFLIFSPNLIELQSILGITSSSSNNSKNNPTKKDVENSIKILINLFSKKYENTNIPCIIIRSGELGSYTFSKNWKGWIPPYYDFNKQYKVIDTTGGGNSFLGGLAAGLLISNDDMRIASIYAATAASFTIEQRGLPSLSKSPDGERWNDDDVWRRLRELASRVEKVNSDQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L1Z7</accession>
    <name>A0AAJ8L1Z7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_101989</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144520">
        <property type="protein sequence ID" value="WWC68070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058587.1">
        <property type="nucleotide sequence ID" value="XM_070202486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L1Z7"/>
    <dbReference type="GeneID" id="30175288"/>
    <dbReference type="KEGG" id="kpin:30175288"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="473"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC68070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="589" mass="66777" checksum="A6993182B29BA6A1" modified="2024-07-24" version="1">MTQWRDAPYLHFPNSTYLDSLSNNTDPYTIYYGQAAVVSSTQLTGYAILNIIGIISLSFLVGTILLSGCNLIPNFIRNRLPLSKETKSGKLRKNLIRRRIILGTKIQRDPCLINAFIVIILVNILNLLYWMANNGKISSEEIIYLPHPKLCRAQAILQAGSQSAQMSVVLSVVLRLWLKTITLTTPRFDRFRGRTTLLILLALPYLFVLGFVPRMVILTMDSKAPLLIPTPFYCSLLDLNIRKAYQILTGVIAIITLIMELWVIFLITKHFRQTSRTSNLANASMTSKHGIKINLTKPQRILKRSFYIRVSLFVFWTIGMIMATLYQAFDKTITDSNSDFVFGSMGLIAFICFASQSDILRSWNIPSNSEELIFFLNKHFKFILKKKNHKQNENYLPKNDNDIKRDNNIINNNNNNKRREILPTTSLPQSVINNQQQLEFNLYDFLGDSSPGRKEEEIEDEIEIQNFINTNTTTSRITGTSGSNISSSSKRPEIFSSQGDLKEEDEYYEEKLPIENFDISTSSNTTTTGLGFNMDLDPPSLFGSRGMIVTLQEGMSVEEDLNLVVSLNKNGTGENGGIGQRTMDTRDMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L3J4</accession>
    <name>A0AAJ8L3J4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_103326</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058826.1">
        <property type="nucleotide sequence ID" value="XM_070202725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8L3J4"/>
    <dbReference type="GeneID" id="30170037"/>
    <dbReference type="KEGG" id="kpin:30170037"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039903">
        <property type="entry name" value="Zswim2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21540:SF0">
        <property type="entry name" value="PHD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21540">
        <property type="entry name" value="RING FINGER AND SWIM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="4">
        <location>
            <begin position="220"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="334"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC69387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
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                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
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                <person name="David-Palma M."/>
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                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
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                <person name="Sun S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WWC69734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="130" mass="15716" checksum="37BB2A7FCBCF4017" modified="2024-07-24" version="1">MDVFKELGRHLNENQRLEVYNIDKLVERLNHTEFMNIEEVENLLVDKLDQGILEKINKNNKASKLEKMKNYKIKVDFYSAKQYYPEFIELDMIVDEEARYWEYRLFPSDEMNSWDKATQDDAIRTESLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ8L4U5_9TREE</name>
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        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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        </lineage>
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    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
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                <person name="Dewar J."/>
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                <person name="Howarth C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
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    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
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            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="kpin:30169809"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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        <location>
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        <location>
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        <location>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC69613.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="27286" checksum="A0346EEBE0C7DAE4" modified="2024-07-24" version="1">MPIKSTQRVAPANQYPPDAMPKIGRIIFHIGVTAAMFDGFWGLQNLALTKDYIGTQYGGHFQYLTILGLFGTIITMFLSGVCDYLPAIQSLKTIKRVFLLFAMPVELVISSIYWSIILFAPELMLPPNPELSSSSEPSAEAKDPLFRIPLLMDLSMHALPAVALAIDFFFLEKKFKPPASNIGSFVLAATFGTGYSLWVEHCASINGSFPYPFLTIMNFQQRIMMYVGSTLMAWLVFRGLNAIHK</sequence>
</entry>
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                <person name="Litvintseva A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC69371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="171" mass="19566" checksum="C8997F9F4FE91236" modified="2024-07-24" version="1">MSEISTSGSATSADLTSSDKTNRYPDSIKNLFTRAEKCHELICRAAMAKEDRNYDLELETKNSKDIIIKLDPNGKEEEMINKLTDGNRRLRRHMKIRQSVSDSKGVTTIPDEVSTLLQQLPKDMIYGRKLYDDITNSLMSTLPEPTETFLKKYEVPLSEIEHELRNRGLDV</sequence>
</entry>
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    <accession>A0AAJ8L5S5</accession>
    <name>A0AAJ8L5S5_9TREE</name>
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    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
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                <person name="Pearson M."/>
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                <person name="Roberts A."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="28">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="21">Forms DNA polymerase zeta with REV7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058824.1">
        <property type="nucleotide sequence ID" value="XM_070202723.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30170044"/>
    <dbReference type="KEGG" id="kpin:30170044"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05778">
        <property type="entry name" value="DNA_polB_zeta_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05534">
        <property type="entry name" value="POLBc_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000007">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000002">
        <property type="entry name" value="DNA polymerase zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000024">
        <property type="entry name" value="DNA polymerase zeta catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056435">
        <property type="entry name" value="DPOD/Z_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030559">
        <property type="entry name" value="PolZ_Rev3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025687">
        <property type="entry name" value="Znf-C4pol"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812:SF1">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24055">
        <property type="entry name" value="POL3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14260">
        <property type="entry name" value="zf-C4pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="22" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="18" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="17" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="15" id="KW-0408">Iron</keyword>
    <keyword evidence="16" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase delta/zeta catalytic subunit N-terminal" evidence="27">
        <location>
            <begin position="92"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="25">
        <location>
            <begin position="1120"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="24">
        <location>
            <begin position="1399"/>
            <end position="1845"/>
        </location>
    </feature>
    <feature type="domain" description="C4-type zinc-finger of DNA polymerase delta" evidence="26">
        <location>
            <begin position="1907"/>
            <end position="1979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="444"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="512"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="778"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="854"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="22">
        <location>
            <begin position="817"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="530"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="574"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="591"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="614"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="659"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="678"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="785"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="857"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="909"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="957"/>
            <end position="985"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00066055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF14260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF24055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="WWC69380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="2003" mass="225652" checksum="8BEDA48ABB82A7F3" modified="2024-07-24" version="1">MPYDPGGPSSPAYPSSHPYSEQPPAEPILKLRITHITSTLSAPLPSLREYYVPSRFSTAIPPGNLPDKLPVMRIFGTTPNLQKICANIHMCYPYFYVPFPMDSSSGDDPLRPERVIKICQRFAVSLNHAICIASRQNPTSIGNANKFGGGVDPKHLHVISVMLVKGIPFYGYHIGFSYFLKVSLSNPSKFWTALEQLRKPIVLGRIWQPHEAHMNHVLQFMCDFDLYGCGWLEVGGGKFREPLPEGDPYDSPPSSPHGIPEIFNSLTVPESMLYPFGMSPPKDTYTPLEIDILPHHILNRLRLKPRNLHQDFIELLHQPLDPNEKLVPAVAELWEDERRRRSLKGLSLGSDAMMPGSGGMGGRTMEELGYKVQGKDYSGQDENKGGNWKISGELWEFIKERMDDERRKKGKLSFTGFSNEIAQGKDGEKRIYDKWVMTTFQAVSAHWPRPPRPPKSTQKSRRSAKSNNLSSQMNPLSSPAAASIALASSPSGHEASSPTQAEIPLISTKGEEPNLMEDGIDQHERIGVTSEDEDEEEEEERNPFEQYAMTQASQHVPIDMDVNTRMISRHPSEADDENRETDDYPDDEDDNVKKHAEEGAKFRATQMPKKVAFEEGDGDDDEALFDDIDDEDITELLRQNFPAGGSNQSTPKKNRFANGSITSSTRSSATGSSSGDFSGRRTDRQKRMMEQAGLGDLDTIMDRSSVSIPSPRNPWDNRPVTPSKPKTPVSDKPTPTTLMRNLFAKNRHPSISPLNTPTKNRPALAYDSPNVIMLPPLRRTQGDISSSPPSASGSLPRDPEDTLAELSQMQRNVTSKLGISQDDLEDAKDELKEIEAELPDQDVVDAFFRPKQKTPISFSDSRSTKSSDGNGQFITPTFKGTKRPLSPTLKNDDDESEVTPKAMLLPSSVMRNPSIANGEPNSSVLKSRKRVRLATPPGASQQPLIPAKVTFTPIQKSTNSTNGTTTQSSQQSHPTSNSDSTSNNNVVLSSTSWQFHLAPPSKMEIMTTMEDSGIPSVIYQQPYYSNPIDVPARSKQFAGRVFTLKGNLVKDLQDFEGSFSDPLGNKRWLKSRRTGHKWKFGWEYAVTPPTAKEVIDWCEREDTALQADREKRLLLTSQLEKPTQKSKYGFKFSQKQKSKESEREQQNMSVLALEVFAESRHQLLPDPAKDAVTAVFYCYQNDDPTLEDNTKHKGYHTGYIILKDPKKTKSTSIEDETKGLNIQENIKCTVLDNELDLINFVIDLTKFWDPDVLAGWELHNSSWGYLVSRAHEEFAIDLMDQLSRVVSGHTGPKKDGYSAHHTSTFKVSGRHILNIWRICRSEINLNSYSFENVVFHLLHQRIPRYSSASLTALWRSKTPEHTHRVLKYYFQRVVIYMEIVDAAEIITKNAEFARVFGVDFASVMFRGSQYKVESFMFRIAKPESFVLVSPSKEQVGLQNAPFAVPLIAEPESKYYTHPILVLDFQSLYPSIMIAYNICFSTCLGRVEKFKGTNKFGFTELKVADGLLELLKDYLTVTPNGMIFVKPAVRKSLLAKMLGEILDTRVMVKHAMKGARSDKSLTSLLNARQLGLKLMANVTYGYTSATYSGRMPCIEVADSIVQTGRETLEKAQELIHARKDWGAQVVYGDTDSLFVALPGRSKEQAFKIGNDIADAVTALNPKPVKLKFEKVYMGSVLMAKKRYVGFKYEHPDDIEPVFDAKGIETIRRDGFPAQQKMEEVCLKMLFRTQDLSQIKDYCRQEWTKILQNRVSAQDFIIAKEVRLGSYSEKGVPPPGAAVAYRRMLKDPRDEPQYGERVPYIISNSDGKRLIERARTPEEILNNRTISIDSEYYIKNLLIPPLSRIFNLLGADVENWFDTMPRIKRLGKYENENENGIFHNSKKIINFKNNNNNNKKGMKIDNHFKSNHCIICGIESSETICLNCKKNKSNTIHTLLSRLQLSSKKLKELNLICSSCCNNNLIINGEKNLCNSIDCSILYSRINSERDLEDLKNVNDLIKELELDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L7G9</accession>
    <name>A0AAJ8L7G9_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_104948</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
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                <person name="Roberts A."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="6">CBS 10737</strain>
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    </reference>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <location>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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</entry>
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    <name>A0AAJ8LAA8_9TREE</name>
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        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
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    </gene>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Abouelleil A."/>
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                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
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                <person name="Roberts A."/>
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                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
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    </reference>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    <comment type="similarity">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LAE9</accession>
    <name>A0AAJ8LAE9_9TREE</name>
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        <recommendedName>
            <fullName evidence="12">Rho GTPase activator</fullName>
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    </gene>
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        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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            <taxon>Agaricomycotina</taxon>
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        </lineage>
    </organism>
    <reference evidence="10" key="1">
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
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                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
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                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
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                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <subcellularLocation>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="LIM1_Lrg1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09392">
        <property type="entry name" value="LIM2_Lrg1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000058">
        <property type="entry name" value="Rho GTPase activator Lrg11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215:SF10">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="290"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="352"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="9">
        <location>
            <begin position="1115"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="927"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1360"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="35"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="153"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="247"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1360"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1423"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1461"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1485"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1508"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1522"/>
            <end position="1542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC73154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1542" mass="169563" checksum="23897783915115B5" modified="2024-07-24" version="1">MSSPSQSRGMVPPPGSWSSTSRYQDNGDQSRRSIDQQQQPQASSSSSRNPSMNSIHNSPTSISSSSRHQIVGISNGSSRYNENGEGYSDSYNGYNQDNRRPLPRITTSNTDNEDDGSGRGPRSAPIRPMLDGINSFNGPGPLRSSSSPDPRTSNLSSSRHSSPSNSPIEHRGNFASSSSSSASGNQRNGNGNGHISPQPAVPSLGAPFLNASNIPTRSGSSNQNRDIGNMSTSDRERGINSKQSIHSLNDQSTSASTSSLSNQNDSQSGSGAQPSLVWPQPRTRREGGTTYCGQCGQSVHGQFVRAMSKVYHLNCFRCKDCNKVVAQKFFPVEDGDGMYPLCERDYFARLDLICAKCDQALRASYITACGNKYHVEHFTCSECDVLFGPNDSYYEHGGKVYCHYHYSTRFAVKCVGCETAILKQFVEMNRNGRDECWHPECYMISKFWNVRLASKTFNTPASSAVSSTISLLEMSSSTAPGAPVNSLTMQTIQPLTPSPNSEAGMTPGELKDRQEAMEMKVQQIWHVLSGYEESSAALIGDMLRAVNERRLLDIILLAERFILHVETLFAVIDDLEAQFAQTGAKGMAHAREAKQLCRKLVNLFSTMSQISPSGGPPPNNSELFTLITQLAHYLKILIRIALTGSIKLERDHGNTSAMTNCLARLNLLAIDNGDPTIKQRGEQLKRSIEALTRHPDGYISSTKDIAYGYRSLAPEITGETTLRGPQDENFIPPEGCAHCKTAIEEDCVRSGMFNRWHSACVICIICGETSLRPLPKDDNTTDDGSSHSHTDIVPTKIVKKSNLPARVDFFYCEPIQQIEQVPQSIYCGSHKTLGSINGFAAVSRLEQYAFLLHIALRRLYVHFRIHHDLPSVRDHGISDRSDHEVKRMKSVTLDRKLSSTARLPQRSMVVESPAGRMADANGQVVSARSTSDSNPQALTTNGPEINFPNSDSNNNIEMIDPDDPPSSATVDVLRPPFARNNTSVMIINENATTEDQEIDNLTMPNIVQEDDAITLGDIPMLANVTSRSTQPSALNSQSGGIGSLEGKLLLSNINPLQLVILKHFALLTLSKTGLGHLIDLDDVLELLEVRKNQWWNKIFKGTAKEKQKKKGIFGVPIEILVERTGSDSSQGASNTVLRVPEFIEDIISTMRQMDMAVEGIFRKNGNIRKLQQICDALDKDSTQVNLSDENAIQLAALLKRFLREMPDPLLTFRLHKLFCAAASLQNPDDRKRVLHLLVVLLPKYNRDTMEVLFVFLRWVASFSYKDEETGSRMDMANLATVICPSILYAKGANAAKDESFIGIQAVQELLENQDDFYLVPAELEFVLQENIYQIFAKELDLPPKEIHRHCSKYMSARAQALSSGLQPPQPQYAGTNNAKYSPSGNGPSLLPTSNSQSNIPTIGGGGQQREIRDRPSDPRLSVHASSSDPNTINSYSRTPIQSQQPVIASGGNGGSSRPNSWIQPNTRGNSQSSLNSPSHWEKPRGPFQSGGSRQSSRGSAPSSPGPGEEGRRSIGMDRERSWTPTHMNEGYTNGQHSYSQHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LAL6</accession>
    <name>A0AAJ8LAL6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Splicing factor 3B subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I206_106097</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the phosphatase 2A regulatory subunit A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059339.1">
        <property type="nucleotide sequence ID" value="XM_070203238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LAL6"/>
    <dbReference type="GeneID" id="30173290"/>
    <dbReference type="KEGG" id="kpin:30173290"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000039">
        <property type="entry name" value="Splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000088">
        <property type="entry name" value="Splicing factor 3b, subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015016">
        <property type="entry name" value="SF3b_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038737">
        <property type="entry name" value="SF3b_su1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12097">
        <property type="entry name" value="SPLICING FACTOR 3B, SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08920">
        <property type="entry name" value="SF3b1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Splicing factor 3B subunit 1" evidence="11">
        <location>
            <begin position="158"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="9">
        <location>
            <begin position="516"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat" evidence="12">
        <location>
            <begin position="929"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="37"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="69"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC72137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1151" mass="129194" checksum="046760836A6B64AF" modified="2024-07-24" version="1">MSEERPTLQTYTAPQDILDEHAELADQDDAPDVFEDNARSKQVAARQSDYHNRRFNRVDGQGEGEDERYEDRMRRINLQKEEERIRRHKEQMEKDKTEDEKMVLDDKTPPRALAGDDTPPRAIAGGDTPPRETTPPKKRRRWDVEEEVKQEPGVEAVAPKRKSRWDQTPSDTAPEIKKSRWDQTPAASAPTSVITSTPSIGGVMMVEDKRYRRMTDEELDGLLPGGEEGYEVVPVPHDYQPAPSVRKMVPAQTEHGFMMQDDSDAAKARSAAGGIQGSQEQTEIEGIGTLQFLKPEDTQYFAKVLGEGGGEDDDSSYTLEELKERKIMRLLLKIKNGTPPIRKTALRQITDRAREFGAGPLFDKILPLLMERTLEDQERHLLVKVIDRVLYKLDDLVRPYVHKILVVIEPLLIDEDYYARVEGREIISNLAKAAGLAHMISTMRPDIDHVDEYVRNTTARAFSVVASALGIPALLPFLRAVCRSKKSWQARHTGIRIIQQIAIMMGCAVLPHLRNLVDTVADGLQDEQQKVRTMTALSLAALAESAAPYGIESFDNVLKPLWLGIRQHRGKTLAAFLKAIGYIIPLMDPEYAGYYVRECMPILIREFQTSDEEMRRIVLQVIKQCASTEGVTPTYIKEEVLPEFFKAFWVRRMALDKRNYKQLVETTVELAQKAGVSEIVGRVCNDLKDESEPFRKMVMETVTKVIASIGAADVDERLEQLLIDGIIFAFQEQTLEDTIMLDGFATVVNALGDRVKPYLPQIVSMILWRLTNKSAKVRMLAADLTTRLAPIIKSSGEDNLLSKLGVVIFEQLGEEYPDALGSLIAAEGAIANVVGMTQMNPPVKDLREYRTKANIADNLVPRMTPILRNRHEKVQEATINLIGRIADRGAEFVPAKEWMRICFELLDLLKAHKKAIRRAAVNSFGYIAKAIGPQDVLSVLLTNLKVQERQSRVCSTVAIAIVSETCGPFTCIPAILNEYRTPELNVRNGCLKALAFVFEYVGEMSKDYIHSVVGLLEDALTDRDHVHRQTACAIVKHLAVGVAGLGYEEALTHLLNLVWPNIFETSPHVIGGVMDAIEAMRLGVGSGPVLSYVLQGLFHPARRVREVYWRMYNTLILGASDAMVPFYPNLGSAADLASGQDYTRHELMMWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LBP7</accession>
    <name>A0AAJ8LBP7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_106619</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059454.1">
        <property type="nucleotide sequence ID" value="XM_070203353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LBP7"/>
    <dbReference type="GeneID" id="30175859"/>
    <dbReference type="KEGG" id="kpin:30175859"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21037">
        <property type="entry name" value="MLKL_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059179">
        <property type="entry name" value="MLKL-like_MCAfunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF298">
        <property type="entry name" value="MIXED LINEAGE KINASE DOMAIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="416"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC72655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1087" mass="121234" checksum="E220D9C636313185" modified="2024-07-24" version="1">MPSSTSPKVTHNGSPSPSLIIQPSDPHQISFKSSGDPSSRPRLLLNGPISQDVFAASPVETVNITSSSPVIFHSPTDPYKTLAKHSRSFSGGRALPDVLDDPFGYSIAKLEKAIDRLDKIGEGVEFAGNVFSAVPLLQMGGGIILCLRQMLAVAQKAMENKLDTLGLVSDSITIVDAVKGRIRANATPPSEEMRAGIEALFQKLTSNTDLLEKFVGRSKFKLFLYAGKMQRQLGDARNDTLMYIARFTLESIVSLDQLQQEAQIQRQHDRKEFVGRLNTFIRDPQSARHLIENEEVPEILVTLQREVERHRSAISYSASLSPPSRRNKLRRQECSTTLSHPFDEDEEEELALSRQPTWEAHTSTTPSKRAWQTTTDELDIETSKGEFCHSFLKYLRGESQKVVEDLPVWTITEYEVYREQRECTSNFAKVWRGRWHDQEVAIKDLDPLTDRHLFLAEVNIWCRLNSEFVLPFYGASSAVGPPPWFLVSPWMKNGRITDYVRSERGRDVDRISLIHQIAQGMEYLHSRDVVHGDIKGQNILIDDKGHPRLCDFGLSQIKIDITNKSAIPPEEGDSAAGTLRFQAPERLKLGPLTKECDVHSFGMTIHQIYSGEIPFAALDMYNAKTSIIEGDRPPQLPDVPDHLYRLMTRCWNPDPQARPTFEEISADLSLMCESPYSPPRSTRSIPALLDLAEVEDLRSRPPSRLASPVEISATNINDLDVWFTPPLVASHSGGDINFSGLDPVVSDLGDELSIIEERDTPIYIPDQSGRAAPTEHDLERRYRRHFNYHDYPDRLNLPQWVPSDVSLGDVGYMKNGHFVLLVRAFDNMAAYGILGSITNKPRTIPITQSTVYPRLVGDVAKDYGVRIAAAFRSKKKSVTKSVMRQVTVPMCPGKKAVRLIVADGKFQMMKNYETLREYFAAEADSILQKAIEENHEGLQKTDLVAVVGTLTADNYAMAVSEYSPGTNIIFNIVSPCAKSSIEPWGFWTVARDRSPNVCATSTPDTTPGRNSDSNLIADLNPSIASRPIQPSPPGLPVILKRLPGVDDQPLQYSVKVSEPNGPKLAVHLSVLRFPSTGGEPTLLRDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LBV6</accession>
    <name>A0AAJ8LBV6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_106776</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070059498.1">
        <property type="nucleotide sequence ID" value="XM_070203397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8LBV6"/>
    <dbReference type="GeneID" id="30175705"/>
    <dbReference type="KEGG" id="kpin:30175705"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WWC72812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="788" mass="87122" checksum="C56E19F4B01BFAE6" modified="2024-07-24" version="1">MRTLSEIEREDIIGTYTAPTGLYELVKTTPNGISCWLMARTAAHLHGRFIRTCRWSFYSDWALFQTSDPKAANYISAEYEACPLLPGQLPSTVQALNVRFDQKGHERPFQKSIIVDIVDGFLNVGDKIHIRLGDRRMGGAGTRIQTFVEKDFRIRFYVDPVGTSRFAAVPGDVILQILSGPPASLVVLAPRLVKTSDKQIKVVIRAEDAWGNTVNNHTLSVTLSLINQSNGKVVQRRETCLPQQGWSTRTEMLSLGEEGSYRIQAVAQEYPSLSGSTLFTVKTDAPSVYYADLHVHSDDTVGTNDSLYNFSYAKECAGLDVVGYTANDFNITKENWNATVQLIDQLNTDNEFVIYPGTEWCGNTAVGGDHNVVFLDERHREFPYDRHGNVARSFEWNDQMQTDTIEPGTWPIDELYATYAHAPESHLLIPHIGGRRANLGWHHPQLERLIEVGSAWGHFEWFLRDAVARGYKLGVSANSDEHRGRCGGGVPGTAVFGTRGGLTGIIANRLDRPSIASALRARHTFATTGQRLVGLTWIDDNFAKGQGDEIVARSSKDLTQVGYRFFGQEAGFESIEAFGWNGTIMKRDLQEEVGYSEAHIRVSWGGARIKDRYREATWKGSVTVTNGIIRGVKRISVADTHPEETQWVNTDGSVGFTSSTSGDVDGIILDISWFGLESGEIHVQGTIEGYVGNALDPPPFKHCPTFSITGQRSGLYSSKPQLRKNLGGVDMFVAIERVSRPGQLPVEIDGVVDIAPKNGPHGFSPVCFVATQADGAKVWTSPIFVQFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LCX3</accession>
    <name>A0AAJ8LCX3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_106899</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NFYC/HAP5 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC72935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
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    <dbReference type="CDD" id="cd22908">
        <property type="entry name" value="HFD_NFYC-like"/>
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        <property type="entry name" value="Nuclear transcription factor Y subunit gamma"/>
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        <property type="entry name" value="Histone, subunit A"/>
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        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR10252:SF8">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="8">
        <location>
            <begin position="165"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="247"/>
            <end position="326"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="50"/>
            <end position="110"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="248"/>
            <end position="265"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="269"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="285"/>
            <end position="311"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00038129"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC72935.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="326" mass="36602" checksum="02187208782BFBBF" modified="2024-07-24" version="1">MNPSYFLPNQGGFPDGPGPSNYSNSSGSASRSNSNSSSPIEGILQGQGQGEYQNQNNNYQQNSKKENSNQNQMNNNNNNNINGNSKISTTSNNNNNNNNNNNNNNNNNNNTKPYLTQAEQRQALHPPLHGPMILPHQDLNSFLETFWKRQMDNVEGEIPDWKSYNLPLARIKKVMKSDEEVKMISAEAPIMFSKACEIFISELTCRAWLVAESHKRRTLQKSDVAAAIAFSDMFDFLIDIVPRDDGSNNDNNKNSNNNNENSLINDGGGGDEEEQMEEEGNSNYINNISIQQPQQPQQNSQIQIQTQNQNQDGDGDDLYNEYVQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8LEF1</accession>
    <name>A0AAJ8LEF1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">V-type proton ATPase catalytic subunit A</fullName>
            <ecNumber evidence="2">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">I206_107657</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_070203564.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="30174361"/>
    <dbReference type="KEGG" id="kpin:30174361"/>
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        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055082">
        <property type="term" value="P:intracellular chemical homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18111">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18119">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01134">
        <property type="entry name" value="V_A-ATPase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00309">
        <property type="entry name" value="ATP_synth_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
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    <dbReference type="InterPro" id="IPR031686">
        <property type="entry name" value="ATP-synth_a_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005725">
        <property type="entry name" value="ATPase_V1-cplx_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003220">
        <property type="entry name" value="PRK04192.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01042">
        <property type="entry name" value="V-ATPase_V1_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607:SF1">
        <property type="entry name" value="H(+)-TRANSPORTING TWO-SECTOR ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="V-TYPE PROTON ATPASE CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16886">
        <property type="entry name" value="ATP-synt_ab_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="14">
        <location>
            <begin position="23"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="ATPsynthase alpha/beta subunit barrel-sandwich" evidence="15">
        <location>
            <begin position="127"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="13">
        <location>
            <begin position="232"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="16">
        <location>
            <begin position="465"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="WWC73685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="594" mass="65734" checksum="672F12AB6CB29920" modified="2024-07-24" version="1">MDRAKRDLPKIRDEERERMFGSVYSVSGPVVIGENMRGCAMYELVRVGHDELVGEVIRIEADRATIQVYEETSGVTVGDPVLRTGKPLSVELGPGLMTNIYDGIQRPLKSIQEKSQSIYIPRGINTESLSREIKWDFNPSSFRVGDHLSGGDIFGSVYENSLVDNHKIMLPPRAMGTITRIAEKGSYTVEDVVLETEFQGKTTQHTMMQLWPVRAPRPVAQKETASYPLFTGQRVLDALFPCVQGGTTAIPGAFGCGKTVISQALSKFSNSDIIIYVGCGERGNEMAEVLADFPELTLERDGREEPIMKRTALVANTSNMPVAAREASIYTGITLSEYFRDQGNNVAMMADSTSRWAEALREISGRLAEMPADSGYPAYLGAKLASFYERAGKVTCLGNPVRQGTVSIVGAVSPPGGDFSDPVTSATLGIVQVFWGLSKALAQRKHFPSVDWNVSYSKYLKVLDPHYEKSNPGFIDLRSRAKEILQKEQDLAEIVQLVGKSALGESDKITLEVARMLKTSGMLKNFVAFYDNSQRAVETSDMTFAKVRDSAADVMYKLSQMKFESPNTQSEQDIQGKFDQLYNEIGETFRRMQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MN20</accession>
    <name>A0AAJ8MN20_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">STE3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">I206_101549</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 4 family.</text>
    </comment>
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        <property type="protein sequence ID" value="WWC67639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019008795.2">
        <property type="nucleotide sequence ID" value="XM_019158182.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MN20"/>
    <dbReference type="GeneID" id="30174848"/>
    <dbReference type="KEGG" id="kpin:30174848"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004933">
        <property type="term" value="F:mating-type a-factor pheromone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14966">
        <property type="entry name" value="7tmD_STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001546">
        <property type="entry name" value="GPCR_Pheromne_A_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001499">
        <property type="entry name" value="GPCR_STE3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097:SF1">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02076">
        <property type="entry name" value="STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00899">
        <property type="entry name" value="GPCRSTE3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00900">
        <property type="entry name" value="PHEROMONEAR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC67639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="381" mass="42891" checksum="DA1AC94882FBBEE2" modified="2024-07-24" version="1">MRHPDYPLWSFIAMLLVLLPSPWHLRARNVATLSLIFWLLLANIVTFVNSLMWADNFRDLSPVWCDISGRVLLLISYALPACSLAQMRRLEFVASTRRSIISAKDRKRRIIEELTICIVVPCVLGALFYVVQGHRYDIVENIGCIIPVYTSVPGIIMRYVVPGSIAVASLVFASLAIRWFLIRRLQFQTILAASDSSLSTSRYLRLVALAVTDSAILIAYTIYDSTPNSDAPLLPYQSWKAVHLNFDQFAQYPEELLGTVYPIFVANVYAPFLYSIIFFAFFGFGEEAISGYLTLASRFMSLLERIGFRRNTSAHRFDDQNFTLGSKIMPADGDAVSFGERPEDVATATEQQAKPDYRLGKTGYVNQLHDGVAVTVERSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MPT3</accession>
    <name>A0AAJ8MPT3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">I206_105372</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011617.2">
        <property type="nucleotide sequence ID" value="XM_019155463.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MPT3"/>
    <dbReference type="GeneID" id="30172088"/>
    <dbReference type="KEGG" id="kpin:30172088"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="WWC71416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="229" mass="26138" checksum="2B2E9987F6728733" modified="2024-07-24" version="1">MTFIHHTIERNQPLCRKDVENSLSLSVRIPSDLTKKKWILSLRNSEDKRWNKDSYYLDLPIFPFKRDGVVQTRLANAEKSLLPTIVPRFMERARTSILGLCDDDDDDDDTNSQVRRHRRGGYNIPKLANKVVVNSALISRITDDLENALARRRSSGETGRGSLNDLDFKASIETDGLVEDIHLGWTSEDRGLGSFFDTEHFPPRIRISDLVGAGSRRRRLDAASSQWSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MQD7</accession>
    <name>A0AAJ8MQD7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_103776</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC69833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007467.2">
        <property type="nucleotide sequence ID" value="XM_019159415.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MQD7"/>
    <dbReference type="GeneID" id="30176094"/>
    <dbReference type="KEGG" id="kpin:30176094"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042526570" evidence="2">
        <location>
            <begin position="20"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC69833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="436" mass="44933" checksum="6704B449CBC33DB4" modified="2024-07-24" version="1">MISNGLLFGLVGVLTFARAAPTREPPYFTLESAEATVYYDLTGQDACANTFGPNWSETTGNTGPNARPPACETTRAKTLSDMDLVTAIAFNDFLVDNDLLNWCGRIVNVYRPDGTPYTLESGPFFIWDGCGNCHNRSIIDLSSEALIGLQEHANGTSGCDNPQGLRVEVTNDYYWKLKDGGEVNENPTEADRGTGTFVGPIPTDTTHSGPNSDFPTATWAGSATGQSSAGSAITSVSSNTAMSVSTGLADTYASATTSQLSGGLNAAVPTTTESQHGASNGIYNNAGTFTTSMTNSVPASQTIAGSANTLVAGAKDFAEGADTGDSLDNQAASATSESVGSSGSITDSSNLANATDPVSSTNTENDGISGSNSSDQVGSQIPNSEECECDPGTYTCEGLELRICGNIQAGTTKVGWMPSGQCSNKCELSGGNILCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MRS1</accession>
    <name>A0AAJ8MRS1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mannose-1-phosphate guanylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_105452</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>alpha-D-mannose 1-phosphate + GTP + H(+) = GDP-alpha-D-mannose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="EC" id="2.7.7.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.13" evidence="3"/>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011542.2">
        <property type="nucleotide sequence ID" value="XM_019155388.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MRS1"/>
    <dbReference type="GeneID" id="30172011"/>
    <dbReference type="KEGG" id="kpin:30172011"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06428">
        <property type="entry name" value="M1P_guanylylT_A_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="5">
        <location>
            <begin position="5"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="6">
        <location>
            <begin position="281"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC71494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="402" mass="43733" checksum="7AE9B02FCC124933" modified="2024-07-24" version="1">MSVTKGVLLIGGPSKGTRMRPLTLDCPKPLLPIAGKPMIWHPLSAFAKVPGLTEVIIIGFYEDSVMSGFIKEVKREFPNIGISYLREYKALGTAGGLYHFRDSILRPPVPQNIFICNIDICSAFPFQELLQLHSSHRGVGTIMGVNVKKETAQKYGCIVTEPESSLMVHYVEKPDSWISNTVNGGVYLFDKSLFDEIRKAMDEKTARAAEDPLVKPDEILRLEQDVIAPLAAAKKMYVYECKDFWRQIKTAASAVTANSLYLARIQKTNPDFLAKSSPNVISPVYIDSSATIDPTAKIGPNVAIGPGVTVGAGVRVKDAIILEGTNLEQHSCVLNSIVGANCNVGAWARVDGKPEPETDVKGQISVTILATEVSLAPETLVRSCIVLPNKSLNRNSANEVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MRV2</accession>
    <name>A0AAJ8MRV2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_107563</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009247.2">
        <property type="nucleotide sequence ID" value="XM_019157607.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8MRV2"/>
    <dbReference type="GeneID" id="30174264"/>
    <dbReference type="KEGG" id="kpin:30174264"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17325">
        <property type="entry name" value="MFS_MdtG_SLC18_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF23">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="12"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC73591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="456" mass="50196" checksum="C04E5C59934C9982" modified="2024-07-24" version="1">MGIKWRSSTWYITTVVTYGAWTEAFVYMVGVPIIPFRLEDLGFTHFSTRSSWFLFSYCIAISIYTLPNAIFLDKRSWRRSPMIVATCAMQLSLLLLILVKQYWAMVLTRIIQGLSCTVIWSVGFALICENVDQKVVGRQLGIAFTGSHLGNVVGPAAGSGLYSAFGWKGPWILCMGVCSIELIARWLVIEKNTIVIHQSGEQTKHVKKQDGYTTTPIAAPSPISEMTDSQANEHRLVKEKSNQLSPFQVVIGLFSIPRSLTAISVNFGTGLVIGAIDPTLTLRLKDQWGKDSHFVGLVYLATIAPVLLTGVITGHLADKFGAEWIVPTTSLLAAPFCLLMILQNSLLGFIMSFGLMNFFINCALAPIGVEVSAVTRDNDGISELHQFAALNLAWAAPMAIGTVIGGQLYDRIGWTSVCWFCFACCLITVPATLAYTGDRPLLRRFLKRNSISRTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8MSD2</accession>
    <name>A0AAJ8MSD2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_106645</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="30175833"/>
    <dbReference type="KEGG" id="kpin:30175833"/>
    <dbReference type="Proteomes" id="UP000094020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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        <property type="entry name" value="Tudor"/>
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    <dbReference type="PANTHER" id="PTHR46297:SF2">
        <property type="entry name" value="TUDOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46297">
        <property type="entry name" value="ZINC FINGER CCCH-TYPE WITH G PATCH DOMAIN-CONTAINING PROTEIN"/>
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            <end position="138"/>
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            <begin position="50"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
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    </evidence>
    <sequence length="241" mass="26768" checksum="DCACF2ABED86DC40" modified="2024-07-24" version="1">MEAELSTYKDQLAYVNLQLESDPNNEGLKTLKTELVELIDLTQQAMGHPAASSTSAAQTSKDAVKVDKGKTKDKGEHYKAGMDCMAKYKDGKWYPAKINAVVGSSDSPQYTITFKGYTTSTNVPLSSLRPHDPNAPVPKPVEPIKRKQDDLTEKEKEKKKKKGEKWMESQKAKADEIKDKKNAWEKFGKKASKKGIHISGLEGKSAFRTPDNPFVGVTGSGRGVTEYERMGKHKFAQDKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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    <name>A0AAJ8MSL6_9TREE</name>
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            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">I206_106133</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
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                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
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                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
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        <reaction evidence="13">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
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            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
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    <dbReference type="EMBL" id="CP144526">
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    <dbReference type="KEGG" id="kpin:30173327"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="P:copper ion import"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
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    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
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        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
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            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
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    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
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            <end position="314"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="16">
        <location>
            <begin position="480"/>
            <end position="612"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="1013"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="444"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="746"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
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            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="827"/>
            <end position="846"/>
        </location>
    </feature>
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            <end position="926"/>
        </location>
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        <location>
            <begin position="933"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="969"/>
            <end position="978"/>
        </location>
    </feature>
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        <location>
            <begin position="1013"/>
            <end position="1028"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="WWC72173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1143" mass="127123" checksum="FFF2255364D44D8E" modified="2024-07-24" version="1">MTVTGVTTAEVAQGTYAPPFKYVTSYAQDPEVTGSITMTASSNAAYATAYLQAHMMSWPSYRYAYLLWFIFIALAGIYALAHHLRLSGGSIGLGYKKWGMKRKPIGRKIKGGSRGMSLPSNSSIISITIFTIISCVLTLIGSDYIIPTSSTLNFSTSFKRNIIEKRASIGYTISKSFWTSGSRFGFISFSLIPLVILFALKAPPIAVLAWKGFTHLYSDKLALFHKASAWLVWIFTTIHVILWTIQLFKDQTNGKAVWFLIWNSYRFIFGCVAYGAMTAVMVLSLKPFRKNSYEFFYICHVIFVFLTIVCSAIHHPVLWFWMAGALALWGLERIYRFFRLAKINGLFGKQKSRGGNNYDVLAGKPYQDKTQTYGMQDLKRSSEYDPVYTDKTLPQPPIHDHVNGQDEFGKSTNQGYYDEGSLQPLGSYEQRYDQPLPQHERTESTTNMMPIPRSQSGAIPRTSSMASMRMSSPALPSFVPVPIPIGYAQAQLLPSRTVRLTINVARPFTWSPGQSVLLYLPEISKFQSHPFTITNNDPNEIVLLVKARKGLTRRLFNLVRAKSLAAVGINDVKDKRISYQSLNPNDSKAALQVPPIFIKSWVDGPMGSSGRVNWTNYSTVLIICGGSGVSFGTAICDYVCRKMNNGIGRTRRVRFCWVVRAFAEIAWIASQLRRCQNLVPKDQLEISIFVTKGHKPLTSSRSTGGLSGGGDEFAPPRPGFAGGTHQRRGSADSIASQMSVDSDNEGASREYDETVDSHLSSNYADVIDLTNYEDEEDVNDPAENILSENLQKQGKVRRAKSRKAAKKTRPSYGGQAIPQTGSPLYPPNRQSQHQQQSSYDYPQPRQTSAYSGYDEYQQRSSISSFDDLQPPRRSGYDDAYGGVQHSQQGSSNLYAPQPNQYTSTQQSPTSAPMMLGNTSGSQSQSNYDRRQSYRSLADSTYNQYNPFNNGNGTGQYSMGPSPSPSIMNFGGGGGGGGDDISIAGESVRDLLSRTSRTQSMVLLEDPDYNDYFSQQKQQQHQEQEQSSEIDNNNGRRKSNFSNLNLNFKSTAEQEKDGGLWIDESDYVAMNILSENSVKGKPKLSIVIQEEINLNLGNMIVATCGPITLNTVIRNLISKNISPSKLRRGDKSGQIDIYSEDYET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HSC4</accession>
    <name>A0A1B9HSC4_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_07818</name>
        <name evidence="5" type="ORF">I206_100003</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700119">
        <property type="protein sequence ID" value="OCF46148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007367.1">
        <property type="nucleotide sequence ID" value="XM_019159503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HSC4"/>
    <dbReference type="GeneID" id="30176187"/>
    <dbReference type="KEGG" id="kpin:30176187"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF46148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC66103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="167" mass="17662" checksum="32A9D665FD93C8AE" modified="2016-11-02" version="1">MEQAQTAGGTSSRLTAVLEPPRRAQPEWGEVQLPPPDTGSSIRKNNKGHWLAHGLMTATLASAAGGIGYLAAKDGTSELRDCKTDNRTNWEKAKEVAEELQEAQESISYLKDEIDSLNSSASCTNSCNIASAASTLSTVQMQSDQATSTGNTIQISITPTPTAHDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HTI1</accession>
    <name>A0A1B9HTI1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">NEDD8-activating enzyme E1 catalytic subunit</fullName>
            <ecNumber evidence="8 11">6.2.1.64</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">I206_07430</name>
        <name evidence="14" type="ORF">I206_106681</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine = AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.64"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.64" evidence="8 11"/>
    <dbReference type="EMBL" id="KI894016">
        <property type="protein sequence ID" value="OCF46577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007796.1">
        <property type="nucleotide sequence ID" value="XM_019159124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HTI1"/>
    <dbReference type="STRING" id="1296096.A0A1B9HTI1"/>
    <dbReference type="GeneID" id="30175799"/>
    <dbReference type="KEGG" id="kpin:30175799"/>
    <dbReference type="OrthoDB" id="10255449at2759"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01488">
        <property type="entry name" value="Uba3_RUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.520:FF:000001">
        <property type="entry name" value="NEDD8-activating enzyme E1 catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000002">
        <property type="entry name" value="SUMO-activating enzyme subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.20:FF:000003">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014929">
        <property type="entry name" value="E2-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030468">
        <property type="entry name" value="Uba3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF6">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08825">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01181">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="E2 binding" evidence="12">
        <location>
            <begin position="357"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006310"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00015203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023624"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024626"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU368009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCF46577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WWC72717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="440" mass="48572" checksum="4F8BBA381217A423" modified="2016-11-02" version="1">MAAAVLNGVTNGIASSSKIDSYLADESRFASIDKVLDRRGPWTVEEFVGGEGTKDFLRKQSKVLVIGAGGLGCEILQNLALTGFNDIHVIDMDTIDISNLNRQFLFRESDVGKSKAIVAAEFVMNRVPGVKVTPYHGKIQDHPTTFYQQFNIVVAGLDSISARRWINATLVQMAEEDEEQLKPLIDGGTEGFKGQARVILPTVTSCYECSIDMLTPPTAFPICTIANTPRLPEHCIEWASVLEWPKVHKEKKLDTDDPDHIEWLYQQASARAAQFKIEGVTWALTQGVVKNIIPAIASTNAIIAASCCNEALKIATAAAPYLNNYMMYVGNESVYTYTFEHEKRPECPVCGGESLIAEAKRDWTLERFIESLINRQDLQISKPSLSYSRGALFWPSPPDVYTATRPNLEKPLVDLLGEDEGIVVTDPALPVSVNISIKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HTK5</accession>
    <name>A0A1B9HTK5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP synthase mitochondrial F1 complex assembly factor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_07450</name>
        <name evidence="7" type="ORF">I206_106659</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894016">
        <property type="protein sequence ID" value="OCF46597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144527">
        <property type="protein sequence ID" value="WWC72695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019007816.1">
        <property type="nucleotide sequence ID" value="XM_019159144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HTK5"/>
    <dbReference type="STRING" id="1296096.A0A1B9HTK5"/>
    <dbReference type="GeneID" id="30175819"/>
    <dbReference type="KEGG" id="kpin:30175819"/>
    <dbReference type="OrthoDB" id="5673at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3580.10">
        <property type="entry name" value="ATP12 ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2180.10">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011419">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042272">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023335">
        <property type="entry name" value="ATP12_ortho_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013:SF10">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2/ATP12 PROTEIN, MITOCHONDRIAL PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07542">
        <property type="entry name" value="ATP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160909">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCF46597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC72695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="310" mass="34906" checksum="4219535D6578B960" modified="2016-11-02" version="1">MASVVRSFRPIISQQRGFLTPKITPISHSLIAGPSVNSSRYSSELNKRSYTSTKVIRATVQDGPPLTHTNRAEVTLRRFWKTVHIKENESGEYQITLDHRALKTPGGSKLIIPTERRLIALLIANEWENQDEVLKQHALPVTSLVSRAIDGLGEGEIRIGVINQLMKYLDTDTILFKNDTPSSLVRMQNEHWDPLYKWLENEYNVKLNSAKGFSPPKQSEQVKNKLKILLEGMDGWELSAFERAAYASKSFIIALALCKGKLTANQAADASHVEVRSQIEKWGEVEDTHDVDYQDIRRSLGSVACLLIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HUM2</accession>
    <name>A0A1B9HUM2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_06732</name>
        <name evidence="8" type="ORF">I206_102173</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Abouelleil A."/>
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                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Murphy C."/>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
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                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">CBS 10737</strain>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
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                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
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                <person name="Imamovic A."/>
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                <person name="Nusbaum C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
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            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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                <person name="Chen Y."/>
                <person name="Heitman J."/>
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                <person name="Young S.K."/>
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                <person name="Litvintseva A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="David-Palma M."/>
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                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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                <person name="Litvintseva A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="Dromer F."/>
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                <person name="David-Palma M."/>
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                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Asn) + L-asparagine + ATP = L-asparaginyl-tRNA(Asn) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9659"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="3"/>
    <dbReference type="EMBL" id="KI894014">
        <property type="protein sequence ID" value="OCF47921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009140.1">
        <property type="nucleotide sequence ID" value="XM_019157500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HXE1"/>
    <dbReference type="STRING" id="1296096.A0A1B9HXE1"/>
    <dbReference type="GeneID" id="30174154"/>
    <dbReference type="KEGG" id="kpin:30174154"/>
    <dbReference type="OrthoDB" id="1931232at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04323">
        <property type="entry name" value="AsnRS_cyto_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1910.20">
        <property type="entry name" value="asparaginyl-tRNA synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048952">
        <property type="entry name" value="AsnRS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF16">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20917">
        <property type="entry name" value="AsnRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="303"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCF47921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WWC73486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="606" mass="68013" checksum="EADA881C7113D4FE" modified="2016-11-02" version="1">MAENAQPTIAQQAQDVASKLATSVADTLNFADKPKEDADKSGLPILYIDEKAGSDTEGTGAELSPFATSLAAYQSLKPSPESDANPTSIVNLLIRKPDSVERNEWVEISTSAKKKLVKNISGWRKTEAKALAEGEKLQKEKAAQEEKDRKRREEAKSVVLVDDETKESKKTKIFAVPELVGSRVRINGWVHRFRPQKTNYFLVVRDGTAMLQCILSGDCIKTLDALDLTTESTVELVGTVEKVKEGQTAPGGVELIVDYWKIIGKAPGGADAFEGRLTKETDASIRADLRHLELRGETATSVMRVRALLLRAFRDSFYKRRITEVTPPCMVQTSVEGGSTLFEFDYYGAPAYLTQSSQLYLETVLPSLGDVYCIQESFRAEKSLTRRHLSEYTHLEAELVFIQFKDLLDHLEDMICEVVDTLLADPVSSEIIKTLNPDFQPPSRPFMRMDYRDAITYLNEHGIKKEDGSDHIVGDDIAEAAERKMTDQINRPIMLIHFPKLLKAFYMQPLASAPDFTESVDVLMPNVGEVVGGSMRITDYDTLMAAYKREGIPSDPYYWFTDQRKYGTTEHGGYGLGVERFLAWLLNRWTVRECSLYPRWMGRATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HXI6</accession>
    <name>A0A1B9HXI6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_05861</name>
        <name evidence="5" type="ORF">I206_107533</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894014">
        <property type="protein sequence ID" value="OCF47995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009214.1">
        <property type="nucleotide sequence ID" value="XM_019157574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HXI6"/>
    <dbReference type="STRING" id="1296096.A0A1B9HXI6"/>
    <dbReference type="GeneID" id="30174230"/>
    <dbReference type="KEGG" id="kpin:30174230"/>
    <dbReference type="OrthoDB" id="2565066at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
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                <person name="Heitman J."/>
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                <person name="Imamovic A."/>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="Zeng Q."/>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
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                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
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                <person name="Dewar J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
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                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
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                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="Zeng Q."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="GAL4"/>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF19">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
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    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="151"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="266"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="316"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1032"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="34"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
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            <begin position="80"/>
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            <begin position="107"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
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            <begin position="324"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
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            <begin position="337"/>
            <end position="351"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
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            <begin position="1039"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50048"/>
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    </evidence>
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            <dbReference type="EMBL" id="OCF48076.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC73638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1068" mass="116424" checksum="639618BB5751D285" modified="2016-11-02" version="1">MKRNWEGSSYGGGSNNQQSNGMPDGQDENGGWVQMSSHPYAQAYSSMPNPFQPSPLHNSTTYSDQHNSGYMDNGLNHGHVHQDKKAKNVDMRNDSIISGGSPKDGLSDDDDDDEDDDDDDNDGAKTTPAGKGKGKGKGDKPKVKLTRGSRACIACRKIKMRCIPDEGAGPGAPCKRCKSGGHECIFEESNRGKRSTRKNEAMAAKMAKFEAALKGIGAALSNLDQPALNSFSTALHGSTGDTDIINLITSHTSPSAVPTLAVAMNRQPYNTGGDGFSGEDAQHGQHHSQPPLSPRLHSLPDNVLSPLGLLAEASLQNTNDTSNKKSKSKSNYHHSHNSNNQQGGNNNSQNKNLHRTSALSYDGRSNPPPRSGSPLGMSPGGSYRLATSDIRGGNNAQEDEEPHMFNDNGQGVASHNYFKLAGTFNPAAGMSDTRLPELMTIVSRDEIGELFETFFDNMAFHVPLVYREFHTPDLVLQRSQFLCTVICALAARYYHKRPELHAQLSAYAKRLAFEVPSRGYKSVEVVQAYLLLSLWTLGPEKTFEQDRTWLMLGMAIRMATDLNLHRKSIVSGLDTEEGKARDLEIINRERCWLHCFVLDRSLSAQMGKPYTLREDYIIRNACEASWHQQRFSLPSDRPLSAYVVLQQIMSRAIDSIYSSTTTVSGLRHDCDYMLIVRSAHEELRRWLTEWNRPEQYVGIAGLADGRAEYDSRAQFYFAYSSLVLYSFGLENALERAKMDISFFLTNVYEAATRVCTVVKEEFLPKGYLPYLPDTNFVMCSYALLSLLKLLKPELRPYHDSEEAIFKLVSEMADILEDCAVDPAHQPAIYAAFIREIVRKTRELRHGPGTAPTSPGTLLSQQIHGTMATGHPIAIAPIAGTVGTDHSTAVAAAVAAAAAAQQANNAAQGVYDPQLMGEHANWQPGDLLPGHSGETQFTFIPQGGDMMILPSQAGPSIAPSPTAAFLANPLNSSSSNNTLTGNYVSTPTGNSNGWAEYLPTFMSSDGFDGWDGSMLLPGFGRNQITLGGGLLHSQHGSGIITPSHQTPSHSRMGSRAGSRAQTPHHGSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HXZ0</accession>
    <name>A0A1B9HXZ0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nuclear membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_06013</name>
        <name evidence="5" type="ORF">I206_107678</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894014">
        <property type="protein sequence ID" value="OCF48145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009364.1">
        <property type="nucleotide sequence ID" value="XM_019157724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HXZ0"/>
    <dbReference type="GeneID" id="30174382"/>
    <dbReference type="KEGG" id="kpin:30174382"/>
    <dbReference type="OrthoDB" id="5961at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040202">
        <property type="entry name" value="Brl1/Brr6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018767">
        <property type="entry name" value="Brl1/Brr6_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28136:SF1">
        <property type="entry name" value="NUCLEUS EXPORT PROTEIN BRL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28136">
        <property type="entry name" value="NUCLEUS EXPORT PROTEIN BRR6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10104">
        <property type="entry name" value="Brr6_like_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01042">
        <property type="entry name" value="Brr6_like_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Brl1/Brr6" evidence="3">
        <location>
            <begin position="229"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF48145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC73706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="432" mass="48581" checksum="3839A3376086D66D" modified="2016-11-02" version="1">MDEDSFTYEPRDKSGPMDIDSSYDTSRLDAFNLVGTSSSQDGHARKRFHSELDRAIPFNPNHTSGFAHFTNPSSNSAPLLLAALNTPKKAPSYDPSQWYNTAPRTPAAASLATVDDIDMDSPARGLATPVKPAETPSKGTEAKVEDEKENEEDNDKELKDEQPRKFAKGAVTRTNRKREKAKKQQQRSEDGISIRHSDSSTPTYSKSEHHYNVHMTPPALRHSEIPALLLGYLQFGVNASIVLFCLYLGVQFVLTVRRDVKDKMQEHSVEILQEIAECTNLYLTNRCDPALRVPAMEAPCKAWDACMNRDPTMVGRINIIAETFAGVINSFVDPISWKTMSFTLVTLSFLIILTNSALFNLRAKASHQEVPSSNNSFWPPQSQFMPQLPPHIPHPQQHMLPPQQHNYHAVDDRQENARQIGWTGEAKKKSWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HYG1</accession>
    <name>A0A1B9HYG1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_06174</name>
        <name evidence="3" type="ORF">I206_107842</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894014">
        <property type="protein sequence ID" value="OCF48306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_019157885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HYG1"/>
    <dbReference type="STRING" id="1296096.A0A1B9HYG1"/>
    <dbReference type="GeneID" id="30174543"/>
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        <property type="component" value="Chromosome 11"/>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="Epimerase_deHydtase"/>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF48306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC73870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="334" mass="36317" checksum="F555E38B11E3B58F" modified="2016-11-02" version="1">MSSDLQILILGASGYIGGTVLTDLLKQYKTSQITTLIRDEAKQAILEPLGVKTVIGNVEDATFLQDLAKNYDAIFNFAVPFAGGDESIKALVDGLEHRAKVVQSELKPILLQTSGTGSIMYGKNGEAGKEVWKDSDHERWEALPDSAFFHSGDRIVARAAARGIISAYIVMSPTVYGPGTGPGNKLSLQIPAYVKYAKRTGQAAYIGKGENIWGNVHVQDLSDLYLLLLQNAITYPSKTQATPESKGWSNLIYAGLEQHTWGPIITLVGDLLYDRGDIPKSGAKSIEEGQGDLYMFGTNSFMEISEKAKNLGWSRKQPTFEDAIQLALKPKSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HYJ6</accession>
    <name>A0A1B9HYJ6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_06189</name>
        <name evidence="7" type="ORF">I206_107858</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894014">
        <property type="protein sequence ID" value="OCF48321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144529">
        <property type="protein sequence ID" value="WWC73886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009540.1">
        <property type="nucleotide sequence ID" value="XM_019157900.1"/>
    </dbReference>
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    <dbReference type="STRING" id="1296096.A0A1B9HYJ6"/>
    <dbReference type="GeneID" id="30174558"/>
    <dbReference type="KEGG" id="kpin:30174558"/>
    <dbReference type="OrthoDB" id="2915840at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="FMOXYGENASE"/>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCF48321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC73886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="503" mass="56063" checksum="42599CD368360C00" modified="2016-11-02" version="1">MHIAIVGAGYSGLATASTLLSFGHSVVVFDSSPDVGGVWSSTNHYPGLKAQNDKDTYCFSTLPMPKDYPIHPDGQQVQAYLEMYVKMKSLDKEGRLRLKTRVMKAEKRDEGWILEVQSSQSTQLLSLDYLICATGVFSQPFIPTFNGSTIFTQAGGIITHTSSFHRLVDVKDKNVIVLGFGKSACDTAVAATNSAQSVTIVARDIIWKLPTYLGGVVHYSYLLLTRFGESLFPYNRPWKSQRFLNYGPGKLFREFVLAVVGLIITIQLKLVRFNLVPKKPFDTIARSSISLATPGLVSALSSGRVQVESYASILSLSNSKALLSNGKEIPADVIICGTGWTHHVPAFLPVEYSQKLLDENGDWILYRHVFPIDIPDLAFVGFNSSVFCPLTSEITAMWLASHIESDIALIRDFPSEIVQKRLTKEETAWHRRRTEGHHANGTSIVPFSLSNIDEMLEDLGVKIGWLSHIKEWILPVKPLAYRHILPEVLRRRGTLQAEKKKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HYQ7</accession>
    <name>A0A1B9HYQ7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Inositol oxygenase</fullName>
            <ecNumber evidence="4 14">1.13.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 14">Myo-inositol oxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I206_05192</name>
        <name evidence="16" type="ORF">I206_107263</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>myo-inositol + O2 = D-glucuronate + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23696"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="EC" id="1.13.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="13 14">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Polyol metabolism; myo-inositol degradation into D-glucuronate; D-glucuronate from myo-inositol: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the myo-inositol oxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.99.1" evidence="4 14"/>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC73296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009634.1">
        <property type="nucleotide sequence ID" value="XM_019156916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HYQ7"/>
    <dbReference type="STRING" id="1296096.A0A1B9HYQ7"/>
    <dbReference type="GeneID" id="30173561"/>
    <dbReference type="KEGG" id="kpin:30173561"/>
    <dbReference type="OrthoDB" id="5151075at2759"/>
    <dbReference type="UniPathway" id="UPA00111">
        <property type="reaction ID" value="UER00527"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050113">
        <property type="term" value="F:inositol oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007828">
        <property type="entry name" value="Inositol_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588:SF0">
        <property type="entry name" value="INOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588">
        <property type="entry name" value="MYOINOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05153">
        <property type="entry name" value="MIOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="131"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="187"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="265"/>
            <end position="266"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00029668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR607828-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR607828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCF48415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="WWC73296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="332" mass="38920" checksum="4747D367EBCDB09A" modified="2016-11-02" version="1">MVQAPEVTEYLKNKAKTLDEISDQIDEVNLLNLKKSHIKQLKEQGKNDIEIQKALEEEFDFDGESKFDSEKDKTGFRQYENACDRVKNFYDEQHTKQTLEYNLRIRKEFKETVRARMGVWEALELLNTLIDESDPDTTVPQIIHALQAAEAARKDGKPEWMQLTCLIHDLGKLLCFFGADGQWDVVGDTFIVGCKYSEEIIYGSKSFKKNPDYYNKELQTENGIYKPNCGLENVMISFGHDEYLYHICKTQSKLPKEGLWMIRYHSFYPWHRAGSNAYRNFMVEEDEQALKAVRAFNPYDLYSKSDAPPVVEDLKEYYQGLIKKYFPDELEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HYS7</accession>
    <name>A0A1B9HYS7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_05165</name>
        <name evidence="10" type="ORF">I206_107291</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC73324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009607.1">
        <property type="nucleotide sequence ID" value="XM_019156889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HYS7"/>
    <dbReference type="STRING" id="1296096.A0A1B9HYS7"/>
    <dbReference type="GeneID" id="30173534"/>
    <dbReference type="KEGG" id="kpin:30173534"/>
    <dbReference type="OrthoDB" id="8907274at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03390">
        <property type="entry name" value="PAP2_containing_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000017">
        <property type="entry name" value="Diacylglycerol pyrophosphate phosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF35">
        <property type="entry name" value="RE23632P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="8">
        <location>
            <begin position="110"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="339"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="343"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCF48388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC73324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="379" mass="42498" checksum="D08CE9628F00287D" modified="2016-11-02" version="1">MPLPWQKSHTSSSGGRVTTSNKSRRLRIFLSYAPDWALTIVLWGIFYLLDKINGYRRLFDITDNSLAHPYADPERVPVWLLAVLCGVVPAVIIIITAAIRRSFWDAQSALLGLILGLGLVATFTNIVKITVGRPRPDLFARCILPENLIENPLHSLTSWTVCTQSDDSMLKEGFRSFPSGHSSFAWSGMWYLILYLAAKMRINNRSGYTYKSWLLLAPLSCATLITISRTMDYRHHSTDVIAGSLIGIIGAWYSYRQYYPPIGSSQSYKPYSPRIPKDEEIPLHNRPIRSSMEGILNIQNESHHHTSGSSGDTVNGQQPIGMVNGGFESYEANRRDNWRAADSSKTQNNIVSSKNGKIGTEHDYGEGEETIQRSVDRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HYX3</accession>
    <name>A0A1B9HYX3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I206_05219</name>
        <name evidence="17" type="ORF">I206_107236</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC73270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009660.1">
        <property type="nucleotide sequence ID" value="XM_019156942.1"/>
    </dbReference>
    <dbReference type="STRING" id="1296096.A0A1B9HYX3"/>
    <dbReference type="GeneID" id="30173588"/>
    <dbReference type="KEGG" id="kpin:30173588"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16702">
        <property type="entry name" value="RING_CH-C4HC3_MARCH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000287">
        <property type="entry name" value="RING finger membrane protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056521">
        <property type="entry name" value="MARCHF6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCHF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145">
        <property type="entry name" value="SSM4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23113">
        <property type="entry name" value="MARCHF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="639"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="804"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="844"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="887"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="958"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="999"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1163"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1203"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1248"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1292"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1349"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1386"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="15">
        <location>
            <begin position="11"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="406"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="541"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1434"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="441"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="482"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="562"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1442"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1455"/>
            <end position="1478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OCF48441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="WWC73270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1492" mass="167037" checksum="99565A8363835A3E" modified="2016-11-02" version="1">MADFIPPTPQHNEDEGDVCRVCRVEGDEADPLIYPCKCAGSVRFVHPDCLKQWLAQTGKKHCEICGHKYAFTKIYPDQLPESIPITVYIRQTLLWLYRQQLWVARCILVVVTWLIVLPSINMFSLRSLLWIADHIGYTESSTPENSFTGNTTDISLSNATDLLNATVESNDTVSNGTRGLTVGDITDRPISTLFGIFKRAIERWMKGDENSAISFVLRGQILSISLAAVLIGLILLREWITQHNWQEGARPQIVEQGDIIPEEWMIVNGIARRTTDVMAALLGKARADRQNSELNRGQRGNLPDSREERLEIKEQKEEAALRRAQNQEEEAKKEQAGEVRKNDSFGLLAELKAGDDEQKKRLKTVATGLQEYVRSHQLAEQALKSTREEDVKAGEAFDQLMDQALAGRRPIQLPSAHGHFKEEEDGDAGPSRSRPDTNASDESRHPIKENDDFEKSLKERDEVAYKAPELLKKGKDREYRGETSQAGSNTGPAAEGDIPLFLPPSPTRTVSSASSPSNNVFRAGDTILFDERGNLIHDLPRAASPDQPVMPPRLPTPHDAENTDGGEDDRDWEDEPEAEIREIIENEMPPLGPGPGLEIRPVQVDFLEEEEEPWDRDDWNGILEVVGLMGPLHGLFQNVLFGVIIMSAAISIFVGLPLLIGKLFLSTDIIRTILSTARRTLHLIRKVTDPLVDIVFEIFKEVVALPVISSLRAVETILARKMGLGDPSSSNQRDILSRLFDILSLSASSSSPTAGALTGQHQGRYAGLFGDALAWLGQTAYDTYAAYVAGKRKISIGNTVSNRMFTVFSGYGVAAAIVGLIALPGENGGSISKELSKIVKDHAMFLKLAFFMILELGAFPLGIGLMIDGCTVPLWPGATILGRVAKLRASPFGVMFLDWLIGTMFMYQFATLLSHIRTLCRPGTLFFIRDPADPNYSPVKDIVEKSALSQLRKLWTSAVMYSVIVFTLFGASCWSLAYMPFVNLLPLKLNPTFGPLTSIPFDLLFLHLVVPPTVTYIRPRYRASKLMNIWWKHTISLFRLNTLMARRNTTSDHSTLDTRPNKLEKVWPILDPVYQVLFGKYNNESTKSRVPASDQVILLPPAQRKAEGGVFISLNENGVPFTPEDKLRLLKQDRRAREASRDPIRDYEVIHLPQYWRTRVHTFIGTTLVTSALVLAFGAFGPIVTGRLASGLLGGSRSVHDGYNWLFGAYIIYLSFLLGRSARRHIMTLSRAARIRRSARSTRIKRTLIKYLTGTYGLVTIYGVIPFFVGLLGDIYGSTFSWTRRDSAGGRIVVHFWDTWSIGIVICSLGVGLMSNLNKLKPTRGSLLDKLKVQFKKPFKEDLITTHKVVLPAIGCLLLVNLSPFAITSLVALITKGKYDDVVYQALLQAIIPLLFRIFIIIGIKQYLNTGWQDMRQSMIDAEYVVEERVENYDPSKEEQKQKKKNEKKKKGVILEEEEEEIEEDWEDENDNDLEEDEGEVNIIRDDVLVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HZ80</accession>
    <name>A0A1B9HZ80_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin cytoskeleton-regulatory complex protein SLA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">I206_05361</name>
        <name evidence="19" type="ORF">I206_107095</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SLA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC73129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009801.1">
        <property type="nucleotide sequence ID" value="XM_019157083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HZ80"/>
    <dbReference type="STRING" id="1296096.A0A1B9HZ80"/>
    <dbReference type="GeneID" id="30173730"/>
    <dbReference type="KEGG" id="kpin:30173730"/>
    <dbReference type="OrthoDB" id="5971719at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11773">
        <property type="entry name" value="SH3_Sla1p_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.700">
        <property type="entry name" value="SLA1 homology domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013182">
        <property type="entry name" value="DUF1720"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056996">
        <property type="entry name" value="PH_SLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007131">
        <property type="entry name" value="SHD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035800">
        <property type="entry name" value="Sla1_SH3_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735">
        <property type="entry name" value="FCH AND DOUBLE SH3 DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735:SF21">
        <property type="entry name" value="PROTEIN NERVOUS WRECK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08226">
        <property type="entry name" value="DUF1720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24081">
        <property type="entry name" value="PH_SLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03983">
        <property type="entry name" value="SHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="17">
        <location>
            <begin position="2"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="17">
        <location>
            <begin position="313"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="272"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="374"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="441"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="565"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="725"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="783"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="878"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1140"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="135"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="382"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="442"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="565"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="593"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="787"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="829"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="843"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="878"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="912"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="924"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="940"/>
            <end position="949"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OCF48582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="WWC73129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1160" mass="126589" checksum="A851BA7976F83609" modified="2016-11-02" version="1">MAYVAVAKALYDYDAQDPETEISFKEDQIFYIIEKEDDDWWKAKAKDDEGDAEGSVGLLPASYVEEIPPVNTTRALFAYESTSPEELSMGDESTLHVYSIEEDWLLVKIEGGDERLGFVPRNYCEPMDASAELEVEDAADAAAEIEAARQAEKEKEIAEKQRQLKLKDKVETWSISELDGKKKKKGTLGVGNAAVFFASDTDKSAPVRQFPISDLISVAQPSSKTLDLTFATLGQPLHFHCGGSDTTKAILAKLETSKAAAGEALEMINEARGGYSSAEEETLPPPTRNVPPSSAAEPRGVRFAPETAPASSASAETATVQYDFDADGDDELTVKDGETVTIVDKENDEWWLVRNLRGKEGVVPAAYVQLNDGSAQQNGAAVEEHDSEDEREREAEAAAQLDAERKRQAQAAAEERRRIQVAAEARRAQEEEDRQLAEAIQEEQREKAARKALKRQEEERRQREANAETARERARSGGMQPPKITKRPSNNDVAAAAEKIPTRGHAAPARPPENNRPKPNPNRIRTWSDKSGQFNVEAEYLGLNGNKIRLHKVNGVIIEVPMDKMSSRDSELIRRHEAKKRAASMDDDDVPLGQSSRRNGNSTPPVRSTESQRRAAPAEEPIPPEAMAMPKPRKPRFDWFEFFLSAGCDMDDCTRYASNFERDRIDESILPELESSTLRTLGLKEGDVIRVRKAIQNRFAKKTPEQQAQIDQDMEYARQLQEFENSGRKGTAPQPPPGLFTGPGGKLSNNTRRGRPEKKSSGIESVDPSALAAASDQLAKTFISTPPQAPTPPPMAVSPPPVEEKKPAPLIAGFDDDAWTIKPTSKPASPAPSAPPAPPAPPIFQTTPAPALTAAPTGPANNTDSLLAQINALRPASTGISANDTGGSGSFDTVSKMVGQPRPPAQNYGLGMQNTGQPMSQLYGQQTGFQPQQQQQSPQPTGPRGPLAPVPANAGLLNPMQPNMTGMFVPTRGMSPMTAQQTGFSPQQQPQQQMMAQPTGYQAGFQQGYGGQQQQLGIQPNFTGYPGGMGMGMQQPQMQQQSSFNAIANMPPPQQAQGDQNKFAPSNIFAAMKKNDFGKPEEQQPQSSNKYDALRPLTTGYNGAPGQMMPQQTGYGMGMMPQQTGYNMGMMPNMTGYNPMMGNGYQQQQQNQGQNPYGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HZ81</accession>
    <name>A0A1B9HZ81_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glyoxal oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">I206_05364</name>
        <name evidence="7" type="ORF">I206_107092</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC73126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019009804.1">
        <property type="nucleotide sequence ID" value="XM_019157086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HZ81"/>
    <dbReference type="STRING" id="1296096.A0A1B9HZ81"/>
    <dbReference type="GeneID" id="30173733"/>
    <dbReference type="KEGG" id="kpin:30173733"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009880">
        <property type="entry name" value="Glyoxal_oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208:SF96">
        <property type="entry name" value="GLYOXAL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07250">
        <property type="entry name" value="Glyoxal_oxid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="GO-like_E_set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628215" evidence="3">
        <location>
            <begin position="27"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="617"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="Glyoxal oxidase N-terminal" evidence="4">
        <location>
            <begin position="136"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose oxidase-like Early set" evidence="5">
        <location>
            <begin position="461"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OCF48585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="WWC73126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="641" mass="70224" checksum="14BB7F36A11E6500" modified="2016-11-02" version="1">MPLSSSTFLHVLSLTALSIAPLTVQAQTPNTFKYVGLSGVSAQQLFLGTLNKVYIVDKTENNNATVNGHPAWATEYDLTTNEFRTMDVLSNSFCAGGTVLGNGTWLNVGGNQAITYGGTAMPNTQQSGQSPYKDWDGGKAIRLIDPCDDESCEWVDNPAMYMTSRRWYPTLETLEDGSAMIMGGCEWGGYVNYADNQNNPTVEYFPSKGTPFTLQFLLKTMPVNLFPLIWLLPSGNMLVQAEFQAEIFDYKNNIEYPIADIPDCVRVYPASAGTAVFPMTPENNWTATIIFCGGTFLEADQWTTTWAINTYPANQSCVKITPDVDLNWYHEDPLDTGRSMGNFINLPDGRLFYVNGAHLGTAGYGPEDWTIGQSYADQPLYQSWYFDPKAAAGSKWSKAAVSPIPRMYHSVASLLPDGSVIVSGSNPNADYVNKEQNTTYTYFTQYQVEIFYPDYWGKTKPNPTGMPTQLTYGGDPFDIQLTLADLDNSAININKTRAVIIRTGFSTHTMNMGQRHVELDTSFTTQDDGGAILHVAQVEPNPAILVPGPALFFIVVNGVPSNASWVTIGDGIIGQQTIKPRSVLPRSQISAQLMAQYGGYTGRSSYTVNSSAGHMTITTSTAMLGMMVLFMGLGLTSLRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9HZY0</accession>
    <name>A0A1B9HZY0_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MIF4G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_05624</name>
        <name evidence="6" type="ORF">I206_106831</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI894013">
        <property type="protein sequence ID" value="OCF48843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144528">
        <property type="protein sequence ID" value="WWC72867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010062.1">
        <property type="nucleotide sequence ID" value="XM_019157344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9HZY0"/>
    <dbReference type="STRING" id="1296096.A0A1B9HZY0"/>
    <dbReference type="GeneID" id="30173993"/>
    <dbReference type="KEGG" id="kpin:30173993"/>
    <dbReference type="OrthoDB" id="27832at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000037">
        <property type="entry name" value="Nonsense-mediated mRNA decay factor (Upf2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I074</accession>
    <name>A0A1B9I074_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_04617</name>
        <name evidence="4" type="ORF">I206_105797</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
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            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
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    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF48930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="WWC71838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="C:cytosol"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:D-arabinose 1-dehydrogenase [NAD(P)+] activity"/>
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        <property type="term" value="P:dehydro-D-arabinono-1,4-lactone biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
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        <property type="entry name" value="NADP_OxRdtase_dom"/>
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        <property type="entry name" value="GH17980P-RELATED"/>
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        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ALDKETRDTASE"/>
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        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OCF48930.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC71838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="418" mass="47703" checksum="D7B76CE1CA2F404F" modified="2016-11-02" version="1">MSSLPLPPYHPDQPEPSVPSFDIDSIPDEEIDHPSGNEELLPKVLKSPDDRNVIFPPLILGVSTFGYGIYADDDNIKSDLPLRIVRLAMRCGINAFDTSPWYHPSEIILGEVFKALNYPRESYHLITKVGKYGPNSKDHRFDPDTIRKSVERSLKRMNTDYLDVVYLHDIEYILPPPSYSGNPLDSINSILSLPLIPTKEEQILLTAIETLRELQNQGKILKVGIAGYPLQILLRISLLIYKITGKGLDLLQTYSHHTIQNDSLIEGYLNLFLNKSKIKQIISAAPLSMGLLTFKNCPNWHPSKSNLNLIKIIPKISKICFENNTTIEQISLRFGYRPLIENVNLPIVIGCIDLNQLHSTLKNWKEVNPSFTSEKQQKEFELQDKPKRQFEDKIKNMFEENGTRNWSWECPSQAQRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I0B5</accession>
    <name>A0A1B9I0B5_9TREE</name>
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        <recommendedName>
            <fullName evidence="12">E3 ubiquitin-protein ligase NRDP1</fullName>
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    <gene>
        <name evidence="9" type="ORF">I206_04673</name>
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    <organism evidence="9">
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
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        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="OCF48986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="WWC71894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010205.1">
        <property type="nucleotide sequence ID" value="XM_019156403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I0B5"/>
    <dbReference type="STRING" id="1296096.A0A1B9I0B5"/>
    <dbReference type="GeneID" id="30173042"/>
    <dbReference type="KEGG" id="kpin:30173042"/>
    <dbReference type="OrthoDB" id="1630758at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001293">
        <property type="entry name" value="Znf_TRAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF94">
        <property type="entry name" value="TNF RECEPTOR-ASSOCIATED FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15965">
        <property type="entry name" value="zf-TRAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50145">
        <property type="entry name" value="ZF_TRAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="19"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="TRAF-type" evidence="8">
        <location>
            <begin position="100"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="TRAF-type" evidence="8">
        <location>
            <begin position="183"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="4">
        <location>
            <begin position="100"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="4">
        <location>
            <begin position="183"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="299"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="459"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="556"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="332"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="460"/>
            <end position="486"/>
        </location>
    </feature>
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        <location>
            <begin position="507"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="521"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCF48986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC71894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="624" mass="68752" checksum="F4EE3F04168FFAC6" modified="2016-11-02" version="1">MSHEVIYNYVESIDPNLTCAICQSALVDPVTTTSCKHTFCRDCITRAIIVNPQCPIDRSALSISSLKETEQLVKLMLDELKVSCAAEGCGSIMERGLLLSHLRNCTKAIITCKDGNCGLSMARHRLPHHRAYECFQRRMECEKCGTVLVFKDRSAQKNPDCCQVSSTKCELCDEILGKDTPRHHWICPKKNVACPHGTRGCPAIIARSALQTHLDACPFEALSGFFEQNDARLRLLEQRNETLQAEIDLLKVEMQSSDVGRAESWNTRHTGNPFGFSIPSTTDSTSPWLDLDHPDINFSAQEVSSPSTPTTHVQALSENNNLNREPRLAIPANQSDQSNHTPTTPNSPSHASPQTQAAYPGVTTRAAADLARQRSMVIPTFGSHQSYADWTFNRLSSSNMPNIQDAIHALRDSVCQLAGGLDTMERRNEVRTMTESLRVLEEVGGLRAIVTTMRMQVMMSQPPTSSVASPSSHHTSSQVTQNNNNNFSPAISIPFSEPPSTQPTDRQDEDGEPVTEDSYLDPERSHSIRESHAFSRIVPEDARSSTSSLITAYNAASRNGSRRGRTIGSGAGLTGRTMAIPPPGENEATDTVLGGDRRNGRLSRANPMNLIRRQPSRFNHRPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I0I4</accession>
    <name>A0A1B9I0I4_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein CASP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">I206_04740</name>
        <name evidence="16" type="ORF">I206_105917</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CASP family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC71958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010272.1">
        <property type="nucleotide sequence ID" value="XM_019156470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I0I4"/>
    <dbReference type="STRING" id="1296096.A0A1B9I0I4"/>
    <dbReference type="GeneID" id="30173109"/>
    <dbReference type="KEGG" id="kpin:30173109"/>
    <dbReference type="OrthoDB" id="10257567at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012955">
        <property type="entry name" value="CASP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057476">
        <property type="entry name" value="Cux_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043">
        <property type="entry name" value="CCAAT DISPLACEMENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043:SF2">
        <property type="entry name" value="HOMEOBOX PROTEIN CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08172">
        <property type="entry name" value="CASP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25398">
        <property type="entry name" value="CUX1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15" id="KW-0371">Homeobox</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="650"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="Cux N-terminal" evidence="14">
        <location>
            <begin position="3"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="CASP C-terminal" evidence="13">
        <location>
            <begin position="436"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="558"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="121"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="242"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="410"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="502"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="561"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OCF49053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="WWC71958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="686" mass="78070" checksum="AFCC39B7BCE209C8" modified="2016-11-02" version="1">MAEENFSTALTTWKEINLSELQKSLDSTAVELVENQKENLVGRKKLAEQTREFKKLPDDAEKFNSIKVLLKAYQGEIDSLTRRSKMSETSFLNVYKLLADAPDPYPLLDAAVDQTVKIAEARVLESELNRLREENGELKKSLDEMKDVEDKKKKAENKVEQIEEKMEDLIQERVTQKENELNAEYDERMRNYEEREKDLQRQVETVRNQLRDMHSSNESTQAKLMNASQRQEQDVAARLAELDMVAADLSRANERVATVERRNELLRSEIESVRSGSQQAEKVKVLESQIEDLEAEASRLLRALDEIKERNAESQKAAKKKEDELVKEVASQNTEIHGLKTKVKQYSDYDEIKRELEIMKYVEFSGADFENDEEESSDYASPALTLPDPNASVANKSLNRSLENLLVSKNRRLLEDLTKLRVSFEDLSNEHSKTDEIISNLQNDLEKQLGLNEKLENDLININNKDGGNEDKETKGLQGLDIGGLKVDGRISPLGQSDNSILPIVTSQRDRFRQRNAELEEELRKQFEIISDLRIEIKSLQTDNLKLYEKVRYIGSYRDGSSSTSNPTNNSSNLSGYNVPGSSRGLNGVGVGIRRDEEIGKYKDKYDESLNPFEAFKGREAQRAIQALNPLERGVFALTRAIIGNKRARSLFILYAASLHLLILFVLWNTMAASDSTAHPPVPIHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I0J3</accession>
    <name>A0A1B9I0J3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_04722</name>
        <name evidence="4" type="ORF">I206_105900</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC71941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010254.1">
        <property type="nucleotide sequence ID" value="XM_019156452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I0J3"/>
    <dbReference type="STRING" id="1296096.A0A1B9I0J3"/>
    <dbReference type="GeneID" id="30173091"/>
    <dbReference type="KEGG" id="kpin:30173091"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF6">
        <property type="entry name" value="CYTOPLASMIC ALDEHYDE DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="2">
        <location>
            <begin position="46"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF49035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC71941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="513" mass="55447" checksum="7B29DCB9F6385284" modified="2016-11-02" version="1">MLVQSRLRGSVFCSSSRSFATTARRTNLPVVPLWINGQASTSSSGGSVTHKHPKSARETCEVIVAGEDETNQAILDSKRAFEDWRNVNGWERKGILQNVVQLLKDRKDTFTEALKADASFADIVIGGDQMSASHLVEGAANTAISVEGSIPQTKDDSFSMVLRQPYGPVLSIPAFNYPLTLALRSIAYPLACGNTVLLRASPLLPQFFGLLAPLFEDAGLPKGVLQTLNLSEKDAPARVEQLIAHRDVKMVNFTGSVRLGKILAAKCGEHLKPSVMELGGKSIAIVLPNADLKLAANNILFGAFFNSGQVCMSTEQVLVHSDIAAEFEEILKQTAEEAQWGEGMEMVRPDSGIGARAMYDDAVKGGAKPLYSASPSSTSSTTTSFPPTILTSLSPKTTLYREESFAPLLSLHTFDNIDKIIEYANSHSTGLSTSIFSQDFQESLELAKKLESGAVHVNGMTIHDQHNLPHGGWKNSGWGRFNGIGAIESFTQTKNIRFAKEAMLPIGAMYKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I0K2</accession>
    <name>A0A1B9I0K2_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell division control protein 24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">I206_04749</name>
        <name evidence="5" type="ORF">I206_105926</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC71967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010281.1">
        <property type="nucleotide sequence ID" value="XM_019156479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I0K2"/>
    <dbReference type="STRING" id="1296096.A0A1B9I0K2"/>
    <dbReference type="GeneID" id="30173118"/>
    <dbReference type="KEGG" id="kpin:30173118"/>
    <dbReference type="OrthoDB" id="1594986at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031106">
        <property type="term" value="P:septin ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05992">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13246">
        <property type="entry name" value="PH_Scd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000365">
        <property type="entry name" value="Related to CDC24-GTP/GDP exchange factor for Cdc42p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033511">
        <property type="entry name" value="Cdc24/Scd1_PH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053026">
        <property type="entry name" value="CDC42_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339:SF1">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15411">
        <property type="entry name" value="PH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="318"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="3">
        <location>
            <begin position="1033"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="678"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="804"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="973"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="292"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="687"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="765"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="824"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="911"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="927"/>
            <end position="936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF49062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC71967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1120" mass="123789" checksum="3674D0DCE2C30A89" modified="2016-11-02" version="1">MAVATMSMSGSISRKRVGSVSQNNNGSGVPPLDIQSIQMPSNKTNALALKTAALSSTKSLYQTCSILRKRLRCVEDFEAFLDQPASAEPLDVVSHMCHLFRLGSPLCHLYNLLIPSFTDPNSSLYAAYPTPPAIEYDFPPFVNSPDGVRNWAKRPENAKPCQRYIASFCMAMKKRHQEGRWQSEIWALHELWGKSNGDEIEAYDSTGLMKVLNTVEEILDHLPESAMSPLSPTTSHTASSSIHMKNNRQSYDLPFTMGGTGTGSGAIAKMAATMNGGVHLDSLTQVGNAMLNGSTSTGSSSPNGGEDMQRTKSTADANAFKSVEELVSSEKSYVQELEILVRCSMEMLDRHLVSTETNHQIFSNLAKILDFHRKFLIKLETEYEPIQEGRGPKAWAEGVWGRPFITSESEFDCYGPYCANYLDAITVVNEQMPILIRGQELPLDERPCLDPQRELQAFMIKPIQRITKYGLLLDAILHATAKHEYPFRPELEEASAAVKRIAASINEVTDFKAKQATVKELMDRVEDWKGHELDKFGDLWLDDHFTVTKADQPREYHVFLFEKMMLCCKEVLPERKKSSKNSSMLRKDKTISKSLEKRKLALKGRIFVSNINRATLLPPEPSPTDPYGVSRVCIAWTVPHRHPNGWHEDQEDSFIMIGRSEEQMKKWADKVMELATAERKKQEANRNSRPSMSNGRYSGSEKAYQHSSFAPPTPSAEKPPFAFAPPLPGQNSQFAGNEDDDEDGLISGRTTPSISNHGHGPGQMSPYTSVHPTTGRRVQSQQSMPAAMQAEFRARALTEDQFGPSMTQWRSQQQPMPPPLPRLTSAMSTLSTASEASFGNGLNSARSIGHPSMSRTISGAGSRILSRADETEEDSPTEQREAFNRYGPARGMTRAPSHGFPPSVPYPPQLRNRSASSPNVYQQPKMDPLPPIPAQVPHPFAAQPQQWSIDPQLSMSSSSTLLGGTAYFTKRMSAGGKRSSGESHSTETSETTSDQQSPATPYGSVPGDHPHTRGATPVSRQNSSDVVGVAGSSVLIKLRCGEDQFLIGVPQDINFPTLYQKIQKKIRLCSSSRNNIGDTLQIKWIDADQDEITIKCDADIEAMIGECMEVGASHVNLIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I0R5</accession>
    <name>A0A1B9I0R5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SUMO-conjugating enzyme UBC9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein 9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ubiquitin-conjugating enzyme E2-18 kDa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I206_04817</name>
        <name evidence="15" type="ORF">I206_105994</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010349.1">
        <property type="nucleotide sequence ID" value="XM_019156547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I0R5"/>
    <dbReference type="STRING" id="1296096.A0A1B9I0R5"/>
    <dbReference type="GeneID" id="30173186"/>
    <dbReference type="KEGG" id="kpin:30173186"/>
    <dbReference type="OrthoDB" id="6600758at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019789">
        <property type="term" value="F:SUMO transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23798">
        <property type="entry name" value="UBCc_UBE2I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000035">
        <property type="entry name" value="SUMO-conjugating enzyme ubc9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="13">
        <location>
            <begin position="4"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="11">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCF49130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WWC72035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="158" mass="18183" checksum="A062D61253E98ED5" modified="2016-11-02" version="1">MSNLAQARLHEERKQWRKDHPFGFFAKPVKAADGTLNIMLWEVGIPGKQGTIWDGGVYKVMMTFPDEFPTKPPKCKFDPPLFHPNVYPSGTICLSILDEEKNWKPSITIKQIVLGVQDLLDNPNIGDPAQIDAYQMYKNDKNAYERRVKQQAIERRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I1A5</accession>
    <name>A0A1B9I1A5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_05010</name>
        <name evidence="3" type="ORF">I206_106185</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010538.1">
        <property type="nucleotide sequence ID" value="XM_019156736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I1A5"/>
    <dbReference type="GeneID" id="30173379"/>
    <dbReference type="KEGG" id="kpin:30173379"/>
    <dbReference type="OrthoDB" id="2564945at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="392"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF49319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC72223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="459" mass="53241" checksum="F0D94F977885C182" modified="2016-11-02" version="1">MAFSSLADELAGEFENDQSMIIGLGQSLADEFIDVDKKEYKSGGVKDENEMNDDNQAELQNPITPIKIQQDLPNLQTPNNIKGQQSSKSSISYEFTNLDDISPNRGIDLNLELNLELSEKYEFSLNNNEFNDYQNYLNYSPTKNRSVKNRISNKSLKRLMSNRDDLNELPKDLIILSENLIGISKLLNDLKNLDHDSLNDNLQRHLNKMNDIEKIRDDWIRELNMCLNEFRLGNSEEYSNYDVLPKRNLEEDEEQEDEYGDSIGWIGKLNSEQDYQLSRQSHFSPEHITHLEVVNETTEEEEDNEHIDQYGTLMQDDFLIHQNALSPIISSISQELKPNLPILLNLLKLVQQDTENLIYSLSNLSENIHNCQSFGNSISRQIKGIKSSIDSLRERENLENEAKRKIEIYEQNKLKIGLTHSCDTNQNRLNKECKEFEGVLEIYERSLKSLLNNRETWVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I1M7</accession>
    <name>A0A1B9I1M7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Phosphatidylinositol transfer protein SFH5</fullName>
            <shortName evidence="15">PITP SFH5</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">I206_05098</name>
        <name evidence="18" type="ORF">I206_106272</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity. Regulates PtdIns(4,5)P2 homeostasis at the plasma membrane. Heme-binding protein that may play a role in organic oxidant-induced stress responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out)</text>
            <dbReference type="Rhea" id="RHEA:38691"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:38692"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 15">Endoplasmic reticulum membrane</location>
            <topology evidence="2 15">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Microsome membrane</location>
            <topology evidence="15">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the SFH5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894012">
        <property type="protein sequence ID" value="OCF49405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144526">
        <property type="protein sequence ID" value="WWC72310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010624.1">
        <property type="nucleotide sequence ID" value="XM_019156822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I1M7"/>
    <dbReference type="STRING" id="1296096.A0A1B9I1M7"/>
    <dbReference type="GeneID" id="30173467"/>
    <dbReference type="KEGG" id="kpin:30173467"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017157">
        <property type="term" value="P:regulation of exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042938">
        <property type="entry name" value="Sfh5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47669">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN SFH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47669:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN SFH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11 15" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0492">Microsome</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="16">
        <location>
            <begin position="138"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OCF49405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="WWC72310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="287" mass="32246" checksum="183FE998D8931165" modified="2016-11-02" version="1">MTTTSLPTWSELPADHPLLQLHSRLPTILEEANHSQIWGVRLIKTTPPAFSSLLILQKYLRSVANDVDNAAENLTKTLKWRKEFGLDKENAIPEEFGPDFEGLGYVTQVGKENGGANIVTWNVYGAVRDIKKPFGDLQRFLRWRIGLMERAISHLQLATTSTPIPDYGKGDDPHRIDQIHLYGGVSFLRMDPLIKAASKATIEIMQAHYPELLLRKFFVEVPLIMSWMFSAISFFVSAETAKKFQVISYKENLGKELGKLEDIPKDLGGNGPDLATLDKRLISDDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I1W3</accession>
    <name>A0A1B9I1W3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TPR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_03962</name>
        <name evidence="3" type="ORF">I206_104457</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010660.1">
        <property type="nucleotide sequence ID" value="XM_019155702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I1W3"/>
    <dbReference type="STRING" id="1296096.A0A1B9I1W3"/>
    <dbReference type="GeneID" id="30172331"/>
    <dbReference type="KEGG" id="kpin:30172331"/>
    <dbReference type="OrthoDB" id="414774at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45588">
        <property type="entry name" value="TPR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45588:SF1">
        <property type="entry name" value="WW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="34"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF49441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC70506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="567" mass="64914" checksum="E3427CD42973DFBD" modified="2016-11-02" version="1">MTVTLENIPSPSNGPYPYKLGTYSRSIQTASRECQVWFDRGLLWSYGFHHEEAARCFRRALDLDPGCAMAYWGIAYAAGPNYNRPWKMFNEEELKRLLTKCHSAGSKALEYATDSLEIALAQAILARYPLDEQGNPTAWNLAYSDRMAEVYQEFGDDLDVIALYADSLMAIAPWQLWDLQTGAPREDSRTSQIQSVLEKALRNPSSNTHPGILHMYIHLMELSPTPERAIPAADHLRGLCPDSGHLNHMPGHIDLLIGDYRRAISTNLQAIKGDEKNNYEGATTEFYYLYRLHNYAFVIYAAMLNGQFSIAQETLDKLETHLTDDLYRRIDPPLINFIEGSKSYRVHLLVRFGKWQDILNLPFPDDREFYCVTTTILHYARGVAFSVLGDLDNASKEQSLFRQSRKKVPSTRYNFRNSWQDILNIAETMLGGELEYRRGNYEHAFEQLRQSIYYCDNMIYSEPWAWMQPPRHAYAALQLEQGNLEEAAKVYAEDLGFSDTLPRAVRHLNNVWALHGYHECLKRLGRTQEARMIEPQLGLALAVADVPIESSCFCRRISSPPDEAGYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I2A5</accession>
    <name>A0A1B9I2A5_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="18">DNA repair protein RAD5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">I206_04176</name>
        <name evidence="19" type="ORF">I206_104246</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019010873.1">
        <property type="nucleotide sequence ID" value="XM_019155915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I2A5"/>
    <dbReference type="STRING" id="1296096.A0A1B9I2A5"/>
    <dbReference type="GeneID" id="30172545"/>
    <dbReference type="KEGG" id="kpin:30172545"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014905">
        <property type="entry name" value="HIRAN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF22">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08797">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00910">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="512"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="919"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="1012"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="348"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="362"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OCF49654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="WWC70296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1193" mass="133157" checksum="F815E184F9982F2D" modified="2016-11-02" version="1">MDIEDDSPPINSKRSSPDLFFPVSDSEEEDVITASGALAGPSSSSVVAPPSTSTSSRAHGNAVQSQSQRTNGGTGEIEFFGSQNSDDIIPLDTMSNALAGPSKVKRPLSQSPPAVIPLEFEQGYLGEFVCEGWSLSKGKGYCSPGSKVIFERPKIKVDEPFPKGKEKLGGPARLVNGRVVGTQKKPIGGKQVTLGSMMSKKAPPPPKKTVGKPVIDSIIRFRNDRGFEVGRLSVQEAGFLTHLLDTGVIALSGHVIDCPQSLSTGSTILLNVRVYLARKAFEKVEKDGRREEGSFWQEQKETTEEEAMRKRKDALGALFSRIGVKPIHSNALLLAQKKNGAAEINETSLKHFTDSPKPKRSPSPSKGSNGSGVEKGKGKTSATNSDNEDEDEDSGDEAEKLDDQQMNEIDTIYRKAQQGDNRLEETNPPDTFLYTLRPYQKQALTWMSAREKGDESIRDNNNSLHPLWEEYAFRKEQTAGQPIEIEDDDDFVDPSRKFYWNPYSGELSLTFPTSNTRAKGGILADAMGMGKTCMMASLIHANMDSDISSTPPPTAEAEDELASKRPKFKQVTLSNQWRAIPTIPKAVNLPRGTLVVCPVSLASQWHDELGKMSEKGTITSFMWYGNDRADIERLLAQEGKKKVDVIITSYGTLASEYQKWNKNKDKPTYEGGSLYDHDFLRIVLDEAHNIKNRTALVSKACYELKGQRRWALTGTPIVNRLDDLYSLLHFLRLEPWGHYSFFRSFVTIPFLNQDPKALNVVQYILESCLLRREKTMRDKDGKLIVDLPPKHVEIQVLDFSRPERQIYKHLEDRAKRRFIQLDAEGRAMSNYTSILAMLMKLRQCVDHPLLVLGKLNEDDEIAEKLLDAETGDEKNNLKDLIALYAGGAKSTENEKEEVDHAFAAKVLKELGEQESTPICDICSNEMFDEVLLPCYHRCCQDCIVDWIGICEDQNKPALCPSCSKGPIKLSDLRSIQRKKKRVNPLNGLSLTENDQDKKDVVIGKVDLVQSTKLRALVRKLEQMRMEDPTVKTLVFSQFTSFLDLIETTLTREGVKWLRFDGSMSQAQRATTIEEFGKKIKEPLVLLISLKAGGVGLNLTMANHVFMMDTWWNEAIEQQAIDRVHRLGQNKPVYVTRYIIKGTVEKRIMKIQRSKTALVNASLSGGGSKDKGASLADIKKIFGLDEDDSEDEVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I2U2</accession>
    <name>A0A1B9I2U2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">DNA topoisomerase 2</fullName>
            <ecNumber evidence="5 16">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">I206_04361</name>
        <name evidence="21" type="ORF">I206_104063</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="21" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14 16">Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15 16">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="16">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the type II topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="5 16"/>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144523">
        <property type="protein sequence ID" value="WWC70116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011053.1">
        <property type="nucleotide sequence ID" value="XM_019156095.1"/>
    </dbReference>
    <dbReference type="STRING" id="1296096.A0A1B9I2U2"/>
    <dbReference type="GeneID" id="30172730"/>
    <dbReference type="KEGG" id="kpin:30172730"/>
    <dbReference type="OrthoDB" id="276498at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16930">
        <property type="entry name" value="HATPase_TopII-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03481">
        <property type="entry name" value="TopoIIA_Trans_ScTopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03365">
        <property type="entry name" value="TOPRIM_TopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.40:FF:000003">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.30:FF:000001">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000008">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000004">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.670:FF:000001">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.199.10:FF:000002">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="entry name" value="Topoisomerase II, domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="entry name" value="Topoisomerase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Topo_IIA"/>
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        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
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        <property type="entry name" value="Topo_IIA_B_C"/>
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    <dbReference type="PANTHER" id="PTHR10169:SF38">
        <property type="entry name" value="DNA TOPOISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169">
        <property type="entry name" value="DNA TOPOISOMERASE/GYRASE"/>
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            <begin position="543"/>
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    <sequence length="1484" mass="165447" checksum="AD11209E2EDE4D6D" modified="2016-11-02" version="1">MSDSESDGFVVADSGSESEGYIQSSKAKKPVAEKKAPAKKAAVSKAPKASTVKKSATKKTPLASKNLPNDSISEVESDFVDSPAKPKAKVVDDDDNFGAGPSTAAPAKNKSASEVYQKLSQRDHVLKRPDTYIGSVEAISQKMWVFEEETKGMIYRDITFVPGFLKIFDEILVNAADNKINDATMDSIKVTIDREKNTISVYNNGKGIPVEMHKKEGVMIPELIFGHLLAGSNFDDDQKKLTGGRNGYGAKLANIYSHEFIVETADKVNGKKYKQVFSNNMDKKGAPKITENKKGEEWTKITFTPDLPRFGMTGIDDDTNALLMKRVYDMAGTVKDIKVFLNDERLKIKGFKQYVEMYVNSASAATSAEGMAMSKPPLVYEVVNKRWEIAFTLSDGEMKQVSFANSIATTKGGTHVDMVSTQLANKLLEQIKKKNKAAPVKPFQVKNHMWIFVNALIENPAFDSQTKENLTLKSSAFGSKCDLSEDFIKKVTKTGIIDNVLSWARFKQDQIMKKSDGAKRSRVGGIVNLEDANQAGGRNSKNCTLILTEGLSAKALAVSGLSVIGRDNYGVFPLRGKLLNVREAGHEQIIKNAELNHLRQILGLKHKQDYTTTDSLRYGHLMIMTDQDHDGSHIKGLLINFFDHAYPSLLRIPNFLLEFITPIVKVWKGKQEHTFYTMPQYEEWKAENNEGRGWESKYYKGLGTSKAEDAQKYFADLDRHRLAFDTLKTEDRGLIDMAFSKKKADDRKEWLRQFKPGTFLDHDTDVIPISDFVNKELILFSMADNLRSIPSVADGLKPGQRKVMFATFKRNLTKEIKVAQLVGYVSEKTAYHHGEASLASTIVGLAQTFVGSNNINLLAPNGQFGTRLSGGKDAASPRYIYTAIPRMTRAIFNPADEGLLNYLIEEGMGIEPDYYMPTVPLVLINGADGIGTGWSTSIPNYNPVDIVENIRRMMRGEEPQRMNPWFRGFKGSIERIEQDKYKISGIIEKIDDKTIEITELPIRKWTQDFKEMIEEMTTGTDKVPSSIKDYEEHHTESTVHFKLHLSEAAMKAAEEEGLEKRFKMSTTLSTGNMVCFDLNGKIRKYANAEDILSDFFGKRLEFYGLRKQWLADELNKQFEKLSNQARFVTMIIAKELNVNNKKKSVIVDELRALNFRPFPKKVAAKEAGETENVLEEEDEGMASDYDYLLGMAIWSLTVEKVNKLLAERDTKEAELIELLKLSPQDIWNTDLDKFLEEWQLCLDNDTLAAKGLKPKTKGAIKAAAKKKKRAAGEDTDDEEEDFKPKAAAKPRAKPKPKASPVKKSPVKRDSTNVSDEEDIKPPTKKLAATKTTSKPKAKIETKMDFDESDDDMYTVSAAKATLSTGVTKSKPAVASIIEDDSDNTPIKSKPKAKPAPKKKAAPMSDESDIDIIPSKPAPKTKAKAPTKANKVKEESESDFDDSMDIDTFEPSPVAPRKTAPRAGRGATKKAAYVDLSDLDDDADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I3B7</accession>
    <name>A0A1B9I3B7_9TREE</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_04499</name>
        <name evidence="4" type="ORF">I206_103928</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894011">
        <property type="protein sequence ID" value="OCF49968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC69984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_019156229.1"/>
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        <property type="component" value="Chromosome 5"/>
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        <property type="entry name" value="Promethin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
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        <location>
            <begin position="282"/>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
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        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
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        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
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        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
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            <begin position="356"/>
            <end position="376"/>
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            <begin position="394"/>
            <end position="403"/>
        </location>
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            <dbReference type="EMBL" id="WWC69984.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="403" mass="43481" checksum="4F59D5EA76045F69" modified="2016-11-02" version="1">MSSLADDEFGDIVKISPPTTSTPLFPSHNDENGFNSQLNAAMDSNESNSAAAVSEIPKEVDTKYDIKPIIKPSSGEGPISILKTSSSPSTPIKKEIKLVIKQDKLPEQAHQDMNGVFDDTVKKVKIQSDKLQTAAQPYADKTRNFAESRPVLFTFIALWAAFSAIPIFIFLGFALITTLVIMSTAIFFSALIIIGAVLMGGGALIGTLLFGVALLVPIIFITTFLAVGSLTTLLGLFLVHRLYLNIANAAVQEGWTANAIISGIKAWIEETSIRIRSSSPFRKSSSIIGNDKKSKHGHKHHHKLGSSGPNNASTVISTAPREKLQGFGTLEENKTDDQFNIRDEKVKPHEYEGDQQDIQSQASTSTASSRTSHGTALSEKIGHGNIEGIPKLGDLSEKSSHEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I3M2</accession>
    <name>A0A1B9I3M2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Solute carrier family 39 (Zinc transporter), member 1/2/3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">I206_03367</name>
        <name evidence="9" type="ORF">I206_105730</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011270.1">
        <property type="nucleotide sequence ID" value="XM_019155116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I3M2"/>
    <dbReference type="STRING" id="1296096.A0A1B9I3M2"/>
    <dbReference type="GeneID" id="30171736"/>
    <dbReference type="KEGG" id="kpin:30171736"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF44">
        <property type="entry name" value="PROTEIN ZNTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628303" description="Solute carrier family 39 (Zinc transporter), member 1/2/3" evidence="7">
        <location>
            <begin position="18"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="468"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="36"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="296"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OCF50051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="WWC71771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="489" mass="51824" checksum="6DEA7D6444AAAD48" modified="2016-11-02" version="1">MSLTILFALLAVAAVNAQFGPASSLSASGSRSTSARAATTSQSGAPINSSASSISTSPTSSGVPAPPTESVGCVLHVDHYHCTGTAPGYEASPTTGDPNTPNPTESSYCSWHETHWDCFDSAEELEATGSAEDTGECIIHVGHTHGDCSAEDLACGAVLLENFNMPLHIGALFIILVTSGLGAMIPLVTGWARRRSSSTESLDTLSTLGDFDQQTAFGRKAGIWSNIFYIAKHFGTGIIISTAFIHLLFHGFVMFQNECVGHLAYESTAPAISMAAAFVTFLFDFIGSRAAHKKYEHTQSVESPRAEKEAERTHDHSHDGHDHGYDLVLEGKQNWGVVLLEMGIIFHSVMIGVTLGAGSGNGWATLLIVIVFHQFFEGLALGARIALLRTISKPKQFLMALTFTLITPVGIAIGIGVRKSFSQNGKASLLSVGILNSVSAGILLYAAFRLLSCDFTDGPLRDAKPFKVIVAILAMVAGMICMSVLGKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I3M8</accession>
    <name>A0A1B9I3M8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase III subunit RPC3</fullName>
            <shortName evidence="6">RNA polymerase III subunit C3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_03377</name>
        <name evidence="11" type="ORF">I206_105720</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011280.1">
        <property type="nucleotide sequence ID" value="XM_019155126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I3M8"/>
    <dbReference type="STRING" id="1296096.A0A1B9I3M8"/>
    <dbReference type="GeneID" id="30171746"/>
    <dbReference type="KEGG" id="kpin:30171746"/>
    <dbReference type="OrthoDB" id="272392at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055207">
        <property type="entry name" value="POLR3C_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013197">
        <property type="entry name" value="RNA_pol_III_RPC82-rel_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008806">
        <property type="entry name" value="RNA_pol_III_Rpc82_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039748">
        <property type="entry name" value="RPC3"/>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
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    <dbReference type="PANTHER" id="PTHR12949:SF0">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12949">
        <property type="entry name" value="RNA POLYMERASE III DNA DIRECTED -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_9"/>
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    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpc82"/>
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    <keyword evidence="2 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
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        </location>
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            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023163"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00025127"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU367076"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF05645"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08221"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF22536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OCF50061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="WWC71761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="571" mass="64753" checksum="2D4662A720672557" modified="2016-11-02" version="1">MRNNGKEAVRLCEHIVRQAFGEVICRVASTLLNRGRLPLSTISRLSALPKPTTSAALIILIQHDLVQTNGASFKNTGDDEQYEFDTYTCLLRLRWGRILAITLQTYDEVALEVVRTIMIYGKMKVPDIIDACGGTNDAIRAEVVNNAIIALIRAQFIRPTSPEMHILDSDQIQRRFNLHRIELIKNKGTAMLSAVDIENCEAKAKHEIREEKEDLQDIRRILIERPKLDKDLNNKKKKRSKVNMILGNVEEEFDYELQQNIHLRINYDRFGILIRNELLVQAAEERWNKAAGIVMKAILQASLKDYSRLSEERSGDFIGTNSIVTLIDEKDYPVLLAGLAISSRSTIPEVIRNYLNILSGEDGSAGSAPFLRKDNGTNPGYIVEIEIICRKLRENVLYQLVREKLGDKAARVLAVVSKSSKAFETTVRDCAMLPLKDARMHLANLQRLSLVETQEVPKTAAKSRMGLPSSAEYHLWAMDETRVYETLLTNVYKSLGNILQRKSKEIEEKRIVLARENKAEELGSNKLMLSNKDQEDLLELDDYLKKLSLAEMRSELIVFVLRDLPGSPGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I3Y1</accession>
    <name>A0A1B9I3Y1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PSP1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_03545</name>
        <name evidence="4" type="ORF">I206_105552</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011445.1">
        <property type="nucleotide sequence ID" value="XM_019155291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I3Y1"/>
    <dbReference type="GeneID" id="30171914"/>
    <dbReference type="KEGG" id="kpin:30171914"/>
    <dbReference type="OrthoDB" id="243127at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047767">
        <property type="entry name" value="PSP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041131">
        <property type="entry name" value="RicT_YaaT_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830:SF3">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="2">
        <location>
            <begin position="821"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="603"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="750"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="315"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="751"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF50226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC71594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="915" mass="96678" checksum="C1D42F6D3C6A19F9" modified="2016-11-02" version="1">MSTSSLSGSQTLPPINNPNSPNPNAPIFRPSPARATSLTGTPFQYKTRAASQPAGERIPPSSSTPGSGRGSPGVNGNGAGSAYGVIGGARTPGRFSAALAGTNGTQTRANSFSAGEVREPRNMILNRTLSSHTEEFVPSRSQSTSPFPTFSPNSTPSTSPAAIRQNPLPPSPPKAGTHISRSRSQSLATGVRPSHIERPWLGTMSTLENVGAFSKIDVGWNISPNEGSNMSPFSRGLPSLGNNPAREEVYGRNGVHSSASRFKTIQEGYNTSGWGAGSSEQNNSATALSNSVHKALGGGEHYNQASSGEGYGNHHSNTNGNRSGTSSRRHSVSVVGGPGGRREFAFGEPGMGISSISPPTTSNSRGLFGFEDDMGNALNLNIERPRRGDMQDKVPFESTSLPQFGIDDRFPHEGHQRIPSLSRPKNGEIFSSFGSTPPRGRLDVLGSTATVEERDRAISSDSTANSKRFPMDSAAVGSPVIAHEISLNGNGNALSGSPEGTKEALPKMSSGPGIIGSSLTGTNFGSGQGLPPPPPFMPGQSYTGNSRPFGNPPVTSNGAFGPPSGLGLMSSGSSGLMGSPGVFGKPPMGPGYGGGGGYYGRPPIGSGNFSPQLGYNGHSLPPQGGFTSPPSGPYPPQGLPQGSYGYYGGPPSPQPPQQTSPSFSQLSLADLGKGISLNDLPSSTPLYIVTFKANRRDVFYCPDPTLLITTGDRVIVEADRGSDLGTVVYDLTPMDIREWQERQATAALLSGASQHQPPGLTLSNSANPPPAKEQKKRISGEFEYSKADLDGLLATCGPSGQPDLSGTTIVRGPLAKEIQPKRIFAKAAQTAEEQNRMREKANDEHEALMICREKVVQRGLPMHIVDAEYQWDRRKLTFYFKADKRVDFRDLTKENFRIFKSRIWMSMVPKDDPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I3Y7</accession>
    <name>A0A1B9I3Y7_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_03549</name>
        <name evidence="3" type="ORF">I206_105548</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I4G1</accession>
    <name>A0A1B9I4G1_9TREE</name>
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        <submittedName>
            <fullName evidence="5">Alginate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_03715</name>
        <name evidence="6" type="ORF">I206_105377</name>
    </gene>
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        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
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    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894010">
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        <property type="protein sequence ID" value="WWC71421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_019155459.1"/>
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    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR048958">
        <property type="entry name" value="Polysacc_lyase_14"/>
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    <dbReference type="PANTHER" id="PTHR40124">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40124:SF1">
        <property type="entry name" value="DISAGGREGATASE RELATED REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21294">
        <property type="entry name" value="Polysacc_lyase_14"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008628327" evidence="3">
        <location>
            <begin position="24"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Polysaccharide lyase 14" evidence="4">
        <location>
            <begin position="135"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="82"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF50394.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC71421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="405" mass="42954" checksum="A38A6DADD8E98D7A" modified="2016-11-02" version="1">MLHAIPTSSAIILVSTLLTYTSAVSTQDVASQYGLTASYNFTFPDETLNSADANTWIDGQWSLYNKKGVDWGNSDIVFSPDPSTSTSTLVRRQESSTSSSKSSTKTKTSSAASSSSTASTTTSVAYPASTNLDGEAPVLRIEYPQGSYSKKTGGTQFYADPLMSTDAKVASSSSGSNTTTTGQYERMMLSYDVWFPSGYAWNQGGKLPGLRGGPDPKGCSGGNQTDGTTCFSTRLMWRPNGAGEVYAYIPTSQKNFCSQSQVTCNSDYGTSLARGSFSFVTGQWQTIQLLVILNEVGTANGIVELWYNGVQALSFQNLVIRTSTNLNSVGGLFFSSFFGGDDSSWATPTDQFVYFKNIQLYAGAGASNVTGDKATVSSATPVQVILGGWTILGSVVLALFGLSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I4M0</accession>
    <name>A0A1B9I4M0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Spermidine synthase</fullName>
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    <gene>
        <name evidence="9" type="ORF">I206_03802</name>
        <name evidence="10" type="ORF">I206_105289</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
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                <person name="Goldberg J."/>
                <person name="Griggs A."/>
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                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Murphy C."/>
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                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
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                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">CBS 10737</strain>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
    </reference>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="1 7">Belongs to the spermidine/spermine synthase family.</text>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I4V3</accession>
    <name>A0A1B9I4V3_9TREE</name>
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        <name evidence="2" type="ORF">I206_105214</name>
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        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
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    <reference evidence="1" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
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                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
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                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="WWC71261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="kpin:30172246"/>
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        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OCF50552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="WWC71261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="284" mass="32214" checksum="A79F12354D6FD699" modified="2016-11-02" version="1">MPCSLPSVKFPSVRHEAEDASLKLHYEGTLSDQSGDDTKYPVQIVTIHSLLTKRLDPNSEYCPTAEECEALDKVCVENRTNETTRSIGVNIVKTGNIDPTKPSGRHKFQVFAGDLVEDYRNSLFFVPISEDGKGMRKTWLMNRENHGRSMWSTVTAKEEVSTLMENTITHAYRVDEEGGITREIPTITPIPWPIEGSVVDRVDLHTDIMENDRSDSWWRSHESDRVKDTACTLNVTALIPHDESEQKNTKAPILFLHGQVDVSQDKTDQWWDGPITWYTPEQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I510</accession>
    <name>A0A1B9I510_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_03931</name>
        <name evidence="3" type="ORF">I206_105159</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894010">
        <property type="protein sequence ID" value="OCF50606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144525">
        <property type="protein sequence ID" value="WWC71206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011825.1">
        <property type="nucleotide sequence ID" value="XM_019155671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I510"/>
    <dbReference type="STRING" id="1296096.A0A1B9I510"/>
    <dbReference type="GeneID" id="30172300"/>
    <dbReference type="KEGG" id="kpin:30172300"/>
    <dbReference type="OrthoDB" id="28755at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490:SF1">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF50606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC71206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="316" mass="36395" checksum="5040DB4FDB049360" modified="2016-11-02" version="1">MGLWESIPPEYQDNLTRIWTSPKKRAAAMAVLLMVAIIGLYASFGPVATSLPSISKENAIRRDDWQTTSDYDIVLSHYNEDLNIMRESIESVRSRLPSTHSKRVIIYSKGSVDQDGLQELLDMSDEVVQIPNVGREGETYLSHIVRHYDTASTNIAGHTIFMQPHVAWWWVFLPRLEKVLDKNTGFLSFGPYITHICGNDTHGQFHPRMADIYSMFQMDFCPPEPVLGTWAGQFTVSRHRILENPFKVYANLRQKFHEPKDHWIFKEGWWNNEPSNPTLGHALERSWPMIFNCTDPLIEKQCDENVQNSHCQCTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I566</accession>
    <name>A0A1B9I566_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM complex subunit LSM4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LSM4</name>
        <name evidence="12" type="ORF">I206_02725</name>
        <name evidence="13" type="ORF">I206_102378</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF50670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019011889.1">
        <property type="nucleotide sequence ID" value="XM_019154486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I566"/>
    <dbReference type="STRING" id="1296096.A0A1B9I566"/>
    <dbReference type="GeneID" id="30171094"/>
    <dbReference type="KEGG" id="kpin:30171094"/>
    <dbReference type="OrthoDB" id="747253at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097525">
        <property type="term" value="C:spliceosomal snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01723">
        <property type="entry name" value="LSm4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000024">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034101">
        <property type="entry name" value="Lsm4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="2"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="81"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="108"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCF50670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC68450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="152" mass="16009" checksum="862FE550F984738E" modified="2016-11-02" version="1">MLPLSLLNAAQGKPMLVELKNGVTFNGHLVECDNFMNVTLREVYQTSADGERFWKMKEMFIKGNIIKYFRIADSILDTAMEEQDKQRAANRQRGGNRGGRGNQSNNRGGRGGQPGRGGPPGRGGGPGGGGRGGPGGRGGRGGPRGGRGGGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I5L1</accession>
    <name>A0A1B9I5L1_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phenylalanine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phenylalanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">I206_02867</name>
        <name evidence="18" type="ORF">I206_102516</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="3"/>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF50810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012029.1">
        <property type="nucleotide sequence ID" value="XM_019154626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I5L1"/>
    <dbReference type="STRING" id="1296096.A0A1B9I5L1"/>
    <dbReference type="GeneID" id="30171236"/>
    <dbReference type="KEGG" id="kpin:30171236"/>
    <dbReference type="OrthoDB" id="4457at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.380:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000053">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="entry name" value="Ferrodoxin-fold anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00469">
        <property type="entry name" value="pheS_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="Anticodon-binding domain of PheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="15">
        <location>
            <begin position="161"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="16">
        <location>
            <begin position="359"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OCF50810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="WWC68586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="475" mass="55087" checksum="70C7624D69EFF014" modified="2016-11-02" version="1">MSVRLATRLVASSSRLPSCSKSSFTIPIKPVRYSFRSQSTISTPESYKYNGITYPKDSYSNVPSSILDKLDRNLHLMPSHPISILRQIVENHFNDYKALIPSSAIVSVKQNFDELGFPLNHPGRSLTDSYYLNKEYMLRTHTSSHEIESYKKGLNKWLLSADVFRRDEIDSSHYPVFHQMEGTHIWLNSELNQLNELNKNLENQLKNIPIIIEDETKISNSNPFQSHHNPIYTEQIIKHLKNSLNSLIFKLFGHHTKSDGEPLRVRWIEAYFPFTTPSYEVEVFWQGEWLELLGCGVVMQKTLDQSGVSDKSGWAFGLGLERLSMVLFSIPDIRLFWTSDSRFLSQFKQGEITTFQPYSKFPPCYKDMSFWLPQTDENRHESTSSSAGGKTLNPMTSQKQFHENDYCEIVRDVVGDLIESVTLIDEFTHPKTNRKSKCYRLNYRHMDRNLSNEEVNELQNKVQARVVEEMGIEMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I5Q3</accession>
    <name>A0A1B9I5Q3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Gamma-tubulin complex component 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_02900</name>
        <name evidence="10" type="ORF">I206_102550</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF50843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC68620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012062.1">
        <property type="nucleotide sequence ID" value="XM_019154659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I5Q3"/>
    <dbReference type="STRING" id="1296096.A0A1B9I5Q3"/>
    <dbReference type="GeneID" id="30171269"/>
    <dbReference type="KEGG" id="kpin:30171269"/>
    <dbReference type="OrthoDB" id="5860513at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:spindle pole"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF14">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="256"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="625"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="178"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="202"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OCF50843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC68620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="984" mass="110544" checksum="1BC12BE960C18402" modified="2016-11-02" version="1">MSSRPSSSLSTHRNRPSTSTARPPLEQLVYSLVPSLAPPRSSRLNHDVRSGRSSVASSRPESRAEIDGEAEKERKERVKELMEWCEEIMESELPSSAPLSTPTLPDTAKRMLLQSSRTDSRSASRQSNRGETSSSGSERAMKFSGIWNKLERGRLLSSPLPHLQFLLALSEYNPDNASLKSANTNSNPIHSSSRAMPPPATFPSNQPSSSRQPLTATGSINLPALEIDVKGKSKADVLKAWRSSKSEKPFPPHLLLRDTLYLMQGIDGRYVRFALRSPREQNPYLTEKGRAGDGTGFPLGKDGAVGQVDEGEEGDIVGIEIIADQAKDGYISKPTQTILTQLSEMGMLYRQVTDFINSRQAGESKGGMTEQSLCHFLHHELSEYHRLLAVLESQMNQTTEQNEQPAEGAGLTLMRLGLWTEEMRLKLKQMSLVVDEAKKVHGGALVSKIHKHTSHGDPLIRKFTDQILEEVSKPFFATLQRWIFAGDLNDPFKEFFVQLNPETVSVRDGRISPAGDVGFEVGIDHAGGTDEAHKVWEKKYVFVKGMVPGFVSEEFGKKIFSTGRSLNFIRYSCGDSDWIETQAKLANAGRALKYSDLAGLERSIDDAYSIASQRLLEIFFDKFVLLDHLRALKSYLMLGAGDFTELLMEALAPRLSKPAISLYRHHLTSDLESAIRGSNAQFDDPDILRRLDARILEYSHGETGWDCFALEYKVEAPLNAVLDHKAMLDYDRLFNHLWRLKRVESALTQGWIRVTSTSKAYEGIPGLSNDWHHCRIVQAEMVHFLRNLQAFYQLEVIECSWQALMEFTEKREGDLDALISAHREYLDRVVRKVLLLSSKRDKEEVLLETVREALDFILQFRDATDDLYGWSLAEATRLDRERDAERGLYTIPTNDSPTISSQQLQSIRQRVKNCSNSFQDRLISICHLAGSHTDLDVRFLAIRIAWNGHYSLRKSKSNNLTLIPSTTGTSVIGSERASSTRSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I678</accession>
    <name>A0A1B9I678_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Endoribonuclease YSH1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_03072</name>
        <name evidence="13" type="ORF">I206_102718</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF51008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012227.1">
        <property type="nucleotide sequence ID" value="XM_019154824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I678"/>
    <dbReference type="STRING" id="1296096.A0A1B9I678"/>
    <dbReference type="GeneID" id="30171441"/>
    <dbReference type="KEGG" id="kpin:30171441"/>
    <dbReference type="OrthoDB" id="10249535at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021718">
        <property type="entry name" value="CPSF73-100_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF11">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11718">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01098">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="9">
        <location>
            <begin position="43"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="10">
        <location>
            <begin position="271"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term" evidence="11">
        <location>
            <begin position="503"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="622"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="635"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OCF51008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="WWC68783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="756" mass="84375" checksum="F27EE776CFE04708" modified="2016-11-02" version="1">MHRHPRRHYKSQNAIQPPIQVLSPAGDDEPLTITMLGAGQEVGRSCCVIEHRGKKIVCDAGLHPAHPGLGSLPFIDEVDWSTVDAILVTHFHVDHAAALPYIMEKTNFKDGNGKVYMTHATKAIYGLTMMDTVRINDQNPDVSGKLYDEADVQSSWQSTIAVDYHQDIVISGGLRFTPYHAGHVLGASMFMIEIAGLKILYTGDYSREEDRHLVVAEIPPIKPDVMICESTFGVHTLPDRKEKEEQFTTLVANIVRRGGRCLMPIPSFGNGQELALLLDEFWSEHPELQNIPVYFASGLFQRGMRVYKTYVHTMNQNIRSRFARRDNPFDFKFVKWLKDPKKLNEHKGPCVVMASAQFMSFGLSRELLEDWAADSKNGVIVTGYSIEGTMARTLLSEPDHIESLKGGNIPRRLTVKEISFGAHVDYAQNSKFIQEIGAQHIVLVHGEASQMGRLRAALRDTYATRGQEINIHTPRNCEPLVLTFRQERVVKAIGSLAADRPVHGTPLKGLLVSKDFSYTLLDPKDLKDFTGLSTSTLLQKQSIPIGVDWSVIRWHLEGMYGEVEEGFDEEGKASFTIMNAVKVVQISEMVVEIQWSSNSSNDMIADSALAVLLGIDGSPATVKLTSHPHQHSHHDHSNSHKDDTTNRNSDENELIKGNEEFDKIKMFLEAHFGNVSGPNLSLAEGEEDELLLMTINIDEVIAKLDLISMRVESDSSDLKKRVETVLEMALTTLQPLSRRFIGSGVNLNLNEITITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I679</accession>
    <name>A0A1B9I679_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Translation initiation factor IF-2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">I206_03104</name>
        <name evidence="15" type="ORF">I206_102749</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI894009">
        <property type="protein sequence ID" value="OCF51039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144521">
        <property type="protein sequence ID" value="WWC68814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019012258.1">
        <property type="nucleotide sequence ID" value="XM_019154855.1"/>
    </dbReference>
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    <dbReference type="STRING" id="1296096.A0A1B9I679"/>
    <dbReference type="GeneID" id="30171473"/>
    <dbReference type="KEGG" id="kpin:30171473"/>
    <dbReference type="OrthoDB" id="361630at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03692">
        <property type="entry name" value="mtIF2_IVc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000007">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000008">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000001">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000019">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00487">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF20">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01176">
        <property type="entry name" value="IF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 14" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="13">
        <location>
            <begin position="385"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="45"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="675"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OCF51039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="WWC68814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="941" mass="103271" checksum="452975988C7F7195" modified="2016-11-02" version="1">MATTITHCRCCRGILYHLPSSSSSSKRQFASTAYNFAEKNEGFKLPSRDWSVKPSPSSRSNDGAFKRGPREDGRPKRKGNRPNEGRDSNSGGGPSNFRKPFGGRNDRAGESSNKWGVSRESARDSGITLGSGFGLKSAKVKAEGSEENDSNSGLRDLIEKSRKTNRIQRLPQQKNRGSAAFGDLLGSTSDGQPFKENPIDISPIGEKGEVSIEGGSTIVEEGDTSEYGKRQHGQRDRRSSHNRREGGSLLSRLSEAEELALPSRPHHNHKRNPHPLQPSSTQDQIQRKPKFIKPKVVQQEKQVYIPRTISVANLAKIFGVKLFHLQTRMSRLDMSEDQRRSDYLLNAEQACDIAIEYGFDPIVDDEASFDIYPDPDTADGKEHPLRPPVVTIMGHVDHGKTTLLDSLRHTTVAAGEAGGITQHIGAFSVPLSSLLPAGSVTNSSSPSTITFLDTPGHAAFTAMRARGASVTDIVVLVVAADDGVMPQTKEVLELVKSEGDKVGLVVAINKCDKPGVDFNKVKSALGAEGIHLEEDGGDIPSVKVSGLAKLGLDDLVETLSTLAEIRDLRARKEGKAEGYVLESRVDKGRGNVATVLITRGTLKTGSSIVAGQTWCRVRQMQDDKGKPIKEALPGQPISITGWKELPLAGDELLEAVKGEDEAKKAINNRKRDEERKRMMIDVEQINAKRKEERERLEAEAALNEAIESGNKINNSEEGIKKEEEKKILRLVIKADVSGTVEAVVGSLENIGNKEAGVKIVHTGVGEISESDVTLAEASDATIIGFNVKASRSIQTLTKSKQIPIEIESVIYRLIEKVKTKVINLLPPKIEYSVKGEAIIQQLFQINIKKKEFITIAGCRINNGIINKSDNENLIIKVFRGNKREDENLIYKGKIENLKHLKKDVLEVRKGMECGISLKDFNDLKQGDEIIMYNKIQVQREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1B9I6W1_9TREE</name>
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        <name evidence="3" type="ORF">I206_104469</name>
    </gene>
    <organism evidence="2">
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        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC70518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I6W1"/>
    <dbReference type="GeneID" id="30170368"/>
    <dbReference type="KEGG" id="kpin:30170368"/>
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        <property type="component" value="Chromosome 6"/>
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        <location>
            <begin position="300"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
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        </location>
    </feature>
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        <location>
            <begin position="323"/>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF51285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC70518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
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    </evidence>
    <sequence length="342" mass="38858" checksum="F6711D4A5DB96B16" modified="2016-11-02" version="1">MPITRKRQADLDDGIDLRSSEETNERPKKYQKGVNHRRLALKVPDGTMPFKFPHCTQTLDSEMLYDDPLPEDHKQLFRGNETDQLIHRRLHRLMAKIPRISIFPYVIRDIKKPGKRSKWSRQVNLKSIQEKFAYTSSWVTRWEKGPQQHARLALFISPNKLSELSHAWAAAIVDVKGGGRYLVIYDCDSSVTDRARGEALVFSHLDQSQKDFIASIRASKKKRHGGLDIQTIYYGGIAKHKNPNMCLENTLSWMESCVDIKNLKRDNLTSDFEYKIVSLTPDAPMRARARAIDAVRSEAENAKQGKVDVTGIDAAEEAEGDHSSATKYASSSYFHPSGDDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I739</accession>
    <name>A0A1B9I739_9TREE</name>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
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    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="101"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF51357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC70588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="21452" checksum="0411C55D2B324CDC" modified="2016-11-02" version="1">MAGARQRTNAQRKQRDEDEEPLNTNEILDNDGQEEQIRLLREKNTSDNKQAHLALDFGVLISSIISILQFFDHLSSSNPIFSILSVFQFVLLPFSLTPGWIPFLPTISSENHLYSFSIQLTVSLCALFIRYHHSLPGGSDMISLELGEIARWIIPTLVVGAIDLQRRSEKQSEENLLELEKLKYDLKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I7I0</accession>
    <name>A0A1B9I7I0_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">I206_02143</name>
        <name evidence="3" type="ORF">I206_104609</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Cryptococcaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV700115">
        <property type="protein sequence ID" value="OCF51429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144524">
        <property type="protein sequence ID" value="WWC70658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_019012648.1">
        <property type="nucleotide sequence ID" value="XM_019153908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I7I0"/>
    <dbReference type="GeneID" id="30170512"/>
    <dbReference type="KEGG" id="kpin:30170512"/>
    <dbReference type="OrthoDB" id="10591042at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
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        <location>
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            <end position="195"/>
        </location>
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            <end position="292"/>
        </location>
    </feature>
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        <location>
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            <end position="377"/>
        </location>
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        <location>
            <begin position="139"/>
            <end position="152"/>
        </location>
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        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF51429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC70658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="411" mass="44879" checksum="A1DD10767E2F2EBE" modified="2016-11-02" version="1">MALVSTHAPTSFVPSSMPDTLPYTDTDDDSRHVGEMLNPDGTVTAQGARFFDEQRRRITDRIKSCATDHDSKKFIKYMTEALDRTIEDGMEEETAPGVHQYIRTYLDSWQERAPVAAKKAEDKYNAIMQHREVYRDAHQSVTAQDTAASGSGQLLPASWATNPRPKYQLTQYPSEEESGSDSDYGSGSSGSTAISLCTGEQNTINKVPDTQIVANDPKMHHLRVIGKTAHPSLLPADSQFADSELVSGTHDNAQKPYNQALIKPMNDWLASRHGQPSFTQGNATGGDPVRSISPFVRQYNQSNSTNGRYPTSTFSHGNKINTGTLAKAMSNVESLFESLAASMNPDQSDVVRYKKSNPDGTYQQMGAAQEDGEDGSRTEITFHSGKRGNTQFSSFSSLTTFGGQPLIASAA</sequence>
</entry>
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    <name>A0A1B9I7Q9_9TREE</name>
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        <submittedName>
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        <submittedName>
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        </submittedName>
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        <name evidence="13" type="ORF">I206_02220</name>
        <name evidence="14" type="ORF">I206_104682</name>
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        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the ubiquitin family.</text>
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        <property type="protein sequence ID" value="OCF51506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_019153985.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A1B9I7Q9"/>
    <dbReference type="STRING" id="1296096.A0A1B9I7Q9"/>
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    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="CDD" id="cd01803">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Polyubiquitin Ubiquitin"/>
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        <property type="entry name" value="PRK00432.1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01599">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01402">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="Zn-binding ribosomal proteins"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9 14" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="12">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OCF51506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="WWC70731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="160" mass="18141" checksum="F3B4957987B898DD" modified="2016-11-02" version="1">MQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMAKKRKKKNYTTPKKIKHKRKKVKMAILKYYKVGSDGKIQRLRRECPAPQCGAGVFMAWHKDRQSCGKCGLTYTFEPGTKPTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I8H3</accession>
    <name>A0A1B9I8H3_9TREE</name>
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        <recommendedName>
            <fullName evidence="3">rRNA-processing protein EFG1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">rRNA-processing protein efg1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_02406</name>
        <name evidence="10" type="ORF">I206_104866</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">CBS 10737</strain>
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    <reference evidence="10" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
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        </source>
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                <person name="Heitman J."/>
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                <person name="Young S.K."/>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
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                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
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                <person name="Gargeya S."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019154418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I8U0"/>
    <dbReference type="GeneID" id="30171024"/>
    <dbReference type="KEGG" id="kpin:30171024"/>
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            <dbReference type="EMBL" id="OCF51939.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC71161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="229" mass="24811" checksum="DD5B3D7042D6C050" modified="2016-11-02" version="1">MQLQNASSDGSGYTVQLSENVTWSYPFLPGEPPNVIHRNFSACVPSNITIASKCCSAVNGTFVTQELSNSRKLNQSEINSIFEEKYPEQNITSLVYTQAIIGDLTNTTNVTSNSFDGYPGINWCSFEYNPLSNDPLVGIGYQSGPTTGYKPEAMNNWIQCFNENVPQEAFNNSQAAYVCATADVRDGGILEGFKRYTGSNKGSGSETTTIVGHLWGIIGLLVIGVGMLT</sequence>
</entry>
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    <accession>A0A1B9I8V6</accession>
    <name>A0A1B9I8V6_9TREE</name>
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            <fullName evidence="5">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
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        <name evidence="7" type="ORF">I206_105134</name>
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        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
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    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
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        <property type="protein sequence ID" value="OCF51959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Chromosome 6"/>
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    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
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    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01370"/>
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    </evidence>
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            <dbReference type="EMBL" id="OCF51959.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="WWC71181.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
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    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Abouelleil A."/>
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                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Saif S."/>
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    <reference evidence="3" key="2">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
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                <person name="Imamovic A."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
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                <person name="Gargeya S."/>
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                <person name="Griggs A."/>
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                <person name="Imamovic A."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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    <reference evidence="5" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
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                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
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        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
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                <person name="David-Palma M."/>
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                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <dbReference type="PANTHER" id="PTHR12387">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSN8/PSMD8/EIF3K" evidence="3">
        <location>
            <begin position="103"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OCF52245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="WWC69524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="298" mass="33119" checksum="F29F24376DC1D889" modified="2016-11-02" version="1">MSVDLQQSLSELQQAFDAPEGSRDDVSKRLAKLKLELAQSGLYFAPPTANSQDLVAARSILEIGTFHSLRQGNLKSYAQYNFALQPFYDNLSSIIPDSPNRPITLGLHLLALLSEGLLSQFHTVLETLKIEQLSDVFVKLPVDLERWLMEGAYNKVYRAKDRVPREEFGFLLERLMGTVRVQIATTIETSYKSLPLKSALSLLFFNSNEISKLNEFTSAREWELSPSSQIFTFPNSTKPDIALAAQQQQNGINANGEQSETSNPTLDLLKGKGVSRGTPMQTMVGPALRLAQQLEAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9I9N5</accession>
    <name>A0A1B9I9N5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_01562</name>
        <name evidence="6" type="ORF">I206_103435</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI894008">
        <property type="protein sequence ID" value="OCF52275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144522">
        <property type="protein sequence ID" value="WWC69494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013494.1">
        <property type="nucleotide sequence ID" value="XM_019153333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9I9N5"/>
    <dbReference type="STRING" id="1296096.A0A1B9I9N5"/>
    <dbReference type="GeneID" id="30169931"/>
    <dbReference type="KEGG" id="kpin:30169931"/>
    <dbReference type="OrthoDB" id="2564331at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="4">
        <location>
            <begin position="567"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="52"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="353"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="439"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="369"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="449"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF52275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC69494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="671" mass="75970" checksum="5C3594EE344A40A3" modified="2016-11-02" version="1">MPAVAAFSAPMGPWNQAISSMQIRNTPVLPNDMYWSSSPACEQNHPDYSNTYPCTTPSSTTSQKSKYEIGSTHPATLSTAPTGYGYRIIDRPKPKSSRSSSSLQSDDQKITHILGNITNLLLQQSQLINTNQEKLIITENEVQANFNELNEKVRSLTQDQLNSFTDLRNYLKEKVDQSTKRLDYMCKSGNLKRRIGNKNNGPTGKSKGKSNLMSSFRNDIDTTPSSEAIVEDLIRFDTPCPELEVQNFVNQFMDVTPQPVMDLDNFTNDAHHFARNPLPSLPEENMACSLDQTLVDKAVSRQLALLNGKHVLPEGEDAVGFIFRKRLKGNRCDNGFKIDMSFLDEISIAAHAHSGGDSSNLSSGVDSLPNTGNTNTPVPNTQHTYQTANIAKPWNPFPLNYIREPTALSIADHSSVVSTDDSILTSVKRGTSLVEDKLLLPGSPEPPVPRKRRRSGRVHASHKRKGKANVWPNYGINTVKTRMEEIICDTCGGRVHWACAGLNHGKSMREAPWSCPDCLTILMEAEEDEDGRLPSIPRAQQEKCLRPDCIFLTAKKIVRKNDDDNEFYLEKIIGRKRLHYNDNGGATYIYLIKWYDWEIYDSTWEPAKNIPDLERWETIFLQQFKHSPDVLTQRVWLLEECTPWFDYKGHYNTELLKSLNIEKRTWWDDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IBF2</accession>
    <name>A0A1B9IBF2_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_00037</name>
        <name evidence="8" type="ORF">I206_101286</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF52741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC67378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019013960.1">
        <property type="nucleotide sequence ID" value="XM_019151822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IBF2"/>
    <dbReference type="STRING" id="1296096.A0A1B9IBF2"/>
    <dbReference type="GeneID" id="30168406"/>
    <dbReference type="KEGG" id="kpin:30168406"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
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</entry>
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
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                <person name="Nusbaum C."/>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
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                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
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        </source>
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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                <person name="Litvintseva A."/>
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                <person name="Heitman J."/>
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                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
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                <person name="Imamovic A."/>
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                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5008628590" evidence="1">
        <location>
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            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OCF53050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="WWC67068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="247" mass="27957" checksum="9B5BB373EE2E2DBA" modified="2016-11-02" version="1">MVLGILSAVAACPAIIGTTEAVRHGQKAQAKEAHRGQKVNMIVKLPTAVPGYTEKFDGALIVLKDNKLYIRHSQSTFPPDSIHPFAGYYLPYPSNQTKWAGAGYKGEGLVSTINEANQLNWIYVDRNTHELKYGIKTDVENHCAGPWDCTSIEKRMTFESWEGFIAVQEDSNKDIWSLYFDRFDDGLSSNGLIGDGRQIRMLEIQLIRKERVKGFDMACEERVERIRAMRGKQKEQQEEGLQGEQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
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    <name>A0A1B9ICI0_9TREE</name>
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        <submittedName>
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        <name evidence="5" type="ORF">I206_00527</name>
        <name evidence="6" type="ORF">I206_100800</name>
    </gene>
    <organism evidence="5">
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        <lineage>
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    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Interacts with the elongator complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the KTI12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC66893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_019152307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9ICI0"/>
    <dbReference type="STRING" id="1296096.A0A1B9ICI0"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00025768"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00063730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF53226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC66893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="300" mass="33662" checksum="58DCB9FC2F5BED86" modified="2016-11-02" version="1">MALVTIAGFPCSGKTTRAKQLKEYFEQRIRSTEYNGPNLNVELIDDDISHVPRSSYDTSALEKPARASLFSNVSRSLGQDTITIVDSANYIKGYRYQMYCAAREARVRVATIHVVASPDKCAEWHEKRGECSYKPATFDNLIMRFEEPSSMVRWDSPLFTIPWDEEPPFEEIWNAILKGDKKPPPAAVLQRNKPPPNTLQTLTKTTQLIVTSLLSHISSLPGTTTFPIPSPPSPSSNSLILHLPPGRKLTLSEMQRLKRQYESVMQKGQQSGGIAASGNWSEEEVATGFVRFLEQLWETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9ICV5</accession>
    <name>A0A1B9ICV5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RanBP2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_00668</name>
        <name evidence="8" type="ORF">I206_100657</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC66752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014585.1">
        <property type="nucleotide sequence ID" value="XM_019152447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9ICV5"/>
    <dbReference type="STRING" id="1296096.A0A1B9ICV5"/>
    <dbReference type="GeneID" id="30169037"/>
    <dbReference type="KEGG" id="kpin:30169037"/>
    <dbReference type="OrthoDB" id="2565234at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23111:SF40">
        <property type="entry name" value="RNA-BINDING PROTEIN INVOLVED IN HETEROCHROMATIN ASSEMBLY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23111">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="434"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="32"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="83"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="505"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="505"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCF53366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC66752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="581" mass="64627" checksum="A4D8AEB5485C5D6D" modified="2016-11-02" version="1">MIEEPLFSVSGNRQSRTAEEIQSLLRSLSVRSPKNENQIQAPVTPSRGNISASHTSKSENSIDSTAYINTMGSQNHFTRPLIQRNGHQTSPSTSSNRSQGEDINKKPLPIGTEKKLGLLDKAPSRSPPQLYDGYPSRYNVQFTMWHESPAPRYTEDHLTSPVDARMTDRARQICQENRLEAQMQQTRDRQVWEHSLEPRQTESEFINHSLRQATQAVATPRTATFDPFGQEGNTTTAQNASLSSNFEDDQFSEFVNTPGFGGFAITYGTSSYQPNYRSGQPISSPTGIDHVNGIRRHTTQAAEHSKGQALVIFDREPSNLPAATSLRDSEQLRYSDYEFLENQRENRIDHPRVSHSRVVSLEGIHIDENSSQHVASTQSSPNHHYTLAEADRYEISSIPRRAGWSTAQQSHIGLLPANWGPGLEAVPPAAPPFAPGDWYCRQPYCGYHNFSKNIDCRACGHPRPPEPIATSSSVTSPPLGSVGDWRCECGYINWRRRALCKQCHPDHPSNREPERKDSNAGQQRNRHLGSTSVSAVGNTFANTHQGINAAYITTAQSGIAGIIGHGTYRENLGHTAWSPHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IDD6</accession>
    <name>A0A1B9IDD6_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Tubulin gamma chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">I206_00632</name>
        <name evidence="13" type="ORF">I206_100693</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">CBS 10737</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Spindle pole body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the tubulin family.</text>
    </comment>
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        <property type="protein sequence ID" value="OCF53330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014549.1">
        <property type="nucleotide sequence ID" value="XM_019152411.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A1B9IDD6"/>
    <dbReference type="STRING" id="1296096.A0A1B9IDD6"/>
    <dbReference type="GeneID" id="30169001"/>
    <dbReference type="KEGG" id="kpin:30169001"/>
    <dbReference type="OrthoDB" id="10249382at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
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    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="C:spindle pole body"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
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    </dbReference>
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        <property type="term" value="P:microtubule nucleation"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02188">
        <property type="entry name" value="gamma_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000004">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002454">
        <property type="entry name" value="Gamma_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
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    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01164">
        <property type="entry name" value="GAMMATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
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        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
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            <end position="246"/>
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    </feature>
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            <end position="395"/>
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</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IDL3</accession>
    <name>A0A1B9IDL3_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein mL46 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">I206_00981</name>
        <name evidence="4" type="ORF">I206_100344</name>
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    <organism evidence="3">
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">CBS 10737</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="WWC66442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014894.1">
        <property type="nucleotide sequence ID" value="XM_019152756.1"/>
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    <dbReference type="KEGG" id="kpin:30169350"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_mL46"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_mL46_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L46, MITOCHONDRIAL PRECURSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11788">
        <property type="entry name" value="MRP-L46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Large ribosomal subunit protein mL46 N-terminal" evidence="2">
        <location>
            <begin position="45"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OCF53675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="WWC66442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="290" mass="33109" checksum="BF28B9254B567844" modified="2016-11-02" version="1">MSFSPKSLIRPTSSLRRSALQRFSSSSTSSSSSTSSSSSTSQPPLIASLILSRNPLLTKTPNELESTYYSYSRSIKHSLSTPLPLDFYFKSGSLPLRRFLKKEKEFEKEIYNERLISNTNNNEGLDDIPPETEYEILERDHFLKQDKEKNGKIENSLERFPEQEIFCLIQDKKNKKWNFPNTKVEKLESLDEAINSKIIGVDGQLDGKGLDSWLVTKKPIGVYKDGEQRTFFLRGHILSGQPTLSPSSDYSSHAWLNVEEIEERLRKQGDEKLWEGIKGMFGIGEEVEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IDL8</accession>
    <name>A0A1B9IDL8_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">I206_00892</name>
        <name evidence="8" type="ORF">I206_100435</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014806.1">
        <property type="nucleotide sequence ID" value="XM_019152668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IDL8"/>
    <dbReference type="STRING" id="1296096.A0A1B9IDL8"/>
    <dbReference type="GeneID" id="30169261"/>
    <dbReference type="KEGG" id="kpin:30169261"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000245">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="site" description="Deprotonates C-terminal active site Cys" evidence="4">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="4">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="4">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="5">
        <location>
            <begin position="30"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OCF53587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="WWC66532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="104" mass="11334" checksum="A3C7059F2DDBEFE3" modified="2016-11-02" version="1">MVKAIESKSEFDSLIAGSEPVVVDYWATWCGPCKMISPHFAKLEAEYPGVKFVKVDVEEQEEIALFAGIKAMPTFIAYKDGQPIETVTGAVPAKLNALLEKISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1B9IDZ3</accession>
    <name>A0A1B9IDZ3_9TREE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">I206_01079</name>
        <name evidence="6" type="ORF">I206_100246</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Cryptococcus pinus CBS10737.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2016-07" db="EMBL/GenBank/DDBJ databases">
            <title>Evolution of pathogenesis and genome organization in the Tremellales.</title>
            <authorList>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Heitman J."/>
                <person name="Chen Y."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S."/>
                <person name="Zeng Q."/>
                <person name="Chapman S."/>
                <person name="Gujja S."/>
                <person name="Saif S."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">CBS 10737</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HpcH/HpaI aldolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI894007">
        <property type="protein sequence ID" value="OCF53772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014991.1">
        <property type="nucleotide sequence ID" value="XM_019152853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1B9IDZ3"/>
    <dbReference type="STRING" id="1296096.A0A1B9IDZ3"/>
    <dbReference type="GeneID" id="30169448"/>
    <dbReference type="KEGG" id="kpin:30169448"/>
    <dbReference type="OrthoDB" id="1621678at2759"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000029">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.2, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050251">
        <property type="entry name" value="HpcH-HpaI_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502">
        <property type="entry name" value="2-KETO-3-DEOXY-L-RHAMNONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="4">
        <location>
            <begin position="32"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OCF53772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="WWC66345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="263" mass="28377" checksum="4711F921DBF6D8B6" modified="2016-11-02" version="1">MESRTYLKNDLQAQKKGLGFWCTLPGACTVSTVLATGGFNWVLIDAEHGAITDKDYFDLCLAITHGGASPIIRVPWNEEWMIKRALDSGAQGVMTPMCHNAEDAKKIVSFSKYPPIGSRGYGPMFCPPVFGCKGSEYDSSADEKLLVIVQIESRQGIENVEEIAKVPGLDVLFIGPFDLSKQLNVKFGGDEHEAAIAKTLKAAHAAGKTAAIFCPNGQVAKQRLDQGFDMVSIAVDNACLAAEMERQMGFATGTTKSGDRSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8KXF7</accession>
    <name>A0AAJ8KXF7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">I206_100125</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_070058239.1">
        <property type="nucleotide sequence ID" value="XM_070202138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8KXF7"/>
    <dbReference type="GeneID" id="30169571"/>
    <dbReference type="KEGG" id="kpin:30169571"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="15"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="926"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="929"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="WWC66224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094020"/>
        </source>
    </evidence>
    <sequence length="1106" mass="123130" checksum="C5996EA54CEE4F39" modified="2024-07-24" version="1">MMSEEPKKKRRQNVACSCCKLRRIKCDLQEILTALPSSSSSSPPPLNVLVEQNPDIECSNCIKKGLKCDTQGIREPTKPNKGGKRIDEARKVYGGQDPRGSSYRVDDNPLELFSNIPSCPPESLPLTSSHAFPDATAPLFDASGLLNLPAPPEDMVNNDPPTSNVPALTSGETLGTFQEAASIWRQFADHRQEAINHVQTTGQTPRAHLAQLPESDHIWDQNLQNRVSSELAQMQRLAEASDKGFSSASQSTIDLPDPFNARSNLPILQSSIPSPIPSPYSFDHISNNQLTPLSGYNDYITNGYSRKRSRSPYEEEQFDSHKLLAQNPWRLWSENQNHREMVNWGRREAVSEQLADRALGMALSNHLVKTFFQAVHLSFPAISPEAFYLEWAKAGQRSDRMTPAQEALCAVIEAWGARYSDSPVILGVSANSALAPKVIKPDGTFAPGTRARAHWGRARITACKGLMKRAKRLIDENGLFTNPSITGVQALTLYNQAMHMTDQQVIEKDHWLQRPIITDDNEADISFSQLQMKQRRLFWTHMVSDAFFAASIGQLPKIPQEDVDSAGEWIETVQERLPNSSFKLLAFFLQMNHRLGLAGREVATRIAYPSRRKGAADVEKLCSASRKIWRDLKSISKDLNTKVTLYLESCRKDDLLGFSPLNFHANLRLCCPFLLLVMHQLIRDLLDFWKTMPVATASIATPSDNTSYSSPSSASSGQQRPFVPGMRNIELLERLSRESIDGLLANCRSQIGMLQSILPTGVIQCRSLCYFHQLTYVAGSILLRVLMSMAQLLSEVPTNEQGYPSNTPGGYGWTWETKQQSVNICLEALHQIGWAWADVGPICDSVGLTMERMTPSPDELLAWQTNNLPTPPSADIIRAKEEEQKASEEAVKSVLVFWPTASVPQLIENAMQKDPKAILHGLMDMGRQTPPNSQYQSSQSFKPPATSLSEHDPLRPIPTQVHNDPTRSIIGNLVGAVGDKIMGDHGQSIIDSSYQLPENQRPTVSDPFEMSGFASTTQTQNIPEPQYDDSTNLANLQTFLNQKSDRFMEFYQFPANDPHVSLEMDSNALPVAPEQTFDQLDVEAFLNELGLPQEPIVPVDPPGERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8KZM7</accession>
    <name>A0AAJ8KZM7_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">I206_100377</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
            <authorList>
                <person name="Coelho M.A."/>
                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">CBS 10737</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP144519">
        <property type="protein sequence ID" value="WWC66475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_019014861.2">
        <property type="nucleotide sequence ID" value="XM_019152723.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0AAJ8KZM7"/>
    <dbReference type="GeneID" id="30169317"/>
    <dbReference type="KEGG" id="kpin:30169317"/>
    <dbReference type="Proteomes" id="UP000094020">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000060">
        <property type="entry name" value="Aspartic-type endopeptidase ctsD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000008">
        <property type="entry name" value="Cathepsin D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF75">
        <property type="entry name" value="ENDOPEPTIDASE (CTSD), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07040)-RELATED"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
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            <begin position="18"/>
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    <sequence length="586" mass="63179" checksum="4BE14C7BD32AF9AD" modified="2024-07-24" version="1">MIPLITLFFLFPLFVISRPLQSNPLHRLTLRKIPIARNDEHPISTFERHHEAAIQRMHRYKRQLPPSEKAFQEIKLERRKFIESNLKLDKRLYIPDVLPPDLPRDEDKRAYWRSNHTITSPSTYRGAKPNLALEGHITIEGVAAAETTVRASGSNDNGFSEIAIQALQEGTLTNSDSDLIQGGLDYIIEANDIGYLCEIQIGTPAQTFLMLMDTGSADTWVPSTTCGLQACGDHTALGADNSQTFQASEQQFQVTYGSGAVAGVLATDTITIAGMTLENHALGVALQESIQFSGNDVPFDGLVGLALGKLSNQGVSTPIESLASTGLIKSPILGIALGRFTDGENNGELVFGQADTSKFDASTTQSLRVTSDDGFWQIDMAAVNVDGVEVVQGRQAILDTGTSLIIAPPADAAAFHAQIDGAIDVGGGMFSIPCTINQEITMTFGKIAFQIDVRDLLFQPLSNDLKGNCLSSISSGLIKDDLTWLLGDSFLKNVYMITNSNDLTIQLSSKTDIKGIPPPPTSLTTTVQMGLSTNTSNDNSTDSTINTTANQSNFSSSTVNRTTYLNSATFSIISALAALLAGEKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8KZU9</accession>
    <name>A0AAJ8KZU9_9TREE</name>
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        <recommendedName>
            <fullName evidence="11">Guanyl nucleotide exchange factor Sql2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">I206_100430</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C."/>
                <person name="Imamovic A."/>
                <person name="Larimer J."/>
                <person name="McCowan C."/>
                <person name="Murphy C."/>
                <person name="Pearson M."/>
                <person name="Priest M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Sykes S."/>
                <person name="Wortman J."/>
                <person name="Nusbaum C."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2024-02" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis evolution and contrasting modes of karyotype evolution via chromosome fusion or intercentromeric recombination.</title>
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                <person name="David-Palma M."/>
                <person name="Shea T."/>
                <person name="Bowers K."/>
                <person name="McGinley-Smith S."/>
                <person name="Mohammad A.W."/>
                <person name="Gnirke A."/>
                <person name="Yurkov A.M."/>
                <person name="Nowrousian M."/>
                <person name="Sun S."/>
                <person name="Cuomo C.A."/>
                <person name="Heitman J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">CBS 10737</strain>
        </source>
    </reference>
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            <begin position="41"/>
            <end position="125"/>
        </location>
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            <begin position="961"/>
            <end position="1094"/>
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            <begin position="1167"/>
            <end position="1401"/>
        </location>
    </feature>
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        </location>
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            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1421" mass="156429" checksum="E464AA8FA7CC9E93" modified="2024-07-24" version="1">MISHKSKASSSSYHSISSEAGPSTHYVRSPPTPISPHHAPRLPTHVQAIHDFDPSLLASTSASNSNMYLNFKSGEIIRVHVRDATGWWDGEISGTARLVHETEEHTVKGVRRGWFPSNYVREMGWDGSFHRRDESSSTNQTSTTSPTTQRSETYHTRHASAASHQSRASTSTTSQHRTSPLDQQDPKNLDPVFQTLMHPIVQSLSLLESAIHSNRKPHIQPSTACVISSIRAALMQTDCLSKESTTLITWPVLARERKIVLVELSKLVGCAKTAGSVEEVEDVDDTKELEALARAARGVFASVKRFLHLADECGVTVTLMDAAQEEANGISINADKAAGRPASTSSDGADQSTIGRSRVNTTSSSNPRLQETFRLRTASINDLRAARRRAASPPPPLPTASVVSSASSSRNGRERSPSIMHTPMSAKFPQGTSVASPISTKSVHERRLPGSVDSAFSQVSVASSEDAHMPWGDTTPVPTPQATETNRQLGSVADVYEAIGHAEDALLSLIAAFIGHIHSHSINSHPSSHAHLIEMTRETIDSVRELLTIVEAVGRSAGVRHKRPREIDTLRIAKDQLYDVASKLVESAEIVANAPFSDSGEDRYDTEKGRLLQAATSTLRAGTECVRLVKMCLPEDNAVHLHATPRQADANSRQSTPRPGHTHEAPLIMREKPVGARGVHTLSGLHRKATSLSTLQKRYQQDGAMVQAPLEEDENEETEEEEDQEVVQDLNKDEDMTMRPMMQSILGTPVRFPMRPTLQHNHTSPMPLSSANRPSEELLKALDDSNTTGTRNRSSSLTSPAPPRMKHRSPSRSADLDKFTADYDIRLEPPKRASRGTISASSRLSTYTSASSQISGTSTAPTSIRSSNVSEFNNLLPQTPPVHDIPAFCDLKVDIPSATPDLSQSATYLSLNDQPPPKPLALLRPAAPVRSITAPAPSANSDVRFWVVAHDYDPREIAFNSEGAIIGASLAVLVEKMTPHDGPVDPTFNATFFYTFRLFTTPTQLLEAVMTRYDLQPPAAMAFGEKERALWIERKVVPVRLRIYNFLKSWLDQHWREETDDVVLDTLHDFARDVVSVTLPAMGPRLADAVRRRLNGPMSAVSDRSSIKSINRPVSMDRIRSASQSGFLHPPTISGGLPPTPVISKNLHSVLHKAASSGNNVNITEFDTLELARQFTIMESKMFCSVIPEDLLQTGKKTIPELKALSTLSNQITGWVADSILNETDAKKRASLVKFFIKLADKCLIMYNFSTMFAVLAGLNSSTIMRLKKTWDALPTKYKVTIERLRGVIEHTKNHAAYRAKLREAPTPCLPFLGLILTDITFTSDGNPSTRPSVLEPEIVLINQDKYNKLGRIAMDFKRYQEPFNFHELEAVQTFLKRVLTERGSGSVDALYRKSLMLEPRQGAEKFSANVERPNWLIGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2024-07-24" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0AAJ8L0Q5</accession>
    <name>A0AAJ8L0Q5_9TREE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED17</name>
        <name evidence="10" type="ORF">I206_101179</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Kwoniella pini CBS 10737</name>
        <dbReference type="NCBI Taxonomy" id="1296096"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Tremellomycetes</taxon>
            <taxon>Tremellales</taxon>
            <taxon>Cryptococcaceae</taxon>
            <taxon>Kwoniella</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Cuomo C."/>
                <person name="Litvintseva A."/>
                <person name="Chen Y."/>
                <person name="Heitman J."/>
                <person name="Sun S."/>
                <person name="Springer D."/>
                <person name="Dromer F."/>
                <person name="Young S.K."/>
                <person name="Zeng Q."/>
                <person name="Gargeya S."/>
                <person name="Fitzgerald M."/>
                <person name="Abouelleil A."/>
                <person name="Alvarado L."/>
                <person name="Berlin A.M."/>
                <person name="Chapman S.B."/>
                <person name="Dewar J."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Hansen M."/>
                <person name="Howarth C
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